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Black cumin

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https://www.readbyqxmd.com/read/29657429/isolation-and-identification-of-bacteria-causing-mastitis-in-small-ruminants-and-their-susceptibility-to-antibiotics-honey-essential-oils-and-plant-extracts
#1
Abeer Mostafa Abdalhamed, Gamil Sayed Gamil Zeedan, Hala Abdoula Ahmed Abou Zeina
Aim: The present work aims to isolate and identify bacteria that cause mastitis in small ruminants and evaluates the antibacterial activity of some antibiotics, honey, essential oils, and plant extracts. Materials and Methods: A total of 289 milk samples were collected from udder secretions of sheep (n=189) and goat (n=100) from El-Fayoum, Beni-Suef, and Giza governorates. Screening subclinical mastitis (SCM) was done using California Mastitis Test (CMT); identification of the isolates was achieved using Gram's staining, hemolytic pattern, colony morphology, and biochemical tests using Analytical Profile Index...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29656006/par-4-dependent-p53-up-regulation-plays-a-critical-role-in-thymoquinone-induced-cellular-senescence-in-human-malignant-glioma-cells
#2
Karthikeyan Subburayan, Faisal Thayyullathil, Siraj Pallichankandy, Anees Rahman, Sehamuddin Galadari
Thymoquinone (TQ), the predominant bioactive constituent present in black cumin (Nigella sativa), exerts tumor suppressive activity against a wide variety of cancer cells. Cellular senescence, characterized by stable and long term loss of proliferative capacity, acts as a potent tumor suppressive mechanism. Here, we provide evidence for the first time that TQ suppresses growth of glioma cells by potentially inducing the expression of prostate apoptosis response-4 (Par-4) tumor suppressor protein. In turn, TQ-induced Par-4 expression triggers cellular senescence, as evidenced by increasing cellular size, β-galactosidase staining, G1 phase arrest, and increased expression of senescence markers such as p53, p21, Rb, and decreased expression of lamin B1, cyclin E and cyclin depended kinase-2 (CDK-2)...
April 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29648463/protective-effect-of-thymoquinone-the-main-component-of-nigella-sativa-against-diazinon-cardio-toxicity-in-rats
#3
Gholam Hassan Danaei, Bahram Memar, Ramin Ataee, Mohammad Karami
Several studies have shown that oxidative stress and cell damage can occur at very early stages of diazinon (DZN) exposure. The present study was designed to determine the beneficial effect of thymoquinone (Thy), the main component of Nigella sativa (black seed or black cumin), against DZN cardio-toxicity in rats. In the present experimental study, 48 male Wistar rats were randomly divided into six groups: control (corn oil gavages), DZN gavages (20 mg/kg/day), Thy gavages (10 mg/kg/day) and Thy + DVN gavages (2...
April 12, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29616559/urinary-bladder-stone-passing-using-a-persian-herbal-recipe
#4
Ayda Hosseinkhani, Fatemeh Tabatabaei, Maryam Mosaffa-Jahromi, Mehdi Pasalar
OBJECTIVE: The intrauterine device (IUD) is a popular contraceptive instrument with reported complications. IUD migration to the urinary bladder, a rare genitourinary tricky situation, may cause stone formation and result in urinary system sequels such as a stone formation and a recurrent infection. CASE REPORT: This is a case report of IUD migration to the urinary bladder, mineralization, and subsequent complications. We report the case of a 35-year-old woman with a copper IUD nidus stone in her urinary bladder...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29606771/effect-of-black-cumin-oil-on-the-oxidative-stability-and-sensory-characteristics-of-mayonnaise
#5
Necla Ozdemir, Meryem Nur Kantekin-Erdogan, Tuba Tat, Aziz Tekin
Mayonnaise is one of the most commonly used sauces all over the world but it is vulnerable to oxidation because of its high oil content. Using natural antioxidants instead of synthetic ones is a popular and promising topic in the food industry. The aim of this study was to increase the oxidative stability of mayonnaise using cold-pressed black cumin oil (BCO), which has high antioxidant activity due to its phenolic content. Four different mayonnaise formulations were used: Mayo-Control, Mayo-5% BCO, Mayo-10% BCO, and Mayo-20% BCO, which refer to a 0 (control), 5, 10, and 20% BCO replacement of total sunflower oil content, respectively...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29606758/some-microbiological-physicochemical-and-ripening-properties-of-erzincan-tulum-cheese-produced-with-added-black-cumin-nigella-sativa-l
#6
Yusuf Çakır, Songül Çakmakçı
The effects of black cumin (BC) at 0, 1 or 2% in Erzincan Tulum cheese (Tulum cheese) on its microbiological, chemical and proteolysis properties during ripening were investigated. The addition of BC caused an increase in the dry matter, protein, ash, total nitrogen (TN), water-soluble nitrogen (WSN) (% of TN) (ripening index), 5% phosphotungstic acid soluble nitrogen (PTA-SN) (% of TN), and 12% trichloroacetic acid soluble nitrogen (TCA-SN) (% of TN) concentrations compared to BC-free (control) cheese. Additionally, the addition of BC caused a decrease in coliforms, yeasts & moulds, fat-in-dry matter (FDM), pH, and acidity...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29604618/an-open-prospective-pilot-study-of-a-herbal-combination-relief-as-a-supportive-dietetic-measure-during-alcohol-withdrawal
#7
Kenza Mansoor, Fadi Qadan, Andreas Hinum, Caroline Schneider, Klaus Hechenbichler, Mathias Schmidt, Georg Linsinger, Khalid Matalka
OBJECTIVE: A herbal combination (saffron extract, passion flower herb extract, cocoa seed extract, radish extract and black cumin extract) called "Relief" was designed as a supportive therapy of alcohol withdrawal syndrome (AWS). This combination was based on the scientific evidence of each constituent effect on AWS-like symptoms. In addition, our preclinical studies have shown the effectiveness of Relief on AWS detoxification. The rationale of the study was to document whether the oral intake of the designed content of Relief could have a positive effect on the course of alcohol detoxification by reducing some of the AWS in hospitalized patients...
March 1, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29587770/powdered-black-cumin-seeds-strongly-improves-serum-lipids-atherogenic-index-of-plasma-and-modulates-anthropometric-features-in-patients-with-hashimoto-s-thyroiditis
#8
Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri
BACKGROUND: Hashimoto's thyroiditis is associated with serious alterations in serum lipids and glucose homeostasis. The aims of the current study were to evaluate the effect of powdered Nigella sativa on serum lipids, glucose homeostasis and anthropometric variables in patients with Hashimoto's thyroiditis. METHODS: Forty patients with Hashimoto's thyroiditis, aged between 22 and 50 years old, participated in the trial and were randomly allocated into two groups of intervention and control receiving powdered Nigella sativa or placebo daily for 8 weeks...
March 27, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29518971/dietary-plants-for-the-prevention-and-management-of-kidney-stones-preclinical-and-clinical-evidence-and-molecular-mechanisms
#9
REVIEW
Mina Cheraghi Nirumand, Marziyeh Hajialyani, Roja Rahimi, Mohammad Hosein Farzaei, Stéphane Zingue, Seyed Mohammad Nabavi, Anupam Bishayee
Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. Camellia sinensis (green tea), Rubus idaeus (raspberry), Rubia cordifolia (common madder), Petroselinum crispum (parsley), Punica granatum (pomegranate), Pistacia lentiscus (mastic), Solanum xanthocarpum (yellow-fruit nightshade), Urtica dioica (stinging nettle), Dolichos biflorus ( horse gram ), Ammi visnaga (khella), Nigella sativa (black-cumin), Hibiscus sabdariffa (roselle), and Origanum vulgare (oregano) have received considerable interest based on scientific evidence...
March 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29493013/carcass-characteristics-chemical-and-fatty-acid-composition-and-oxidative-stability-of-meat-from-broiler-chickens-fed-black-cumin-nigella-sativa-seeds
#10
P Kumar, A K Patra, G P Mandal, B C Debnath
A study was conducted to investigate the dietary supplementation of black cumin seeds (BCS) on carcass characteristics, chemical and fatty acid (FA) composition and antioxidant properties of thigh and breast meat of broiler chickens at 42 days of age. Three hundred sixty 1-day-old broiler chickens were allocated to five dietary treatment groups (each group containing eight replicate pens with each pen containing nine broiler chickens): basal diet (control; CON), CON + 0.05 g/kg of bacitracin methylene disalicylate (AB), CON + 5 g/kg of BCS (low dose of BCS), CON + 10 g/kg of BCS (medium dose of BCS) and CON + 20 g/kg of BCS (high dose of BCS)...
February 28, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29455727/enhancement-of-gut-permeation-of-amoxicillin-with-nigella-sativa-seed-extract-and-its-phytochemical-screening
#11
Babar Ali, Mohammad Ali, Saima Amin, Showkat R Mir
The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the gut wall. The methanolic extract of N. sativa improved intestinal permeability of amoxicillin in in-vitro experiments in a dose-dependent manner. Two new glycosides, decanyl nigelloic acid diglucoside [n-decanyl-3-aldehydic-4-methoxy-5-hydroxy benzoate-5-β-D-glucofuranosyl (2→1)-β-D-glucopyranosyl-(2→1)-β-D-glucopyranoside]] and nigelabdienoyl triglucoside [homo-labd-5, 9(11)-dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D-glucopyranoside], along with seven known fatty acid glycerides/esters, were isolated from the gut permeation enhancing extract...
February 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29433684/short-and-long-term-modulation-of-tissue-minerals-concentrations-following-oral-administration-of-black-cumin-nigella-sativa-l-seed-oil-to-laboratory-rats
#12
Irum Basheer, Irfan Zia Qureshi
BACKGROUND: Nigella sativa, or commonly called black cumin is a small herb of family Ranunculaceae is a well-known medicinal plant but its effects on tissue mineral concentrations of animal bodies is unknown. PURPOSE: To study the effect of oral administration of fixed oil of black cumin seeds on tissues mineral content using laboratory rats as experimental model. STUDY DESIGN: Experimental animals were exposed to two oral doses of seed oil (60 and 120 ml kg -1 body weight)...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29403626/a-review-of-effective-herbal-medicines-in-controlling-menopausal-symptoms
#13
REVIEW
Rahele Kargozar, Hoda Azizi, Roshanak Salari
Background: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. Objective: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29387368/the-influence-of-pulsed-electric-fields-and-microwave-pretreatments-on-some-selected-physicochemical-properties-of-oil-extracted-from-black-cumin-seed
#14
Hamid Bakhshabadi, HabibOllah Mirzaei, Alireza Ghodsvali, Seid Mahdi Jafari, Aman Mohammad Ziaiifar
Application of novel technologies such as microwave and pulsed electric fields (PEF) might increase the speed and efficiency of oil extraction. In the present research, PEF (3.25 kV/cm electric field intensity and 30 pulse number) and microwave (540 W for 180 s) pretreatments were used to study the process of oil extraction from black cumin (Nigella sativa) seeds. After applying the selected pretreatments, the oil of seeds was extracted with the use of a screw press and the extraction efficiency, refractive index, oil density, color index, oxidative stability, and chemical components of oil and protein of meal were evaluated...
January 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29318975/evaluation-of-the-antiproliferative-activity-of-some-nanoparticulate-essential-oils-formulated-in-microemulsion-on-selected-human-carcinoma-cell-lines
#15
Ahmed Abd-Rabou, Amr E Edris
BACKGROUND: Essential oils (EOs) are natural volatile plant extract that have different biological activities including antiproliferative potentials. OBJECTIVE: the current study aims at evaluating the antiproliferative activities of six EOs in their neat state compared to their nanoparticulate form after fabrication in microemulsion against some cancer cell lines. The EOs included marjoram (Origanum majorana), turmeric (Curcuma longa), sweet basil (Ocimum basillicum), clove buds (Syzygium aromaticum), geranium (plargonium graviolenis), and black cumin (Nigella sativa)...
January 10, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29223554/oral-administration-of-nigella-sativa-oil-and-thymoquinone-attenuates-long-term-cisplatin-treatment-induced-toxicity-and-oxidative-damage-in-rat-kidney
#16
Zeba Farooqui, Faaiza Shahid, Aijaz Ahmed Khan, Farah Khan
Cisplatin (CP) is an effective anti-cancer drug which causes remarkable toxicity to the kidney, particularly to proximal tubules, by generating reactive oxygen species. Nigella sativa (NS), commonly known as "black cumin" reduces the progression of various kidney disorders. Thymoquinone (TQ), the major bioactive constituent of NS seeds, has been credited for various pharmacological effects of NS. Since, a typical clinical CP dosing regimen involves CP administration in multiple cycles over a long time duration, hence the present study aimed to evaluate the renoprotective efficacy of NS oil and TQ against multiple dose CP treatment induced deleterious biochemical and histological alterations in rat kidney...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29203114/a-simultaneous-screening-and-quantitative-method-for-the-multiresidue-analysis-of-pesticides-in-spices-using-ultra-high-performance-liquid-chromatography-high-resolution-orbitrap-mass-spectrometry
#17
Arnab Goon, Zareen Khan, Dasharath Oulkar, Raviraj Shinde, Suresh Gaikwad, Kaushik Banerjee
A novel screening and quantitation method is reported for non-target multiresidue analysis of pesticides using ultra-HPLC-quadrupole-Orbitrap mass spectrometry in spice matrices, including black pepper, cardamom, chili, coriander, cumin, and turmeric. The method involved sequential full-scan (resolution = 70,000), and variable data independent acquisition (vDIA) with nine consecutive fragmentation events (resolution = 17,500). Samples were extracted by the QuEChERS method. The introduction of an SPE-based clean-up step through hydrophilic-lipophilic-balance (HLB) cartridges proved advantageous in minimizing the false negatives...
January 12, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29200724/bioassay-guided-isolation-of-neuroprotective-fatty-acids-from-nigella-sativa-against-1-methyl-4-phenylpyridinium-induced-neurotoxicity
#18
Leila Hosseinzadeh, Hoda Monaghash, Farahnaz Ahmadi, Nastaran Ghiasvand, Yalda Shokoohinia
Objective: Parkinson's disease, a slowly progressive neurological disease, is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine. The main aspects of researches are the protection of normal neurons against degeneration. Fatty acids (FAs), the key structural elements of dietary lipids, are carboxylic straight chains and notable parameters in nutritional and industrial usefulness of a plant. Materials and Methods: Black cumin, a popular anti-inflammatory and antioxidant food seasoning, contains nonpolar constituents such as FAs which were extracted using hexane...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29196013/the-potential-of-herbs-and-spices-to-reduce-lipid-oxidation-during-heating-and-gastrointestinal-digestion-of-a-beef-product
#19
T Van Hecke, P L Ho, S Goethals, S De Smet
Here we tested the potential of ten culinary herbs (basil, oregano, rosemary and thyme) and spices (black pepper, cayenne pepper, cumin, curcuma, garlic and sweet paprika) to limit oxidation during cooking of a high-fat beef product, and during its subsequent in vitro gastrointestinal digestion. The herbs and spices were added separately at 0.5% and 1% (w/w), either during meat processing before heating of the product or after heating of the meat as a seasoning. Lipid oxidation was evaluated by malondialdehyde, 4-hydroxy-2-nonenal and hexanal quantification in the meat products and gastrointestinal digests...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29178169/authentication-of-commercial-spices-based-on-the-similarities-between-gas-chromatographic-fingerprints
#20
Takaya Matsushita, Jing Jing Zhao, Noriyuki Igura, Mitsuya Shimoda
BACKGROUND: A simple and solvent-free method was developed for the authentication of commercial spices. The similarities between gas chromatographic fingerprints were measured using similarity indices and multivariate data analyses, as morphological differentiation between dried powders and small spice particles was challenging. The volatile compounds present in 11 spices (i.e. allspice, anise, black pepper, caraway, clove, coriander, cumin, dill, fennel, star anise, and white pepper) were extracted by headspace solid-phase microextraction, and analysed by gas chromatography-mass spectrometry...
November 27, 2017: Journal of the Science of Food and Agriculture
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