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https://www.readbyqxmd.com/read/28188070/-inflammation-in-the-perivascular-adipose-tissue-and-atherosclerosis
#1
Nadjiba Hamlat-Khennaf, Samia Neggazi, Hanene Ayari, Patrick Feugier, Giampiero Bricca, Souhila Aouichat-Bouguerra, Michel Beylot
In atherosclerosis studies, there are few data, especially in men, on the biology of perivascular adipose tissue (PVAT) compared to that of other adipose tissue (AT), on amendments in obesity, and its possible role in the development of atherosclerosis. We conducted an ex vivo human study on pericarotid adipose tissue-collected in the immediate vicinity (PVATp) and away from the plate (tapas)-and subcutaneous (SC) neck gathered during surgery from patients suffering from atheromatous carotid disease. In addition, we conducted a study in obese Zucker rats (models of obesity and insulin resistance) and Wistar rats subjected to moderate stress...
February 7, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28118051/the-relationship-between-brown-adipose-tissue-content-in-supraclavicular-fat-depots-and-insulin-sensitivity-in-patients-with-type-2-diabetes-mellitus-and-prediabetes
#2
Ekaterina Koksharova, Dmitry Ustyuzhanin, Yury Philippov, Alexander Mayorov, Marina Shestakova, Merab Shariya, Sergey Ternovoy, Ivan Dedov
BACKGROUND: The evaluation of brown adipose tissue (BAT) and its role in metabolism and obesity remains an important topic in the recent literature. This study evaluated the influence of the BAT triglyceride content measured by proton magnetic resonance (MR) spectroscopy in patients with type 2 diabetes mellitus (DM2) and prediabetes on insulin sensitivity. METHODS: A total of 25 patients with DM2 and prediabetes (45.9 ± 10.1 years old, body mass index [BMI] of 31...
February 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28034591/women-with-polycystic-ovary-syndrome-have-comparable-hip-bone-geometry-to-age-matched-control-women
#3
Laura E McBreairty, Gordon A Zello, Julianne J Gordon, Shani B Serrao, Roger A Pierson, Donna R Chizen, Philip D Chilibeck
Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting women of reproductive age manifesting with polycystic ovaries, menstrual irregularities, hyperandrogenism, hirsutism, and insulin resistance. The oligomenorrhea and amenorrhea characteristic to PCOS are associated with low bone mineral density (BMD); conversely, the hyperandrogenism and hyperinsulinemia may elicit a protective effect on BMD. As bone geometric properties provide additional information about bone strength, the objective of this study was to compare measures of hip geometry in women with PCOS to a healthy female population...
December 26, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/27990384/a-descriptive-study-of-facial-acanthosis-nigricans-and-its-association-with-body-mass-index-waist-circumference-and-insulin-resistance-using-homa2-ir
#4
Shyam Verma, Resham Vasani, Rajiv Joshi, Meghana Phiske, Pritesh Punjabi, Tushar Toprani
INTRODUCTION: The term facial acanthosis nigricans (FAN) lacks definition of precise clinical and histopathological features. We present a descriptive study of patients with FAN to define pigmentary patterns and estimate the prevalence of obesity and insulin resistance in these cases. MATERIALS AND METHODS: It is a prospective study that included all patients with classical AN of the neck and/or other areas with facial acanthosis nigricans described as brown-to-black macular pigmentation with blurred ill-defined margins, found on the zygomatic and malar areas...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27967300/clinical-features-and-management-of-non-hiv-related-lipodystrophy-in-children-a-systematic-review
#5
Nidhi Gupta, Noor Asi, Wigdan Farah, Jehad Almasri, Patricia Moreno Barrionuevo, Mouaz Alsawas, Zhen Wang, Morey W Haymond, Rebecca J Brown, M Hassan Murad
CONTEXT: Lipodystrophy syndromes are characterized by generalized or partial absence of adipose tissue, usually associated with insulin resistance-related conditions. OBJECTIVE: We conducted a systematic review to synthesize existing data on clinical and metabolic features of lipodystrophy (age at onset < 18 years). DATA SOURCE: Sources included Medline, Embase, Cochrane Library, Scopus and Non-Indexed Citations from inception through January 2016...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27930697/early-antenatal-prediction-of-gestational-diabetes-in-obese-women-development-of-prediction-tools-for-targeted-intervention
#6
Sara L White, Debbie A Lawlor, Annette L Briley, Keith M Godfrey, Scott M Nelson, Eugene Oteng-Ntim, Stephen C Robson, Naveed Sattar, Paul T Seed, Matias C Vieira, Paul Welsh, Melissa Whitworth, Lucilla Poston, Dharmintra Pasupathy
All obese women are categorised as being of equally high risk of gestational diabetes (GDM) whereas the majority do not develop the disorder. Lifestyle and pharmacological interventions in unselected obese pregnant women have been unsuccessful in preventing GDM. Our aim was to develop a prediction tool for early identification of obese women at high risk of GDM to facilitate targeted interventions in those most likely to benefit. Clinical and anthropometric data and non-fasting blood samples were obtained at 15+0-18+6 weeks' gestation in 1303 obese pregnant women from UPBEAT, a randomised controlled trial of a behavioural intervention...
2016: PloS One
https://www.readbyqxmd.com/read/27908213/determinants-of-low-bone-mineral-density-in-premenopausal-polycystic-ovary-syndrome-patients
#7
Cihan Karadağ, Tevfik Yoldemir, Dilek Gogas Yavuz
OBJECTIVE: The aim of this study was to evaluate the bone mineral density (BMD) values and to determine the associations between BMD and insulin sensitivity, hyperandrogenemia, body mass index (BMI), and sex hormones in premenopausal polycystic ovary syndrome (PCOS) patients. METHODS: A hundred and three women with PCOS and sixty age- and BMI-matched healthy control women were enrolled to this cross-sectional study. Serum androgen and estradiol (E2) levels were measured...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27862896/homozygous-lipe-mutation-in-siblings-with-multiple-symmetric-lipomatosis-partial-lipodystrophy-and-myopathy
#8
Sagit Zolotov, Chao Xing, Riad Mahamid, Adel Shalata, Mohammed Sheikh-Ahmad, Abhimanyu Garg
Despite considerable progress in identifying causal genes for lipodystrophy syndromes, the molecular basis of some peculiar adipose tissue disorders remains obscure. In an Israeli-Arab pedigree with a novel autosomal recessive, multiple symmetric lipomatosis (MSL), partial lipodystrophy and myopathy, we conducted exome sequencing of two affected siblings to identify the disease-causing mutation. The 41-year-old female proband and her 36-year-old brother reported marked accumulation of subcutaneous fat in the face, neck, axillae, and trunk but loss of subcutaneous fat from the lower extremities and progressive distal symmetric myopathy during adulthood...
January 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27766968/body-condition-score-morphometric-measurements-and-estimation-of-body-weight-in-mature-icelandic-horses-in-denmark
#9
Rasmus B Jensen, Signe H Danielsen, Anne-Helene Tauson
BACKGROUND: Obesity is related to the development of several diseases like insulin resistance and laminitis in horses. The prevalence of obesity among mature Icelandic horses in Denmark has not been investigated previously. This study aimed to find the prevalence of obesity, to compare body condition score (BCS) based on owner perception with that of an experienced person and to correlate the BCS to body weight (BW) and morphometric measures in a group of mature Icelandic horses in Denmark...
October 20, 2016: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27755516/-woman-19-old-with-hirsutism-obesity-and-acanthosis-nigricans
#10
Anna Kępczyńska-Nyk, Marta Muszel, Mikołaj Radziszewski, Kamil Wocial
19-year-old hirsute woman with obesity, skin lesions with features of acanthosis nigricans around neck, armpits, thoracic cage and wrists escalating for couple of months, elevated testosterone and insulin plasma levels was admitted to hospital to perform diagnostic approach. The final diagnosis was hyperandrogenism-insulin resistance-acanthosis nigricans syndrome (HAIR-AN syndrome), considered as a subtype of policystic ovary syndrome (PCOS) and impaired glucose tolerance. HAIR-AN is characterized by coexistence of: hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN)...
September 29, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27716204/insulin-growth-factor-1-like-receptor-igf-1r
#11
Gopal Iyer, James Price, Shay Bourgeois, Eric Armstrong, Shyhmin Huang, Paul M Harari
BACKGROUND: The epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and several other human cancers. Monoclonal antibodies, such as cetuximab that block EGFR signaling, have emerged as valuable molecular targeting agents in clinical cancer therapy. Prolonged exposure to cetuximab can result in cells acquiring resistance by a process that remains incompletely understood. METHODS: In this study, we analyzed the immediate early molecular response of cetuximab on physical interactions between EGFR and Insulin growth factor 1 like receptor (IGF-1R) in head and neck cancer cells that are resistant to cetuximab...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27477619/insulin-sensitivity-body-composition-and-adipose-depots-following-12-w-combined-endurance-and-strength-training-in-dysglycemic-and-normoglycemic-sedentary-men
#12
COMPARATIVE STUDY
Torgrim Mikal Langleite, Jørgen Jensen, Frode Norheim, Hanne Løvdal Gulseth, Daniel Steensen Tangen, Kristoffer Jensen Kolnes, Ansgar Heck, Tryggve Storås, Guro Grøthe, Marius Adler Dahl, Anders Kielland, Torgeir Holen, Hans Jørgen Noreng, Hans Kristian Stadheim, Atle Bjørnerud, Egil Ivar Johansen, Birgitte Nellemann, Kåre Inge Birkeland, Christian A Drevon
CONTEXT: Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise. OBJECTIVE: Investigate the effect of exercise on insulin sensitivity, body composition and adipose depots in sedentary men with (n = 11) or without (n = 11) overweight and dysglycemia. MATERIAL AND METHODS: Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle and adipose tissue biopsies before and after 12 weeks combined strength and endurance exercise...
October 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27457430/relation-of-body-circumferences-to-cardiometabolic-disease-in-overweight-obese-subjects
#13
Ernesto Maddaloni, Ilaria Cavallari, Mariangela De Pascalis, Hillary Keenan, Kyoungmin Park, Silvia Manfrini, Raffaella Buzzetti, Giuseppe Patti, Germano Di Sciascio, Paolo Pozzilli
Body circumferences have been proposed as potential anthropometric measures for the assessment of cardiometabolic risk as they are independently associated with insulin resistance and diabetes. The aim of this study was to validate neck and wrist circumference and waist-to-hip ratio as practical markers of metabolic dysfunction and atherosclerosis; 120 subjects who underwent coronary angiography and carotid Doppler ultrasound were enrolled in this cross-sectional study. Exclusion criteria were history of diabetes, acute myocardial infarction, body mass index (BMI) <18...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27324702/genetic-predisposition-to-obesity-is-associated-with-insulin-secretion-in-chinese-adults-the-cardiometabolic-risk-in-chinese-crc-study
#14
Jun Liang, Yuting Sun, Xuekui Liu, Yan Zhu, Ying Pei, Yu Wang, Qinqin Qiu, Manqing Yang, Lu Qi
AIMS: The etiological role of obesity in determining diabetes risk among Asians may be different from that among Caucasians. The current study aimed to investigate the association between genetic predisposition to obesity and measures of insulin secretion and resistance in a large Chinese cohort. METHODS: Study samples were from a community-based health examination survey in central China. A total of 2058 subjects with available biomarkers levels were included in the present study...
September 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27321876/effect-of-teriparatide-treatment-on-endothelial-function-glucose-metabolism-and-inflammation-markers-in-patients-with-postmenopausal-osteoporosis
#15
Ozgen Celer, Aysen Akalın, Cigdem Oztunali
OBJECTIVE: Teriparatide, an anabolic agent used in the treatment of postmenopausal osteoporosis, can induce effects similar to primary hyperparathyroidism. Our objective was to evaluate the effects of teriparatide on endothelial functions, glucose metabolism and inflammation markers in patients diagnosed with postmenopausal osteoporosis. DESIGN, PATIENTS AND MEASUREMENTS: This was a single-centre, single-arm, 6-month prospective study. Twenty-three postmenopausal women over 65 years old with a lumbar spine or femoral neck T-score of -4·0 or lower and having at least two compression fractures in thoracic or lumbar spine were studied...
October 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27284539/acanthosis-nigricans-associated-with-clear-cell-renal-cell-carcinoma
#16
Fernando Peixoto Ferraz de Campos, Margarita Rosa Aveiga Narvaez, Paola Vasconcellos Soares Reis, Augusto Cesar Marins Gomes, Daniela Kallíope de Sá Paraskevopoulos, Frederico Santana, Oscar Eduardo Hidetoshi Fugita
Acanthosis nigricans (AN), an entity recognized since the 19th century, is a dermatopathy associated with insulin-resistant conditions, endocrinopathies, drugs, chromosome abnormalities and neoplasia. The latter, also known as malignant AN, is mostly related to abdominal neoplasms. Malignant AN occurs frequently among elderly patients. In these cases, the onset is subtle, and spreading involves the flexural regions of the body, particularly the axillae, palms, soles, and mucosa. Gastric adenocarcinoma is the most frequent associated neoplasia, but many others have been reported...
January 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/27250602/-the-role-of-epicardial-fat-and-obesity-parameters-in-the-prediction-of-coronary-heart-disease
#17
Dana Prídavková, Daniela Kantárová, Renáta Lišková, Peter Červeň, František Kovář, Marián Mokáň
BACKGROUND: To assess the relationship of parameters of obesity in relationship to coronary angiography findings with correlation of epicardial fat (EF) thickness in uppermentioned context. METHODS: There were 80 patients examined (43 males, 37 postmenopausal females) undergoing elective coronary angiography. We examined the regular obesity parameters - BMI, waist circumference (WC), neck circumference (NC), total body fat (TBF), and visceral fat (VF) using bioimpedance...
April 2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27088603/endocrine-morphometric-and-ultrasonographic-characterization-of-neck-adiposity-in-andalusian-horses
#18
T Martin-Gimenez, I de Blas, E Aguilera-Tejero, E Diez de Castro, C N Aguirre-Pascasio
Equine metabolic syndrome (EMS) can be diagnosed by hormonal measurements; however, it would be important to find simpler measurements that allow easy identification of affected or at risk individuals. In horses, the dorsal neck region is one of the most frequent anatomical sites for fat deposition and neck obesity has been linked to EMS. The aim of this study was to evaluate the association of hormonal markers of obesity (leptin) and insulin resistance (insulin) with morphometric and ultrasonographic neck measurements in Andalusian horses...
July 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27086488/growth-factor-expression-mediates-resistance-to-egfr-inhibitors-in-head-and-neck-squamous-cell-carcinomas
#19
Susanne R Tepper, Zhixiang Zuo, Arun Khattri, Jochen Heß, Tanguy Y Seiwert
OBJECTIVES: Epidermal growth factor receptor (EGFR)-targeted therapy is frequently used in the treatment of advanced head and neck squamous cell carcinoma (HNSCC). However, constitutive or acquired resistance is common and underlying resistance mechanisms remain poorly understood. We investigated the expression levels of growth factors (GF) in tumor-associated stroma and tumor from HNSCC patients and determined the influence of GFs on EGFR inhibitor efficacy in vitro. MATERIALS AND METHODS: The Chicago HNC Genomic Cohort (CHGC) was queried for GF and receptor tyrosine kinase (RTK) expression...
May 2016: Oral Oncology
https://www.readbyqxmd.com/read/27050332/a-comparison-of-the-clinical-usefulness-of-neck-circumference-and-waist-circumference-in-individuals-with-severe-obesity
#20
Yavor Assyov, Antoaneta Gateva, Adelina Tsakova, Zdravko Kamenov
: Purpose/Aim: Neck circumference (NC) is an emerging anthropometric parameter that has been proposed to reflect metabolic health. The aim of the current study was to compare its clinical usefulness to waist circumference (WC) in the assessment of individuals with severe obesity. MATERIALS AND METHODS: A total of 255 subjects participated in the study. All anthropometric measurements were done by a single medical professional. Biochemical measurements included oral glucose-tolerance tests (OGTTs), fasting insulin, lipids, and hepatic enzymes...
April 6, 2016: Endocrine Research
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