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https://www.readbyqxmd.com/read/28730843/clinical-value-of-st-segment-change-after-return-of-spontaneous-cardiac-arrest-and-emergent-coronary-angiography-in-patients-with-out-of-hospital-cardiac-arrest-diagnostic-and-therapeutic-importance-of-vasospastic-angina
#1
Kazuya Tateishi, Daisuke Abe, Tooru Iwama, Yuichi Hamabe, Kazutaka Aonuma, Akira Sato
BACKGROUND: We investigated the association between initial ST-segment change after return of spontaneous circulation (ROSC) and the incidence of acute coronary lesions in patients with out-of-hospital cardiac arrest (OHCA), and clinical outcomes of patients with OHCA caused by vasospastic angina pectoris (VSA). METHODS: Among 2779 OHCA patients in our institution, all patients with ROSC underwent emergent coronary angiography (CAG) except for those with an obvious extra-cardiac cause of OHCA...
July 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28729730/a-selective-inhibitor-of-histone-deacetylase-3-prevents-cognitive-deficits-and-suppresses-striatal-cag-repeat-expansions-in-huntington-s-disease-mice
#2
Nuria Suelves, Lucy Kirkham-McCarthy, Robert S Lahue, Silvia Ginés
Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The enzyme histone deacetylase 3 (HDAC3) appears to be important in HD pathology by negatively regulating genes involved in cognitive functions. Furthermore, HDAC3 has been implicated in the aberrant transcriptional patterns that help cause disease symptoms in HD mice. HDAC3 also helps fuel CAG repeat expansions in human cells, suggesting that HDAC3 may power striatal expansions in the HTT gene thought to drive disease progression...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28725076/continuing-medical-education-questions-july-2017-acg-and-cag-clinical-guideline-management-of-dyspepsia
#3
REVIEW
Ganesh R Veerappan
No abstract text is available yet for this article.
July 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28725067/continuing-medical-education-july-2017-acg-and-cag-clinical-guideline-management-of-dyspepsia
#4
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28720304/characterization-of-the-single-cell-derived-bovine-induced-pluripotent-stem-cells
#5
Lixia Zhao, Zixin Wang, Jindun Zhang, Jian Yang, Xuefei Gao, Baojiang Wu, Gaoping Zhao, Siqin Bao, Shuxiang Hu, Pentao Liu, Xihe Li
Single-cell derived bovine induced pluripotent stem cells (iPSCs) were generated by the introduction of piggyBac transposons with CAG promoting transcription factors (Oct3/4, Sox2, Klf4 and cMyc). In the study, the bovine iPSCs colony from single cell could passage more than 50 passages after enzymatic dissociation into single cells. These bovine iPSCs cells kept the normal karyotype and displayed dome shaped clones similar to mouse embryonic stem cells. They showed pluripotency in many ways, including their expression of pluripotency markers, such as OCT3/4, NANOG, SOX2, SSEA1, SSEA4, and AP in immunofluorescence assay, Oct4, Nanog, Sox2, Klf4 and cMyc in RT-PCR...
May 22, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28717775/impact-of-early-coronary-angiography-on-the-survival-to-discharge-after-out-of-hospital-cardiac-arrest
#6
Jikyoung Shin, Eunsil Ko, Won Chul Cha, Tae Rim Lee, Hee Yoon, Sung Yeon Hwang, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong, Jin-Ho Choi
OBJECTIVE: Acute myocardial infarction is a major cause of out-of-hospital cardiac arrest (OHCA). Coronary angiography (CAG) enables diagnostic confirmation of coronary artery disease and subsequent revascularization, which might improve the prognosis of OHCA survivors. Non-randomized data has shown a favorable impact of CAG on prognosis for this population. However, the optimal timing of CAG has been debated. METHODS: The clinical outcomes of 607 OHCA patients registered in CAPTURES (Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance), a nationwide multicenter registry performed in 27 hospitals, were analyzed...
June 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/28715800/the-efficacy-of-dienogest-in-the-treatment-of-simple-endometrial-hyperplasia-without-atypia
#7
Gulsum Uysal, Gokhan Acmaz, Yusuf Madendag, Fulya Cagli, Hatice Akkaya, Ilknur Madendag, Eda Ulku Karakilic
AIM: The aim of the study was to compare the effectiveness of dienogest (DIE), depo medroxyprogesterone 17-acetate (MPA), and micronized progesteron (MP) regimens for treatment of simple endometrial hyperplasia (EH) without atypia. METHODS: One hundred and twenty premenopausal patients aged between 35 and 55, with simple EH without atypia, were offered 3 types of progestins (MPA, MP, and DIE) and were randomized to one of them. After 6 months of treatment, patients were reevaluated...
July 15, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28715499/helicobacter-pylori-modulates-host-cell-responses-by-cagt4ss-dependent-translocation-of-an-intermediate-metabolite-of-lps-inner-core-heptose-biosynthesis
#8
Saskia C Stein, Eugenia Faber, Simon H Bats, Tatiana Murillo, Yvonne Speidel, Nina Coombs, Christine Josenhans
Highly virulent Helicobacter pylori cause proinflammatory signaling inducing the transcriptional activation and secretion of cytokines such as IL-8 in epithelial cells. Responsible in part for this signaling is the cag pathogenicity island (cagPAI) that codetermines the risk for pathological sequelae of an H. pylori infection such as gastric cancer. The Cag type IV secretion system (CagT4SS), encoded on the cagPAI, can translocate various molecules into cells, the effector protein CagA, peptidoglycan metabolites and DNA...
July 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28715425/elimination-of-huntingtin-in-the-adult-mouse-leads-to-progressive-behavioral-deficits-bilateral-thalamic-calcification-and-altered-brain-iron-homeostasis
#9
Paula Dietrich, Irudayam Maria Johnson, Shanta Alli, Ioannis Dragatsis
Huntington's Disease (HD) is an autosomal dominant progressive neurodegenerative disorder characterized by cognitive, behavioral and motor dysfunctions. HD is caused by a CAG repeat expansion in exon 1 of the HD gene that is translated into an expanded polyglutamine tract in the encoded protein, huntingtin (HTT). While the most significant neuropathology of HD occurs in the striatum, other brain regions are also affected and play an important role in HD pathology. To date there is no cure for HD, and recently strategies aiming at silencing HTT expression have been initiated as possible therapeutics for HD...
July 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28709491/band-pattern-analysis-of-mutations-in-rifampicin-resistance-strain-of-mycobacterium-tuberculosis-by-line-probe-assay-in-patients-from-delhi-india
#10
Himanshu Vashistha, M Hanif, K K Chopra, Ashwani Khanna, Divya Shrivastava
BACKGROUND: The GenoType MTBDRplus, a commercial Line Probe Assay (LPA) kit from Hain Lifescience, Germany, is endorsed by India's RNTCP Program for diagnosis of DRTB cases among smear-positive sputum samples. Although the LPA has been studied in several laboratories, there is a wide variation in existing M. tuberculosis strains across the globe, and false results can occur due to the presence of unique genetic mutations in different settings. AIM AND OBJECTIVE: An attempt was made to carry out band pattern analysis using LPA and also to observe uncommon mutations in MDR strains...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28701700/hdnetdb-a-molecular-interaction-database-for-network-oriented-investigations-into-huntington-s-disease
#11
Ravi Kiran Reddy Kalathur, José Pedro Pinto, Biswanath Sahoo, Gautam Chaurasia, Matthias E Futschik
Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as microarrays and mass-spectrometry has indicated multiple pathogenic routes. The massive data generated by these techniques together with the complexity of the pathogenesis, however, pose considerable challenges to researchers...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700998/a-decrease-of-histone-deacetylase-6-expression-caused-by-helicobacter-pylori-infection-is-associated-with-oncogenic-transformation-in-gastric-cancer
#12
Qing He, Guoqiang Li, Xin Wang, Shubin Wang, Jiang Hu, Lang Yang, Yuqi He, Yuanming Pan, Dedong Yu, Yun Wu
BACKGROUND: Histone deacetylase 6 (HDAC6) plays a role in the progression of many tumors. However, the relationship between the level of HDAC6 expression and gastric tumorigenesis is still unclear. Here, we illustrate the potential correlation between Helicobacter pylori (HP) infection and the variation of HDAC6 expression in different gastric lesions, as well as the clinical significance of HDAC6 expression in gastric cancer (GC) patients. MATERIALS AND METHODS: Between 2011 and 2016, 364 patients with different types of gastric lesions were enrolled in Baotou City Central Hospital...
July 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28700917/structure-and-dynamics-of-dna-and-rna-double-helices-of-cag-and-gac-trinucleotide-repeats
#13
Feng Pan, Viet Hoang Man, Christopher Roland, Celeste Sagui
CAG trinucleotide repeats are known to cause 10 late-onset progressive neurodegenerative disorders as the repeats expand beyond a threshold, whereas GAC repeats are associated with skeletal dysplasias and expand from the normal five to a maximum of seven repeats. The TR secondary structure is believed to play a role in CAG expansions. We have carried out free energy and molecular dynamics studies to determine the preferred conformations of the A-A noncanonical pairs in (CAG)n and (GAC)n trinucleotide repeats (n = 1, 4) and the consequent changes in the overall structure of the RNA and DNA duplexes...
July 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28700716/improved-high-sensitivity-screen-for-huntington-disease-using-a-one-step-triplet-primed-pcr-and-melting-curve-assay
#14
Mingjue Zhao, Felicia S H Cheah, Min Chen, Caroline G Lee, Hai-Yang Law, Samuel S Chong
Molecular diagnosis of Huntington disease (HD) is currently performed by fluorescent repeat-flanking or triplet-primed PCR (TP-PCR) with capillary electrophoresis (CE). However, CE requires multiple post-PCR steps and may result in high cost in high-throughput settings. We previously described a cost-effective single-step molecular screening strategy employing the use of melting curve analysis (MCA). However, because it relies on repeat-flanking PCR, its efficiency in detecting expansion mutations decreases with increasing size of the repeat, which could lead to false-negative results...
2017: PloS One
https://www.readbyqxmd.com/read/28700081/spinal-nociceptive-circuit-analysis-with-recombinant-adeno-associated-viruses-the-impact-of-serotypes-and-promoters
#15
Karen Haenraets, Edmund Foster, Helge Johannssen, Vinnie Kandra, Noemie Frezel, Timothy Steffen, Valeria Jaramillo, Jean-Charles Paterna, Hanns Ulrich Zeilhofer, Hendrik Wildner
Recombinant adeno-associated virus (rAAV) vector-mediated gene transfer into genetically defined neuron subtypes has become a powerful tool to study the neuroanatomy of neuronal circuits in the brain and to unravel their functions. More recently this methodology has also become popular for the analysis of spinal cord circuits. To date a variety of naturally occurring AAV serotypes and genetically modified capsid variants are available but transduction efficiency in spinal neurons, target selectivity and the ability for retrograde tracing are only incompletely characterized...
July 12, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28699830/cag-pathogenicity-island-dependent-up-regulation-of-matrix-metalloproteinase-7-in-infected-patients-with-helicobacter-pylori
#16
Marzieh Sadeghiani, Nader Bagheri, Heshmat Shahi, Somayeh Reiisi, Ghorbanali Rahimian, Reza Rashidi, Majid Mahsa, Mohammedhadi Shafigh, Elaheh Salimi, Mahmoud Rafieian-Kopaei, Morteza Hashemzadeh-Chaleshtori, Hedayatollah Shirzad
Helicobacter pylori (H. pylori) infection has been involved in the pathogenesis of most important gastroduodenal diseases. Matrix metalloproteinases (MMPs) are a family of secreted, zinc-dependent enzymes collectively capable of degradation of extracellular matrix (ECM) and key player in various inflammatory diseases. Therefore, we examined MMP-7 mRNA levels in the gastric mucosa of patients with H. pylori infection and evaluated the effects of virulence factors, such as vacA (vacuolating cytotoxin A) and cagA (cytotoxin-associated gene) in H...
July 12, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28695497/comparison-of-ctac-and-prone-imaging-for-the-detection-of-coronary-artery-disease-using-czt-spect
#17
Shimpei Ito, Akihiro Endo, Taiji Okada, Taku Nakamura, Takashi Sugamori, Nobuyuki Takahashi, Hiroyuki Yoshitomi, Kazuaki Tanabe
BACKGROUND: Cadmium-zinc-telluride (CZT) cameras have improved the evaluation of patients with chest pain. However, inferior/inferolateral attenuation artifacts similar to those seen with conventional Anger cameras persist. We added prone acquisitions and CT attenuation correction (CTAC) to the standard supine image acquisition and analyzed the resulting examinations. METHODS AND RESULTS: Seventy-two patients referred for invasive coronary angiography (CAG), and who also underwent rest/stress myocardial perfusion imaging (MPI) on a CZT camera in the supine and prone positions plus CTAC imaging, to examine known or suspected CAD between April 2013 and March 2014 were included...
July 10, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28695215/characterisation-of-a-stably-integrated-expression-system-for-exogenous-protein-expression-in-dt40
#18
Meliti Skouteri, Helfrid Hochegger, Antony M Carr
The use of constitutive promoters to drive exogenous protein expression is an important tool for the study of diverse biological processes. To create and characterise a stably integrated expression system for DT40 cells, we constructed integration cassettes for three commonly used promoter elements; CMV, CBA or CAG, and used these to stably integrate a TOPBP1 transgene at the OVA locus, a transcriptionally silent locus commonly used in DT40. We next performed a comparative analysis of protein expression levels and identified CAG as the most efficient of the promoter elements we have tested in DT40 cells...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28689403/fast-hydrolysis-polyesters-with-a-rigid-cyclic-diol-from-camphor
#19
Jeong Eon Park, Da Young Hwang, Gwang Ho Choi, Kyoung Hwan Choi, Dong Hack Suh
2,2:3,3-Bis(4'-hydroxymethylethylenedioxy)-1,7,7-trimethylbicyclo[2.2.1]heptane, abbreviated as CaG, is a compound obtained by transforming a ketone group to a ketal group with camphorquinone and glycerol. The CaG diol has a complex and rigid structure and two primary hydroxyl groups. A polyester series was synthesized with the CaG diol, ethylene glycol and dimethyl terephthalate. The polyesters exhibited adequate thermal stability up to nearly 330 oC and had a high Tg, which steadily increased from 78 oC to 129 oC as the content of CaG increased...
July 10, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28687202/aunp-ctg-based-probing-system-targeting-cag-repeat-dna-and-rna-sequences
#20
Binh Huy Le, Han Na Joo, Do Won Hwang, Kyu Wan Kim, Young Jun Seo
We have developed a AuNP-CTG based probing system that is applicable to the detection of many units of CAG repeat sequences which was synthesized by a rolling circle amplification (RCA) system with changes in fluorescence. We also demonstrate that our AuNP-CTG based probing system could transfect without using transfection reagent and detect target CAG repeat sequences in HeLa cells with dramatic changes in fluorescence. This AuNP-CTG based probing system could also be used, in conjunction with the CAG repeat RCA system, to detect target DNA...
June 27, 2017: Bioorganic & Medicinal Chemistry Letters
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