Mehmet Kanbay, Constance Xhaard, Edith Le Floch, Claire Dandine-Roulland, Nicolas Girerd, João Pedro Ferreira, Jean-Marc Boivin, Sandra Wagner, Delphine Bacq-Daian, Jean-François Deleuze, Faiez Zannad, Patrick Rossignol
Background Hyperuricemia is associated with poor cardiovascular outcomes, although it is uncertain whether this relationship is causal in nature. This study aimed to: (1) assess the heritability of serum uric acid (SUA) levels, (2) conduct a genome-wide association study on SUA levels, and (3) investigate the association between certain single-nucleotide polymorphisms and target organ damage. Methods and Results The STANISLAS (Suivi Temporaire Annuel Non-Invasif de la Santé des Lorrains Assurés Sociaux) study cohort is a single-center longitudinal cohort recruited between 1993 and 1995 (visit 1), with a last visit (visit 4 [V4]) performed ≈20 years apart...
May 3, 2022: Journal of the American Heart Association