Pavel Kolkhir, Sabine Altrichter, Riccardo Asero, Alvaro Daschner, Marta Ferrer, Ana Giménez-Arnau, Tomasz Hawro, Thilo Jakob, Tamar Kinaciyan, Arno Kromminga, George N Konstantinou, Michael Makris, Martin Metz, Per Stahl Skov, Petra Staubach, Gordon Sussman, Ke Zhang, Marcus Maurer
PURPOSE: Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. METHODS: We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against FcεRIα/IgE detected by immunoassay...
July 2021: Allergy, Asthma & Immunology Research