Shang-Chun Li, Li-Hong Gu, Yan-Fang Wang, Li-Mei Wang, Liang Chen, John P Giesy, Xun Tuo, Wen-Li Xu, Qian-Hui Wu, Yi-Qing Liu, Ming-Huo Wu, Yang-Yang Diao, Hao-Hang Zeng, Qing-Bi Zhang
Microcystins (MCs) are the most common cyanobacterial toxins. Epidemiological investigation showed that exposure to MCs can cause gastro-intestinal symptoms, such as gastroenteritis and gastric cancer. MCs can also accumulate in and cause histopathological damage to stomach. However, the exact mechanisms by which MCs cause gastric injury were unclear. In this study, Wistar rats were administrated 50, 75 or 100 μg microcystin-LR (MC-LR)/kg, body mass (bm) via tail vein, and histopathology, response of anti-oxidant system and the proteome of gastric tissues at 24 h after exposure were studied...
December 14, 2023: Science of the Total Environment