keyword
MENU ▼
Read by QxMD icon Read
search

autoregulation

keyword
https://www.readbyqxmd.com/read/29777585/potential-vascular-mechanisms-in-an-ex-vivo-functional-pig-bladder-model
#1
Uzoma A Anele, Paul H Ratz, Andrew F Colhoun, Sydney Roberts, Ryan Musselman, Randy A Vince, John E Speich, Adam P Klausner
AIMS: Chronic ischemia is a recognized factor in the pathophysiology of underactive bladder (UAB). Although relative ischemia (ie, low blood flow) is known to occur during filling, little is known regarding the pathophysiology that leads to UAB. Therefore, we developed an ex vivo functional porcine model to investigate the role of transient ischemia and whether autoregulation, a mechanism that maintains tissue oxygenation in certain vital organs, also exists in the bladder. METHODS: Using bladders from slaughtered pigs, we prepared an isolated perfused model where we studied the effects of bladder perfusion flow rate on perfusion pressure and tissue oxygenation during the filling phase...
May 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29773488/identifying-the-myogenic-and-metabolic-components-of-cerebral-autoregulation
#2
S J Payne
Cerebral autoregulation is the term used to describe a number of mechanisms that act together to maintain a near constant cerebral blood flow in response to changes in arterial blood pressure. These mechanisms are complex and known to be affected in a range of cerebrovascular diseases. However, it can be difficult to assign an alteration in cerebral autoregulation to one of the underlying physiological mechanisms without the use of a complex mathematical model. In this paper, we thus set out a new approach that enables these mechanisms to be related to the autoregulation behaviour and hence inferred from experimental measurements...
May 14, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29770889/autoregulation-in-the-neuro-icu
#3
REVIEW
Anson Wang, Santiago Ortega-Gutierrez, Nils H Petersen
PURPOSE OF REVIEW: The purpose of this review is to briefly describe the concept of cerebral autoregulation, to detail several bedside techniques for measuring and assessing autoregulation, and to outline the impact of impaired autoregulation on clinical and functional outcomes in acute brain injury. Furthermore, we will review several autoregulation studies in select forms of acute brain injuries, discuss the potential for its use in patient management in the ICU, and suggest further avenues for research...
May 17, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29760236/anti-sigma-factor-ylad-regulates-transcriptional-activity-of-sigma-factor-ylac-and-sporulation-via-manganese-dependent-redox-sensing-molecular-switch-in-bacillus-subtilis
#4
Min-Kyu Kwak, Han-Bong Ryu, Sung-Hyun Song, Jin-Won Lee, Sa-Ouk Kang
YlaD, a membrane-anchored anti-sigma factor of Bacillus subtilis , contains a HX3 CXXC motif that functions as a redox-sensing domain and belongs to one of the zinc-coordinated anti-sigma factor families. Despite previously showing that the YlaC transcription is controlled by YlaD, experimental evidence of how the YlaC-YlaD interaction is affected by active cysteines and/or metal ions is lacking. Here, we showed that the P yla promoter is autoregulated solely by YlaC. Moreover, reduced YlaD contained zinc and iron, while oxidized YlaD did not...
May 14, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29756691/cerebrovascular-autoregulation-impairments-during-cardiac-surgery-with-cardiopulmonary-bypass-are-related-to-postoperative-cognitive-deterioration-prospective-observational-study
#5
Birute Kumpaitiene, Milda Svagzdiene, Edmundas Sirvinskas, Virginija Adomaitiene, Vytautas Petkus, Rolandas Zakelis, Solventa Krakauskaite, Romanas Chomskis, Arminas Ragauskas, Teodoro F Dagi, Rimantas Benetis
BACKGROUND: Post-operative cognitive dysfunction (POCD) occurs in approximately 33-83% of patients after cardiac surgery with cardiopulmonary bypass (CPB). Recent clinical data suggest that real-time, intraoperative monitoring of patient- specific cerebrovascular autoregulation (CA) may help to prevent POCD by detecting individual critical limits for mean arterial pressure (MAP) outside which CA is impaired. Objectives of the study were to detect the episodes of impaired CA during cardiac surgery with CPB, and to investigate the association between CA impairment and POCD...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29752351/assessing-the-functional-association-of-intronic-mirnas-with-their-host-genes
#6
Avital Steiman-Shimony, Orr Shtrikman, Hanah Margalit
In human, nearly half of the known microRNAs (miRNAs) are encoded within the introns of protein-coding genes. The embedment of these miRNA genes within the sequences of protein-coding genes alludes to a possible functional relationship between intronic miRNAs and their hosting genes. Several studies, using predicted targets, suggested that intronic miRNAs influence their hosts' function either antagonistically or synergistically. New experimental data of miRNA expression patterns and targets enable exploring this putative association by relying on actual data rather than on predictions...
May 11, 2018: RNA
https://www.readbyqxmd.com/read/29748058/unusual-aspect-of-posterior-reversible-encephalopathy-syndrome-in-an-elderly-adult
#7
Benjamin Hebant, Omar Bennani
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) classically occurs in patients presenting with a sudden increase of arterial pressure or eclampsia, but the range of etiologies is very wide. Although the mechanisms underlying PRES remain unclear, research suggests that when the extent of hypertension exceeds the threshold of cerebral blood flow autoregulation, this induces blood-brain barrier disruption that leads to brain edema. Unusual presentations on magnetic resonance imaging (MRI) are possible, including the involvement of frontal or temporal lobes, cerebellar hemispheres, basal ganglia, brainstem, or deep white matter...
May 7, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29746094/an-engineered-device-for-indoleacetic-acid-production-under-quorum-sensing-signals-enables-cupriavidus-pinatubonensis-jmp134-to-stimulate-plant-growth
#8
Ana Zuniga, Francisco De la Fuente, Fernan Federici, Corinne Lionne, Jerome Bonnet, Victor de Lorenzo, Bernardo Gonzalez
The environmental effects of chemical fertilizers and pesticides have encouraged the quest for new strategies to increase crop productivity with minimal impacts on the natural medium. Plant growth promoting rhizobacteria (PGPR) can contribute to this endeavor by improving fitness through better nutrition acquisition and stress tolerance. Using the neutral (non PGPR) rhizobacterium Cupriavidus pinatubonensis JMP134 as the host, we engineered a regulatory forward loop that triggered the synthesis of the phytohormone indole-3-acetic acid (IAA) in a manner dependent on quorum sensing (QS) signals...
May 10, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29745442/mrpc-a-crp-fnr-homolog-functions-as-a-negative-autoregulator-during-the-myxococcus-xanthus-multicellular-developmental-program
#9
Patrick T McLaughlin, Vidhi Bhardwaj, Brooke E Feeley, Penelope I Higgs
MrpC, a member of the CRP/Fnr superfamily of transcriptional regulators, plays a key role in coordination of the multicellular developmental program in Myxococcus xanthus. Previous reports suggest MrpC is subject to complex regulation including activation by an unusual LonD-dependent proteolytic processing event that removes its unique N-terminal peptide, producing the isoform MrpC2. MrpC2 is proposed to positively autoregulate and regulate transcription of hundreds of genes necessary for both the aggregation and sporulation phases of the developmental program...
May 10, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29744226/cerebral-pathophysiology-in-extracorporeal-membrane-oxygenation-pitfalls-in-daily-clinical-management
#10
REVIEW
Syed Omar Kazmi, Sanjeev Sivakumar, Dimitrios Karakitsos, Abdulrahman Alharthy, Christos Lazaridis
Extracorporeal membrane oxygenation (ECMO) is a life-saving technique that is widely being used in centers throughout the world. However, there is a paucity of literature surrounding the mechanisms affecting cerebral physiology while on ECMO. Studies have shown alterations in cerebral blood flow characteristics and subsequently autoregulation. Furthermore, the mechanical aspects of the ECMO circuit itself may affect cerebral circulation. The nature of these physiological/pathophysiological changes can lead to profound neurological complications...
2018: Critical Care Research and Practice
https://www.readbyqxmd.com/read/29739991/systemic-hypertension-is-not-protective-against-chronic-intraocular-pressure-elevation-in-a-rodent-model
#11
Anna K van Koeverden, Zheng He, Christine T O Nguyen, Algis J Vingrys, Bang V Bui
High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure - intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion pressure, ultimately leading to poor retinal and optic nerve head blood supply...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738857/the-effect-of-tumour-neovasculature-on-fmri-bold-activation
#12
Layla Gould, Chelsea Ekstrand, Daryl R Fourney, Marla J S Mickleborough, Tasha Ellchuk, Ron Borowsky
We report a 40-year-old patient with a large, WHO grade III oligodendroglioma in the left parietal lobe. Presurgical planning included fMRI localization of language, motor, and somatosensory processing. The fMRI results for the motor and somatosensory tasks revealed activation in peri-lesional regions near the surgical resection, as well as deactivation in the tumour for the sensory task, suggesting that there is decreased autoregulation in the region due to the glioma. The fMRI results showed left hemisphere dominance for language, as well as activation in peri-lesional regions for all three speech tasks (i...
May 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29735764/autoregulation-of-the-s-mutans-slor-metalloregulator-is-constitutive-and-driven-by-an-independent-promoter
#13
Patrick Monette, Richard Brach, Annie Cowan, Roger Winters, Jazz Weisman, Foster Seybert, Kelsey Goguen, James Chen, Arthur Glasfeld, Grace Spatafora
Streptococcus mutans , one of ∼600 bacterial species in the human oral cavity, is among the most acidogenic constituents of the plaque biofilm. Considered to be the primary causative agent of dental caries, S. mutans harbors a 25kDa SloR metalloregulatory protein which controls metal ion transport across the bacterial cell membrane to maintain essential metal ion homeostasis. The expression of SloR derives, in part, from transcriptional readthrough of the sloABC operon which encodes a Mn2+ /Fe2+ ABC transport system...
May 7, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29733627/engineering-a-functional-small-rna-negative-autoregulation-network-with-model-guided-design
#14
Chelsea Yongxi Hu, Melissa K Takahashi, Yan Zhang, Julius B Lucks
RNA regulators are powerful components of the synthetic biology toolbox. Here, we expand the repertoire of synthetic gene networks built from these regulators by constructing a transcriptional negative autoregulation (NAR) network out of small RNAs (sRNAs). NAR network motifs are core motifs of natural genetic networks, and are known for reducing network response time and steady state signal noise. Here we use cell-free transcription-translation (TX-TL) reactions and a computational model to design and prototype sRNA NAR constructs...
May 7, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29727362/effect-of-body-temperature-on-cerebral-autoregulation-in-acutely-comatose-neurocritically-ill-patients
#15
Krishma Adatia, Romergryko G Geocadin, Ryan Healy, Wendy Ziai, Luciano Ponce-Mejia, Mirinda Anderson-White, Dhaval Shah, Batya R Radzik, Caitlin Palmisano, Charles W Hogue, Charles Brown, Lucia Rivera-Lara
OBJECTIVES: Impaired cerebral autoregulation following neurologic injury is a predictor of poor clinical outcome. We aimed to assess the relationship between body temperature and cerebral autoregulation in comatose patients. DESIGN: Retrospective analysis of prospectively collected data. SETTING: Neurocritical care unit of the Johns Hopkins Hospital. PATIENTS: Eighty-five acutely comatose patients (Glasgow Coma Scale score of ≤ 8) admitted between 2013 and 2017...
May 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29726017/effect-of-cerebral-flow-autoregulation-function-on-cerebral-flow-rate-under-continuous-flow-left-ventricular-assist-device-support
#16
Selim Bozkurt
Neurological complications in continuous flow left ventricular assist device (CF-LVAD) patients are the second-leading risk of death after multi-organ failure. They are associated with altered blood flow in the cardiovascular system because of CF-LVAD support. Moreover, an impaired cerebral autoregulation function may also contribute to complications such as hyperperfusion in the cerebral circulation under mechanical circulatory support. The aim of this study is to evaluate the effect of cerebral autoregulatory function on cerebral blood flow rate under CF-LVAD support...
May 3, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29725183/dihydroergotamine-complicating-reversible-cerebral-vasoconstriction-syndrome-in-status-migrainosus
#17
Naresh Mullaguri, Madihah Hepburn, Christopher Ryan Newey, Premkumar Chandrasekharan Nattanmai
Reversible cerebral vasoconstriction syndrome (RCVS) is a clinicoradiological syndrome that occurs due to dysfunction of cerebrovascular autoregulation. It is characterized by recurrent thunderclap headache from cerebral vasoconstriction which can cause ischemic infarction, spontaneous intraparenchymal and subarachnoid hemorrhage. This syndrome can be triggered by a variety of etiologies including medications, infectious, and inflammatory conditions. The diagnosis is often delayed due to unawareness among the health-care providers and delayed neuroimaging evidence of vasoconstriction with or without ischemic and/or hemorrhagic infarction...
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29723927/cardiovascular-impact-of-intravenous-caffeine-in-preterm-infants
#18
Jacqueline Huvanandana, Cindy Thamrin, Alistair L McEwan, Murray Hinder, Mark B Tracy
AIM: To evaluate the acute effect of intravenous caffeine on heart rate and blood pressure variability in preterm infants. METHODS: We extracted and compared linear and non-linear features of heart rate and blood pressure variability at two timepoints: prior to and in the two hours following a loading dose of 10 mg/kg caffeine base. RESULTS: We studied 31 preterm infants with arterial blood pressure data and 25 with electrocardiogram data, and compared extracted features prior to and following caffeine administration...
May 3, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29722016/triarabinosylation-is-required-for-nodulation-suppressive-cle-peptides-to-systemically-inhibit-nodulation-in-pisum-sativum
#19
April H Hastwell, Leo Corcilius, James Williams, Peter M Gresshoff, Richard J Payne, Brett J Ferguson
Legumes form root nodules to house beneficial nitrogen-fixing rhizobia bacteria. However, nodulation is resource demanding; hence, legumes evolved a systemic signalling mechanism, called Autoregulation of Nodulation (AON), to control nodule numbers. AON begins with the production of CLE peptides in the root, which are predicted to be glycosylated, transported to the shoot, and perceived. We synthesised variants of nodulation-suppressing CLE peptides to test their activity using petiole feeding to introduce CLE peptides into the shoot...
May 2, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29720993/the-soybean-gmnark-affects-aba-and-salt-responses-in-transgenic-arabidopsis-thaliana
#20
Chunhong Cheng, Changman Li, Diandong Wang, Lifeng Zhai, Zhaoming Cai
GmNARK ( Glycine max nodule autoregulation receptor kinase) is the homolog of Arabidopsis thaliana CLAVATA1 ( CLV1 ) and one of the most important regulators in the process of AON (Autoregulation of Nodulation), a process that restricts excessive nodule numbers in soybean. However, except for the function in AON, little is known about this gene. Here, we report that GmNARK plays important roles in process of plant response to abiotic stresses. Bioinformatic analysis and subcellular localization experiment results showed that GmNARK was a putative receptor like kinase and located at membrane...
2018: Frontiers in Plant Science
keyword
keyword
76062
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"