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https://www.readbyqxmd.com/read/29348067/physiological-response-and-transcription-profiling-analysis-reveals-the-role-of-h2s-in-alleviating-excess-nitrate-stress-tolerance-in-tomato-roots
#1
Zhaolai Guo, Yuanlin Liang, Jinping Yan, En Yang, Kunzhi Li, Huini Xu
Soil secondary salinization caused by excess nitrate addition is one of the major obstacles in greenhouse vegetable production. Excess nitrate inhibited the growth of tomato plants, while application of 100 μM H2S donor NaHS efficiently increased the plant height, fresh and dry weight of shoot and root, root length, endogenous H2S contents and L-cysteine desulfhydrases activities. NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX)...
January 11, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29345251/cancer-associated-cachexia
#2
REVIEW
Vickie E Baracos, Lisa Martin, Murray Korc, Denis C Guttridge, Kenneth C H Fearon
Cancer-associated cachexia is a disorder characterized by loss of body weight with specific losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination of reduced food intake and metabolic changes, including elevated energy expenditure, excess catabolism and inflammation. Cachexia is highly associated with cancers of the pancreas, oesophagus, stomach, lung, liver and bowel; this group of malignancies is responsible for half of all cancer deaths worldwide. Cachexia involves diverse mediators derived from the cancer cells and cells within the tumour microenvironment, including inflammatory and immune cells...
January 18, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29337281/clinical-significance-of-early-fluid-and-weight-change-during-acute-heart-failure-hospitalization
#3
John D Groarke, Susanna R Stevens, Robert J Mentz, Lauren B Cooper, Justin M Vader, Omar F AbouEzzeddine, Justin L Grodin, Emer Joyce, Kevin J Anstrom, G Michael Felker, Margaret M Redfield, Lynne Warner Stevenson, Anuradha Lala
AIMS: To explore the association of changes in weight and fluid during treatment for acute heart failure (AHF) with clinical endpoints. METHODS AND RESULTS: Weight and net fluid changes recorded at 72-96 hours in 708 AHF patients enrolled in DOSE-HF, CARRESS-HF or ROSE-AHF, were compared to freedom from congestion at 72-96 hours and a composite end point of death, re-hospitalization, and unplanned hospital visit at 60 days. Weight loss was concordant with net fluid loss in 55%, discordant and less than expected for fluid loss in 34%, and paradoxically discordant or more than expected for fluid loss in 11% of patients...
January 11, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29331677/identification-of-potential-mr-derived-biomarkers-for-tumor-tissue-response-to-177lu-octreotate-therapy-in-an-animal-model-of-small-intestine-neuroendocrine-tumor
#4
Mikael Montelius, Johan Spetz, Oscar Jalnefjord, Evelin Berger, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
Magnetic resonance (MR) methods enable noninvasive, regional tumor therapy response assessment, but associations between MR parameters, underlying biology, and therapeutic effects must be investigated. The aim of this study was to investigate response assessment efficacy and biological associations of MR parameters in a neuroendocrine tumor (NET) model subjected to radionuclide treatment. Twenty-one mice with NETs received 177Lu-octreotate at day 0. MR experiments (day -1, 1, 3, 8, and 13) included T2-weighted, dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) and relaxation measurements (T1/T2*)...
January 10, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29325437/the-prevalence-and-burden-of-mental-and-substance-use-disorders-in-australia-findings-from-the-global-burden-of-disease-study-2015
#5
Liliana G Ciobanu, Alize J Ferrari, Holly E Erskine, Damian F Santomauro, Fiona J Charlson, Janni Leung, Azmeraw T Amare, Andrew T Olagunju, Harvey A Whiteford, Bernhard T Baune
OBJECTIVES: Timely and accurate assessments of disease burden are essential for developing effective national health policies. We used the Global Burden of Disease Study 2015 to examine burden due to mental and substance use disorders in Australia. METHODS: For each of the 20 mental and substance use disorders included in Global Burden of Disease Study 2015, systematic reviews of epidemiological data were conducted, and data modelled using a Bayesian meta-regression tool to produce prevalence estimates by age, sex, geography and year...
January 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29324598/adoption-of-minimally-invasive-surgery-and-decrease-in-surgical-morbidity-for-endometrial-cancer-treatment-in-the-united-states
#6
Jvan Casarin, Francesco Multinu, Daniel S Ubl, Sean C Dowdy, William A Cliby, Gretchen E Glaser, Kristina A Butler, Fabio Ghezzi, Elizabeth B Habermann, Andrea Mariani
OBJECTIVE: To assess how the widespread adoption of minimally invasive surgery in the United States is associated with changes in 30-day morbidity and mortality in endometrial cancer treatment. METHODS: In this retrospective cohort study, the American College of Surgeons' National Surgical Quality Improvement Project database for 2008-2014 was reviewed for patients who had undergone surgery for endometrial cancer according to their primary Current Procedural Terminology (CPT) codes...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29321684/leptin-and-the-maintenance-of-elevated-body-weight
#7
REVIEW
Warren W Pan, Martin G Myers
Obesity represents the single most important risk factor for early disability and death in developed societies, and the incidence of obesity remains at staggering levels. CNS systems that modulate energy intake and expenditure in response to changes in body energy stores serve to maintain constant body adiposity; the adipocyte-derived hormone leptin and its receptor (LEPR) represent crucial regulators of these systems. As in the case of insulin resistance, a variety of mechanisms (including feedback inhibition, inflammation, gliosis and endoplasmic reticulum stress) have been proposed to interfere with leptin action and impede the systems that control body energy homeostasis to promote or maintain obesity, although the relative importance and contribution of each of these remain unclear...
January 11, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29321641/antiphospholipid-syndrome
#8
REVIEW
Karen Schreiber, Savino Sciascia, Philip G de Groot, Katrien Devreese, Soren Jacobsen, Guillermo Ruiz-Irastroza, Jane E Salmon, Yehuda Shoenfeld, Ora Shovman, Beverley J Hunt
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein 1 antibodies. APS can present with a variety of clinical phenotypes, including thrombosis in the veins, arteries and microvasculature as well as obstetrical complications. The pathophysiological hallmark is thrombosis, but other factors such as complement activation might be important. Prevention of thrombotic manifestations associated with APS includes lifestyle changes and, in individuals at high risk, low-dose aspirin...
January 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29319158/effect-of-restriction-vegan-diet-s-on-muscle-mass-oxidative-status-and-myocytes-differentiation-a-pilot-study
#9
D Vanacore, G Messina, S Lama, G Bitti, P Ambrosio, G C Tenore, A Messina, V Monda, S Zappavigna, M Boccellino, E Novellino, M Monda, P Stiuso
This study was conceived to evaluate the effects of three different diets on body composition, metabolic parameters and serum oxidative status. We enrolled three groups of healthy men (omnivores, vegetarians and vegans) with similar age, weight and BMI and we observed a significant decrease in muscle mass index and lean body mass in vegan compared to vegetarian and omnivore groups, and higher serum homocysteine levels in vegetarians and vegans compared to omnivores. We studied whether serum from omnivore, vegetarian and vegan subjects affected oxidative stress, growth and differentiation of both cardiomyoblast cell line H9c2 and H-H9c2 (H9c2 treated with H2 O2 to induce oxidative damage)...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29318511/midazolam-efficacy-against-acute-hydrogen-sulfide-induced-mortality-and-neurotoxicity
#10
Poojya Anantharam, Dong-Suk Kim, Elizabeth M Whitley, Belinda Mahama, Paula Imerman, Piyush Padhi, Wilson K Rumbeiha
Hydrogen sulfide (H2S) is a colorless, highly neurotoxic gas. It is not only an occupational and environmental hazard but also of concern to the Department of Homeland Security for potential nefarious use. Acute high-dose H2S exposure causes death, while survivors may develop neurological sequelae. Currently, there is no suitable antidote for treatment of acute H2S-induced neurotoxicity. Midazolam (MDZ), an anti-convulsant drug recommended for treatment of nerve agent intoxications, could also be of value in treating acute H2S intoxication...
January 9, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29304403/targeting-death-receptors-for-drug-resistant-cancer-therapy-codelivery-of-ptrail-and-monensin-using-dual-targeting-and-stimuli-responsive-self-assembling-nanocomposites
#11
Fan Xu, Huihai Zhong, Ya Chang, Dongdong Li, Hongyue Jin, Meng Zhang, Huiyuan Wang, Chen Jiang, Youqing Shen, Yongzhuo Huang
Chemoresistance remains a formidable hurdle against cancer therapy. Seeking for novel therapy strategies is an urgent need for those who no longer benefit from chemotherapy. Chemoresistance is usually associated with the dysfunction of intrinsic apoptosis. Targeting extrinsic apoptosis via TRAIL signaling and the death receptors could be a potential solution to treat chemoresistant cancer. A highly biocompatible nano system for codelivery of the TRAIL DNA and the death receptor sensitizer monensin was developed, in which low-molecular-weight PEI (LMW-PEI) was crosslinked by the sulfhydryl cyclodextrin via disulfide bonds, and then bound with DNA, thus forming the bioreducible polyplex cores...
December 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/29301522/the-low-indexes-of-metabolism-intervention-trial-limit-design-and-baseline-data-of-a-randomized-controlled-clinical-trial-to-evaluate-how-alerting-primary-care-teams-to-low-metabolic-values-could-affect-the-health-of-patients-aged-75-or-older
#12
Nir Tsabar, Yan Press, Johanna Rotman, Bracha Klein, Yonatan Grossman, Maya Vainshtein-Tal, Sophia Eilat-Tsanani
BACKGROUND: Too-low body mass index (BMI), HbA1c% or cholesterol levels predicts poor survival. This study investigates whether e-mails about these low values, improve health of people older than 75 years. METHODS: LIMIT - an open label randomized trial - compares usual care to the addition of an e-mail which alerts the family physicians and nurses to low metabolic indexes of a specific patient and advises on nutritional and medical changes. PARTICIPANTS: Clalit Health Services (CHS) patients in the Northern and Southern Districts, aged ≥75 years with any of the following inclusion criteria: a...
January 5, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29289705/molecular-imaging-of-tumor-photoimmunotherapy-evidence-of-photosensitized-tumor-necrosis-and-hemodynamic-changes
#13
Shun Kishimoto, Nobu Oshima, Kazutoshi Yamamoto, Jeeva Munasinghe, Jan Henrik Ardenkjaer-Larsen, James B Mitchell, Peter L Choyke, Murali C Krishna
Near-infrared photoimmunotherapy (NIR PIT) employs the photoabsorbing dye IR700 conjugated to antibodies specific for cell surface epidermal growth factor receptor (EGFR). NIR PIT has shown highly selective cytotoxicity in vitro and in vivo. Cell necrosis is thought to be the main mode of cytotoxicity based mainly on in vitro studies. To better understand the acute effects of NIR PIT, molecular imaging studies were performed to assess its cellular and vascular effects. In addition to in vitro studies for cytotoxicity of NIR PIT, the in vivo tumoricidal effects and hemodynamic changes induced by NIR PIT were evaluated by 13C MRI using hyperpolarized [1,4-13C2] fumarate, R2* mapping from T2*-weighted MRI, and photoacoustic imaging...
December 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29285670/a-3-variable-prognostic-score-3-ps-for-overall-survival-prediction-in-metastatic-castration-resistant-prostate-cancer-treated-with-223radium-dichloride
#14
Viviana Frantellizzi, Alessio Farcomeni, Giulia Anna Follacchio, Massimiliano Pacilio, Rosanna Pellegrini, Roberto Pani, Giuseppe De Vincentis
OBJECTIVE: In mCRPC patients treated with 223Ra, a major issue is the validation of reliable prognostic and predictive biomarkers to maximize clinical benefit and minimize toxicities and costs. Bearing in mind how changes in tALP did not meet statistical requirements as surrogate marker for survival, aim of this single-center retrospective study was to characterize the prognostic and predictive role of baseline clinical variables associated with overall survival in patients receiving 223Ra treatment...
December 28, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29282143/azithromycin-versus-placebo-for-the-treatment-of-hiv-associated-chronic-lung-disease-in-children-and-adolescents-breathe-trial-study-protocol-for-a-randomised-controlled-trial
#15
Carmen Gonzalez-Martinez, Katharina Kranzer, Grace McHugh, Elizabeth L Corbett, Hilda Mujuru, Mark P Nicol, Sarah Rowland-Jones, Andrea M Rehman, Tore J Gutteberg, Trond Flaegstad, Jon O Odland, Rashida A Ferrand
BACKGROUND: Human immunodeficiency virus (HIV)-related chronic lung disease (CLD) among children is associated with substantial morbidity, despite antiretroviral therapy. This may be a consequence of repeated respiratory tract infections and/or dysregulated immune activation that accompanies HIV infection. Macrolides have anti-inflammatory and antimicrobial properties, and we hypothesised that azithromycin would reduce decline in lung function and morbidity through preventing respiratory tract infections and controlling systemic inflammation...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29278686/lqfm030-reduced-ehrlich-ascites-tumor-cell-proliferation-and-vegf-levels
#16
Mariana Flavia da Mota, Flávio Silva de Carvalho, Renato Ivan de Ávila, Paulo Henrique Marcelino de Ávila, Alane Pereira Cortez, Ricardo Menegatti, José Ricardo Sabino, Thais Rosa Marques Dos Santos, Sandro Antônio Gomes, Luiz Carlos da Cunha, Marize Campos Valadares
AIMS: This study reports the biological properties of LQFM030 in vivo, a molecular simplification of the compound nutlin-1. MAIN METHODS: Ehrlich ascites tumor (EAT)-bearing mice were treated intraperitoneally with LQFM030 (50, 75 or 150mg/kg) for 10days to determine changes in ascites tumor volume, body weight, cytotoxicity and angiogenesis. Moreover, flow cytometric expression of p53 and p21 proteins and caspase-3/7, -8 and -9 activation were investigated in EAT cells from mice treated...
December 23, 2017: Life Sciences
https://www.readbyqxmd.com/read/29277920/three-dimensional-morphological-analysis-of-the-human-sacroiliac-joint-influences-on-the-degenerative-changes-of-the-auricular-surfaces
#17
Keita Nishi, Toshiyuki Tsurumoto, Keishi Okamoto, Keiko Ogami-Takamura, Takashi Hasegawa, Takefumi Moriuchi, Junya Sakamoto, Joichi Oyamada, Toshio Higashi, Yoshitaka Manabe, Kazunobu Saiki
The sacroiliac joint (SIJ) is responsible for weight transmission between the spine and lower extremity. However, details of the structure and function of the SIJ remain unclear. In a previous study, we devised a method of quantitatively evaluating the level of degeneration of the SIJ using an age estimation procedure for the auricular surface of the ilium. Our results in that study suggested that the degree of degeneration of the joint surface may be associated with the morphology of the auricular surface of the ilium...
December 25, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29275569/-establishment-of-rat-model-with-diabetes-mellitus-and-concomitant-periodontitis-and-the-carotid-artery-lesions-in-the-model-rats
#18
X Y Ren, C Wang, X Liu, H Li, J H Gao, X J Ge
Objectives: To establish SD rat model with type 2 diabetes mellitus (DM) and concomitant chronic periodontitis (CP) and to evaluate the influence of periodontitis on the vascular lesions of type 2 diabetes rats. Methods: Totally 241 clean level SD rats were randomly divided into four groups, group A (normal control, NC, n=27), group B (DM, n=34), group C (CP, n=90) and group D (DM+CP, n=90). The rats of DM group were fed with high-fat and high-sugar diet for 8 to 10 weeks, and then were multiply injected with small dose streptozotocin under the condition of ice bath...
December 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29250207/dynamic-prediction-of-renal-failure-using-longitudinal-biomarkers-in-a-cohort-study-of-chronic-kidney-disease
#19
Liang Li, Sheng Luo, Bo Hu, Tom Greene
In longitudinal studies, prognostic biomarkers are often measured longitudinally. It is of both scientific and clinical interest to predict the risk of clinical events, such as disease progression or death, using these longitudinal biomarkers as well as other time-dependent and time-independent information about the patient. The prediction is dynamic in the sense that it can be made at any time during the follow-up, adapting to the changing at-risk population and incorporating the most recent longitudinal data...
December 2017: Statistics in Biosciences
https://www.readbyqxmd.com/read/29248876/associations-between-adjuvant-radiotherapy-and-different-causes-of-death-in-a-german-breast-cancer-cohort
#20
Nadia Obi, Christine Eulenburg, Petra Seibold, Ursula Eilber, Kathrin Thöne, Sabine Behrens, Jenny Chang-Claude, Dieter Flesch-Janys
BACKGROUND: Studies of cohorts of breast cancer (BC) patients diagnosed before 1990 showed radiotherapy (RT) to be associated with increased cardiovascular (CVD) and lung cancer mortality many years after diagnosis. In the late 1990s, improvements in RT planning techniques reduced radiation doses to normal tissues. Recent studies did not consistently report higher RT-related mortality for CVD and second cancers. Aim of the study was to analyze specific causes of death after 3D-conformal RT in a recent BC cohort...
December 14, 2017: Breast: Official Journal of the European Society of Mastology
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