keyword
MENU ▼
Read by QxMD icon Read
search

Hair cells

keyword
https://www.readbyqxmd.com/read/28922768/accerbatin-a-small-molecule-at-the-intersection-of-auxin-and-reactive-oxygen-species-homeostasis-with-herbicidal-properties
#1
Yuming Hu, Thomas Depaepe, Dajo Smet, Klara Hoyerova, Petr Klíma, Ann Cuypers, Sean Cutler, Dieter Buyst, Kris Morreel, Wout Boerjan, José Martins, Jan Petrášek, Filip Vandenbussche, Dominique Van Der Straeten
The volatile two-carbon hormone ethylene acts in concert with an array of signals to affect etiolated seedling development. From a chemical screen, we isolated a quinoline carboxamide designated ACCERBATIN (AEX) that exacerbates the 1-aminocyclopropane-1-carboxylic acid-induced triple response, typical for ethylene-treated seedlings in darkness. Phenotypic analyses revealed distinct AEX effects including inhibition of root hair development and shortening of the root meristem. Mutant analysis and reporter studies further suggested that AEX most probably acts in parallel to ethylene signaling...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28922518/accelerated-epithelialization-and-improved-wound-healing-metrics-in-porcine-full-thickness-wounds-transplanted-with-full-thickness-skin-micrografts
#2
Christina L Rettinger, John L Fletcher, Anders H Carlsson, Rodney K Chan
Split-thickness skin grafting (STSG) is the current gold standard for treatment of extensive burn and traumatic skin injuries. However, STSG is limited by donor-site morbidity and availability, and often leads to scarring and wound contracture. Furthermore, these thin grafts lack dermal elements such as nerves and adnexa which are important in recapitulating normal skin function. Methods of fractional skin replacement either as minced STSGs or microscopic skin tissue columns (MSTCs) have been proposed, though these techniques have not been fully-characterized and lack evidence of regenerated adnexal structures...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28918952/a-dual-function-for-prickle-in-regulating-frizzled-stability-during-feedback-dependent-amplification-of-planar-polarity
#3
Samantha J Warrington, Helen Strutt, Katherine H Fisher, David Strutt
The core planar polarity pathway coordinates epithelial cell polarity during animal development, and loss of its activity gives rise to a range of defects, from aberrant morphogenetic cell movements to failure to correctly orient structures, such as hairs and cilia. The core pathway functions via a mechanism involving segregation of its protein components to opposite cells ends, where they form asymmetric intracellular complexes that couple cell-cell polarity. This segregation is a self-organizing process driven by feedback interactions between the core proteins themselves...
September 7, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28917852/bio-responsive-alginate-keratin-composite-nanogels-with-enhanced-drug-loading-efficiency-for-cancer-therapy
#4
Zhe Sun, Zeng Yi, Huaiying Zhang, Xiaomin Ma, Wen Su, Xiaoyu Sun, Xudong Li
This article presents a novel dual-stimuli responsive nanogel prepared from human hair keratin and alginate through simple crosslinking method. Keratin offer the crosslinking structure and bio-responsive ability and alginate ameliorated properties of nanogels including particle size, stability and drug loading capacity. The resultant keratin-alginate nanogels (KSA-NGs) could function as promising vectors for doxorubicin hydrochloride (DOX) with a super-high drug-loading rate of 52.9% (w/w) and dual-stimuli responsive behavior to GSH and trypsin...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28916740/mad2b-acts-as-a-negative-regulatory-partner-of-tcf4-on-proliferation-in-human-dermal-papilla-cells
#5
Nanlan Yu, Zhiqiang Song, Kezhou Zhang, Xichuan Yang
Dermal papilla cells (DPCs) are important components of hair follicles and play a critical role in hair follicle development. However, the mechanisms by which DPCs induce hair follicle development remain unclear. In the present study, we identified the mitotic arrest deficient protein MAD2B as a modifier of DPCs. Overexpression of MAD2B inhibited DPC aggregative growth and proliferation induced by the Wnt signaling activator T cell factor 4 (TCF4), and decreased TCF4-induced expression and the release of hair growth-related cytokines, including hepatocyte growth factor, insulin-like growth factor-1, and vascular endothelial growth factor in DPCs...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915323/hair-cell-transduction-tuning-and-synaptic-transmission-in-the-mammalian-cochlea
#6
Robert Fettiplace
Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear. Recordings of hair cell electrical responses have shown that they transduce sound via submicrometer deflections of their hair bundles, which are arrays of interconnected stereocilia containing the mechanoelectrical transducer (MET) channels. MET channels are activated by tension in extracellular tip links bridging adjacent stereocilia, and they can respond within microseconds to nanometer displacements of the bundle, facilitated by multiple processes of Ca2+-dependent adaptation...
September 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28914451/pilomatrix-carcinoma-a-10-year-review-of-the-literature
#7
REVIEW
Christopher Jones, Mark Twoon, Weiguang Ho, Mark Portelli, Bernard Robertson, William Anderson
Pilomatrixoma, also known as calcifying epithelioma of Malherbe, is a superficial benign skin tumour arising from hair follicle matrix cells (1,2) usually located in the head or neck region (1). It was first described in 1880 by Malherbe and Chenantais as a calcified epithelioma of sebaceous origin. In 1961, Forbis and Helwig proposed the term pilomatrixoma after establishing that the lesion actually originated from the outer root sheath cell of hair follicles (3-5).
September 15, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28913895/nramp2-a-trans-golgi-network-localized-manganese-transporter-is-required-for-arabidopsis-root-growth-under-manganese-deficiency
#8
Huiling Gao, Wenxiang Xie, Changhong Yang, Jingyi Xu, Jingjun Li, Hua Wang, Xi Chen, Chao-Feng Huang
To cope with manganese (Mn) deficiency, plants have evolved an efficient transport system to uptake and redistribute Mn. However, the underlying molecular mechanisms remain to be demonstrated. We carried out a forward genetic screen in a root high-affinity Mn transporter nramp1 mutant background in Arabidopsis thaliana and identified an uncharacterized Mn transport NRAMP2. We investigated the effect of nramp2 mutation on root growth and reactive oxygen species (ROS) accumulation and we also examined the NRAMP2 expression pattern, and the subcellular localization and transport activity of NRAMP2...
September 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/28912581/secretory-phospholipase-a2-iia-overexpressing-mice-exhibit-cyclic-alopecia-mediated-through-aberrant-hair-shaft-differentiation-and-impaired-wound-healing-response
#9
Gopal L Chovatiya, Rahul M Sarate, Raghava R Sunkara, Nilesh P Gawas, Vineet Kala, Sanjeev K Waghmare
Secretory phospholipase A2 Group-IIA (sPLA2-IIA) is involved in lipid catabolism and growth promoting activity. sPLA2-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA2-IIA in the development of cyclic alopecia and wound healing response in relation to complete loss of hair follicle stem cells (HFSCs). Our data showed that overexpression of sPLA2-IIA in homozygous mice results in hyperproliferation and terminal epidermal differentiation followed by hair follicle cycle being halted at anagen like stage...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912032/androgens-and-androgen-receptor-action-in-skin-and-hair-follicles
#10
REVIEW
Julieta María Ceruti, Gustavo José Leirós, María Eugenia Balañá
Beyond sexual functions, androgens exert their action in skin physiology and pathophysiology. Skin cells are able to synthesize most of active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we go over recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of its molecular mechanisms in androgenetic alopecia (AGA)...
September 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28911317/generation-of-ips-derived-model-cells-for-analyses-of-hair-shaft-differentiation
#11
Takumi Kido, Tomoatsu Horigome, Minori Uda, Naoki Adachi, Yohei Hirai
Biological evaluation of hair growth/differentiation activity in vitro has been a formidable challenge, primarily due to the lack of relevant model cell systems. To solve this problem, we generated a stable model cell line in which successive differentiation via epidermal progenitors to hair components is easily inducible and traceable. Mouse induced pluripotent stem (iPS) cell-derived cells were selected to stably express a tetracycline (Tet)-inducible bone morphogenic protein-4 (BMP4) expression cassette and a luciferase reporter driven by a hair-specific keratin 31 gene (krt31) promoter (Tet-BMP4-KRT31-Luc iPS)...
September 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28910707/spectral-phasor-analysis-reveals-altered-membrane-order-and-function-of-root-hair-cells-in-arabidopsis-dry2-sqe1-5-drought-hypersensitive-mutant
#12
Florencia Sena, Mariana Sotelo-Silveira, Soledad Astrada, Miguel A Botella, Leonel Malacrida, Omar Borsani
Biological membranes allow the regulation of numerous cellular processes, which are affected when unfavorable environmental factors are perceived. Lipids and proteins are the principal components of biological membranes. Each lipid has unique biophysical properties, and, therefore the lipid composition of the membrane is critical to maintaining the bilayer structure and functionality. Membrane composition and integrity are becoming the focus of studies aiming to understand how plants adapt to its environment...
August 26, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28905175/the-promotion-of-hair-regrowth-by-topical-application-of-a-perilla-frutescens-extract-through-increased-cell-viability-and-antagonism-of-testosterone-and-dihydrotestosterone
#13
Jing-Jie Li, Zheng Li, Li-Juan Gu, Kang-Ju Choi, Dong-Seon Kim, Ho-Kyoung Kim, Chang-Keun Sung
This study investigated the potential hair regrowth effects associated with a plant extract of Perilla frutescens, which was selected due to its putative hair regrowth activity. Extracts were prepared from dried P. frutescens suspended in distilled water, where the resultant aqueous suspension was fractionated sequentially using hexane, ethyl acetate, n-butanol, and distilled water. We observed that the n-butanol fraction resulted in the highest hair regrowth activity. The n-butanol soluble fraction of P. frutescens extract (BFPE) was further separated using AB-8 macroporous resin and silica gel chromatography to obtain rosmarinic acid (RA), which demonstrated effective hair growth regeneration potential...
September 13, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28904763/winter-bait-stations-as-a-multispecies-survey-tool
#14
Lacy Robinson, Samuel A Cushman, Michael K Lucid
Winter bait stations are becoming a commonly used technique for multispecies inventory and monitoring but a technical evaluation of their effectiveness is lacking. Bait stations have three components: carcass attractant, remote camera, and hair snare. Our 22,975 km(2) mountainous study area was stratified with a 5 × 5 km sampling grid centered on northern Idaho and including portions of Washington, Montana, and British Columbia. From 2010-14, we conducted 563 sampling sessions at 497 bait stations in 453 5 × 5 km cells...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28904532/the-use-of-adipose-derived-stem-cells-in-selected-skin-diseases-vitiligo-alopecia-and-nonhealing-wounds
#15
REVIEW
Agnieszka Owczarczyk-Saczonek, Anna Wociór, Waldemar Placek, Wojciech Maksymowicz, Joanna Wojtkiewicz
The promising results derived from the use of adipose-derived stem cells (ADSCs) in many diseases are a subject of observation in preclinical studies. ADSCs seem to be the ideal cell population for the use in regenerative medicine due to their easy isolation, nonimmunogenic properties, multipotential nature, possibilities for differentiation into various cell lines, and potential for angiogenesis. This article reviews the current data on the use of ADSCs in the treatment of vitiligo, various types of hair loss, and the healing of chronic wounds...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28903047/caloric-restriction-promotes-structural-and-metabolic-changes-in-the-skin
#16
Maria Fernanda Forni, Julia Peloggia, Tárcio T Braga, Jesús Eduardo Ortega Chinchilla, Jorge Shinohara, Carlos Arturo Navas, Niels Olsen Saraiva Camara, Alicia J Kowaltowski
Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its effect on the skin is poorly understood. Here, we show that CR mice display fur coat remodeling associated with an expansion of the hair follicle stem cell (HFSC) pool. We also find that the dermal adipocyte depot (dWAT) is underdeveloped in CR animals. The dermal/vennule annulus vasculature is enlarged, and a vascular endothelial growth factor (VEGF) switch and metabolic reprogramming in both the dermis and the epidermis are observed...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28900799/peroxynitrite-induces-apoptosis-of-mouse-cochlear-hair-cells-via-a-caspase-independent-pathway-in-vitro
#17
Zhixin Cao, Qianqian Yang, Haiyan Yin, Qi Qi, Hongrui Li, Gaoying Sun, Hongliang Wang, Wenwen Liu, Jianfeng Li
Peroxynitrite (ONOO(-)) is a potent and versatile oxidant implicated in a number of pathophysiological processes. The present study was designed to investigate the effect of ONOO(-) on the cultured cochlear hair cells (HCs) of C57BL/6 mice in vitro as well as the possible mechanism underlying the action of such an oxidative stress. The in vitro primary cultured cochlear HCs were subjected to different concentrations of ONOO(-), then, the cell survival and morphological changes were examined by immunofluorescence and transmission electron microscopy (TEM), the apoptosis was determined by Terminal deoxynucleotidyl transferase dUNT nick end labeling (TUNEL) assay, the mRNA expressions of Caspase-3, Caspase-8, Caspase-9, Apaf1, Bcl-2, and Bax were analyzed by RT-PCR, and the protein expressions of Caspase-3 and AIF were assessed by immunofluorescence...
September 12, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28899994/heterodimeric-capping-protein-is-required-for-stereocilia-length-and-width-regulation
#18
Matthew R Avenarius, Jocelyn F Krey, Rachel A Dumont, Clive P Morgan, Connor B Benson, Sarath Vijayakumar, Christopher L Cunningham, Deborah I Scheffer, David P Corey, Ulrich Müller, Sherri M Jones, Peter G Barr-Gillespie
Control of the dimensions of actin-rich processes like filopodia, lamellipodia, microvilli, and stereocilia requires the coordinated activity of many proteins. Each of these actin structures relies on heterodimeric capping protein (CAPZ), which blocks actin polymerization at barbed ends. Because dimension control of the inner ear's stereocilia is particularly precise, we studied the CAPZB subunit in hair cells. CAPZB, present at ∼100 copies per stereocilium, concentrated at stereocilia tips as hair cell development progressed, similar to the CAPZB-interacting protein TWF2...
September 12, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28899666/stem-cells-and-the-circadian-clock
#19
REVIEW
Meltem Weger, Nicolas Diotel, Anne-Claire Dorsemans, Thomas Dickmeis, Benjamin D Weger
The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24h rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regulation. Rhythmic oscillations have been observed in a variety of embryonic and adult stem cell dependent processes, such as hematopoietic progenitor cell migration, the hair follicle cycle, bone remodeling, regenerative myogenesis and neurogenesis. This review aims to discuss the nature of the circadian clock in embryonic stem cells and how it changes during differentiation...
September 9, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28899430/the-aberrant-upstream-pathway-regulations-of-cdk1-protein-were-implicated-in-the-proliferation-and-apoptosis-of-ovarian-cancer-cells
#20
Ruitao Zhang, Huirong Shi, Fang Ren, Minghui Zhang, Pengcheng Ji, Wenwen Wang, Chuanna Liu
BACKGROUND: Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship between CDK1 and the proliferation and apoptosis of ovarian cancer cells, investigate its molecular mechanism preliminarily. METHODS: The specific short-hair RNA (shRNA) plasmids and negative control plasmid of CDK1, checkpoint kinase 1 (CHK1) and p53 genes were transfected into ovarian cancer SK-OV-3 and OVCAR-3 cells respectively...
September 12, 2017: Journal of Ovarian Research
keyword
keyword
76090
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"