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https://www.readbyqxmd.com/read/29760622/skin-and-mucous-membranes-manifestations-of-dermatological-diseases-within-the-genital-area-in-females
#1
Katarzyna Plagens-Rotman, Renata Przybylska, Zygmunt Adamski, Magdalena Czarnecka-Operacz
Introduction: Lichen sclerosus et atrophicus (LSA) and an inversed type of psoriasis belong to a group of benign dermatoses usually located within the region of female external genitalia. The most common subjective symptoms reported by patients are itching, pain and changes in the color and structure of the skin. Aim: This paper presents 3 cases of patients suffering from selected dermatoses located within the external female genitalia treated at the Department of Dermatology, Poznan University of Medical Sciences...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29626685/discrepancy-between-neurosurgery-morbidity-and-mortality-conference-discussions-and-hospital-quality-metric-standards
#2
Lauren E Rotman, Matthew C Davis, Arsalaan A Salehani, Devin R Broadwater, Nathaniel H Reeve, Kristen O Riley
OBJECTIVE: Medical institutions use quality metrics to track complications seen in hospital admissions. Similarly, morbidity and mortality (M&M) conferences are held to peer review complications. The purpose of this study was to compare the complications identified in a cohort of patients within 30 days of neurosurgical intervention with those captured in a cohort of M&M conferences. METHODS: All complications that occurred within 30 days of surgery were obtained for patients admitted to the neurosurgical service between May and September 2013...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29603732/freewat-a-free-and-open-source-gis-integrated-hydrological-modeling-platform
#3
Laura Foglia, Iacopo Borsi, Steffen Mehl, Giovanna De Filippis, Massimiliano Cannata, Enric Vasquez-Suñe, Rotman Criollo, Rudy Rossetto
No abstract text is available yet for this article.
March 31, 2018: Ground Water
https://www.readbyqxmd.com/read/29581540/lower-serum-calcium-is-independently-associated-with-ckd-progression
#4
Cynthia J Janmaat, Merel van Diepen, Alessandro Gasparini, Marie Evans, Abdul Rashid Qureshi, Johan Ärnlöv, Peter Barany, Carl-Gustaf Elinder, Joris I Rotmans, Marc Vervloet, Friedo W Dekker, Juan Jesus Carrero
Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at cohort entry, we investigated the association between baseline serum calcium and the subsequent change in estimated glomerular filtration rate (eGFR, by CKD-EPI) decline using linear mixed models...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29575880/modifiable-lifestyle-factors-and-ovarian-cancer-incidence-in-women
#5
Katarzyna Plagens-Rotman, Karolina Chmaj-Wierzchowska, Beata Pięta, Iwona Bojar
INTRODUCTION: A correct diet plays an important role in the prevention of malignant tumours. The risk of the disease may be reduced by introducing a number of changes to the daily diet. The most important changes concern the amount of fat in the diet, dietary fibre, antioxidants in the food and the reduction of substances having a significant impact on the development of malignant tumours. OBJECTIVE: The aim of the study is to analyse the role of selected modifiable lifestyle factors affecting the development of ovarian cancer...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29534843/left-ventricular-mechanical-dispersion-and-global-longitudinal-strain-and-ventricular-arrhythmias-in-predialysis-and-dialysis-patients
#6
Liselotte C R Hensen, Kathleen Goossens, Tomaz Podlesnikar, Joris I Rotmans, J Wouter Jukema, Victoria Delgado, Jeroen J Bax
BACKGROUND: Patients with advanced chronic kidney disease (CKD) have high risk for sudden cardiac death (SCD) and may benefit from implantable cardioverter-defibrillators (ICDs). However, the risk for ICD-related complications is also high in this population. Therefore, there is an unmet need for accurate risk stratification tools to identify patients with CKD at risk for ventricular arrhythmias (VAs), who may benefit from ICD implantation. The aim of this hypothesis-generating study was to investigate the association between left ventricular (LV) mechanical dispersion and LV global longitudinal strain (GLS) measured using two-dimensional speckle-tracking echocardiography and VA and SCD in patients with CKD...
March 10, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29521880/acute-antibody-mediated-rejection-one-week-after-lung-transplantation-successfully-treated-with-eculizumab-intravenous-immunoglobulins-and-rituximab
#7
Yannick D Muller, John-David Aubert, Julien Vionnet, Samuel Rotman, Salima Sadallah, Vincent Aubert, Manuel Pascual
No abstract text is available yet for this article.
March 8, 2018: Transplantation
https://www.readbyqxmd.com/read/29512305/financial-impact-and-effect-on-the-outcome-of-preoperative-tests-for-at-risk-older-hip-fracture-patients
#8
Ely L Steinberg, Yaniv Warschawski, Jacob Elis, Dani Rotman, Gil Rachevsky, Shai Factor, Moshe Salai, Tomer Ben-Tov
AIM: Older patients with proximal femoral fractures often undergo preoperative tests due to coexisting morbidities. Our aim was to evaluate these tests and their impact on patient outcome and medical expenses. METHODS: This retrospective study includes data on head computed tomography, carotid ultrasound, echocardiography and pulmonary functional tests calculated according to the type of surgery (osteosynthesis or hip arthroplasty) carried out on 2798 patients. Time-to-surgery, test repeated postoperatively, American Society of Anesthesiology Physical Status score, additional procedures, hospitalization time, 30-day mortality and associated medical expenses were evaluated...
March 7, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29510276/intracranial-hemorrhage-in-patients-with-a-left-ventricular-assist-device
#9
MULTICENTER STUDY
Rizwan A Tahir, Lauren E Rotman, Matthew C Davis, Esther B Dupépé, Maximillian K Kole, Mahnaz Rehman, Celeste T Williams, Salpy V Pamboukian, Michael Bazydlo, Beverly C Walters
BACKGROUND: There is a dearth of literature regarding management and outcomes of patients with a left ventricular assist device (LVAD) for advanced heart failure who develop intracranial hemorrhage (ICH). We conducted a case series from 2 centers highlighting patient outcomes and prognostic factors to help clinicians better understand and care for these high-risk patients. METHODS: A case series from 2 large-volume institutions (defined as large by the Nationwide Inpatient Sample hospital size, i...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29459042/churg-strauss-syndrome-with-cardiac-involvement-case-illustration-and-contribution-of-cmr-in-the-diagnosis-and-clinical-follow-up
#10
E d'Ersu, C Ribi, P Monney, G Vincenti, J Schwitter, S Rotman, R Hullin, J Regamey
This report summarises three cases of Churg-Strauss syndrome (CSS) illustrating the diagnostic challenges associated with the cardiac manifestation of this disease. Here, we illustrate the role of cardiac magnetic resonance (CMR) for diagnosis and follow-up of CSS with a focus on new non-contrast T2 -weighted imaging sequences for quantification of myocardial scar tissue and quantitative T2 mapping techniques, which allow the detection of myocardial edema.
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29431694/ildr2-is-a-novel-b7-like-protein-that-negatively-regulates-t-cell-responses
#11
Iris Hecht, Amir Toporik, Joseph R Podojil, Ilan Vaknin, Gady Cojocaru, Anat Oren, Elizabeta Aizman, Spencer C Liang, Ling Leung, Yosef Dicken, Amit Novik, Nadav Marbach-Bar, Aziza Elmesmari, Clare Tange, Ashley Gilmour, Donna McIntyre, Mariola Kurowska-Stolarska, Kay McNamee, Judith Leitner, Shirley Greenwald, Liat Dassa, Zurit Levine, Peter Steinberger, Richard O Williams, Stephen D Miller, Iain B McInnes, Eyal Neria, Galit Rotman
The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies for human diseases. We identified Ig-like domain-containing receptor (ILDR)2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells...
March 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29431690/ildr2-fc-is-a-novel-regulator-of-immune-homeostasis-and-inducer-of-antigen-specific-immune-tolerance
#12
Joseph R Podojil, Iris Hecht, Ming-Yi Chiang, Ilan Vaknin, Inbal Barbiro, Amit Novik, Eyal Neria, Galit Rotman, Stephen D Miller
ILDR2 is a member of the Ig superfamily, which is implicated in tricellular tight junctions, and has a putative role in pancreatic islet health and survival. We recently found a novel role for ILDR2 in delivering inhibitory signals to T cells. In this article, we show that short-term treatment with ILDR2-Fc results in long-term durable beneficial effects in the relapsing-remitting experimental autoimmune encephalomyelitis and NOD type 1 diabetes models. ILDR2-Fc also promotes transplant engraftment in a minor mismatch bone marrow transplantation model...
March 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29396698/vertebral-fractures-following-denosumab-discontinuation-in-patients-with-prolonged-exposure-to-bisphosphonates
#13
Liana Tripto-Shkolnik, Vanessa Rouach, Yonit Marcus, Pnina Rotman-Pikielny, Carlos Benbassat, Iris Vered
Denosumab (DMAB) efficacy for treatment of osteoporosis was demonstrated in a pivotal trial with a reduction in vertebral and hip fractures during 3 years, and fracture risk reduction was sustained up to 10 years in an extension study. DMAB causes potent yet reversible inhibition of bone resorption. Bone density declines rapidly upon discontinuation and bone turnover markers increase above baseline in a rebound fashion. Spontaneous multiple vertebral fractures after DMAB discontinuation were recently reported...
February 2, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29355796/clinical-utility-of-serum-procalcitonin-level-and-infection-in-the-neurosurgical-intensive-care-unit
#14
Lauren E Rotman, Bonita S Agee, Gustavo Chagoya, Matthew C Davis, James M Markert
BACKGROUND: Procalcitonin, a bloodstream inflammatory biomarker, has proven useful in the diagnosis of sepsis in critically ill patients treated in medical and surgical intensive care units. This study aims to further our understanding of the significance of procalcitonin levels in neuroscience intensive care unit (NICU) patients. METHODS: Neurosurgical patients who underwent a procalcitonin assay in an NICU over a 2-year period were included in our analysis. A procalcitonin level ≥0...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29337301/hepatic-gi-signaling-regulates-whole-body-glucose-homeostasis
#15
Mario Rossi, Lu Zhu, Sara M McMillin, Sai Prasad Pydi, Shanu Jain, Lei Wang, Yinghong Cui, Regina J Lee, Amanda H Cohen, Hideaki Kaneto, Morris J Birnbaum, Yanling Ma, Yaron Rotman, Jie Liu, Travis J Cyphert, Toren Finkel, Owen P McGuinness, Jürgen Wess
An increase in hepatic glucose production (HGP) is a key feature of type 2 diabetes. Excessive signaling through hepatic Gs-linked glucagon receptors critically contributes to pathologically elevated HGP. Here, we tested the hypothesis that this metabolic impairment can be counteracted by enhancing hepatic Gi signaling. Specifically, we used a chemogenetic approach to selectively activate Gi-type G proteins in mouse hepatocytes in vivo. Unexpectedly, activation of hepatic Gi signaling triggered a pronounced increase in HGP and severely impaired glucose homeostasis...
February 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29301522/the-low-indexes-of-metabolism-intervention-trial-limit-design-and-baseline-data-of-a-randomized-controlled-clinical-trial-to-evaluate-how-alerting-primary-care-teams-to-low-metabolic-values-could-affect-the-health-of-patients-aged-75-or-older
#16
Nir Tsabar, Yan Press, Johanna Rotman, Bracha Klein, Yonatan Grossman, Maya Vainshtein-Tal, Sophia Eilat-Tsanani
BACKGROUND: Too-low body mass index (BMI), HbA1c% or cholesterol levels predicts poor survival. This study investigates whether e-mails about these low values, improve health of people older than 75 years. METHODS: LIMIT - an open label randomized trial - compares usual care to the addition of an e-mail which alerts the family physicians and nurses to low metabolic indexes of a specific patient and advises on nutritional and medical changes. PARTICIPANTS: Clalit Health Services (CHS) patients in the Northern and Southern Districts, aged ≥75 years with any of the following inclusion criteria: a...
January 5, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29238566/water-level-affects-availability-of-optimal-feeding-habitats-for-threatened-migratory-waterbirds
#17
Yaara Aharon-Rotman, John McEvoy, Zheng Zhaoju, Hui Yu, Xin Wang, Yali Si, Zhenggang Xu, Zeng Yuan, Wooseog Jeong, Lei Cao, Anthony D Fox
Extensive ephemeral wetlands at Poyang Lake, created by dramatic seasonal changes in water level, constitute the main wintering site for migratory Anatidae in China. Reductions in wetland area during the last 15 years have led to proposals to build a Poyang Dam to retain high winter water levels within the lake. Changing the natural hydrological system will affect waterbirds dependent on water level changes for food availability and accessibility. We tracked two goose species with different feeding behaviors (greater white-fronted geese Anser albifrons [grazing species] and swan geese Anser cygnoides [tuber-feeding species]) during two winters with contrasting water levels (continuous recession in 2015; sustained high water in 2016, similar to those predicted post-Poyang Dam), investigating the effects of water level change on their habitat selection based on vegetation and elevation...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29204528/serum-testosterone-changes-in-patients-treated-with-radiation-therapy-alone-for-prostate-cancer-on-nrg-oncology-rtog-9408
#18
R Charles Nichols, Chen Hu, Jean-Paul Bahary, Kenneth L Zeitzer, Luis Souhami, Mark H Leibenhaut, Marvin Rotman, Elizabeth M Gore, Alexander G Balogh, David McGowan, Jeff Michalski, Adam Raben, Shari Rudoler, Christopher U Jones, Howard Sandler
Objectives: We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408. Methods and materials: Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 months after RT. The Wilcoxon signed rank test was used to compare pre- and post-treatment ST levels in patients who were randomized to the RT-alone arm...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29188313/arteriovenous-fistula-maturation-failure-in-a-large-cohort-of-hemodialysis-patients-in-the-netherlands
#19
Bram M Voorzaat, Koen E A van der Bogt, Cynthia J Janmaat, Jan van Schaik, Friedo W Dekker, Joris I Rotmans
OBJECTIVES: Radiocephalic arteriovenous fistulas (RCAVF) are the preferred vascular access (VA) for hemodialysis (HD). Cohort studies from North America revealed that nonmaturation is a significant disadvantage of RCAVFs compared to other VAs. DESIGN: This present retrospective study describes the incidence of nonmaturation of AVFs and functional failure of arteriovenous grafts (AVG) in a multicentre cohort in the Netherlands and attempts to create a prediction model for nonmaturation of RCAVFs...
November 29, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29164753/prevalence-of-left-ventricular-systolic-dysfunction-in-pre-dialysis-and-dialysis-patients-with-preserved-left-ventricular-ejection-fraction
#20
Liselotte C R Hensen, Kathleen Goossens, Victoria Delgado, Rachid Abou, Joris I Rotmans, J Wouter Jukema, Jeroen J Bax
AIMS: Patients with chronic kidney disease (CKD) have an excess of cardiovascular morbidity and mortality, with heart failure (HF) being particularly frequent. Reduced left ventricular ejection fraction (LVEF) defines left ventricular (LV) systolic dysfunction and is associated with poor prognosis. However, CKD patients may have HF symptoms with preserved LVEF. In this subgroup of patients, two-dimensional speckle tracking echocardiography can detect LV systolic dysfunction by analysing LV myocardial deformation...
November 21, 2017: European Journal of Heart Failure
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