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https://www.readbyqxmd.com/read/28210799/dynamic-contrast-enhanced-mr-imaging-pharmacokinetic-parameters-as-predictors-of-treatment-response-of-brain-metastases-in-patients-with-lung-cancer
#1
Grégory Kuchcinski, Emilie Le Rhun, Alexis B Cortot, Elodie Drumez, Romain Duhal, Maxime Lalisse, Julien Dumont, Renaud Lopes, Jean-Pierre Pruvo, Xavier Leclerc, Christine Delmaire
OBJECTIVES: To determine the diagnostic accuracy of pharmacokinetic parameters measured by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in predicting the response of brain metastases to antineoplastic therapy in patients with lung cancer. METHODS: Forty-four consecutive patients with lung cancer, harbouring 123 newly diagnosed brain metastases prospectively underwent conventional 3-T MRI at baseline (within 1 month before treatment), during the early (7-10 weeks) and midterm (5-7 months) post-treatment period...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28159433/-mri-of-the-pulmonary-parenchyma-towards-clinical-applicability
#2
REVIEW
G Dournes, J Macey, E Blanchard, P Berger, F Laurent
Lung parenchyma has long been considered out of the scope of magnetic resonance imaging (MRI) clinical applicability. However, technological advances have emerged to soluce the technical difficulties and thus, applications in clinical practice have become realistic. Nevertheless, various approaches have been proposed and there is a need to synthetize the most recent literature data in order to envision a rationale to build lung MR protocols for clinical use. In addition, these technological innovations may modify the usual paradigms of lung MRI, which are still not consensual...
January 31, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28145723/ultrasmall-silica-based-bismuth-gadolinium-nanoparticles-for-dual-magnetic-resonance-computed-tomography-image-guided-radiation-therapy
#3
Alexandre Detappe, Eloise Thomas, Mark W Tibbitt, Sijumon Kunjachan, Oksana Zavidij, Nishita Parnandi, Elizaveta Reznichenko, François Lux, Olivier Tillement, Ross Berbeco
Selective killing of cancer cells while minimizing damage to healthy tissues is the goal of clinical radiation therapy. This therapeutic ratio can be improved by image-guided radiation delivery and selective radiosensitization of cancer cells. Here, we have designed and tested a novel trimodal theranostic nanoparticle made of bismuth and gadolinium for on-site radiosensitization and image contrast enhancement to improve the efficacy and accuracy of radiation therapy. We demonstrate in vivo magnetic resonance (MR), computed tomography (CT) contrast enhancement, and tumor suppression with prolonged survival in a non-small cell lung carcinoma model during clinical radiation therapy...
February 2, 2017: Nano Letters
https://www.readbyqxmd.com/read/28126915/mixed-responses-to-systemic-therapy-revealed-potential-genetic-heterogeneity-and-poor-survival-in-patients-with-non-small-cell-lung-cancer
#4
Zhong-Yi Dong, Hao-Ran Zhai, Qing-Yi Hou, Jian Su, Si-Yang Liu, Hong-Hong Yan, Yang-Si Li, Zhi-Yong Chen, Wen-Zhao Zhong, Yi-Long Wu
BACKGROUND: A subset of patients with non-small cell lung cancer (NSCLC) fosters mixed responses (MRs) to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) or chemotherapy. However, little is known about the clinical and molecular features or the prognostic significance and potential mechanisms. METHODS: The records of 246 consecutive patients with NSCLC receiving single-line chemotherapy or TKI treatment and who were assessed by baseline and interim positron emission tomography/computed tomography scans were collected retrospectively...
January 2017: Oncologist
https://www.readbyqxmd.com/read/28124411/imaging-for-the-exclusion-of-pulmonary-embolism-in-pregnancy
#5
REVIEW
Thijs E van Mens, Luuk Jj Scheres, Paulien G de Jong, Mariska Mg Leeflang, Mathilde Nijkeuter, Saskia Middeldorp
BACKGROUND: Pulmonary embolism is a leading cause of pregnancy-related death. An accurate diagnosis in pregnant patients is crucial to prevent untreated pulmonary embolism as well as unnecessary anticoagulant treatment and future preventive measures. Applied imaging techniques might perform differently in these younger patients with less comorbidity and altered physiology, who largely have been excluded from diagnostic studies. OBJECTIVES: To determine the diagnostic accuracy of computed tomography pulmonary angiography (CTPA), lung scintigraphy and magnetic resonance angiography (MRA) for the diagnosis of pulmonary embolism during pregnancy...
January 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28117930/quantitative-assessment-of-lung-stiffness-in-patients-with-interstitial-lung-disease-using-mr-elastography
#6
John P Marinelli, David L Levin, Robert Vassallo, Rickey E Carter, Rolf D Hubmayr, Richard L Ehman, Kiaran P McGee
PURPOSE: To investigate the use of magnetic resonance elastography (MRE) in the quantitative assessment of pulmonary fibrosis by comparing quantitative shear stiffness measurements of lung parenchyma in patients diagnosed with fibrotic interstitial lung disease (ILD) and healthy controls. MATERIALS AND METHODS: A 1.5T spin-echo, echo planar imaging MRE (SE-EPI MRE) pulse sequence was utilized to assess absolute lung shear stiffness in 15 patients with diagnosed ILD and in 11 healthy controls...
January 24, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28102958/sliding-window-prior-data-assisted-compressed-sensing-for-mri-tracking-of-lung-tumors
#7
Eugene Yip, Jihyun Yun, Keith Wachowicz, Zsolt Gabos, Satyapal Rathee, B G Fallone
PURPOSE: Hybrid magnetic resonance imaging and radiation therapy devices are capable of imaging in real-time to track intrafractional lung tumor motion during radiotherapy. Highly accelerated magnetic resonance (MR) imaging methods can potentially reduce system delay time and/or improves imaging spatial resolution, and provide flexibility in imaging parameters. Prior Data Assisted Compressed Sensing (PDACS) has previously been proposed as an acceleration method that combines the advantages of 2D compressed sensing and the KEYHOLE view-sharing technique...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102957/rf-safety-assessment-of-a-bilateral-four-channel-transmit-receive-7-tesla-breast-coil-sar-versus-tissue-temperature-limits
#8
Thomas M Fiedler, Mark E Ladd, Andreas K Bitz
PURPOSE: The purpose of this work was to perform an RF safety evaluation for a bilateral four-channel transmit/receive breast coil and to determine the maximum permissible input power for which RF exposure of the subject stays within recommended limits. The safety evaluation was done based on SAR as well as on temperature simulations. In comparison to SAR, temperature is more directly correlated with tissue damage, which allows a more precise safety assessment. The temperature simulations were performed by applying three different blood perfusion models as well as two different ambient temperatures...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28092203/machine-learning-of-three-dimensional-right-ventricular-motion-enables-outcome-prediction-in-pulmonary-hypertension-a-cardiac-mr-imaging-study
#9
Timothy J W Dawes, Antonio de Marvao, Wenzhe Shi, Tristan Fletcher, Geoffrey M J Watson, John Wharton, Christopher J Rhodes, Luke S G E Howard, J Simon R Gibbs, Daniel Rueckert, Stuart A Cook, Martin R Wilkins, Declan P O'Regan
Purpose To determine if patient survival and mechanisms of right ventricular failure in pulmonary hypertension could be predicted by using supervised machine learning of three-dimensional patterns of systolic cardiac motion. Materials and Methods The study was approved by a research ethics committee, and participants gave written informed consent. Two hundred fifty-six patients (143 women; mean age ± standard deviation, 63 years ± 17) with newly diagnosed pulmonary hypertension underwent cardiac magnetic resonance (MR) imaging, right-sided heart catheterization, and 6-minute walk testing with a median follow-up of 4...
January 16, 2017: Radiology
https://www.readbyqxmd.com/read/28076290/tailored-interactive-sequences-for-continuous-mr-image-guided-freehand-biopsies-of-different-organs-in-an-open-system-at-1-0-tesla-t-initial-experience
#10
Florian Streitparth, Christian Althoff, Martin Jonczyk, Felix Guettler, Martin Maurer, Hendrik Rathke, Keno Moritz Sponheuer, Bernd Hamm, Ulf K Teichgräber, Maximilian de Bucourt
OBJECTIVES: To assess the feasibility, image quality, and accuracy of freehand biopsies of liver, bone, muscle, vertebral disc, soft tissue, and other lesions using balanced steady-state free precession (SSFP, balanced fast field echo: bFFE), spoiled and nonspoiled gradient echo (FFE), and turbo spin echo (TSE) sequences for interactive continuous navigation in an open magnetic resonance imaging (MRI) system at 1.0 tesla (T). METHODS: Twenty-six MR-guided biopsies (five liver, five bone, four muscle, four vertebral disc, one lung, one kidney, one suprarenal gland, and five soft or other tissue) were performed in 23 patients in a 1...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076009/delineating-extramammary-findings-at-breast-mr-imaging
#11
Yiming Gao, Opeyemi Ibidapo, Hildegard K Toth, Linda Moy
Breast magnetic resonance (MR) imaging is the only breast imaging modality that consistently encompasses extramammary structures in the thorax and upper abdomen. Incidental extramammary findings on breast MR images of patients with a history of breast cancer or other malignancies are significantly more likely to be malignant and may affect staging and treatment. An understanding of the frequency, distribution, and context of extramammary findings on breast MR images and a familiarity with common and uncommon sites of breast cancer metastasis inform the differential diagnosis and prompt the appropriate diagnostic next step, to differentiate benign from malignant findings...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28061534/overcoming-the-challenges-associated-with-symptom-management-in-palliative-care
#12
Helen Senderovich, Shaira Wignarajah
End of life (EOL) care is a topic that many families have difficulty discussing. A number of families are uncomfortable with accepting the fact that death is a part of every human's reality. Ideas and thoughts of death are interpreted differently across various cultures, and lacking to discuss disease trajectory and what to expect down the road with a physician, brings forward conflict during EOL care. Let us consider the complexities of treating Mr. X who is an 80-year-old male of Italian background with a history of advanced lung cancer with metastasis to the brain...
November 30, 2016: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28061502/brain-abscesses-associated-with-asymptomatic-pulmonary-arteriovenous-fistulas
#13
Taek-Kyun Nam, Yong-Sook Park, Jeong-Taik Kwon
Brain abscess commonly occurs secondary to an adjacent infection (mostly in the middle ear or paranasal sinuses) or due to hematogenous spread from a distant infection or trauma. Pulmonary arteriovenous fistulas (AVFs) are abnormal direct communications between the pulmonary artery and vein. We present two cases of brain abscess associated with asymptomatic pulmonary AVF. A 65-year-old woman was admitted with a headache and cognitive impairment that aggravated 10 days prior. An magnetic resonance (MR) imaging revealed a brain abscess with severe edema in the right frontal lobe...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28050694/survival-prediction-using-temporal-muscle-thickness-measurements-on-cranial-magnetic-resonance-images-in-patients-with-newly-diagnosed-brain-metastases
#14
Julia Furtner, Anna S Berghoff, Omar M Albtoush, Ramona Woitek, Ulrika Asenbaum, Daniela Prayer, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Bernadette Aretin, Rupert Bartsch, Christoph C Zielinski, Veronika Schöpf, Matthias Preusser
OBJECTIVES: To evaluate the prognostic relevance of temporal muscle thickness (TMT) in brain metastasis patients. METHODS: We retrospectively analysed TMT on magnetic resonance (MR) images at diagnosis of brain metastasis in two independent cohorts of 188 breast cancer (BC) and 247 non-small cell lung cancer (NSCLC) patients (overall: 435 patients). RESULTS: Survival analysis using a Cox regression model showed a reduced risk of death by 19% with every additional millimetre of baseline TMT in the BC cohort and by 24% in the NSCLC cohort...
January 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28048894/su-f-i-58-image-quality-comparisons-of-different-motion-magnitudes-and-tr-values-in-mr-pet
#15
J Patrick, M Tavallaei, R Thompson, R Stodilka, M Drangova, S Gaede
PURPOSE: The aim of this work is to evaluate the accuracy and sensitivity of a respiratory-triggered MR-PET protocol in detecting four different sized lesions at two different magnitudes of motion, with two different TR values, using a novel PET-MR-CT compatible respiratory motion phantom. METHODS: The eight-compartment torso phantom was setup adjacent to the motion stage, which moved four spherical compartments (28, 22, 17, 10 mm diameter) in two separate (1 and 2 cm) linear motion profiles, simulating a 3...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048706/tu-ab-bra-06-best-in-physics-joint-imaging-therapy-an-mri-compatible-externally-and-internally-deformable-lung-motion-phantom-for-multi-modality-igrt
#16
P Sabouri, T Arai, A Sawant
PURPOSE: MRI has become an attractive tool for tumor motion management. Current MR-compatible phantoms are only capable of reproducing translational motion. This study describes the construction and validation of a more realistic, MRI-compatible lung phantom that is deformable internally as well as externally. We demonstrate a radiotherapy application of this phantom by validating the geometric accuracy of the open-source deformable image registration software NiftyReg (UCL, UK). METHODS: The outer shell of a commercially-available dynamic breathing torso phantom was filled with natural latex foam with eleven water tubes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048527/su-f-t-544-development-of-a-clinically-feasible-workflow-of-4d-mri-based-treatment-planning-for-liver-sbrt
#17
S Han, F Yin, B Czito, M Palta, J Cai
PURPOSE: To develop a clinically feasible workflow of 4D MRI-based treatment planning for liver SBRT. METHODS: A clinical workflow based on 4D MRI for liver SBRT was designed to largely simulate the same procedure as 4D CT for lung SBRT. Key features of the workflow include: (1) contouring tumor volume at each phases (2) contouring more structures, (3) assigning CT numbers to structures for dose calculation. Uncertainties (bone delineation, MRI distortion, CT number assignment, etc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048360/mo-b-201-03-mri-guided-tracking-and-gating
#18
O Green
: The motion management in stereotactic body radiation therapy (SBRT) is a key to success for a SBRT program, and still an on-going challenging task. A major factor is that moving structures behave differently than standing structures when examined by imaging modalities, and thus require special considerations and employments. Understanding the motion effects to these different imaging processes is a prerequisite for a decent motion management program. The commonly used motion control techniques to physically restrict tumor motion, if adopted correctly, effectively increase the conformity and accuracy of hypofractionated treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048323/su-d-207a-05-investigating-sparse-sampled-mri-for-motion-management-in-thoracic-radiotherapy
#19
P Sabouri, T Arai, A Sawant
PURPOSE: Sparse sampling and reconstruction-based MRI techniques represent an attractive strategy to achieve sufficiently high image acquisition speed while maintaining image quality for the task of radiotherapy guidance. In this study, we examine rapid dynamic MRI using a sparse sampling sequence k-t BLAST in capturing motion-induced, cycle-to-cycle variations in tumor position. We investigate the utility of long-term MRI-based motion monitoring as a means of better characterizing respiration-induced tumor motion compared to a single-cycle 4DCT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048275/su-f-j-168-dosimetric-impact-of-mr-image-distortion-in-treatment-planning
#20
Y Yan, J Yang, S Beddar, G Ibbott, P Balter, R Kudchadker, S Krishnan, C Fuller, J Wang
PURPOSE: To evaluate the dosimetric impact of MR image distortion in treatment planning. METHODS: Based on the realistic MRI distortion measurement data from an integrated MRI-Linac system, we created a generalized distortion model and applied it to CT images to simulate distorted MRI images. Ten patients with IMRT plans generated in Pinnacle treatment planning system in 5 anatomical cancer sites (lung, prostate, spinal cord, liver, and pancreas) were retrospectively selected for the simulation...
June 2016: Medical Physics
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