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Nigella sativa ( black cumin )

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https://www.readbyqxmd.com/read/27904549/effects-of-nigella-sativa-supplementation-on-blood-parameters-and-anthropometric-indices-in-adults-a-systematic-review-on-clinical-trials
#1
REVIEW
Alireza Mohtashami, Mohammad Hasan Entezari
BACKGROUND: Nigella sativa (N. sativa) has been used in traditional medicine and several studies have been performed in the last decades to reveal the effects of it on different medical disorders such as diabetes, dyslipidemia, hypertension, and obesity. We evaluated the effects of N. sativa supplementation on lipid profiles, glycemic control, blood pressure (BP), and some anthropometric indices in humans. MATERIALS AND METHODS: A search on published studies was done by using databases including PubMed, Google Scholar, Thomas Reuters Web of Science, and Cochrane...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27752803/nigella-sativa-oil-reduces-extrapyramidal-symptoms-eps-like-behavior-in-haloperidol-treated-rats
#2
Tafheem Malik, Sheema Hasan, Shahid Pervez, Tasneem Fatima, Darakhshan Jabeen Haleem
The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls...
December 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27649635/recent-advances-on-the-anti-cancer-properties-of-nigella-sativa-a-widely-used-food-additive
#3
Amin F Majdalawieh, Muneera W Fayyad
The use of naturally-occurring agents to regulate tumorigenesis is on the rise. Several herbal extracts, pure plant-derived active constituents, and food additives have been reported to possess potent anti-cancer properties and cancer-ameliorating effects. The wide-range anti-cancer effects of Nigella sativa, also known as black seed or black cumin, have been extensively studied using different in vitro and in vivo models. Here, we provide a comprehensive, analytical review of the reported anti-cancer properties of N...
July 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27579151/nigella-sativa-relieves-the-altered-insulin-receptor-signaling-in-streptozotocin-induced-diabetic-rats-fed-with-a-high-fat-diet
#4
Mahmoud Balbaa, Marwa El-Zeftawy, Doaa Ghareeb, Nabil Taha, Abdel Wahab Mandour
The black cumin (Nigella sativa) "NS" or the black seeds have many pharmacological activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic properties. In this work, streptozotocin-induced diabetic rats fed with a high-fat diet were treated daily with NS oil (NSO) in order to study the effect on the blood glucose, lipid profile, oxidative stress parameters, and the gene expression of some insulin receptor-induced signaling molecules. This treatment was combined also with some drugs (metformin and glimepiride) and the insulin receptor inhibitor I-OMe-AG538...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27553624/nigella-sativa-black-cumin-seed-as-a-biological-detoxifier-in-diet-contaminated-with-aflatoxin-b1
#5
A A Rasouli-Hiq, F Bagherzadeh-Kasmani, M Mehri, M A Karimi-Torshizi
Aflatoxin B1 (AFB1 ) is a common feed contaminant that adversely affects bird performance and product quality. A total of 600 7-day-old quail chicks were randomly allotted to eight experimental groups in a completely randomized design with five replicate pens and 15 quails per pen. Experimental treatments including two levels of AFB1 (0 and 2.5 mg/kg) and 4 levels of Nigella sativa (NS) (0, 0.5, 1.0 and 1.5% of diet) were offered from 7 to 35 days of age to quail chicks. Although feeding of AFB1 impaired gain (G) and feed conversion ratio, dietary NS increased G (p < 0...
August 24, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27529277/spices-for-prevention-and-treatment-of-cancers
#6
REVIEW
Jie Zheng, Yue Zhou, Ya Li, Dong-Ping Xu, Sha Li, Hua-Bin Li
Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin...
August 12, 2016: Nutrients
https://www.readbyqxmd.com/read/27364039/preclinical-and-clinical-effects-of-nigella-sativa-and-its-constituent-thymoquinone-a-review
#7
REVIEW
Zahra Gholamnezhad, Shahrzad Havakhah, Mohammad Hossein Boskabady
ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa (N. sativa) L. (Ranunculaceae), well known as black cumin, has been used as a herbal medicine that has a rich historical background. It has been traditionally and clinically used in the treatment of several diseases. Many reviews have investigated this valuable plant, but none of them focused on its clinical effects. Therefore, the aim of the present review is to provide a comprehensive report of clinical studies on N. sativa and some of its constituents...
August 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27298589/panacea-seed-nigella-a-review-focusing-on-regenerative-effects-for-gastric-ailments
#8
Shahida A Khan, Aziz M Khan, Sajjad Karim, Mohammad Amjad Kamal, Ghazi A Damanhouri, Zeenat Mirza
Nigella sativa (NS) or black cumin is a dark, thin, and crescent-shaped, seeded shrub belonging to the Ranunculaceae family commonly growing on Mediterranean coasts in Saudi Arabia, northern Africa and Asia. They have amazing curative and therapeutic features that make them one of the most popular, safe, non-detrimental, and cytoprotective medicinal plant that can be used for prevention and treatment of many complicated diseases. Originally, N. sativa was used to treat migraines and allergy, and researches have shown its effectiveness in destroying cancer cells as well...
July 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27247917/renal-injury-nephrolithiasis-and-nigella-sativa-a-mini-review
#9
REVIEW
Parichehr Hayatdavoudi, Abolfazl Khajavi Rad, Ziba Rajaei, Mousa Al-Reza Hadjzadeh
OBJECTIVE: The incidence and prevalence of kidney stone is increasing worldwide. After the first recurrence the risk of subsequent relapses is higher and the time period between relapses is shortened. Urinary stones can be severely painful and make a huge economic burden. The stone disease may increase the vulnerability of patients to other diseases such as renal failure. Medicinal herbs are rich sources of antioxidants which are increasingly consumed globally for their safety, efficacy and low price...
January 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/27068721/chemical-composition-of-nigella-sativa-linn-part-2-recent-advances
#10
M Akram Khan, M Afzal
The black cumin or Nigella sativa L. seeds have many acclaimed medicinal properties such as bronchodilatory, hypotensive, antibacterial, antifungal, analgesic, anti-inflammatory and immunopotentiating. This review article is an update on the previous article published on Nigella sativa L. in this journal in 1999. It covers the medicinal properties and chemical syntheses of the alkaloids isolated from the seeds of the herb.
June 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27013802/in-silico-analysis-for-predicting-fatty-acids-of-black-cumin-oil-as-inhibitors-of-p-glycoprotein
#11
Babar Ali, Qazi Mohd Sajid Jamal, Showkat R Mir, Saiba Shams, Naser A Al-Wabel, Mohammad A Kamal
BACKGROUND: Black cumin oil is obtained from the seeds of Nigella sativa L. which belongs to family Ranunculaceae. The seed oil has been reported to possess antitumor, antioxidant, antibacterial, anti-inflammatory, hypoglycemic, central nervous system depressant, antioxidant, and immunostimulatory activities. These bioactivities have been attributed to the fixed oil, volatile oil, or their components. Seed oil consisted of 15 saturated fatty acids (17%) and 17 unsaturated fatty acids (82...
October 2015: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/26988509/microencapsulation-of-nigella-sativa-oleoresin-by-spray-drying-for-food-and-nutraceutical-applications
#12
Amr E Edris, Danuta Kalemba, Janusz Adamiec, Marcin Piątkowski
Oleoresin of Nigella sativa L. (Black cumin) was obtained from the seeds using hexane extraction at room temperature. The oleoresin was emulsified in an aqueous solution containing gum Arabic/maltodextrin (1:1 w/w) and then encapsulated in powder form by spray drying. The characteristics of the obtained powder including moisture content, bulk density, wettability, morphology, encapsulation efficiency were evaluated. The effect of the spray drying on the chemical composition of the volatile oil fraction of N...
August 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26774451/thymoquinone-strongly-inhibits-fmlf-induced-neutrophil-functions-and-exhibits-anti-inflammatory-properties-in-vivo
#13
Kaouthar Boudiaf, Margarita Hurtado-Nedelec, Sahra Amel Belambri, Jean-Claude Marie, Yacine Derradji, Mustapha Benboubetra, Jamel El-Benna, Pham My-Chan Dang
Polymorphonuclear neutrophils are key players in host defense against pathogens through the robust production of superoxide anion by the NADPH oxidase and the release of antibacterial proteins from granules. However, inappropriate release of these agents in the extracellular environment induces severe tissue injury, thereby contributing to the physiopathology of acute and chronic inflammatory disorders. Many studies have been carried out to identify molecules capable of inhibiting phagocyte functions, in particular superoxide anion production, for therapeutic purposes...
March 15, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/26680543/effects-of-nigella-sativa-l-seed-oil-on-intima-media-thickness-and-bax-and-caspase-3-expression-in-diabetic-rat-aorta
#14
Gökhan Cüce, Mehmet Enes Sözen, Seda Çetinkaya, Halime Tuba Canbaz, Hatice Seflek, Serpil Kalkan
OBJECTIVE: Hyperglycaemia is an important risk factor for the development and progression of the macrovascular and microvascular complications that occur in diabetes. The expression of apoptotic markers in the aortic medial layer of diabetic rats and the effects of N. sativa L. seed oil on the expression of these markers were investigated in this study. METHODS: Four-month-old adult female Wistar rats (n=21) were divided into 3 groups: Group 1, control; Group 2, diabetes and Group 3, diabetes+N...
July 14, 2015: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/26366755/black-cumin-nigella-sativa-and-its-active-constituent-thymoquinone-an-overview-on-the-analgesic-and-anti-inflammatory-effects
#15
REVIEW
Bahareh Amin, Hossein Hosseinzadeh
For many centuries, seeds of Nigella sativa (black cumin), a dicotyledon of the Ranunculaceae family, have been used as a seasoning spice and food additive in the Middle East and Mediterranean areas. Traditionally, the plant is used for asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, eczema, fever, dizziness, and gastrointestinal disturbances. The literature regarding the biological activities of seeds of this plant is extensive, citing bronchodilative, anti-inflammatory, antinociceptive, antibacterial, hypotensive, hypolipidemic, cytotoxic, antidiabetic, and hepatoprotective effects...
January 2016: Planta Medica
https://www.readbyqxmd.com/read/26352334/study-on-the-effect-of-black-cumin-nigella-sativa-linn-on-experimental-renal-ischemia-reperfusion-injury-in-rats
#16
Ghafour Mousavi
PURPOSE: To evaluate the effect of Black cumin (Nigella sativa Linn.) pre-treatment on renal ischemia/reperfusion (I/R) induced injury in the rats. METHODS: A total of 40 male Wistar rats were randomly allocated into five equal groups including Sham, I/R model and three I/R+ Black cumin (0.5, 1 and 2%)-treated groups. I/R groups' kidneys were subjected to 60 min of global ischemia at 37°C followed by 24 h of reperfusion. At the end of reperfusion period, the rats were euthanized...
August 2015: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/26304932/enhancement-of-bioavailability-and-pharmacodynamic-effects-of-thymoquinone-via-nanostructured-lipid-carrier-nlc-formulation
#17
Mohammed Elmowafy, Ahmed Samy, Mohamed A Raslan, Ayman Salama, Ragab A Said, Abdelaziz E Abdelaziz, Wafaa El-Eraky, Sally El Awdan, Tapani Viitala
Thymoquinone (TQ), obtained from black cumin (Nigella sativa), is a natural product with anti-oxidant, anti-inflammatory, and hepatoprotective effects but unfortunately with poor bioavailability. Aiming to improve its poor oral bioavailability, TQ-loaded nanostructured lipid carriers (NLCs) were prepared by high-speed homogenization followed by ultrasonication and evaluated in vitro. Bioavailability and pharmacodynamic studies were also performed. The resultant NLCs showed poor physical homogeneity in Compritol 888 ATO Pluronic F127 system which consequently produced larger particle size and polydispersity index, smaller zeta potential values, and lower short-term (30 days) physical stability than other systems...
June 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/26298318/anti-inflammatory-effects-of-thymoquinone-in-activated-bv-2-microglial-cells
#18
Equar Taka, Elizabeth A Mazzio, Carl B Goodman, Natalie Redmon, Hernan Flores-Rozas, Renee Reams, Selina Darling-Reed, Karam F A Soliman
Thymoquinone (TQ), the main pharmacological active ingredient within the black cumin seed (Nigella sativa) is believed to be responsible for the therapeutic effects on chronic inflammatory conditions such as arthritis, asthma and neurodegeneration. In this study, we evaluated the potential anti-inflammatory role of TQ in lipopolysaccharide (LPS)-stimulated BV-2 murine microglia cells. The results obtained indicate that TQ was effective in reducing NO2(-) with an IC50 of 5.04μM, relative to selective iNOS inhibitor LNIL-l-N6-(1-iminoethyl)lysine (IC50 4...
September 15, 2015: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/26265495/protective-efficacy-of-nigella-sativa-seeds-and-oil-against-columnaris-disease-in-fishes
#19
H H Mohammed, C R Arias
Columnaris disease, caused by the bacterium Flavobacterium columnare, is currently the most frequently reported bacterial disease affecting farm-raised channel catfish in the USA. Common treatments against the disease include the use of medicated feed that has led to emergent antibiotic resistant strains of F. columnare. Nigella sativa (Black cumin) is a medicinal herb commonly used by many cultures as a natural remedy for numerous disorders. Recently, we have discovered the antibacterial activity of N. sativa and its oil extract against F...
June 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/26122733/synthesis-characterization-and-biocompatibility-of-silver-nanoparticles-synthesized-from-nigella-sativa-leaf-extract-in-comparison-with-chemical-silver-nanoparticles
#20
COMPARATIVE STUDY
Rayhaneh Amooaghaie, Mohammad Reza Saeri, Morteza Azizi
Despite the development potential in the field of nanotechnology, there is a concern about possible effects of nanoparticles on the environment and human health. In this study, silver nanoparticles (AgNPs) were synthesized by 'green' and 'chemical' methods. In the wet-chemistry method, sodium borohydrate, sodium citrate and silver nitrate were used as raw materials. Leaf extract of Nigella sativa was used as reducing as well as capping agent to reduce silver nitrate in the green synthesis method. In addition, toxic responses of both synthesized AgNPs were monitored on bone-building stem cells of mice as well as seed germination and seedling growth of six different plants (Lolium, wheat, bean and common vetch, lettuce and canola)...
October 2015: Ecotoxicology and Environmental Safety
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