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https://www.readbyqxmd.com/read/28102512/anti-phospholipid-syndrome-associated-with-schizophrenia-description-of-five-patients-and-review-of-the-literature
#1
Pikman Regina, Rotman Pnina, Aiman Natur, Levy Yair
Anti-phospholipid syndrome is an autoimmune disorder characterized by anti-phospholipid antibodies, arterial and venous thrombosis, pregnancy morbidity, and various neurological manifestations including psychiatric disorders. Higher incidence of various autoimmune disorders was found in schizophrenia. In addition, an association between the presence of anti-phospholipid antibodies and schizophrenia or psychosis was previously described, mainly as case reports. Although initially believed to be a result of neuroleptic treatment, the reasons for this association remain obscure...
January 19, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28081186/mechanical-compression-effects-on-the-secretion-of-vwf-and-il-8-by-cultured-human-vein-endothelium
#2
Dar Weiss, Sharon Avraham, Ruth Guttlieb, Lee Gasner, Alina Lotman, Oren M Rotman, Shmuel Einav
Short peripheral catheters are ubiquitous in today's healthcare environment enabling effective delivery of fluids and medications directly into a patient's vasculature. However, complications related to their use, such as short peripheral catheter thrombophlebitis (SPCT), affect up to 80% of hospitalized patients. While indwelling within the vein, the catheters exert prolonged constant pressure upon the endothelium which can trigger inflammation processes. We have developed and studied an in-vitro model of cultured endothelial cells subjected to mechanical compression of modular self-designed weights, and explored their inflammatory response by quantification of two key biomarkers- vWF and IL-8...
2017: PloS One
https://www.readbyqxmd.com/read/28074540/complications-of-percutaneous-liver-biopsy-with-klatskin-needles-a-36-year-single-centre-experience
#3
V Takyar, O Etzion, T Heller, D E Kleiner, Y Rotman, M G Ghany, N Fryzek, V H Williams, E Rivera, S Auh, T J Liang, J H Hoofnagle, C Koh
BACKGROUND: Liver biopsy is the gold standard in evaluating liver diseases but is susceptible to complications. Safety data on aspiration needle biopsies remain limited. AIM: To evaluate the safety of percutaneous liver biopsy performed with Klatskin needle. METHODS: Clinical and biochemical data were retrospectively retrieved from sequential subjects who underwent liver biopsy with Klatskin needle from 1978 to 2015. Subjects with complications underwent thorough chart reviews for hospital course...
January 10, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28024838/special-issue-on-biofluid-mechanics-of-multitude-pathways-from-cellular-to-organ
#4
EDITORIAL
Shmuel Einav, Danny Bluestein, Oren M Rotman
No abstract text is available yet for this article.
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27989436/gene-architectures-that-minimize-cost-of-gene-expression
#5
Idan Frumkin, Dvir Schirman, Aviv Rotman, Fangfei Li, Liron Zahavi, Ernest Mordret, Omer Asraf, Song Wu, Sasha F Levy, Yitzhak Pilpel
Gene expression burdens cells by consuming resources and energy. While numerous studies have investigated regulation of expression level, little is known about gene design elements that govern expression costs. Here, we ask how cells minimize production costs while maintaining a given protein expression level and whether there are gene architectures that optimize this process. We measured fitness of ∼14,000 E. coli strains, each expressing a reporter gene with a unique 5' architecture. By comparing cost-effective and ineffective architectures, we found that cost per protein molecule could be minimized by lowering transcription levels, regulating translation speeds, and utilizing amino acids that are cheap to synthesize and that are less hydrophobic...
January 5, 2017: Molecular Cell
https://www.readbyqxmd.com/read/27869302/brain-function-is-linked-to-ldl-cholesterol-in-older-adults-with-cardiovascular-risk
#6
Liesel-Ann C Meusel, Nicole D Anderson, Matthew D Parrott, William Yuen, Ekaterina Tchistiakova, Bradley J MacIntosh, Sid Feldman, Carol E Greenwood
OBJECTIVES: To determine how cardiovascular risk is associated with working memory task performance and task-related suppression of default-mode network (DMN) activity in cognitively intact older adults. DESIGN: A cross-sectional functional magnetic resonance imaging study of older adults with cardiovascular risk factors. SETTING: Rotman Research Institute, Baycrest Health Sciences. PARTICIPANTS: Thirty older adults with cardiovascular risk factors...
November 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27866677/pressure-drop-and-arterial-compliance-two-arterial-parameters-in-one-measurement
#7
Oren M Rotman, Uri Zaretsky, Avraham Shitzer, Shmuel Einav
Coronary artery pressure-drop and distensibility (compliance) are two major, seemingly unrelated, parameters in the cardiovascular clinical setting, which are indicative of coronary arteries patency and atherosclerosis severity. While pressure drop is related to flow, and therefore serves as a functional indicator of a stenosis severity, the arterial distensibility is indicative of the arterial stiffness, and hence the arterial wall composition. In the present study, we hypothesized that local pressure drops are dependent on the arterial distensibility, and hence can provide information on both indices...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27866674/quantitative-t2-mapping-for-detection-and-quantification-of-thrombophlebitis-in-a-rabbit-model
#8
Dar Weiss, Oren M Rotman, Shmuel Einav
Short peripheral catheter thrombophlebitis (SPCT), a sterile inflammation of the vein wall, is the most common complication associated with short peripheral catheters (SPCs) and affects up to 80% of hospitalized patients receiving IV therapy. Extensive research efforts have been devoted for improvement and optimization of the catheter material, but means for examination of any novel design are limited, inaccurate and require costly comprehensive pre-clinical and clinical trials. Therefore, there is a conclusive need for a reliable quantitative method for evaluation of SPCT, in particular for research purposes examining the thrombophlebitis-related symptoms of any novel catheter design...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27860368/in-vitro-and-biomechanical-screening-of-polyethylene-glycol-and-poly-trimethylene-carbonate-block-copolymers-for-annulus-fibrosus-repair
#9
Rose G Long, Stijn G Rotman, Warren W Hom, Dylan J Assael, Dirk W Grijpma, James C Iatridis
Herniated intervertebral discs are a common cause of back and neck pain. There is an unmet clinical need to seal annulus fibrosus (AF) defects, since discectomy surgeries address acute pain but are complicated by reherniation and recurrent pain. Copolymers of polyethylene glycol with trimethylene carbonate (TMC) and hexamathylene diisocyanate end-groups were formulated as AF sealants since the hexamathylene diisocyanate form covalent bonds with native AF tissue. TMC adhesives were evaluated and optimized using the design criteria: stable size, strong adherence to AF tissue, high cytocompatibility, restoration of intervertebral disc biomechanics to intact levels following in situ repair, and low extrusion risk...
November 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27799484/renal-fanconi-syndrome-and-hypophosphatemic-rickets-in-the-absence-of-xenotropic-and-polytropic-retroviral-receptor-in-the-nephron
#10
Camille Ansermet, Matthias B Moor, Gabriel Centeno, Muriel Auberson, Dorothy Zhang Hu, Roland Baron, Svetlana Nikolaeva, Barbara Haenzi, Natalya Katanaeva, Ivan Gautschi, Vladimir Katanaev, Samuel Rotman, Robert Koesters, Laurent Schild, Sylvain Pradervand, Olivier Bonny, Dmitri Firsov
Tight control of extracellular and intracellular inorganic phosphate (Pi) levels is critical to most biochemical and physiologic processes. Urinary Pi is freely filtered at the kidney glomerulus and is reabsorbed in the renal tubule by the action of the apical sodium-dependent phosphate transporters, NaPi-IIa/NaPi-IIc/Pit2. However, the molecular identity of the protein(s) participating in the basolateral Pi efflux remains unknown. Evidence has suggested that xenotropic and polytropic retroviral receptor 1 (XPR1) might be involved in this process...
October 31, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27777734/why-fly-the-extra-mile-latitudinal-trend-in-migratory-fuel-deposition-rate-as-driver-of-trans-equatorial-long-distance-migration
#11
Yaara Aharon-Rotman, Ken Gosbell, Clive Minton, Marcel Klaassen
Trans-equatorial long-distance migrations of high-latitude breeding animals have been attributed to narrow ecological niche widths. We suggest an alternative hypothesis postulating that trans-equatorial migrations result from a possible increase in the rate at which body stores to fuel migration are deposited with absolute latitude; that is, longer, migrations away from the breeding grounds surpassing the equator may actually enhance fueling rates on the nonbreeding grounds and therewith the chance of a successful, speedy and timely migration back to the breeding grounds...
September 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27756791/exploring-new-endpoints-for-patients-with-heart-failure-with-preserved-ejection-fraction
#12
Javed Butler, Carine E Hamo, James E Udelson, Bertram Pitt, Clyde Yancy, Sanjiv J Shah, Patrice Desvigne-Nickens, Harold S Bernstein, Richard L Clark, Christophe Depre, Wilfried Dinh, Andrew Hamer, Patricia Kay-Mugford, Frank Kramer, Martin Lefkowitz, Kelly Lewis, Juan Maya, Simon Maybaum, Mahesh J Patel, Pia S Pollack, Lothar Roessig, Sarit Rotman, Afshin Salsali, J Jason Sims, Michele Senni, Giuseppe Rosano, Preston Dunnmon, Norman Stockbridge, Stefan D Anker, Michael R Zile, Mihai Gheorghiade
The epidemiological, clinical, and societal implications of the heart failure (HF) epidemic cannot be overemphasized. Approximately half of all HF patients have HF with preserved ejection fraction (HFpEF). HFpEF is largely a syndrome of the elderly, and with aging of the population, the proportion of patients with HFpEF is expected to grow. Currently, there is no drug known to improve mortality or hospitalization risk for these patients. Besides mortality and hospitalization, it is imperative to realize that patients with HFpEF have significant impairment in their functional capacity and their quality of life on a daily basis, underscoring the need for these parameters to ideally be incorporated within a regulatory pathway for drug approval...
November 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27688260/echocardiographic-associates-of-atrial-fibrillation-in-end-stage-renal-disease
#13
Liselotte C R Hensen, Victoria Delgado, Suzanne E van Wijngaarden, Melissa Leung, Mihaly K de Bie, Maurits S Buiten, Martin J Schalij, Jos J Van de Kerkhof, Ton J Rabelink, Joris I Rotmans, J Wouter Jukema, Jeroen J Bax
BACKGROUND: The prevalence of atrial fibrillation (AF) in end-stage renal disease (ESRD) patients is relatively high. The present study evaluated the association between left atrial (LA) remodelling, including an increased size and myocardial fibrosis, and slow LA conduction and the occurrence of AF. METHODS: In 171 ESRD patients enrolled in the Implantable Cardioverter Defibrillators in Dialysis patients (ICD2) trial, the LA dimensions, LA conduction delay [as reflected by the time difference between P-wave onset on surface electrocardiogram and A'-wave on tissue Doppler imaging (PA-TDI)] and LA function were compared between patients who exhibited AF versus patients without AF...
September 29, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27683044/blockade-of-c5-in-severe-acute-postinfectious-glomerulonephritis-associated-with-anti-factor-h-autoantibody
#14
Hassib Chehade, Samuel Rotman, Véronique Frémeaux-Bacchi, Vincent Aubert, Salima Sadallah, Loukia Sifaki, Rémi Salomon, Manuel Pascual
Activation of the complement cascade plays an important role in the pathogenesis of postinfectious glomerulonephritis. We report successful terminal complement pathway blockade using an anti-C5 monoclonal antibody (eculizumab) in an 8-year-old child with severe acute postinfectious glomerulonephritis requiring hemodialysis. The child presented with clinical, serologic, and histopathologic criteria for diffuse crescentic postinfectious glomerulonephritis. Complement measurements showed low C3 and C4 levels, with increased SC5b-9 titers...
September 24, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27646933/current-and-upcoming-pharmacotherapy-for-non-alcoholic-fatty-liver-disease
#15
REVIEW
Yaron Rotman, Arun J Sanyal
Given the high prevalence and rising incidence of non-alcoholic fatty liver disease (NAFLD), the absence of approved therapies is striking. Although the mainstay of treatment of NAFLD is weight loss, it is hard to maintain, prompting the need for pharmacotherapy as well. A greater understanding of disease pathogenesis in recent years was followed by development of new classes of medications, as well as potential repurposing of currently available agents. NAFLD therapies target four main pathways. The dominant approach is targeting hepatic fat accumulation and the resultant metabolic stress...
January 2017: Gut
https://www.readbyqxmd.com/read/27634422/effect-of-abdominopelvic-abscess-drain-size-on-drainage-time-and-probability-of-occlusion
#16
Jessica A Rotman, George I Getrajdman, Majid Maybody, Joseph P Erinjeri, Hooman Yarmohammadi, Constantinos T Sofocleous, Stephen B Solomon, F Edward Boas
BACKGROUND: The purpose of this study is to determine whether larger abdominopelvic abscess drains reduce the time required for abscess resolution or the probability of tube occlusion. METHODS: 144 consecutive patients who underwent abscess drainage at a single institution were reviewed retrospectively. RESULTS: Larger initial drain size did not reduce drainage time, drain occlusion, or drain exchanges (P > .05). Subgroup analysis did not find any type of collection that benefitted from larger drains...
August 17, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27604583/promoting-tropoelastin-expression-in-arterial-and-venous-vascular-smooth-muscle-cells-and-fibroblasts-for-vascular-tissue-engineering
#17
Tonia C Rothuizen, Raymond Kemp, Jacques M G J Duijs, Hetty C de Boer, Roel Bijkerk, Eric P van der Veer, Lorenzo Moroni, Anton Jan van Zonneveld, Anthony S Weiss, Ton J Rabelink, Joris I Rotmans
Elastin, critical for its structural and regulatory functions, is a missing link in vascular tissue engineering. Several elastin-inducting compounds have previously been reported, but their relative efficiency in promoting elastogenesis by adult arterial and venous vascular smooth muscle cells (VSMCs) and fibroblasts, four main vascular and elastogenic cells, has not been described. In addition to elasto-inductive substances, microRNA-29a was recently established as a potent post-transcriptional inhibitor of elastogenesis...
September 28, 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27544992/-a-paradigm-shift-in-the-perception-of-health-maintenance-from-increasing-physical-activity-to-decreasing-physical-inactivity
#18
REVIEW
Dani Rotman, Naama Constantini
Modern man spends most of his waking hours (50-70%) in one form or another of sedentary behavior, defined as activity conducted in a sitting or reclining position involving low energy expenditure. The remaining waking hours are spent performing low intensity physical activity (25-45%) and medium-high intensity physical activity (less than 5%): Despite this distribution, medical research has focused on the impact of increasing medium-high intensity physical activity and many health organizations' recommendations are in accordance...
June 2016: Harefuah
https://www.readbyqxmd.com/read/27520615/mobile-applications-for-control-and-self-management-of-diabetes-a-systematic-review
#19
Petra Povalej Brzan, Eva Rotman, Majda Pajnkihar, Petra Klanjsek
Mobile applications (apps) can be very useful software on smartphones for all aspects of people's lives. Chronic diseases, such as diabetes, can be made manageable with the support of mobile apps. Applications on smartphones can also help people with diabetes to control their fitness and health. A systematic review of free apps in the English language for smartphones in three of the most popular mobile app stores: Google Play (Android), App Store (iOS) and Windows Phone Store, was performed from November to December 2015...
September 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27460883/liposomal-prednisolone-inhibits-vascular-inflammation-and-enhances-venous-outward-remodeling-in-a-murine-arteriovenous-fistula-model
#20
ChunYu Wong, Taisiya Bezhaeva, Tonia C Rothuizen, Josbert M Metselaar, Margreet R de Vries, Floris P R Verbeek, Alexander L Vahrmeijer, Anouk Wezel, Anton-Jan van Zonneveld, Ton J Rabelink, Paul H A Quax, Joris I Rotmans
Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulate in the post-anastomotic area of the venous outflow tract in which the vascular pathology is most prominent in failed AVFs...
2016: Scientific Reports
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