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William C Scott, Christopher K Giardina, Andrew K Pappa, Tatyana E Fontenot, Meredith L Anderson, Margaret T Dillon, Kevin D Brown, Harold C Pillsbury, Oliver F Adunka, Craig A Buchman, Douglas C Fitzpatrick
HYPOTHESIS: The compound action potential (CAP) is a purely neural component of the cochlea's response to sound, and may provide information regarding the existing neural substrate in cochlear implant (CI) subjects that can help account for variance in speech perception outcomes. BACKGROUND: Measurement of the "total response" (TR), or sum of the magnitudes of spectral components in the ongoing responses to tone bursts across frequencies, has been shown to account for 40 to 50% of variance in speech perception outcomes...
October 4, 2016: Otology & Neurotology
Jeremy Hornibrook, Philip Bird, Edward Flook, Greg A O'Beirne
No abstract text is available yet for this article.
September 16, 2016: Otology & Neurotology
Fuat Ziylan, Diederik P J Smeeing, Inge Stegeman, Hans G X M Thomeer
No abstract text is available yet for this article.
September 16, 2016: Otology & Neurotology
M Charles Liberman, Michael J Epstein, Sandra S Cleveland, Haobing Wang, Stéphane F Maison
Recent work suggests that hair cells are not the most vulnerable elements in the inner ear; rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate first in the aging or noise-exposed ear. This primary neural degeneration does not affect hearing thresholds, but likely contributes to problems understanding speech in difficult listening environments, and may be important in the generation of tinnitus and/or hyperacusis. To look for signs of cochlear synaptopathy in humans, we recruited college students and divided them into low-risk and high-risk groups based on self-report of noise exposure and use of hearing protection...
2016: PloS One
W Shehata-Dieler, W Großmann
The primary diagnostic aim prior to cochlear implantation is establishment of a comprehensive and multidisciplinary diagnosis, in order to subsequently begin therapy as early as possible. Audiological evaluation prior to implantation employs a test battery-approach, including subjective and objective procedures. Objective measures show high reliability and therefore play a major role in the diagnosis of difficult-to-test subjects such as infants and young children. During postoperative follow-up, objective measures offer a valid method for analyzing the effects of different stimuli on the auditory system...
August 10, 2016: HNO
Dayong Wang, Binbin Xiong, Fen Xiong, Guang-Di Chen, Bo Hua Hu, Wei Sun
CONCLUSION: This study indicates that the lesion of hair cells in the apical turn of the cochlea can cause the change in the summating potential (SP)/Compound potential (CAP) ratio. OBJECTIVES: Electrocochleography is a valuable clinic test for diagnosis of cochlear pathologies and the ratio of SP to CAP has been used to identify Meniere's disease. However, it remains controversial whether the increase of the SP/CAP ratio represents exclusively the endolymphatic hydrops...
July 18, 2016: Acta Oto-laryngologica
Pauliana Lamounier, Thiago Silva Almeida de Souza, Debora Aparecida Gobbo, Fayez Bahmad
INTRODUCTION: Ménière's disease (MD) is an inner ear disorder characterized by episodic vertigo, tinnitus, ear fullness, and fluctuating hearing. Its diagnosis can be especially difficult in cases where vestibular symptoms are present in isolation (vestibular MD). The definitive diagnosis is made histologically and can only be performed post-mortem, after analysis of the temporal bone. Endolymphatic hydrops is a histopathological finding of the disease and occurs more often in the cochlea and saccule, followed by the utricle and semicircular canals...
June 2, 2016: Brazilian Journal of Otorhinolaryngology
Umur Yollu, Derya Ugurlu Uluduz, Mehmet Yilmaz, H Murat Yener, Ferit Akil, Burcu Kuzu, Eyyup Kara, Duygu Hayir, Didem Ceylan, Nazim Korkut
OBJECTIVE: The primary aim of this study is to do a vestibular migraine scan in a population of patients with migraine diagnosis using the most recent standardized diagnosis criterion which is International Classification of Headache Disorders (ICHD) 3 Beta and to identify the epidemiological data. The second part of the study involves performing several vestibulocochlear tests on patients who received vestibular migraine (VM) diagnosis to collect data that may be important for diagnostic purposes by comparing the patients with normal population when necessary...
July 6, 2016: Clinical Otolaryngology
Jong Dae Lee, Hyun Ji Kim, Jinsei Jung, Sung Huhn Kim, Bo Gyung Kim, Kyu-Sung Kim
CONCLUSION: The dehydration test using isosorbide is well tolerated when used to detect endolymphatic hydrops and may also be used to improve the sensitivity of ECoG performed on patients with MD, especially in poor hearing at low-frequency. OBJECTIVE: This prospective study was to explore the diagnostic utility of a dehydration test, administering oral isosorbide, which has been used to treat Meniere's disease (MD). METHOD: Electrocochleography (ECoG) and the dehydration test with isosorbide were performed on 32 patients diagnosed with definite diagnosed MD...
June 27, 2016: Acta Oto-laryngologica
P Trevisi, A Ciorba, C Aimoni, R Bovo, A Martini
The aim of this paper is to assess the long-term audiological features and outcomes of hearing rehabilitation in a large group of individuals with CHARGE Syndrome. The study has been conducted retrospectively, on a paediatric patient database, at the Audiology Department of the University Hospitals of Ferrara and Padua. The study sample included 31 children presenting with different degrees of hearing impairment associated with CHARGE syndrome. Hearing was assessed using auditory brainstem responses (ABRs) and/or electrocochleography, or conditioned audiometry (visual reinforcement audiometry [VRA] or play audiometry)...
June 2016: Acta Otorhinolaryngologica Italica
Tsutomu Nakashima, Ilmari Pyykkö, Megan A Arroll, Margaretha L Casselbrant, Carol A Foster, Nauman F Manzoor, Cliff A Megerian, Shinji Naganawa, Yi-Ho Young
Meniere's disease (MD) is a disorder of the inner ear that causes vertigo attacks, fluctuating hearing loss, tinnitus and aural fullness. The aetiology of MD is multifactorial. A characteristic sign of MD is endolymphatic hydrops (EH), a disorder in which excessive endolymph accumulates in the inner ear and causes damage to the ganglion cells. In most patients, the clinical symptoms of MD present after considerable accumulation of endolymph has occurred. However, some patients develop symptoms in the early stages of EH...
2016: Nature Reviews. Disease Primers
Francisco Fernández-Cervilla, María Martínez-Martínez, Eduardo Fernández-Segura, Francisco Javier Cañizares-García, Pascual Vicente Crespo-Ferrer
The aim of this study was to use functional and morphological analyses to evaluate the protective effect of coenzyme A (CoA) in cisplatin-induced toxicity in outer hair cells (OHC). Three groups of 8 guinea pigs were used: control (group I), cisplatin-treated (group II) and cisplatin + CoA-treated (group III). In groups II and III, a single ototoxic dose of cisplatin (10 mg/kg) was injected intraperitoneally. Group III was co-treated with CoA (900 μg/kg per day for 7 consecutive days). Electrocochleography (ECoG) recordings were made before and after the 7-day treatment period in all groups...
April 28, 2016: Histology and Histopathology
Fuat Ziylan, Diederik P J Smeeing, Inge Stegeman, Hans G X M Thomeer
OBJECTIVE: To evaluate the diagnostic value of electrocochleography compared with magnetic resonance imaging (MRI) with intratympanic gadolinium administration to diagnose endolymphatic hydrops in patients with Ménière's disease. DATA SOURCES: An electronic search was performed in the PubMed, EMBASE, and Cochrane databases on September 15, 2015. A systematic search was conducted. Articles were included if written in English, Dutch, German, or French language. STUDY SELECTION: Original studies reporting on the diagnostic value of electrocochleography compared with MRI with intratympanic gadolinium administration, were included...
June 2016: Otology & Neurotology
Jaume Redondo-Martínez, Antonio Morant-Ventura, Diana Robledo-Aguayo, Alejandra Ayas-Montero, Elvira Mencheta-Benet, Jaime Marco-Algarra
INTRODUCTION AND OBJECTIVES: Extra-tympanic electrocochleography is an electrophysiological register obtained after stimulating the cochlea with an audible stimulus. This stimulus is applied using an earphone over the external auditory canal, while the electrical activity is registered by surface electrodes. There are few studies that analyse normal electrocochleography in our environment. Thus, the main objective of our study was to regularize the values obtained with electrocochleography in ears without any otoneurological diseases...
September 2016: Acta Otorrinolaringológica Española
Gi Jung Im, Sung Kyun Kim, June Choi, Jae Jun Song, Sung Won Chae, Hak Hyun Jung
Conclusion This study demonstrated excellent hearing recovery following the combined treatment of diuretic and oral steroid, and electrocochleography (ECoG) was significantly higher than normal side. This study reports characteristics of acute low-tone hearing loss (ALHL) that show the greater low-tone hearing loss, the higher ECoG, and excellent recovery, even-though low-tone hearing loss is worse, which can be different compared with sudden deafness. Objective To analyze ALHL without vertigo, this study compared the ALHL group with all patients exhibiting low-tone hearing loss and ear fullness...
July 2016: Acta Oto-laryngologica
Adrian Dalbert, Alexander Huber, Dorothe Veraguth, Christof Roosli, Flurin Pfiffner
OBJECTIVE: To assess cochlear trauma during cochlear implantation by electrocochleography (ECoG) and cone beam computed tomography (CBCT) and to correlate intraoperative cochlear trauma with postoperative loss of residual hearing. METHODS: ECoG recordings to tone bursts at 250, 500, 750, and 1000 Hz and click stimuli were recorded before and after insertion of the cochlear implant electrode array, using an extracochlear recording electrode. CBCTs were conducted within 6 weeks after surgery...
June 2016: Otology & Neurotology
Chathura Lahiru Kumaragamage, Brian John Lithgow, Zahra Kazem Moussavi
GOAL: The aim of this study was to investigate methods to improve signal-to-noise ratio (SNR) of extratympanic electrocochleography (ET-ECOG); a low SNR electrophysiological measurement technique. The current standard for ET-ECOG involves acquiring and uniform averaging ∼1000 evoked responses to reveal the signal of interest. Weighted averaging is commonly employed to enhance SNR of repetitive signals in the presence of a nonstationary noise, yet its efficacy in ET-ECOG has not been explored to date, which was the focus of this study...
February 2016: IEEE Transactions on Bio-medical Engineering
Christopher D Brook, Karen Buch, Matthew Kaufmann, Osamu Sakai, Anand K Devaiah
Background To determine the prevalence of a high-riding jugular bulb (HRJB) in the endolymphatic hydrops population. Methods This was a retrospective chart and radiology review of patients seen at a tertiary care medical center. Patients were identified using the International Classification of Diseases, 9th edition, code 386.xx (Meniere disease-unspecified), and were required to have undergone an imaging study that included views of the jugular bulb that were available for review. A radiologist then evaluated all of the imaging studies for evidence of HRJB or inner ear dehiscence with a jugular bulb abnormality...
December 2015: Journal of Neurological Surgery. Part B, Skull Base
Carlos Minaya, Samuel R Atcherson
The purpose of this study was to revisit the two-channel, simultaneous click-evoked extratympanic electrocochleography and auditory brainstem response (ECoG/ABR) recording technique for clinical use in normal hearing participants. Recording the compound action potential (AP) of the ECoG simultaneously with ABR may be useful when Wave I of the ABR is small or diminished in patients with sensorineural or retrocochlear disorder and minimizes overall test time. In contrast to some previous studies that used the extratympanic electrode both as non-inverting electrode for the ECoG and inverting electrode for ABR, this study maintained separate recording channel montages unique to conventional click-evoked ECoG and ABR recordings...
January 21, 2015: Audiology Research
Abdullah Dalgıç, Oğuz Yılmaz, Yusuf Hıdır, Bülent Satar, Mustafa Gerek
OBJECTIVE: Our objective was to analyze the electrocochleography (ECoG) and cervical vestibular evoked myogenic potential (cVEMP) results of patients with noise-induced hearing loss (NIHL). MATERIALS AND METHODS: The study included 20 patients with NIHL. Pure-tone audiometry, tympanic membrane ECoG, and cVEMP were performed on all patients. The patients were divided into two groups based on averaged thresholds at 4, 6, and 8 kHz; whereby, group 1 comprised patients who had a threshold higher than 68...
August 2015: Journal of International Advanced Otology
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