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https://www.readbyqxmd.com/read/29471003/trkb-receptor-antagonism-inhibits-stab-injury-induced-proliferative-response-in-adult-zebrafish-danio-rerio-brain
#1
Surendra Kumar Anand, Amal Chandra Mondal
The Tropomyosin related kinase (TrkB) receptor, is known to promote neuronal maturation, differentiation, maintenance and survival through its cognate ligands Brain derived neurotrophic factor (BDNF) and neurotrophin 4 (NT4). BDNF, NT4 and TrkB are highly conserved proteins among vertebrates. Although the role of TrkB during brain development is well established, its role in adult neurogenesis and brain regeneration awaits thorough investigation. In this study, we used the zebrafish stab wound injury model to determine whether the injury induced regeneration response in the telencephalon region is governed by TrkB or not...
February 19, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29465848/the-avocado-hand
#2
G Rahmani, J Martin-Smith, P Sullivan
Accidental self-inflicted knife injuries to digits are a common cause of tendon and nerve injury requiring hand surgery. There has been an apparent increase in avocado related hand injuries. Classically, the patients hold the avocado in their non-dominant hand while using a knife to cut/peel the fruit with their dominant hand. The mechanism of injury is usually a stabbing injury to the non-dominant hand as the knife slips past the stone, through the soft avocado fruit. Despite their apparent increased incidence, we could not find any cases in the literature which describe the "avocado hand"...
December 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29460456/acute-haemolysis-dic-and-renal-failure-after-transfusion-of-uncross-matched-blood-during-trauma-resuscitation-illustrative-case-and-literature-review
#3
J Fiorellino, A L Elahie, T E Warkentin
AIMS/OBJECTIVES: The aims of this study were to report a patient with acute haemolytic transfusion reaction (HTR) after transfusing uncross-matched red blood cell (RBC) units and to identify the frequency of this complication. BACKGROUND: Uncross-matched RBC units are commonly transfused in emergencies, but the frequency of acute HTR is unknown. METHODS: We describe a male stabbing victim who received three units of uncross-matched RBC units complicated by acute intravascular HTR, disseminated intravascular coagulation (DIC) and renal failure...
February 19, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29456360/clinical-features-and-psychiatric-comorbidity-of-epicrania-fugax
#4
K Rammohan, M M Shyma, Soumitra Das, C Velayudhan Shaji
Background: Epicrania fugax (EF) is a rare newly described primary headache characterized by paroxysms of unilateral pain radiating across one hemicranium. Aim: We aimed to describe 10 new cases of EF and assess the psychiatric comorbidity. Materials and Methods: Cases of EF were identified from patients attending the neurology outpatient department of a tertiary level referral and teaching hospital by the first author during a period extending from January 1, 2015 to April 31, 2017...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29446797/uncommon-pediatric-primary-headache-disorders
#5
M Cristina Victorio
Migraine and tension-type headaches are common primary headache disorders encountered among children and adolescents presenting to a pediatric clinic. At times, children present with a headache with unusual or peculiar features that can be alarming and perplexing. These can be in the form of a brief stabbing headache with lacrimation in one eye or a continuous headache locked to one side of the head or face. These headache syndromes tend to be more common among adults but, on occasion, are known to occur or have their onset during childhood...
February 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29443856/complications-in-tube-thoracostomy-systematic-review-and-meta-analysis
#6
Matthew C Hernandez, Moustafah El Khatib, Larry Prokop, Martin D Zielinski, Johnathon M Aho
BACKGROUND: Tube thoracostomy (TT) complications and their reported rates are highly variable (1-40%) and inconsistently classified. Consistent TT complication classification must be applied to compare reported literature to standardize TT placement. We aim to determine the overall TT related complication rates in patients receiving TT for traumatic indications utilizing uniform definitions. METHOD: Systematic review and meta-analysis was performed assessing TT related complications...
February 14, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29443759/a-traumatic-hepatic-artery-pseudoaneurysm-and-arterioportal-fistula-with-severe-diarrhea-as-the-first-symptom-a-case-report-and-review-of-the-literature
#7
Ping Han, Lan Yang, Xiao-Wei Huang, Xiu-Qin Zhu, Li Chen, Nan Wang, Zhen Li, De-An Tian, Hua Qin
RATIONALE: Hepaticarterioportal fistula (APF) is a rare cause of portal hypertension and gastrointestinal hemorrhage, and presents as abnormal communication between the hepatic artery and portal vein. Percutaneous liver biopsy is a main iatrogenic cause of AFP. However, non-iatrogenic, abdominal, trauma-related APF is rarely reported. PATIENT CONCERNS: A 29-year-old man presenting with severe, watery diarrhea was transferred to our hospital, and his condition was suspected to be acute gastroenteritis because he ate expired food and suffered a penetrating abdominal stab wound 5 years ago...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29438587/managing-penetrating-renal-trauma-experience-from-two-uk-major-trauma-centres
#8
Marios Hadjipavlou, Edmund Grouse, Robert Gray, Denosshan Sri, Dean Huang, Christian Brown, Davendra Sharma
OBJECTIVES: To present our series of patients with penetrating renal trauma from two urban major trauma centres and discuss contemporary management of these injuries. METHODS: We reviewed prospective urological trauma databases for all patients presenting with penetrating renal trauma between January 2005 and October 2016. Patient demographics, clinical characteristics, imaging, management and follow-up data were analysed. RESULTS: Over the 11 year period, 63 patients presented with penetrating renal injuries...
February 13, 2018: BJU International
https://www.readbyqxmd.com/read/29434169/different-patterns-in-abdominal-stab-wound-in-the-self-inflicted-and-assaulted-patients-an-observational-analysis-of-single-center-experience
#9
Takeshi Nishimura, Hiroyuki Sakata, Taihei Yamada, Mariko Terashima, Kunihiro Shirai, Isamu Yamada, Joji Kotani
Patterns of penetrating abdominal stab wounds (ASW) may be different according to the mechanism of injury. The purpose of this study was to review and characterize penetrating abdominal stab wounds in self-inflicted wound patients and assaulted patients. We retrospectively analyzed patients with ASW who were admitted to our emergency department from 2007 to 2015. The patients were divided into two groups: self-inflicted wound group and assaulted group. There were 46 stabbing cases in 45 different patients (25 males, 21 females; average age 47 y, range 21 to 85 y)...
July 20, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29428776/a-planned-complex-suicide-by-self-stabbing-and-vehicular-crash-an-original-case-and-review-of-the-literature
#10
Emilie Christin, Jean Hiquet, Jonathan Fougas, Olivier Dubourg, Sophie Gromb-Monnoyeur
Suicide is a frequent manner of unnatural death, especially from a forensic point of view. Complex suicide is defined as a recourse to more than one potentially lethal mechanism to deliberately induce death. This paper presents a complex suicide with a novel combination of self-killing methods. A 27 year-old man, working as a butcher, was found dead in his crashed car. The facts were initially in favour of an obvious traffic accident until a knife was discovered penetrating the driver's chest, requiring the police who were on the scene to carry out a criminal investigation...
January 31, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29427586/inhibition-of-human-tyrosinase-requires-molecular-motifs-distinctively-different-from-mushroom-tyrosinase
#11
Tobias Mann, Wolfram Gerwat, Jan Batzer, Kerstin Eggers, Cathrin Scherner, Horst Wenck, Franz Stäb, Vincent J Hearing, Klaus-Heinrich Röhm, Ludger Kolbe
Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target to inhibit hyperpigmentation. Numerous tyrosinase inhibitors have been identified, but most of those lack clinical efficacy because they were identified using mushroom tyrosinase as the target. Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Hydroquinone and its derivative arbutin only weakly inhibited human tyrosinase with a half-maximal inhibitory concentration (IC50) in the millimolar range, while kojic acid showed a weak efficacy (IC50 > 400 μM)...
February 7, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29413211/gastrointestinal-traumatic-injuries-gastrointestinal-perforation
#12
REVIEW
Maria A Revell, Marcia A Pugh, Melanie McGhee
The abdomen is a big place even in a small person. Gastrointestinal trauma can result in injury to the stomach, small bowel, colon, or rectum. Traumatic causes include blunt or penetrating trauma, such as gunshot wounds, stabbings, motor vehicle collisions, and crush injuries. Nontraumatic causes include appendicitis, Crohn disease, cancer, diverticulitis, ulcerative colitis, blockage of the bowel, and chemotherapy. The mechanism of injury will affect both the nature and severity of any resulting injuries. Treatment must address the critical and emergent nature of these injuries as well as issues that affect all trauma situations, which include management of hemodynamic instability...
March 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29411422/wnt-signaling-regulates-proliferation-and-differentiation-of-radial-glia-in-regenerative-processes-after-stab-injury-in-the-optic-tectum-of-adult-zebrafish
#13
Yuki Shimizu, Yuto Ueda, Toshio Ohshima
Zebrafish have superior abilities to generate new neurons in the adult brain and to regenerate brain tissue after brain injury compared with mammals. There exist two types of neural stem cells (NSCs): neuroepithelial-like stem cells (NE) and radial glia (RG) in the optic tectum. We established an optic tectum stab injury model to analyze the function of NSCs in the regenerative condition and confirmed that the injury induced the proliferation of RG, but not NE and that the proliferated RG differentiated into new neurons after the injury...
February 7, 2018: Glia
https://www.readbyqxmd.com/read/29410701/is-case-triaging-a-useful-tool-for-emergency-surgeries-a-review-of-106-trauma-surgery-cases-at-a-level-1-trauma-center-in-south-africa
#14
Sharfuddin Chowdhury, Andrew John Nicol, Mahammed Riyaad Moydien, Pradeep Harkison Navsaria, Luis Felipe Montoya-Pelaez
Background: The optimal timing for emergency surgical interventions and implementation of protocols for trauma surgery is insufficient in the literature. The Groote Schuur emergency surgery triage (GSEST) system, based on Cape Triaging Score (CTS), is followed at Groote Schuur Hospital (GSH) for triaging emergency surgical cases including trauma cases. The study aimed to look at the effect of delay in surgery after scheduling based on the GSEST system has an impact on outcome in terms of postoperative complications and death...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29402685/is-computed-tomography-tractography-reliable-in-patients-with-anterior-abdominal-stab-wounds
#15
İnanc Samil Sarici, Mustafa Uygar Kalayci
INTRODUCTION: The current literature and guidelines recommend that determination of peritoneal violation is done first in cases of anterior abdominal stab wounds. The primary endpoint of this study was to determine the reliability of computed tomographic (CT) tractography to assess peritoneal violation in anterior abdominal stab wounds. The secondary endpoint is to compare local wound exploration between conventional CT and CT tractography in the evaluation of peritoneal violation. MATERIAL AND METHODS: A total of 252 patients who were referred with anterior abdominal stab wounds were included in this prospective observational study...
February 2, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29395230/effects-of-intervertebral-disc-lesion-and-multifidus-muscle-resection-on-the-structure-of-the-lumbar-intervertebral-discs-and-paraspinal-musculature-of-the-rat
#16
Huub Maas, Wendy Noort, Paul W Hodges, Jaap van Dieën
The aim of this study was to investigate whether elimination of multifidus muscle in rats causes intervertebral disc (IVD) degeneration similar to that found after IVD lesion. Data were obtained from 36 male Wistar rats randomly assigned to one of three groups: (i) IVD lesion, in which the L4/L5 IVD was stabbed; (ii) multifidus muscle resection, in which all multifidus tissue between L3 and L6 was excised bilaterally; (iii) control, in which no intervention was applied. At 7, 14, and 28 days post-intervention, L4/L5 IVDs were harvested for histological analysis; left and right multifidus fascicles between L3 and S1 (from control and IVD lesion animals) and medial longissimus between L1 and S3 (from all animals) were dissected and weighed...
January 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29392073/transverse-cervicothoracic-stabbing-multidisciplinary-management-of-a-surgical-emergency
#17
Elena Molina Fernández, Ramón Moreno-Luna, Francisco López Navas, Marta López Porras, C Giménez, Serafín Sánchez Gómez
Tracheobronchial injuries are closely related to orotracheal intubations and chest traumas. Stabbing injuries are very rare and often life threatening because of the damage to vital structures such as the respiratory tract and large arterial or venous vessels. Early diagnosis and treatment of penetrating neck injuries increase survival rates. We report a case of the tracheobronchial section with a penetrating stabbing wound on the left laterocervical area associated with contralateral pneumothorax, requiring urgent surgical pulmonary repair, tracheal suture, and tracheotomy...
September 2017: Turkish Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29382004/acute-superior-mesenteric-vein-thrombosis-associated-with-abdominal-trauma-a-rare-case-report-and-literature-review
#18
Kyoung Hoon Lim, Jihoon Jang, Hye Young Yoon, Jinyoung Park
RATIONALE: Acute mesenteric vein thrombosis (MVT) is defined as new-onset thrombosis of the mesenteric vein without evidence of collateralization, finally resulting in extensive intestinal infarction. MVT may be idiopathic or be caused by conditions responsible for thrombophilia and acquired risk factors. To date, there have been few reports of MVT after trauma. Herein we describe our experiences treating three patients with MVT. PATIENT CONCERNS: Case 1 was a 44-year-old man with transverse colon mesenteric hematoma after blunt abdominal trauma...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29372857/early-experience-of-placing-image-guided-minimally-invasive-pedicle-screws-without-k-wires-or-bone-anchored-trackers
#19
Gregory M Malham, Rhiannon M Parker
OBJECTIVE Image guidance for spine surgery has been reported to improve the accuracy of pedicle screw placement and reduce revision rates and radiation exposure. Current navigation and robot-assisted techniques for percutaneous screws rely on bone-anchored trackers and Kirchner wires (K-wires). There is a paucity of published data regarding the placement of image-guided percutaneous screws without K-wires. A new skin-adhesive stereotactic patient tracker (SpineMask) eliminates both an invasive bone-anchored tracker and K-wires for pedicle screw placement...
January 26, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29369452/accuracy-of-computed-tomography-in-diagnosis-of-intra-abdominal-injuries-in-stable-patients-with-anterior-abdominal-stab-wounds-a-systematic-review-and-meta-analysis
#20
Bonny J Baron, Roshanak Benabbas, Casey Kohler, Carina Biggs, Valery Roudnitsky, Lorenzo Paladino, Richard Sinert
BACKGROUND: Work-up for patients presenting to the Emergency Department (ED) following an anterior abdominal stab wound (AASW) has been debated since the 1960s. Experts agree that patients with peritonitis, evisceration, or hemodynamic instability should undergo immediate laparotomy (LAP), however, workup of stable, asymptomatic or non-peritoneal, patients is not clearly defined. OBJECTIVES: To evaluate the accuracy of computed tomography of abdomen and pelvis (CTAP) for diagnosis of intra-abdominal injuries requiring Therapeutic Laparotomy (THER-LAP) in ED patients with AASW...
January 25, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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