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https://www.readbyqxmd.com/read/29337301/hepatic-gi-signaling-regulates-whole-body-glucose-homeostasis
#1
Mario Rossi, Lu Zhu, Sara M McMillin, Sai Prasad Pydi, Shanu Jain, Lei Wang, Yinghong Cui, Regina J Lee, Amanda H Cohen, Hideaki Kaneto, Morris J Birnbaum, Yanling Ma, Yaron Rotman, Jie Liu, Travis J Cyphert, Toren Finkel, Owen P McGuinness, Jürgen Wess
An increase in hepatic glucose production (HGP) is a key feature of type 2 diabetes. Excessive signaling through hepatic Gs-linked glucagon receptors critically contributes to pathologically elevated HGP. Here, we tested the hypothesis that this metabolic impairment can be counteracted by enhancing hepatic Gi signaling. Specifically, we used a chemogenetic approach to selectively activate Gi-type G proteins in mouse hepatocytes in vivo. Unexpectedly, activation of hepatic Gi signaling triggered a pronounced increase in HGP and severely impaired glucose homeostasis...
January 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29301522/the-low-indexes-of-metabolism-intervention-trial-limit-design-and-baseline-data-of-a-randomized-controlled-clinical-trial-to-evaluate-how-alerting-primary-care-teams-to-low-metabolic-values-could-affect-the-health-of-patients-aged-75-or-older
#2
Nir Tsabar, Yan Press, Johanna Rotman, Bracha Klein, Yonatan Grossman, Maya Vainshtein-Tal, Sophia Eilat-Tsanani
BACKGROUND: Too-low body mass index (BMI), HbA1c% or cholesterol levels predicts poor survival. This study investigates whether e-mails about these low values, improve health of people older than 75 years. METHODS: LIMIT - an open label randomized trial - compares usual care to the addition of an e-mail which alerts the family physicians and nurses to low metabolic indexes of a specific patient and advises on nutritional and medical changes. PARTICIPANTS: Clalit Health Services (CHS) patients in the Northern and Southern Districts, aged ≥75 years with any of the following inclusion criteria: a...
January 5, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29238566/water-level-affects-availability-of-optimal-feeding-habitats-for-threatened-migratory-waterbirds
#3
Yaara Aharon-Rotman, John McEvoy, Zheng Zhaoju, Hui Yu, Xin Wang, Yali Si, Zhenggang Xu, Zeng Yuan, Wooseog Jeong, Lei Cao, Anthony D Fox
Extensive ephemeral wetlands at Poyang Lake, created by dramatic seasonal changes in water level, constitute the main wintering site for migratory Anatidae in China. Reductions in wetland area during the last 15 years have led to proposals to build a Poyang Dam to retain high winter water levels within the lake. Changing the natural hydrological system will affect waterbirds dependent on water level changes for food availability and accessibility. We tracked two goose species with different feeding behaviors (greater white-fronted geese Anser albifrons [grazing species] and swan geese Anser cygnoides [tuber-feeding species]) during two winters with contrasting water levels (continuous recession in 2015; sustained high water in 2016, similar to those predicted post-Poyang Dam), investigating the effects of water level change on their habitat selection based on vegetation and elevation...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29204528/serum-testosterone-changes-in-patients-treated-with-radiation-therapy-alone-for-prostate-cancer-on-nrg-oncology-rtog-9408
#4
R Charles Nichols, Chen Hu, Jean-Paul Bahary, Kenneth L Zeitzer, Luis Souhami, Mark H Leibenhaut, Marvin Rotman, Elizabeth M Gore, Alexander G Balogh, David McGowan, Jeff Michalski, Adam Raben, Shari Rudoler, Christopher U Jones, Howard Sandler
Objectives: We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408. Methods and materials: Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 months after RT. The Wilcoxon signed rank test was used to compare pre- and post-treatment ST levels in patients who were randomized to the RT-alone arm...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29188313/arteriovenous-fistula-maturation-failure-in-a-large-cohort-of-hemodialysis-patients-in-the-netherlands
#5
Bram M Voorzaat, Koen E A van der Bogt, Cynthia J Janmaat, Jan van Schaik, Friedo W Dekker, Joris I Rotmans
OBJECTIVES: Radiocephalic arteriovenous fistulas (RCAVF) are the preferred vascular access (VA) for hemodialysis (HD). Cohort studies from North America revealed that nonmaturation is a significant disadvantage of RCAVFs compared to other VAs. DESIGN: This present retrospective study describes the incidence of nonmaturation of AVFs and functional failure of arteriovenous grafts (AVG) in a multicentre cohort in the Netherlands and attempts to create a prediction model for nonmaturation of RCAVFs...
November 29, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29164753/prevalence-of-left-ventricular-systolic-dysfunction-in-pre-dialysis-and-dialysis-patients-with-preserved-left-ventricular-ejection-fraction
#6
Liselotte C R Hensen, Kathleen Goossens, Victoria Delgado, Rachid Abou, Joris I Rotmans, J Wouter Jukema, Jeroen J Bax
AIMS: Patients with chronic kidney disease (CKD) have an excess of cardiovascular morbidity and mortality, with heart failure (HF) being particularly frequent. Reduced left ventricular ejection fraction (LVEF) defines left ventricular (LV) systolic dysfunction and is associated with poor prognosis. However, CKD patients may have HF symptoms with preserved LVEF. In this subgroup of patients, two-dimensional speckle tracking echocardiography can detect LV systolic dysfunction by analysing LV myocardial deformation...
November 21, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29148008/supervised-preoperative-forearm-exercise-to-increase-blood-vessel-diameter-in-patients-requiring-an-arteriovenous-access-for-hemodialysis-rationale-and-design-of-the-pinch-trial
#7
Esther D Wilschut, Joris I Rotmans, Ernst Jan Bos, Daniëlle van Zoest, Daniël Eefting, Jaap F Hamming, Koen E A van der Bogt
BACKGROUND: Failure of maturation occurs in 30%-60% of arteriovenous fistula (AVF) creation for hemodialysis, with highest rates in distal radiocephalic fistulas. This is partly due to initial small blood vessel size with limited blood flow capacity. Forearm exercise has shown potential as stimulus for increasing blood vessel size in patients with end-stage renal disease (ESRD) and may promote maturation of AVFs in the upper limb when applied postoperatively. However, it is unknown if forearm exercise increases blood vessel size pre-operatively, which may contribute to more distal AVF creation and raise success rates of AVF surgery...
November 15, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29142082/nonalcoholic-fatty-liver-disease-in-spinal-and-bulbar-muscular-atrophy
#8
Robert D Guber, Varun Takyar, Angela Kokkinis, Derrick A Fox, Hawwa Alao, Ilona Kats, Dara Bakar, Alan T Remaley, Stephen M Hewitt, David E Kleiner, Chia-Ying Liu, Colleen Hadigan, Kenneth H Fischbeck, Yaron Rotman, Christopher Grunseich
OBJECTIVE: To determine the prevalence and features of fatty liver disease in spinal and bulbar muscular atrophy (SBMA). METHODS: Two groups of participants with SBMA were evaluated. In the first group, 22 participants with SBMA underwent laboratory analysis and liver imaging. In the second group, 14 participants with SBMA were compared to 13 female carriers and 23 controls. Liver biopsies were done in 4 participants with SBMA. RESULTS: Evidence of fatty liver disease was detected by magnetic resonance spectroscopy in all participants with SBMA in the first group, with an average dome intrahepatic triacylglycerol of 27% (range 6%-66%, ref ≤5...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29130373/book-review-youval-rotman-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-rotman-youval-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-harvard-university-press-cambridge-ma-2016-256-pp-9780674057616-29-95-hbk
#9
https://www.readbyqxmd.com/read/29127000/drug-delivery-systems-functionalized-with-bone-mineral-seeking-agents-for-bone-targeted-therapeutics
#10
REVIEW
S G Rotman, D W Grijpma, R G Richards, T F Moriarty, D Eglin, O Guillaume
No abstract text is available yet for this article.
November 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29123645/beerdecoded-the-open-beer-metagenome-project
#11
Jonathan Sobel, Luc Henry, Nicolas Rotman, Gianpaolo Rando
Next generation sequencing has radically changed research in the life sciences, in both academic and corporate laboratories. The potential impact is tremendous, yet a majority of citizens have little or no understanding of the technological and ethical aspects of this widespread adoption. We designed BeerDeCoded as a pretext to discuss the societal issues related to genomic and metagenomic data with fellow citizens, while advancing scientific knowledge of the most popular beverage of all. In the spirit of citizen science, sample collection and DNA extraction were carried out with the participation of non-scientists in the community laboratory of Hackuarium, a not-for-profit organisation that supports unconventional research and promotes the public understanding of science...
2017: F1000Research
https://www.readbyqxmd.com/read/29022055/illness-perceptions-are-associated-with-quality-of-life-in-patients-with-fibrous-dysplasia
#12
B C J Majoor, C D Andela, C R Quispel, M Rotman, P D S Dijkstra, N A T Hamdy, A A Kaptein, N M Appelman-Dijkstra
Fibrous dysplasia (FD) is a rare bone disorder in which normal bone is replaced by fibrous tissue resulting in pain, deformities, pathological fractures or asymptomatic disease. Illness perceptions are patients' cognitions and emotions about their illness and its treatment, which may impact on Quality of Life (QoL). Here, we explore illness perceptions in patients with FD compared to other disorders, identify factors associated with illness perceptions and evaluate their relationship with QoL. Ninety-seven out of 138 eligible patients from the LUMC FD cohort completed the Illness Perception Questionnaire-Revised (IPQ-R) and the Short Form-36 (SF-36)...
October 11, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28992069/local-delivery-of-liposomal-prednisolone-leads-to-an-anti-inflammatory-profile-in-renal-ischaemia-reperfusion-injury-in-the-rat
#13
Carla M A van Alem, Mark Boonstra, Jurriën Prins, Taisiya Bezhaeva, Mieke F van Essen, Jurjen M Ruben, Alexander L Vahrmeijer, Eric P van der Veer, Johan W de Fijter, Marlies E Reinders, Onno Meijer, Josbert M Metselaar, Cees van Kooten, Joris I Rotmans
Background: Treatment of inflammatory kidney diseases with systemic high-dose glucocorticoids (GCs) has severe side effects. Liposomal encapsulation could facilitate local delivery of GCs to the inflamed kidney, as liposomes encapsulate their payload until extravasation at sites of inflammation, potentially resulting in local bioactivity. Our aim was to evaluate the ability of liposomes to accumulate locally after renal ischaemia-reperfusion injury in the rat and to study its effect on macrophages...
July 8, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28899189/book-review-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-by-rotman-youval-cambridge-harvard-university-press-2016-xii-256-pp-39-95-hardcover
#14
https://www.readbyqxmd.com/read/28860634/deficiency-of-tlr4-homologue-rp105-aggravates-outward-remodeling-in-a-murine-model-of-arteriovenous-fistula-failure
#15
Taisiya Bezhaeva, ChunYu Wong, Margreet R de Vries, Eric P van der Veer, Carla M A van Alem, Ivo Que, Reshma A Lalai, Anton-Jan van Zonneveld, Joris I Rotmans, Paul H A Quax
Arteriovenous access dysfunction is a major cause of morbidity for hemodialysis patients. The pathophysiology of arteriovenous fistula (AVF) maturation failure is associated with inflammation, impaired outward remodeling (OR) and intimal hyperplasia. RP105 is a critical physiologic regulator of TLR4 signaling in numerous cell types. In the present study, we investigated the impact of RP105 on AVF maturation, and defined cell-specific effects of RP105 on macrophages and vascular smooth muscle cells (VSMCs). Overall, RP105(-/-) mice displayed a 26% decrease in venous OR...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28853699/successful-therapy-with-mycophenolic-acid-in%C3%A2-a-membranous-glomerulonephritis-due-to%C3%A2-kimura-disease%C3%A2
#16
Julien Gaillard, Samuel Rotman, Christophe Girardet, François Spertini
Kimura disease (KD) is a rare inflammatory soft tissue disorder of unknown origin most frequent in Asians, the prevalence of which is growing in Western countries. Painless papules and/or nodules with a predilection for the head and the neck region, lymphadenopathies, parotid gland involvement, eosinophilia, and raised IgE levels are parts of its presentation. Renal involvement with various forms of glomerulonephritis, including membranous nephropathy (MN), can occur and is generally associated with a proteinuria that encompasses nephrotic syndrome...
October 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28795621/self-inflicted-wrist-injuries-masquerading-as-scaphoid-fractures-in-military-recruits
#17
Assaf Kadar, Dani Rotman, Haggai Schermann
No abstract text is available yet for this article.
August 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28696609/-the-role-of-medical-autopsies-as-a-quality-control-of-patients-management-in-internal-medicine-units
#18
Samuel Rotman, Thomas Zaugg, Pierre-Alexandre Bart
The number of medical autopsies has declined in recent decades due to the development of imaging techniques and some risks linked to autopsies. However, the contribution of autopsy is diagnostically significant, even better than new technologies currently available. It is thus a good indicator of quality, but also a training tool, and has a significant impact in the grieving process. At the CHUV, under the leadership of Pathology Department, institutional projects have been implemented in order to increase the number of autopsies, including a pre- and post-graduate training and systematic request for autopsy, with significant gain for clinicians and pathologists, but also for families who get systematic and customized return results...
November 23, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28669689/effects-of-erythropoietin-on-cycling-performance-of-well-trained-cyclists-a-double-blind-randomised-placebo-controlled-trial
#19
Jules A A C Heuberger, Joris I Rotmans, Pim Gal, Frederik E Stuurman, Juliëtte van 't Westende, Titiaan E Post, Johannes M A Daniels, Matthijs Moerland, Peter L J van Veldhoven, Marieke L de Kam, Herman Ram, Olivier de Hon, Jelle J Posthuma, Jacobus Burggraaf, Adam F Cohen
BACKGROUND: Substances that potentially enhance performance (eg, recombinant human erythropoietin [rHuEPO]) are considered doping and are therefore forbidden in sports; however, the scientific evidence behind doping is frequently weak. We aimed to determine the effects of rHuEPO treatment in well trained cyclists on maximal, submaximal, and race performance and on safety, and to present a model clinical study for doping research on other substances. METHODS: We did this double-blind, randomised, placebo-controlled trial at the Centre for Human Drug Research in Leiden (Netherlands)...
August 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28666915/dr-norman-chater-and-chater-s-point
#20
REVIEW
Lauren E Rotman, Mark R Harrigan
Dr. Norman Chater, a University of California San Francisco-trained microvascular neurosurgeon, dedicated his career to the development of surgical bypass techniques. His work contributed to advancements in microvascular anatomy and the development of cerebral revascularization techniques. He identified Chater's point, an extracranial landmark that marks the posterior extent of the Sylvian fissure, which on craniectomy reliably exposes vessels of the angular gyrus, the vasculature found to be most appropriate for bypass procedures owing to its accessibility and vascular diameter...
October 2017: World Neurosurgery
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