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Javed Butler, Carine E Hamo, James E Udelson, Bertram Pitt, Clyde Yancy, Sanjiv J Shah, Patrice Desvigne-Nickens, Harold S Bernstein, Richard L Clark, Christophe Depre, Wilfried Dinh, Andrew Hamer, Patricia Kay-Mugford, Frank Kramer, Martin Lefkowitz, Kelly Lewis, Juan Maya, Simon Maybaum, Mahesh J Patel, Pia S Pollack, Lothar Roessig, Sarit Rotman, Afshin Salsali, J Jason Sims, Michele Senni, Giuseppe Rosano, Preston Dunnmon, Norman Stockbridge, Stefan D Anker, Michael R Zile, Mihai Gheorghiade
The epidemiological, clinical, and societal implications of the heart failure (HF) epidemic cannot be overemphasized. Approximately half of all HF patients have HF with preserved ejection fraction (HFpEF). HFpEF is largely a syndrome of the elderly, and with aging of the population, the proportion of patients with HFpEF is expected to grow. Currently, there is no drug known to improve mortality or hospitalization risk for these patients. Besides mortality and hospitalization, it is imperative to realize that patients with HFpEF have significant impairment in their functional capacity and their quality of life on a daily basis, underscoring the need for these parameters to ideally be incorporated within a regulatory pathway for drug approval...
November 2016: Circulation. Heart Failure
Liselotte C R Hensen, Victoria Delgado, Suzanne E van Wijngaarden, Melissa Leung, Mihaly K de Bie, Maurits S Buiten, Martin J Schalij, Jos J Van de Kerkhof, Ton J Rabelink, Joris I Rotmans, J Wouter Jukema, Jeroen J Bax
BACKGROUND: The prevalence of atrial fibrillation (AF) in end-stage renal disease (ESRD) patients is relatively high. The present study evaluated the association between left atrial (LA) remodelling, including an increased size and myocardial fibrosis, and slow LA conduction and the occurrence of AF. METHODS: In 171 ESRD patients enrolled in the Implantable Cardioverter Defibrillators in Dialysis patients (ICD2) trial, the LA dimensions, LA conduction delay [as reflected by the time difference between P-wave onset on surface electrocardiogram and A'-wave on tissue Doppler imaging (PA-TDI)] and LA function were compared between patients who exhibited AF versus patients without AF...
September 29, 2016: Nephrology, Dialysis, Transplantation
Hassib Chehade, Samuel Rotman, Véronique Frémeaux-Bacchi, Vincent Aubert, Salima Sadallah, Loukia Sifaki, Rémi Salomon, Manuel Pascual
Activation of the complement cascade plays an important role in the pathogenesis of postinfectious glomerulonephritis. We report successful terminal complement pathway blockade using an anti-C5 monoclonal antibody (eculizumab) in an 8-year-old child with severe acute postinfectious glomerulonephritis requiring hemodialysis. The child presented with clinical, serologic, and histopathologic criteria for diffuse crescentic postinfectious glomerulonephritis. Complement measurements showed low C3 and C4 levels, with increased SC5b-9 titers...
September 24, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Yaron Rotman, Arun J Sanyal
Given the high prevalence and rising incidence of non-alcoholic fatty liver disease (NAFLD), the absence of approved therapies is striking. Although the mainstay of treatment of NAFLD is weight loss, it is hard to maintain, prompting the need for pharmacotherapy as well. A greater understanding of disease pathogenesis in recent years was followed by development of new classes of medications, as well as potential repurposing of currently available agents. NAFLD therapies target four main pathways. The dominant approach is targeting hepatic fat accumulation and the resultant metabolic stress...
September 19, 2016: Gut
Jessica A Rotman, George I Getrajdman, Majid Maybody, Joseph P Erinjeri, Hooman Yarmohammadi, Constantinos T Sofocleous, Stephen B Solomon, F Edward Boas
BACKGROUND: The purpose of this study is to determine whether larger abdominopelvic abscess drains reduce the time required for abscess resolution or the probability of tube occlusion. METHODS: 144 consecutive patients who underwent abscess drainage at a single institution were reviewed retrospectively. RESULTS: Larger initial drain size did not reduce drainage time, drain occlusion, or drain exchanges (P > .05). Subgroup analysis did not find any type of collection that benefitted from larger drains...
August 17, 2016: American Journal of Surgery
Tonia C Rothuizen, Raymond Kemp, Jacques M G J Duijs, Hetty C De Boer, Roel Bijkerk, Eric P Van der Veer, Lorenzo Moroni, Anton Jan Van Zonneveld, Anthony S Weiss, Ton J Rabelink, Joris I Rotmans
BACKGROUND: Elastin, critical for its structural and regulatory functions, is a missing link in vascular tissue engineering. Several elastin-inducting compounds have previously been reported, but their relative efficiency in promoting elastogenesis by adult arterial and venous vascular smooth muscle cells (VSMCs) and fibroblasts, four main vascular and elastogenic cells, has not been described. In addition to elasto-inductive substances, microRNA-29a was recently established as a potent post-transcriptional inhibitor of elastogenesis...
September 7, 2016: Tissue Engineering. Part C, Methods
Dani Rotman, Naama Constantini
Modern man spends most of his waking hours (50-70%) in one form or another of sedentary behavior, defined as activity conducted in a sitting or reclining position involving low energy expenditure. The remaining waking hours are spent performing low intensity physical activity (25-45%) and medium-high intensity physical activity (less than 5%): Despite this distribution, medical research has focused on the impact of increasing medium-high intensity physical activity and many health organizations' recommendations are in accordance...
June 2016: Harefuah
Petra Povalej Brzan, Eva Rotman, Majda Pajnkihar, Petra Klanjsek
Mobile applications (apps) can be very useful software on smartphones for all aspects of people's lives. Chronic diseases, such as diabetes, can be made manageable with the support of mobile apps. Applications on smartphones can also help people with diabetes to control their fitness and health. A systematic review of free apps in the English language for smartphones in three of the most popular mobile app stores: Google Play (Android), App Store (iOS) and Windows Phone Store, was performed from November to December 2015...
September 2016: Journal of Medical Systems
ChunYu Wong, Taisiya Bezhaeva, Tonia C Rothuizen, Josbert M Metselaar, Margreet R de Vries, Floris P R Verbeek, Alexander L Vahrmeijer, Anouk Wezel, Anton-Jan van Zonneveld, Ton J Rabelink, Paul H A Quax, Joris I Rotmans
Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulate in the post-anastomotic area of the venous outflow tract in which the vascular pathology is most prominent in failed AVFs...
2016: Scientific Reports
Vivian Rotman, Alysson Roncally Carvalho, Rosana Souza Rodrigues, Denise Machado Medeiros, Eduardo Costa Pinto, Fernando Augusto Bozza, Carlos Roberto Ribeiro Carvalho
BACKGROUND: Ventilation with low tidal volume (VT) is well recognized as a protective approach to patients with acute respiratory distress syndrome (ARDS), but the optimal level of positive end-expiratory pressure (PEEP) remains uncertain. This study aims to evaluate two protective ventilatory strategies sequentially applied in patients with early ARDS. METHODS: In this prospective cohort study, fifteen patients were ventilated during 24 h with positive end-expiratory pressure (PEEP) adjusted according to the ARDSnet low-PEEP table (ARDSnet-24 h)...
2016: BMC Anesthesiology
N Ruhrman-Shahar, J Torres-Ruiz, P Rotman-Pikielny, Y Levy
Autoimmune reaction after vaccination is sporadically reported in the medical literature. Vaccinations are generally safe and have an important role in eradicating endemic diseases worldwide. Nevertheless, the question arises as to whether there is a possibility of post-vaccination autoimmune phenomena. The anti-tetanus vaccine is being used since 1924, and it is part of the recommended immunization schedules for children. There are few reports of autoimmune diseases, such as rheumatoid arthritis and anti-phospholipid syndrome after anti-tetanus vaccination...
July 19, 2016: Immunologic Research
Omer Gendelman, Naim Mahroum, Doron Comaneshter, Pnina Rotman-Pikielny, Arnon D Cohen, Howard Amital, Michael Sherf
The association between hepatitis B and autoimmune disorders has been intriguing for decades. Many reports have speculated on the possible linkage between these two conditions, yet never before data driven from a large national database was utilized in order to investigate this issue. The objective of this study was to investigate the association between SLE and hepatitis B carrier state. Patients with SLE were compared with age- and sex-matched controls regarding the proportion of hepatitis B carrier state in a case-control study...
July 16, 2016: Immunologic Research
Ella Rotman, David M Webber, H Steven Seifert
UNLABELLED: Many pathogens use homologous recombination to vary surface antigens in order to avoid immune surveillance. Neisseria gonorrhoeae, the bacterium responsible for the sexually transmitted infection gonorrhea, achieves this in part by changing the sequence of the major subunit of the type IV pilus in a process termed pilin antigenic variation (Av). The N. gonorrhoeae chromosome contains one expression locus (pilE) and many promoterless, partial-coding silent copies (pilS) that act as reservoirs for variant pilin information...
September 15, 2016: Journal of Bacteriology
Michał Harciarek, Jarosław Michałowski, Bogdan Biedunkiewicz, John Williamson, Alicja Dębska-Ślizień, Bolesław Rutkowski, Kenneth M Heilman
OBJECTIVE: Dialyzed patients with end-stage renal disease (ESRD) have been reported to have several neurobehavioral impairments that are often accompanied by structural and functional abnormalities of frontal-subcortical networks. Whereas the anterior attentional-intentional systems responsible for the allocation of attention and preparation for action (intention) are mediated by these frontal-subcortical networks, these functions have not been specifically investigated in this population...
August 2016: Brain and Cognition
Karim Abid, Katayoun Afshar, Enzo Fontana, Julien Ducry, Samuel Rotman, Edouard Stauffer, Florence Fellmann, Oliver Tschopp, Zahurul A Bhuiyan, Eric Grouzmann
No abstract text is available yet for this article.
July 2016: Clinical Chemistry
Yaara Aharon-Rotman, Katherine L Buchanan, Nicholas J Clark, Marcel Klaassen, William A Buttemer
Migratory birds make decisions about how far to travel based on cost-benefit trade-offs. However, in many cases the net effect of these trade-offs is unclear. We sought to address this question by measuring feather corticosterone (CORTf), leucocyte profile, avian malaria parasite prevalence and estimating fueling rates in three spatially segregated wintering populations of the migratory shorebird ruddy turnstone Arenaria interpres during their stay in the winter habitat. These birds fly from the high-Arctic breeding ground to Australia, but differ in that some decide to end their migration early (Broome, Western Australia), whereas others travel further to either South Australia or Tasmania...
October 2016: Oecologia
Chava L Ramspek, Hakan Nacak, Merel van Diepen, Marjolijn van Buren, Raymond T Krediet, Joris I Rotmans, Friedo W Dekker
BACKGROUND: Monitoring of renal function is important in patients with chronic kidney disease progressing towards end-stage renal failure, both for timing the start of renal replacement therapy and for determining the prognosis on dialysis. Thus far, studies on associations between estimated glomerular filtration rate (eGFR) measurements in the pre-dialysis stage and mortality on dialysis have shown no or even inverse relations, which may result from the poor validity of serum creatinine-based estimation equations for renal function in pre-dialysis patients...
June 16, 2016: Nephrology, Dialysis, Transplantation
Xu-Dong Bai, Xian-Ling Liang, Jian-Ping Li, Kun Wang, Jun-Ping Geng, Rong-Hong Jin
Recently, vortex beam carrying orbital angular momentum (OAM) for radio communications has attracted much attention for its potential of transmitting multiple signals simultaneously at the same frequency, which can be used to increase the channel capacity. However, most of the methods for getting multi-mode OAM radio beams remain up to now mainly at simulation level, since their implementations are of complicated structure and very high cost. This paper provides an effective design of generating five-mode OAM radio beams by using the Rotman lens-fed antenna array...
2016: Scientific Reports
H F Wunderink, E van der Meijden, C S van der Blij-de Brouwer, M J K Mallat, G W Haasnoot, E W van Zwet, E C J Claas, J W de Fijter, A C M Kroes, F Arnold, A Touzé, F H J Claas, J I Rotmans, M C W Feltkamp
Kidney transplant donors are currently not implicated in predicting BK polyomavirus (BKPyV) infection in kidney transplant recipients. It has been postulated, however, that BKPyV infection originates from the kidney allograft. Since BKPyV-seroreactivity correlates with BKPyV-replication and, therefore, might mirror the infectious load, we investigated whether BKPyV-seroreactivity of the donor predicts viremia and BKPyV-associated nephropathy (BKPyVAN) in the recipient. In a retrospective cohort of 407 living kidney donor-recipient pairs pretransplantation donor and recipient sera were tested for BKPyV IgG-levels and correlated with the occurrence of recipient BKPyV viremia and BKPyVAN within one year posttransplantation...
June 2, 2016: American Journal of Transplantation
Celine Q F Klessens, Tess D Woutman, Kimberley A M Veraar, Malu Zandbergen, Elisabeth J J Valk, Joris I Rotmans, Ron Wolterbeek, Jan A Bruijn, Ingeborg M Bajema
The reported prevalence of diabetic nephropathy (DN) among patients with diabetes varies widely. Most studies use the presence of microalbuminuria for clinical onset of DN in the absence of a histopathologic evaluation. In this autopsy study, we collected and analyzed data from a cohort of patients with type 1 or 2 diabetes and determined the prevalence of histologically proven DN in patients with or without clinical manifestations of renal disease. We also examined the distribution among histopathologic classes with respect to clinical parameters...
July 2016: Kidney International
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