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Nigella sativa ( black cumin )

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https://www.readbyqxmd.com/read/29751576/thymoquinone-suppresses-irf-3-mediated-expression-of-type-i-interferons-via-suppression-of-tbk1
#1
Nur Aziz, Young-Jin Son, Jae Youl Cho
Interferon regulatory factor (IRF)-3 is known to have a critical role in viral and bacterial innate immune responses by regulating the production of type I interferon (IFN). Thymoquinone (TQ) is a compound derived from black cumin ( Nigella sativa L.) and is known to regulate immune responses by affecting transcription factors associated with inflammation, including nuclear factor-κB (NF-κB) and activator protein-1 (AP-1). However, the role of TQ in the IRF-3 signaling pathway has not been elucidated...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29656006/par-4-dependent-p53-up-regulation-plays-a-critical-role-in-thymoquinone-induced-cellular-senescence-in-human-malignant-glioma-cells
#2
Karthikeyan Subburayan, Faisal Thayyullathil, Siraj Pallichankandy, Anees Rahman, Sehamuddin Galadari
Thymoquinone (TQ), the predominant bioactive constituent present in black cumin (Nigella sativa), exerts tumor suppressive activity against a wide variety of cancer cells. Cellular senescence, characterized by stable and long term loss of proliferative capacity, acts as a potent tumor suppressive mechanism. Here, we provide evidence for the first time that TQ suppresses growth of glioma cells by potentially inducing the expression of prostate apoptosis response-4 (Par-4) tumor suppressor protein. In turn, TQ-induced Par-4 expression triggers cellular senescence, as evidenced by increasing cellular size, β-galactosidase staining, G1 phase arrest, and increased expression of senescence markers such as p53, p21, Rb, and decreased expression of lamin B1, cyclin E and cyclin depended kinase-2 (CDK-2)...
April 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29648463/protective-effect-of-thymoquinone-the-main-component-of-nigella-sativa-against-diazinon-cardio-toxicity-in-rats
#3
Gholam Hassan Danaei, Bahram Memar, Ramin Ataee, Mohammad Karami
Several studies have shown that oxidative stress and cell damage can occur at very early stages of diazinon (DZN) exposure. The present study was designed to determine the beneficial effect of thymoquinone (Thy), the main component of Nigella sativa (black seed or black cumin), against DZN cardio-toxicity in rats. In the present experimental study, 48 male Wistar rats were randomly divided into six groups: control (corn oil gavages), DZN gavages (20 mg/kg/day), Thy gavages (10 mg/kg/day) and Thy + DVN gavages (2...
April 12, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29606758/some-microbiological-physicochemical-and-ripening-properties-of-erzincan-tulum-cheese-produced-with-added-black-cumin-nigella-sativa-l
#4
Yusuf Çakır, Songül Çakmakçı
The effects of black cumin (BC) at 0, 1 or 2% in Erzincan Tulum cheese (Tulum cheese) on its microbiological, chemical and proteolysis properties during ripening were investigated. The addition of BC caused an increase in the dry matter, protein, ash, total nitrogen (TN), water-soluble nitrogen (WSN) (% of TN) (ripening index), 5% phosphotungstic acid soluble nitrogen (PTA-SN) (% of TN), and 12% trichloroacetic acid soluble nitrogen (TCA-SN) (% of TN) concentrations compared to BC-free (control) cheese. Additionally, the addition of BC caused a decrease in coliforms, yeasts & moulds, fat-in-dry matter (FDM), pH, and acidity...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29587770/powdered-black-cumin-seeds-strongly-improves-serum-lipids-atherogenic-index-of-plasma-and-modulates-anthropometric-features-in-patients-with-hashimoto-s-thyroiditis
#5
Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri
BACKGROUND: Hashimoto's thyroiditis is associated with serious alterations in serum lipids and glucose homeostasis. The aims of the current study were to evaluate the effect of powdered Nigella sativa on serum lipids, glucose homeostasis and anthropometric variables in patients with Hashimoto's thyroiditis. METHODS: Forty patients with Hashimoto's thyroiditis, aged between 22 and 50 years old, participated in the trial and were randomly allocated into two groups of intervention and control receiving powdered Nigella sativa or placebo daily for 8 weeks...
March 27, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29518971/dietary-plants-for-the-prevention-and-management-of-kidney-stones-preclinical-and-clinical-evidence-and-molecular-mechanisms
#6
REVIEW
Mina Cheraghi Nirumand, Marziyeh Hajialyani, Roja Rahimi, Mohammad Hosein Farzaei, Stéphane Zingue, Seyed Mohammad Nabavi, Anupam Bishayee
Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. Camellia sinensis (green tea), Rubus idaeus (raspberry), Rubia cordifolia (common madder), Petroselinum crispum (parsley), Punica granatum (pomegranate), Pistacia lentiscus (mastic), Solanum xanthocarpum (yellow-fruit nightshade), Urtica dioica (stinging nettle), Dolichos biflorus ( horse gram ), Ammi visnaga (khella), Nigella sativa (black-cumin), Hibiscus sabdariffa (roselle), and Origanum vulgare (oregano) have received considerable interest based on scientific evidence...
March 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29493013/carcass-characteristics-chemical-and-fatty-acid-composition-and-oxidative-stability-of-meat-from-broiler-chickens-fed-black-cumin-nigella-sativa-seeds
#7
P Kumar, A K Patra, G P Mandal, B C Debnath
A study was conducted to investigate the dietary supplementation of black cumin seeds (BCS) on carcass characteristics, chemical and fatty acid (FA) composition and antioxidant properties of thigh and breast meat of broiler chickens at 42 days of age. Three hundred sixty 1-day-old broiler chickens were allocated to five dietary treatment groups (each group containing eight replicate pens with each pen containing nine broiler chickens): basal diet (control; CON), CON + 0.05 g/kg of bacitracin methylene disalicylate (AB), CON + 5 g/kg of BCS (low dose of BCS), CON + 10 g/kg of BCS (medium dose of BCS) and CON + 20 g/kg of BCS (high dose of BCS)...
June 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29455727/enhancement-of-gut-permeation-of-amoxicillin-with-nigella-sativa-seed-extract-and-its-phytochemical-screening
#8
Babar Ali, Mohammad Ali, Saima Amin, Showkat R Mir
The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the gut wall. The methanolic extract of N. sativa improved intestinal permeability of amoxicillin in in-vitro experiments in a dose-dependent manner. Two new glycosides, decanyl nigelloic acid diglucoside [n-decanyl-3-aldehydic-4-methoxy-5-hydroxy benzoate-5-β-D-glucofuranosyl (2→1)-β-D-glucopyranosyl-(2→1)-β-D-glucopyranoside]] and nigelabdienoyl triglucoside [homo-labd-5, 9(11)-dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D-glucopyranoside], along with seven known fatty acid glycerides/esters, were isolated from the gut permeation enhancing extract...
February 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29433684/short-and-long-term-modulation-of-tissue-minerals-concentrations-following-oral-administration-of-black-cumin-nigella-sativa-l-seed-oil-to-laboratory-rats
#9
Irum Basheer, Irfan Zia Qureshi
BACKGROUND: Nigella sativa, or commonly called black cumin is a small herb of family Ranunculaceae is a well-known medicinal plant but its effects on tissue mineral concentrations of animal bodies is unknown. PURPOSE: To study the effect of oral administration of fixed oil of black cumin seeds on tissues mineral content using laboratory rats as experimental model. STUDY DESIGN: Experimental animals were exposed to two oral doses of seed oil (60 and 120 ml kg-1 body weight)...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29403626/a-review-of-effective-herbal-medicines-in-controlling-menopausal-symptoms
#10
REVIEW
Rahele Kargozar, Hoda Azizi, Roshanak Salari
Background: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. Objective: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29387368/the-influence-of-pulsed-electric-fields-and-microwave-pretreatments-on-some-selected-physicochemical-properties-of-oil-extracted-from-black-cumin-seed
#11
Hamid Bakhshabadi, HabibOllah Mirzaei, Alireza Ghodsvali, Seid Mahdi Jafari, Aman Mohammad Ziaiifar
Application of novel technologies such as microwave and pulsed electric fields (PEF) might increase the speed and efficiency of oil extraction. In the present research, PEF (3.25 kV/cm electric field intensity and 30 pulse number) and microwave (540 W for 180 s) pretreatments were used to study the process of oil extraction from black cumin ( Nigella sativa ) seeds. After applying the selected pretreatments, the oil of seeds was extracted with the use of a screw press and the extraction efficiency, refractive index, oil density, color index, oxidative stability, and chemical components of oil and protein of meal were evaluated...
January 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29318975/evaluation-of-the-antiproliferative-activity-of-some-nanoparticulate-essential-oils-formulated-in-microemulsion-on-selected-human-carcinoma-cell-lines
#12
Ahmed Abd-Rabou, Amr E Edris
BACKGROUND: Essential oils (EOs) are natural volatile plant extract that have different biological activities including antiproliferative potentials. OBJECTIVE: the current study aims at evaluating the antiproliferative activities of six EOs in their neat state compared to their nanoparticulate form after fabrication in microemulsion against some cancer cell lines. The EOs included marjoram (Origanum majorana), turmeric (Curcuma longa), sweet basil (Ocimum basillicum), clove buds (Syzygium aromaticum), geranium (plargonium graviolenis), and black cumin (Nigella sativa)...
January 10, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29223554/oral-administration-of-nigella-sativa-oil-and-thymoquinone-attenuates-long-term-cisplatin-treatment-induced-toxicity-and-oxidative-damage-in-rat-kidney
#13
Zeba Farooqui, Faaiza Shahid, Aijaz Ahmed Khan, Farah Khan
Cisplatin (CP) is an effective anti-cancer drug which causes remarkable toxicity to the kidney, particularly to proximal tubules, by generating reactive oxygen species. Nigella sativa (NS), commonly known as "black cumin" reduces the progression of various kidney disorders. Thymoquinone (TQ), the major bioactive constituent of NS seeds, has been credited for various pharmacological effects of NS. Since, a typical clinical CP dosing regimen involves CP administration in multiple cycles over a long time duration, hence the present study aimed to evaluate the renoprotective efficacy of NS oil and TQ against multiple dose CP treatment induced deleterious biochemical and histological alterations in rat kidney...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29200724/bioassay-guided-isolation-of-neuroprotective-fatty-acids-from-nigella-sativa-against-1-methyl-4-phenylpyridinium-induced-neurotoxicity
#14
Leila Hosseinzadeh, Hoda Monaghash, Farahnaz Ahmadi, Nastaran Ghiasvand, Yalda Shokoohinia
Objective: Parkinson's disease, a slowly progressive neurological disease, is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine. The main aspects of researches are the protection of normal neurons against degeneration. Fatty acids (FAs), the key structural elements of dietary lipids, are carboxylic straight chains and notable parameters in nutritional and industrial usefulness of a plant. Materials and Methods: Black cumin, a popular anti-inflammatory and antioxidant food seasoning, contains nonpolar constituents such as FAs which were extracted using hexane...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29172688/effect-of-nanoparticle-treatment-on-expression-of-a-key-gene-involved-in-thymoquinone-biosynthetic-pathway-in-nigella-sativa-l
#15
Mir Mohammad Hassan Kahila, Amin Mahdi Najy, Mahdi Rahaie, Mohammad Mir-Derikvand
Thymoquinone is the most important secondary metabolite in black Cumin, which has several pharmaceutical applications. In this study, effect of TiO2 and SiO2 nanoparticles as new elicitors, on expression of Geranyl diphosphate synthase gene (GPPS gene), as a key gene involved in thymoquione biosynthesis pathway was investigated in two Iranian accessions. Plants were treatment in the early flowering stage and after 24 h of 50 and 100 mg/L of each nanoparticle, separately. After RNA extraction, GPPS gene expression was analysed by qRT-PCR method...
November 27, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28988684/a-potent-nutraceutical-combination-of-cinnamomum-cassia-nigella-sativa-for-type-1-diabetes-mellitus
#16
Ginpreet Kaur, Mihir Invally, Mohammed Kamil Khan, Priyanka Jadhav
BACKGROUND: Nigella sativa (black cumin) and Cinnamomum cassia (Cinnamon) are an integral part of the Indian diet, and have also been sourced in the ayurveda, the traditional Indian system of medicine, for their medicinal properties. Both the herbs individually have been successfully evaluated for their preliminary antidiabetic potential. AIM: Herein, we dived deeper into antidiabetic properties of these herbs, by investigating the combinatorial effect of both herbs, on parameters of diabetes and further, as an adjunct to metformin therapy, for assessing the pharmacodynamics of herb-drug interaction in diabetes mellitus...
October 5, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28983249/therapeutic-potential-and-pharmaceutical-development-of-thymoquinone-a-multitargeted-molecule-of-natural-origin
#17
REVIEW
Sameer N Goyal, Chaitali P Prajapati, Prashant R Gore, Chandragouda R Patil, Umesh B Mahajan, Charu Sharma, Sandhya P Talla, Shreesh K Ojha
Thymoquinone, a monoterpene molecule is chemically known as 2-methyl-5-isopropyl-1, 4-benzoquinone. It is abundantly present in seeds of Nigella sativa L. that is popularly known as black cumin or black seed and belongs to the family Ranunculaceae. A large number of studies have revealed that thymoquinone is the major active constituent in N. sativa oil this constituent is responsible for the majority of the pharmacological properties. The beneficial organoprotective activities of thymoquinone in experimental animal models of different human diseases are attributed to the potent anti-oxidant and anti-inflammatory properties...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28938193/protective-effect-of-thymoquinone-against-diazinon-induced-hematotoxicity-genotoxicity-and-immunotoxicity-in-rats
#18
Gholam Hassan Danaei, Mohammad Karami
Several studies have shown that oxidative stress and cell damage can occur in the very early stages of diazinon (DZN) exposure. The present study was designed to determine the beneficial effect of thymoquinone (Thy), the main component of Nigella sativa (black seed or black cumin) against DZN immunotoxicity, hematotoxicity and genotoxicity in rats. In the present experimental study, 48 male Wistar rats were randomly divided into six groups, (eight per group) as follows: control (receiving corn oil as the DZN solvent), DZN (20mg/kg), Thy (10mg/kg), Thy (2...
September 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28892789/thymoquinone-rich-fraction-nanoemulsion-tqrfne-decreases-a%C3%AE-40-and-a%C3%AE-42-levels-by-modulating-app-processing-up-regulating-ide-and-lrp1-and-down-regulating-bace1-and-rage-in-response-to-high-fat-cholesterol-diet-induced-rats
#19
Norsharina Ismail, Maznah Ismail, Nur Hanisah Azmi, Muhammad Firdaus Abu Bakar, Zhang Yida, Maizaton Atmadini Abdullah, Hamidon Basri
Though the causes of Alzheimer's disease (AD) are yet to be understood, much evidence has suggested that excessive amyloid-β (Aβ) accumulation due to abnormal amyloid-β precursor protein (APP) processing and Aβ metabolism are crucial processes towards AD pathogenesis. Hence, approaches aiming at APP processing and Aβ metabolism are currently being actively pursued for the management of AD. Studies suggest that high cholesterol and a high fat diet have harmful effects on cognitive function and may instigate the commencement of AD pathogenesis...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28791082/protective-effect-of-nigella-sativa-oil-on-acoustic-trauma-induced-hearing-loss-in-rats
#20
Belde Culhaoglu, Selim S Erbek, Seyra Erbek, Evren Hizal
Acoustic trauma is a common reason for hearing loss. Different agents are used to prevent the harmful effect of acoustic trauma on hearing. The aim of this study was to evaluate the potential preventive effect of Nigella sativa (black cumin) oil in acoustic trauma. Our experimental study was conducted with 20 Sprague Downey female rats (mean age, 12 months; mean weight 250 g). All of the procedures were held under general anesthesia. Following otoscopic examinations, baseline-hearing thresholds were obtained using auditory brainstem responses (ABR)...
July 18, 2017: Audiology Research
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