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https://www.readbyqxmd.com/read/28655190/right-ventricular-function-during-exercise-in-children-after-heart-transplantation
#1
B Cifra, C T Morgan, A Dragulescu, V C Guerra, C Slorach, M K Friedberg, C Manlhiot, B W McCrindle, A I Dipchand, L Mertens
Aims: Right ventricular (RV) dysfunction is a common problem after heart transplant (HTx). In this study, we used semi-supine bicycle ergometry (SSBE) stress echocardiography to evaluate RV systolic and diastolic reserve in paediatric HTx recipients. Methods and results: Thirty-nine pediatric HTx recipients and 23 controls underwent stepwise SSBE stress echocardiography. Colour tissue doppler imaging (TDI) peak systolic (s') and peak diastolic (e') velocities, myocardial acceleration during isovolumic contraction (IVA), and RV free wall longitudinal strain were measured at incremental heart rates (HR)...
June 23, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28655164/role-of-diastolic-function-indices-in-the-risk-stratification-of-patients-with-mixed-aortic-valve-disease
#2
Alexander C Egbe, Arooj R Khan, Amber Boler, Sameh M Said, Jeffrey B Geske, William R Miranda, Emmanuel Akintoye, Heidi M Connolly, Carole A Warnes, Jae K Oh
Aims: Determine the role of diastolic function indices in pre-operative and post-operative risk stratification in patients with moderate mixed aortic valve disease (MAVD). Methods and results: A retrospective study was conducted of asymptomatic patients with moderate MAVD (a combination of moderate aortic stenosis and moderate aortic regurgitation) and an ejection fraction of 50% or more who were followed up at Mayo Clinic from 1 January 2004, to 31 December 2013...
June 23, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28655149/neuromodulation-of-axon-terminals
#3
Darpan Chakraborty, Dennis Q Truong, Marom Bikson, Hanoch Kaphzan
Understanding which cellular compartments are influenced during neuromodulation underpins any rational effort to explain and optimize outcomes. Axon terminals have long been speculated to be sensitive to polarization, but experimentally informed models for CNS stimulation are lacking. We conducted simultaneous intracellular recording from the neuron soma and axon terminal (blebs) during extracellular stimulation with weak sustained (DC) uniform electric fields in mouse cortical slices. Use of weak direct current stimulation (DCS) allowed isolation and quantification of changes in axon terminal biophysics, relevant to both suprathreshold (e...
June 24, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28654844/exploring-the-mechanisms-of-vehicle-front-end-shape-on-pedestrian-head-injuries-caused-by-ground-impact
#4
Sha Yin, Jiani Li, Jun Xu
In pedestrian-vehicle accidents, pedestrians typically suffer from secondary impact with the ground after the primary contact with vehicles. However, information about the fundamental mechanism of pedestrian head injury from ground impact remains minimal, thereby hindering further improvement in pedestrian safety. This study addresses this issue by using multi-body modeling and computation to investigate the influence of vehicle front-end shape on pedestrian safety. Accordingly, a simulation matrix is constructed to vary bonnet leading-edge height, bonnet length, bonnet angle, and windshield angle...
June 24, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28654750/combining-static-and-dynamical-approaches-for-infrared-spectra-calculations-of-gas-phase-molecules-and-clusters
#5
Daria Ruth Galimberti, Alberto Milani, Matteo Tommasini, Chiara Castiglioni, Marie-Pierre Gaigeot
Four models for the calculation of the IR spectrum of gas phase molecules and clus- ters from molecular dynamics simulations are presented with the aim to reduce the computational cost of the usual Fourier transform (FT) of the time correlation function of the dipole moment. These models are based on the VDOS, FT of time correlation function of velocities, and Atomic Polar Tensors (APT). The models differ from each other by the number of APTs inserted into the velocities correlation function. Excellent accuracy is achieved by the model adopting a weighted linear combination of a few se- lected APTs adapted for the rotation of the molecule (model D)...
June 27, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28654638/increased-inspiratory-resistance-affects-the-dynamic-relationship-between-blood-pressure-changes-and-subarachnoid-space-width-oscillations
#6
Magdalena Wszedybyl-Winklewska, Jacek Wolf, Ewa Swierblewska, Katarzyna Kunicka, Kamila Mazur, Marcin Gruszecki, Pawel J Winklewski, Andrzej F Frydrychowski, Leszek Bieniaszewski, Krzysztof Narkiewicz
BACKGROUND AND OBJECTIVE: Respiration is known to affect cerebrospinal fluid (CSF) movement. We hypothesised that increased inspiratory resistance would affect the dynamic relationship between blood pressure (BP) changes and subarachnoid space width (SAS) oscillations. METHODS: Experiments were performed in a group of 20 healthy volunteers undergoing controlled intermittent Mueller Manoeuvres (the key characteristic of the procedure is that a studied person is subjected to a controlled, increased inspiratory resistance which results in marked potentiation of the intrathoracic negative pressure)...
2017: PloS One
https://www.readbyqxmd.com/read/28654503/effectiveness-of-functional-power-training-on-walking-ability-in-young-children-with-cerebral-palsy-study-protocol-of-a-double-baseline-trial
#7
Liesbeth F van Vulpen, Sonja de Groot, Eugene A A Rameckers, Jules G Becher, Annet J Dallmeijer
PURPOSE: To evaluate the effect of functional high-velocity resistance (power) training to improve walking ability of young children with cerebral palsy. METHODS: Twenty-two children with bi- or unilateral spastic cerebral palsy, Gross Motor Function Classification System levels I and II, aged 4 to 10 years will be recruited. A double-baseline design will be used to compare a 14-week functional power training (3 times a week) program with a 14-week usual care period and a 14-week follow-up period...
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654465/high-velocity-paint-gun-injuries
#8
Wendi E Wohltmann, Joshua A Wisell, Celina M C Lafrades, Daniel M Cramer, Bruce D Ragsdale
Cutaneous injuries due to industrial high-pressure paint guns are well-documented in the literature; however, the histologic characteristics are uncommonly described, and facial involvement has not been previously reported. Histopathologic features of paint gun injuries vary depending on the time since injection and type of material. Early lesions display an acute neutrophilic infiltrate, edema, and thrombosis, with varying degrees of skin, fat, and muscle necrosis. More developed lesions (120-192 hours after injury) have prominent histiocytes and fibrosis around necrotic foci, possibly with the pitfall of muscle regenerative giant cells that could be mistaken for sarcoma...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654211/cleaning-lateral-morphological-features-of-the-root-canal-the-role-of-streaming-and-cavitation
#9
J P Robinson, R G Macedo, B Verhaagen, M Versluis, P R Cooper, L W M van der Sluis, A D Walmsley
AIM: To investigate the effects of ultrasonic activation file type, lateral canal location and irrigant on the removal of a biofilm-mimicking hydrogel from a fabricated lateral canal. Additionally, the amount of cavitation and streaming was quantified for these parameters. METHODOLOGY: An intracanal sonochemical dosimetry method was used to quantify the cavitation generated by an IrriSafe 25 mm length, size 25 file inside a root canal model filled with filtered degassed/saturated water or 3 different concentrations of NaOCl...
June 27, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28654199/imidacloprid-is-hydroxylated-by-laodelphax-striatellus-cyp6ay3v2
#10
R Wang, Y Zhu, L Deng, H Zhang, Q Wang, M Yin, P Song, M E A Elzaki, Z Han, M Wu
Laodelphax striatellus (Fallén) is one of the most destructive pests of rice, and has developed high resistance to imidacloprid. Our previous work indicated a strong association between imidacloprid resistance and the overexpression of a cytochrome P450 gene CYP6AY3v2 in a L. striatellus imidacloprid resistant strain (Imid-R). In this study, a transgenic Drosophila melanogaster line that overexpressed the L. striatellus CYP6AY3v2 gene was established and was found to confer increased levels of imidacloprid resistance...
June 27, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28654066/a-mouse-model-of-single-and-repetitive-mild-traumatic-brain-injury
#11
Bevan S Main, Stephanie S Sloley, Sonia Villapol, David N Zapple, Mark P Burns
Mild Traumatic Brain Injury (mTBI) can result in the acute loss of brain function, including a period of confusion, a loss of consciousness (LOC), focal neurological deficits and even amnesia. Athletes participating in contact sports are at high risk of exposure to large number of mTBIs. In terms of the level of injury in a sporting athlete, a mTBI is defined as a mild injury that does not cause gross pathological changes, but does cause short-term neurological deficits that are spontaneously resolved. Despite previous attempts to model mTBI in mice and rats, many have reported gross adverse effects including skull fractures, intracerebral bleeding, axonal injury and neuronal cell death...
June 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654063/a-tissue-displacement-based-contusive-spinal-cord-injury-model-in-mice
#12
Xiangbing Wu, Yi Ping Zhang, Wenrui Qu, Lisa B E Shields, Christopher B Shields, Xiao-Ming Xu
Producing a consistent and reproducible contusive spinal cord injury (SCI) is critical to minimizing behavioral and histological variabilities between experimental animals. Several contusive SCI models have been developed to produce injuries using different mechanisms. The severity of the SCI is based on the height that a given weight is dropped, the injury force, or the spinal cord displacement. In the current study, we introduce a novel mouse contusive SCI device, the Louisville Injury System Apparatus (LISA) impactor, which can create a displacement-based SCI with high injury velocity and accuracy...
June 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28652715/association-of-arteriosclerosis-and-or-atherosclerosis-with-hypertensive-target-organ-damage-in-the-community-dwelling-elderly-chinese-the-northern-shanghai-study
#13
Ximin Fan, Mengyun Zhu, Chen Chi, Shikai Yu, Jing Xiong, Yuyan Lu, Bin Bai, Yawei Xu, Yi Zhang
OBJECTIVE: Vascular abnormality includes two forms, arteriosclerosis (ARS) and atherosclerosis (ATS), which coexist in patients with cardiovascular (CV) diseases. However, whether their combination may lead to a worsening status in those patients remains unclear. We therefore aimed to investigate the association of ARS and/or ATS with hypertensive target organ damage (TOD). METHODS: From June 2014 to August 2015, a total of 1,599 community-dwelling elderly subjects (aged >65 years) from northern Shanghai were recruited...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28652685/numerical-analysis-of-ion-temperature-effects-to-the-plasma-wall-transition-using-a-one-dimensional-two-fluid-model-i-finite-debye-to-ionization-length-ratio
#14
T Gyergyek, J Kovačič
A one-dimensional, two-fluid, steady state model is used for the analysis of ion temperature effects to the plasma-wall transition. In this paper, the model is solved for a finite ratio ε between the Debye and the ionization length, while in Part II [T. Gyergyek and J. Kovačič, Phys Plasmas 24, 063506 (2017)], the solutions for [Formula: see text] are presented. Ion temperature is treated as a given, independent parameter and it is included in the model as a boundary condition. It is shown that when the ion temperature larger than zero is selected, the ion flow velocity and the electric field at the boundary must be consistent with the selected ion temperature...
June 2017: Physics of Plasmas
https://www.readbyqxmd.com/read/28652671/aortic-velocity-propagation-a-novel-echocardiographic-method-in-predicting-atherosclerotic-coronary-artery-disease-burden
#15
Pakala Vasudeva Chetty, Durgaprasad Rajasekhar, Velam Vanajakshamma, Kummaraganti P Ranganayakulu, Dommara Kranthi Chaithanya
BACKGROUND: The major burden of cardiovascular disease mortality around the globe is due to atherosclerosis and its complications. Hence its early detection and management with easily accessible and noninvasive methods are valuable. Aortic velocity propagation (AVP) through color M-mode of the proximal descending aorta determines aortic stiffness, reflecting atherosclerosis. The aim of this study was to find the utility of AVP in predicting coronary artery disease (CAD) burden assessed through SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score and compared with carotid intima-media thickness (CIMT), which is an established surrogate marker of atherosclerosis...
July 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28652546/clinical-application-of-ghrelin-for-diabetic-peripheral-neuropathy
#16
Hiroaki Ueno, Tomomi Shiiya, Kazuhiro Nagamine, Wakaba Tsuchimochi, Hideyuki Sakoda, Kazutaka Shiomi, Kenji Kangawa, Masamitsu Nakazato
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, and its progression significantly worsens the patient's quality of life. Although several drugs are available for DPN, all of these provide only symptomatic relief. We investigated the therapeutic effects of ghrelin for DPN, based on its various physiological functions. Seven patients with type 2 diabetes with typical clinical signs and symptoms of DPN were hospitalized. Synthetic human ghrelin (1.0 μg/kg) was administered intravenously for 14 days...
2017: Endocrine Journal
https://www.readbyqxmd.com/read/28652350/chimpanzee-super-strength-and-human-skeletal-muscle-evolution
#17
Matthew C O'Neill, Brian R Umberger, Nicholas B Holowka, Susan G Larson, Peter J Reiser
Since at least the 1920s, it has been reported that common chimpanzees (Pan troglodytes) differ from humans in being capable of exceptional feats of "super strength," both in the wild and in captive environments. A mix of anecdotal and more controlled studies provides some support for this view; however, a critical review of available data suggests that chimpanzee mass-specific muscular performance is a more modest 1.5 times greater than humans on average. Hypotheses for the muscular basis of this performance differential have included greater isometric force-generating capabilities, faster maximum shortening velocities, and/or a difference in myosin heavy chain (MHC) isoform content in chimpanzee relative to human skeletal muscle...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28652162/holding-strength-of-a-hem-o-lok-lapra-ty-clip-combination-on-sutures-used-during-partial-nephrectomy
#18
Bikal Paka, Robert Bossemeyer, Mouafak Tourojman, Ruchir Gupta, Brian R Lane
OBJECTIVE: To investigate the anti-slip strength of closing systems employing sutures terminated with a Hem-o-Lok®/Lapra-Ty® clip combination to determine which sutures perform best for this application. Partial nephrectomy (PN) is the reference standard for treatment of small renal masses. The main disadvantage of PN is the risk of technical complications, including renorrhaphy site bleeding and urine leak. MATERIALS AND METHODS: A materials testing system produced a constant velocity pull on the free end of an anchored suture...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28652062/measurement-conditions-of-end-diastolic-ratio-of-common-carotid-arteries-alter-diagnostic-ability-for-large-artery-intracranial-occlusive-disease
#19
Koji Tanaka, Shoji Matsumoto, Hiroyuki Murai, Ryo Yamasaki, Jun-Ichi Kira
BACKGROUND: End-diastolic ratio, calculated by the side-to-side ratio of end-diastolic flow velocities of the common carotid arteries, is an indicator for large artery intracranial occlusive disease. However, the diagnostic ability of end-diastolic ratios derived from different measurement conditions is unclear. METHODS: End-diastolic ratios were measured twice by single carotid duplex ultrasonography. End-diastolic ratio1st was calculated from separate end-diastolic flow velocities measured during routine assessment...
June 23, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28651852/differences-in-repolarization-heterogeneity-among-heart-failure-with-preserved-ejection-fraction-phenotypic-subgroups
#20
Suzanne K Oskouie, Stuart B Prenner, Sanjiv J Shah, Andrew J Sauer
Heart failure with preserved ejection fraction (HFpEF) is a highly heterogeneous syndrome associated with multiple medical comorbidities and pathophysiologic pathways or phenotypes. We recently developed a phenomapping method combining deep phenotyping with machine learning analysis to classify HFpEF patients into 3 clinically distinct phenotypic subgroups (phenogroups) with different clinical outcomes. Phenogroup #1 was younger with lower B-type natriuretic peptide levels, phenogroup #2 had the highest prevalence of obesity and diabetes mellitus, and phenogroup #3 was the oldest with the most factors for chronic kidney disease, the most dysfunctional myocardial mechanics, and the highest adverse outcomes...
May 30, 2017: American Journal of Cardiology
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