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https://www.readbyqxmd.com/read/29142082/nonalcoholic-fatty-liver-disease-in-spinal-and-bulbar-muscular-atrophy
#1
Robert D Guber, Varun Takyar, Angela Kokkinis, Derrick A Fox, Hawwa Alao, Ilona Kats, Dara Bakar, Alan T Remaley, Stephen M Hewitt, David E Kleiner, Chia-Ying Liu, Colleen Hadigan, Kenneth H Fischbeck, Yaron Rotman, Christopher Grunseich
OBJECTIVE: To determine the prevalence and features of fatty liver disease in spinal and bulbar muscular atrophy (SBMA). METHODS: Two groups of participants with SBMA were evaluated. In the first group, 22 participants with SBMA underwent laboratory analysis and liver imaging. In the second group, 14 participants with SBMA were compared to 13 female carriers and 23 controls. Liver biopsies were done in 4 participants with SBMA. RESULTS: Evidence of fatty liver disease was detected by magnetic resonance spectroscopy in all participants with SBMA in the first group, with an average dome intrahepatic triacylglycerol of 27% (range 6%-66%, ref ≤5...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29130373/book-review-youval-rotman-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-rotman-youval-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-harvard-university-press-cambridge-ma-2016-256-pp-9780674057616-29-95-hbk
#2
https://www.readbyqxmd.com/read/29127000/drug-delivery-systems-functionalized-with-bone-mineral-seeking-agents-for-bone-targeted-therapeutics
#3
REVIEW
S G Rotman, D W Grijpma, R G Richards, T F Moriarty, D Eglin, O Guillaume
No abstract text is available yet for this article.
November 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29123645/beerdecoded-the-open-beer-metagenome-project
#4
Jonathan Sobel, Luc Henry, Nicolas Rotman, Gianpaolo Rando
Next generation sequencing has radically changed research in the life sciences, in both academic and corporate laboratories. The potential impact is tremendous, yet a majority of citizens have little or no understanding of the technological and ethical aspects of this widespread adoption. We designed BeerDeCoded as a pretext to discuss the societal issues related to genomic and metagenomic data with fellow citizens, while advancing scientific knowledge of the most popular beverage of all. In the spirit of citizen science, sample collection and DNA extraction were carried out with the participation of non-scientists in the community laboratory of Hackuarium, a not-for-profit organisation that supports unconventional research and promotes the public understanding of science...
2017: F1000Research
https://www.readbyqxmd.com/read/29022055/illness-perceptions-are-associated-with-quality-of-life-in-patients-with-fibrous-dysplasia
#5
B C J Majoor, C D Andela, C R Quispel, M Rotman, P D S Dijkstra, N A T Hamdy, A A Kaptein, N M Appelman-Dijkstra
Fibrous dysplasia (FD) is a rare bone disorder in which normal bone is replaced by fibrous tissue resulting in pain, deformities, pathological fractures or asymptomatic disease. Illness perceptions are patients' cognitions and emotions about their illness and its treatment, which may impact on Quality of Life (QoL). Here, we explore illness perceptions in patients with FD compared to other disorders, identify factors associated with illness perceptions and evaluate their relationship with QoL. Ninety-seven out of 138 eligible patients from the LUMC FD cohort completed the Illness Perception Questionnaire-Revised (IPQ-R) and the Short Form-36 (SF-36)...
October 11, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28992069/local-delivery-of-liposomal-prednisolone-leads-to-an-anti-inflammatory-profile-in-renal-ischaemia-reperfusion-injury-in-the-rat
#6
Carla M A van Alem, Mark Boonstra, Jurriën Prins, Taisiya Bezhaeva, Mieke F van Essen, Jurjen M Ruben, Alexander L Vahrmeijer, Eric P van der Veer, Johan W de Fijter, Marlies E Reinders, Onno Meijer, Josbert M Metselaar, Cees van Kooten, Joris I Rotmans
Background: Treatment of inflammatory kidney diseases with systemic high-dose glucocorticoids (GCs) has severe side effects. Liposomal encapsulation could facilitate local delivery of GCs to the inflamed kidney, as liposomes encapsulate their payload until extravasation at sites of inflammation, potentially resulting in local bioactivity. Our aim was to evaluate the ability of liposomes to accumulate locally after renal ischaemia-reperfusion injury in the rat and to study its effect on macrophages...
July 8, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28899189/book-review-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-by-rotman-youval-cambridge-harvard-university-press-2016-xii-256-pp-39-95-hardcover
#7
https://www.readbyqxmd.com/read/28860634/deficiency-of-tlr4-homologue-rp105-aggravates-outward-remodeling-in-a-murine-model-of-arteriovenous-fistula-failure
#8
Taisiya Bezhaeva, ChunYu Wong, Margreet R de Vries, Eric P van der Veer, Carla M A van Alem, Ivo Que, Reshma A Lalai, Anton-Jan van Zonneveld, Joris I Rotmans, Paul H A Quax
Arteriovenous access dysfunction is a major cause of morbidity for hemodialysis patients. The pathophysiology of arteriovenous fistula (AVF) maturation failure is associated with inflammation, impaired outward remodeling (OR) and intimal hyperplasia. RP105 is a critical physiologic regulator of TLR4 signaling in numerous cell types. In the present study, we investigated the impact of RP105 on AVF maturation, and defined cell-specific effects of RP105 on macrophages and vascular smooth muscle cells (VSMCs). Overall, RP105(-/-) mice displayed a 26% decrease in venous OR...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28853699/successful-therapy-with-mycophenolic-acid-in%C3%A2-a-membranous-glomerulonephritis-due-to%C3%A2-kimura-disease%C3%A2
#9
Julien Gaillard, Samuel Rotman, Christophe Girardet, François Spertini
Kimura disease (KD) is a rare inflammatory soft tissue disorder of unknown origin most frequent in Asians, the prevalence of which is growing in Western countries. Painless papules and/or nodules with a predilection for the head and the neck region, lymphadenopathies, parotid gland involvement, eosinophilia, and raised IgE levels are parts of its presentation. Renal involvement with various forms of glomerulonephritis, including membranous nephropathy (MN), can occur and is generally associated with a proteinuria that encompasses nephrotic syndrome...
August 30, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28795621/self-inflicted-wrist-injuries-masquerading-as-scaphoid-fractures-in-military-recruits
#10
Assaf Kadar, Dani Rotman, Haggai Schermann
No abstract text is available yet for this article.
August 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28696609/-the-role-of-medical-autopsies-as-a-quality-control-of-patients-management-in-internal-medicine-units
#11
Samuel Rotman, Thomas Zaugg, Pierre-Alexandre Bart
The number of medical autopsies has declined in recent decades due to the development of imaging techniques and some risks linked to autopsies. However, the contribution of autopsy is diagnostically significant, even better than new technologies currently available. It is thus a good indicator of quality, but also a training tool, and has a significant impact in the grieving process. At the CHUV, under the leadership of Pathology Department, institutional projects have been implemented in order to increase the number of autopsies, including a pre- and post-graduate training and systematic request for autopsy, with significant gain for clinicians and pathologists, but also for families who get systematic and customized return results...
November 23, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28669689/effects-of-erythropoietin-on-cycling-performance-of-well-trained-cyclists-a-double-blind-randomised-placebo-controlled-trial
#12
Jules A A C Heuberger, Joris I Rotmans, Pim Gal, Frederik E Stuurman, Juliëtte van 't Westende, Titiaan E Post, Johannes M A Daniels, Matthijs Moerland, Peter L J van Veldhoven, Marieke L de Kam, Herman Ram, Olivier de Hon, Jelle J Posthuma, Jacobus Burggraaf, Adam F Cohen
BACKGROUND: Substances that potentially enhance performance (eg, recombinant human erythropoietin [rHuEPO]) are considered doping and are therefore forbidden in sports; however, the scientific evidence behind doping is frequently weak. We aimed to determine the effects of rHuEPO treatment in well trained cyclists on maximal, submaximal, and race performance and on safety, and to present a model clinical study for doping research on other substances. METHODS: We did this double-blind, randomised, placebo-controlled trial at the Centre for Human Drug Research in Leiden (Netherlands)...
August 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28666915/dr-norman-chater-and-chater-s-point
#13
REVIEW
Lauren E Rotman, Mark R Harrigan
Dr. Norman Chater, a University of California San Francisco-trained microvascular neurosurgeon, dedicated his career to the development of surgical bypass techniques. His work contributed to advancements in microvascular anatomy and the development of cerebral revascularization techniques. He identified Chater's point, an extracranial landmark that marks the posterior extent of the Sylvian fissure, which on craniectomy reliably exposes vessels of the angular gyrus, the vasculature found to be most appropriate for bypass procedures owing to its accessibility and vascular diameter...
October 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28656678/mother-adolescent-dialogues-and-adolescents-behavior-problems-in-a-multicultural-sample-the-mediating-role-of-representations
#14
Efrat Sher-Censor, Nina Koren-Karie, Smadar Getzov, Pazit Rotman
This study examined whether the link between higher maternal sensitive guidance of emotional dialogues and fewer adolescent behavior problems is mediated by adolescents' more coherent representations of their mothers. The study also explored the consistency of this model across families from varied cultural backgrounds. Participants were 143 Jewish-Israeli mother-adolescent dyads from three cultural groups: immigrants from the Former Soviet Union, immigrants from Western countries, and native-born Israelis...
June 5, 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28579125/prognostic-implications-of-left-ventricular-global-longitudinal-strain-in-predialysis-and-dialysis-patients
#15
Liselotte C R Hensen, Kathleen Goossens, Victoria Delgado, Joris I Rotmans, J Wouter Jukema, Jeroen J Bax
Chronic kidney disease (CKD) is a worldwide growing epidemic associated with an increased risk of cardiovascular morbidity and mortality. Left ventricular (LV) global longitudinal strain (GLS) is a measure of LV systolic function associated with prognosis in the general population. However, little is known about the association between LV GLS and survival in patients with CKD. The aim of the present study was to investigate the prognostic implications of LV GLS in predialysis and dialysis patients specifically...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28541443/the-impact-of-multidisciplinary-care-on-early-morbidity-and-mortality-after-heart-transplantation
#16
Marie Schmidhauser, Julien Regamey, Nathalie Pilon, Manuel Pascual, Sam Rotman, Carlo Banfi, René Prêtre, Philippe Meyer, Jean-Philippe Antonietti, Roger Hullin
OBJECTIVES: The impact of multidisciplinary care on outcome after heart transplantation (HTx) remains unclear. METHODS: This retrospective study investigates the impact of multidisciplinary care on the primary end point 1-year all-cause mortality (ACM) and the secondary end point mean acute cellular rejection (ACR) grade within the first postoperative year. RESULTS: This study includes a total 140 HTx recipients (median age: 53.5 years; males: 80%; donor/recipient gender mismatch: 38...
September 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28530076/-osteoporosis-and-diabetes-in-which-way-are-they-related
#17
REVIEW
Osnat Tell-Lebanon, Pnina Rotman-Pikielny
Diabetes and osteoporosis are common diseases with growing prevalence in the aging population. Many recent studies have reported an association between diabetes mellitus and an increased osteoporotic fracture rate. Compared to control subjects, decreased bone mineral density has been observed in patients with type 1 diabetes mellitus, while those with type 2 diabetes display a unique skeletal phenotype of increased bone mineral density, but impaired architectural structure and mineral properties. Accumulation of advanced glycation end products changes collagen structure and suppression of bone turnover causes impairment of repair and adaptation mechanisms...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28470683/how-healthy-are-the-healthy-volunteers-penetrance-of-nafld-in-the-biomedical-research-volunteer-pool
#18
COMPARATIVE STUDY
Varun Takyar, Anand Nath, Andrea Beri, Ahmed M Gharib, Yaron Rotman
Healthy volunteers are crucial for biomedical research. Inadvertent inclusion of subjects with nonalcoholic fatty liver disease (NAFLD) as controls can compromise study validity and subject safety. Given the rising prevalence of NAFLD in the general population, we sought to identify its prevalence and potential impact in volunteers for clinical trials. We conducted a cross-sectional study of subjects who were classified as healthy volunteers between 2011 and 2015 and had no known liver disease. Subjects were classified as presumed NAFLD (pNF; alanine aminotransferase [ALT] level ≥ 20 for women or ≥ 31 for men and body mass index [BMI] > 25 kg/m(2) ), healthy non-NAFLD controls (normal ALT and BMI), or indeterminate...
September 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28466261/endoscopic-localization-of-colon-cancer-is-frequently-inaccurate
#19
Jennifer Nayor, Stephen R Rotman, Walter W Chan, Joel E Goldberg, John R Saltzman
BACKGROUND: Colonoscopic location of a tumor can influence both the surgical procedure choice and overall treatment strategy. AIMS: To determine the accuracy of colonoscopy in determining the location of colon cancer compared to surgical localization and to elucidate factors that predict discordant colon cancer localization. METHODS: We conducted a retrospective cross-sectional study of colon cancers diagnosed on colonoscopy at two academic tertiary-care hospitals and two affiliated community hospitals from 2012 to 2014...
August 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28405605/three-dimensional-self-navigated-t2-mapping-for-the-detection-of-acute-cellular-rejection-after-orthotopic-heart-transplantation
#20
Ruud B van Heeswijk, Davide Piccini, Piergiorgio Tozzi, Samuel Rotman, Philippe Meyer, Juerg Schwitter, Matthias Stuber, Roger Hullin
BACKGROUND: T2 mapping is a magnetic resonance imaging technique measuring T2 relaxation time, which increases with the myocardial tissue water content. Myocardial edema is a component of acute cellular rejection (ACR) after heart transplantation. This pilot study compares in heart transplantation recipients a novel high resolution 3-dimensional (3D) T2-mapping technique with standard 2-dimensional (2D) T2-mapping for ACR detection. METHODS: Consecutive asymptomatic patients (n = 26) underwent both 3D T2 mapping and reference 2D T2 mapping magnetic resonance imaging on the day of endomyocardial biopsy (EMB)...
April 2017: Transplantation Direct
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