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MDD and predictors

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https://www.readbyqxmd.com/read/29029672/emotion-regulation-protects-against-recurrence-of-depressive-symptoms-following-inpatient-care-for-major-depressive-disorder
#1
David D Ebert, Lisa Hopfinger, Claudi L H Bockting, Matthias Berking
Relapse following response in psychotherapy for major depressive disorder (MDD) is a major concern. Emotion regulation (ER) has been discussed as a putative emerging and maintaining factor for depression. The purpose of the present study was to examine whether ER protects against recurrence of depression over and above residual symptoms of depression following inpatient care for MDD. ER skills (ERSQ-ES) and depression (HEALTH-49) were assessed in 193 patients with MDD (age, M = 47.4, SD = 9.6, 75.1% female, 100% Caucasian) at treatment discontinuation, 3 and 12 months after treatment...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29026309/predicting-treatment-outcomes-of-major-depressive-disorder-by-early-improvement-in-painful-physical-symptoms-a-pooled-analysis-of-double-blind-placebo-controlled-trials-of-duloxetine
#2
Hirofumi Tokuoka, Makoto Nishihara, Shinji Fujikoshi, Aki Yoshikawa, Atsushi Kuga
OBJECTIVE: We determined if early improvement in painful physical symptoms (PPS) can be a predictor of remission in the treatment of major depressive disorder (MDD). METHODS: We included randomized, double-blind, parallel-group clinical trials of duloxetine (40-60 mg/day) versus placebo for the acute treatment of MDD with associated PPS. Only those studies using the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Brief Pain Inventory - Short Form (BPI-SF) were included...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28988102/number-of-illness-episodes-as-predictor-of-residual-symptoms-in-major-depressive-disorder
#3
Gianluca Serafini, Jacopo Nebbia, Nicolò Cipriani, Claudia Conigliaro, Denise Erbuto, Maurizio Pompili, Mario Amore
Notwithstanding major depressive disorder (MDD) is a recurring and chronic condition, relatively few variables have consistently been shown to predict its course. Residual depressive symptoms may be associated with disability and functional impairment but few studies evaluated clinical correlates associated with these symptoms and their impact on functioning after adjustment for potential confounders. Therefore, our study aimed to investigate factors associated with residual depressive symptoms and their impact on the course of MDD...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28971301/distinctive-pretreatment-features-of-bilateral-nucleus-accumbens-networks-predict-early-response-to-antidepressants-in-major-depressive-disorder
#4
Zhenghua Hou, Liang Gong, Mengmeng Zhi, Yingying Yin, Yuqun Zhang, Chunming Xie, Yonggui Yuan
The pretreatment neuroimaging markers from the resting-state brain network that could predict the early response to antidepressants are still unclear. The aim of the present study was to identify the performance of reward network features for discriminating patients with a dampened response to antidepressants. A total of 81 major depressive disorder (MDD) patients (44 patients with treatment-responsive depression (RD) and 37 patients with non-responding depression (NRD)) and 43 healthy controls (HC) underwent resting-state functional magnetic resonance imaging scans and clinical estimates...
October 2, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28958456/associations-between-symptoms-of-depression-and-heart-rate-variability-an-exploratory-study
#5
Lucas Borrione, Andre R Brunoni, Bernardo Sampaio-Junior, Luana M Aparicio, Andrew H Kemp, Isabela Benseñor, Paulo A Lotufo, Renerio Fraguas
Major depressive disorder (MDD) is associated with decreased heart rate variability (HRV), a predictor of cardiovascular morbidity by many, but not all studies. This inconsistency could be due to the association of HRV with specific depressive symptoms. Here, we investigated the association of HRV parameters with components of depressive symptoms from 120 MDD patients, at baseline of a published trial comparing the effect of sertraline to transcranial direct current stimulation. We used Principal Component Analysis to extract components of the Hamilton Rating Scale for Depression (HAM-D-17), the Montgomery Asberg Depression Rating Scale (MADRS) and the Beck Inventory for Depressive Symptomatology (BDI)...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28955271/predictive-roles-of-three-dimensional-psychological-pain-psychache-and-depression-in-suicidal-ideation-among-chinese-college-students
#6
Huanhuan Li, Rong Fu, Yingmin Zou, Yanyan Cui
How to develop an effective screening instrument for predicting suicide risk is an important issue in suicidal research. The aim of the present research was to explore the predictive roles of three screening measures in the evaluation of preexisting suicide risk factors in a sample of undergraduate students. We assessed 1,061 students using the Beck depression and suicidal ideation scales (BDI-I) (BSI), the Psychache Scale (PAS), and the three-dimensional Psychological Pain Scale (TDPPS). Simultaneous multivariate regression analysis showed that the predictive values of pain avoidance scores and BDI scores for suicidal ideation were more significant than that of the PAS scores...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28953649/efficacy-of-escitalopram-monotherapy-in-the-treatment-of-major-depressive-disorder-a-pooled-analysis-of-4-chinese-clinical-trials
#7
Guanjun Li, Yifeng Shen, Jianfeng Luo, Huafang Li
This study aimed to evaluate the efficacy of escitalopram monotherapy in the treatment of major depressive disorder (MDD) on the basis of pooled data analysis of 4 Chinese clinical trials.A total of 649 outpatients with MDD score of ≥18 at the 17-item Hamilton Depression Rating Scale (HAMD17) were included across 4 eligible studies. Patients were treated with 10 mg/day escitalopram for 2 weeks, and then 20 mg/day escitalopram was administered if the clinical response was poor.The change in total HAMD17 score was significantly greater in moderate MDD group than in other subgroups (P < ...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28944312/the-structure-of-personality-disorders-within-a-depressed-sample-implications-for-personalizing-treatment
#8
Joanna M Berg, Jamie C Kennedy, Boadie W Dunlop, Cynthia L Ramirez, Lindsay M Stewart, Charles B Nemeroff, Helen S Mayberg, W Edward Craighead
BACKGROUND: Personality disorders (PDs) and major depressive disorder (MDD) are both significant public health burdens. They are frequently comorbid, and this comorbidity predicts poorer treatment outcomes and lower maintenance of treatment effects. Although there is growing consensus on the structure of personality pathology in non-depressed individuals, there is limited research on the structure of personality pathology in individuals experiencing MDD. METHOD: As part of the Predictors of Remission in Depression to Individual and Combined Treatment (PReDICT) randomized controlled trial, 192 treatment-naïve subjects meeting DSM-IV-TR criteria for MDD completed the International Personality Disorder Examination (IPDE)...
March 2017: Pers Med Psychiatr
https://www.readbyqxmd.com/read/28935838/decreased-pretreatment-amygdalae-serotonin-transporter-binding-in-unipolar-depression-remitters-a-prospective-pet-study
#9
Mala Ananth, Christine DeLorenzo, Jie Yang, J John Mann, Ramin Parsey
Major Depressive Disorder (MDD) is a debilitating condition that affects over 14 million Americans. Remission only occurs in a minority of individuals following first-line antidepressant treatment (~35%); predictors of treatment outcome are therefore needed. Using Positron Emission Tomography (PET) imaging with a radiotracer specific for the serotonin transporter (5-HTT), (11)C-McN5652, we found that patients with MDD who did not achieve remission following 12 months of naturalistic treatment had lower pre-treatment midbrain and amygdala binding compared to healthy volunteers...
September 21, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28934128/neuroticism-predicts-subsequent-risk-of-major-depression-for-whites-but-not-blacks
#10
Shervin Assari
Cultural and ethnic differences in psychosocial and medical correlates of negative affect are well documented. This study aimed to compare blacks and whites for the predictive role of baseline neuroticism (N) on subsequent risk of major depressive episodes (MDD) 25 years later. Data came from the Americans' Changing Lives (ACL) Study, 1986-2011. We used data on 1219 individuals (847 whites and 372 blacks) who had data on baseline N in 1986 and future MDD in 2011. The main predictor of interest was baseline N, measured using three items in 1986...
September 21, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28904815/predictors-help-seeking-behaviour-and-treatment-coverage-for-depression-in-adults-in-sehore-district-india
#11
Rahul Shidhaye, Tanica Lyngdoh, Vaibhav Murhar, Sandesh Samudre, Thomas Krafft
BACKGROUND: National Mental Health Survey found that in India, the point prevalence of major depressive disorder (MDD) was 2.7% and the treatment gap was 85.2%, whereas in Madhya Pradesh the point prevalence of MDD was 1.4% and the treatment gap was 80%. AIMS: To describe the baseline prevalence of depression among adults, association of various demographic and socioeconomic variables with depression and estimation of contact coverage for the same. METHOD: Population-based cross-sectional survey of 3220 adults in Sehore district of Madhya Pradesh, India...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/28895261/the-effects-of-optimism-religion-and-hope-on-mood-and-anxiety-disorders-in-women-with-the-fmr1-premutation
#12
E P Lowell, B L Tonnsen, D B Bailey, J E Roberts
BACKGROUND: The FMR1 premutation, caused by a CGG trinucleotide repeat expansion on the FMR1 gene, has been identified as a genetic risk factor for mood and anxiety disorders. Building on recent studies identifying increased risk for mood and affective disorders in this population, we examined effects of potential protective factors (optimism, religion, hope) on depression and anxiety diagnoses in a prospective, longitudinal cohort. METHODS: Eighty-three women with the FMR1 premutation participated in the Structured Clinical Interview for DSM-IV-TR Disorders at two-time points, 3 years apart...
October 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28886760/network-mechanisms-of-clinical-response-to%C3%A2-transcranial-magnetic-stimulation-in-posttraumatic-stress-disorder-and-major-depressive-disorder
#13
Noah S Philip, Jennifer Barredo, Mascha van 't Wout-Frank, Audrey R Tyrka, Lawrence H Price, Linda L Carpenter
BACKGROUND: Repetitive transcranial magnetic stimulation (TMS) therapy can modulate pathological neural network functional connectivity in major depressive disorder (MDD). Posttraumatic stress disorder is often comorbid with MDD, and symptoms of both disorders can be alleviated with TMS therapy. This is the first study to evaluate TMS-associated changes in connectivity in patients with comorbid posttraumatic stress disorder and MDD. METHODS: Resting-state functional connectivity magnetic resonance imaging was acquired before and after TMS therapy in 33 adult outpatients in a prospective open trial...
August 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28867391/are-there-differences-in-lipid-peroxidation-and-immune-biomarkers-between-major-depression-and-bipolar-disorder-effects-of-melancholia-atypical-depression-severity-of-illness-episode-number-suicidal-ideation-and-prior-suicide-attempts
#14
Magdalena Sowa-Kućma, Krzysztof Styczeń, Marcin Siwek, Paulina Misztak, Rafał J Nowak, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
BACKGROUND: There is evidence that major depression (MDD) and bipolar disorder (BD) are accompanied by activated immune & oxidative (I&O) pathways. METHODS: To compare I&O biomarkers between MDD and BD we assessed serum levels of thiobarbituric acid reactive substances (TBARS; a lipid peroxidation marker), soluble interleukin-2 receptor (sIL-2R), sIL-6R, IL-α, sIL-1R antagonist (sIL-1RA), tumor necrosis factor receptor 60kDa/80kDa (sTNFR60/R80) in 114 MDD and 133 BD patients, and 50 healthy controls...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28866298/disrupted-topology-of-hippocampal-connectivity-is-associated-with-short-term-antidepressant-response-in-major-depressive-disorder
#15
Liang Gong, Zhenghua Hou, Zan Wang, Cancan He, Yingying Yin, Yonggui Yuan, Haisan Zhang, Luxian Lv, Hongxing Zhang, Chunming Xie, Zhijun Zhang
BACKGROUND: Graph theoretical analyses have identified disrupted functional topological organization across the brain in patients with major depressive disorder (MDD). However, the relationship between brain topology and short-term treatment responses in patients with MDD remains unknown. METHODS: Sixty-eight patients with MDD and 63 cognitively normal (CN) subjects were recruited at baseline and underwent resting-state functional magnetic resonance imaging scans...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28842841/high-risk-of-depression-in-high-income-african-american-boys
#16
Shervin Assari, Cleopatra H Caldwell
BACKGROUND: Despite the well-established literature on the protective effect of socioeconomic status (SES) on physical and mental health, there are a few reports on poor mental health of blacks with high SES. Using a national sample, this study investigated the association between household income and risk of major depressive disorder (MDD) in black youth based on ethnicity, gender, and their intersection. METHODS: One thousand one hundred seventeen black adolescents (810 African Americans and 360 Caribbean blacks) were included in the current study...
August 25, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28817491/speed-of-improvement-in-symptoms-of-depression-with-desvenlafaxine-50-mg-and-100-mg-compared-with-placebo-in-patients-with-major-depressive-disorder
#17
Martin A Katzman, Andrew A Nierenberg, Dalia B Wajsbrot, Ellen Meier, Rita Prieto, Elizabeth Pappadopulos, Joan Mackell, Matthieu Boucher
PURPOSE/BACKGROUND: This post hoc analysis examined the time point at which clinically significant improvement in major depressive disorder (MDD) symptoms occurs with desvenlafaxine versus placebo. METHODS: Data were pooled from 9 short-term, double-blind, placebo-controlled studies in adults with MDD randomly assigned to desvenlafaxine 50 mg/d, 100 mg/d, or placebo. A mixed-effects model for repeated-measures analysis of change from baseline score was used to determine the time point at which desvenlafaxine treatment groups separated from placebo on the 17-item Hamilton Rating Scale for Depression and psychosocial outcomes...
October 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28807498/vascular-pathology-and-trajectories-of-late-life-major-depressive-disorder-in-secondary-psychiatric-care
#18
Katherine L Musliner, Peter P Zandi, Xiaoqin Liu, Thomas M Laursen, Trine Munk-Olsen, Preben B Mortensen, William W Eaton
OBJECTIVE: To examine 5-year trajectories of psychiatrist-treated late-life major depressive disorder (MDD), and evaluate whether previous vascular pathology is associated with more severe trajectories of late-life MDD. METHODS: Data were obtained from nationally representative civil, psychiatric, hospital, and prescription registers in Denmark. The sample included 11,092 older adults (≥60 years) who received their first diagnosis of MDD in a psychiatric facility in Denmark between 2000 and 2007...
July 12, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28807138/prevalence-and-predictors-of-post-stroke-mood-disorders-a-meta-analysis-and-meta-regression-of-depression-anxiety-and-adjustment-disorder
#19
Alex J Mitchell, Bhavisha Sheth, John Gill, Motahare Yadegarfar, Brendon Stubbs, Mohammad Yadegarfar, Nick Meader
OBJECTIVE: To ascertain the prevalence and predictors of mood disorders, determined by structured clinical interviews (ICD or DSM criteria) in people after stroke. METHODS: Major electronic databases were searched from inception to June 2016 for studies involving major depression (MDD), minor depression (MnD), dysthymia, adjustment disorder, any depressive disorder (any depressive disorder) and anxiety disorders. Studies were combined using both random and fixed effects meta-analysis and results were stratified as appropriate...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28774163/prevalence-and-co-morbidity-in-common-mental-disorders-and-association-with-suicidal-ideation-in-adult-population
#20
Yousef Veisani, Fathola Mohamadian, Ali Delpisheh
Purpose: Already there are little information on the association between co-morbidities in mental disorders and suicide ideation in developing countries. Current study examines the relationship between co-morbidities in mental disorders and suicide ideation in adult population. Methods: The cross sectional study was conducted using cluster random sampling method in three steps. Data collecting was based on household assets survey and a self-administered 28-item General Health Questionnaire (GHQ-28) as first step to screening and Persian version of the DSM-IVTR was applied to second stage to determine prevalence of mental disorders...
July 22, 2017: Epidemiology and Health
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