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MDD and predictors

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https://www.readbyqxmd.com/read/29673146/predictors-of-response-to-ketamine-in-treatment-resistant-major-depressive-disorder-and-bipolar-disorder
#1
Carola Rong, Caroline Park, Joshua D Rosenblat, Mehala Subramaniapillai, Hannah Zuckerman, Dominika Fus, Yena L Lee, Zihang Pan, Elisa Brietzke, Rodrigo B Mansur, Danielle S Cha, Leanna M W Lui, Roger S McIntyre
OBJECTIVES: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depressed sub-populations that are more likely to benefit from ketamine treatment remains a priority. In keeping with this view, the present narrative review aims to identify the pretreatment predictors of response to ketamine in TRD as part of MDD and BD. METHOD: Electronic search engines PubMed/MEDLINE, ClinicalTrials...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29660674/the-relation-of-borderline-personality-disorder-to-aggression-victimization-and-institutional-misconduct-among-prisoners
#2
Kelly E Moore, Robyn L Gobin, Heather L McCauley, Chien-Wen Kao, Stephanie M Anthony, Sheryl Kubiak, Caron Zlotnick, Jennifer E Johnson
OBJECTIVE: Borderline personality disorder (BPD) is highly prevalent among incarcerated populations; however, research has yet to examine whether prisoners diagnosed with BPD experience greater interpersonal dysfunction and institutional misconduct while incarcerated. PROCEDURE: This study drew from a sample of 184 male and female prisoners diagnosed with major depressive disorder (MDD) in a randomized trial of depression treatment. The presence of a BPD diagnosis (n = 69) was analyzed as a predictor of disciplinary incidents/infractions (i...
March 21, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29656263/early-improvement-as-a-predictor-of-final-remission-in-major-depressive-disorder-new-insights-in-electroconvulsive-therapy
#3
Erika Martínez-Amorós, Ximena Goldberg, Verònica Gálvez, Aida de Arriba-Arnau, Virginia Soria, José M Menchón, Diego J Palao, Mikel Urretavizcaya, Narcís Cardoner
BACKGROUND: Early improvement to antidepressant drugs predicts remission, but the predictive value of early improvement to electroconvulsive therapy (ECT) is still unclear. The main aim of this study was to determine the optimal definition of early improvement in the treatment of major depressive disorder (MDD) with ECT, by analyzing its value as a predictor of remission. METHODS: A naturalistic study was conducted in 87 adult MDD patients treated with acute ECT...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29652947/-predictors-of-remission-from-major-depressive-disorder-in-secondary-care
#4
Lilian Salvo, Sandra Saldivia, Carlos Parra, Manuel Cifuentes, Claudio Bustos, Paola Acevedo, Marcela Díaz, Mitza Ormazabal, Ivonne Guerra, Nicol Navarrete, Verónica Bravo, Andrea Castro
Background The knowledge of predictive factors in depression should help to deal with the disease. Aim To assess potential predictors of remission of major depressive disorders (MDD) in secondary care and to propose a predictive model. Material and Methods A 12 month follow-up study was conducted in a sample of 112 outpatients at three psychiatric care centers of Chile, with baseline and quarterly assessments. Demographic, psychosocial, clinical and treatment factors as potential predictors, were assessed. A clinical interview with the checklist of DSM-IV diagnostic criteria, the Hamilton Depression Scale and the List of Threatening Experiences and Multidimensional Scale of Perceived Social Support were applied...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29614105/evaluating-pre-pregnancy-dietary-diversity-vs-dietary-quality-scores-as-predictors-of-gestational-diabetes-and-hypertensive-disorders-of-pregnancy
#5
Selma Gicevic, Audrey J Gaskins, Teresa T Fung, Bernard Rosner, Deirdre K Tobias, Sheila Isanaka, Walter C Willett
BACKGROUND: Dietary diversity scores (DDS) are considered as metrics for monitoring the implementation of the UN's Sustainable Development Goals, but they need to be rigorously evaluated. OBJECTIVE: To examine two DDS, the Food Groups Index (FGI), and the Minimum Dietary Diversity-Women (MDD-W), alongside two dietary quality scores, the Alternate Healthy Eating Index (AHEI-2010) and the Prime Diet Quality Score (PDQS), with risks of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDPs)...
2018: PloS One
https://www.readbyqxmd.com/read/29607163/clinico-radiological-features-and-efficacy-of-anti-fibrotic-agents-in-atypical-idiopathic-pulmonary-fibrosis
#6
Keishi Sugino, Hiroshige Shimizu, Yasuhiko Nakamura, Takuma Isshiki, Keiko Matsumoto, Sakae Homma
Background: Atypical idiopathic pulmonary fibrosis (IPF) including multiple cysts or markedly atelectatic induration in upper lung predominance occasionally can confirm the diagnosis of IPF through a multidisciplinary discussion (MDD) between clinician, radiologist and, pathologist in clinical practice. The aim of this study was to clarify the differences in clinico-radiological characteristics and the efficacy of anti-fibrotic agents between atypical IPF and typical IPF. Methods: We retrospectively evaluated the differences in clinico-radiological characteristics between patients with atypical IPF (n=44) and those with typical IPF (n=87) and examined efficacy of anti-fibrotic agents in atypical IPF...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29595710/cardiovascular-risk-factors-as-differential-predictors-of-incident-atypical-and-typical-major-depressive-disorder-in-u-s-adults
#7
Jay S Patel, Jessica Berntson, Brittanny M Polanka, Jesse C Stewart
OBJECTIVES: While the association between major depressive disorder (MDD) and future cardiovascular disease (CVD) is established, less is known about the relationship between CVD risk factors and future depression, and no studies have examined MDD subtypes. Our objective was to determine whether hypertension, tobacco use, and body mass index (BMI) differentially predict atypical and typical MDD in a national sample of U.S. adults. METHODS: We examined prospective data from 22,915 adults with no depressive disorder history at baseline who participated in Wave 1 (2001-2002) and Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)...
March 28, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29573219/predicting-loneliness-with-polygenic-scores-of-social-psychological-and-psychiatric-traits
#8
A Abdellaoui, M G Nivard, J-J Hottenga, I Fedko, K J H Verweij, B M L Baselmans, E A Ehli, G E Davies, M Bartels, D I Boomsma, J T Cacioppo
Loneliness is a heritable trait that accompanies multiple disorders. The association between loneliness and mental health indices may partly be due to inherited biological factors. We constructed polygenic scores for 27 traits related to behavior, cognition and mental health and tested their prediction for self-reported loneliness in a population-based sample of 8798 Dutch individuals. Polygenic scores for major depressive disorder (MDD), schizophrenia and bipolar disorder were significantly associated with loneliness...
March 23, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29569983/the-development-of-a-novel-high-precision-major-depressive-disorder-screening-system-using-transient-autonomic-responses-induced-by-dual-mental-tasks
#9
Takemi Matsui, Toshikazu Shinba, Guanghao Sun
12.6% of major depressive disorder (MDD) patients have suicide intent, while it has been reported that 43% of patients did not consult their doctors for MDD, automated MDD screening is eagerly anticipated. Recently, in order to achieve automated screening of MDD, biomarkers such as multiplex DNA methylation profiles or physiological method using near infra-red spectroscopy (NIRS) have been studied, however, they require inspection using 96-well DNA ELIZA kit after blood sampling or significant cost. Using a single-lead electrocardiography (ECG), we developed a high-precision MDD screening system using transient autonomic responses induced by dual mental tasks...
March 23, 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29562752/maternal-dietary-diversity-and-growth-of-children-under-24-months-of-age-in-rural-dodoma-tanzania
#10
Megan Huang, Christopher Sudfeld, Abbas Ismail, Said Vuai, Julius Ntwenya, Mary Mwanyika-Sando, Wafaie Fawzi
OBJECTIVE: To identify predictors of maternal dietary diversity in rural Dodoma, Tanzania and assess its association with child growth outcomes. METHODS: A cross-sectional survey of 361 mothers with children under 24 months of age was conducted in 5 villages in rural Dodoma, Tanzania. Maternal diets were assessed using food frequency questionnaires, and dietary diversity was categorized using Minimum Dietary Diversity for Women (MDD-W) guidelines. Child anthropometric measures were taken to calculate height-for-age z-score (HAZ), weight-for-height z-score (WHZ), and weight-for-age z-score (WAZ)...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29561455/major-depression-disorder-trajectories-and-hiv-disease-progression-results-from-a-6-year-outpatient-clinic-cohort
#11
Arthur H Owora
Contradictory evidence exists on the role of Major depression disorder (MDD) as a predictor of human immunodeficiency virus (HIV) disease progression, particularly regarding the effect of MDD presence versus pattern of illness. The objective of this study was to examine whether MDD status and pattern of illness differentially predict HIV disease progression. Retrospective cohort data from a six-year follow-up of HIV patients at an outpatient clinic were analyzed. MDD trajectories were identified by latent class growth analysis and generalized linear mixed models were used to examine their relation to low CD4+ T-lymphocyte counts (<200 cells/μL) during follow-up...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29553848/the-screen-for-cognitive-impairment-in-psychiatry-scip-is-associated-with-disease-severity-and-cognitive-complaints-in-major-depression
#12
Smadar Valérie Tourjman, Robert-Paul Juster, Scot Purdon, Emmanuel Stip, Edouard Kouassi, Stéphane Potvin
OBJECTIVE: To assess the relationship between the Screen for Cognitive Impairment in Psychiatry (SCIP) score and illness severity, subjective cognition and functioning in a cohort of major depressive disorder (MDD) patients. METHODS: Patients (n = 40) diagnosed with MDD (DSM-IV-TR) completed the SCIP, a brief neuropsychological test, and a battery of self-administered questionnaires evaluating functioning (GAF, SDS, WHODAS 2.0, EDEC, PDQ-D5). Disease severity was evaluated with the Hamilton Depression Rating Scale (HDRS) and the Clinical Global Impression (CGI)...
March 19, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29538054/self-efficacy-in-depression-bridging-the-gap-between-competence-and-real-world-functioning
#13
Melissa Milanovic, Emma Ayukawa, Aleksandra Usyatynsky, Katherine Holshausen, Christopher R Bowie
We investigated the discrepancy between competence and real-world performance in major depressive disorder (MDD) for adaptive and interpersonal behaviors, determining whether self-efficacy significantly predicts this discrepancy, after considering depressive symptoms. Forty-two participants (Mage = 37.64, 66.67% female) with MDD were recruited from mental health clinics. Competence, self-efficacy, and real-world functioning were evaluated in adaptive and interpersonal domains; depressive symptoms were assessed with the Beck Depression Inventory II...
March 13, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29528669/neighborhood-racial-discrimination-and-the-development-of-major-depression
#14
Daniel W Russell, Frederick D Clavél, Carolyn E Cutrona, W Todd Abraham, Rebecca G Burzette
This study examined the impact of neighborhood racial discrimination on the development of major depressive disorder (MDD) in a sample of African American women. Participants were 499 women from Georgia and Iowa with no history of MDD who were followed for 9 to 11 years. Several neighborhood characteristics (community social disorder, community cohesion, and community racism) and individual characteristics (negative life events, financial strain, personal outlook, religious involvement, relationship quality, negative affectivity, and individual experiences of racism) were employed as predictors of whether or not the women met criteria for MDD during this period of time...
February 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29526669/chronic-pain-tbi-and-ptsd-in-military-veterans-a-link-to-suicidal-ideation-and-violent-impulses
#15
Shannon M Blakey, H Ryan Wagner, Jennifer Naylor, Mira Brancu, Ilana Lane, Meghann Sallee, Nathan A Kimbrel, Eric B Elbogen
The polytrauma clinical triad refers to the co-occurrence of chronic pain, traumatic brain injury (TBI), and posttraumatic stress disorder (PTSD). Despite research implicating dyadic relationships between these conditions and adverse outcomes, scant research has examined the polytrauma clinical triad's relation to suicide or violence. The present cross-sectional study was designed to examine whether this complex clinical presentation increases risk of suicidal ideation and violent impulses after accounting for other established risk factors...
March 8, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29507598/undetected-psychiatric-morbidity-among-hiv-aids-patients-attending-comprehensive-care-clinic-ccc-in-nairobi-kenya-towards-an-integrated-mental-health-care
#16
Pauline W Ng'ang'a, Muthoni Mathai, Anne Obondo, Teresia Mutavi, Manasi Kumar
Background: Psychiatric morbidity is commonly associated with HIV disease and may have adverse effects. This aspect may be overlooked at comprehensive HIV care centers in Low and Middle-Income Countries. Objectives: The aim of this study was to determine the prevalence of undetected psychiatric morbidity among HIV/AIDS adult patients attending Comprehensive Care Centre in a semi-urban clinic, in Nairobi, Kenya. Design: Descriptive cross-sectional study of adult HIV patients not receiving any psychiatric treatment was conducted...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29499506/cognitive-complaints-and-predictors-of-perceived-cognitive-dysfunction-in-adults-with-major-depressive-disorder-findings-from-the-cognitive-dysfunction-in-asians-with-depression-cogdad-study
#17
Manit Srisurapanont, Yee Ming Mok, Yen Kuang Yang, Herng-Nieng Chan, Constantine D Della, Nor Zuraida Zainal, Stephen Jambunathan, Nurmiati Amir, Pranab Kalita
BACKGROUND: Several studies have described the presence of perceived cognitive dysfunction amongst Asian patients with major depressive disorder (MDD). To date, no study has been conducted investigating the predictors of perceived cognitive dysfunction amongst Asian MDD patients. METHODS: This was a post-hoc analysis of the Cognitive Dysfunction in Asian patients with Depression (CogDAD) study. Descriptive statistics were used to describe the most common cognitive complaints by patients...
February 16, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29482974/cognitive-predictors-of-illness-course-at-12-months-after-first-episode-of-depression
#18
M Vicent-Gil, A Keymer-Gausset, M Serra-Blasco, M Carceller-Sindreu, J de Diego-Adeliño, J Trujols, M Mur, V Pérez, E Alvarez, N Cardoner, M J Portella
Major Depressive Disorder (MDD) entails cognitive dysfunction in many cognitive domains, but it is still uncertain whether such deficits are present in the early stages. The purpose of the study is to determine the cognitive performance in first episode depression (FED) exploring the presence of different cognitive profiles, and the role of cognition in FED at baseline and long-term. Ninety subjects (18-50 years) were included, 50 patients with a FED and 40 healthy controls. Participants were assessed with a neuropsychological battery, covering language, attention, verbal memory, processing speed and executive domains...
February 23, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29476250/antidepressant-treatment-effects-on-dopamine-transporter-availability-in-patients-with-major-depression-a-prospective-123-i-fp-cit-spect-imaging-genetic-study
#19
Sabine Hellwig, Lars Frings, Annette Masuch, Werner Vach, Katharina Domschke, Claus Normann, Philipp T Meyer
We investigated if sleep deprivation (SD) and electroconvulsive therapy (ECT) affect striatal dopamine transporter (DAT) availability assessed by single-photon emission computed tomography (SPECT) and123 I-FP-CIT, if dopamine transporter gene (SLC6A3; DAT) variation modifies aforementioned parameters, and if SD response or SD-induced DAT changes correlate with ECT response. Sixteen patients with major depression (MDD) referred for ECT and 12 matched controls were prospectively recruited for imaging and SLC6A3 VNTR genotyping...
February 23, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29473140/variance-of-the-global-signal-as-a-pretreatment-predictor-of-antidepressant-treatment-response-in-drug-na%C3%A3-ve-major-depressive-disorder
#20
Jiajia Zhu, Huanhuan Cai, Yonggui Yuan, Yingying Yue, Deguo Jiang, Ce Chen, Wei Zhang, Chuanjun Zhuo, Yongqiang Yu
Several behavioral and neuroimaging markers could be used to predict eventual antidepressant medication (ADM) outcomes in patients with major depressive disorder (MDD). However, these predictors are either subjective or complex, which has limited their clinical use. Thus, we aimed to identify an objective and easy-to-get marker to predict early therapeutic efficacy. Forty-seven drug-naïve patients with MDD and 47 age-, gender- and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) scans...
February 23, 2018: Brain Imaging and Behavior
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