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Uric acid AND pulse wave velocity

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https://www.readbyqxmd.com/read/27754036/os-13-02-association-between-uric-acid-metabolic-variables-and-arterial-stiffness-in-the-early-phase-of-hypertension
#1
Francesca Saladini, Elisabetta Benetti, Claudio Fania, Lucio Mos, Raffaella Garbelotto, Andrea Mazzer, Edoardo Casiglia, Paolo Palatini
OBJECTIVE: High serum uric acid (SUA) is often associated with the metabolic syndrome and is a risk factor for cardiovascular disease. Whether high SUA is associated with arterial stiffness in the early stage of hypertension is not well known. DESIGN AND METHOD: We addressed this issue in 340 non-diabetic subjects from the HARVEST study (73% males) with a mean age of 31 ± 8 years and a mean blood pressure (BP) of 145 ± 11/92 ± 6 mmHg. Patients were divided into SUA tertiles (T1: 1...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753924/os-04-08-the-relationship-between-childhood-risk-factors-and-long-term-arterial-stiffness-a-26-year-follow-up-study
#2
Jianjun Mu, Chao Chu, Dan Wang, Tongshuai Guo, Yang Wang, Fan Yang
OBJECTIVE: To explore the relationship between childhood risk factors and long-term arterial stiffness. DESIGN AND METHOD: A baseline survey was carried out in 4623 school children aged 6-15 years in rural areas of Hanzhong city, Shaanxi in 1987. According to three measurements of systolic blood pressure (SBP) in 1987,1989 and 1992, high blood pressure group (HBP group) was defined as SBP ≥ 75 percentile at same age and gender, with SBP < 50 percentile as normal blood pressure group (NBP group)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27676633/relationship-between-equol-producer-status-and-metabolic-parameters-in-743-japanese-women-equol-producer-status-is-associated-with-antiatherosclerotic-conditions-in-women-around-menopause-and-early-postmenopause
#3
Remi Yoshikata, Khin Z Myint, Hiroaki Ohta
OBJECTIVE: Equol, an active metabolite possessing estrogen-like activity, is produced by the action of intestinal flora on soy isoflavones. There is an increasing evidence regarding its efficacy in the relief of menopausal symptoms, suppression of decreased bone mineral density, and lipid profile improvement. Only those with equol-producing capacity, however, seem to benefit. Thus, we examined the relationship between equol producer status and parameters associated with lifestyle-related diseases in women from their 20s to 80s...
September 26, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27643317/os-04-08-the-relationship-between-childhood-risk-factors-and-long-term-arterial-stiffness-a-26-year-follow-up-study
#4
Jianjun Mu, Chao Chu, Dan Wang, Tongshuai Guo, Yang Wang, Fan Yang
OBJECTIVE: To explore the relationship between childhood risk factors and long-term arterial stiffness. DESIGN AND METHOD: A baseline survey was carried out in 4623 school children aged 6-15 years in rural areas of Hanzhong city, Shaanxi in 1987. According to three measurements of systolic blood pressure (SBP) in 1987,1989 and 1992, high blood pressure group (HBP group) was defined as SBP ≥ 75 percentile at same age and gender, with SBP < 50 percentile as normal blood pressure group (NBP group)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642954/os-13-02-association-between-uric-acid-metabolic-variables-and-arterial-stiffness-in-the-early-phase-of-hypertension
#5
Francesca Saladini, Elisabetta Benetti, Claudio Fania, Lucio Mos, Raffaella Garbelotto, Andrea Mazzer, Edoardo Casiglia, Paolo Palatini
OBJECTIVE: High serum uric acid (SUA) is often associated with the metabolic syndrome and is a risk factor for cardiovascular disease. Whether high SUA is associated with arterial stiffness in the early stage of hypertension is not well known. DESIGN AND METHOD: We addressed this issue in 340 non-diabetic subjects from the HARVEST study (73% males) with a mean age of 31 ± 8 years and a mean blood pressure (BP) of 145 ± 11/92 ± 6 mmHg. Patients were divided into SUA tertiles (T1: 1...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508719/-op-1b-03-identification-of-a-cut-off-level-of-uric-acid-associated-with-vascular-stiffness-in-a-general-population
#6
A Di Leva, M Koretzky, S Obregon, P Pardini, G Maccallini, M Haehnel, E Huguet, F Botto, A Scuteri, P M Nilsson, C Kotliar
OBJECTIVE: The role of uric acid (UA) in the development of hypertension and atherosclerosis has been extensively studied. In regard to vascular stiffness, UA has demonstrated an independent association with age, gender, obesity, blood pressure and renal function. However, research has focused on the relationship between UA elevation and high blood pressure or atherosclerosis in hypertensive and renal failure patients. Recent data from the Framingham cohort, showed that this association persists in the general population...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27498274/high-serum-uric-acid-is-associated-to-poorly-controlled-blood-pressure-and-higher-arterial-stiffness-in-hypertensive-subjects
#7
Arrigo F G Cicero, Martina Rosticci, Federica Fogacci, Elisa Grandi, Sergio D'Addato, Claudio Borghi
INTRODUCTION: Serum uric acid (SUA) has been associated to incident hypertension and increased risk of cardiovascular diseases. MATERIALS AND METHODS: Among the 2191 subjects enrolled during the last population survey of the Brisighella Heart Study, we identified 146 new cases of arterial hypertension and 394 treated but uncontrolled hypertensive patients with different levels of SUA. Their hemodynamic characteristics have been compared with those of age- and sex-matched normotensive (N...
August 3, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27371101/correlations-of-nonalcoholic-fatty-liver-disease-and-serum-uric-acid-with-subclinical-atherosclerosis-in-obese-chinese-adults
#8
Yongwen Liu, Changqin Liu, Xiulin Shi, Mingzhu Lin, Bing Yan, Xin Zeng, Ningning Chen, Shuhua Lu, Suhuan Liu, Shuyu Yang, Xuejun Li, Zhibin Li
BACKGROUND: Existing evidence about the associations of nonalcoholic fatty liver disease (NAFLD) and serum uric acid (SUA) with subclinical atherosclerosis is controversial. The present study aimed to examine the associations of NAFLD and SUA with subclinical atherosclerosis. METHODS: A cross-sectional study of 1,354 obese adults underwent hepatic ultrasonography scanning and arteriosclerosis detection was conducted in Xiamen, China. Subclinical atherosclerosis indices were brachial-ankle pulse wave velocity (ba-PWV) and ankle-brachial index (ABI)...
July 1, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27295214/potential-role-of-vegetarianism-on-nutritional-and-cardiovascular-status-in-taiwanese-dialysis-patients-a-case-control-study
#9
Shih-Hsiang Ou, Mei-Yin Chen, Chien-Wei Huang, Nai-Ching Chen, Chien-Hsing Wu, Chih-Yang Hsu, Kang-Ju Chou, Po-Tsang Lee, Hua-Chang Fang, Chien-Liang Chen
BACKGROUND & OBJECTIVES: Cardiovascular disease remains the most common cause of death for patients on chronic dialysis. End stage renal disease patients undergoing dialysis imposed to reduce phosphorus intake, which likely contributes to development of vegetarian diet behaviors. Vegetarian diets are often lower in protein content, in contradiction to the recommendation that a high protein diet is followed by patients undergoing dialysis. The purpose of the study was to investigate the effects of a vegetarian diet on the nutritional and cardiovascular status of dialysis patients...
2016: PloS One
https://www.readbyqxmd.com/read/27247108/association-between-uric-acid-and-renal-function-in-hypertensive-patients-which-role-for-systemic-vascular-involvement
#10
Giulio Geraci, Giuseppe Mulè, Massimiliano Morreale, Claudia Cusumano, Antonella Castiglia, Francesca Gervasi, Francesco D'Ignoto, Manuela Mogavero, Calogero Geraci, Santina Cottone
The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without chronic kidney disease and divided population into tertiles of SUA based on sex-specific cutoff values...
July 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27239926/-peripheral-vessel-wall-changes-in-hypertensive-patients-with-gout
#11
B A Shelest
AIM: To investigate the specific features of arterial wall endothelial dysfunction and stiffness in patients with hypertension concurrent with gout. SUBJECTS AND METHODS: A total of 54 patients were examined and divided into 2 groups. A study group consisted of 33 hypertensive patients with gout and a comparison group included 21 hypertensive patients without hyperuricemia. The patients did not differ in blood pressure (BP) readings. Uric acid was determined by the reaction with tungstophosphoric solution AT (Reagent, Dnepropetrovsk, Ukraine)...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27181363/clinical-predictive-factors-in-diabetic-kidney-disease-progression
#12
Nicholas J Radcliffe, Jas-Mine Seah, Michele Clarke, Richard J MacIsaac, George Jerums, Elif I Ekinci
Diabetic Kidney Disease (DKD) represents a major component of the health burden associated with type 1 (T1DM) and type 2 (T2DM) diabetes. Recent advances have produced an explosion of 'novel' assay-based risk markers for DKD, though clinical use remains restricted. While many patients with progressive DKD follow a classical albuminuria-based pathway, non-albuminuric DKD progression is now well recognised. In general, the following clinical and biochemical characteristics have been associated with progressive DKD in both T1DM and T2DM: increased HbA1c, systolic BP, albuminuria grade, early glomerular filtraiton rate (GFR) decline, duration of diabetes, age (including pubertal onset), and serum uric acid; presence of concomitant microvascular complications; positive family history...
April 25, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27160127/age-sex-and-glucose-dependent-correlation-of-plasma-soluble-vascular-adhesion-protein-1-concentration-with-cardiovascular-risk-factors-and-subclinical-atherosclerosis
#13
D-W Chen, Y Jin, R-M Zhao, L-J Long, J Zhang, C-L Han, A Roivainen, J Knuuti, S Jalkanen, J-C Wang
OBJECTIVE: Soluble vascular adhesion protein-1 (sVAP-1) may act as a biomarker for atherosclerosis and cardiovascular diseases. The associations of sVAP-1 concentration with cardiovascular risk factors and subclinical atherosclerosis at the population level have not been reported. PATIENTS AND METHODS: This cross-sectional study included 834 asymptomatic subjects (49.1 ± 9.3 years). sVAP-1 was measured by enzyme-linked immunosorbent assay. Subclinical atherosclerosis was assessed by brachial-ankle pulse wave velocity (baPWV) and carotid intima-media thickness (CIMT)...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27070159/-role-of-assessment-of-arterial-wall-stiffness-in-predicting-carotid-artery-atherosclerosis-in-patients-with-abdominal-obesity
#14
O Yu Druzhilova, M A Druzhilov, V V Otmakhov, E S Andreeva, T Yu Kuznetsova
AIM: To estimate the possibility of using arterial wall stiffness (AWS) parameters as predictors for carotid artery atherosclerotic plaques (CAAPs) in patients with abdominal obesity (AO). MATERIALS AND METHODS: A total of 132 patients (72% men; mean age, 45.0±5.3 years) with normal blood pressure (BP) and AO, and no cardiovascular diseases (CVD) at a SCORE risk of <5% were examined. The investigators analyzed lipid composition of blood, its levels of glucose, uric acid, and creatinine, by calculating glomerular filtration rate and performed 24-hour BP monitoring, by estimating AWS parameters, and triplex scanning of the brachiocephalic arteries...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26995876/-the-first-step-aiming-at-the-prevention-of-hypertension-and-atherosclerosis-identification-of-individuals-at-high-risk-of-hypertension
#15
REVIEW
Yasuaki Dohi
Hypertension is an established risk factor of cardiovascular morbidity and mortality. Although antihypertensive treatment reduces the risk of cardiovascular disease, it is impossible to identify all hypertensive subjects among the general population and to manage them in medical facilities considering the huge number of people with hypertension. Furthermore, more than half of cardiovascular events occur in individuals with mild hypertension or in those with a lower blood pressure. In this context, primary prevention of hypertension is an important public health problem...
November 2015: Rinsho Byori. the Japanese Journal of Clinical Pathology
https://www.readbyqxmd.com/read/26635913/serum-superoxide-dismutase-is-associated-with-vascular-structure-and-function-in-hypertensive-and-diabetic-patients
#16
Manuel A Gómez-Marcos, Ana M Blázquez-Medela, Luis Gamella-Pozuelo, José I Recio-Rodriguez, Luis García-Ortiz, Carlos Martínez-Salgado
Oxidative stress is associated with cardiac and vascular defects leading to hypertension and atherosclerosis, being superoxide dismutase (SOD) one of the main intracellular antioxidant defence mechanisms. Although several parameters of vascular function and structure have a predictive value for cardiovascular morbidity-mortality in hypertensive patients, there are no studies on the involvement of SOD serum levels with these vascular parameters. Thus, we assessed if SOD serum levels are correlated with parameters of vascular function and structure and with cardiovascular risk in hypertensive and type 2 diabetic patients...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26425403/diabetes-complications-in-childhood-diabetes-new-biomarkers-and-technologies
#17
Petter Bjornstad, David M Maahs
A major challenge in preventing vascular complications in diabetes is the inability to identify high-risk patients at an early stage, emphasizing the importance of discovering new risk factors, technologies and therapeutic targets to reduce the development and progression of complications. Promising biomarkers which may improve risk stratification and serve as therapeutic targets, include: uric acid, insulin sensitivity, copeptin, SGLT-2 and Klotho/FGF-23. Non-invasive measures of macrovasuclar disease in youth, include: 1) pulse wave velocity to examine arterial stiffness; 2) carotid intima-media thickness to evaluate arterial thickness; 3) cardiac MRI to investigate cardiac function and structure...
June 1, 2015: Current Pediatrics Reports
https://www.readbyqxmd.com/read/26415727/association-between-self-reported-snoring-and-arterial-stiffness-data-from-the-brisighella-heart-study
#18
Arrigo F G Cicero, Martino Morbini, Riccardo Urso, Martina Rosticci, Angelo Parini, Elisa Grandi, Sergio D'Addato, Claudio Borghi
The correlation of both obstructive sleep apnoea syndrome (OSAS) and snoring with cardiovascular risk is well known, but its investigation is complex and not suitable for studying large cohorts of subjects. Thus, we prospectively evaluated 1476 non-pharmacologically treated subjects selected from the last survey of the Brisighella Heart Study. Snoring and sleep apnoea were investigated asking the subjects if they were aware of snoring during the night, and if this was associated with episodes of apnoea. A full set of clinical and laboratory parameters were evaluated, while augmentation index (AIx), and pulse wave velocity (PWV) were recorded with the Vicorder(®) apparatus...
February 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/26386864/factors-influencing-the-relationship-between-atrial-fibrillation-and-artery-stiffness-in-elderly-chinese-patients-with-hypertension
#19
Di Shi, Qingtao Meng, Xiaoyan Zhou, Longxin Li, Kai Liu, Sen He, Si Wang, Xiaoping Chen
BACKGROUND AND AIMS: Atrial fibrillation (AF) is often accompanied by vascular dysfunction in the elderly. The influencing factors in the development of AF are unclear. The aim of this study was to identify links between arterial stiffness and AF to provide new directions for the prevention of AF. METHODS: We recruited 132 patients with both hypertension and AF (78 with paroxysmal AF and 84 with persistent AF) and 136 hypertensive patients. Questionnaires, physical examinations, and laboratory tests were conducted using standard protocols...
August 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/26359174/metabolic-syndrome-is-associated-with-decreased-circulating-endothelial-progenitor-cells-and-increased-arterial-stiffness-in-systemic-lupus-erythematosus
#20
R Castejon, C Jimenez-Ortiz, S Rosado, P Tutor-Ureta, S Mellor-Pita, M Yebra-Bango
OBJECTIVES: Metabolic syndrome (MetS) is highly prevalent in patients with systemic lupus erythematosus (SLE) and it has been associated with increased cardiovascular risk. We examined the contribution of MetS to inflammatory markers, arterial stiffness and circulating endothelial progenitor cells (EPCs) as surrogates of subclinical atherosclerosis. METHODS: Cardiovascular risk factors, SLE-specific factors and peripheral blood EPCs were assessed in 50 female SLE patients...
February 2016: Lupus
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