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MDD and predictors

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https://www.readbyqxmd.com/read/29920440/association-of-the-loudness-dependence-of-auditory-evoked-potentials-with-clinical-changes-to-repetitive-transcranial-magnetic-stimulation-in-patients-with-depression
#1
Sangmin Lee, Kuk-In Jang, Jeong-Ho Chae
BACKGROUND: Although the application of repetitive transcranial magnetic stimulation (rTMS) for treatment of depression has been well investigated, there are few biological predictors of clinical outcomes to rTMS treatment. Previous studies have suggested that the loudness dependence of auditory evoked potentials (LDAEP) can be used as a predictor of response to antidepressant treatment. However, little is known about the association between rTMS and LDAEP. The present study aimed to investigate whether baseline LDAEP is associated with clinical changes to rTMS treatment in patients with major depressive disorder (MDD), and to explore the effect of high-frequency rTMS on LDAEP...
May 19, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29900802/dementia-and-cognitive-impairment-among-u-s-veterans-with-a-history-of-mdd-or-ptsd-a-retrospective-cohort-study-based-on-sex-and-race
#2
Jagriti Jackie Bhattarai, Mary E Oehlert, Karen D Multon, Scott W Sumerall
OBJECTIVE: The aim of this study was to examine major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) diagnosed at age < 55 as predictors, and sex and race as potential moderators, of dementia and other forms of cognitive impairment. METHOD: Veterans ( N = 4,800) aged ⩾ 56 years were grouped by psychiatric history, sex, and race. Hierarchical and stepwise regression were employed to determine significant predictors. RESULTS: MDD and PTSD were associated with almost double the risk for developing dementia or cognitive impairment at age ⩾ 56...
June 1, 2018: Journal of Aging and Health
https://www.readbyqxmd.com/read/29897037/a-6-year-longitudinal-study-of-predictors-for-suicide-attempts-in-major-depressive-disorder
#3
Merijn Eikelenboom, Aartjan T F Beekman, Brenda W J H Penninx, Johannes H Smit
BACKGROUND: Major depressive disorder (MDD), represent a major source of risk for suicidality. However, knowledge about risk factors for future suicide attempts (SAs) within MDD is limited. The present longitudinal study examined a wide range of putative non-clinical risk factors (demographic, social, lifestyle, personality) and clinical risk factors (depressive and suicidal indicators) for future SAs among persons with MDD. Furthermore, we examined the relationship between a number of significant predictors and the incidence of a future SA...
June 13, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29878827/gender-differences-in-depression-among-veterans-with-spinal-cord-injury
#4
Catherine S Wilson, Stephanie L Nassar, Lisa Ottomanelli, Scott D Barnett, Eni Njoh
PURPOSE: Little is known about gender differences in depression among veterans with spinal cord injury (SCI). Accordingly, the main objectives of this study were (a) to examine demographic and clinical characteristics of veterans with SCI; (b) to investigate gender differences in lifetime depression and depressive symptom severity, including probable major depressive disorder (MDD); and (c) to identify contributory factors (e.g., pain, life satisfaction) for gender differences in depression...
May 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/29806573/prevalence-and-predictors-of-major-depressive-disorder-in-bereaved-caregivers-at-6-and-13-months
#5
Seon-Young Kim, Seung-Jeon Kim, Jae-Min Kim, Sung-Wan Kim, Il-Seon Shin, Hyun-Jeong Shim, Sang-Hee Cho, Ik-Joo Chung, Jin-Sang Yoon
OBJECTIVE: Depressive symptoms are common in bereaved caregivers; however, there have been few prospective studies using a structured interview. This study investigated the prevalence and preloss predictors of major depressive disorder (MDD) in bereaved caregivers of patients in a palliative care unit. METHOD: This prospective cohort study collected caregiver sociodemographic and psychological data before the death of a palliative care unit patient, including MDD, care-burden, coping style, and hopeful attitude...
May 28, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29748628/7t-1-h-mrs-in-major-depressive-disorder-a-ketamine-treatment-study
#6
Jennifer W Evans, Níall Lally, Li An, Ningzhi Li, Allison C Nugent, Dipavo Banerjee, Sam L Snider, Jun Shen, Jonathan P Roiser, Carlos A Zarate
The glutamatergic modulator ketamine has striking and rapid antidepressant effects in major depressive disorder (MDD), but its mechanism of action remains unknown. Proton magnetic resonance spectroscopy (1H-MRS) is the only non-invasive method able to directly measure glutamate levels in vivo; in particular, glutamate and glutamine metabolite concentrations are separable by 1H-MRS at 7T. This double-blind, placebo-controlled, crossover study that included 1 H-MRS scans at baseline and at 24 h post ketamine and post-placebo infusions sought to determine glutamate levels in the pregenual anterior cingulate (pgACC) of 20 medication-free MDD subjects and 17 healthy volunteers (HVs) 24 h post ketamine administration, and to evaluate any other measured metabolite changes, correlates, or predictors of antidepressant response...
April 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29736131/the-association-of-insight-and-change-in-insight-with-clinical-symptoms-in-depressed-inpatients
#7
Hongbo He, Qing Chang, Yarong Ma
Background: Lack of insight has been extensively studied and was found to be adversely correlated with impaired treatment compliance and worse long term clinical outcomes among patients with schizophrenia, while not much is known about this phenonmenon in patients with severe depression. Aim: To explore the correlates of insight and its relation to symptom changes among the most seriously ill patients with affective disorders, those who require hospitalization. Methods: Patients hospitalized in a large psychiatric hospital in south China with either major depressive disorder (MDD)(N=55) or bipolar depression (BD) (N=85) based on ICD-10 diagnostic criteria were assessed with the Insight and Treatment Attitudes Questionnaire (ITAQ) one week after admission and at the time of discharge...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29673146/predictors-of-response-to-ketamine-in-treatment-resistant-major-depressive-disorder-and-bipolar-disorder
#8
Carola Rong, Caroline Park, Joshua D Rosenblat, Mehala Subramaniapillai, Hannah Zuckerman, Dominika Fus, Yena L Lee, Zihang Pan, Elisa Brietzke, Rodrigo B Mansur, Danielle S Cha, Leanna M W Lui, Roger S McIntyre
OBJECTIVES: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depressed sub-populations that are more likely to benefit from ketamine treatment remains a priority. In keeping with this view, the present narrative review aims to identify the pretreatment predictors of response to ketamine in TRD as part of MDD and BD. METHOD: Electronic search engines PubMed/MEDLINE, ClinicalTrials...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29660674/the-relation-of-borderline-personality-disorder-to-aggression-victimization-and-institutional-misconduct-among-prisoners
#9
Kelly E Moore, Robyn L Gobin, Heather L McCauley, Chien-Wen Kao, Stephanie M Anthony, Sheryl Kubiak, Caron Zlotnick, Jennifer E Johnson
OBJECTIVE: Borderline personality disorder (BPD) is highly prevalent among incarcerated populations; however, research has yet to examine whether prisoners diagnosed with BPD experience greater interpersonal dysfunction and institutional misconduct while incarcerated. PROCEDURE: This study drew from a sample of 184 male and female prisoners diagnosed with major depressive disorder (MDD) in a randomized trial of depression treatment. The presence of a BPD diagnosis (n = 69) was analyzed as a predictor of disciplinary incidents/infractions (i...
March 21, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29656263/early-improvement-as-a-predictor-of-final-remission-in-major-depressive-disorder-new-insights-in-electroconvulsive-therapy
#10
Erika Martínez-Amorós, Ximena Goldberg, Verònica Gálvez, Aida de Arriba-Arnau, Virginia Soria, José M Menchón, Diego J Palao, Mikel Urretavizcaya, Narcís Cardoner
BACKGROUND: Early improvement to antidepressant drugs predicts remission, but the predictive value of early improvement to electroconvulsive therapy (ECT) is still unclear. The main aim of this study was to determine the optimal definition of early improvement in the treatment of major depressive disorder (MDD) with ECT, by analyzing its value as a predictor of remission. METHODS: A naturalistic study was conducted in 87 adult MDD patients treated with acute ECT...
August 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29652947/-predictors-of-remission-from-major-depressive-disorder-in-secondary-care
#11
MULTICENTER STUDY
Lilian Salvo, Sandra Saldivia, Carlos Parra, Manuel Cifuentes, Claudio Bustos, Paola Acevedo, Marcela Díaz, Mitza Ormazabal, Ivonne Guerra, Nicol Navarrete, Verónica Bravo, Andrea Castro
Background The knowledge of predictive factors in depression should help to deal with the disease. Aim To assess potential predictors of remission of major depressive disorders (MDD) in secondary care and to propose a predictive model. Material and Methods A 12 month follow-up study was conducted in a sample of 112 outpatients at three psychiatric care centers of Chile, with baseline and quarterly assessments. Demographic, psychosocial, clinical and treatment factors as potential predictors, were assessed. A clinical interview with the checklist of DSM-IV diagnostic criteria, the Hamilton Depression Scale and the List of Threatening Experiences and Multidimensional Scale of Perceived Social Support were applied...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29614105/evaluating-pre-pregnancy-dietary-diversity-vs-dietary-quality-scores-as-predictors-of-gestational-diabetes-and-hypertensive-disorders-of-pregnancy
#12
Selma Gicevic, Audrey J Gaskins, Teresa T Fung, Bernard Rosner, Deirdre K Tobias, Sheila Isanaka, Walter C Willett
BACKGROUND: Dietary diversity scores (DDS) are considered as metrics for monitoring the implementation of the UN's Sustainable Development Goals, but they need to be rigorously evaluated. OBJECTIVE: To examine two DDS, the Food Groups Index (FGI), and the Minimum Dietary Diversity-Women (MDD-W), alongside two dietary quality scores, the Alternate Healthy Eating Index (AHEI-2010) and the Prime Diet Quality Score (PDQS), with risks of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDPs)...
2018: PloS One
https://www.readbyqxmd.com/read/29607163/clinico-radiological-features-and-efficacy-of-anti-fibrotic-agents-in-atypical-idiopathic-pulmonary-fibrosis
#13
Keishi Sugino, Hiroshige Shimizu, Yasuhiko Nakamura, Takuma Isshiki, Keiko Matsumoto, Sakae Homma
Background: Atypical idiopathic pulmonary fibrosis (IPF) including multiple cysts or markedly atelectatic induration in upper lung predominance occasionally can confirm the diagnosis of IPF through a multidisciplinary discussion (MDD) between clinician, radiologist and, pathologist in clinical practice. The aim of this study was to clarify the differences in clinico-radiological characteristics and the efficacy of anti-fibrotic agents between atypical IPF and typical IPF. Methods: We retrospectively evaluated the differences in clinico-radiological characteristics between patients with atypical IPF (n=44) and those with typical IPF (n=87) and examined efficacy of anti-fibrotic agents in atypical IPF...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29595710/cardiovascular-risk-factors-as-differential-predictors-of-incident-atypical-and-typical-major-depressive-disorder-in-u-s-adults
#14
Jay S Patel, Jessica Berntson, Brittanny M Polanka, Jesse C Stewart
OBJECTIVES: While the association between major depressive disorder (MDD) and future cardiovascular disease (CVD) is established, less is known about the relationship between CVD risk factors and future depression, and no studies have examined MDD subtypes. Our objective was to determine whether hypertension, tobacco use, and body mass index (BMI) differentially predict atypical and typical MDD in a national sample of U.S. adults. METHODS: We examined prospective data from 22,915 adults with no depressive disorder history at baseline who participated in Wave 1 (2001-2002) and Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)...
March 28, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29573219/predicting-loneliness-with-polygenic-scores-of-social-psychological-and-psychiatric-traits
#15
A Abdellaoui, M G Nivard, J-J Hottenga, I Fedko, K J H Verweij, B M L Baselmans, E A Ehli, G E Davies, M Bartels, D I Boomsma, J T Cacioppo
Loneliness is a heritable trait that accompanies multiple disorders. The association between loneliness and mental health indices may partly be due to inherited biological factors. We constructed polygenic scores for 27 traits related to behavior, cognition and mental health and tested their prediction for self-reported loneliness in a population-based sample of 8798 Dutch individuals. Polygenic scores for major depressive disorder (MDD), schizophrenia and bipolar disorder were significantly associated with loneliness...
March 23, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29569983/the-development-of-a-novel-high-precision-major-depressive-disorder-screening-system-using-transient-autonomic-responses-induced-by-dual-mental-tasks
#16
Takemi Matsui, Toshikazu Shinba, Guanghao Sun
12.6% of major depressive disorder (MDD) patients have suicide intent, while it has been reported that 43% of patients did not consult their doctors for MDD, automated MDD screening is eagerly anticipated. Recently, in order to achieve automated screening of MDD, biomarkers such as multiplex DNA methylation profiles or physiological method using near infra-red spectroscopy (NIRS) have been studied, however, they require inspection using 96-well DNA ELIZA kit after blood sampling or significant cost. Using a single-lead electrocardiography (ECG), we developed a high-precision MDD screening system using transient autonomic responses induced by dual mental tasks...
February 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29562752/maternal-dietary-diversity-and-growth-of-children-under-24-months-of-age-in-rural-dodoma-tanzania
#17
Megan Huang, Christopher Sudfeld, Abbas Ismail, Said Vuai, Julius Ntwenya, Mary Mwanyika-Sando, Wafaie Fawzi
OBJECTIVE: To identify predictors of maternal dietary diversity in rural Dodoma, Tanzania and assess its association with child growth outcomes. METHODS: A cross-sectional survey of 361 mothers with children under 24 months of age was conducted in 5 villages in rural Dodoma, Tanzania. Maternal diets were assessed using food frequency questionnaires, and dietary diversity was categorized using Minimum Dietary Diversity for Women (MDD-W) guidelines. Child anthropometric measures were taken to calculate height-for-age z-score (HAZ), weight-for-height z-score (WHZ), and weight-for-age z-score (WAZ)...
June 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29561455/major-depression-disorder-trajectories-and-hiv-disease-progression-results-from-a-6-year-outpatient-clinic-cohort
#18
Arthur H Owora
Contradictory evidence exists on the role of Major depression disorder (MDD) as a predictor of human immunodeficiency virus (HIV) disease progression, particularly regarding the effect of MDD presence versus pattern of illness. The objective of this study was to examine whether MDD status and pattern of illness differentially predict HIV disease progression. Retrospective cohort data from a six-year follow-up of HIV patients at an outpatient clinic were analyzed. MDD trajectories were identified by latent class growth analysis and generalized linear mixed models were used to examine their relation to low CD4+ T-lymphocyte counts (<200 cells/μL) during follow-up...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29553848/the-screen-for-cognitive-impairment-in-psychiatry-scip-is-associated-with-disease-severity-and-cognitive-complaints-in-major-depression
#19
Smadar Valérie Tourjman, Robert-Paul Juster, Scot Purdon, Emmanuel Stip, Edouard Kouassi, Stéphane Potvin
OBJECTIVE: To assess the relationship between the Screen for Cognitive Impairment in Psychiatry (SCIP) score and illness severity, subjective cognition and functioning in a cohort of major depressive disorder (MDD) patients. METHODS: Patients (n = 40) diagnosed with MDD (DSM-IV-TR) completed the SCIP, a brief neuropsychological test, and a battery of self-administered questionnaires evaluating functioning (GAF, SDS, WHODAS 2.0, EDEC, PDQ-D5). Disease severity was evaluated with the Hamilton Depression Rating Scale (HDRS) and the Clinical Global Impression (CGI)...
March 19, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29538054/self-efficacy-in-depression-bridging-the-gap-between-competence-and-real-world-functioning
#20
Melissa Milanovic, Emma Ayukawa, Aleksandra Usyatynsky, Katherine Holshausen, Christopher R Bowie
We investigated the discrepancy between competence and real-world performance in major depressive disorder (MDD) for adaptive and interpersonal behaviors, determining whether self-efficacy significantly predicts this discrepancy, after considering depressive symptoms. Forty-two participants (Mage = 37.64, 66.67% female) with MDD were recruited from mental health clinics. Competence, self-efficacy, and real-world functioning were evaluated in adaptive and interpersonal domains; depressive symptoms were assessed with the Beck Depression Inventory II...
May 2018: Journal of Nervous and Mental Disease
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