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https://www.readbyqxmd.com/read/28088385/flavonoid-derivative-fla-cn-inhibited-adipocyte-differentiation-via-activating-ampk-and-up-regulating-microrna-27-in-3t3-l1-cells
#1
Chun-Chun Gan, Tian-Wen Ni, Yang Yu, Nan Qin, Ying Chen, Mei-Na Jin, Hong-Quan Duan
Fla-CN (3-O-[(E)-4-(4-cyanophenyl)-2-oxobut-3-en-1-yl] kaempferol) is a semi-synthesized flavonoid derivative of tiliroside which exhibited anti-diabetic effect in vivo. Our previous study revealed the role of Fla-CN in anti-obesity and anti-diabetes in vivo, but the underlying mechanism remained to be addressed. The present study aimed to investigate the mechanism of anti-adipogenesis in vitro. Fla-CN markedly inhibited intracellular lipid accumulation in a dose-dependent manner, and the inhibitory effect was mainly limited to the early stage of adipocyte differentiation in vitro...
January 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28077443/single-dose-intracardiac-injection-of-pro-regenerative-micrornas-improves-cardiac-function-after-myocardial-infarction
#2
Pierluigi Lesizza, Giulia Prosdocimo, Valentina Martinelli, Gianfranco Sinagra, Serena Zacchigna, Mauro Giacca
RATIONALE: Recent evidence indicates that a few human microRNAs (miRNAs), in particular hsa-miR-199a-3p and hsa-miR-590-3p, stimulate proliferation of cardiomyocytes and, once expressed in the mouse heart using viral vectors, induce cardiac regeneration after myocardial infarction. Viral vectors, however, are not devoid of safety issues and, more notably, drive expression of the encoded miRNAs for indefinite periods of time, which might not be desirable in light of human therapeutic application...
January 11, 2017: Circulation Research
https://www.readbyqxmd.com/read/28067602/mirnas-in-cerebrospinal-fluid-identify-patients-with-ms-and-specifically-those-with-lipid-specific-oligoclonal-igm-bands
#3
Ester Quintana, Francisco José Ortega, René Robles-Cedeño, María Luisa Villar, Maria Buxó, Josep Maria Mercader, José Carlos Alvarez-Cermeño, Neus Pueyo, Héctor Perkal, José Manuel Fernández-Real, Lluís Ramió-Torrentà
BACKGROUND: MicroRNAs (miRNAs) are non-coding RNAs that regulate cellular processes by controlling protein translation and mRNA degradation. OBJECTIVE: We aimed to explore the miRNA signature of multiple sclerosis (MS) patients versus controls and the possibility that patients with lipid-specific oligolconal IgM bands (LS_OCMB), a predictor of a more severe disease course, may have a distinct profile. METHODS: An extensive profile of 754 miRNAs was evaluated in the cerebrospinal fluid (CSF) of 14 women using TaqMan low-density arrays...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28063231/exosomes-nanoparticulate-tools-for-rna-interference-and-drug-delivery
#4
REVIEW
Fahimeh Shahabipour, Nastaran Barati, Thomas P Johnston, Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar
Exosomes are naturally occurring extracellular vesicles released by most mammalian cells in all body fluids. Exosomes are known as key mediators in cell-cell communication and facilitate the transfer of genetic and biochemical information between distant cells. Structurally, exosomes are composed of lipids, proteins, and also several types of RNAs which enable these vesicles to serve as important disease biomarkers. Moreover, exosomes have emerged as novel drug and gene delivery tools owing to their multiple advantages over conventional delivery systems...
January 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28062296/relationship-between-circulating-microrna-30c-with-total-and-ldl-cholesterol-their-circulatory-transportation-and-effect-of-statins
#5
Ravinder Sodi, Jarlath Eastwood, Muriel Caslake, Chris J Packard, Laura Denby
BACKGROUND: Small non-coding microRNAs (miR) have important regulatory roles and are used as biomarkers of disease. We investigated the relationship between lipoproteins and circulating miR-30c, evaluated how they are transported in circulation and determined whether statins altered the circulating concentration of miR-30c. METHODS: To determine the relationship between lipoproteins and circulating miR-30c, serum samples from 79 subjects recruited from a lipid clinic were evaluated...
January 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28051030/epigallocatechin-3-gallate-modulates-microrna-expression-profiles-in-human-nasopharyngeal-carcinoma-cne2-cells
#6
Bin-Bin Li, Guo-Liang Huang, Hua-Hui Li, Xia Kong, Zhi-Wei He
BACKGROUND: Epigallocatechin-3-gallate (EGCG) has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma (NPC), but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the expression of microRNAs (miRNAs) in NPC cells. METHODS: Using microarray analysis, the alterations of miRNA expression profiles were investigated in EGCG-treated CNE2 cells...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28025059/microrna-206-prevents-hepatosteatosis-and-hyperglycemia-by-facilitating-insulin-signaling-and-impairing-lipogenesis
#7
Heng Wu, Tianpeng Zhang, Fei Pan, Clifford J Steer, Zhuoyu Li, Xin Chen, Guisheng Song
BACKGROUND & AIMS: The paradox of selective hepatic insulin resistance, wherein the insulin-resistant liver fails to suppress glucose production but continues to produce lipids, has been central to the pathophysiology of hepatosteatosis and hyperglycemia. Our study was designed to investigate the mechanism(s) by which microRNA-206 alleviates the pathogenesis of hepatosteatosis and hyperglycemia. METHODS: Dietary obese mice induced by a high fat diet were used to study the role of microRNA-206 in the pathogenesis of hepatosteatosis and hyperglycemia...
December 23, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28008089/extracellular-vesicles-their-role-in-cancer-biology-and-epithelial-mesenchymal-transition
#8
REVIEW
Shashi K Gopal, David W Greening, Alin Rai, Maoshan Chen, Rong Xu, Adnan Shafiq, Rommel A Mathias, Hong-Jian Zhu, Richard J Simpson
Cell-cell communication is critical across an assortment of physiological and pathological processes. Extracellular vesicles (EVs) represent an integral facet of intercellular communication largely through the transfer of functional cargo such as proteins, messenger RNAs (mRNAs), microRNA (miRNAs), DNAs and lipids. EVs, especially exosomes and shed microvesicles, represent an important delivery medium in the tumour micro-environment through the reciprocal dissemination of signals between cancer and resident stromal cells to facilitate tumorigenesis and metastasis...
January 1, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28007904/cellular-biochemical-and-molecular-changes-in-muscles-from-patients-with-x-linked-myotubular-myopathy-due-to-mtm1-mutations
#9
Christoph Bachmann, Heinz Jungbluth, Francesco Muntoni, Adnan Y Manzur, Francesco Zorzato, Susan Treves
Centronuclear myopathies are early-onset muscle diseases caused by mutations in several genes including MTM1, DNM2, BIN1, RYR1 and TTN The most severe and often fatal X-linked form of myotubular myopathy (XLMTM) is caused by mutations in the gene encoding the ubiquitous lipid phosphatase myotubularin, an enzyme specifically dephosphorylating phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Because XLMTM patients have a predominantly muscle-specific phenotype a number of pathogenic mechanisms have been proposed, including a direct effect of the accumulated lipid on the skeletal muscle calcium channel ryanodine receptor 1, a negative effect on the structure of intracellular organelles and defective autophagy...
December 22, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28003747/microrna-200c-delivered-by-solid-lipid-nanoparticles-enhances-the-effect-of-paclitaxel-on-breast-cancer-stem-cell
#10
Jingwen Liu, Tingting Meng, Ming Yuan, Lijuan Wen, Bolin Cheng, Na Liu, Xuan Huang, Yun Hong, Hong Yuan, Fuqiang Hu
BACKGROUND: One of the major obstacles in the treatment of breast cancer is breast cancer stem cells (BCSC) which are resistant to standard chemotherapeutic drugs. It has been proven that microRNA-200c (miR-200c) can restore sensitivity to microtubule-targeting chemotherapeutic drugs by reducing the expression of class III β-tubulin. In this study, combination therapy with miR-200c and paclitaxel (PTX) mediated by lipid nanoparticles was investigated as an alternative strategy against BCSC...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27994555/physiological-adjustments-and-circulating-microrna-reprogramming-are-involved-in-early-acclimatization-to-high-altitude-in-chinese-han-males
#11
Bao Liu, He Huang, Shou-Xian Wang, Gang Wu, Gang Xu, Bing-Da Sun, Er-Long Zhang, Yu-Qi Gao
Background: Altitude acclimatization is a physiological process that restores oxygen delivery to the tissues and promotes oxygen use under high altitude hypoxia. High altitude sickness occurs in individuals without acclimatization. Unraveling the molecular underpinnings of altitude acclimatization could help understand the beneficial body responses to high altitude hypoxia as well as the altered biological events in un-acclimatized individuals. This study assessed physiological adjustments and circulating microRNA (cmiRNA) profiles in individuals exposed to high altitude, aiming to explore altitude acclimatization in humans...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27989131/integrative-omics-analysis-in-primary-human-hepatocytes-unravels-persistent-mechanisms-of-cyclosporine-a-induced-cholestasis
#12
Jarno E J Wolters, Marcel H M van Herwijnen, Daniel H J Theunissen, Danyel G J Jennen, Wim F P M Van den Hof, Theo M C M de Kok, Frank G Schaap, Simone G J van Breda, Jos C S Kleinjans
Cyclosporine A (CsA) is an undecapeptide with strong immunosuppressant activities and is used a lot after organ transplantation. Furthermore, it may induce cholestasis in the liver. In general, the drug-induced cholestasis (DIC) pathway includes genes involved in the uptake, synthesis, conjugation, and secretion of bile acids. However, whether CsA-induced changes in the cholestasis pathway in vitro are persistent for repeated dose toxicity has not yet been investigated. To explore this, primary human hepatocytes (PHH) were exposed to a subcytotoxic dose of 30 μM CsA daily for 3 and 5 days...
December 19, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27987357/micrornas-in-lipoprotein-and-lipid-metabolism-from-biological-function-to-clinical-application
#13
Véronique Desgagné, Luigi Bouchard, Renée Guérin
microRNAs (miRNAs) are short (~22 nucleotides), non-coding, single-stranded RNA molecules that regulate the expression of target genes by partial sequence-specific base-pairing to the targeted mRNA 3'UTR, blocking its translation, and promoting its degradation or its sequestration into processing bodies. miRNAs are important regulators of several physiological processes including developmental and metabolic functions, but their concentration in circulation has also been reported to be altered in many pathological conditions such as familial hypercholesterolemia, cardiovascular diseases, obesity, type 2 diabetes, and cancers...
December 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27982021/circulating-exosomes-and-exosomal-micrornas-as-biomarkers-in-gastrointestinal-cancer
#14
REVIEW
R Nedaeinia, M Manian, M H Jazayeri, M Ranjbar, R Salehi, M Sharifi, F Mohaghegh, M Goli, S H Jahednia, A Avan, M Ghayour-Mobarhan
The most important biological function of exosomes is their possible use as biomarkers in clinical diagnosis. Compared with biomarkers identified in conventional specimens such as serum or urine, exosomal biomarkers provide the highest amount of sensitivity and specificity, which can be attributed to their excellent stability. Exosomes, which harbor different types of proteins, nucleic acids and lipids, are present in almost all bodily fluids. The molecular constituents of exosomes, especially exosomal proteins and microRNAs (miRNAs), are promising as biomarkers in clinical diagnosis...
December 16, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27966196/micrornas-33-122-and-208-a-potential-novel-targets-in-the-treatment-of-obesity-diabetes-and-heart-related-diseases
#15
REVIEW
Osama Abo Alrob, Said Khatib, Saleh A Naser
Despite decades of research, obesity and diabetes remain major health problems in the USA and worldwide. Among the many complications associated with diabetes is an increased risk of cardiovascular diseases, including myocardial infarction and heart failure. Recently, microRNAs have emerged as important players in heart disease and energy regulation. However, little work has investigated the role of microRNAs in cardiac energy regulation. Both human and animal studies have reported a significant increase in circulating free fatty acids and triacylglycerol, increased cardiac reliance on fatty acid oxidation, and subsequent decrease in glucose oxidation which all contributes to insulin resistance and lipotoxicity seen in obesity and diabetes...
December 14, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27956176/glucagon-like-peptide-1-effects-lipotoxic-oxidative-stress-by-regulating-the-expression-of-micrornas
#16
Zhiying Zhang, Huifang Liu, Qiang Li
Aim to confirm whether the treatment of GLP-1 can modulated body weight, lipid metabolism, insulin content, pancreas oxidative stress, improved T-AOC, MDA levels related to FFA-Induced oxidative stress in C57BL/6 mice and INS-1 cells. In this study, GLP-1 makes the expression of AMPK, PPARα, CPT1A and SIRT1 increased, and the expression of SREBP1c, miR-33 and miR-370 decreased. Interestingly, the effects of GLP-1 were less dose dependent as GLP-1 regulated the FFA, which related to gene expression at much lower doses (3 μg/kg, 10 mM, mice and INS-1 respectively) and effects were relatively maintained at higher dose (30 μg/kg, 100 mM, mice and INS-1 respectively) as well...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27939617/hypoxia-mimetic-induces-lipid-accumulation-through-mitochondrial-dysfunction-and-stimulates-autophagy-in-murine-preadipocyte-cell-line
#17
Ana Patrícia Marques, Joana Rosmaninho-Salgado, Marta Estrada, Vera Cortez, Rui Jorge Nobre, Cláudia Cavadas
BACKGROUND: Hypoxia occurs within adipose tissue of obese human and mice. However, its role in adipose tissue regulation is still controversial. METHODS: We used murine preadipocyte 3T3-L1 cells and hypoxia was induced by using hypoxia mimetic agents, as CoCl2. To study adipocyte differentiation, we evaluated the adipocyte markers (PPARγ, C/EBPα and aP2), and a preadipocyte marker (Pref-1) by qPCR, western blotting and immunofluorescence. Lipid accumulation was evaluated by Oil red-O assay and by analyzing perilipin levels by western blotting and immunofluorescence...
December 8, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27939101/bio-compartmentalization-of-micrornas-in-exosomes-during-gestational-diabetes-mellitus
#18
REVIEW
Juvita D Iljas, Dominic Guanzon, Omar Elfeky, Gregory E Rice, Carlos Salomon
Analysis of the human genome revealed that only 1.2% encoded for proteins, which raised questions regarding the biological significance of the remaining genome. We now know that approximately 80% of the genome serves at least one biochemical function within the cell. A portion of this 80% consists of a family of non-coding regulatory RNAs, one important member being microRNAs (miRNAs). miRNAs can be detected in tissues and biofluids, where miRNAs in the latter can be bound to proteins or encapsulated within lipid vesicles such as exosomes...
December 2, 2016: Placenta
https://www.readbyqxmd.com/read/27929413/exosome-proteome-of-u-87mg-glioblastoma-cells
#19
Sohyun Chun, Seunghyun Ahn, Chang-Hwan Yeom, Seyeon Park
Exosomes are small membrane vesicles between 30 and 100 nm in diameter secreted by many cell types, and are associated with a wide range of physiological and/or pathological processes. Exosomes containing proteins, lipids, mRNA, and microRNA contribute to cell-to-cell communication and cell-to-environment regulation, however, their biological functions are not yet fully understood. In this report, exosomes in the glioblastoma cell line, U-87MG, were isolated and the proteome was investigated. In addition, exosome proteome changes in U-87MG cells exposed to a low temperature were investigated to elucidate whether the exosome proteome could respond to an external stimulus...
December 6, 2016: Biology
https://www.readbyqxmd.com/read/27923459/micrornas-in-lipid-metabolism-and-atherosclerosis
#20
REVIEW
Hector Giral, Adelheid Kratzer, Ulf Landmesser
Numerous studies have examined the role of microRNAs (miRNAs) in cell homeostasis and cardiovascular disease and have markedly improved our understanding of RNA biology in general and the potential role of miRNAs in atherosclerosis. In atherosclerosis, several miRNAs, such as miR-33a,b, miR-92a, miR-126 and others, have been identified that are relevant mediators of pathological processes, including regulation of cholesterol and lipid biosynthesis, lipoprotein metabolism and cholesterol efflux, but also immune responses, endothelial cell biology and vascular function...
October 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
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