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https://www.readbyqxmd.com/read/28811347/tifa-signaling-in-gastric-epithelial-cells-initiates-the-cag-type-4-secretion-system-dependent-innate-immune-response-to-helicobacter-pylori-infection
#1
Alevtina Gall, Ryan G Gaudet, Scott D Gray-Owen, Nina R Salama
Helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing inflammation which, in some cases, leads to gastric ulcers and cancer. The clinical outcome of infection depends on a complex interplay of bacterial, host genetic, and environmental factors. Although H. pylori is recognized by both the innate and adaptive immune systems, this rarely results in bacterial clearance. Gastric epithelial cells are the first line of defense against H. pylori and alert the immune system to bacterial presence...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28810323/-the-efficacy-and-safety-of-the-patients-of-myelodysplastic-syndromes-refractory-anemia-with-excess-blasts-treated-with-decitabine-alone-or-cag-hag-regimen
#2
Z F Xu, T J Qin, H L Zhang, L W Fang, Y Zhang, L J Pan, N B Hu, S Q Qu, B Li, Z J Xiao
Objective: To observe the clinical efficacy and safety of the patients of myelodysplastic syndromes-refractory anemia with excess blasts (MDS-REAB) treated with decitabine alone or based on low dose cytarabine (Ara-C) regimen CAG/HAG [aclarubrci (ACR) /homoharring-tonine (HHT) +cytarabine+granulocyte colony stimulating factor (G-CSF) ]. Methods: Totally 121 patients with MDS-REAB were retrospectively analyzed, including 59 patients treated with decitabine alone (20 mg·m(-2)·d(-1) for 5 days) , the rest 62 ones treated with low-dose Ara-C-based regimen CAG/HAG...
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28803251/epidemiological-study-of-huntington-s-disease-in-the-province-of-ferrara-italy
#3
Erika Carrassi, Maura Pugliatti, Vittorio Govoni, Mariachiara Sensi, Ilaria Casetta, Enrico Granieri
BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the abnormal expansion of CAG triplet repeat. We aimed to reappraise HD epidemiology in a northern Italian population, in relation to introduction of genetic testing. METHODS: Through ICD-9M code 333.4 and medical fare exemption code RF0080, HD cases were identified from administrative health data and medical records from the Units of Neurology and Genetics, Ferrara University Hospital, and from other provincial neurological structures...
August 12, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28801427/effect-of-community-art-groups-on-retention-in-care-among-patients-on-art-in-tete-province-mozambique-a-cohort-study
#4
Tom Decroo, Barbara Telfer, Carla Das Dores, Richard A White, Natacha Dos Santos, Alec Mkwamba, Sergio Dezembro, Mariano Joffrisse, Tom Ellman, Carol Metcalf
OBJECTIVES: Estimate the effect of participation in Community ART Groups (CAG) versus individual care on retention-in-care (RIC) on antiretroviral therapy (ART). DESIGN: Retrospective cohort study. SETTING: High levels of attrition (death or loss-to-follow-up (LTFU) combined) on ART indicate that delivery models need to adapt in sub-Saharan Africa. In 2008, patients more than 6 months on ART began forming CAG, and took turns to collect ART refills at the health facility, in Tete Province, Mozambique,...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801221/the-aminoacyl-trna-synthetases-had-only-a-marginal-role-in-the-origin-of-the-organization-of-the-genetic-code-evidence-in-favor-of-the-coevolution-theory
#5
Massimo Di Giulio
The coevolution theory of the origin of the genetic code suggests that the organization of the genetic code coevolved with the biosynthetic relationships between amino acids. The mechanism that allowed this coevolution was based on tRNA-like molecules on which - this theory - would postulate the biosynthetic transformations between amino acids to have occurred. This mechanism makes a prediction on how the role conducted by the aminoacyl-tRNA synthetases (ARSs), in the origin of the genetic code, should have been...
August 9, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28799562/ophthalmic-features-of-spinocerebellar-ataxia-type-7
#6
A Campos-Romo, E O Graue-Hernandez, L Pedro-Aguilar, J C Hernandez-Camarena, D Rivera-De la Parra, V Galvez, R Diaz, A Jimenez-Corona, J Fernandez-Ruiz
PurposeTo analyze the relation between ophthalmologic and motor changes in spinocerebellar ataxia type 7 (SCA7).Patients and methodsThis was a case series study. Sixteen SCA7 patients underwent a comprehensive ophthalmic examination, including ocular extrinsic motility testing, color vision test, and optical coherence tomography of the optic nerve and macula. Changes in the corneal endothelium, electroretinographic patterns, and a complete neurologic evaluation using the Scale for the Assessment and Rating of Ataxia (SARA) were evaluated...
August 11, 2017: Eye
https://www.readbyqxmd.com/read/28798782/evaluation-of-local-carotid-stiffness-and-inflammatory-biomarkers-in-stable-angina-pectoris
#7
Abdullah Nabi Aslan, Ayşe Nur Özcan, Hüseyin Ayhan, Serkan Sivri, Filiz Çelebi, Karabekir Ercan, Tahir Durmaz
INTRODUCTION: Arterial stiffness (AS) is a well-accepted and reliable predictor of atherosclerotic diseases. Inflammation plays an important role in the development of AS. AIM: To evaluate local carotid stiffness (CS) together with fibrinogen and high-sensitivity C-reactive protein (hsCRP) levels in stable angina pectoris (SAP) patients. MATERIAL AND METHODS: The study consisted of 353 consecutive patients with SAP. All underwent coronary angiography (CAG) after the evaluation of local CS parameters and carotid intima-media thickness (IMT) from both common carotid arteries by a real-time echo-tracking system...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28792697/the-first-enterobacter-cloacae-co-producing-ndm-and-oxa-48-carbapenemases-and-interhospital-spread-of-oxa-48-and-ndm-producing-klebsiella-pneumoniae-in-turkey
#8
Demet Haciseyitoglu, Aysegul Dokutan, Ayham Abulaila, Fatma Erdem, Yasemin Cag, Serdar Ozer, Zerrin Aktas
BACKGROUND: The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae. METHODS: A total of 54 carbapenem nonsusceptible Enterobacteriaceae (CRE) isolates were recovered from clinical samples sent to the Dr. Lutfi Kirdar Kartal Training and Research Hospital from the period 2011 through 2014. Forty-four isolates were Klebsiella pneumoniae (CRKP) and the other 10 were Enterobacter cloacae (CREC).The isolate identifications and antibiotic sensitivity tests were performed using a Vitek2 automatic system...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792249/induced-neural-stem-cells-as-a-means-of-treatment-in-huntington-s-disease
#9
Kyung-Ah Choi, Sunghoi Hong
Huntington's disease (HD) is an inherited neurodegenerative disease characterized by chorea, dementia, and depression caused by progressive nerve cell degeneration, which is triggered by expanded CAG repeats in the huntingtin (Htt) gene. Currently, there is no cure for this disease, nor is there an effective medicine available to delay or improve the physical, mental, and behavioral severities caused by it. Areas covered: In this review, the authors describe the use of induced neural stem cells (iNSCs) by direct conversion technology, which offers great advantages as a therapeutic cell type to treat HD...
August 9, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28789621/tics-as-an-initial-manifestation-of-juvenile-huntington-s-disease-case-report-and-literature-review
#10
Shi-Shuang Cui, Ru-Jing Ren, Ying Wang, Gang Wang, Sheng-Di Chen
BACKGROUND: Huntington's disease (HD) is an autosomal dominant disorder, typically characterized by chorea due to a trinucleotide repeat expansion in the HTT gene, although the clinical manifestations of patients with juvenile HD (JHD) are atypical. CASE PRESENTATION: A 17-year-old boy with initial presentation of tics attended our clinic and his DNA analysis demonstrated mutation in the HTT gene (49 CAG repeats). After treatment, his symptoms improved. Furthermore, we performed literature review through searching the databases and summarized clinical features in 33 JHD patients...
August 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28782341/genetic-screening-for-spinocerebellar-ataxia-genes-in-a-japanese-single-hospital-cohort
#11
Ryuji Sakakibara, Fuyuki Tateno, Masahiko Kishi, Yohei Tsuyusaki, Yosuke Aiba, Hitoshi Terada, Tsutomu Inaoka, Setsu Sawai, Satoshi Kuwabara, Fumio Nomura
Objective: Diagnosis of sporadic cerebellar ataxia is a challenge for neurologists. A wide range of potential causes exist, including chronic alcohol use, multiple system atrophy of cerebellar type (MSA-C), and sporadic late cortical cerebellar atrophy. Recently, an autosomal-dominant spinocerebellar ataxia (SCA) mutation was identified in a cohort of patients with non-MSA-C sporadic cerebellar ataxia. The aim of this study is to genetically screen genes involved in SCA in a Japanese single-hospital cohort...
August 8, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28780115/foreign-gene-expression-and-induction-of-antibody-response-by-recombinant-fowl-adenovirus-9-based-vectors-with-exogenous-promoters
#12
James G Ackford, Juan C Corredor, Yanlong Pei, Peter J Krell, Grégoy Bédécarrats, E Va Nagy
Fowl adenoviruses (FAdVs) are promising vectors for poultry vaccines and gene therapy. The commonly used human cytomegalovirus (CMV) promoter in recombinant FAdV-9 viruses (recFAdV-9s) leads to foreign gene expression that elicits an antibody response. Despite its strength, studies have shown that the CMV promoter is prone to silencing by methylation hampering the in vivo application of vectors containing this promoter. Therefore, to improve our virus vector system and circumvent potential limitations of silencing, we engineered recFAdV-9s with foreign gene expression cassettes carrying the CMV enhancer/chicken β-actin (CAG) or the human elongation factor 1 alpha (EF1α) promoters with or without the posttranscriptional regulatory element of woodchuck hepatitis virus (WPRE)...
August 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28774347/microrna-dysregulation-in-polyglutamine-toxicity-of-tata-box%C3%A2-binding-protein-is-mediated-through-stat1-in-mouse-neuronal-cells
#13
Reema Roshan, Ashwani Choudhary, Aksheev Bhambri, Bhawani Bakshi, Tanay Ghosh, Beena Pillai
BACKGROUND: Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in the N-terminal of TBP is the causal mutation in SCA17. Brain sections of patients with spinocerebellar ataxia 17 (SCA17), a type of neurodegenerative disease, have been reported to contain protein aggregates of TATA-binding protein (TBP). It is also implicated in other neurodegenerative diseases like Huntington's disease, since the protein aggregates formed in such diseases also contain TBP...
August 3, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28774346/tall-stature-a-difficult-diagnosis
#14
REVIEW
Cristina Meazza, Chiara Gertosio, Roberta Giacchero, Sara Pagani, Mauro Bozzola
Referral for an assessment of tall stature is less common than for short stature. Tall stature is defined as a height more than two standard deviations above the mean for age. The majority of subjects with tall stature show a familial tall stature or a constitutional advance of growth (CAG), which is a diagnosis of exclusion. After a careful physical evaluation, tall subjects may be divided into two groups: tall subjects with normal appearance and tall subjects with abnormal appearance. In the case of normal appearance, the paediatric endocrinologist will have to evaluate the growth rate...
August 3, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28770594/multi-month-prescriptions-fast-track-refills-and-community-art-groups-results-from-a-process-evaluation-in-malawi-on-using-differentiated-models-of-care-to-achieve-national-hiv-treatment-goals
#15
REVIEW
Margaret L Prust, Clement K Banda, Rose Nyirenda, Frank Chimbwandira, Thokozani Kalua, Andreas Jahn, Michael Eliya, Katie Callahan, Peter Ehrenkranz, Marta R Prescott, Elizabeth A McCarthy, Elya Tagar, Andrews Gunda
INTRODUCTION: In order to facilitate scale-up of antiretroviral therapy (ART) in Malawi, innovative and pragmatic models have been developed to optimize the efficiency of HIV service delivery. In particular, three models of differentiated care have emerged for stable patients: adjusted appointment spacing through multi-month scripting (MMS); fast-track drug refills (FTRs) on alternating visits; and community ART groups (CAGs) where group members rotate in collecting medications at the facility for all members...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770241/analysis-of-synonymous-codon-usage-bias-and-phylogeny-of-coat-protein-gene-in-banana-bract-mosaic-virus-isolates
#16
Atul B Patil, Vijayendra S Dalvi, Akhilesh A Mishra, Bal Krishna, Abdul Azeez
The banana is one of the world's most important livelihood crops. Banana plants are principally infected by four virus species, Banana bunchy top virus (genus Babuvirus), Cucumber mosaic virus (genus Cucumovirus), Banana streak virus (genus Badnavirus) and Banana bract mosaic virus (genus Potyvirus). The objective of this study is to understand the codon usage pattern and phylogeny of coat protein gene in different banana bract mosaic virus (BBrMV) isolates. The BBrMV Coat Protein (CP) gene was amplified from BBrMV infected banana plant samples collected from different districts of Tamil Nadu and Karnataka, India...
June 2017: Virusdisease
https://www.readbyqxmd.com/read/28769566/association-of-left-ventricular-ejection-fraction-with-contrast-induced-nephropathy-and-mortality-following-coronary-angiography-or-intervention-in-patients-with-heart-failure
#17
Kun Wang, Hua-Long Li, Wei-Jie Bei, Xiao-Sheng Guo, Shi-Qun Chen, Sheikh Mohammed Shariful Islam, Ji-Yan Chen, Yong Liu, Ning Tan
BACKGROUND: Left ventricular ejection fraction (LVEF) is the most widely used parameter to evaluate the cardiac function in patients with heart failure (HF). However, the association between LVEF and contrast-induced nephropathy (CIN) is still controversial. Therefore, the aim of this study is to evaluate the association of LVEF with CIN and long-term mortality following coronary angiography (CAG) or intervention in patients with HF. METHODS: We analyzed 1,647 patients with HF (New York Heart Association [NYHA] or Killip class >1) undergoing CAG or intervention, including 207 (12...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28767406/effect-of-trimetazidine-on-preventing-contrast-induced-nephropathy-in-diabetic-patients-with-renal-insufficiency
#18
Ziliang Ye, Haili Lu, Qiang Su, Xinhua Xian, Lang Li
BACKGROUND: Our study sought to assess the effect of trimetazidine (TMZ) on preventing contrast-induced nephropathy (CIN) in diabetic patients with renal insufficiency. MATERIALS AND METHODS: 106 diabetic patients with renal insufficiency who were undergoing coronary angiography (CAG) and/or percutaneous coronary intervention (PCI) were enrolled in this study. Standard hydration was administered to both groups (the TMZ group and the control group). In the TMZ group, patients were orally administered TMZ for 48 hours before and 24 hours after CAG and/or PCI...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765068/5-trna-halves-are-dysregulated-in-clear-cell-renal-cell-carcinoma
#19
Chenming Zhao, Yuri Tolkach, Doris Schmidt, Glen Kristiansen, Stefan C Müller, Jörg Ellinger
PURPOSE: tRNA fragments are dysregulated in various malignancies. Our study was designed to determine the expression of four 5'-tRNA-halves in tissue and serum of clear cell renal cell carcinoma (ccRCC) patients. MATERIALS AND METHODS: Tissue and serum samples of patients with ccRCC and non-malignant disease were collected prospectively in our Biobank. We isolated total RNA from 95 ccRCC and 50 normal renal tissues as well as serum RNA from 27 patients with ccRCC and 13 with non-malignant urological diseases...
July 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28763160/crispr-cas9-mediated-targeting-of-the-rosa26-locus-produces-cre-reporter-rat-strains-for-monitoring-cre-loxp-mediated-lineage-tracing
#20
Yuanwu Ma, Lei Yu, Shuo Pan, Shan Gao, Wei Chen, Xu Zhang, Wei Dong, Jing Li, Rui Zhou, Lan Huang, Yunlin Han, Lin Bai, Li Zhang, Lianfeng Zhang
The rat is an important laboratory animal for physiological, toxicological and pharmacological studies. CRISPR/Cas9 is a simple and efficient tool to generate precise genetic modifications in rats, which will promote the accumulation of rat genetic resources and enable more precise studies of gene function. To monitor Cre/loxP-mediated excision in vivo, we generated a Cre reporter rat strain (Rosa26-imCherry) by knockin of a Cre reporter cassette at Rosa26 locus using CRISPR/Cas9. Rosa26-imCherry rats exhibited inducible expression of the mCherry cassette (imCherry) using the Cre/loxP system, whereas normal rats exhibited ubiquitous expression of eGFP but not mCherry in the whole body...
August 1, 2017: FEBS Journal
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