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https://www.readbyqxmd.com/read/28535450/the-global-burden-of-fatal-self-poisoning-with-pesticides-2006-15-systematic-review
#1
REVIEW
Emma J Mew, Prianka Padmanathan, Flemming Konradsen, Michael Eddleston, Shu-Sen Chang, Michael R Phillips, David Gunnell
BACKGROUND: Agricultural pesticide poisoning is a major contributor to the global burden of suicide. Over the last decade there has been a marked decrease in the incidence of suicide worldwide. It is unclear whether pesticide poisoning still plays a significant role in the global incidence of suicide. METHODS: WHO method-specific suicide data were supplemented by a systematic review of the literature between 2006 and 2015, including searches of thirteen electronic databases and Google, citation searching and a review of reference lists and personal collections...
May 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28530525/cost-effectiveness-of-nivolumab-ipilimumab-combination-therapy-compared-with-monotherapy-for-first-line-treatment-of-metastatic-melanoma-in-the-united-states
#2
Anna Oh, Dang M Tran, Leann C McDowell, Dor Keyvani, Jay Andrew Barcelon, Oscar Merino, Leslie Wilson
BACKGROUND: The approval of new immunotherapies has dramatically changed the treatment landscape of metastatic melanoma. These survival gains come with trade-offs in side effects and costs, as well as important considerations for third-party payer systems, physicians, and patients. OBJECTIVE: To develop a Markov model to determine the cost-effectiveness of nivolumab, ipilimumab, and nivolumab-ipilimumab combination as firstline therapy in metastatic melanoma, while accounting for differential effectiveness in programmed death-ligand 1 (PD-L1) positive and negative patients...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28529640/lung-cancer-targeting-peptides-with-multi-subtype-indication-for-combinational-drug-delivery-and-molecular-imaging
#3
Yi-Hsuan Chi, Jong-Kai Hsiao, Ming-Huang Lin, Chen Chang, Chun-Hsin Lan, Han-Chung Wu
Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (LCC) or small cell lung cancer (SCLC). Therefore, we aimed to identify targeting peptides with diagnostic and therapeutic utility that possess broad subtype specificity for SCLC and non-small cell lung cancer (NSCLC)...
2017: Theranostics
https://www.readbyqxmd.com/read/28527533/global-regional-and-national-burden-of-cardiovascular-diseases-for-10-causes-1990-to-2015
#4
Gregory A Roth, Catherine Johnson, Amanuel Abajobir, Foad Abd-Allah, Semaw Ferede Abera, Gebre Abyu, Muktar Ahmed, Baran Aksut, Tahiya Alam, Khurshid Alam, François Alla, Nelson Alvis-Guzman, Stephen Amrock, Hossein Ansari, Johan Ärnlöv, Hamid Asayesh, Tesfay Mehari Atey, Leticia Avila-Burgos, Ashish Awasthi, Amitava Banerjee, Aleksandra Barac, Till Bärnighausen, Lars Barregard, Neeraj Bedi, Ezra Belay Ketema, Derrick Bennett, Gebremedhin Berhe, Zulfiqar Bhutta, Shimelash Bitew, Jonathan Carapetis, Juan Jesus Carrero, Deborah Carvalho Malta, Carlos Andres Castañeda-Orjuela, Jacqueline Castillo-Rivas, Ferrán Catalá-López, Jee-Young Choi, Hanne Christensen, Massimo Cirillo, Leslie Cooper, Michael Criqui, David Cundiff, Albertino Damasceno, Lalit Dandona, Rakhi Dandona, Kairat Davletov, Samath Dharmaratne, Prabhakaran Dorairaj, Manisha Dubey, Rebecca Ehrenkranz, Maysaa El Sayed Zaki, Emerito Jose A Faraon, Alireza Esteghamati, Talha Farid, Maryam Farvid, Valery Feigin, Eric L Ding, Gerry Fowkes, Tsegaye Gebrehiwot, Richard Gillum, Audra Gold, Philimon Gona, Rajeev Gupta, Tesfa Dejenie Habtewold, Nima Hafezi-Nejad, Tesfaye Hailu, Gessessew Bugssa Hailu, Graeme Hankey, Hamid Yimam Hassen, Kalkidan Hassen Abate, Rasmus Havmoeller, Simon I Hay, Masako Horino, Peter J Hotez, Kathryn Jacobsen, Spencer James, Mehdi Javanbakht, Panniyammakal Jeemon, Denny John, Jost Jonas, Yogeshwar Kalkonde, Chante Karimkhani, Amir Kasaeian, Yousef Khader, Abdur Khan, Young-Ho Khang, Sahil Khera, Abdullah T Khoja, Jagdish Khubchandani, Daniel Kim, Dhaval Kolte, Soewarta Kosen, Kristopher J Krohn, G Anil Kumar, Gene Kwan, Dharmesh Kumar Lal, Anders Larsson, Shai Linn, Alan Lopez, Paulo A Lotufo, Hassan Magdy Abd El Razek, Reza Malekzadeh, Mohsen Mazidi, Toni Meier, Kidanu Gebremariam Meles, George Mensah, Atte Meretoja, Haftay Mezgebe, Ted Miller, Erkin Mirrakhimov, Shafiu Mohammed, Andrew E Moran, Kamarul Imran Musa, Jagat Narula, Bruce Neal, Frida Ngalesoni, Grant Nguyen, Carla Makhlouf Obermeyer, Mayowa Owolabi, George Patton, João Pedro, Dima Qato, Mostafa Qorbani, Kazem Rahimi, Rajesh Kumar Rai, Salman Rawaf, Antônio Ribeiro, Saeid Safiri, Joshua A Salomon, Itamar Santos, Milena Santric Milicevic, Benn Sartorius, Aletta Schutte, Sadaf Sepanlou, Masood Ali Shaikh, Min-Jeong Shin, Mehdi Shishehbor, Hirbo Shore, Diego Augusto Santos Silva, Eugene Sobngwi, Saverio Stranges, Soumya Swaminathan, Rafael Tabarés-Seisdedos, Niguse Tadele Atnafu, Fisaha Tesfay, J S Thakur, Amanda Thrift, Roman Topor-Madry, Thomas Truelsen, Stefanos Tyrovolas, Kingsley Nnanna Ukwaja, Olalekan Uthman, Tommi Vasankari, Vasiliy Vlassov, Stein Emil Vollset, Tolassa Wakayo, David Watkins, Robert Weintraub, Andrea Werdecker, Ronny Westerman, Charles Shey Wiysonge, Charles Wolfe, Abdulhalik Workicho, Gelin Xu, Yuichiro Yano, Paul Yip, Naohiro Yonemoto, Mustafa Younis, Chuanhua Yu, Theo Vos, Mohsen Naghavi, Christopher Murray
BACKGROUND: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. OBJECTIVES: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. METHODS: CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries...
May 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28526336/activation-of-na-h-exchanger-other-than-formation-of-transmembrane-pore-underlies-the-cytotoxicity-of-nematocyst-venom-from-chrysaora-helvola-brandt-jellyfish
#5
Lanlan Fan, Jun Luo, Xiaoyong Li, Ming Chen, Wei Shu, Xiaosheng Qu
We previously reported unexpected apoptosis-like cell death induced by nematocyst venom (NV) from Chrysaora helvola Brandt (C. helvola) jellyfish. To assess whether the pore formation mechanism underlay the action of NV, the change in cell membrane permeability was studied in both chicken erythrocytes and human CNE-2 cells. Initially, paradoxical results were derived from osmoprotectant protection assays. Polyethylene glycol (PEG)2000, which completely inhibited the NV induced hemolysis, failed to protect CNE-2 cells...
May 17, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28526182/pharmacologic-management-of-type-2-diabetes-mellitus-available-therapies
#6
James Thrasher
Choices for the treatment of type 2 diabetes mellitus (T2DM) have multiplied as our understanding of the underlying pathophysiologic defects has evolved. Treatment should target multiple defects in T2DM and follow a patient-centered approach that considers factors beyond glycemic control, including cardiovascular risk reduction. The American Association of Clinical Endocrinologists/American College of Endocrinology and the American Diabetes Association recommend an initial approach consisting of lifestyle changes and monotherapy, preferably with metformin...
May 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28506211/interstitial-pneumonia-pattern-on-day-7-chest-radiograph-predicts-bronchopulmonary-dysplasia-in-preterm-infants
#7
Hye-Rim Kim, Ji Young Kim, Bo La Yun, Byoungkook Lee, Chang Won Choi, Beyong Il Kim
BACKGROUND: Early identification of infants at higher risk of developing bronchopulmonary dysplasia (BPD) may enable a targeted approach to reduce BPD. We aimed to evaluate the hypothesis that the interstitial pneumonia pattern on the day 7 chest radiograph predicts BPD or death before 36 weeks postmenstrual age (PMA). METHODS: A retrospective cohort study was performed on 336 preterm infants (birth weight < 1500 g and gestational age < 32 postmenstrual weeks) who were admitted to a single tertiary academic center between January 2008 and December 2014...
May 15, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28501974/proteolytic-activities-in-cortex-of-apical-parts-of-vicia-faba-ssp-minor-seedling-roots-during-kinetin-induced-programmed-cell-death
#8
Andrzej Kaźmierczak, Magdalena Doniak, Anita Kunikowska
Programmed cell death (PCD) is a crucial process in plant development. In this paper, proteolytically related aspects of kinetin-induced PCD in cortex cells of Vicia faba ssp. minor seedlings were examined using morphological, fluorometric, spectrophotometric, and fluorescence microscopic analyses. Cell viability estimation after 46 μM kinetin treatment of seedling roots showed that the number of dying cortex cells increased with treatment duration, reaching maximum after 72 h. Weight of the apical root segments increased with time and was about 2...
May 13, 2017: Protoplasma
https://www.readbyqxmd.com/read/28499988/melanocortin-neurons-multiple-routes-to-regulation-of-metabolism
#9
REVIEW
Wen-Jie Shen, Ting Yao, Xingxing Kong, Kevin W Williams, Tiemin Liu
The burden of disability, premature death, escalating health care costs and lost economic productivity due to obesity and its associated complications including hypertension, stroke, cardiovascular disease and type 2 diabetes is staggering [1, 2]. A better understanding of metabolic homeostatic pathways will provide us with insights into the biological mechanisms of obesity and how to fundamentally address this epidemic [3-6]. In mammals, energy balance is maintained via a homeostatic system involving both peripheral and central melanocortin systems; changes in body weight reflect an unbalance of the energetic state [7-9]...
May 9, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28494681/acute-and-sub-chronic-toxicity-of-cajanus-cajan-leaf-extracts
#10
Rong Tang, Ru-Hua Tian, Jia-Zhong Cai, Jun-Hui Wu, Xiao-Ling Shen, Ying-Jie Hu
CONTEXT: The leaves of Cajanus cajan (L.) Millsp. (Fabaceae) have diverse bioactivities, but little safety data are reported. OBJECTIVE: This study examines the toxicological profiles of C. cajan leaf extracts. MATERIALS AND METHODS: The leaves were extracted by water or 90% ethanol to obtain water or ethanol extract (WEC or EEC). EEC was suspended in water and successively fractionated into dichloroform and n-butanol extracts (DEC and BEC)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28494385/l-leucine-dietary-supplementation-modulates-muscle-protein-degradation-and-increases-pro-inflammatory-cytokines-in-tumour-bearing-rats
#11
Bread Cruz, André Oliveira, Maria Cristina Cintra Gomes-Marcondes
Cancer cachexia is characterised by involuntary weight loss associated with systemic inflammation and metabolic changes. Studies aimed at maintaining lean body mass in cachectic tumour-bearing hosts have made important contributions reducing the number of deaths and improving the quality of life. In recent years, leucine has demonstrated effective action in maintaining lean body mass by decreasing muscle protein degradation. Currently, there is a growing need to understand how leucine stimulates protein synthesis and acts protectively in a cachectic organism...
May 8, 2017: Cytokine
https://www.readbyqxmd.com/read/28490226/intensity-of-hydration-changes-the-role-of-renin-angiotensin-aldosterone-system-blockers-in-contrast-induced-nephropathy-risk-after-coronary-catheterisation-in-patients-with-chronic-kidney-disease
#12
Xiao-Sheng Guo, Deng-Xuan Wu, Wei-Jie Bei, Hua-Long Li, Kun Wang, Ying-Ling Zhou, Chong-Yang Duan, Shi-Qun Chen, Dan Lian, Li-Wen Li, Yong Liu, Ning Tan, Ji-Yan Chen
OBJECTIVE: This study evaluated the potential effect of hydration intensity on the role of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) on contrast-induced nephropathy in patients with renal insufficiency. METHODS: All eligible patients were included and stratified according to hydration intensity defined as saline hydration volume to body weight tertiles: <10.21 mL/kg, 10.21 to <17.86 mL/kg, and ⩾17.86 mL/kg. RESULTS: In total, 84 (6...
April 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28487012/distinct-effects-of-short-and-long-term-type-1-diabetes-to-the-placental-extracellular-matrix-and-fetal-development-in-mice
#13
Juliane C Sanches, Rodolfo R Favaro, Fernanda C Barrence, Estela Bevilacqua, Zuleica B Fortes, Telma M T Zorn
PURPOSE: We have previously shown that the development of complications in the early pregnant decidua and myometrium in mice correlates with diabetes progression. In the current study, we investigated the influence of diabetes progression on the placental extracellular matrix (ECM) and on fetal development at the end of pregnancy. METHODS: Alloxan-induced type 1 diabetic female mice were bred either 30-50 days after diabetes induction (D) or 90-110D. Fetal and placental weights were registered at the 19th day of pregnancy together with analysis of gene expression, deposition and turnover of the placental ECM...
May 2017: Placenta
https://www.readbyqxmd.com/read/28479925/inhibition-of-cardiac-hypertrophy-effects-in-d-galactose-induced-senescent-hearts-by-alpinate-oxyphyllae-fructus-treatment
#14
Yung-Ming Chang, Hen-Hong Chang, Hung-Jen Lin, Chin-Chuan Tsai, Chuan-Te Tsai, Hsin-Nung Chang, Shu-Luan Lin, Vijaya PadmaViswanadha, Ray-Jade Chen, Chih-Yang Huang
Aging is a complex physiological phenomenon accelerated by ROS accumulation, with multisystem decline and increasing vulnerability to degenerative diseases and death. Cardiac hypertrophy is a key pathophysiological component that accompanies the aging process. Alpinate Oxyphyllae Fructus (Alpinia oxyphylla MIQ, AOF) is a traditional Chinese medicine, which provides cardioprotective activity against aging, hypertension, and cerebrovascular disorders. In this study, we found the protective effect of AOF against cardiac hypertrophy in D-galactose-induced aging rat model...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28479167/trajectory-of-congestion-metrics-by-ejection-fraction-in%C3%A2-patients-with-acute-heart-failure-from-the-heart-failure%C3%A2-network
#15
Andrew P Ambrosy, Ankeet S Bhatt, Dianne Gallup, Kevin J Anstrom, Javed Butler, Adam D DeVore, G Michael Felker, Marat Fudim, Stephen J Greene, Adrian F Hernandez, Jacob P Kelly, Marc D Samsky, Robert J Mentz
Differences in the clinical course of congestion by underlying ejection fraction (EF) have not been well-characterized in acute heart failure (AHF). A post hoc analysis was performed using pooled data from the Diuretic Optimization Strategies Evaluation in Acute Heart Failure, Cardiorenal Rescue Study in Acute Decompensated Heart Failure, and Renal Optimization Strategies Evaluation in Acute Heart Failure trials. All patients were admitted for a primary diagnosis of AHF. Patients were grouped as reduced EF ≤40%, borderline 40% < EF < 50%, or preserved EF ≥50%...
April 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28478771/evaluation-of-the-long-term-safety-and-tolerability-of-cariprazine-in-patients-with-schizophrenia-results-from-a-1-year-open-label-study
#16
Andrew J Cutler, Suresh Durgam, Yao Wang, Raffaele Migliore, Kaifeng Lu, István Laszlovszky, György Németh
OBJECTIVE: Cariprazine, a dopamine D3/D2 partial agonist atypical antipsychotic with preferential binding to D3 receptors, is approved for the treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder. The efficacy and safety of cariprazine was established in three randomized, double-blind, placebo-controlled, 6-week trials in patients with acute exacerbation of schizophrenia. This 53-week study evaluated the long-term safety and tolerability of cariprazine in patients with schizophrenia...
May 8, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28476513/animal-models-of-cachexia-and-sarcopenia-in-chronic-illness-cardiac-function-body-composition-changes-and-therapeutic-results
#17
REVIEW
Junichi Ishida, Masakazu Saitoh, Wolfram Doehner, Stephan von Haehling, Markus Anker, Stefan D Anker, Jochen Springer
Cachexia is defined as a complex metabolic syndrome associated with underlying illness that is characterized by the loss of body weight consisting of muscle and fat mass wasting. Sarcopenia is defined as the ageing related loss of muscle mass in health and disease that may not have an effect on body weight. As millions of patients are in cachectic or sarcopenic states, both conditions contribute to high numbers to death worldwide. A number of treatments have been proposed for cachexia and sarcopenia, but these are either in the preclinical stage or in clinical trials and hence not available to the general population...
April 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28475712/surgical-management-of-aortopulmonary-window-24-years-of-experience-and-lessons-learned
#18
Deepak Gowda, Trushar Gajjar, Jinaga Nageswar Rao, Praveen Chavali, Aaditya Sirohi, Naveen Pandarinathan, Neelam Desai
OBJECTIVES: Aortopulmonary window represents 0.2-0.3% of all congenital heart lesions. Progressive pulmonary arterial hypertension and its consequences are more common with this anomaly. The purpose of this study was to share 24 years of surgical experience in managing a spectrum of 55 cases of aortopulmonary window, followed up to 17 years in a single institution. METHODS: : This retrospective study was done from November 1991 to November 2015 of 55 patients with aortopulmonary window who underwent successful surgical repair...
May 5, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28473056/protein-and-exercise-in-the-prevention-of-sarcopenia-and-aging
#19
REVIEW
Manal A Naseeb, Stella L Volpe
Aging is associated with a progressive decline in skeletal muscle mass and strength. The decline, known as sarcopenia, could lead to physical disability, poor quality of life, and death. In addition, the older population usually experiences age-related muscle changes that affect muscle mass, muscular strength, and functional abilities. The purpose of this review is to describe the role of protein and exercise in slowing the progression of sarcopenia. It will also discuss whether age-related changes can be attenuated by dietary protein and exercise in the older population...
April 2017: Nutrition Research
https://www.readbyqxmd.com/read/28461334/deficiency-in-the-manganese-efflux-transporter-slc30a10-induces-severe-hypothyroidism-in-mice
#20
Steven Hutchens, Chunyi Liu, Thomas Jursa, William Shawlot, Beth K Chaffee, Weiling Yin, Andrea C Gore, Michael Aschner, Donald R Smith, Somshuvra Mukhopadhyay
Manganese (Mn) is an essential metal that becomes toxic at elevated levels. Loss-of-function mutations in SLC30A10, a cell surface-localized Mn efflux transporter, cause a heritable Mn metabolism disorder resulting in elevated Mn levels and parkinsonian-like movement deficits. The underlying disease mechanisms are unclear; therefore, treatment is challenging. To understand the consequences of loss of SLC30A10 function at the organism level, we generated Slc30a10 knockout mice. During early development, knockouts were indistinguishable from controls...
May 1, 2017: Journal of Biological Chemistry
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