keyword
https://read.qxmd.com/read/38542995/variation-in-the-composition-and-quality-of-nigella-sativa-l-seed-oils-the-underestimated-impact-on-possible-health-promoting-properties
#1
JOURNAL ARTICLE
Grzegorz Dąbrowski, Sylwester Czaplicki, Iwona Konopka
Nigella sativa L. (black cumin) is one of the most investigated medicinal plants in recent years. Volatile compounds like thymoquinone and unsaponifiable lipid compounds are crucial functional components of this oil. Unfortunately, the composition of oils and their quality indicators are ambiguous both in terms of identified compounds and value ranges. Thirteen oils were extracted with hexane from black cumin seeds grown in India, Syria, Egypt, and Poland and analyzed for their fatty acid composition, unsaponifiable compound content and volatile compounds...
March 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38534556/biohydrogen-production-from-waste-black-cumin-nigella-sativa-extract-liquid
#2
JOURNAL ARTICLE
Nesrin Dursun, Hakki Gülşen
Hydrogen creates water during combustion. Therefore, it is expected to be the most promising environmentally friendly energy alternative in the coming years. This study used extract liquid obtained from the waste nigella sativa generated by the black cumin oil industry. The performance of biological hydrogen manufacturing via dark fermentation was investigated in the fluidized bed reactor (FBR) and completely stirred tank reactor (CSTR) under the operation conditions of pH 5.0, 4.0, and 6.0 and a hydraulic retention time (HRT) of 36 and 24 h...
March 16, 2024: Bioengineering
https://read.qxmd.com/read/38510007/immune-stimulatory-effect-of-nigella-sativa-in-healthy-animal-models-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Abdulsamad Alsalahi, Nian N N Maarof, Mohammed A Alshawsh, Musheer A Aljaberi, Mousa A Qasem, Abdulaleem Mahuob, Nassrin A Badroon, Ebthag A M Mussa, Rukman A Hamat, Atiyah M Abdallah
The immune-modulatory effects of black seeds ( Nigella sativa seeds, NSS) are well documented, but the overall in vivo impact of this important natural medicinal product on immune system function has yet to be established. Here we systematically reviewed and meta-analyzed the effects of NSS on humoral [serum titers of immunoglobulins including IgG, IgM, anti-Newcastle virus disease (anti-NDV), and sheep red blood cell antigen (anti-SRBC)] and cellular immunity [total white blood cell (WBC) count and percentages of monocytes, lymphocytes, basophils, neutrophils, and eosinophils] in healthy animals...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38454971/phytocompounds-of-nigella-sativa-seeds-extract-and-their-neuroprotective-potential-via-egr1-receptor-inhibition-a-molecular-docking-study
#4
JOURNAL ARTICLE
Kulsum Kulsum, Syahrul Syahrul, Kartini Hasbalah, Ummu Balqis
Bioactivity of Nigella sativa seed extract has the potential as a neuro-protector, offering its promising utility in the clinical setting for brain injury management. This study aimed to identify the phytocompounds contained in the extract of N. sativa seeds and further screen their respective neuronal anti-inflammatory activities in silico. The extract of N. sativa seeds was prepared through successive maceration using non-polar to polar solvents (n-hexane and ethanol, respectively). The phytocompounds in the ethanolic extract were initially identified through qualitative analysis and further analyzed with gas chromatography-mass spectrometry (GC-MS)...
August 2023: Narra J
https://read.qxmd.com/read/38414487/corrigendum-exploring-the-short-term-influence-of-a-proprietary-oil-extract-of-black-cumin-nigella-sativa-on-non-restorative-sleep-a-randomized-double-blinded-placebo-controlled-actigraphy-study
#5
M E Mohan, Mohind C Mohan, Prathibha Prabhakaran, S Syam Das, I M Krishnakumar, P S Baby Chakrapani
[This corrects the article DOI: 10.3389/fnut.2023.1200118.].
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38409693/the-emergence-of-n-sativa-l-as-a-green-antifungal-agent
#6
JOURNAL ARTICLE
Raghvendra Pandey, Brijesh Pandey, Atul Bhargava
BACKGROUND: Nigella sativa L. has been widely used in the Unani, Ayurveda, Chinese, and Arabic medicine systems and has a long history of medicinal and folk uses. Several phytoconstituents of the plant are reported to have excellent therapeutic properties. In-vitro and in-vivo studies have revealed that seed oil and thymoquinone have excellent inhibitory efficacy on a wide range of both pathogenic and non-pathogenic fungi. OBJECTIVE: The present review aims to undertake a comprehensive and systematic evaluation of the antifungal effects of different phytochemical constituents of black cumin...
February 23, 2024: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/38407314/designing-novel-industrial-and-functional-foods-using-the-bioactive-compounds-from-nigella-sativa-l-black-cumin-biochemical-and-biological-prospects-toward-health-implications
#7
REVIEW
Muhammad H Alu'datt, Taha Rababah, Doa'a G F Al-U'datt, Sana Gammoh, Sharifa Alkandari, Ahmed Allafi, Mohammad Alrosan, Stan Kubow, Haneen K Al-Rashdan
Nigella sativa is one of the nutraceuticals that has gained popularity and studied extensively in recent decades as it is considered a safe medicinal plant for use as a dietary supplement. N. sativa contains a wide variety of bioactive substances, which include polyphenols, volatile oils (thymoquinone and p-cymene), proteins, and peptides. The biological attributes of N. sativa include antioxidant, antimicrobial, antifungal, anti-inflammatory, anticancer, antidiabetic, antihypertensive, hypolipidemic, and antioxidant activities, which have potential applications for the prevention of a variety of chronic diseases...
February 26, 2024: Journal of Food Science
https://read.qxmd.com/read/38398007/the-use-of-nigella-sativa-in-cardiometabolic-diseases
#8
REVIEW
Giuseppe Derosa, Angela D'Angelo, Pamela Maffioli, Laura Cucinella, Rossella Elena Nappi
Nigella sativa L. is an herb that is commonly used in cooking and in traditional medicine, particularly in Arab countries, the Indian subcontinent, and some areas of eastern Europe. Nigella sativa is also called "black cumin" or "black seeds", as the seeds are the most-used part of the plant. They contain the main bioactive component thymoquinone (TQ), which is responsible for the pleiotropic pharmacological properties of the seeds, including anti-oxidant, anti-inflammatory, anti-hypertensive, anti-hepatotoxic, hypoglycemic, and lipid-lowering properties...
February 9, 2024: Biomedicines
https://read.qxmd.com/read/38397532/physicochemical-rheological-and-sensory-evaluation-of-herbal-bread-containing-turmeric-ginger-and-black-cumin-powder
#9
JOURNAL ARTICLE
Muhammad Suffyan Saddique, Muhammad Tauseef Sultan, Shahzad Zafar Iqbal, Christine Bosch, Saeed Akhtar, Hassan Raza, Naima Tariq, Waqas Ahmed
The diversity in the global food market is expanding as thousands of new products enter the business every year, among which nutraceutical and functional foods hold important positions. The present research work aimed at the nutritional evaluation of three medicinal herbs, i.e., turmeric ( Curcuma longa L.), ginger ( Zingiber officinale ), and black cumin ( Nigella sativa ). A bread formulation was enriched with the individual/combined supplementation (1-3%) of these herbs. Later, the bread was analyzed for nutritional, rheological, textural, and sensorial characteristics...
February 12, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38338478/enhancement-of-female-rat-fertility-via-ethanolic-extract-from-nigella-sativa-l-black-cumin-seeds-assessed-via-hplc-esi-ms-ms-and-molecular-docking
#10
JOURNAL ARTICLE
Ahmed M Nagy, Mohamed F Abdelhameed, Asmaa S Abd Elkarim, Tushar C Sarker, Ahmed M Abd-ElGawad, Abdelsamed I Elshamy, Abdelmohsen M Hammam
The characteristic chemical composition of Nigella seeds is directly linked to their beneficial properties. This study aimed to investigate the phytochemical composition of Nigella sativa seeds using a 100% ethanolic extract using HPLC-ESI-MS/MS. Additionally, it explored the potential biological effects of the extract on female rat reproduction. Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Estrogen (E2), and Progesterone (P4) hormone levels were also assessed, along with the morphological and histological effects of the extract on ovarian, oviductal, and uterine tissues...
February 5, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38326995/testing-the-detoxification-power-of-black-cumin-oil-nigella-sativa-over-cypermethrin-insecticide-effects-in-rainbow-trout-oncorhynchus-mykiss-at-multiple-scales
#11
JOURNAL ARTICLE
Veysel Karani Gültekin, Muhammed Atamanalp, Arzu Ucar, Gonca Alak, Veysel Parlak
This study investigated the curative effect of black cumin oil ( Nigella sativa , NS), which is a phytotherapeutic agent against to cypermethrin (CYP), which is known to have adverse effects on rainbow trout ( Oncorhynchus mykiss )'s behavioral changes, oxidative stress-mediated neurotoxicity, hematotoxicity and hepatotoxicity parameters.At the end of the trial period; (i) evaluation of critical swimming speed (Ucrit ) (ii) hematology indices [white blood cell (WBC), red blood cell (RBC), hemoglobin (Hgb), hematocrit (Hct), mean cell volume (MCV), mean cell hemoglobin) (MCH), mean cell hemoglobin concentration (MCHC)] (iii) Elucidation of the mechanism of functional damage in brain tissue of O...
February 7, 2024: Drug and Chemical Toxicology
https://read.qxmd.com/read/38253839/silicon-and-titanium-nanoparticles-modulated-drought-and-chromium-toxicity-by-adjusting-physio-biochemical-attributes-and-fatty-acid-profiles-of-black-cumin-nigella-sativa-l
#12
JOURNAL ARTICLE
Zhen Chen, Nada Othman Kattab
Drought and chromium (Cr) stress are the main environmental issues affecting plant performance. Although the positive effects of silicon dioxide (SiO2 ) and titanium dioxide (TiO2 ) nanoparticles (NPs) are used as a promising strategy to control abiotic stresses; their synergic effects on controlling drought and Cr toxicity are unknown. This study aimed to investigate the effects of foliar applications of SiO2 (200 mg L-1 ) and TiO2 (60 mg L-1 ) NPs on growth, chlorophyll (Chl) content, lipid peroxidation, antioxidant enzyme, and fatty acid profile of black cumin (Nigella sativa L...
January 23, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38197611/an-investigation-into-the-usage-of-black-cumin-derivatives-against-cancer-and-covid-19-as-the-nature-medicine
#13
JOURNAL ARTICLE
Faik Gökalp
Black cumin has been used as a spice and food preservative for years. Thymol, thymoquinone, thymohydroquinone and dihydrothymoquinone are the most important natural agents in black cumin. In order to determine the most active compound in black cumin the theoretical calculations have been carried out in different phases by using the density functional theory (DFT). The inhibition effect of black cumin derivatives on Histone deacetylase 2 (HDAC2) has been determined and supported the experimental studies without losing time and matter...
January 10, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38074008/assessment-of-antimicrobial-activity-and-cytotoxic-effect-of-nigella-sativa-syzygium-aromaticum-and-allium-cepa-formulation-for-use-as-antimicrobial-gel-or-mouthwash
#14
JOURNAL ARTICLE
N Fazulunnisa Begum, Gheena S, Pratibha Ramani, Rajeshkumar S, Karthikeyan Ramalingam, Abilasha Ramasubramanian
BACKGROUND: Black cumin/ Nigella sativa  is traditionally used for its wide range of medicinal effects. Clove/ Syzygium aromaticum  is well known as a natural antibiotic with antiviral, antibacterial, and antifungal properties, and onion/ Allium cepa  for its antibacterial properties. The combination of these extracts can effectively have many therapeutic applications. AIM: The aim of the present study is to prepare the formulation of  N. sativa, S...
November 2023: Curēus
https://read.qxmd.com/read/38005726/potential-pharmacological-applications-of-nigella-seeds-with-a-focus-on-nigella-sativa-and-its-constituents-against-chronic-inflammatory-diseases-progress-and-future-opportunities
#15
REVIEW
Shadma Wahab, Abdulrhman Alsayari
The leading cause of death worldwide has been identified as chronic illnesses, according to the World Health Organization (WHO). Chronic inflammatory conditions such as asthma, cancer, diabetes, heart disease, and obesity account for three out of every five deaths. Although many people benefit from using nonsteroidal anti-inflammatory medicines (NSAIDs) for pain and inflammation relief, there are significant adverse effects to using these medications. Medicinal plants possess anti-inflammatory properties with minimal or no side effects...
November 11, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38004077/in-vitro-assessment-of-anti-adipogenic-and-anti-inflammatory-properties-of-black-cumin-nigella-sativa-l-seeds-extract-on-3t3-l1-adipocytes-and-raw264-7-macrophages
#16
JOURNAL ARTICLE
Khawaja Muhammad Imran Bashir, Jong-Kyu Kim, Yoon-Seok Chun, Jae-Suk Choi, Sae-Kwang Ku
Background and Objectives : This study evaluated the in vitro anti-adipogenic and anti-inflammatory properties of black cumin ( Nigella sativa L.) seed extract (BCS extract) as a potential candidate for developing herbal formulations targeting metabolic disorders. Materials and Methods: We evaluated the BCS extract by assessing its 2,2-diphenyl-1-picrohydrazyl (DPPH) radical scavenging activity, levels of prostaglandin E2 (PGE2 ) and nitric oxide (NO), and mRNA expression levels of key pro-inflammatory mediators...
November 17, 2023: Medicina
https://read.qxmd.com/read/37970392/the-effects-of-superheated-steam-roasting-on-proximate-analysis-antioxidant-activity-and-oil-quality-of-black-seed-nigella-sativa
#17
JOURNAL ARTICLE
K V Harivaindaran, Nguyễn Hữu Tiến, Toàn Nguyễn Song Đinh, Hayati Samsudin, Fazilah Ariffin, Abdorreza Mohammadi Nafchi
Nigella sativa , commonly known as the black seed, is a culinary spice therapeutic against many ailments. Common preparation practice of roasting or heating the seeds often deteriorates bioactive compounds, which can be remedied with superheated steam (SHS). With roasting temperatures of 150, 200, and 250°C and roasting times of 10, 15, and 20 min, convection and SHS roasting media were tested, and their effects on proximate analysis, antioxidant assays, and oil quality were evaluated. For proximate content, moisture significantly decreased from 9...
November 2023: Food Science & Nutrition
https://read.qxmd.com/read/37957516/topical-nigella-sativa-l-product-a-new-candidate-for-the-management-of-diabetic-peripheral-neuropathy
#18
RANDOMIZED CONTROLLED TRIAL
Seyed-Ali Khodaie, Haniyeh Nikkhah, Nasim Namiranian, Marzie Abotorabi, Maryam Askari, Saeed Hosein Khalilzadeh, Amidoddin Khatibi Aghda, Mohammad Kamalinejad
BACKGROUND: Diabetic neuropathy is one of the most common complications of diabetes. The synthetic drugs available in the market have side effects and limitations for diabetic patients, the vast majority of whom are in the upper age group. In this regard, based on Persian medicinal sources, Nigella sativa (N. sativa) has proved to have beneficial effects on neuropathic pain and neurological disorders. In this study, the effect of N. sativa is investigated topically in patients with diabetic neuropathy...
February 2024: Inflammopharmacology
https://read.qxmd.com/read/37885111/an-overview-of-conventional-and-black-cumin-seeds-nigella-sativa-therapy-in-the-management-of-nipah-viral-infection
#19
JOURNAL ARTICLE
Naina Mohamed Pakkir Maideen, Rajkapoor Balasubramaniam, Mohamed Harsath Jahir Hussain, Rupeshkumar Mani, Thirumal Margesan, Vasanth Kumar Solaimalai
The recent outbreaks of Nipah viral infection were associated with severe respiratory illness, lethal encephalitis, and an extremely high mortality rate. As there are no approved antiviral medications, patients with NiV infections are currently treated with repurposed or investigational antivirals and supportive care. This review examines the potential health benefits of N. sativa in the treatment of NiV infection. To identify relevant studies, the literature was searched in online databases like Medline/PubMed, Google Scholar, Science Direct, and reference lists...
October 25, 2023: Infectious Disorders Drug Targets
https://read.qxmd.com/read/37844615/effect-of-cold-pressed-nigella-sativa-seed-meal-on-dough-quality-and-nutritional-value-of-bread
#20
JOURNAL ARTICLE
Yavuz Yüksel, Mustafa Kiralan, Mohamed Fawzy Ramadan
This study investigated the application of black cumin meal (BCM) obtained from cold-pressing Nigella sativa seeds in bread baking. The effect of BCM on bread rheological traits and its nutritional value were investigated. Zeleny sedimentation, falling number, Farinograph, and Extensograph values in flour mixed with BCM (2.5%, 5%, 7.5%, and 10%) were evaluated. In addition, mineral content, protein, fat, thymoquinone, and crude cellulose contents in bread were investigated. Zeleny sedimentation and falling number values decreased with the increase in BCM in the flour samples...
October 16, 2023: Food Science and Technology International
keyword
keyword
76005
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.