keyword
MENU ▼
Read by QxMD icon Read
search

microRNA lipid

keyword
https://www.readbyqxmd.com/read/29050310/microrna-27b-inhibition-promotes-nrf2-are-pathway-activation-and-alleviates-intracerebral-hemorrhage-induced-brain-injury
#1
Wenzhe Xu, Feng Li, Zhiguo Liu, Zhenkuan Xu, Bin Sun, Jingwei Cao, Yuguang Liu
Oxidative stress and neuroinflammation are the key factors leading to secondary brain injury after intracerebral hemorrhage (ICH). We investigated the effects of miR-27b, an oxidative stress-responsive microRNA, on ICH-induced brain injury in rats. The ICH model was induced by intracerebral injection of collagenase. Following ICH, miR-27b expression in the striatum was reduced, whereas expression of Nrf2 mRNA and protein was increased. In PC12 cells, overexpression of miR-27b reduced expression of Nrf2, Hmox1, Sod1 and Nqo1, while miR-27b inhibition had the opposite effects...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050192/-advances-in-research-of-exosomes-and-age-related-macular-degeneration
#2
M Q Xu, X D Sun
Exosomes are small vesicles with a molecular diameter of 30 to 100 nm, which are secreted into the cell after the fusion of the multivesicular bodies with the plasma membrane. Exosomes contain various molecular constituents of their cell origin, including proteins, microRNAs and lipids. Different cell-derived exosomes have different biological functions. Exosomes play a very important role in the development and progression of age-related macular degeneration (AMD). The exosomes derived from the eye are involved in the processes of cell growth, metastasis, angiogenesis and immunosuppression by transferring contents to adjacent or distant cells...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043382/cell-transfer-of-information-via-mir-loaded-exosomes-a-biophysical-approach
#3
C Potrich, L Lunelli, V Vaghi, L Pasquardini, C Pederzolli
A new communication route among cells was reported in recent years, via extracellular vesicles and their cargo. Exosomes in particular are attracting increasing interest as privileged mediators of this cell communication route. The exosome-mediated transfer of nucleic acids, especially of microRNAs, is particularly promising for their use both as biomarkers of pathologies and as a therapeutic tool. Here, a simplified model of interaction among cells, microRNAs and vesicles is studied using a biophysical approach...
October 17, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29028873/mirna-in-tumour-metabolism-and-why-could-it-be-the-preferred-pathway-for-energy-reprograming
#4
Aliaa A Alamoudi, Amina Alnoury, Hoda Gad
The current literature on the role of microRNA (miRNA) in tumour metabolism is growing, and a number of studies regularly confirm the impact miRNA can have in energy reprograming in tumours. However, there remains to be a lack of understanding of the larger perspective of the role of miRNA in the metabolism story. In the first part of this review, we provide a comprehensive and up-to-date description of the extensive role of miRNAs in tumour metabolism including glucose, lipid and amino acid metabolism. However, in the second part, we aim to provide a description of the multidimensional role miRNA can be playing in tumour metabolism...
September 23, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29027986/effects-of-conjugated-linoleic-acid-supplementation-on-the-expression-profile-of-mirnas-in-porcine-adipose-tissue
#5
Qi Wang, Renli Qi, Hong Liu, Jing Wang, Wenming Huang, Feiyun Yang, Jinxiu Huang
Conjugated linoleic acids (CLAs) play a major role in adipocyte differentiation and lipid metabolism in animals. MicroRNAs (miRNAs) appear to be involved in many biological processes in adipose tissue. However, the specific influence on miRNAs by CLA supplementation in porcine adipose tissue remains unclear. Thus, we continuously added 1.5% CLA to the pig diet from the embryo stage to the finishing period and conducted a high-throughput sequencing approach to analyse the changes in adipose tissue miRNAs. We identified 283 known porcine miRNAs, and 14 miRNAs were differentially expressed in response to CLA treatment...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29024380/cell-to-cell-communication-micrornas-as-hormones
#6
REVIEW
Recep Bayraktar, Katrien Van Roosbroeck, George A Calin
Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell-to-cell communication within the tumor microenvironment. EVs' components, such as proteins, non-coding RNAs [microRNAs (miRNAs) and long non-coding RNAs (lncRNAs)], messenger RNAs (mRNAs), DNA, and lipids, can mediate paracrine signaling in the tumor microenvironment. Recently, miRNAs encapsulated in secreted EVs have been identified in the extracellular space...
October 11, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29020847/neurolipids-and-microrna-changes-in-blood-following-blast-traumatic-brain-injury-in-mice-an-exploratory-study
#7
Venkata Siva Sai Sujith Sajja, Anna Jablonska, Norman J Haughey, Jeff W M Bulte, Robert D Stevens, Joseph Long, Piotr Walczak, Miroslaw Janowski
At present, accurate and reliable biomarkers to ascertain the presence, severity, or prognosis of blast traumatic brain injury (bTBI) are lacking. There is an urgent need to establish accurate and reliable biomarkers capable of mbTBI detection. Currently, there are no studies that identify changes in miRNA and lipids at varied severities of bTBI. Various biological components such as lipids, circulating mRNA, and miRNA, could potentially be detected using advanced techniques such as next-generation sequencing and mass spectroscopy...
October 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29018475/the-microrna-interaction-network-of-lipid-diseases
#8
Abdul H Kandhro, Watshara Shoombuatong, Chanin Nantasenamat, Virapong Prachayasittikul, Pornlada Nuchnoi
Background: Dyslipidemia is one of the major forms of lipid disorder, characterized by increased triglycerides (TGs), increased low-density lipoprotein-cholesterol (LDL-C), and decreased high-density lipoprotein-cholesterol (HDL-C) levels in blood. Recently, MicroRNAs (miRNAs) have been reported to involve in various biological processes; their potential usage being a biomarkers and in diagnosis of various diseases. Computational approaches including text mining have been used recently to analyze abstracts from the public databases to observe the relationships/associations between the biological molecules, miRNAs, and disease phenotypes...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29016843/mesenchymal-stem-cells-as-natural-bio-factories-for-exosomes-carrying-mir-124a-in-the-treatment-of-gliomas
#9
Frederick M Lang, Anwar Hossain, Joy Gumin, Eric N Momin, Yuzaburo Shimizu, Dan Ledbetter, Tal Shahar, Shinji Yamashita, Brittany Parker-Kerrigan, Juan Fueyo, Raymond Sawaya, Frederick F Lang
Background: MicroRNAs (miRs) are promising new therapeutics for glioblastoma. However, which miRs are most effective against glioblastomas and how these miRs should be delivered are major unanswered problems. Methods: To identify potent anti-glioma miRs, we selected eight miRs based on a literature search and screened them against a panel of glioma stem cell lines (GSCs), representing all TCGA-defined glioblastoma subtypes. To address delivery, we tested the hypothesis that ex vivo-cultured bone marrow-derived mesenchymal stem cells (MSCs) can package miRs into exosomes and that these engineered exosomes can systemically deliver antiglioma miRs to glioblastomas...
August 14, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28994547/-explore-molecular-mechanism-of-chinese-herbs-with-promoting-blood-circulation-and-resolving-phlegm-effects-on-myocardial-ischemia-reperfusion-injury-based-on-correlation-between-microrna-and-mtdna
#10
Fei Lin, Heng-Wen Chen, Zhuo-Lin Shi, Guo-An Zhao, Ye-Xi Sun
A large number of basic and clinical studies have shown that the Chinese herbs with promoting blood circulation and resolving phlegm effects could prevent and treat myocardial ischemia-reperfusion injury(MIRI) by regulating lipid metabolism. But its mechanism is not yet clear. The studies show that mitochondrial DNA (mtDNA), microRNAs and lipid metabolism participate in the whole process of MIRI and affect the prognosis. mtDNA mutation is the primary factor to cause myocardial ischemia and reperfusion myocardial cell damage...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28986361/regulating-microrna-expression-at-the-heart-of-diabetes-mellitus-and-the-mitochondrion
#11
Quincy A Hathaway, Mark V Pinti, Andrya J Durr, Shanawar Waris, Danielle L Shepherd, John M Hollander
Type 2 diabetes mellitus is a major risk factor for cardiovascular disease and mortality. Uncontrolled type 2 diabetes mellitus results in a systemic milieu of increased circulating glucose and fatty acids. The development of insulin resistance in cardiac tissue decreases cellular glucose import and enhances mitochondrial fatty acid uptake. While triacylglycerol and cytotoxic lipid species begin to accumulate in the cardiomyocyte, the energy substrate utilization ratio of free fatty acids (FFAs) to glucose changes to almost entirely FFAs...
October 6, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28979765/micrornas-in-the-development-and-neoplasia-of-the-mammary-gland
#12
REVIEW
Manoj Kumar Jena
Study on the role of microRNAs (miRs) as regulators of gene expression through posttranscriptional gene silencing is currently gaining much interest,due to their wide involvement in different physiological processes. Understanding mammary gland development, lactation, and neoplasia in relation to miRs is essential. miR expression profiling of the mammary gland from different species in various developmental stages shows their role as critical regulators of development. miRs such as miR-126, miR-150, and miR-145 have been shown to be involved in lipid metabolism during lactation...
2017: F1000Research
https://www.readbyqxmd.com/read/28965750/emerging-role-of-extracellular-vesicles-in-musculoskeletal-diseases
#13
REVIEW
Cameron Murphy, Joseph Withrow, Monte Hunter, Yutao Liu, Yao Liang Tang, Sadanand Fulzele, Mark W Hamrick
Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the proteins, lipids, mRNAs, and microRNAs (miRNAs) transported by EVs. We have recently discovered a role for exosome-derived miRNAs in age-related bone loss and osteoarthritis, two conditions that impose a significant public health burden on the aging global population...
October 10, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28964725/how-mirs-and-mrna-deadenylases-could-post-transcriptionally-regulate-expression-of-tumor-promoting-protein-pld
#14
REVIEW
Julian Gomez-Cambronero, Kristen Fite, Taylor E Miller
Phospholipase D (PLD) plays a key role in both cell membrane lipid reorganization and architecture, as well as a cell signaling protein via the product of its enzymatic reaction, phosphatidic acid (PA). PLD is involved in promoting breast cancer cell growth, proliferation, and metastasis and both gene and protein expression are upregulated in breast carcinoma human samples. In spite of all this, the ultimate reason as to why PLD expression is high in cancer cells vs. their normal counterparts remains largely unknown...
August 24, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28951211/microrna-194-inhibition-improves-dietary-induced-non-alcoholic-fatty-liver-disease-in-mice-through-targeting-on-fxr
#15
Hezhongrong Nie, Chunli Song, Daming Wang, Shengjin Cui, Tingyu Ren, Zhaopeng Cao, Qing Liu, Zeyan Chen, Xiaoyong Chen, Yiwen Zhou
Non-alcoholic fatty liver disease (NAFLD) affects obesity-associated metabolic syndrome, which exhibits hepatic steatosis, insulin insensitivity and glucose intolerance. Previous studies indicated that hepatic microRNAs (miRs) play critical roles in the development of NAFLD. In this study, we aim to explore the pathophysiological role of miR-194 in obesity-mediated metabolic dysfunction. Our findings show that the high fat diet or palmitic acid treatment significantly increase hepatic miR-194 levels in vivo and in vitro...
September 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28947967/mir-33a-is-a-tumor-suppressor-microrna-that-is-decreased-in-prostate-cancer
#16
Omer Faruk Karatas, Jianghua Wang, Longjiang Shao, Mustafa Ozen, Yiqun Zhang, Chad J Creighton, Michael Ittmann
Prostate cancer is one of the most frequently diagnosed neoplasms among men worldwide. MicroRNAs (miRNAs) are involved in numerous important cellular processes including proliferation, differentiation and apoptosis. They have been found to be aberrantly expressed in many types of human cancers. They can act as either tumor suppressors or oncogenes, and changes in their levels are associated with tumor initiation, progression and metastasis. miR-33a is an intronic miRNA embedded within SREBF2 that has been reported to have tumor suppressive properties in some cancers but has not been examined in prostate cancer...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28941357/microrna-in-alzheimer-s-disease-revisited-implications-for-major-neuropathological-mechanisms
#17
Reihaneh Dehghani, Farzaneh Rahmani, Nima Rezaei
Pathology of Alzheimer's disease (AD) goes far beyond neurotoxicity resulting from extracellular deposition of amyloid β (Aβ) plaques. Aberrant cleavage of amyloid precursor protein and accumulation of Aβ in the form of the plaque or neurofibrillary tangles are the known primary culprits of AD pathogenesis and target for various regulatory mechanisms. Hyper-phosphorylation of tau, a major component of neurofibrillary tangles, precipitates its aggregation and prevents its clearance. Lipid particles, apolipoproteins and lipoprotein receptors can act in favor or against Aβ and tau accumulation by altering neural membrane characteristics or dynamics of transport across the blood-brain barrier...
September 23, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28938482/microrna-221-3p-regulates-angiopoietin-like-8-angptl8-expression-in-adipocytes
#18
Raghavendra Mysore, Francisco J Ortega, Jèssica Latorre, Maria Ahonen, Hanna Savolainen-Peltonen, Pamela Fischer-Posovszky, Martin Wabitsch, Vesa M Olkkonen, José M Fernández-Real, P A Nidhina Haridas
Context: Angiopoietin-like 8 (ANGPTL8) has been identified as a key regulator of lipid metabolism. Design: We addressed the correlation between ANGPTL8 mRNA with hallmark insulin-regulated and lipogenic genes in human adipose tissue. The regulation of ANGPTL8 expression in adipocytes was studied after inflammatory challenge, and the role of microRNA-221-3p therein was investigated. Results: ANGPTL8 gene expression in subcutaneous (SAT) and visceral (VAT) adipose tissue was highly correlated with SLC2A4/GLUT4 and ADIPOQ/Adiponectin...
August 30, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28936736/pathological-effects-of-exosomes-in-mediating-diabetic-cardiomyopathy
#19
Esam S B Salem, Guo-Chang Fan
Diabetic subjects are at risk of developing cardiovascular disease, which accounts for 60-80% of diabetes-related mortality. Atherosclerosis is still considered as a leading cause of heart failure in diabetic patients, but it could also be an intrinsic and long-term effect of contractile cardiac cells malfunction, known as diabetic cardiomyopathy (DCM). Pathologically, this cardiac dysfunction is manifested by inflammation, apoptosis, fibrosis, hypertrophy and altered cardiomyocytes metabolism. However, the underlying molecular mechanisms of DCM pathophysiology are not clearly understood...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936730/exosomes-nanocarriers-of-biological-messages
#20
Alice Conigliaro, Simona Fontana, Stefania Raimondo, Riccardo Alessandro
Cell-cell communication is crucial to maintain homeostasis in multicellular organism. Cells communicate each other by direct contact or by releasing factors that, soluble or packaged in membrane vesicles, can reach different regions of the organism. To date numerous studies highlighted the existence of several types of extracellular vesicles that, differing for dimension, origin and contents, play a role in physiological and/or pathological processes. Among extracellular vesicles, exosomes are emerging as efficient players to modulate target cells phenotype and as new non-invasive diagnostic and prognostic tools in multiple diseases...
2017: Advances in Experimental Medicine and Biology
keyword
keyword
76078
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"