keyword
https://read.qxmd.com/read/38166508/flow-flow-dysfunction-of-hemodialysis-vascular-access-a-randomized-controlled-trial-on-the-effectiveness-of-surveillance-of-arteriovenous-fistulas-and-grafts
#21
JOURNAL ARTICLE
Bianca Zomer, Matthijs S Ruiter, Friedo W Dekker, Ellen Gd Goertz, Michiel W de Haan, Marc Hh Hemmelder, Mickaël Jc Hiligsmann, Wanda S Konijn, Magda M van Loon, José Mc Maessen, Barend Me Mees, Joris I Rotmans, Geert Wh Schurink, Marie-José Jpj Vleugels, Maarten Gj Snoeijs
INTRODUCTION: It is assumed that identification and correction of asymptomatic stenoses in the vascular access circuit will prevent thrombosis that would require urgent intervention to continue hemodialysis treatment. However, the evidence base for this assumption is limited. Recent international clinical practice guidelines reach different conclusions on the use of surveillance for vascular access flow dysfunction and recommend further research to inform clinical practice. METHODS: The FLOW trial is a double-blind, multicenter, randomized controlled trial with a 1:1 individual participant treatment allocation ratio over two study arms...
January 2, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38160799/ultrastructural-examination-of-glomerular-fibrillary-deposits-in-diabetic-nephropathy
#22
JOURNAL ARTICLE
Sophie I Nagelkerken, Peter H Neeskens, Joris I Rotmans, Volker Nickeleit, Jan A Bruijn, Ingeborg M Bajema
Glomerular fibrillary deposits have occasionally been reported in diabetic nephropathy, but no large-scale, ultrastructural evaluation of these deposits have been reported so far. Here, we report our study of glomerular non-Congophilic, DNAJB9 negative fibrillary deposits in diabetic nephropathy as characterized by transmission electron microscopy. Clinical data from 55 patients with biopsy-confirmed diabetic nephropathy and 18 healthy living donors were reviewed, and their biopsies evaluated by light microscopy, immunofluorescence, and electron microscopy...
December 29, 2023: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://read.qxmd.com/read/38082484/prognostic-models-in-nephrology-where-do-we-stand-and-where-do-we-go-from-here-mapping-out-the-evidence-in-a-scoping-review
#23
JOURNAL ARTICLE
Jet Milders, Chava L Ramspek, Roemer J Janse, Willem Jan W Bos, Joris I Rotmans, Friedo W Dekker, Merel van Diepen
Prognostic models can strongly support individualized care provision and well-informed shared decision making. There has been an upsurge of prognostic research in the field of nephrology, but the uptake of prognostic models in clinical practice remains limited. Therefore, we map out the research field of prognostic models for kidney patients and provide directions on how to proceed from here. We performed a scoping review of studies developing, validating, or updating a prognostic model for patients with CKD...
December 12, 2023: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38051068/impact-of-multiple-sclerosis-subtypes-on-pain-management-in-patients-with-trigeminal-neuralgia-after-stereotactic-radiosurgery-an-international-multicenter-analysis
#24
JOURNAL ARTICLE
Fernando De Nigris Vasconcellos, Elad Mashiach, Juan Diego Alzate, Kenneth Bernstein, Lauren Rotman, Sarah Levy, Tanxia Qu, Rodney E Wegner, Matthew J Shepard, Samir Patel, Ronald E Warnick, Nuria Martínez Moreno, Roberto Martínez Álvarez, Piero Picozzi, Andrea Franzini, Selçuk Peker, Yavuz Samanci, Ahmed N Elguindy, Joshua D Palmer, L Dade Lunsford, Shalini G Jose, Zhishuo Wei, Ajay Niranjan, Sarra Blagui, Christian Iorio-Morin, David Mathieu, Robert G Briggs, Cheng Yu, Gabriel Zada, Samantha Dayawansa, Jason Sheehan, Michael Schulder, Anuj Goenka, Sabrina Begley, Hamza Khilji, Dušan Urgošík, Roman Liščák, Douglas Kondziolka
BACKGROUND AND OBJECTIVES: Trigeminal neuralgia affects approximately 2% of patients with multiple sclerosis (MS) and often shows higher rates of pain recurrence after treatment. Previous studies on the effectiveness of stereotactic radiosurgery (SRS) for trigeminal neuralgia did not consider the different MS subtypes, including remitting relapsing (RRMS), primary progressive (PPMS), and secondary progressive (SPMS). Our objective was to investigate how MS subtypes are related to pain control (PC) rates after SRS...
December 5, 2023: Neurosurgery
https://read.qxmd.com/read/37988447/prevalence-of-pericardial-late-gadolinium-enhancement-in-patients-after-cardiac-surgery-clinical-and-histological-correlations
#25
JOURNAL ARTICLE
Anna Giulia Pavon, Ruben Martinez Fernandez, Dimitri Arangalage, Luca Bergamaschi, Niccolò Maurizi, Sebastien Colombier, Samuel Rotman, Anna Nowacka, Judith Bouchardy, Juerg Schwitter, Matthias Kirsch, Pierre Monney, Tobias Rutz
BACKGROUND: Pericardial late gadolinium enhancement (LGE) is usually associated with active pericarditis, but it is not infrequently found in patients after cardiac surgery even a long time after the intervention. The clinical relevance of this finding and its histological correlates are unknown. We sought to determine the prevalence of chronic pericardial LGE in patients after cardiac surgery. METHODS: All consecutive patients with previous cardiac surgery, who were referred to cardiovascular magnetic resonance between January 2017 and December 2021 were enrolled in the study...
November 2023: Circulation. Cardiovascular Imaging
https://read.qxmd.com/read/37965964/revised-model-for-the-type-a-glycan-biosynthetic-pathway-in-clostridioides-difficile-strain-630%C3%AE-erm-based-on-quantitative-proteomics-of-cd0241-cd0244-mutant-strains
#26
JOURNAL ARTICLE
Bart Claushuis, Arnoud H de Ru, Sarah A Rotman, Peter A van Veelen, Lisa F Dawson, Brendan W Wren, Jeroen Corver, Wiep Klaas Smits, Paul J Hensbergen
The bacterial flagellum is involved in a variety of processes including motility, adherence, and immunomodulation. In the Clostridioides difficile strain 630Δ erm , the main filamentous component, FliC, is post-translationally modified with an O -linked Type A glycan structure. This modification is essential for flagellar function, since motility is seriously impaired in gene mutants with improper biosynthesis of the Type A glycan. The cd0240 - cd0244 gene cluster encodes the Type A biosynthetic proteins, but the role of each gene, and the corresponding enzymatic activity, have not been fully elucidated...
November 15, 2023: ACS Infectious Diseases
https://read.qxmd.com/read/37951351/optimizing-care-for-autistic-patients-in-healthcare-settings-a-scoping-review-and-call-to-action
#27
REVIEW
Holly K Harris, Laura Weissman, Eron Y Friedlaender, Ann M Neumeyer, Alexander J Friedman, Sarah J Spence, Chloe Rotman, Shari Krauss, Sarabeth Broder-Fingert, Carol Weitzman
BACKGROUND: Within healthcare settings, morbidity and mortality for autistic individuals is high, with unmet health needs despite greater healthcare utilization. OBJECTIVE: We conducted a scoping review of interventions designed to improve the healthcare experiences of autistic individuals and assessed the methodology and outcomes used to evaluate them. DATA SOURCES: Literature from January 2005 to August 2023 was searched using PubMed, EMBASE, CINAHL, PsycINFO as well as hand searching...
November 9, 2023: Academic Pediatrics
https://read.qxmd.com/read/37936395/outcomes-of-early-cannulation-arteriovenous-graft-versus-ptfe-arteriovenous-graft-in-hemodialysis-patients-a-meta-analysis-and-systematic-review
#28
REVIEW
Zhuotao Xiao, Joris I Rotmans, Krzysztof Letachowicz, Marco Franchin, Mario D'Oria
Arteriovenous graft (AVG) is an alternative for hemodialysis (HD) patients with end-stage renal disease when their permanent vascular accesses fail. Since the last decades, the most widely used materials in these patients have been polytetrafluoroethylene (PTFE)-AVGs. Recently, several studies have reported that early cannulation (EC)-AVG can be an alternative to PTFE-AVG. This systematic review and meta-analysis aimed to compare the outcomes of EC-AVG and PTFE-AVG in HD patients. We searched the Ovid Embase, Ovid MEDLINE, and Cochrane Central Register of Controlled Trials for the relevant studies published from 01...
November 7, 2023: Journal of Vascular Access
https://read.qxmd.com/read/37813819/chronic-kidney-disease-increases-the-susceptibility-to-negative-effects-of-low-and-high-potassium-intake
#29
JOURNAL ARTICLE
Martin Gritter, Kuang-Yu Wei, Rosa D Wouda, Usha M Musterd-Bhaggoe, Kyra L Dijkstra, Jesper Kers, Christian Ramakers, Liffert Vogt, Martin H de Borst, Alexander H J Danser, Ewout J Hoorn, Joris I Rotmans
BACKGROUND AND HYPOTHESIS: Dietary potassium (K+) has emerged as a modifiable factor for cardiovascular and kidney health in the general population, but its role in people with chronic kidney disease (CKD) is unclear. Here, we hypothesize that CKD increases the susceptibility to negative effects of low and high K+ diets. METHODS: We compared the effects of low, normal, or high KChloride (KCl) diets and a high KCitrate diet for four weeks in male rats with normal kidney function and in male rats with CKD using the 5/6th nephrectomy model (5/6Nx)...
October 9, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/37783309/the-posterolateral-ligament-of-the-elbow-anatomy-and-clinical-relevance
#30
JOURNAL ARTICLE
Dani Rotman, Nawal Bokhari, Andrew Wright, Adam C Watts
INTRODUCTION: The posterolateral capsule was recognized in the past as an important structure for elbow stability but was later disregarded. Two recent biomechanical papers demonstrated its role in preventing posterolateral instability, and thus it should be identified as a distinct ligament: the posterolateral ligament (PLL). This study includes two parts: an anatomic study of the PLL's footprint; and 5 cases of pathological lesions of the PLL. METHODS: Six cadaveric upper limbs were assessed...
September 30, 2023: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/37685905/sodium-butyrate-as-key-regulator-of-mitochondrial-function-and-barrier-integrity-of-human-glomerular-endothelial-cells
#31
JOURNAL ARTICLE
Maria Novella Nicese, Roel Bijkerk, Anton Jan Van Zonneveld, Bernard M Van den Berg, Joris I Rotmans
The gut microbiota has emerged as an important modulator of cardiovascular and renal homeostasis. The composition of gut microbiota in patients suffering from chronic kidney disease (CKD) is altered, where a lower number of bacteria producing short chain fatty acids (SCFAs) is observed. It is known that SCFAs, such as butyrate and acetate, have protective effects against cardiovascular diseases and CKD but their mechanisms of action remain largely unexplored. In the present study, we investigated the effect of butyrate and acetate on glomerular endothelial cells...
August 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37657787/impact-of-covid-19-policies-on-hospitalists-psychological-safety
#32
JOURNAL ARTICLE
Lily Rotman Devaraj, Benjamin Geisler, Cynthia Cooper, Arabella Simpkin Begin
OBJECTIVES: The coronavirus disease 2019 pandemic brought about many changes in work environment and interpersonal interactions to prevent the spread of infection. Policies such as ubiquitous masking, virtual meetings, physician distancing, and decreased communal eating changed the inpatient work environment. This study aims to look at the impact of these changes on hospitalists' psychological safety. METHODS: We surveyed hospitalists on how these changes affected their well-being and feelings of psychological safety...
September 2023: Southern Medical Journal
https://read.qxmd.com/read/37652744/prosthetic-resurfacing-of-engaging-posterior-capitellar-defects-in-recurrent-posterolateral-rotatory-instability-of-the-elbow
#33
JOURNAL ARTICLE
Dani Rotman, Jorge Rojas Lievano, Shawn W O'Driscoll
BACKGROUND: Posterolateral rotatory instability (PLRI) is a common mechanism of recurrent elbow instability. While the essential lesion is a deficiency in the lateral ulnar collateral ligament (LUCL), there are often associated concomitant bony lesions, such as an Osborne-Cotterill lesions (posterior capitellar fractures) and marginal radial head fractures, that compromise stability. Currently, there is no standard treatment for posterior capitellar deficiency associated with recurrent PLRI...
September 2023: Clinics in shoulder and elbow
https://read.qxmd.com/read/37651665/considering-the-closure-of-arteriovenous-fistulas-in-kidney-transplant-recipients
#34
JOURNAL ARTICLE
Zhuotao Xiao, Joris I Rotmans
No abstract text is available yet for this article.
August 1, 2023: Kidney360
https://read.qxmd.com/read/37622286/divergent-pathways-of-liver-fat-accumulation-oxidation-and-secretion-in-lipodystrophy-versus-obesity-associated-nafld
#35
JOURNAL ARTICLE
Rachael J Klein, Gracia M Viana Rodriguez, Yaron Rotman, Rebecca J Brown
BACKGROUND AND AIMS: Fatty liver is common in obesity as well as in partial lipodystrophy (PL) syndromes, characterized by deficient adipose tissue. Insulin resistance is key to fatty liver pathogenesis in both entities. We aimed to compare the contributions of insulin resistance and adipose tissue to hepatic steatosis in PL and non-syndromic, obesity-associated non-alcoholic fatty liver disease (NS-NAFLD). METHODS: In a cross-sectional comparison of people with NS-NAFLD (N = 73) and PL (N = 27), liver fat was measured by FibroScan® controlled attenuation parameter (CAP) and insulin resistance by HOMA-IR, Adipo-IR, and NMR-based LP-IR...
August 25, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37581437/long-term-survival-from-breast-cancer-brain-metastases-in-the-era-of-modern-systemic-therapies
#36
JOURNAL ARTICLE
Elad Mashiach, Juan Diego Alzate, Fernando De Nigris Vasconcellos, Kenneth Bernstein, Bernadine R Donahue, Zane Schnurman, Jason Gurewitz, Lauren E Rotman, Sylvia Adams, Marleen Meyers, Ruth Oratz, Yelena Novik, Maryann J Kwa, Joshua S Silverman, Erik P Sulman, John G Golfinos, Douglas Kondziolka
BACKGROUND AND OBJECTIVES: Median survival for all patients with breast cancer with brain metastases (BCBMs) has increased in the era of targeted therapy (TT) and with improved local control of intracranial tumors using stereotactic radiosurgery (SRS) and surgical resection. However, detailed characterization of the patients with long-term survival in the past 5 years remains sparse. The aim of this article is to characterize patients with BCBM who achieved long-term survival and identify factors associated with the uniquely better outcomes and to find predictors of mortality for patients with BCBM...
August 15, 2023: Neurosurgery
https://read.qxmd.com/read/37514867/fully-metallic-additively-manufactured-monolithic-double-ridged-waveguide-rotman-lens-in-the-k-k-a-band
#37
JOURNAL ARTICLE
Nelson J G Fonseca, Sophie-Abigaël Gomanne, José Rico-Fernández, Petar Jankovic, Jaione Galdeano, Giovanni Toso, Piero Angeletti, Manuel Arrebola, Oscar Quevedo-Teruel
This paper reports on the design and experimental validation of a fully-metallic double-ridged waveguide 10 × 10 Rotman lens additively manufactured as a single part. The wide band operation of this quasi-optical beamformer enables us to cover the uplink and downlink frequencies allocated to satellite communications in the K/Ka-band, from 17.3 GHz to 30 GHz. The feeding port design was adjusted to enable vertical printing, thus minimizing the use of supporting structures. A prototype was manufactured and tested...
July 21, 2023: Sensors
https://read.qxmd.com/read/37454301/ct-and-chest-radiography-in-evaluation-of-mechanical-circulatory-support-devices-for-acute-heart-failure
#38
REVIEW
Abhishek Chaturvedi, Yonatan Rotman, Timothy Hoang, Greg Jew, Aniruddh Mandalapu, Craig Narins
Acute heart failure and cardiogenic shock are a major cause of morbidity and mortality in patients who have had recent cardiac surgery, myocardial infarct or pulmonary hypertension. The use of percutaneous mechanical circulatory support (MCS) devices before organ failure occurs can improve outcomes in these patients. Imaging plays a key role in identifying appropriate positioning of MCS devices for supporting ventricle function. These devices can be used for left ventricle, right ventricle or biventricular support...
July 16, 2023: Insights Into Imaging
https://read.qxmd.com/read/37446003/building-a-scaffold-for-arteriovenous-fistula-maturation-unravelling-the-role-of-the-extracellular-matrix
#39
REVIEW
Suzanne L Laboyrie, Margreet R de Vries, Roel Bijkerk, Joris I Rotmans
Vascular access is the lifeline for patients receiving haemodialysis as kidney replacement therapy. As a surgically created arteriovenous fistula (AVF) provides a high-flow conduit suitable for cannulation, it remains the vascular access of choice. In order to use an AVF successfully, the luminal diameter and the vessel wall of the venous outflow tract have to increase. This process is referred to as AVF maturation. AVF non-maturation is an important limitation of AVFs that contributes to their poor primary patency rates...
June 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37442436/people-with-diabetes-hospitalized-due-to-ketoacidosis-before-and-after-the-initiation-of-sodium-glucose-cotransporter-2-inhibitors
#40
JOURNAL ARTICLE
Pnina Rotman Pikielny, Tzipi Hornik Lurie, Razi Rabia, Orit Twito, Rachel Hava Rosenblum, Liat Barzilay Yoseph
OBJECTIVE: Diabetic ketoacidosis (DKA) is a rare side-effect related to sodium-glucose cotransporter-2 inhibitors (SGLT2I). This study investigated the incidence of people with diabetes hospitalized due to DKA after the implementation of SGLT2I (2015-2019), compared to the pre-SGLT2I era. METHODS: In this retrospective cohort study, medical records of all adult patients hospitalized with a diagnosis of DKA in a tertiary referral center, from 2011-2019 were reviewed...
July 11, 2023: Endocrine Practice
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