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https://www.readbyqxmd.com/read/28107705/incorporation-of-antimicrobial-peptides-in-nanostructured-lipid-membrane-mimetic-bilayer-cubosomes
#1
Thomas G Meikle, Alexandru Zabara, Lynne J Waddington, Frances Separovic, Calum J Drummond, Charlotte E Conn
The inverse bicontinuous lipidic cubic phase offers a simple and robust membrane mimetic with the ability to encapsulate peptides, potentially increasing bioavailability, while also offering a platform from which functionalized, targeted nanoparticles can be developed. Herein we have investigated the use of a number of cubic phase nanoparticle systems with encapsulated antimicrobial peptides gramicidin A', melittin, and alamethicin. The optimal peptide loading ranges, over which cubic symmetry was retained, were determined using small angle X-ray scattering...
January 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28104801/aquatic-insects-in-a-multistress-environment-cross-tolerance-to-salinity-and-desiccation
#2
Susana Pallarés, María Botella-Cruz, Paula Arribas, Andrés Millán, Josefa Velasco
Exposing organims to a particular stressor may enhance tolerance to a subsequent stress, when protective mechanisms against both stressors are shared. Such cross-tolerance is a common adaptive response in dynamic multivariate environments and often indicates potential co-evolution of stress traits. Many aquatic insects in inland saline waters from Mediterranean-climate regions are sequentially challenged with salinity and desiccation stress. Thus, cross-tolerance to these physiologically similar stressors could have been positively selected in insects of these regions...
January 19, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28103664/relaxation-in-a-prototype-ionic-liquid-influence-of-water-on-the-dynamics
#3
David L Price, Oleg Borodin, Miguel A González, Maiko Kofu, Kaoru Shibata, Takeshi Yamada, Osamu Yamamuro, Marie-Louise Saboungi
The influence of water on the relaxation of a prototype ionic liquid (IL) C8mimBF4 is examined in the IL-rich regime combining quasi-elastic neutron scattering (QENS) and molecular dynamics (MD) simulations. The QENS and MD simulations results for relaxation of the IL and the equimolar mixture with water probed by the dynamics of the C8mim hydrogen atoms in the time range of 2 ps - 1 ns are in excellent agreement. The QENS data show that translational relaxation increases by a factor of 7 on addition of water, while rotational relaxation involving multiple processes fitted by a KWW function with low β values is speeded up by a factor of 3 on the timescale of QENS measurements...
January 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28102944/a-simple-and-robust-trajectory-based-stereotactic-radiosurgery-treatment
#4
Byron Wilson, Karl Otto, Ermias Gete
INTRODUCTION: We present a Trajectory-based Volumetric Modulated Arc Therapy (TVMAT) technique for Stereotactic Radiosurgery (SRS) that takes advantage of a modern linacs ability to modulate dose rate and move the couch dynamically. In addition, we investigate the quality of the developed TVMAT method and the dosimetric accuracy of the technique. METHODS: The main feature of the TVMAT technique is a standard beam trajectory formed by dynamic motion of the treatment couch and the linac gantry...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102875/prevalence-of-abnormal-electrocardiograms-in-swiss-elite-athletes-detected-with-modern-screening-criteria
#5
Tilman Perrin, Lukas Daniel Trachsel, Simon Schneiter, Andrea Menafoglio, Silvia Albrecht, Tony Pirrello, Prisca Eser, Laurent Roten, Boris Gojanovic, Matthias Wilhelm
AIMS OF THE STUDY: Sudden cardiac arrest in athletes is a rare but dramatic event. The value of a routine electrocardiogram (ECG) during preparticipation screening (PPS) remains controversial, partly because of the relatively high number of false positive findings. Our study aimed to evaluate the prevalence of abnormal ECGs in consecutive Swiss elite athletes, overall and with regard to different sports classes, using modern screening criteria. METHODS: We analysed the 12-lead resting ECGs of high-level elite athletes (age ≥14 years) recorded at the Swiss Olympic Medical Centre Magglingen between 2013 and 2016 during routine PPS...
January 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28102309/integration-of-visual-and-joint-information-to-enable-linear-reaching-motions
#6
Henry Eberle, Slawomir J Nasuto, Yoshikatsu Hayashi
A new dynamics-driven control law was developed for a robot arm, based on the feedback control law which uses the linear transformation directly from work space to joint space. This was validated using a simulation of a two-joint planar robot arm and an optimisation algorithm was used to find the optimum matrix to generate straight trajectories of the end-effector in the work space. We found that this linear matrix can be decomposed into the rotation matrix representing the orientation of the goal direction and the joint relation matrix (MJRM) representing the joint response to errors in the Cartesian work space...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101732/the-analysis-of-knee-joint-loading-during-drop-landing-from-different-heights-and-under-different-instruction-sets-in-healthy-males
#7
Dmitry Verniba, Jason D Vescovi, David A Hood, William H Gage
BACKGROUND: Mechanical loading during exercise has been shown to promote tissue remodeling. Safe and accessible exercise may be beneficial to populations at risk of diminished bone and joint health. We examined the effect of drop height and instruction on knee loading during a drop-landing task and proposed a task that makes use of drop heights that may be appropriate for rehabilitation purposes and functional in daily life to examine transient knee joint loads. METHODS: Twenty males (22...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28101670/recombination-correlates-with-synaptonemal-complex-length-and-chromatin-loop-size-in-bovids-insights-into-mammalian-meiotic-chromosomal-organization
#8
Aurora Ruiz-Herrera, Miluse Vozdova, Jonathan Fernández, Hana Sebestova, Laia Capilla, Jan Frohlich, Covadonga Vara, Adrià Hernández-Marsal, Jaroslav Sipek, Terence J Robinson, Jiri Rubes
Homologous chromosomes exchange genetic information through recombination during meiosis, a process that increases genetic diversity, and is fundamental to sexual reproduction. In an attempt to shed light on the dynamics of mammalian recombination and its implications for genome organization, we have studied the recombination characteristics of 112 individuals belonging to 28 different species in the family Bovidae. In particular, we analyzed the distribution of RAD51 and MLH1 foci during the meiotic prophase I that serve, respectively, as proxies for double-strand breaks (DSBs) which form in early stages of meiosis and for crossovers...
January 18, 2017: Chromosoma
https://www.readbyqxmd.com/read/28100389/-effect-of-combination-model-on-fitting-cancer-mortality-and-prediction
#9
H M Qu, Y N Bai, F R Kui, X B Hu, H B Pei, X W Ren, X P Shen
Objective: To reduce the cancer burden in the Jinchang cohort and provide evidence for developing cancer prevention strategies and performing effectiveness evaluation in the Jinchang cohort. We are fitting thirteen years of cancer mortality data from the Jinchang cohort by using six kinds of predicting methods to compare relative fitness and to select good predicting methods for the prediction of cancer mortality trends. Methods: The mortality data of cancer in Jinchnag cohort from 2001-2013 were fitted using six kinds of predicting methods: dynamic series, linear regression, exponential smoothing, autoregressive integrated moving average (ARIMA) model, grey model (GM), and Joinpoint regression...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100095/shoulder-kinetics-during-start-up-and-propulsion-with-a-manual-wheelchair-within-the-initial-phase-of-uninstructed-training
#10
Samuel Hybois, Alice Siegel, Joseph Bascou, Nicolas Eydieux, Philippe Vaslin, Hélène Pillet, Pascale Fodé, Christophe Sauret
PURPOSE: Wheelchair locomotion is constraining for the upper limbs and involves a set of motor tasks that need to be learnt by a novice user. To understand this integration process, we investigated the evolution of shoulder kinetics during start-up and propulsion within the initial phase of low-intensity uninstructed training. MATERIALS AND METHODS: Seventeen novice able-bodied subjects performed a 120-min uninstructed practice distributed over 4 weeks. During the initial and final sessions, upper limbs kinematics and hand-rim kinetics were continuously collected...
January 19, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28100050/charge-carrier-hopping-dynamics-in-homogeneously-broadened-pbs-quantum-dot-solids
#11
Rachel H Gilmore, Elizabeth M Y Lee, Mark C Weidman, Adam P Willard, William A Tisdale
Energetic disorder in quantum dot solids adversely impacts charge carrier transport in quantum dot solar cells and electronic devices. Here, we use ultrafast transient absorption spectroscopy to show that homogeneously broadened PbS quantum dot arrays (σhom(2):σinh(2)>19:1, σinh/kBT<0.4) can be realized if quantum dot batches are sufficiently monodisperse (δ ≲ 3.3%). Homogeneous linewidth is found to be an inverse function of quantum dot size, monotonically increasing from ~25 meV for the largest quantum dots (5...
January 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28099162/thermography-based-blood-flow-imaging-in-human-skin-of-the-hands-and-feet-a-spectral-filtering-approach
#12
A A Sagaidachnyi, A V Fomin, D A Usanov, A V Skripal
The determination of the relationship between skin blood flow and skin temperature dynamics is the main problem in thermography-based blood flow imaging. Oscillations in skin blood flow are the source of thermal waves propagating from micro-vessels toward the skin's surface, as assumed in this study. This hypothesis allows us to use equations for the attenuation and dispersion of thermal waves for converting the temperature signal into the blood flow signal, and vice versa. We developed a spectral filtering approach (SFA), which is a new technique for thermography-based blood flow imaging...
January 18, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28098324/ionic-screening-and-dissociation-are-crucial-for-understanding-chemical-self-propulsion-in-polar-solvents
#13
Aidan T Brown, Wilson C K Poon, Christian Holm, Joost de Graaf
Polar solvents like water support the bulk dissociation of themselves and their solutes into ions, and the re-association of these ions into neutral molecules in a dynamic equilibrium, e.g., H2O2 ⇌ H(+) + HO2(-). Using continuum theory, we study the influence of these association-dissociation reactions on the self-propulsion of colloids driven by surface chemical reactions (chemical swimmers). We find that association-dissociation reactions should have a strong influence on swimmers' behaviour, and therefore should be included in future modelling...
January 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28098297/spontaneous-assembly-of-a-hybrid-crystal-liquid-phase-in-inverse-patchy-colloid-systems
#14
Silvano Ferrari, Emanuela Bianchi, Gerhard Kahl
Materials with well-defined architectures are heavily sought after in view of their diverse technological applications. Among the desired target architectures, lamellar phases stand out for their exceptional mechanical and optical features. Here we show that charged colloids, decorated on their poles with two oppositely charged regions possess the unusual ability to spontaneously assemble in different morphologies of (semi-)ordered, layered particle arrangements which maintain their structural stability over a surprisingly large temperature range...
January 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28095693/solvation-dynamics-in-liquid-water-iii-energy-fluxes-and-structural-changes
#15
Rossend Rey, James T Hynes
In previous installments it has been shown how a detailed analysis of energy fluxes induced by electronic excitation of a solute can provide a quantitative understanding of the dominant molecular energy flow channels characterizing solvation---and in particular, hydration--- relaxation dynamics. Here this work and power approach is complemented with a detailed characterization of the changes induced by such energy fluxes. We first examine the water solvent's spatial and orientational distributions and the assorted energy fluxes in the various hydration shells of the solute to provide a molecular picture of the relaxation...
January 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28092528/low-rank-and-adaptive-sparse-signal-lassi-models-for-highly-accelerated-dynamic-imaging
#16
Saiprasad Ravishankar, Brian Moore, Raj Nadakuditi, Jeffrey Fessler
Sparsity-based approaches have been popular in many applications in image processing and imaging. Compressed sensing exploits the sparsity of images in a transform domain or dictionary to improve image recovery from undersampled measurements. In the context of inverse problems in dynamic imaging, recent research has demonstrated the promise of sparsity and low-rank techniques. For example, the patches of the underlying data are modeled as sparse in an adaptive dictionary domain, and the resulting image and dictionary estimation from undersampled measurements is called dictionary-blind compressed sensing, or the dynamic image sequence is modeled as a sum of low-rank and sparse (in some transform domain) components (L+S model) that are estimated from limited measurements...
January 10, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28091836/assessment-of-edema-using-stir-via-3d-cardiovascular-magnetic-resonance-imaging-in-patients-with-suspected-myocarditis
#17
Michael Jeserich, Bela Merkely, Pascal Schlosser, Simone Kimmel, Gabor Pavlik, Stephan Achenbach
OBJECTIVE: To evaluate three-dimensional T2-weighted fast spin echo triple inversion recovery sequences (STIR+) for the diagnosis of myocardial edema in patients with suspected early myocarditis after respiratory or gastrointestinal tract viral infection and at follow-up. MATERIALS AND METHODS: We prospectively examined 28 patients with suspected myocarditis and 37 controls matched for gender and age. An ECG-triggered STIR+ was used to cover the entire left ventricle in short-axis images with 10-mm slice thickness and no interslice gap...
January 16, 2017: Magma
https://www.readbyqxmd.com/read/28089241/dynamic-t-wave-inversions-in-the-setting-of-left-bundle-branch-block
#18
H Pendell Meyers, Stephen W Smith
We illustrate the case a patient with left bundle branch block (LBBB) and electrocardiogram (ECG) changes consistent with those described in Wellens' syndrome. The characteristic ECG findings of Wellens' syndrome identify patients who have a particularly high rate of important coronary events in the near future, however these findings have previously been described only in the setting of normal conduction. A review of Wellens' syndrome, its criteria and pathophysiology, and its proposed appearance in the setting of LBBB is presented...
December 24, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28079204/quantum-ergodicity-breaking-in-semi-classical-electron-transfer-dynamics
#19
Igor Goychuk
Can the statistical properties of single-electron transfer events be correctly predicted within a common equilibrium ensemble description? This fundamental in nanoworld question of ergodic behavior is scrutinized within a very basic semi-classical curve-crossing problem. It is shown that in the limit of non-adiabatic electron transfer (weak tunneling) well-described by the Marcus-Levich-Dogonadze (MLD) rate the answer is yes. However, in the limit of the so-called solvent-controlled adiabatic electron transfer, a profound breaking of ergodicity occurs...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28079030/neuromusculoskeletal-model-self-calibration-for-on-line-sequential-bayesian-moment-estimation
#20
Diana Ruiz Bueno, Luis Montano
OBJECTIVE: Neuromusculoskeletal models involve many subject-specific physiological parameters that need to be adjusted to adequately represent muscle properties. Traditionally, neuromusculoskeletal models have been calibrated with a forward-inverse dynamic optimization which is time-consuming and unfeasible for rehabilitation therapy. Non self-calibration algorithms have been applied to these models. To the best of our knowledge, the algorithm proposed in this work is the first on-line calibration algorithm for muscle models that allows a generic model to be adjusted to different subjects in a few steps...
January 12, 2017: Journal of Neural Engineering
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