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Urticaria hypothyroidism

Allen P Kaplan
BACKGROUND: Chronic Spontaneous Urticaria (CSU) is an endogenous disorder that is strongly associated with autoimmunity, particularly with immunoglobulin G (IgG) antibody to the alpha subunit of the IgE receptor seen in 35-40% of patients. Basophils and cutaneous mast cells can be activated and lead to a late-phase-like perivascular infiltration about small venules and hive formation. METHODS: Review of current literature. RESULTS: Antibody to thyroid antigens are seen in 25% of patients; a small fraction of these may be clinically hypothyroid (Hashimoto's Thyroiditis)...
May 1, 2018: Allergy and Asthma Proceedings:
S Aurich, J C Simon, R Treudler
No abstract text is available yet for this article.
May 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
P Kolkhir, M Metz, S Altrichter, M Maurer
Patients with chronic spontaneous urticaria (CSU) are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG antithyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often elevated in CSU than those of other IgG antithyroid AAbs (strong evidence)...
October 2017: Allergy
E K Van Obberghen, M Cohen, F Rocher, C Lebrun-Frenay
Natalizumab (NTZ) is an effective treatment for patients with highly active relapsing remitting multiple sclerosis (MS). However, when the therapy must be interrupted, it is important to anticipate the withdrawal to avoid reactivation or disease rebound. Described here is the case of a 35-year-old woman, with a past history of beta thalassemia, bulimia and asthma, who was diagnosed with MS at age 26. She was treated initially with first-line subcutaneous (sc) immunomodulatory treatments. However, due to liver toxicity, interferon beta-1a sc was interrupted and replaced by glatiramer acetate treatment, which was well tolerated and used for several years...
April 2017: Revue Neurologique
Do Hun Kim, Nam Hee Sung, Ai Young Lee
BACKGROUND: Thyroid autoimmunity has been increasingly reported to be associated with chronic urticaria (CU), and the possible clinical benefit of thyroid hormone or anti-thyroid drugs in some CU patients with autoimmune thyroid disease has been studied. However, the effect of thyroid hormone or anti-thyroid drugs on clinical symptoms of CU remains unclear. OBJECTIVE: We investigated the clinical response of urticaria to the treatment of thyroid dysfunction. METHODS: Medical records of patients with CU evaluated for thyroid autoimmunity and thyroid function were collected and reviewed...
April 2016: Annals of Dermatology
Giulio Perugi, Giuseppe Quaranta, Serena Belletti, Francesca Casalini, Nicola Mosti, Cristina Toni, Liliana Dell'Osso
BACKGROUND: Patients with bipolar disorder (BD) suffer from greater physical morbidity and mortality than the general population. The aim of the present study is to explore the prevalence and clinical correlates of General Medical Conditions (GMC) in a large consecutive sample of patients with BD. METHOD: The study sample comprised of 347 patients who met DSM-IV-TR criteria for BD I (n=207, 59.7%), BD II or Cyclothymic Disorder (n=140, 40.3). Diagnostic information was collected by means of the Structured Clinical Interview for DSM-IV Axis I Disorders- Clinical Version (SCID-I), and information about personal and family history were collected by the Semi-Structured Interview for Mood Disorder-Revised (SIMD-R)...
January 1, 2015: Journal of Affective Disorders
Ruy Felippe Brito Gonçalves Missaka, Henrique Costa Penatti, Maria Regina Cavariani Silvares, Célia Regina Nogueira, Gláucia Maria Ferreira da Silva Mazeto
CONTEXT AND OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN AND SETTING: Case-control study including 115 patients with CIU at a tertiary public institution...
2012: São Paulo Medical Journal, Revista Paulista de Medicina
Carla Irani, Mouin Jammal, Gerard Asmar, Hanine Hajj, Georges Halaby
GOAL: Idiopathic chronic urticaria may be associated to other auto-immune diseases, in particular thyroiditis. The goal of our study is to show that this association is higher than the incidence of auto-immune thyroiditis in the general population. METHODS: It is a retrospective observational study including 90 patients with chronic urticaria. We calculated the proportion of patients having associated auto-immune thyroiditis based on a level of anti-TPO >220 mUI/ml...
April 2012: Le Journal Médical Libanais. the Lebanese Medical Journal
Tara F Carr, Carol A Saltoun
Urticaria, also known as hives, may affect up to 20% of the population at some time in their lives. Urticaria is characterized by extreme pruritus and described as erythematous, raised, circumscribed lesions with central pallor that blanch with pressure. The pathogenesis of urticaria involves mast cell activation, with subsequent release of histamine and other vasoactive mediators, leading to increased vascular permeability of postcapillary venules and development of edema, erythema, and pruritus. Urticaria is closely associated with angioedema in 40% of individuals; ∼10% of patients experience angioedema without urticaria...
May 2012: Allergy and Asthma Proceedings:
E Levy, B Neven, N Entz-Werle, B Cribier, D Lipsker
BACKGROUND: Foxn1 transcription factor deficit leads to immune deficiency, with hair and nail abnormalities. We report the case of a patient also presenting localized leucoderma. CASE REPORT: A 3-year-old boy underwent thymus transplantation at the age of 9 months for Foxn1 deficiency. He had developed urticaria and autoimmune hypothyroidism after thymus grafting. On examination, he had universal non-scarring alopecia, nail changes (atrophy, partial onycholysis and longitudinal grooves) and leucoderma on both big toes...
June 2012: Annales de Dermatologie et de Vénéréologie
Ronit Confino-Cohen, Gabriel Chodick, Varda Shalev, Moshe Leshno, Oded Kimhi, Arnon Goldberg
BACKGROUND: Chronic urticaria (CU) is a common disease in which most cases were considered to be idiopathic. Recent evidence indicates that at least a subset of cases of chronic idiopathic urticaria are autoimmune in origin. OBJECTIVE: We aimed to characterize the association between CU, autoimmune diseases, and autoimmune/inflammatory serologic markers in a large unselected population. METHODS: Data on 12,778 patients given a diagnosis of CU by either allergy or dermatology specialists during 17 years in a large health maintenance organization in Israel were collected...
May 2012: Journal of Allergy and Clinical Immunology
Eli Magen, Joseph Mishal
Autoimmune thyroiditis (AT) is more prevalent in patients with chronic idiopathic urticaria CIU) than in the general population. Previous small studies without any controlled comparison reported that CIU remits in patients with CIU and AT treated with L-thyroxine. To determine whether l-thyroxine treatment can improve the clinical course of CIU in patients with the co-occurrence of AT and CIU. A total of 749 patients with CIU were retrospectively studied. Clinical and laboratory evaluation and classification of chronic urticaria were performed according to the EAACI/GA(2)LEN/EDF/WAO guidelines...
January 2012: International Journal of Dermatology
Zaheera Saadia, Abdullateef A Alzolibani, Ahmad Al Robaee, Hani A Al Shobaili, Ahmad A Settin
OBJECTIVES: Many of the signs of hypothyroidism, affect the skin as well as the genital system of affected female cases. The aim of this study is to highlight the presenting dermatologic and gynecologic manifestations of firstly-diagnosed hypothyroid females. PATIENTS AND METHODS: This is a case control study that included 150 patients presenting for gynecological consultation. Out of them, 60 were affected with hypothyroidism and 90 were euthyroid based on clinical and laboratory investigation backgrounds...
November 2010: International Journal of Health Sciences
Marcello Bagnasco, Paola L Minciullo, Giovanna S Saraceno, Sebastiano Gangemi, Salvatore Benvenga
BACKGROUND: Chronic urticaria is a common clinical condition whose etiology, in about 75% of cases, is unknown and is therefore called chronic idiopathic urticaria (CIU). A link between CIU and autoimmune thyroid diseases was proposed several decades ago. Here we review this topic. SUMMARY: Several studies have been performed to determine if and to what degree there is an association between CIU and autoimmune thyroid diseases, particularly autoimmune thyroiditis...
April 2011: Thyroid: Official Journal of the American Thyroid Association
Iram Saddiqa Aamir, Shoaib Tauheed, Farrukh Majid, Alina Atif
OBJECTIVE: To determine the frequency of autoimmune thyroid disease in diagnosed cases of chronic urticaria (CU) and the association between hypothyroidism and chronic urticaria if any. STUDY DESIGN: Non-interventional, descriptive study. PLACE AND DURATION OF STUDY: Department of Physiology, Dow University of Health Sciences, Karachi, from December 2004 to January 2006. METHODOLOGY: The patients were selected from Department of Dermatology and Medical Units of Civil Hospital, Jinnah Postgraduate Medical Centre, the Aga Khan Hospital and community clinics...
March 2010: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
S Kiyici, O O Gul, E B Baskan, S Hacioglu, F Budak, E Erturk, S Imamoglu
BACKGROUND: Screening for thyroid autoimmunity in patients with chronic idiopathic urticaria (CIU) is generally recommended. However, there are not yet sufficient data as to whether levothyroxine treatment is beneficial for the clinical symptoms of CIU in patients with thyroid autoimmunity. AIM: We investigated the effect of levothyroxine treatment on clinical symptoms and serum tumour necrosis factor (TNF)-alpha, interleukin (IL)-10 and interferon (IFN)-gamma levels in euthyroid patients with CIU and thyroid autoimmunity...
August 2010: Clinical and Experimental Dermatology
Brian M Wolpin, Peter F Weller, Joel T Katz, Bruce D Levy, Joseph Loscalzo
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. Stage. A 52-year-old man presented to the..
October 1, 2009: New England Journal of Medicine
A P Kaplan, M Greaves
Chronic urticaria is defined as the presence of urticaria (hives) for at least 6 weeks with the assumption that it occurs daily or close to it. If we eliminate physical urticarias and urticarial vasculitis from consideration, the remainder can be divided into autoimmune chronic urticaria (45%) and idiopathic chronic urticaria (55%). The autoimmune subgroup is associated with the IgG anti-IgE receptor alpha subunit in 35-40% of patients and IgG anti-IgE in an additional 5-10%. These autoantibodies have been shown to activate blood basophils and cutaneous mast cells in vitro with augmentation of basophil activation by complement and release of C5a, in particular...
June 2009: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Sölen Artantaş, Ulker Gül, Arzu Kiliç, Serdar Güler
BACKGROUND: In cases of thyroid diseases, many of the symptoms arise on the skin. In this study, we aimed to detect and compare the skin findings and accompanying dermatoses of patients with thyroid diseases. MATERIALS AND METHODS: 220 patients with thyroid diseases, who did not have any medical cure, and 90 healthy individuals as a control group attended our study. All of the cases were examined, and the skin findings and/or dermatoses were recorded. The skin findings in the patients and the control group were compared statistically...
March 2009: European Journal of Internal Medicine
Iram Siddiqa Aamir, Shoaib Tauheed, Farrukh Majeed, Alina Atif
OBJECTIVE: To determine the frequencies of serum antithyroglobulin and antimicrosomal autoantibodies in female patients with chronic urticaria, and the association between thyroid autoantibodies and chronic urticaria, if any. STUDY DESIGN: Non-interventional, case-control analytic study. PLACE AND DURATION OF STUDY: This study was carried out by the Department of Physiology, Dow University of Health Sciences, Karachi, from December 2004 to January 2006 on patients selected from Department of Dermatology and Medical Units of Civil Hospital, Jinnah Postgraduate Medical Centre and The Aga Khan University Hospital, Karachi and from the Community Clinics in Karachi...
August 2008: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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