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MDD and predictors

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https://www.readbyqxmd.com/read/28193126/predictors-of-major-depression-and-posttraumatic-stress-disorder-following-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#1
Maryse C Cnossen, Annemieke C Scholten, Hester F Lingsma, Anneliese Synnot, Juanita Haagsma, Prof Ewout W Steyerberg, Suzanne Polinder
Although major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are prevalent after traumatic brain injury (TBI), little is known about which patients are at risk for developing them. The authors systematically reviewed the literature on predictors and multivariable models for MDD and PTSD after TBI. The authors included 26 observational studies. MDD was associated with female gender, preinjury depression, postinjury unemployment, and lower brain volume, whereas PTSD was related to shorter posttraumatic amnesia, memory of the traumatic event, and early posttraumatic symptoms...
February 14, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28192765/neurophysiological-correlates-of-suicidal-ideation-in-major-depressive-disorder-hyperarousal-during-sleep
#2
Michael R Dolsen, Philip Cheng, J Todd Arnedt, Leslie Swanson, Melynda D Casement, Hyang Sook Kim, Jennifer R Goldschmied, Robert F Hoffmann, Roseanne Armitage, Patricia J Deldin
BACKGROUND: Suicide is a major public health concern, and a barrier to reducing the suicide rate is the lack of objective predictors of risk. The present study considers whether quantitative sleep electroencephalography (EEG) may be a neurobiological correlate of suicidal ideation. METHODS: Participants included 84 (45 female, mean age=26.6) adults diagnosed with major depressive disorder (MDD). The item that measures thoughts of death or suicide on the Quick Inventory of Depressive Symptomatology (QIDS) was used to classify 47 participants as low suicidal ideation (24 females, mean age=26...
January 26, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28180068/early-cortical-biomarkers-of-longitudinal-transcutaneous-vagus-nerve-stimulation-treatment-success-in-depression
#3
Jiliang Fang, Natalia Egorova, Peijing Rong, Jun Liu, Yang Hong, Yangyang Fan, Xiaoling Wang, Honghong Wang, Yutian Yu, Yunyao Ma, Chunhua Xu, Shaoyuan Li, Jingjun Zhao, Man Luo, Bing Zhu, Jian Kong
Transcutaneous vagus nerve stimulation (tVNS), a non-invasive method of brain stimulation through the auricular branch of the vagus nerve, has shown promising results in treating major depressive disorder (MDD) in several pilot studies. However, the neural mechanism by which the effect on depression might be achieved has not been fully investigated, with only a few neuroimaging studies demonstrating tVNS-induced changes in the brains of healthy volunteers. Identifying specific neural pathways, which are influenced by tVNS compared with sham in depressed individuals, as well as determining neurobiomarkers of tVNS treatment success are needed to advance the application of tVNS for MDD...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28168052/dietary-diversity-is-not-associated-with-haematological-status-of-pregnant-women-resident-in-rural-areas-of-northern-ghana
#4
Mahama Saaka, Jeremiah Oladele, Asamoah Larbi, Irmgard Hoeschle-Zeledon
Background. Information regarding how dietary diversity is related to haematological status of the pregnant women in rural areas of Northern Ghana is limited. This study therefore evaluated maternal dietary intake and how it relates to the nutritional status of pregnant women belonging to different socioeconomic conditions in Northern Ghana. Methods. This study was cross-sectional in design involving 400 pregnant women. Midupper arm circumference (MUAC) and anaemia status were used to assess the nutritional status of pregnant women...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28159590/pharmacogenetics-of-antidepressant-response-a-polygenic-approach
#5
Judit García-González, Katherine E Tansey, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Ole Mors, Anna Placentino, Marcella Rietschel, Daniel Souery, Tina Žagar, Piotr M Czerski, Borut Jerman, Henriette N Buttenschøn, Thomas G Schulze, Astrid Zobel, Anne Farmer, Katherine J Aitchison, Ian Craig, Peter McGuffin, Michel Giupponi, Nader Perroud, Guido Bondolfi, David Evans, Michael O'Donovan, Tim J Peters, Jens R Wendland, Glyn Lewis, Shitij Kapur, Roy Perlis, Volker Arolt, Katharina Domschke, Gerome Breen, Charles Curtis, Lee Sang-Hyuk, Carol Kan, Stephen Newhouse, Hamel Patel, Bernhard T Baune, Rudolf Uher, Cathryn M Lewis, Chiara Fabbri
BACKGROUND: Major depressive disorder (MDD) has a high personal and socio-economic burden and >60% of patients fail to achieve remission with the first antidepressant. The biological mechanisms behind antidepressant response are only partially known but genetic factors play a relevant role. A combined predictor across genetic variants may be useful to investigate this complex trait. METHODS: Polygenic risk scores (PRS) were used to estimate multi-allelic contribution to: 1) antidepressant efficacy; 2) its overlap with MDD and schizophrenia...
January 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28097648/a-systematic-review-and-meta-analysis-of-prospective-transition-from-major-depression-to-bipolar-disorder
#6
A Ratheesh, C Davey, S Hetrick, M Alvarez-Jimenez, C Voutier, A Bechdolf, P D McGorry, J Scott, M Berk, S M Cotton
OBJECTIVE: Some people with major depressive disorder (MDD) may be at a pre-onset stage for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We aimed to identify rates and characteristics predictive of transition to BD in prospective follow-up studies of people with MDD. METHODS: Using a systematic search strategy, we identified studies with a diagnostic ascertainment of MDD and BD of an adequate standard, and where the minimum length of follow-up was 6 months...
January 18, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28068613/behavioral-activation-treatment-for-major-depression-a-randomized-trial-of-the-efficacy-of-augmentation-with-cognitive-control-training
#7
Samantha J Moshier, Michael W Otto
BACKGROUND: Major depressive disorder (MDD) is associated with hypoactivation of the dorsolateral prefrontal cortex, a brain region involved in emotion regulation and basic cognitive control processes. Recent studies have indicated that computerized interventions designed to activate this region may reduce depressive and ruminative symptoms. In this double-blind randomized controlled trial, we tested whether one such program, called Cognitive Control Training (CCT), enhanced treatment outcomes when used in adjunct to brief behavior therapy for MDD...
January 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28068461/a-new-prediction-model-for-evaluating-treatment-resistant-depression
#8
Alexander Kautzky, Pia Baldinger-Melich, Georg S Kranz, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: Despite a broad arsenal of antidepressants, about a third of patients suffering from major depressive disorder (MDD) do not respond sufficiently to adequate treatment. Using the data pool of the Group for the Study of Resistant Depression and machine learning, we intended to draw new insights featuring 48 clinical, sociodemographic, and psychosocial predictors for treatment outcome. METHOD: Patients were enrolled starting from January 2000 and diagnosed according to DSM-IV...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28033521/physical-activity-and-sedentary-behavior-in-people-with-major-depressive-disorder-a-systematic-review-and-meta-analysis
#9
REVIEW
Felipe Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Philip Ward, Thaís Reichert, Natália Carvalho Bagatini, Roberta Bgeginski, Brendon Stubbs
BACKGROUND: Low levels of physical activity (PA) and sedentary behavior (SB) are independent risk factors for cardiovascular disease and premature mortality in people with major depressive disorder (MDD). AIMS: Investigate levels of PA and SB and their predictors in people with MDD. METHODS: Electronic databases were searched from inception till 04/2016 for articles measuring PA and SB with a self-report questionnaire (SRQ) or objective measure (e...
November 29, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27997229/incidence-of-mental-health-diagnoses-in-veterans-of-operations-iraqi-freedom-enduring-freedom-and-new-dawn-2001-2014
#10
Christine Ramsey, James Dziura, Amy C Justice, Hamada Hamid Altalib, Harini Bathulapalli, Matthew Burg, Suzanne Decker, Mary Driscoll, Joseph Goulet, Sally Haskell, Joseph Kulas, Karen H Wang, Kristen Mattocks, Cynthia Brandt
OBJECTIVES: To evaluate gender, age, and race/ethnicity as predictors of incident mental health diagnoses among Operations Iraqi Freedom, Enduring Freedom, and New Dawn veterans. METHODS: We used US Veterans Health Administration (VHA) electronic health records from 2001 to 2014 to examine incidence rates and sociodemographic risk factors for mental health diagnoses among 888 142 veterans. RESULTS: Posttraumatic stress disorder (PTSD) was the most frequently diagnosed mental health condition across gender and age groups...
February 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27994930/cortisol-and-hippocampal-volume-as-predictors-of-active-suicidal-behavior-in-major-depressive-disorder-case-report
#11
Theodor Moica, Iosif Gabos Grecu, Sorina Moica, Marieta Gabos Grecu, Gabriela Elena Buicu
BACKGROUND: Suicide is frequently encountered in patients suffering from major depressive disorder (MDD). Since only a third of treated depressed patients are able to achieve remission, in the last few years, new theories have been proposed to better understand the mechanism of this illness. Our paper analyzes the interrelation between cortisol as a marker of neuroendocrine theory as a response to stress, and hippocampal volume subfields in depression as a marker of neurogenesis and neuroplasticity theory...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27966645/divergent-topological-architecture-of-the-default-mode-network-as-a-pretreatment-predictor-of-early-antidepressant-response-in-major-depressive-disorder
#12
Zhenghua Hou, Zan Wang, Wenhao Jiang, Yingying Yin, Yingying Yue, Yuqun Zhang, Xiaopeng Song, Yonggui Yuan
Identifying a robust pretreatment neuroimaging marker would be helpful for the selection of an optimal therapy for major depressive disorder (MDD). We recruited 82 MDD patients [n = 42 treatment-responsive depression (RD) and n = 40 non-responding depression (NRD)] and 50 healthy controls (HC) for this study. Based on the thresholded partial correlation matrices of 58 specific brain regions, a graph theory approach was applied to analyse the topological properties. When compared to HC, both RD and NRD patients exhibited a lower nodal degree (Dnodal) in the left anterior cingulate gyrus; as for RD, the Dnodal of the left superior medial orbitofrontal gyrus was significantly reduced, but the right inferior orbitofrontal gyrus was increased (all P < 0...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27936439/symptoms-of-prolonged-grief-post-traumatic-stress-and-depression-after-loss-in-a-dutch-community-sample-a-latent-class-analysis
#13
A A A Manik J Djelantik, Geert E Smid, Rolf J Kleber, Paul A Boelen
Mental health problems following loss can manifest as heterogeneous symptomatology that may include symptoms of Prolonged Grief Disorder (PGD), Post-Traumatic Stress Disorder (PTSD), and Major Depressive Disorder (MDD). However, the co-occurrence of symptoms of these three disorders is still only partially explored. The aims of this study were to identify subgroups (i.e., classes) in a Dutch sample of bereaved individuals, based on severity and/or co-occurrence of symptoms and to identify predictors for these subgroups, taking into account all three disorders...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27888722/a-pilot-study-on-predictors-of-brainstem-raphe-abnormality-in-patients-with-major-depressive-disorder
#14
Milutin Kostić, Ana Munjiza, Danilo Pesic, Amir Peljto, Ivana Novakovic, Valerija Dobricic, Dusica Lecic Tosevski, Milija Mijajlovic
BACKGROUND: Hypo/anechogenicity of the brainstem raphe (BR) structures has been suggested as a possible transcranial parenchymal sonography (TCS) marker associated with depression. AIM: The aim of this study was to analyze possible association of the abnormal BR echogenicity in patients with major depression when compared to healthy controls, and to evaluate its clinical and genetic correlates. METHODS: TCS was performed in 53 patients diagnosed as major depressive disorder (MDD) without psychotic symptoms and in 54 healthy matched controls...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27886569/effects-of-a-right-unilateral-ultrabrief-pulse-electroconvulsive-therapy-course-on-health-related-quality-of-life-in-elderly-depressed-patients
#15
W Vaughn McCall, Sarah H Lisanby, Peter B Rosenquist, Mary Dooley, Mustafa M Husain, Rebecca G Knapp, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shawn M McClintock, Martina Mueller, Joan Prudic, Robert M Greenberg, Richard D Weiner, Samuel H Bailine, Mary Anne Riley, Laryssa McCloud, Charles H Kellner
INTRODUCTION: Patients with Major Depressive Disorder (MDD) referred for electroconvulsive therapy (ECT) have poorer Health Related Quality of Life (HRQOL), compared with other patients with MDD, but ECT is associated with significant and durable improvement in HRQOL. However, no prior research has focused exclusively on elderly patients with MDD receiving ECT. METHODS: HRQOL data from 240 depressed patients over the age of 60 was measured with the Medical Outcomes Study Short Form 36 (SF-36)...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27863710/predictors-of-remission-from-generalized-anxiety-disorder-and-major-depressive-disorder
#16
Kristen M Kelly, Briana Mezuk
BACKGROUND: The predictors of onset of major depressive disorder (MDD) and generalized anxiety disorder (GAD) are well-characterized. However the factors that predict remission from these conditions are less clear, and the study of this area is further complicated by differing definitions of remission. METHODS: Data come from the National Comorbidity Survey - Replication, and analysis was limited to respondents with a lifetime history of GAD (n=621) or MDD (n=1299) assessed by the Composite International Diagnostic Interview...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27835721/functional-recovery-in-major-depressive-disorder-focus-on-early-optimized-treatment
#17
Jeffrey Habert, Martin A Katzman, Oloruntoba J Oluboka, Roger S McIntyre, Diane McIntosh, Glenda M MacQueen, Atul Khullar, Roumen V Milev, Kevin D Kjernisted, Pratap R Chokka, Sidney H Kennedy
Objective: This article presents the case that a more rapid, individualized approach to treating major depressive disorder (MDD) may increase the likelihood of achieving full symptomatic and functional recovery for individual patients and that studies show it is possible to make earlier decisions about appropriateness of treatment in order to rapidly optimize that treatment. Data Sources: A PubMed search was conducted using terms including major depressive disorder, early improvement, predictor, duration of untreated illness, and function...
September 1, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27822942/do-somatic-symptoms-predict-the-severity-of-depression-a-validation-study-of-the-korean-version-of-the-depression-and-somatic-symptoms-scale
#18
Sang Won Jeon, Seo Young Yoon, Young Hoon Ko, Sook Haeng Joe, Yong Ku Kim, Changsu Han, Ho Kyoung Yoon, Chia Yih Liu
This study aimed at exploring the psychometric characteristics of the Korean Version of the Depression and Somatic Symptoms Scale (DSSS) in a clinical sample, and investigating the impact of somatic symptoms on the severity of depression. Participants were 203 consecutive outpatients with current major depressive disorders (MDD) or lifetime diagnosis of MDD. The DSSS was compared with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the 17-items Hamilton Depression Rating Scale (HAMD). The DSSS showed a two-factor structure that accounted for 56...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27811136/serum-brain-derived-neurotrophic-factors-in-taiwanese-patients-with-drug-na%C3%A3-ve-first-episode-major-depressive-disorder-effects-of-antidepressants
#19
Yu-Jie Chiou, Tiao-Lai Huang
BACKGROUND: Brain-derived neurotrophic factors are known to be related to the psychopathology of major depressive disorder. However, studies focusing on drug-naïve first-episode patients are still rare. METHODS: Over a 6-year period, we examined the serum brain-derived neurotrophic factors levels in patients with first-episode drug-naïve major depressive disorder and compared them with sex-matched healthy controls. We also investigated the relationships between serum brain-derived neurotrophic factors levels, suicidal behavior, and Hamilton Depression Rating Scale scores before and after a 4-week antidepressant treatment...
November 17, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27792971/predictors-of-new-onset-depressive-disorders-results-from-the-longitudinal-finnish-health-2011-study
#20
Niina Markkula, Niko Marola, Tarja Nieminen, Seppo Koskinen, Samuli I Saarni, Tommi Härkänen, Jaana Suvisaari
BACKGROUND: Identifying risk factors for depression is important for understanding etiological mechanisms and targeting preventive efforts. No prior studies have compared risk factors of dysthymia and major depressive disorder (MDD) in a longitudinal setting. METHODS: Predictors of new-onset MDD and dysthymia were examined in a longitudinal general population study (Health 2000 and 2011 Surveys, BRIF8901). 4057 persons free of depressive disorders at baseline were followed up for 11 years...
January 15, 2017: Journal of Affective Disorders
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