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MDD and predictors

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https://www.readbyqxmd.com/read/27888722/a-pilot-study-on-predictors-of-brainstem-raphe-abnormality-in-patients-with-major-depressive-disorder
#1
Milutin Kostić, Ana Munjiza, Danilo Pesic, Amir Peljto, Ivana Novakovic, Valerija Dobricic, Dusica Lecic Tosevski, Milija Mijajlovic
BACKGROUND: Hypo/anechogenicity of the brainstem raphe (BR) structures has been suggested as a possible transcranial parenchymal sonography (TCS) marker associated with depression. AIM: The aim of this study was to analyze possible association of the abnormal BR echogenicity in patients with major depression when compared to healthy controls, and to evaluate its clinical and genetic correlates. METHODS: TCS was performed in 53 patients diagnosed as major depressive disorder (MDD) without psychotic symptoms and in 54 healthy matched controls...
November 22, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27886569/effects-of-a-right-unilateral-ultrabrief-pulse-electroconvulsive-therapy-course-on-health-related-quality-of-life-in-elderly-depressed-patients
#2
W Vaughn McCall, Sarah H Lisanby, Peter B Rosenquist, Mary Dooley, Mustafa M Husain, Rebecca G Knapp, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shawn M McClintock, Martina Mueller, Joan Prudic, Robert M Greenberg, Richard D Weiner, Samuel H Bailine, Mary Anne Riley, Laryssa McCloud, Charles H Kellner
INTRODUCTION: Patients with Major Depressive Disorder (MDD) referred for electroconvulsive therapy (ECT) have poorer Health Related Quality of Life (HRQOL), compared with other patients with MDD, but ECT is associated with significant and durable improvement in HRQOL. However, no prior research has focused exclusively on elderly patients with MDD receiving ECT. METHODS: HRQOL data from 240 depressed patients over the age of 60 was measured with the Medical Outcomes Study Short Form 36 (SF-36)...
November 11, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27863710/predictors-of-remission-from-generalized-anxiety-disorder-and-major-depressive-disorder
#3
Kristen M Kelly, Briana Mezuk
BACKGROUND: The predictors of onset of major depressive disorder (MDD) and generalized anxiety disorder (GAD) are well-characterized. However the factors that predict remission from these conditions are less clear, and the study of this area is further complicated by differing definitions of remission. METHODS: Data come from the National Comorbidity Survey - Replication, and analysis was limited to respondents with a lifetime history of GAD (n=621) or MDD (n=1299) assessed by the Composite International Diagnostic Interview...
October 26, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27835721/functional-recovery-in-major-depressive-disorder-focus-on-early-optimized-treatment
#4
Jeffrey Habert, Martin A Katzman, Oloruntoba J Oluboka, Roger S McIntyre, Diane McIntosh, Glenda M MacQueen, Atul Khullar, Roumen V Milev, Kevin D Kjernisted, Pratap R Chokka, Sidney H Kennedy
Objective: This article presents the case that a more rapid, individualized approach to treating major depressive disorder (MDD) may increase the likelihood of achieving full symptomatic and functional recovery for individual patients and that studies show it is possible to make earlier decisions about appropriateness of treatment in order to rapidly optimize that treatment. Data Sources: A PubMed search was conducted using terms including major depressive disorder, early improvement, predictor, duration of untreated illness, and function...
September 1, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27822942/do-somatic-symptoms-predict-the-severity-of-depression-a-validation-study-of-the-korean-version-of-the-depression-and-somatic-symptoms-scale
#5
Sang Won Jeon, Seo Young Yoon, Young Hoon Ko, Sook Haeng Joe, Yong Ku Kim, Changsu Han, Ho Kyoung Yoon, Chia Yih Liu
This study aimed at exploring the psychometric characteristics of the Korean Version of the Depression and Somatic Symptoms Scale (DSSS) in a clinical sample, and investigating the impact of somatic symptoms on the severity of depression. Participants were 203 consecutive outpatients with current major depressive disorders (MDD) or lifetime diagnosis of MDD. The DSSS was compared with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the 17-items Hamilton Depression Rating Scale (HAMD). The DSSS showed a two-factor structure that accounted for 56...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27811136/serum-brain-derived-neurotrophic-factors-in-taiwanese-patients-with-drug-na%C3%A3-ve-first-episode-major-depressive-disorder-effects-of-antidepressants
#6
Yu-Jie Chiou, Tiao-Lai Huang
BACKGROUND: Brain-derived neurotrophic factors (BDNF) are known to be related to the psychopathology of major depressive disorder (MDD). However, studies focusing on drug-naïve first-episode patients are still rare. METHODS: Over a six-year period, we examined the serum BDNF levels in patients with ?rst-episode drug-naïve MDD and compared them to sex-matched healthy controls. We also investigated the relationships between serum BDNF levels, suicidal behavior, Hamilton Depression Rating Scale (HDRS) scores before and after a 4-week antidepressant treatment...
November 3, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27792971/predictors-of-new-onset-depressive-disorders-results-from-the-longitudinal-finnish-health-2011-study
#7
Niina Markkula, Niko Marola, Tarja Nieminen, Seppo Koskinen, Samuli I Saarni, Tommi Härkänen, Jaana Suvisaari
BACKGROUND: Identifying risk factors for depression is important for understanding etiological mechanisms and targeting preventive efforts. No prior studies have compared risk factors of dysthymia and major depressive disorder (MDD) in a longitudinal setting. METHODS: Predictors of new-onset MDD and dysthymia were examined in a longitudinal general population study (Health 2000 and 2011 Surveys, BRIF8901). 4057 persons free of depressive disorders at baseline were followed up for 11 years...
October 18, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27786144/predicting-relapse-after-antidepressant-withdrawal-a-systematic-review
#8
I M Berwian, H Walter, E Seifritz, Q J M Huys
A substantial proportion of the burden of depression arises from its recurrent nature. The risk of relapse after antidepressant medication (ADM) discontinuation is high but not uniform. Predictors of individual relapse risk after antidepressant discontinuation could help to guide treatment and mitigate the long-term course of depression. We conducted a systematic literature search in PubMed to identify relapse predictors using the search terms '(depress* OR MDD*) AND (relapse* OR recurren*) AND (predict* OR risk) AND (discontinu* OR withdraw* OR maintenance OR maintain or continu*) AND (antidepress* OR medication OR drug)' for published studies until November 2014...
October 27, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27770740/escitalopram-but-not-placebo-modulates-brain-rhythmic-oscillatory-activity-in-the-first-week-of-treatment-of-major-depressive-disorder
#9
Andrew F Leuchter, Aimee M Hunter, Felipe A Jain, Molly Tartter, Caroline Crump, Ian A Cook
Serotonin modulates brain oscillatory activity, and serotonergic projections to the thalamus and cortex modulate the frequency of prefrontal rhythmic oscillations. Changes in serotonergic tone have been reported to shift oscillations between the combined delta-theta (2.5-8 Hz) and the alpha (8-12 Hz) frequency ranges. Such frequency shifts may constitute a useful biomarker for the effects of selective serotonin reuptake inhibitor (SSRI) medications in Major Depressive Disorder (MDD). We utilized quantitative electroencephalography (qEEG) to measure shifts in prefrontal rhythmic oscillations early in treatment with either the SSRI escitalopram or placebo, and examined the relationship between these changes and remission of depressive symptoms...
October 7, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27760534/broader-conceptualization-of-remission-assessed-by-the-remission-from-depression-questionnaire-and-its-association-with-symptomatic-remission-a-prospective-multicenter-observational-study
#10
Alonso Montoya, Jeremie Lebrec, Karen Mary Keane, Irene Fregenal, Antonio Ciudad, Ángel Moríñigo, Luis Agüera-Ortiz, Irene Romera, Inmaculada Gilaberte, Mark Zimmerman
BACKGROUND: Goals of treating major depressive disorder (MDD) include achieving remission and avoiding relapse. It is possible that patients may have a broader view of remission than what is captured via clinician-rated scales. This patient perspective may, in turn, have an impact on treatment outcomes. METHODS: The association between a broader conceptualization of remission, based on the Remission from Depression Questionnaire (RDQ) score at baseline, and being in symptomatic remission after 6 months was evaluated in subjects (N = 613) with MDD in symptomatic remission at baseline (17-item Hamilton Rating Scale for Depression [HAMD-17] ≤7)...
October 19, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27756525/fronto-limbic-effective-connectivity-as-possible-predictor-of-antidepressant-response-to-ssri-administration
#11
Benedetta Vai, Chiara Bulgarelli, Beata R Godlewska, Philip J Cowen, Francesco Benedetti, Catherine J Harmer
The timely selection of the optimal treatment for depressed patients is critical to improve remission rates. The detection of pre-treatment variables able to predict differential treatment response may provide novel approaches for treatment selection. Selective serotonin reuptake inhibitors (SSRIs) modulate the fronto-limbic functional response and connectivity, an effect preceding the overt clinical antidepressant effects. Here we investigated whether the cortico-limbic connectivity associated with emotional bias measured before SSRI administration predicts the efficacy of antidepressant treatment in MDD patients...
October 15, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27722834/incidence-and-persistence-of-major-depressive-disorder-among-people-living-with-hiv-in-uganda
#12
Eugene Kinyanda, Helen A Weiss, Jonathan Levin, Noeline Nakasujja, Harriet Birabwa, Juliet Nakku, Richard Mpango, Heiner Grosskurth, Soraya Seedat, Ricardo Araya, Vikram Patel
Data on the course of major depressive disorder (MDD) among people living with HIV (PLWH) are needed to inform refinement of screening and interventions for MDD. This paper describes the incidence and persistence rate of MDD in PLWH in Uganda. 1099 ART-naïve PLWH attending HIV clinics in Uganda were followed up for 12 months. MDD was assessed using the DSM IV based Mini-International Neuropsychiatric Interview with a prevalence for MDD at baseline of 14.0 % (95 % CI 11.7-16.3 %) reported. Multivariable logistic regression was used to determine predictors of incident and persistent MDD...
October 8, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27693981/anxious-distress-predicts-subsequent-treatment-outcome-and-side-effects-in-depressed-patients-starting-antidepressant-treatment
#13
Roxanne Gaspersz, Femke Lamers, Justine M Kent, Aartjan T F Beekman, Johannes H Smit, Albert M van Hemert, Robert A Schoevers, Brenda W J H Penninx
Evidence has shown that the DSM-5 anxious distress specifier captures a clinically valid construct that predicts a worse clinical course. Although of importance for treatment planning and monitoring, however, the specifier's ability to predict treatment outcome is unknown. This is the first study to examine the ability of the DSM-5 anxious distress specifier to predict treatment response and side effects in depressed patients who recently initiated antidepressant treatment. Patients were from the Netherlands Study of Depression and Anxiety, an ongoing longitudinal cohort study...
September 21, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27685842/is-the-noradrenergic-symptom-cluster-a-valid-construct-in-adjunctive-treatment-of-major-depressive-disorder
#14
Virginia L Stauffer, Peng Liu, Celine Goldberger, Lauren B Marangell, Craig Nelson, Philip Gorwood, Maurizio Fava
OBJECTIVE: To identify symptoms potentially representative of a noradrenergic symptom cluster as possible predictors of response to the selective norepinephrine reuptake inhibitor (NRI) edivoxetine when used as monotherapy or adjunctive treatment in patients with DSM-IV-TR major depressive disorder (MDD). METHODS: Pooled data from 4 adjunctive treatment trials (selective serotonin reuptake inhibitor [SSRI] + edivoxetine 6-18 mg/d vs SSRI + placebo; N = 2,066) and data from 1 monotherapy trial (edivoxetine 6-18 mg/d versus placebo; N = 495) were used to identify predictors of response related to noradrenergic symptoms using a resampling-based ensemble tree method...
September 27, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27631142/time-course-and-predictors-of-suicidal-ideation-during-citalopram-treatment-in-the-star-d-trial
#15
Catherine G Coughlin, Ewgeni Jakubovski, Michael H Bloch
OBJECTIVE: Selective serotonin reuptake inhibitors are first-line treatment for major depressive disorder (MDD), but their impact on suicidal ideation is equivocal. Our goal is to examine the time course and clinical predictors of citalopram-induced suicidal ideation during phase 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. METHODS: Of the 4,041 subjects with DSM-IV nonpsychotic MDD in the STAR*D trial phase 1 (2001-2006), we included in our analysis 3,577 subjects who reported side-effect data and had received citalopram (20-60 mg/d) for 8-14 weeks...
September 13, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27624847/the-association-between-cognitive-function-and-subsequent-depression-a-systematic-review-and-meta-analysis
#16
M A Scult, A R Paulli, E S Mazure, T E Moffitt, A R Hariri, T J Strauman
Despite a growing interest in understanding the cognitive deficits associated with major depressive disorder (MDD), it is largely unknown whether such deficits exist before disorder onset or how they might influence the severity of subsequent illness. The purpose of the present study was to conduct a systematic review and meta-analysis of longitudinal datasets to determine whether cognitive function acts as a predictor of later MDD diagnosis or change in depression symptoms. Eligible studies included longitudinal designs with baseline measures of cognitive functioning, and later unipolar MDD diagnosis or symptom assessment...
September 14, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27616560/variation-in-common-preschool-sleep-problems-as-an-early-predictor-for-depression-and-anxiety-symptom-severity-across-time
#17
Diana J Whalen, Kirsten E Gilbert, Deanna M Barch, Joan L Luby, Andy C Belden
BACKGROUND: Child and adolescent psychopathology has been linked to increased sleep problems, but there has been less investigation of this relationship in younger samples with early-onset psychopathology. This study examined three specific but commonly observed aspects of sleep behaviors in young children - (i) Sleep onset latency, (ii) Refusal to sleep alone, and (iii) Nighttime awakenings - measured during preschool, and investigated whether these sleep problems predicted anxiety and/or depression across the next 6 years until school age (ages 9-13)...
September 12, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27605454/the-extrinsic-coagulation-pathway-a-biomarker-for-suicidal-behavior-in-major-depressive-disorder
#18
Yongtao Yang, Jin Chen, Chengyu Liu, Liang Fang, Zhao Liu, Jing Guo, Ke Cheng, Chanjuan Zhou, Yuan Zhan, Narayan D Melgiri, Liang Zhang, Jiaju Zhong, Jianjun Chen, Chenglong Rao, Peng Xie
Although an association between major depressive disorder (MDD) and suicide exists, most depressed patients never attempt suicide. An improved understanding of the factors contributing to suicidal risk in MDD can provide direction for suicide predictor development. In MDD suicide attempters (MDD-SA), MDD non-attempters (MDD-NA), and healthy controls (HC) (n = 12 each group), complementary plasma proteomics identified 45 differential proteins mapped to coagulation and inflammation, 25 of which underwent Western blotting...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27585739/attenuation-of-frontostriatal-connectivity-during-reward-processing-predicts-response-to-psychotherapy-in-major-depressive-disorder
#19
Erin Walsh, Hannah Carl, Tory Eisenlohr-Moul, Jared Minkel, Andrew Crowther, Tyler Moore, Devin Gibbs, Chris Petty, Josh Bizzell, Moria J Smoski, Gabriel S Dichter
There are few reliable predictors of response to antidepressant treatments. In the present investigation we examined pretreatment functional brain connectivity during reward processing as a potential predictor of response to Behavioral Activation Therapy for Depression (BATD), a validated psychotherapy that promotes engagement with rewarding stimuli and reduces avoidance behaviors. Thirty-three outpatients with MDD and 20 matched controls completed two runs of the monetary incentive delay task during functional magnetic resonance imaging after which participants with MDD received up to 15 sessions of BATD...
September 2, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27475889/glucocorticoid-receptor-dna-methylation-childhood-maltreatment-and-major-depression
#20
Angela C Bustamante, Allison E Aiello, Sandro Galea, Andrew Ratanatharathorn, Carol Noronha, Derek E Wildman, Monica Uddin
INTRODUCTION: Altered DNA methylation (DNAm) levels of hypothalamic-pituitary-adrenal (HPA) axis genes has been associated with exposure to childhood maltreatment (CM) and depression; however, it is unknown whether CM and depression have joint and potentially interacting effects on the glucocorticoid receptor (NR3C1) DNAm. We investigated the impact of CM and lifetime major depressive disorder (MDD) on NR3C1 DNAm and gene expression (GE) in 147 adult participants from the Detroit Neighborhood Health Study...
December 2016: Journal of Affective Disorders
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