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Polymyalgia

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https://www.readbyqxmd.com/read/29671039/three-days-of-high-dose-glucocorticoid-treatment-attenuates-large-vessel-18f-fdg-uptake-in-large-vessel-giant-cell-arteritis-but-with-a-limited-impact-on-diagnostic-accuracy
#1
Berit Dalsgaard Nielsen, Lars Christian Gormsen, Ib Tønder Hansen, Kresten Krarup Keller, Philip Therkildsen, Ellen-Margrethe Hauge
PURPOSE: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment. METHODS: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29669034/lung-involvement-in-polymyalgia-rheumatica
#2
Takeshi Kondo
No abstract text is available yet for this article.
April 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29600479/ct-analysis-of-the-aorta-in-giant-cell-arteritis-a-case-control-study
#3
Pierre Emmanuel Berthod, Serge Aho-Glélé, Paul Ornetti, Olivier Chevallier, Hervé Devilliers, Frédéric Ricolfi, Bernard Bonnotte, Romaric Loffroy, Maxime Samson
OBJECTIVES: Giant cell arteritis (GCA) is a large-vessel vasculitis whose diagnosis is confirmed by temporal artery biopsy. However, involvement of large vessels, especially the aorta, can be shown by imaging, which plays an increasing role in GCA diagnosis. The threshold above which aortic wall thickening, as measured by computed tomography (CT), is considered pathological is controversial, with values ranging from 2 to 3 mm. This study assessed aortic morphology by CT scan and its diagnostic value in GCA...
March 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29595283/-polymyalgia-rheumatica
#4
Petr Němec, Andrea Šprláková-Puková, Zdeněk Řehák
Polymyalgia rheumatica is the most frequent inflammatory disease of people over 50 years of age. It mainly affects the Caucasian race and roughly 2-3 times as many women. From the viewpoint of etiology, polymyalgia rheumatica is a complex disease. Involved in its origin is genetic predisposition, factors of age and outer environment. 16-21 % of patients with polymyalgia rheumatica may at the same time have symptoms of giant cell arteritis. Diagnosis is made primarily on the basis of clinical symptoms and it is supported by the presence of laboratory signs of inflammation...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29589404/update-on-treatment-of-polymyalgia-rheumatica
#5
D Camellino, C Dejaco
Polymyalgia rheumatica (PMR) is the second most common inflammatory rheumatic disease in the elderly after rheumatoid arthritis. It is clinically characterised by pain and stiffness in the neck, proximal shoulder and hip girdle. Glucocorticoids (GCs) are the cornerstone of PMR treatment, but they are associated with potentially severe side effects. Among GC-sparing agents, methotrexate revealed a modest benefit in clinical trials, and recently, there have been promising reports from tocilizumab. In this review, we summarize the available evidence on the treatment of PMR and the possible role in the future of other agents under investigation...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29589403/imaging-in-polymyalgia-rheumatica
#6
N Possemato, C Salvarani, N Pipitone
Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause clinically characterized by pain and prolonged morning stiffness affecting the shoulders and often the pelvic girdle and neck. Imaging has substantially contributed to defining PMR as a disease mainly involving extra-articular structures. This review article analyses the role of the different imaging techniques in the diagnosis and follow-up of patients with PMR with particular emphasis on the role of ultrasound, PET/CT and MRI...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29589402/the-role-of-the-general-practitioner-and-the-out-of-hospital-public-rheumatologist-in-the-diagnosis-and-follow-up-of-patients-with-polymyalgia-rheumatica
#7
A Sobrero, C Manzo, A Stimamiglio
Polymyalgia rheumatica (PMR) is a chronic inflammatory disease characterized by shoulder and pelvic girdle pain. Its onset peaks around the age of 75; the prevalence increases until the age of 90 and it is more frequent in females. Diagnosis is mostly performed on the basis of symptoms. An increase of serum inflammatory markers is indicative, but not essential, while therapy is mainly based on glucocorticoids. Since there is no universal agreement about diagnostic criteria for PMR, its detection is still difficult...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29589401/comorbidity-in-polymyalgia-rheumatica
#8
C Chatzigeorgiou, S L Mackie
Polymyalgia rheumatica (PMR) is the commonest inflammatory rheumatic disease affecting older people. The current mainstay of treatment is long-term oral glucocorticoid therapy. Management of these patients in clinical practice is often complicated by the presence of comorbidity. Comorbidity might be due to shared risk factors such as age, sex, or genetic background; to the presence of the disease itself; or to adverse effects of glucocorticoid therapy. Cardiovascular disease, osteoporosis/fracture, metabolic and ocular comorbidity are of particular interest to clinicians because of their relationship to glucocorticoid therapy and the relevance to clinical treatment decisions regarding glucocorticoid tapering...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29589400/the-real-evidence-for-polymyalgia-rheumatica-as-a-paraneoplastic-syndrome
#9
S Muller, S Hider, T Helliwell, R Partington, C Mallen
The aim of this study was to systematically consider the evidence for polymyalgia rheumatica (PMR) as a paraneoplastic disease. A systematic review of Medline and Embase was conducted from their inception to February 2017. Risk of bias was assessed using the Newcastle-Ottawa tool. Data were extracted regarding the PMR-cancer association, the types of cancer associated with PMR and the presentation of PMR patients subsequently diagnosed with cancer. Twenty-three full text articles were reviewed from the 1174 unique references identified in the search...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29589399/contribution-of-the-new-2012-eular-acr-classification-criteria-for-the-diagnosis-of-polymyalgia-rheumatica
#10
F Muratore, C Salvarani, P Macchioni
Polymyalgia rheumatica (PMR) is one of the most common rheumatic inflammatory disorders in people aged over 50. It is characterized by aching and prolonged morning stiffness in the shoulder and pelvic girdles and neck. To date there are no specific diagnostic tests, and in clinical practice the diagnosis of PMR remains based on its characteristic clinical manifestations, laboratory evidence of systemic inflammation, rapid response to low doses of glucocorticoids and exclusion of other disorders that may present with proximal pain and stiffness...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29589398/pathogenesis-of-polymyalgia-rheumatica
#11
G Guggino, A Ferrante, F Macaluso, G Triolo, F Ciccia
Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance between Th17 and Treg cells...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29589397/perspectives-and-unmet-needs-in-polymyalgia-rheumatica-providing-the-fundamental-framework-for-the-development-of-new-treatment-regimes-in-polymyalgia-rheumatica
#12
B D Nielsen, B Dasgupta
Polymyalgia rheumatica is effectively treated with glucocorticoids. However, glucocorticoid treatment can cause numerous and potentially serious side effects. Therefore, lowest effective dose and shortest duration to control disease is aimed for and glucocorticoid-sparing treatments are needed. Nevertheless, development of treatment regimens in PMR has been hampered by the lack of reliable classification criteria and evidence-based outcome measures. In this editorial, we discuss the need for valid classification criteria in PMR, the strengths and limitations of the ACR/EULAR 2012 provisional classification criteria for PMR and the need of validation and possible refining of the criteria...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29584608/utilization-of-a-viable-human-amnion-membrane-allograft-in-elderly-patients-with-chronic-lower-extremity-wounds-of-various-etiologies
#13
Matthew Regulski
ntroduction. Chronic nonhealing wounds are a growing health care problem in the United States, afflicting more than 6.5 million patients annually. In particular, diseases that compromise skin integrity and impair normal wound healing processes, such as diabetes and peripheral vascular diseases, are becoming more common in the aging population and leading to ever-increasing incidence of these chronic nonhealing wounds. OBJECTIVE: The aim of this study is to evaluate a viable human amnion membrane allograft (vHAMA) for the treatment of chronic nonhealing wounds in elderly patients (aged > 65 years) with multiple comorbidities...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29550251/18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-polymyalgia-rheumatica-screening-for-vasculitis
#14
Karla Arévalo Ruales, Rosa Negueroles Albuixech, José Loaiza Gongora, Elena Grau García, José Ivorra Cortés, José A Román Ivorra
OBJECTIVE: Polymyalgia rheumatica (PR) can be associated with large vessel vasculitis (LVV). We evaluate the diagnostic role of18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and its impact on the treatment of LVV associated with PR. MATERIALS AND METHODS: Retrospective study of patients diagnosed with PR. Data was collected from health records. Blood analysis included acute-phase reactants (APR), C-reactive protein (CRP) and erythrocyte sedimentation rate...
March 14, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29549493/negative-temporal-artery-biopsy-predictive-factors-for-giant-cell-arteritis-diagnosis-and-alternate-diagnoses-of-patients-without-arteritis
#15
Gil Bornstein, Iris Barshack, Nira Koren-Morag, Ilan Ben-Zvi, Nadav Furie, Chagai Grossman
To investigate whether among patients with a negative temporal artery biopsy (TAB) there are clinical features that may differentiate between patients with an eventual diagnosis of giant cell arteritis (GCA) and those without arteritis, and to assess the eventual diagnoses of patients without arteritis. Retrospective analysis of patients with a negative TAB performed between 1/1/2000 and 31/12/2015. Information collected included baseline clinical and laboratory data. Patients' final diagnoses were obtained from medical records...
March 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29545449/development-of-giant-cell-arteritis-after-treating-polymyalgia-or-peripheral-arthritis-a-retrospective-case-control-study
#16
Eric Liozon, Hubert de Boysson, François Dalmay, Guillaume Gondran, Holy Bezanahary, Anne-Laure Fauchais, Kim-Heang Ly
OBJECTIVE: We investigated the development of giant cell arteritis (GCA) in patients with prior diagnoses of isolated polymyalgia rheumatica and/or peripheral arthritis (PMR/PA), and the potentially relevant characteristics of both illnesses in such patients. METHODS: We retrospectively compared the features of 67 patients at the onset of PMR/PA, and their outcomes, to those of a random group of 65 patients with PMR/PA who did not develop late GCA. We also compared the features and outcomes of patients with late GCA to those of a random sample of patients with more usual GCA (65 with concurrent PMR/PA and 65 without)...
March 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29532268/monoclonal-gammopathy-in-rheumatic-diseases
#17
Yue Yang, Long Chen, Yuan Jia, Yang Liu, Lei Wen, Yaoxian Liang, Yuan An, Shi Chen, Yin Su, Zhanguo Li
To analyze the clinical spectrum, laboratory characteristics, and outcomes of monoclonal gammopathy (MG) in patients with rheumatic diseases. Screening for the presence of MG was performed in 872 inpatients with rheumatic diseases from January 2010 to July 2017. A total of 41 patients were enrolled. Their clinical and biological features in addition to outcomes were described. For each patient with primary Sjögren syndrome (pSS), 2 age- and sex-matched pSS patients without MG were selected as controls. Risk factors for the presence of MG and malignant hematological neoplasias were assessed...
March 13, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29531778/association-between-glucocorticoid-therapy-and-incidence-of-diabetes-mellitus-in-polymyalgia-rheumatica-and-giant-cell-arteritis-a-systematic-review-and-meta-analysis
#18
Lana Yin Hui Lai, Emma Harris, Robert M West, Sarah Louise Mackie
Background: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are almost always treated with glucocorticoids (GCs), but long-term GC use is associated with diabetes mellitus (DM). The absolute incidence of this complication in this patient group remains unclear. Objective: To quantify the absolute risk of GC-induced DM in PMR and GCA from published literature. Methods: We identified literature from inception to February 2017 reporting diabetes following exposure to oral GC in patients with PMR and/or GCA without pre-existing diabetes...
2018: RMD Open
https://www.readbyqxmd.com/read/29507455/prescribing-for-polymyalgia-rheumatic
#19
REVIEW
David F Liew, Claire E Owen, Russell R Buchanan
No abstract text is available yet for this article.
February 2018: Australian Prescriber
https://www.readbyqxmd.com/read/29476746/polymyalgia-rheumatica-with-normal-inflammatory-markers
#20
Shingo Suzuki, Yuta Hirose, Eriko Takeda, Masatomi Ikusaka
No abstract text is available yet for this article.
February 21, 2018: American Journal of Medicine
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