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https://www.readbyqxmd.com/read/28059503/fused-nonacyclic-electron-acceptors-for-efficient-polymer-solar-cells
#1
Shuixing Dai, Fuwen Zhao, Qianqian Zhang, Tsz-Ki Lau, Tengfei Li, Kuan Liu, Qidan Ling, Chunru Wang, Xinhui Lu, Wei You, Xiaowei Zhan
We design and synthesize four fused-ring electron acceptors based on 6,6,12,12-tetrakis(4-hexylphenyl)-indacenobis(dithieno[3,2-b;2',3'-d]thiophene) as the electron-rich unit and 1,1-dicyanomethylene-3-indanones with 0 to 2 fluorine substituents as the electron-deficient units. These four molecules exhibit broad (550-850 nm) and strong absorption with high extinction coefficients of (2.1-2.5) ×10(5) M(-1) cm(-1). Fluorine substitution down shifts LUMO energy level, red shift absorption spectrum, and enhance electron mobility...
January 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27992080/enantioseparation-of-nine-indanone-and-tetralone-derivatives-by-hplc-using-carboxymethyl-%C3%AE-cyclodextrin-as-the-mobile-phase-additive
#2
Xiaoyu Hu, Xin Guo, Shuo Sun, Bolin Zhu, Jia Yu, Xingjie Guo
High-performance liquid chromatography (HPLC) is a powerful method in the area of chiral separation. In this study, a method of HPLC using carboxymethyl-β-cyclodextrin (CM-β-CD) as chiral selector was developed for enantioseparation of nine indanone and tetralone derivatives. The separation was performed on a conventional C18 column. The optimal mobile phase was a mixture of methanol and 0.05 mol/L phosphate buffer at pH 1.8 (55:45, v/v) containing 22.9 mmol/L CM-β-CD. Under such conditions, the resolutions of all analytes were over 1...
December 19, 2016: Chirality
https://www.readbyqxmd.com/read/27978729/silver-catalyzed-domino-reaction-of-ortho-carbonylated-alkynyl-substituted-arylaldehydes-with-conjugated-dienes-stereoselective-access-to-indanone-fused-cyclohexenes
#3
Ziping Cao, Hongbo Zhu, Xin Meng, Laijin Tian, Guang Chen, Xuejun Sun, Jinmao You
A silver-catalyzed domino reaction of ortho-carbonylated alkynyl-substituted arylaldehydes with conjugated dienes is described here. Through this reaction, the synthesis of a variety of indanone-fused cyclohexene derivatives can be achieved efficiently. The formation of these tricyclic products could involve a key Diels-Alder reaction of in situ generated indanenone dienophiles with conjugated dienes. Particularly, the products can be accomplished in a high endo/exo selective way.
December 16, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27936694/chiral-n-n-dioxide-organocatalyzed-asymmetric-electrophilic-%C3%AE-cyanation-of-%C3%AE-keto-esters-and-%C3%AE-keto-amides
#4
Baiwei Ma, Xiaobin Lin, Lili Lin, Xiaoming Feng, Xiaohua Liu
An enantioselective electrophilic α-cyanation of 1-indanone-derived β-keto esters and β-keto amides using a hypervalent iodine as the cyanide-transfer reagent was realized. A chiral N,N'-dioxide was used as the efficient bifunctional organocatalyst in the presence of inorganic base, which gave the corresponding α-cyano dicarbonyl compounds in yields of 50-99% with good enantioselectivities (87-97% ee).
December 22, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27922737/%C3%AF-conjugated-lewis-base-efficient-trap-passivation-and-charge-extraction-for-hybrid-perovskite-solar-cells
#5
Yuze Lin, Liang Shen, Jun Dai, Yehao Deng, Yang Wu, Yang Bai, Xiaopeng Zheng, Jiayu Wang, Yanjun Fang, Haotong Wei, Wei Ma, Xiao Cheng Zeng, Xiaowei Zhan, Jinsong Huang
A π-conjugated Lewis base is introduced into perovskite solar cells, namely, indacenodithiophene end-capped with 1.1-dicyanomethylene-3-indanone (IDIC), as a multifunctional interlayer which combines efficient trap-passivation and electron-extraction. Perovskite solar cells with IDIC layers yield higher photovoltages and photocurrents, and 45% enhanced efficiency compared with control devices without IDIC.
December 6, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27892638/a-new-nonfullerene-electron-acceptor-with-a-ladder-type-backbone-for-high-performance-organic-solar-cells
#6
Nailiang Qiu, Huijing Zhang, Xiangjian Wan, Chenxi Li, Xin Ke, Huanran Feng, Bin Kan, Hongtao Zhang, Qiang Zhang, Yan Lu, Yongsheng Chen
Nonfullerene acceptor FDICTF (2,9-bis(2methylene-(3-(1,1-dicyanomethylene)indanone))-7,​12-​dihydro-​4,​4,​7,​7,​12,​12-​hexaoctyl-​4H-​cyclopenta[2″,​1″:5,​6;3″,​4″:5',​6']​diindeno[1,​2-​b:1',​2'-​b']dithiophene) modified by fusing the fluorene core in a precursor, yields 10.06% high power conversion efficiency, and demonstrates that the ladder and fused core backbone in A-D-A structure molecules is an effective design strategy for high-performance nonfullerene acceptors...
November 28, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27823887/targeting-alzheimer-s-disease-by-investigating-previously-unexplored-chemical-space-surrounding-the-cholinesterase-inhibitor-donepezil
#7
Divan G van Greunen, Werner Cordier, Margo Nell, Chris van der Westhuyzen, Vanessa Steenkamp, Jenny-Lee Panayides, Darren L Riley
A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug donepezil, which is currently used for the management of mild to severe Alzheimer's disease. Two series of analogues were prepared, the first looking at the replacement of the piperidine ring in donepezil with different sized saturated N-containing ring systems and the second looking at the introduction of different linkers between the indanone and piperidine rings in donepezil...
October 20, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27731646/total-synthesis-of-coprinol
#8
Muthiah Suresh, Navin Kumar, Gorre Veeraraghavaiah, Sunit Hazra, Raj Bahadur Singh
The first synthesis of coprinol has been achieved from 2-methoxy-3,5-dimethylbenzaldehyde via the intermediacy of an indanone derivative where dialkylation, Friedel-Crafts acylation, demethylation, and regioselective formation of a primary -OH group from a chloroacetyl group are the key steps.
October 12, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27662218/2-heteroarylidene-1-indanone-derivatives-as-inhibitors-of-monoamine-oxidase
#9
Magdalena S Nel, Anél Petzer, Jacobus P Petzer, Lesetja J Legoabe
In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related to series of heterocyclic chalcone derivatives which have previously been shown to act as MAO-B specific inhibitors. The results document that the 2-heteroarylidene-1-indanones are in vitro inhibitors of MAO-B, displaying IC50 values of 0.0044-1.53μM. Although with lower potencies, the derivatives also inhibit the MAO-A isoform with IC50 values as low as 0...
September 17, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27629824/thio-and-semicarbazones-hope-in-the-search-for-treatment-of-leishmaniasis-and-chagas-disease
#10
Barbara V da Silva, Bianca N M Silva
BACKGROUND: Trypanosomiasis and leishmaniasis cause severe infections in humans and domestic animals in the tropics. Although typical diseases in Latin America, globalization and the migration of infected people has spread these diseases to countries in North America, Asia and Europe. Currently available drugs are not effective in the chronic phase, as well as causing side effects and the development of resistance. RESULTS: Among the chemical groups studied as potential anti-T...
September 9, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27578245/2-benzylidene-1-indanone-derivatives-as-inhibitors-of-monoamine-oxidase
#11
Magdalena S Nel, Anél Petzer, Jacobus P Petzer, Lesetja J Legoabe
In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 2-benzylidene-1-indanone derivatives are structurally related to a series of benzylideneindanone derivatives which has previously been found to be MAO-B inhibitors. This study finds that the 2-benzylidene-1-indanones are MAO-B specific inhibitors with IC50 values <2.74μM. Among the compounds evaluated, twelve compounds exhibited IC50<0...
October 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27565554/6-methoxy-indanone-derivatives-as-potential-probes-for-%C3%AE-amyloid-plaques-in-alzheimer-s-disease
#12
Dou-Dou Nan, Chang-Sheng Gan, Chen-Wei Wang, Jin-Ping Qiao, Xin-Meng Wang, Jiang-Ning Zhou
A series of 6-methoxy indanone derivatives was synthesized and evaluated as potential probes for β-amyloid plaque imaging in Alzheimer's disease (AD). Two derivatives (5d and 5k) displayed significant binding abilities in fluorescent staining experiments using the brain sections of AD patients. Two derivatives showed high binding affinities to β-amyloid aggregates (5j, Ki = 5.82 ± 0.19 nM) and brain homogenates of AD patients (5j, Ki = 18.96 ± 0.28 nM) in in vitro binding assay. With a log P value of 3...
November 29, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27495835/anticancer-activity-of-gallic-acid-template-based-benzylidene-indanone-derivative-as-microtubule-destabilizer
#13
Aastha Singh, Kaneez Fatima, Ankita Srivastava, Sadiya Khwaja, Dev Priya, Arjun Singh, Girish Mahajan, Sarfaraz Alam, Ajit K Saxena, D M Mondhe, Suaib Luqman, Debabrata Chanda, Feroz Khan, Arvind S Negi
Benzylidene indanones have been designed and synthesized from gallic acid, a plant phenolic acid as possible anticancer agent. The best analogue of the series, that is, 3-(3',4',5'-trimethoxyphenyl)-4,5,6-trimethoxy-2-(4˝-nitrobenzylidene)-indan-1-one (8) exhibited potent cytotoxicity (IC50 =3-10 μm) against several human cancer cell lines through microtubule destabilization (IC50 =1.54 μm) after occupying colchicine-binding site of β-tubulin. In cell cycle analysis, compound 8 exerted G2/M phase arrest in both MCF-7 and MDA-MB-231 cells and induced apoptosis...
November 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27490335/sulfoxide-based-enantioselective-nazarov-cyclization-divergent-syntheses-of-isopaucifloral%C3%A2-f-quadrangularin%C3%A2-a-and-pallidol
#14
Mei-Lin Tang, Peng Peng, Zheng-Yu Liu, Jian Zhang, Jian-Ming Yu, Xun Sun
The synthesis of enantiomerically pure 3-aryl substituted indanones is developed using an enantioselective sulfoxide-based Knoevenagel condensation/Nazarov cyclization procedure. After the reductive desulfonation of the methyl para-tolyl sulfoxide-containing chiral auxiliary under mild conditions, selected enantiomerically pure indanone is used for the divergent total syntheses of three resveratrol natural products (+)-isopaucifloral F, (+)-quadrangularin A, and (+)-pallidol.
October 4, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27355517/rapid-access-to-orthogonally-functionalized-naphthalenes-application-to-the-total-synthesis-of-the-anticancer-agent-chartarin
#15
Teresa A Unzner, Adriana S Grossmann, Thomas Magauer
We report the synthesis of orthogonally functionalized naphthalenes from simple, commercially available indanones in four steps. The developed method proceeds through a two-step process that features a thermally induced fragmentation of a cyclopropane indanone with simultaneous 1,2-chloride shift. Migration of the chloride substituent occurs in a regioselective manner to preferentially afford the para-chloronaphthol substitution pattern. The obtained naphthols are versatile building blocks that can be selectively modified and used for the efficient construction of biologically active molecules...
August 8, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27228381/synthesis-of-indole-substituted-indanones-via-palladium-ii-catalyzed-tandem-reaction-of-ortho-electron-deficient-alkynyl-substituted-aryl-aldehydes-with-indoles
#16
Jianbo Zhang, Xiuling Han, Xiyan Lu
A Pd(OAc)2-catalyzed cyclization reaction of ortho-electron-deficient alkynyl-substituted aryl aldehydes with indoles was accomplished, providing an efficient and economical way to synthesize indole-substituted indanones. The electron-withdrawing group attached to the alkyne and the nucleophilic indole play important roles in the formation of the indanone ring.
June 17, 2016: Organic Letters
https://www.readbyqxmd.com/read/27195605/tandem-bond-forming-reactions-of-1-alkynyl-ethers
#17
Thomas G Minehan
Electron-rich alkynes, such as ynamines, ynamides, and ynol ethers, are functional groups that possess significant potential in organic chemistry for the formation of carbon-carbon bonds. While the synthetic utility of ynamides has recently been expanded considerably, 1-alkynyl ethers, which possess many of the reactivity features of ynamides, have traditionally been far less investigated because of concerns about their stability. Like ynamides, ynol ethers are relatively unhindered to approach by functional groups present in the same or different molecules because of their linear geometry, and they can potentially form up to four new bonds in a single transformation...
June 21, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27131308/efficiency-of-a-photoreactor-packed-with-immobilized-titanium-dioxide-nanoparticles-in-the-removal-of-acid-orange-7
#18
Behnaz Sheidaei, Mohammad A Behnajady
In this paper, the removal efficiency of Color Index Acid Orange 7 (AO7) as a model contaminant was investigated in a batch-recirculated photoreactor packed with immobilized titanium dioxide type P25 nanoparticles on glass beads. The effects of different operational parameters such as the initial concentration of AO7, the volume of solution, the volumetric flowrate, and the light source power in the photoreactor were investigated. The results indicate that the removal percent increased with the rise in volumetric flowrate and power of the light source, but decreased with the rise of the initial concentration of AO7 and the volume of solution...
May 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/27064419/a-chiral-electrophilic-selenium-catalyst-for-highly-enantioselective-oxidative-cyclization
#19
Yu Kawamata, Takuya Hashimoto, Keiji Maruoka
Chiral electrophilic selenium catalysts have been applied to catalytic asymmetric transformations of alkenes over the past two decades. However, highly enantioselective reactions with a broad substrate scope have not yet been developed. We report the first successful example of this reaction employing a catalyst based on a rigid indanol scaffold, which can be easily synthesized from a commercially available indanone. The reaction efficiently converts β,γ-unsaturated carboxylic acids into various enantioenriched γ-butenolides under mild conditions...
April 27, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27011195/enantioselective-determination-of-polycyclic-musks-in-river-and-wastewater-by-gc-ms-ms
#20
Injung Lee, Anantha-Iyengar Gopalan, Kwang-Pill Lee
The separation of chiral compounds is an interesting and challenging topic in analytical chemistry, especially in environmental fields. Enantioselective degradation or bioaccumulation has been observed for several chiral pollutants. Polycyclic musks are chiral and are widely used as fragrances in a variety of personal care products such as soaps, shampoos, cosmetics and perfumes. In this study, the gas chromatographic separation of chiral polycyclic musks, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclo-penta-γ-2-benzopyrane (HHCB), 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetra-hydronaphthalene (AHTN), 6-acetyl-1,1,2,3,3,5-hexamethylindane (AHDI), 5-acetyl-1,1,2,6-tetramethyl-3-iso-propylindane (ATII), and 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone (DPMI) was achieved on modified cyclodextrin stationary phase (heptakis (2,3-di-O-methyl-6-O-tert-butyl-dimethylsilyl-β-CD in DV-1701))...
March 22, 2016: International Journal of Environmental Research and Public Health
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