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Immunization frequency

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https://www.readbyqxmd.com/read/29924452/cellular-expression-of-cd-markers-in-immune-thrombocytopenic-purpura-implications-for-prognosis
#1
Masumeh Maleki Behzad, Ali Amin Asnafi, Mohammad Ali Jalalifar, Mostafa Moghtadaei, Kaveh Jaseb, Najmaldin Saki
Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder associated with platelet destruction. Abnormalities in frequency and function of different immune cells can play a crucial role in this disease. The aim of this study was to evaluate the prognostic value of CD markers' expressions by immune cells in ITP. Peripheral blood samples were collected from 25 ITP patients before and after treatment. The expression of CD markers was evaluated by flow cytometry technique. The expression of CD38 and CD56 was significantly lower before treatment than after it (p = 0...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29922294/increased-regulatory-t-cells-in-peripheral-blood-of-acute-myeloid-leukemia-patients-rely-on-tumor-necrosis-factor-tnf-%C3%AE-tnf-receptor-2-pathway
#2
Min Wang, Chen Zhang, Tian Tian, Teng Zhang, Ruiqing Wang, Fengjiao Han, Chaoqin Zhong, Mingqiang Hua, Daoxin Ma
Acute myeloid leukemia (AML) harbors an immune suppression environment, featured by increased regulatory T cells (Tregs). The expression of tumor necrosis factor receptor-2 (TNFR2) on Tregs could be used to identify the maximally suppressive Treg population, and TNF-α furtherly promoted the expansion and function of Tregs via TNFR2 in mice. However, the role of TNF-α has not been determined in AML patients. In view of high levels of TNF-α and Tregs in AML patients, we hypothesized that the increased frequency of Tregs may rely on TNF-α-TNFR2 pathway...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29922291/transcriptomics-of-the-vaccine-immune-response-priming-with-adjuvant-modulates-recall-innate-responses-after-boosting
#3
Francesco Santoro, Elena Pettini, Dmitri Kazmin, Annalisa Ciabattini, Fabio Fiorino, Gregor D Gilfillan, Ida M Evenroed, Peter Andersen, Gianni Pozzi, Donata Medaglini
Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical importance for the rational design of vaccination strategies. In this study, transcriptomics was employed to profile the effect of the vaccine adjuvant used for priming on the immune response following re-exposure to the vaccine antigen alone. Mice were primed with the chimeric vaccine antigen H56 of Mycobacterium tuberculosis administered alone or with the CAF01 adjuvant and boosted with the antigen alone. mRNA sequencing was performed on blood samples collected 1, 2, and 7 days after priming and after boosting...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29920329/associations-of-immunometabolic-risk-factors-with-symptoms-of-depression-and-anxiety-the-role-of-cardiac-vagal-activity
#4
Mandy X Hu, Brenda W J H Penninx, Eco J C de Geus, Femke Lamers, Dora C-H Kuan, Aidan G C Wright, Anna L Marsland, Matthew F Muldoon, Stephen B Manuck, Peter J Gianaros
OBJECTIVES: This study examined 1) the cross-sectional relationships between symptoms of depression/anxiety and immunometabolic risk factors, and 2) whether these relationships might be explained in part by cardiac vagal activity. METHODS: Data were drawn from the Adult Health and Behavior registries (n=1785), comprised of community dwelling adults (52.8% women, aged 30-54). Depressive symptoms were measured with the Center for Epidemiological Studies Depression Scale (CES-D) and the Beck Depression Inventory-II (BDI-II), and anxious symptoms with the Trait Anxiety scale of the State-Trait Anxiety Inventory (STAI-T)...
June 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29917084/activation-of-peripheral-t-follicular-helper-cells-during-acute-dengue-virus-infection
#5
Kirk Haltaufderhyde, Anon Srikiatkhachorn, Sharone Green, Louis Macareo, Sangshin Park, Siripen Kalayanarooj, Alan L Rothman, Anuja Mathew
Follicular helper T cells (TFH) are specialized CD4 T cells required for B-cell help and antibody production. Given the postulated role of immune activation in dengue disease, we measured the expansion and activation of TFH in the circulation (pTFH) collected from Thai children with laboratory-confirmed acute DENV infection. We found significant expansion and activation of pTFH subsets during acute infection with the highest frequencies of activated pTFH (PD1hi pTFH and PD1+CD38+ pTFH) detected during the critical phase of illness...
June 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29916184/antibiotics-protect-against-eae-by-increasing-regulatory-and-anti-inflammatory-cells
#6
Hilary A Seifert, Gil Benedek, Ha Nguyen, Grant Gerstner, Ying Zhang, Gail Kent, Arthur A Vandenbark, Jürgen Bernhagen, Halina Offner
A seven day pretreatment course of an oral antibiotic cocktail (Ampicillin, Metronidazole, Neomycin Sulfate, and Vancomycin) was shown to induce changes in peripheral immune regulation and protect mice from signs of experimental autoimmune encephalomyelitis (EAE). To determine if a shorter course of antibiotic pretreatment could also protect the mice from EAE and induce regulatory immune cells, studies were conducted using the same oral antibiotic cocktail for three days. In addition, the CNS was examined to determine the effects of antibiotic pretreatment on EAE disease course and immune modulation within the affected tissue...
June 18, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29915592/neonatal-immunity-respiratory-virus-infections-and-the-development-of-asthma
#7
REVIEW
Katherine H Restori, Bharat T Srinivasa, Brian J Ward, Elizabeth D Fixman
Infants are exposed to a wide range of potential pathogens in the first months of life. Although maternal antibodies acquired transplacentally protect full-term neonates from many systemic pathogens, infections at mucosal surfaces still occur with great frequency, causing significant morbidity and mortality. At least part of this elevated risk is attributable to the neonatal immune system that tends to favor T regulatory and Th2 type responses when microbes are first encountered. Early-life infection with respiratory viruses is of particular interest because such exposures can disrupt normal lung development and increase the risk of chronic respiratory conditions, such as asthma...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915171/effects-of-immune-suppression-for-transplantation-on-inflammatory-colorectal-cancer-progression
#8
Imerio Angriman, Lucrezia Furian, Melania Scarpa, Matteo Fassan, Susan Morgan, Andrea Porzionato, Andromachi Kotsafti, Luca Saadeh, Cristina Silvestre, Raffaele De Caro, Amedeo Carraro, Umberto Tedeschi, Romeo Bardini, Paolo Rigotti, Massimo Rugge, Carlo Castoro, Ignazio Castagliuolo, Marco Scarpa
BACKGROUND: Ulcerative colitis patients and transplant recipients are at risk for colorectal cancer. Here, we show that immunosuppressive regimens for kidney transplants are associated with the progression of ulcerative colitis-related carcinogenesis. METHODS: We describe the case of a patient diagnosed with colorectal cancer in ulcerative colitis while on immunosuppressive therapy for a kidney transplant. The immunological microenvironment of the cancer and its mutational status were analyzed, and a mouse colon cancer model was created to replicate the unique clinical conditions...
June 19, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29913200/increased-t-cell-immunosenescence-and-accelerated-maturation-phenotypes-in-older-kidney-transplant-recipients
#9
J M Schaenman, M Rossetti, T Sidwell, V Groysberg, G Sunga, Y Korin, E Liang, X Zhou, B Abdallah, E Lum, S Bunnapradist, T Pham, G Danovitch, E F Reed
Older kidney transplant recipients experience increased rates of infection and death, and less rejection, compared with younger patients. However, little is known about immune dysfunction in older compared with younger kidney transplant recipients and whether it is associated with infection. We evaluated T cell phenotypes including maturation, immune senescence, and exhaustion in a novel investigation into differences in older compared with younger patients receiving identical immune suppression regimens. We evaluated PBMC from 60 kidney transplant recipients (23 older and 37 matched younger patients) by multiparameter immune phenotyping...
June 15, 2018: Human Immunology
https://www.readbyqxmd.com/read/29912065/increased-degranulation-of-immune-cells-is-associated-with-higher-cervical-viral-load-in-hiv-infected-women
#10
Vandana Saxena, Manisha Ghate, Shubhangi Bichare, Ishrat Khan, Raj Majumdar, Mansa Angadi, Smita Kulkarni, Ramesh Paranjape, Madhuri Rajeev Thakar
OBJECTIVE: The activation of effector immune cells at the cervicovaginal mucosa (CVM) might influence the cervical HIV load and thus the secondary transmission; however limited information is available about the innate effector cells at CVM during HIV infection. In this study we quantified and assessed the activation of the effector immune cells at the CVM of HIV infected women with different disease outcomes: non-progressive HIV disease (LTNPs) and chronic HIV-infected (CHI) and their relationship with cervical viral shedding...
June 14, 2018: AIDS
https://www.readbyqxmd.com/read/29910802/parameters-of-the-immune-system-and-vitamin-d-levels-in-old-individuals
#11
Amanda Soares Alves, Mayari Eika Ishimura, Yeda Aparecida de Oliveira Duarte, Valquiria Bueno
Aim: The increased number of individuals older than 80 years, centenarians, and supercentenarians is not a synonym for healthy aging, since severe infections, hospitalization, and disability are frequently observed. In this context, a possible strategy is to preserve the main characteristics/functions of the immune system with the aim to cause less damage to the organism during the aging process. Vitamin D acts on bone marrow, brain, breast, malignant cells, and immune system and has been recommended as a supplement...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29907866/intestinal-damage-precedes-mucosal-immune-dysfunction-in-siv-infection
#12
Tiffany Hensley-McBain, Alicia R Berard, Jennifer A Manuzak, Charlene J Miller, Alexander S Zevin, Patricia Polacino, Jillian Gile, Brian Agricola, Mark Cameron, Shiu-Lok Hu, Jacob D Estes, R Keith Reeves, Jeremy Smedley, Brandon F Keele, Adam D Burgener, Nichole R Klatt
HIV and pathogenic SIV infection are characterized by mucosal dysfunction including epithelial barrier damage, loss of Th17 cells, neutrophil infiltration, and microbial translocation with accompanying inflammation. However, it is unclear how and when these contributing factors occur relative to one another. In order to determine whether any of these features initiates the cycle of damage, we longitudinally evaluated the kinetics of mucosal and systemic T-cell activation, microbial translocation, and Th17 cell and neutrophil frequencies following intrarectal SIV infection of rhesus macaques...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29907389/the-possible-role-of-an-autoimmune-mechanism-in-the-etiopathogenesis-of-parkinson-s-disease
#13
Savvas Dalitis, Natalia Filippidou, George Krashias, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides
The clinical diagnosis of Parkinson's disease (PD) is established through clinical signs such as bradykinesia, rigidity, and resting tremor. Recently, immune system involvement has been implicated as a major pathogenic factor in the onset and progression of PD. We examine the presence of autoantibodies against phosphatidylserine (PS), cardiolipin (CL) and dsDNA in 45 PD patients and 38 healthy controls and provide evidence to the possible connection to oxidative stress. We report higher frequency of IgG anti-PS and anti-dsDNA in PD patients (24...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29907093/effect-of-administration-of-a-probiotic-preparation-on-gut-microbiota-and-immune-response-in-healthy-women-in-india-an-open-label-single-arm-pilot-study
#14
Ankita Singh, Aditya N Sarangi, Amit Goel, Rajni Srivastava, Rajat Bhargava, Priyanka Gaur, Amita Aggarwal, Rakesh Aggarwal
BACKGROUND: Probiotics have been shown to be useful for the treatment of many disease conditions. These beneficial effects are believed to be mediated by change in the composition of gut microbiota and modulation of the host immune responses. However, the available data on the effect of probiotics on these parameters are quite limited. METHODS: We studied the composition of fecal microbiota, using 16S rRNA sequencing, and host immune responses in peripheral blood (plasma cytokine levels, T cell subsets and in vitro cytokine production after stimulation with anti-CD3/CD28 antibody or lipopolysaccharide) in a group of 14 healthy women at three time-points - before and after administration of a probiotic preparation (a capsule of VSL#3, each containing 112...
June 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29904569/the-rs2167270-polymorphism-of-leptin-gene-is-associated-with-atopic-dermatitis
#15
Saleem A Banihani, Rawan A Elmadhoun, Omar F Khabour, Karem H Alzoubi
Atopic dermatitis is a chronic inflammatory skin disease that arises because of complex environmental, immunological, and genetic interactions. Adipokines are bioactive mediators secreted from adipocytes of white adipose tissue and are known to have a role in body metabolism and regulation of immune responses. Leptin is a proinflammatory adipokine that functions mainly to regulate food intake and energy expenditure. Few studies have implicated adipokines in the pathogenesis of atopic dermatitis. In this study, we investigated the association of three leptin gene polymorphisms: -2548G>A (rs7799039), -188 C/A (rs791620), and A19G (rs2167270), with the incidence of atopic dermatitis...
2018: Dermato-endocrinology
https://www.readbyqxmd.com/read/29900890/latent-tuberculosis-infection-among-patients-with-coronary-artery-stenosis-a-case-control-study
#16
Ahmad Farooq Alsayed Hasanain, Khalid M El-Maghraby, Ali A H Zayed, Amany M A Nafee, Sherif M Abdel-Aal, Sally M Bakkar
Background: The activation of the cell-mediated immune responses by Mycobacterium tuberculosis can promote atherogenesis. Aims: The aim of this study is to determine the frequency of latent tuberculosis infection (LTBI) among patients with coronary artery stenosis (CAS) and to explore the association between LTBI and development of CAS. We conducted a case-control study which included 183 patients' who underwent percutaneous coronary angiography (121 patients with CAS and 62 patients without as a control group)...
April 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29900673/dynamics-of-virus-specific-t-cell-immunity-in-pediatric-liver-transplant-recipients
#17
R J Arasaratnam, I Tzannou, T Gray, P I Aguayo-Hiraldo, M Kuvalekar, S Naik, A Gaikwad, H Liu, T Miloh, J F Vera, R W Himes, F M Munoz, A M Leen
Immunosuppression following solid organ transplantation (SOT) has a deleterious effect on cellular immunity leading to frequent and prolonged viral infections. To better understand the relationship between post-transplant immunosuppression and circulating virus-specific T cells, we prospectively monitored the frequency and function of T cells directed to a range of latent (CMV, EBV, HHV6, BK) and lytic (AdV) viruses in 16 children undergoing liver transplantation for up to 1 year post-transplant. Following transplant, there was an immediate decline in circulating virus-specific T cells, which recovered post-transplant, coincident with the introduction and subsequent routine tapering of immunosuppression...
June 13, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29900061/deficiency-of-host-cd96-and-pd-1-or-tigit-enhances-tumor-immunity-without-significantly-compromising-immune-homeostasis
#18
Heidi Harjunpää, Stephen J Blake, Elizabeth Ahern, Stacey Allen, Jing Liu, Juming Yan, Viviana Lutzky, Kazuyoshi Takeda, Amy Roman Aguilera, Camille Guillerey, Deepak Mittal, Xian Yang Li, William C Dougall, Mark J Smyth, Michele W L Teng
Multiple non-redundant immunosuppressive pathways co-exist in the tumor microenvironment and their co-targeting can increase clinical responses. Indeed, concurrent blockade of CTLA-4 and PD-1 in patients with advanced melanoma increased clinical responses over monotherapy alone although the frequency and severity of immune related adverse events (irAEs) also increased. Nevertheless, a substantial number of patients still display an innate resistance phenotype and are unresponsive to current approved immunotherapies even when utilized in combination...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29900057/d-2-hydroxyglutarate-interferes-with-hif-1%C3%AE-stability-skewing-t-cell-metabolism-towards-oxidative-phosphorylation-and-impairing-th17-polarization
#19
Martin Böttcher, Kathrin Renner, Raffaela Berger, Kristin Mentz, Simone Thomas, Zugey Elizabeth Cardenas-Conejo, Katja Dettmer, Peter J Oefner, Andreas Mackensen, Marina Kreutz, Dimitrios Mougiakakos
D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations. D-2HG acting as an oncometabolite promotes proliferation, anoikis, and differentiation block of hematopoietic cells in an autocrine fashion. However, prognostic impact of IDH mutations and high D-2HG levels remains controversial and might depend on the overall mutational context. An increasing number of studies focus on the permissive environment created by AML blasts to promote immune evasion...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29900050/metformin-blocks-myeloid-derived-suppressor-cell-accumulation-through-ampk-dach1-cxcl1-axis
#20
Guohui Qin, Jingyao Lian, Lan Huang, Qitai Zhao, Shasha Liu, Zhen Zhang, Xinfeng Chen, Dongli Yue, Lifeng Li, Feng Li, Lidong Wang, Viktor Umansky, Bin Zhang, Shengli Yang, Yi Zhang
Purpose : Tumor development has been closely linked to tumor microenvironment, particularly in terms of myeloid-derived suppressive cells (MDSCs), a heterogeneous population of immature myeloid cells that protect tumors from elimination by immune cells. Approaches aimed at blocking MDSC accumulation could improve cancer clinical outcome. Experimental Design : We investigated that metformin suppressed MDSC migration to inhibit cancer progression. Primary tumor tissues were incubated with metformin, and proinflammatory chemokine production was measured...
2018: Oncoimmunology
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