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Maria A Parker, Dongseok Choi, Laura R Erker, Mark E Pennesi, Paul Yang, Elvira N Chegarnov, Peter N Steinkamp, Catherine L Schlechter, Claire-Marie Dhaenens, Saddek Mohand-Said, Isabelle Audo, Jose Sahel, Richard G Weleber, David J Wilson
PURPOSE: The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of Stargardt Disease (STGD) participating in the SAR422459 (NCT01367444) gene therapy clinical trial. METHODS: Twenty-two participants, aged 24 to 66, diagnosed with advanced forms of STGD, with at least one pathogenic ABCA4 mutation on each chromosome participating in the SAR422459 (NCT01367444) gene therapy clinical trial, were screened over three visits within 3 weeks or less...
October 2016: Translational Vision Science & Technology
Jun Wang, Louise B Thingholm, Jurgita Skiecevičienė, Philipp Rausch, Martin Kummen, Johannes R Hov, Frauke Degenhardt, Femke-Anouska Heinsen, Malte C Rühlemann, Silke Szymczak, Kristian Holm, Tönu Esko, Jun Sun, Mihaela Pricop-Jeckstadt, Samer Al-Dury, Pavol Bohov, Jörn Bethune, Felix Sommer, David Ellinghaus, Rolf K Berge, Matthias Hübenthal, Manja Koch, Karin Schwarz, Gerald Rimbach, Patricia Hübbe, Wei-Hung Pan, Raheleh Sheibani-Tezerji, Robert Häsler, Philipp Rosenstiel, Mauro D'Amato, Katja Cloppenborg-Schmidt, Sven Künzel, Matthias Laudes, Hanns-Ulrich Marschall, Wolfgang Lieb, Ute Nöthlings, Tom H Karlsen, John F Baines, Andre Franke
Human gut microbiota is an important determinant for health and disease, and recent studies emphasize the numerous factors shaping its diversity. Here we performed a genome-wide association study (GWAS) of the gut microbiota using two cohorts from northern Germany totaling 1,812 individuals. Comprehensively controlling for diet and non-genetic parameters, we identify genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D receptor)...
November 2016: Nature Genetics
Elisabeth Schrumpf, Martin Kummen, Laura Valestrand, Thomas U Greiner, Kristian Holm, Velmurugesan Arulampalam, Henrik M Reims, John Baines, Fredrik Bäckhed, Tom H Karlsen, Richard S Blumberg, Johannes R Hov, Espen Melum
BACKGROUND & AIMS: A strong association between human inflammatory biliary diseases and gut inflammation has led to the hypothesis that gut microbes and lymphocytes activated in the intestine play a role in biliary inflammation. The NOD.c3c4 mouse model develops spontaneous biliary inflammation in extra- and intrahepatic bile ducts. We aimed to clarify the role of the gut microbiota in the biliary disease of NOD.c3c4 mice. METHODS: We sampled cecal content and mucosa from conventionally raised (CONV-R) NOD...
October 5, 2016: Journal of Hepatology
Dexiang Wang, Chunsheng Wang, Yuan Zhang, Chenggang Liu
Three new glass sponge species of the family Pheronematidae are described in this study. Specimens were sampled in the northwestern Pacific Ocean during cruise DY125-35I expedition (July-August, 2014) conducted by the China Ocean Mineral Resources R&D Association. All samples were collected by the Chinese manned submersible Jiaolong HOV at a depth of 1627-2897 m. The three species belonging to three genera of the same family were observed, i.e., Platylistrum subviridum sp. nov. Poliopogon canaliculatus sp. nov...
September 29, 2016: Zootaxa
Johannes R Hov, Kirsten M Boberg, Eli Taraldsrud, Mette Vesterhus, Maria Boyadzhieva, Inger Camilla Solberg, Erik Schrumpf, Morten H Vatn, Benedicte A Lie, Øyvind Molberg, Tom H Karlsen
BACKGROUND&AIMS: The strongest genetic risk factors in primary sclerosing cholangitis (PSC) are encoded in the HLA complex. Anti-neutrophil cytoplasmic antibodies (ANCA) have been reported in up to 94% of PSC patients, but their clinical significance and immunogenetic basis are ill-defined. We aimed to characterize clinical and genetic associations of ANCA in PSC. METHODS: ANCA were analyzed with indirect immunofluorescence in 241 Norwegian PSC patients. HLA-B and HLA-DRB1 genotyping was performed in the patients and in 368 healthy controls...
August 25, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Tuva Sandsdalen, Vigdis Abrahamsen Grøndahl, Reidun Hov, Sevald Høye, Ingrid Rystedt, Bodil Wilde-Larsson
BACKGROUND: Patients' perceptions of care quality within and across settings are important for the further development of palliative care. The aim was to investigate patients' perceptions of palliative care quality within settings, including perceptions of care received and their subjective importance, and contrast palliative care quality across settings. METHOD: A cross-sectional study including 191 patients in late palliative phase (73 % response rate) admitted to hospice inpatient care, hospice day care, palliative units in nursing homes, and home care was conducted, using the Quality from the Patients' Perspective instrument-palliative care (QPP-PC)...
August 24, 2016: BMC Palliative Care
Ingrid Hov Odsæter, Arne Åsberg, Eszter Vanky, Siv Mørkved, Signe Nilssen Stafne, Kjell Åsmund Salvesen, Sven Magnus Carlsen
BACKGROUND: Gestational diabetes mellitus (GDM) increases the risk for preeclampsia and macrosomia. GDM is conventionally diagnosed by an oral glucose tolerance test (OGTT). Hemoglobin A1c (HbA1c) is a marker for the average glucose level the last 2-3 months. We aimed to study if HbA1c alone or in combination with patient characteristics can be used to screen for GDM and reduce the number of OGTTs, and whether it could predict preeclampsia or birth weight. METHODS: 855 women from a previous study on the effect of exercise on GDM prevalence were eligible, whereof 677 were included...
2016: Diabetology & Metabolic Syndrome
Sebastian Torben Jendrek, Daniel Gotthardt, Thomas Nitzsche, Laila Widmann, Tobias Korf, Maike Anna Michaels, Karl-Heinz Weiss, Evaggelia Liaskou, Mette Vesterhus, Tom Hemming Karlsen, Swantje Mindorf, Peter Schemmer, Florian Bär, Bianca Teegen, Torsten Schröder, Marc Ehlers, Christoph Matthias Hammers, Lars Komorowski, Hendrik Lehnert, Klaus Fellermann, Stefanie Derer, Johannes Roksund Hov, Christian Sina
OBJECTIVE: Pancreatic autoantibodies (PABs), comprising antibodies against glycoprotein 2 (anti-GP2), are typically associated with complicated phenotypes in Crohn's disease, but have also been observed with variable frequencies in patients with UC. In a previous study, we observed a high frequency of primary sclerosing cholangitis (PSC) in patients with anti-GP2-positive UC. We therefore aimed to characterise the role of anti-GP2 in PSC. DESIGN: In an evaluation phase, sera from 138 well-characterised Norwegian patients with PSC were compared with healthy controls (n=52), and patients with UC without PSC (n=62) for the presence of PABs by indirect immunofluorescence...
July 12, 2016: Gut
Arne Åsberg, Harald Johnsen, Gustav Mikkelsen, Gunhild Garmo Hov
BACKGROUND: The analytical performance of qualitative and semi-quantitative tests is usually studied by calculating the fraction of positive results after replicate testing of a few specimens with known concentrations of the analyte. We propose using probit regression to model the probability of positive results as a function of the analyte concentration, based on testing many specimens once with a qualitative and a quantitative test. METHODS: We collected laboratory data where urine specimens had been analyzed by both a urine albumin ('protein') dipstick test (Combur-Test strips) and a quantitative test (BN ProSpec System)...
July 6, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
Aida Kapic Lunder, Johannes Roksund Hov, Arne Borthne, Jostein Gleditsch, Glenn Johannesen, Knut Tveit, Ellen Viktil, Magne Henriksen, Øistein Hovde, Gert Huppertz-Hauss, Ole Høie, Marte Lie Høivik, Iril Monstad, Inger Camilla Solberg, Jørgen Jahnsen, Tom Hemming Karlsen, Bjørn Moum, Morten Vatn, Anne Negård
BACKGROUND & AIMS: The prevalence of primary sclerosing cholangitis (PSC) among patients with inflammatory bowel disease (IBD) is unclear. Patients with IBD might be screened for PSC using magnetic resonance cholangiography (MRC). We aimed to estimate the frequency and distribution of MRC-detected lesions that indicate PSC in patients with IBD 20 years after their initial diagnosis and to identify clinical characteristics associated with these findings. METHODS: We performed a follow-up analysis of a population-based cohort of 756 patients in South-Eastern Norway diagnosed with IBD from January 1, 1990 through December 31, 1993...
October 2016: Gastroenterology
Lukasz A Paluchowski, Håvard B Nordgaard, Asgeir Bjorgan, Håkon Hov, Sissel M Berget, Lise L Randeberg
No abstract text is available yet for this article.
October 1, 2016: Journal of Biomedical Optics
Andreas Knudsen, Thomas Emil Christensen, Kristina Thorsteinsson, Adam Ali Ghotbi, Philip Hasbak, Anne-Mette Lebech, Susanne Dam Nielsen, Johannes Roksund Hov, Rolf Berge, Rasmus Sejersten Ripa, Andreas Kjær, Marius Trøseid
No abstract text is available yet for this article.
August 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Travis B Smith, Ning Smith, Richard G Weleber
Visual field testing with standard automated perimetry produces a sparse representation of a sensitivity map, sometimes called the hill of vision (HOV), for the retina. Interpolation or resampling of these data is important for visual display, clinical interpretation, and quantitative analysis. Our objective was to compare several popular interpolation methods in terms of their utility to visual field testing. We evaluated nine nonparametric scattered data interpolation algorithms and compared their performances in normal subjects and patients with retinal degeneration...
April 22, 2016: Medical & Biological Engineering & Computing
Maren Ranhoff Hov, Christian Georg Lund
No abstract text is available yet for this article.
April 19, 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Marius Trøseid, Johannes R Hov, Torunn Kristin Nestvold, Hanne Thoresen, Rolf K Berge, Asbjørn Svardal, Knut Tore Lappegård
BACKGROUND: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of TMAO formation from carnitine is via the microbiota-dependent intermediate γ-butyrobetaine (γBB). Elevated TMAO levels are associated with cardiovascular disease (CVD), but little is known about TMAO in obesity. Given the proposed contribution of microbiota alterations in obesity and type 2 diabetes (T2D), we investigated the potential impact of obesity, lifestyle-induced weight loss, and bariatric surgery on plasma levels of TMAO, its microbiota-dependent intermediate γBB, and its diet-dependent precursors carnitine and choline...
May 2016: Metabolic Syndrome and related Disorders
Karen Roksund Hov, Jens Petter Berg, Frede Frihagen, Johan Ræder, Roanna Hall, Torgeir Bruun Wyller, Leiv Otto Watne
BACKGROUND/AIMS: Delirium is a common and serious complication in hospitalised patients and its pathophysiology is incompletely understood. We aimed to examine whether blood-cerebrospinal fluid barrier dysfunction, as measured by Q-albumin (the ratio of cerebrospinal fluid albumin to serum albumin), was associated with delirium. METHODS: In this prospective cohort study of hip fracture patients from Oslo University Hospital, Norway, serum was collected preoperatively and cerebrospinal fluid just before the onset of spinal anaesthesia...
2016: Dementia and Geriatric Cognitive Disorders
Maren Ranhoff Hov, Christian Georg Lund
No abstract text is available yet for this article.
April 5, 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
S F Jørgensen, M Trøseid, M Kummen, J A Anmarkrud, A E Michelsen, L T Osnes, K Holm, M L Høivik, A Rashidi, C P Dahl, M Vesterhus, B Halvorsen, T E Mollnes, R K Berge, B Moum, K E A Lundin, B Fevang, T Ueland, T H Karlsen, P Aukrust, J R Hov
Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency characterized by low immunoglobulin (Ig)G and IgA, and/or IgM. In addition to bacterial infections, a large subgroup has noninfectious inflammatory and autoimmune complications. We performed 16S ribosomal RNA-based profiling of stool samples in 44 CVID patients, 45 patients with inflammatory bowel disease (disease controls), and 263 healthy controls. We measured plasma lipopolysaccharide (LPS) and markers of immune cell activation (i...
November 2016: Mucosal Immunology
Andreas Wannhoff, Trine Folseraas, Maik Brune, Christian Rupp, Kilian Friedrich, Johannes Knierim, Karl Heinz Weiss, Peter Sauer, Christa Flechtenmacher, Peter Schirmacher, Wolfgang Stremmel, Johannes R Hov, Daniel N Gotthardt
BACKGROUND: Primary sclerosing cholangitis (PSC) patients are at increased risk of biliary tract cancer, and carcinoembryonic antigen (CEA) serum levels might be used for screening. OBJECTIVE: To examine cancer screening with CEA in PSC patients and analyse how serum CEA levels are affected by genetic variants of fucosyltransferase (FUT) 2 and 3. METHODS: In a retrospective cohort analysis we evaluated CEA levels in 226 PSC patients, including 19 with biliary malignancy, and investigated how FUT2 and FUT3 SNPs affected CEA levels...
February 2016: United European Gastroenterology Journal
Martin Kummen, Kristian Holm, Jarl Andreas Anmarkrud, Ståle Nygård, Mette Vesterhus, Marte L Høivik, Marius Trøseid, Hanns-Ulrich Marschall, Erik Schrumpf, Bjørn Moum, Helge Røsjø, Pål Aukrust, Tom H Karlsen, Johannes R Hov
OBJECTIVE: Gut microbiota could influence gut, as well as hepatic and biliary immune responses. We therefore thoroughly characterised the gut microbiota in primary sclerosing cholangitis (PSC) compared with healthy controls (HC) and patients with ulcerative colitis without liver disease. DESIGN: We prospectively collected 543 stool samples. After a stringent exclusion process, bacterial DNA was submitted for 16S rRNA gene sequencing. PSC and HC were randomised to an exploration panel or a validation panel, and only significant results (p<0...
February 17, 2016: Gut
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