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https://www.readbyqxmd.com/read/28732364/a-novel-heterozygous-germline-deletion-in-msh2-gene-in-a-five-generation-chinese-family-with-lynch-syndrome
#1
Bin Wu, Wuyang Ji, Shengran Liang, Chao Ling, Yan You, Lai Xu, Min-Er Zhong, Yi Xiao, Hui-Zhong Qiu, Jun-Yang Lu, Santasree Banerjee
Lynch syndrome (LS) is one of the most common familial forms of colorectal cancer predisposing syndrome with an autosomal dominant mode of inheritance. LS is caused by the germline mutations in DNA mismatch repair (MMR) genes including MSH2, MLH1, MSH6and PMS2. Clinically, LS is characterized by high incidence of early-onset colorectal cancer as well as endometrial, small intestinal and urinary tract cancers, usually occur in the third to fourth decade of the life. Here we describe a five generation Chinese family with LS clinically diagnosed according to the Amsterdam II criteria...
July 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732317/cross-lagged-relations-between-motives-and-substance-use-can-use-strengthen-your-motivation-over-time
#2
Christine A Lee, Karen J Derefinko, Heather A Davis, Richard Milich, Donald R Lynam
Motives for substance use have garnered considerable attention due to the strong predictive utility of this construct, both in terms of use and problems associated with use. The current study examined the cross-lagged relations between alcohol use and motives, and marijuana use and motives over three yearly assessment periods in a large sample (N=526, 48% male) of college students. The relations between substance use and motives were assessed at each time point, allowing for the examination of these inter-relations over time...
June 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28732262/attitudes-toward-epilepsy-and-perceptions-of-epilepsy-related-stigma-in-korean-evangelical-christians
#3
Sang-Ahm Lee, Eun-Ju Choi, Ji-Ye Jeon, Joon-Hyun Paek
PURPOSE: The scriptural description of Jesus driving out an evil spirit from a boy with epilepsy supported the idea of the spiritual nature of epilepsy for centuries. Korea has a shorter history of Christianity than the Western world. We determined whether there are differences in attitudes toward epilepsy and perception of epilepsy-related stigma between people with and without belief in evangelical Christianity in Korea. METHODS: Data were collected from evangelical churches and theological colleges...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28732190/comparison-of-the-acc-aha-and-framingham-algorithms-to-assess-cardiovascular-risk-in-hiv-infected-patients
#4
Lauro Ferreira da Silva Pinto Neto, Fernanda Rezende Dias, Flavia Feres Bressan, Carolina Rocio Oliveira Santos
The aim of this study was to compare the predictions of Framingham cardiovascular (CV) risk score (FRS) and the American College of Cardiology/American Heart Association (ACC/AHA) risk score in an HIV outpatient clinic in the city of Vitoria, Espirito Santo, Brazil. In a cross-sectional study 341 HIV infected patients over 40 years old consecutively recruited were interviewed. Cohen's kappa coefficient was used to assess agreement between the two algorithms. 61.3% were stratified as low risk by Framingham score, compared with 54% by ACC/AHA score (Spearman correlation 0...
July 18, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28732152/secukinumab-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-a-review-of-the-literature
#5
M Abrouk, J Gandy, M Nakamura, K Lee, M Brodsky, R Singh, H Zhu, B Farahnik, T Bhutani, J Koo
While there are several commercially available treatment options for psoriasis and psoriatic arthritis, there remains a large number of individuals who are refractory to current modalities. In the recent past, there has been increasing evidence that interleukin (IL)-17 plays a vital role in the pathophysiology of psoriasis. Preclinical, phase II, and phase III studies of secukinumab (Cosentyx®) targeting IL-17 and its receptor have thus far proved to be promising. We reviewed the results of phase II and phase III clinical trials for secukinumab in the treatment of psoriasis and psoriatic arthritis...
July 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28732119/association-between-pm2-5-and-pm2-5-constituents-and-preterm-delivery-in-california-2000-2006
#6
Rupa Basu, Dharshani Pearson, Keita Ebisu, Brian Malig
BACKGROUND: Particulate matter (PM) has been documented to contribute to preterm delivery. However, few studies have investigated the relationships between individual constituents of fine PM (PM2.5 ) and preterm delivery, and factors that may modify their associations. METHODS: In this study, we examined the associations between several prenatal exposure metrics to PM2.5 and 23 constituents of PM2.5 and preterm delivery in California from 2000 to 2006. In a retrospective cohort study including 231 637 births, we conducted logistic regression analyses adjusting for maternal, infant, temporal, geographic, and neighbourhood characteristics...
July 21, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28732104/reciprocal-feedback-between-self-concept-and-goal-pursuit-in-daily-life
#7
Alexander E Wong, Robin R Vallacher
OBJECTIVE: We hypothesized that self-knowledge and goal-perseverance are mutually reinforcing because of the roles of self-knowledge in directing goal pursuit, and of goal pursuit in structuring the self-concept. METHOD: To test this hypothesis, we used a daily diary design with 97 college-aged participants for 40 days to assess whether daily self-concept clarity and grit predict one another's next day levels. Data were analyzed using multilevel cross-lagged panel modeling...
July 21, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28731952/open-colectomies-of-shorter-operative-time-do-not-result-in-improved-outcomes-compared-with-prolonged-laparoscopic-operations
#8
Sara L Zettervall, Ivy N Haskins, Sarah E Deery, Richard L Amdur, Paul P Lin, Khashayar Vaziri
BACKGROUND: Laparoscopic colectomies are associated with reduced perioperative morbidity and mortality compared with open surgery. Nevertheless, many surgeons continue to utilize an open surgical approach due to the perceived benefits of shorter operative times. This study aims to compare the outcomes of laparoscopic versus open colectomies of equal or shorter operative duration. METHODS: All patients undergoing elective laparoscopic or open colectomy in the American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP) were identified from the years 2005 through 2012...
July 20, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28731886/collegiate-student-athletes-with-history-of-adhd-or-academic-difficulties-are-more-likely-to-produce-an-invalid-protocol-on-baseline-impact-testing
#9
Lisa Manderino, John Gunstad
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) and other academically-relevant diagnoses have been suggested as modifiers of neurocognitive testing in sport-related concussion, such as Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). These preexisting conditions may suppress ImPACT scores to the extent that they are indistinguishable from low scores because of poor effort. The present study hypothesized that student athletes with history of ADHD or academic difficulties produce lower ImPACT composite scores and are more likely to produce invalid protocols than those without such conditions...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28731611/energy-drink-consumption-is-associated-with-reduced-sleep-quality-among-college-students-a-cross-sectional-study
#10
Mo'ez Al-Islam E Faris, Haitham Jahrami, Marwa M Al-Hilali, Noor J Chehyber, Sara O Ali, Sara D Shahda, Reyad S Obaid
AIM: Intake of caffeinated energy drinks has significantly increased, specifically among young adults and adolescents. College students are prone to developing unhealthy eating habits and dependence on stimulants, which puts them at a greater risk of sleep problems. This study aims to investigate the prevalence of caffeinated energy drink consumption and its association with sleep quality in college students. METHODS: A sample of 919 randomly selected adults (237 males and 682 females) from various colleges at the University of Sharjah/United Arab Emirates participated in this cross-sectional study...
July 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731560/food-insecure-student-clients-of-a-university-based-food-bank-have-compromised-health-dietary-intake-and-academic-quality
#11
Jasmine Farahbakhsh, Mahitab Hanbazaza, Geoff D C Ball, Anna P Farmer, Katerina Maximova, Noreen D Willows
AIM: University and college students in wealthy countries may be vulnerable to financial food insecurity. If food insecure students have suboptimal health, their ability to learn and excel in their education could be compromised. This Canadian study examined the relationship of food security status to diet and self-perceived health and academic quality among students receiving emergency food hampers from the Campus Food Bank at University of Alberta. METHODS: A convenience sample of 58 students completed a survey...
February 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731005/preparing-medical-students-with-congenital-colour-vision-deficiency-for-safe-practice
#12
Rajat Dhingra, Jolly Rohatgi, Upreet Dhaliwal
BACKGROUND: Colour vision of candidates is tested in many medical colleges in India at the time of admission to undergraduate courses; however, there are no guidelines, and therefore no counselling, on how students with congenital colour vision deficiency (CCVD) should negotiate the medical course, and how best they can practise safely after graduation. Problems in interpreting coloured signs may lead to misdiagnosis. This study aimed to explore difficulties during clinical work that requires colour discrimination, and to offer suggestions on safe practice based on the findings and a review of the literature...
January 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28730911/important-learning-factors-in-high-and-low-achieving-students-in-undergraduate-biomechanics
#13
ChengTu Hsieh, Duane Knudson
The purpose of the present study was to document crucial factors associated with students' learning of biomechanical concepts, particularly between high- and-low achieving students. Students (N = 113) from three introductory biomechanics classes at two public universities volunteered for the study. Two measures of students' learning were obtained, final course grade and improvement on the Biomechanics Concept Inventory version 3 administered before and after the course. Participants also completed a 15-item questionnaire documenting student learning characteristics, effort, and confidence...
July 21, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28730681/histone-variants-expression-in-peripheral-blood-mononuclear-cells-of-patients-with-rheumatoid-arthritis
#14
Maryam Asadipour, Vahideh Hassan-Zadeh, Naheed Aryaeian, Farhad Shahram, Mahdi Mahmoudi
AIM: The purpose of the present study was to analyze the expression of four histone variants, implicated in the regulation of gene expression, in peripheral blood mononuclear cell (PBMC) samples of patients with rheumatoid arthritis and healthy controls. METHOD: We analyzed the expression of three genes encoding histone variants H3.3, H2A.Z, macroH2A1.1 and macroH2A1.2 in PBMC samples of 50 patients with RA, diagnosed according to American College of Rheumatology (ACR) criteria, and 51 matched healthy controls using SYBR green real-time polymerase chain reaction...
July 21, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28730640/2016-updated-thai-rheumatism-association-recommendations-for-the-use-of-biologic-and-targeted-synthetic-disease-modifying-anti-rheumatic-drugs-in-patients-with-rheumatoid-arthritis
#15
Worawit Louthrenoo, Nuntana Kasitanon, Wanruchada Katchamart, Duangkamol Aiewruengsurat, Parawee Chevaisrakul, Praveena Chiowchanwisawakit, Pornchai Dechanuwong, Punchong Hanvivadhanakul, Ajanee Mahakkanukrauh, Siriporn Manavathongchai, Chayawee Muangchan, Pongthorn Narongroeknawin, Veerapong Phumethum, Boonjing Siripaitoon, Anawat Suesuwan, Siraphop Suwannaroj, Parichat Uea-Areewongsa, Sittichai Ukritchon, Paijit Asavatanabodee, Ajchara Koolvisoot, Ratanavadee Nanagara, Kitti Totemchokchyakarn, Kanokrut Nuntirooj, Tasanee Kitumnuaypong
AIM: In June 2015, the Thai Rheumatism Association (TRA) approved an update of its recommendation for the use of biologic disease-modifying anti-rheumatic drugs (bDMARDs) and targeted synthetic (tsDMARD) in the treatment of rheumatoid arthritis (RA) to cover those currently available in Thailand (etanercept, infliximab, golimumab, rituximab, tocilizumab, abatacept and tofacitinib). METHOD: A search of the literature was performed between January 2000 and June 2015...
July 21, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28729815/symposium-report-an-evidence-based-approach-to-ibs-and-cic-applying-new-advances-to-daily-practice-a-review-of-an-adjunct-clinical-symposium-of-the-american-college-of-gastroenterology-meeting-october-16-2016-%C3%A2-las-vegas-nevada
#16
William D Chey
Many nonpharmacologic and pharmacologic therapies are available to manage irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC). The American College of Gastroenterology (ACG) regularly publishes reviews on IBS and CIC therapies. The most recent of these reviews was published by the ACG Task Force on the Management of Functional Bowel Disorders in 2014. The key objective of this review was to evaluate the efficacy of therapies for IBS or CIC compared with placebo or no treatment in randomized controlled trials...
February 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28729187/poor-employment-conditions-adversely-affect-mental-health-outcomes-among-surgical-trainees
#17
Jasmina Kevric, Nathan Papa, Marlon Perera, Prem Rashid, Sumeet Toshniwal
BACKGROUND: Poor mental health in junior clinicians is prevalent and may lead to poor productivity and significant medical errors. We aimed to provide contemporary data on the mental health of surgical trainees and identify risk factors relating to poorer mental health outcomes. METHODS: A detailed questionnaire was developed comprising questions based on the 36-item short-form health survey (SF-36) and Physical Activity Questionnaire. Each of the questionnaires has proven validity and reliability in the clinical context...
July 17, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28729168/ecological-momentary-assessment-of-pain-fatigue-depressive-and-cognitive-symptoms-reveals-significant-daily-variability-in-multiple-sclerosis
#18
Anna L Kratz, Susan L Murphy, Tiffany J Braley
OBJECTIVE: To describe the daily variability and patterns of pain, fatigue, depressed mood, and cognitive function in persons with multiple sclerosis (MS). DESIGN: Repeated-measures observational study of seven consecutive days of home monitoring, including ecological momentary assessment (EMA) of symptoms. Multilevel mixed models were used to analyze data. SETTING: General community. PARTICIPANTS: Ambulatory adults (N=107) with MS recruited through [Masked] and surrounding community...
July 17, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28729146/construction-of-nutrition-literacy-indicators-for-college-students-in-taiwan-a-delphi-consensus-study
#19
Li-Ling Liao, I-Ju Lai
OBJECTIVE: To use the Delphi process to select nutrition literacy (NL) indicators for Taiwan college students. DESIGN: Initial formulation of 8 principal indicators and 77 subindicators, followed by a 2-round Delphi survey and final selection of indicators. PARTICIPANTS: A total of 28 nutrition experts selected through snowball sampling; 100% response rate. MAIN OUTCOME MEASURES: An expert panel scored and ranked NL themes and indicators for relevance, representativeness, and importance...
July 17, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28729108/no-214-guidelines-for-the-management-of-pregnancy-at-41-0-to-42-0-weeks
#20
Martina Delaney, Anne Roggensack
OBJECTIVE: To provide evidence-based guidelines for the management of pregnancy at 41+0 to 42+0 weeks. OUTCOMES: Reduction of perinatal mortality associated with Caesarean section at 41+0 to 42+0 weeks of pregnancy. EVIDENCE: The Medline database, the Cochrane Library, and the American College of Obstetricians and Gynecologists and the Royal College of Obstetricians and Gynecologists, were searched for English language articles published between 1966 and March 2007, using the following key words: prolonged pregnancy, post-term pregnancy, and postdates pregnancy...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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