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https://www.readbyqxmd.com/read/28817481/incorporating-dynamic-assessment-of-fluid-responsiveness-into-goal-directed-therapy-a-systematic-review-and-meta-analysis
#1
Joseph M Bednarczyk, Jason A Fridfinnson, Anand Kumar, Laurie Blanchard, Rasheda Rabbani, Dean Bell, Duane Funk, Alexis F Turgeon, Ahmed M Abou-Setta, Ryan Zarychanski
OBJECTIVE: Dynamic tests of fluid responsiveness have been developed and investigated in clinical trials of goal-directed therapy. The impact of this approach on clinically relevant outcomes is unknown. We performed a systematic review and meta-analysis to evaluate whether fluid therapy guided by dynamic assessment of fluid responsiveness compared with standard care improves clinically relevant outcomes in adults admitted to the ICU. DATA SOURCES: Randomized controlled trials from MEDLINE, EMBASE, CENTRAL, clinicaltrials...
September 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28815403/overexpression-of-topoisomerase-2-alpha-confers-a-poor-prognosis-in-pancreatic-adenocarcinoma-identified-by-co-expression-analysis
#2
Zhou Zhou, Shi Liu, Meng Zhang, Rui Zhou, Jing Liu, Ying Chang, Qiu Zhao
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of human cancer-related death in the developed countries. Its progression and prognosis are influenced by a complex network of gene interactions. AIMS: The purpose of this study is to explore key genes associated with pancreatic ductal adenocarcinoma and to predict the possible mechanisms. METHODS: A weighted gene co-expression network was constructed to identify gene modules associated with the progression of PDAC...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28814547/annual-summary-of-vital-statistics-2013-2014
#3
Sherry L Murphy, T J Mathews, Joyce A Martin, Cynthia S Minkovitz, Donna M Strobino
The number of births in the United States increased by 1% between 2013 and 2014, to a total of 3 988 076. The general fertility rate rose 1% to 62.9 births per 1000 women. The total fertility rate also rose 0.3% in 2014, to 1862.5 births per 1000 women. The teenage birth rate fell to another historic low in 2014, 24.2 births per 1000 women. The percentage of all births to unmarried women declined to 40.2% in 2014, from 40.6% in 2013. In 2014, the cesarean delivery rate declined to 32.2% from 32.7% in 2013...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28814398/plasma-lipidomic-profiles-and-cardiovascular-events-in-a-randomized-intervention-trial-with-the-mediterranean-diet
#4
Estefanía Toledo, Dong D Wang, Miguel Ruiz-Canela López, Clary B Clish, Cristina Razquin, Yan Zheng, Marta Guasch-Ferré, Adela Hruby, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, Emilio Ros, José Lapetra, Montserrat Fito, Fernando Aros, Luis Serra-Majem, Liming Liang, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD).Objective: We evaluated the associations between 1) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3) 1-y changes in lipid species and subsequent CVD.Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28808642/burden-of-disease-attributable-to-vitamin-a-deficiency-in-iranian-population-aged-less-than-five-years-findings-from-the-global-burden-of-disease-study-2010
#5
Maryam Bahreynian, Mostafa Qorbani, Shohreh Naderimagham, Sara Nejatinamini, Asal Ataie-Jafari, Farshad Sharifi, Fahad Saqib, Alireza Khajavi, Morteza Mansourian, Ali Asghar Ahmadishokouh, Hamid Asayesh, Omid Safari, Roya Kelishadi
BACKGROUND: Vitamin A deficiency (VAD) is considered as one of the most serious public health concerns in developing countriesand the leading cause of mortality in under-five-year-old children.A large number of young children and pregnant women especially in low-income, non-industrialized communities are more susceptible to VAD. This study aims to report the burden of disease (BOD) attributable to VAD in Iranian population aged less than 5 years by using data of the Global Burden of Disease (GBD) study 2010...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28803369/volume-balance-and-intradialytic-ultrafiltration-rate-in-the-hemodialysis-patient
#6
REVIEW
Jason A Chou, Kamyar Kalantar-Zadeh
PURPOSE OF REVIEW: Volume management in hemodialysis patients is often challenging. Assessing volume status and deciding how much fluid to remove during hemodialysis, the so-called ultrafiltration rate (UFR), has remained a conundrum. RECENT FINDINGS: To date there is no objective assessment tool to determine the needed UFR during each hemodialysis session. Higher volume overload or higher UFR is associated with poor outcomes including worse mortality and unfavorable clinical outcomes...
August 12, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28801414/transformation-of-mortality-in-a-remote-australian-aboriginal-community-a-retrospective-observational-study
#7
Wendy E Hoy, Susan Anne Mott, Beverly June McLeod
OBJECTIVES: To describe trends in ages and causes of death in a remote-living Australian Aboriginal group over a recent 50-year period. DESIGN: A retrospective observational study, from 1960 to 2010, of deaths and people starting dialysis, using data from local clinic, parish, dialysis and birthweight registers. SETTING: A remote island community in the Top End of Australia's Northern Territory, where a Catholic mission was established in 1911...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799164/preconception-care-for-diabetic-women-for-improving-maternal-and-infant-health
#8
REVIEW
Joanna Tieu, Philippa Middleton, Caroline A Crowther, Emily Shepherd
BACKGROUND: Infants born to mothers with pre-existing type 1 or type 2 diabetes mellitus are at greater risk of congenital anomalies, perinatal mortality and significant morbidity in the short and long term. Pregnant women with pre-existing diabetes are at greater risk of perinatal morbidity and diabetic complications. The relationship between glycaemic control and health outcomes for both mothers and infants indicates the potential for preconception care for these women to be of benefit...
August 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28797514/trends-in-international-asthma-mortality-analysis-of-data-from-the-who-mortality-database-from-46-countries-1993-2012
#9
Stefan Ebmeier, Darmiga Thayabaran, Irene Braithwaite, Clément Bénamara, Mark Weatherall, Richard Beasley
BACKGROUND: International time trends in asthma mortality have been strongly affected by changes in management and in particular drug treatments. However, little is known about how asthma mortality has changed over the past decade. In this study, we assessed these international trends. METHODS: We collated age-standardised country-specific asthma mortality rates in the 5-34 year age group from the online WHO Mortality Database for 46 countries. To be included in the analysis, we specified that a country must have 10 years of complete data in the WHO Mortality Database between 1993 and 2012...
August 7, 2017: Lancet
https://www.readbyqxmd.com/read/28794626/folic-acid-functionalized-polyethylenimine-superparamagnetic-iron-oxide-nanoparticles-as-theranostic-agents-for-magnetic-resonance-imaging-and-pd-l1-sirna-delivery-for-gastric-cancer
#10
Xin Luo, Xia Peng, Jingying Hou, Shuyun Wu, Jun Shen, Lingyun Wang
Programmed death ligand-1 (PD-L1), which is highly expressed in gastric cancers, interacts with programmed death-1 (PD-1) on T cells and is involved in T-cell immune resistance. To increase the therapeutic safety and accuracy of PD-1/PD-L1 blockade, RNA interference through targeted gene delivery was performed in our study. We developed folic acid (FA)- and disulfide (SS)-polyethylene glycol (PEG)-conjugated polyethylenimine (PEI) complexed with superparamagnetic iron oxide Fe3O4 nanoparticles (SPIONs) as a siRNA-delivery system for PD-L1 knockdown...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28791722/blood-pressure-and-the-risk-of-chronic-kidney-disease-progression-using-multistate-marginal-structural-models-in-the-cric-study
#11
Alisa J Stephens-Shields, Andrew J Spieker, Amanda Anderson, Paul Drawz, Michael Fischer, Stephen M Sozio, Harold Feldman, Marshall Joffe, Wei Yang, Tom Greene
In patients with chronic kidney disease (CKD), clinical interest often centers on determining treatments and exposures that are causally related to renal progression. Analyses of longitudinal clinical data in this population are often complicated by clinical competing events, such as end-stage renal disease (ESRD) and death, and time-dependent confounding, where patient factors that are predictive of later exposures and outcomes are affected by past exposures. We developed multistate marginal structural models (MS-MSMs) to assess the effect of time-varying systolic blood pressure on disease progression in subjects with CKD...
August 9, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28791290/placental-malaria-a-new-insight-into-the-pathophysiology
#12
REVIEW
Lalita Sharma, Geeta Shukla
Malaria in pregnancy poses a great health risk to mother and her fetus and results into complications, such as abortion, still birth, intra uterine growth retardation, and low birth weight. The heavy infiltration of Plasmodium falciparum-infected RBCs in the intervillous spaces of placenta seems to be responsible for all the complications observed. Infected RBCs in the placenta cause an inflammatory environment with increase in inflammatory cells and cytokines which is deleterious to the placenta. Increased inflammatory responses in the infected placenta result into oxidative stress that in turn causes oxidative stress-induced placental cell death...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28790895/brain-metal-distribution-and-neuro-inflammatory-profiles-after-chronic-vanadium-administration-and-withdrawal-in-mice
#13
Oluwabusayo R Folarin, Amanda M Snyder, Douglas G Peters, Funmilayo Olopade, James R Connor, James O Olopade
Vanadium is a potentially toxic environmental pollutant and induces oxidative damage in biological systems including the central nervous system (CNS). Its deposition in brain tissue may be involved in the pathogenesis of certain neurological disorders which after prolonged exposure can culminate into more severe pathology. Most studies on vanadium neurotoxicity have been done after acute exposure but in reality some populations are exposed for a lifetime. This work was designed to ascertain neurodegenerative consequences of chronic vanadium administration and to investigate the progressive changes in the brain after withdrawal from vanadium treatment...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28789792/change-in-%C3%AE-2-agonist-use-after-severe-life-events-in-adults-with-asthma-a-population-based-cohort-study-life-events-and-bronchodilator-usage-among-adults-with-asthma
#14
Raija Lietzén, Pekka Virtanen, Mika Kivimäki, Jyrki Korkeila, Sakari Suominen, Lauri Sillanmäki, Markku Koskenvuo, Jussi Vahtera
OBJECTIVE: This prospective, population-based cohort study of 1102 Finnish adults with asthma, examined whether exposure to stressful life events is associated with the intensity of usage of inhaled short-acting β2-agonists. METHODS: Survey data was collected by two postal questionnaires. Baseline characteristics were obtained in 1998 and data on 19 specific stressful events (e.g. death of a child or spouse or divorce) within the six preceding months in 2003. Exposure to life events was indicated by a sum score weighted by mean severity of the events...
September 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28780390/a-12-year-experience-with-tracheostomy-for-neonates-and-infants-in-northern-taiwan-indications-hospital-courses-and-long-term-outcomes
#15
Chia-Huei Chen, Jui-Hsing Chang, Chyong-Hsin Hsu, Nan-Chang Chiu, Chun-Chin Peng, Wai-Tim Jim, Hung-Yang Chang, Kuo-Sheng Lee
BACKGROUND: Tracheostomy is a valuable procedure in infants and neonates with chronic respiratory failure or severe airway obstruction. The aim of this study is to identify the indication, hospital course, and long-term outcome in a cohort of infants who required tracheostomy in a neonatal and pediatric tertiary care center in northern Taiwan. METHODS: Medical records of infants, who underwent tracheostomy between January 2002 and December 2013, were retrospectively reviewed...
July 24, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28766519/-the-possibilities-for-diagnostics-of-prescription-of-death-coming-based-on-the-changes-in-the-lumbar-intervertebral-disks-the-comparison-of-the-morphological-immunohistochemical-and-topographical-findings
#16
V A Byval'tsev, I A Stepanov, A V Semenov, D V Perfil'ev, E G Belykh, L A Bardonova, S B Nikiforov, N P Sudakov, I V Bespyatykh, S L Antipina
The objective of the present study was the comprehensive analysis of the postmortem changes in the lumbar intervertebral disks within different periods after death. A total of seven vertebromotor segments were distinguished in the lumbosacral region of the vertebral column based on the examination of 7 corpses. All these segments were divided into three groups in accordance with the prescription of death coming as follows: up to 12 hours (group 1), between 12 and 24 hours (group 2), and between 24 and 36 hours (group 3) after death...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28763449/identification-of-factors-associated-with-stillbirth-in-the-indian-state-of-bihar-using-verbal-autopsy-a-population-based-study
#17
Rakhi Dandona, G Anil Kumar, Amit Kumar, Priyanka Singh, Sibin George, Mohammad Akbar, Lalit Dandona
BACKGROUND: India was estimated to have the largest numbers of stillbirths globally in 2015, and the Indian government has adopted a target of <10 stillbirths per 1,000 births by 2030 through the India Newborn Action Plan (INAP). The objective of this study was to use verbal autopsy interviews to examine factors associated with stillbirth in the Indian state of Bihar and make recommendations for the INAP to better inform the setting of priorities and actions to reduce stillbirths. METHODS AND FINDINGS: Verbal autopsy interviews were conducted for deaths including stillbirths that occurred from January 2011 to March 2014 in a sample of 109,689 households (87...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28762313/adoptive-immunotherapy-for-b-cell-malignancies-using-cd19-targeted-chimeric-antigen-receptor-t-cells-a-systematic-review-of-efficacy-and-safety
#18
Lu Hao, Tongtong Li, Lung-Ji Chang, Xiaochuan Chen
BACKGROUND: Adoptive infusion of chimeric antigen receptor transduced T-cells (CAR-T) is a powerful tool of immunotherapy for hematological malignancies, as evidenced by recently published and unpublished clinical results. OBJECTIVE: In this report, we performed a meta-analysis to evaluate the efficacy and side effects of CAR-T on relapsed B-cell malignancies, including leukemia and lymphoma. METHODS: Clinical studies investigating efficacy and safety of CAR-T in acute and chronic lymphocytic leukemia and lymphoma were identified by searching PubMed and EMBASE...
August 1, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28761681/smoking-intensity-and-duration-is-associated-with-cardiac-structure-and-function-the-echocardiographic-study-of-hispanics-latinos
#19
J Adam Leigh, Robert C Kaplan, Katrina Swett, Pelbreton Balfour, Mayank M Kansal, Gregory A Talavera, Krista Perreira, Michael J Blaha, Emelia J Benjamin, Rosemarie Robertson, Aruni Bhartnagar, Carlos J Rodriguez
OBJECTIVE: Cardiovascular disease is the leading cause of death in smokers and this relationship is complicated by the multiplicity of cardiovascular effects of smoking. However, the relationship between intensity and duration of cigarette smoking and echocardiographic measures of right and left ventricular structure and function has been poorly studied. METHODS: We examined ECHO-SOL (Echocardiographic Study of Hispanics/Latinos) participants, a subset of the Hispanic Community Health Study/Study of Latinos...
2017: Open Heart
https://www.readbyqxmd.com/read/28761655/changes-in-risk-factors-and-their-contribution-to-reduction-of-mortality-risk-following-gastric-bypass-surgery-among-obese-individuals-with-type-2-diabetes-a-nationwide-matched-observational-cohort-study
#20
Vasileios Liakopoulos, Stefan Franzén, Ann-Marie Svensson, Björn Zethelius, Johan Ottosson, Ingmar Näslund, Soffia Gudbjörnsdottir, Björn Eliasson
OBJECTIVE: We recently showed that Roux-en-Y gastric bypass (RYGB) reduces risks of mortality, cardiovascular death and myocardial infarction in obese individuals compared with matched patients with diabetes mellitus (DM). We have examined changes in risk factors after RYGB, with the aim of explaining these effects. RESEARCH DESIGN AND METHODS: We matched (1:1) 6132 RYGB patients with DM reported to the Scandinavian Obesity Surgery Register with patients who had not undergone RYGB, based on sex, age, body mass index (BMI) and time, and assessed effects 2007-2014...
2017: BMJ Open Diabetes Research & Care
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