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JOURNAL ARTICLE
Abdallah Damin Abukhalil, Haya Alyazouri, Reem Alsheikh, Hadeel Kahla, Minna Mousa, Hosniyeh Ladadweh, Ni'meh Al-Shami, Yousef Sahoury, Hani Naseef, Abdullah Rabba
BACKGROUND: Acute kidney injury (AKI) is a major medical problem affecting patients' quality of life and healthcare costs. OBJECTIVES: This study evaluated the severity, risk factors, and outcomes of patients diagnosed with acute kidney injury (AKI), including community-acquired AKI (CA-AKI) and hospital-acquired AKI (HA-AKI), who were admitted to tertiary institutions in Palestine. METHODS: This retrospective cross-sectional study was conducted at multiple tertiary care hospitals in Palestine by reviewing patient charts from January 2020 to March 2023...
2024: TheScientificWorldJournal
#2
JOURNAL ARTICLE
Ghada Ankawi, Sean M Bagshaw, Rinaldo Bellomo, Ian Baldwin, Rajit Basu, Gabriella Bottari, Vincenzo Cantaluppi, William Clark, Silvia De Rosa, Lui G Forni, Dana Fuhrman, Stuart Goldstein, Hernando Gomez, Faeq Husain-Syed, Michael Joannidis, Kianoush Kashani, Anna Lorenzin, Ravindra Mehta, Patrick T Murray, Ragi Murugan, Marlies Ostermann, Neesh Pannu, Vedran Premuzic, John Prowle, Thiago Reis, Thomas Rimmelé, Claudio Ronco, Mitch Rosner, Antoine Schneider, Emily See, Danielle Soranno, Gianluca Villa, Adam Whaley-Connell, Alexander Zarbock
Adsorption-based extracorporeal therapies have been subject to technical developments and clinical application for close to five decades. More recently, new technological developments in membrane and sorbent manipulation have made it possible to deliver more biocompatible extracorporeal adsorption therapies to patients with a variety of conditions. There are several key rationales based on physicochemical principles and clinical considerations that justify the application and investigation of such therapies as evidenced by multiple ex-vivo, experimental, and clinical observations...
April 15, 2024: Nephrology, Dialysis, Transplantation
#3
JOURNAL ARTICLE
Makoto Yamaguchi, Hirokazu Sugiyama, Akimasa Asai, Fumiya Kitamura, Hironobu Nobata, Hiroshi Kinashi, Takayuki Katsuno, Shogo Banno, Yasuhiko Ito, Takahiro Imaizumi, Masahiko Ando, Yoko Kubo, Maeda Keisuke, Yuria Ishida, Naoharu Mori, Takuji Ishimoto
OBJECTIVE: The clinical impact of malnutrition based on the Global Leadership Initiative on Malnutrition (GLIM) criteria in patients with kidney dysfunction remains poorly understood. This study investigated the usefulness of GLIM criteria for malnutrition predicting mortality in patients with kidney dysfunction and different clinical renal states, including no kidney disease (NKD), acute kidney injury (AKI), and chronic kidney disease (CKD). METHODS: This single-center retrospective cohort study included 6,712 patients aged ≥18 admitted between 2018 and 2019...
April 13, 2024: Journal of Renal Nutrition
#4
Yongqun Oliver He, Laura Barisoni, Avi Z Rosenberg, Peter Robinson, Alexander D Diehl, Yichao Chen, Jimmy P Phuong, Jens Hansen, Bruce W Herr, Katy Börner, Jennifer Schaub, Nikki Bonevich, Ghida Arnous, Saketh Boddapati, Jie Zheng, Fadhl Alakwaa, Pinaki Sarder, William D Duncan, Chen Liang, M Todd Valerius, Sanjay Jain, Ravi Iyengar, Jonathan Himmelfarb, Matthias Kretzler
Many data resources generate, process, store, or provide kidney related molecular, pathological, and clinical data. Reference ontologies offer an opportunity to support knowledge and data integration. The Kidney Precision Medicine Project (KPMP) team contributed to the representation and addition of 329 kidney phenotype terms to the Human Phenotype Ontology (HPO), and identified many subcategories of acute kidney injury (AKI) or chronic kidney disease (CKD). The Kidney Tissue Atlas Ontology (KTAO) imports and integrates kidney-related terms from existing ontologies (e...
April 2, 2024: bioRxiv
#5
JOURNAL ARTICLE
Paweł Wrona, Katarzyna Sawczyńska, Dominik Wróbel, Kaja Zdrojewska, Mateusz Giełczyński, Paweł Mizera, Paweł Brzegowy, Tadeusz Popiela, Agnieszka Słowik, Marcin Krzanowski
INTRODUCTION: Acute kidney injury (AKI) seems to worsen the prognosis of acute ischaemic stroke (AIS) patients treated with mechanical thrombectomy (MT). At the same time, the procedure of MT increases AKI risk by iodinated contrast use. Identification of factors predisposing to AKI after MT is important for recognizing vulnerable patients and successful prevention. AIM: To identify factors associated with the occurrence of AKI during hospitalization in MT-treated AIS patients...
March 2024: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
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JOURNAL ARTICLE
Chariclia Paradissis, Neil Cottrell, Ian D Coombes, William Y S Wang, Michael A Barras
Introduction The contribution of medication harm to rehospitalisation and adverse patient outcomes after an acute myocardial infarction (AMI) needs exploration. Rehospitalisation is costly to both patients and the healthcare facility. Following an AMI, patients are at risk of medication harm as they are often older, have multiple comorbidities and polypharmacy. This study aimed to quantify and evaluate medication harm causing unplanned rehospitalisation after an AMI. Methods This was a retrospective cohort study of patients discharged from a quaternary hospital post-AMI...
April 12, 2024: Cardiology
#7
REVIEW
Lauren E Lee, Tomohito Doke, Dhanunjay Mukhi, Katalin Susztak
Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and proteinuria, contribute to this excess lipid build-up and exacerbate kidney disease development. Recent studies have also highlighted the role of increased de novo lipogenesis in kidney fibrosis. The defect in fatty acid oxidation will cause energy starvation...
April 11, 2024: Kidney International
#8
REVIEW
Lara Fabiana Luz Malheiro, Mariana Masimessi Fernandes, Caroline Assunção Oliveira, Isadora de Souza Barcelos, Ana Jullie Veiga Fernandes, Bruna Santos Silva, Júlia Spínola Ávila, Telma de Jesus Soares, Liliany Souza de Brito Amaral
Regular exercise training can lead to several health benefits, reduce mortality risk, and increase life expectancy. On the other hand, a sedentary lifestyle is a known risk factor for chronic diseases and increased mortality. Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a significant global health problem, affecting millions of people worldwide. The progression from AKI to CKD is well-recognized in the literature, and exercise training has emerged as a potential renoprotective strategy...
April 11, 2024: Life Sciences
#9
JOURNAL ARTICLE
Huailiang Wu, Liyan Wang, Peng Kang, Xiangjun Zhou, Wei Li, Zhongyuan Xia
BACKGROUND: Renal ischemia-reperfusion is the primary cause of acute kidney injury (AKI). Clinically, most patients who experience ischemia-reperfusion injury eventually progress gradually to renal fibrosis and chronic kidney disease (CKD). However, the underlying mechanism for AKI to CKD transition remain absent. Our study demonstrated that the downregulation of sirtuin 1 (Sirt1)-mediated fatty acid oxidation (FAO) facilitates IRI-induced renal fibrosis. METHODS: The IRI animal model was established, and ribonucleic acid (RNA) sequencing was used to explore potential differentially expressed genes (DEGs) and pathways...
April 11, 2024: International Immunopharmacology
#10
JOURNAL ARTICLE
Yunwei Lu, Ziyan Xiao, Xiujuan Zhao, Yingjiang Ye, Shu Li, Fuzheng Guo, Haiyan Xue, Fengxue Zhu
BACKGROUND: Acute kidney injury (AKI) is recognized as a common complication following cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Characterized by prolonged renal function impairment, acute kidney disease (AKD) is associated with a higher risk of chronic kidney disease (CKD) and mortality. METHODS: From January 2018 to December 2021, 158 patients undergoing CRS-HIPEC were retrospectively reviewed. Patients were separated into non-AKI, AKI, and AKD cohorts...
December 2024: Renal Failure
#11
JOURNAL ARTICLE
Lonnie Pyne, Andrew Smyth, Amber O Molnar, Paul Moayyedi, Eva Muehlhofer, Salim Yusuf, John Eikelboom, Jacqueline Bosch, Michael Walsh
BACKGROUND: Observational studies have found an association between proton pump inhibitor (PPI) use and worsening kidney function. It is unclear whether these associations are causal.We conducted post-hoc analyses to determine the effect of pantoprazole on kidney function using data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial, a 17,598 participant randomized trial comparing pantoprazole (8,791) to placebo (8,807). METHODS: The primary outcome was the rate of change of estimated glomerular filtration rate (eGFR)...
April 11, 2024: Journal of the American Society of Nephrology: JASN
#12
JOURNAL ARTICLE
Sefa Burak Çam, Eda Çiftci, Nazlıhan Gürbüz, Bülent Altun, Petek Korkusuz
BACKGROUND: Acute hypoxic proximal tubule (PT) injury and subsequent maladaptive repair present high mortality and increased risk of acute kidney injury (AKI) - chronic kidney disease (CKD) transition. Human bone marrow mesenchymal stem cell-derived exosomes (hBMMSC-Exos) as potential cell therapeutics can be translated into clinics if drawbacks on safety and efficacy are clarified. Here, we determined the real-time effective dose and treatment window of allogeneic hBMMSC-Exos, evaluated their performance on the structural and functional integrity of 3D microfluidic acute hypoxic PT injury platform...
April 10, 2024: Stem Cell Research & Therapy
#13
JOURNAL ARTICLE
Jakub Klimkiewicz, Anna Grzywacz, Andrzej Michałowski, Mateusz Gutowski, Kamil Paryż, Ewelina Jędrych, Arkadiusz Lubas
Background : Acute kidney injury (AKI) is associated with substantial mortality. In this case-control study, we analyzed the impacts of AKI and chronic kidney disease (CKD) on outcomes in a group of 323 patients with severe COVID-19. The correlation of clinical and laboratory data with AKI and CKD was also analyzed. Methods: A retrospective case-control study was conducted among AKI, CKD, and normal kidney function (NKF) groups hospitalized in a COVID-19 center in 2021. Results: AKI patients had higher in-hospital mortality (55...
March 5, 2024: Journal of Clinical Medicine
#14
JOURNAL ARTICLE
Erik Hansson, Kristina Jakobsson, Jason R Glaser, Catharina Wesseling, Denis Chavarría, Rebekah A I Lucas, David H Wegman
BACKGROUND: Mesoamerican sugarcane cutters are at a high risk of chronic kidney disease of non-traditional origin, a disease likely linked to heat-related acute kidney injury (AKI). Studies in general populations have described a positive association between high environmental temperatures and clinically assessed kidney outcomes, but there are no studies in occupational settings. METHOD: We accessed routine records of clinically diagnosed AKI (AKI-CD) and wet bulb globe temperatures (WBGT) at a large Nicaraguan sugarcane plantation and modeled the relationship between these using negative binomial regression...
April 9, 2024: Workplace Health & Safety
#15
JOURNAL ARTICLE
Yen-Liang Yeh, Chien-Ming Lai, Hui-Pu Liu
BACKGROUND: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are associated with unfavorable outcomes following coronary artery bypass grafting (CABG). The purpose of this study was to compare in-hospital outcomes of patients with COPD alone versus OSA-COPD overlap after CABG. METHODS: Data of adults ≥ 18 years old with COPD who received elective CABG between 2005 and 2018 were extracted from the US Nationwide Inpatient Sample (NIS)...
April 8, 2024: BMC Pulmonary Medicine
#16
JOURNAL ARTICLE
Yuan Ren, Zuoyuan Wang, Li You, Jie Zhou, Haowen Huang, Sansi Chang, Yuanhao Wu, Jun Xue
BACKGROUND: Inflammation is crucial in the development of AKI and subsequent CKD following renal ischemia-reperfusion (IR) injury. Gut microbiota metabolites trigger inflammation and affect IR-induced renal damage. Yet, the driving factors and mechanisms are unclear. Trimethylamine N-oxide (TMAO), a gut-derived choline metabolite, is a strong pro-inflammatory factor that increases in patients with AKI and CKD. We hypothesized that TMAO can promote renal injury caused by IR. METHODS: Mice subjected to unilateral renal IR to induce AKI and CKD were fed a high-choline diet to observe the effects of TMAO on kidney inflammation, fibrosis, and macrophage dynamics...
April 8, 2024: Nephrology, Dialysis, Transplantation
#17
JOURNAL ARTICLE
Debora M Hofer, Livio Ruzzante, Jan Waskowski, Anna S Messmer, Carmen A Pfortmueller
BACKGROUND: Fluid accumulation (FA) is known to be associated with acute kidney injury (AKI) during intensive care unit (ICU) stay but data on mid-term renal outcome is scarce. The aim of this study was to investigate the association between FA at ICU day 3 and major adverse kidney events in the first 30 days after ICU admission (MAKE30). METHODS: Retrospective, single-center cohort study including adult ICU patients with sufficient data to compute FA and MAKE30...
April 8, 2024: Annals of Intensive Care
#18
REVIEW
Fatemeh Jahanshahi, Seyed Behnam Jazayeri, Mohammad Mirahmadi Eraghi, Leonardo Oliveira Reis, Mahtab Hamidikia, Shayan Amiri, Seyed Mohammad Kazem Aghamir
Studies showed that the respiratory is not the only system affected by coronavirus 2, while cardiovascular, digestive, and nervous systems, as well as essential organs such as the kidneys, can be affected by this virus. In this review, we have studied the epidemiology, clinical, and laboratory findings on COVID-19 infection renal involvement, mortality, physiopathology, remaining renal sequels after recovery, underlying renal disease, and renal injury due to its treatment. Also, protective measures for kidney injury are explained in three levels...
2024: Open Medicine (Warsaw, Poland)
#19
JOURNAL ARTICLE
S H Ooi, K P Ng, Pavai Sthaneshwar, S K Lim, P Y Khor, J Y Lim, W S Siow, K W Lim, Muhummad Azlan
BACKGROUND: The commonest indication for hospitalization in COVID-19 patients is hypoxemia or severe respiratory symptoms. However, COVID-19 disease may result in extrapulmonary complications including kidney-related pathology. The reported incidence of renal involvement related to COVID infection varies based on geographical location. OBJECTIVE: This study aimed to assess the incidence rate of AKI in hospitalized COVID-19 patients and identify risk factors and prognostic predictors...
April 5, 2024: BMC Nephrology
#20
EDITORIAL
Rakhi Maiwall, Satender Pal Singh, Paolo Angeli, Richard Moreau, Aleksander Krag, Virender Singh, Ashwani K Singal, S S Tan, Puneet Puri, Mamun Mahtab, George Lau, Qin Ning, Manoj Kumar Sharma, P N Rao, Dharmesh Kapoor, Subhash Gupta, Ajay Duseja, Manav Wadhawan, Dinesh Jothimani, Sanjiv Saigal, Sunil Taneja, Akash Shukla, Pankaj Puri, Deepak Govil, Gaurav Pandey, Kaushal Madan, C E Eapen, Jaya Benjamin, Ashok Chowdhury, Shweta Singh, Vaishali Salao, Jin Mo Yang, Saeed Hamid, Shalimar, Sanjiv Jasuja, Anand V Kulkarni, Madund A Niriella, Harsh Vardhan Tevethia, Vinod Arora, R P Mathur, Akash Roy, Ankur Jindal, Neeraj Saraf, Nipun Verma, Arka De, Narendra S Choudhary, Rohit Mehtani, Phool Chand, Omkar Rudra, Shiv Kumar Sarin
Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a high risk of short-term early death. The main causes of organ failure in these patients are bacterial infections and systemic inflammation, both of which can be severe. For the majority of these patients, a prompt liver transplant is still the only effective course of treatment. Kidneys are one of the most frequent extrahepatic organs that are affected in patients with ACLF, since acute kidney injury (AKI) is reported in 22...
April 5, 2024: Hepatology International
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