Read by QxMD icon Read


Juan Sebastian Yakisich, Neelam Azad, Vivek Kaushik, Anand Krishnan V Iyer
In cancer cells, the reversible nature of the stemness status in terms of chemoresistance has been poorly characterized. In this study, we have simulated on cycle of environmental conditions to study such reversibility by first generating floating tumorspheres (FTs) from lung and breast cancer cells by culturing them in serum-free media without the addition of any external mitogenic stimulation, and subsequently (after two weeks) re-incubating them back in serum-containing media to simulate routine culture conditions (RCCs)...
December 7, 2016: Journal of Cellular Physiology
Iwona Rotter, Karolina Skonieczna-Żydecka, Danuta Kosik-Bogacka, Grażyna Adler, Aleksandra Rył, Maria Laszczyńska
PURPOSE: Metabolic disorders, including MetS, obesity, and lipid disorders, may be related to genetic factors. Metabolic disorders are associated with decreased TS levels in aging men. The aim of this study was to evaluate the relationship between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the presence of MetS and its components, the concurrent lipid disorders, as well as sex hormone concentrations. SUBJECTS AND METHODS: This study involved 272 men of Caucasian descent aged 50-75 years...
2016: Clinical Interventions in Aging
Jie Gao, Peiyong Zhu, Ahmed Alsaedi, Fuad E Alsaadi, Tasawar Hayat
In this paper, finite-time synchronization (FTS) of memristor-based recurrent neural networks (MNNs) with time-varying delays is investigated by designing a new switching controller. First, by using the differential inclusions theory and set-valued maps, sufficient conditions to ensure FTS of MNNs are obtained under the two cases of 0<α<1 and α=0, and it is derived that α=0 is the critical value of 0<α<1. Next, it is discussed deeply on the relation between the parameter α and the synchronization time...
November 4, 2016: Neural Networks: the Official Journal of the International Neural Network Society
O A Wolf, M Imgrund, G Wess
BACKGROUND: False tendons (FTs) are string-like structures in the left ventricle. A FT might produce focal thickening at its insertion region of the left ventricle, which could be mistaken for focal hypertrophic cardiomyopathy. OBJECTIVES: To perform a prospective, echocardiographic follow-up examination of feline FTs and compare the wall thickness at the FT insertion region and a normal region without FTs at both examinations. ANIMALS: One hundred twenty-eight cats with one or multiple FTs without other cardiac abnormalities or systemic disease...
November 16, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Petra Spidlova, Iva Senitkova, Marek Link, Jiri Stulik
Francisella tularensis is a highly virulent intracellular pathogen with the capacity to infect a variety of hosts including humans. One of the most important proteins involved in F. tularensis virulence and pathogenesis is the protein DsbA. This protein is annotated as a lipoprotein with disulfide oxidoreductase/isomerase activity. Therefore, its interactions with different substrates, including probable virulence factors, to assist in their proper folding are anticipated. We aimed to use the immunopurification approach to find DsbA (gene locus FTS_1067) interacting partners in F...
November 15, 2016: Acta Microbiologica et Immunologica Hungarica
Nobuko Sumiya, Takayuki Fujiwara, Atsuko Era, Shin-Ya Miyagishima
Chloroplasts evolved from a cyanobacterial endosymbiont. It is believed that the synchronization of endosymbiotic and host cell division, as is commonly seen in existing algae, was a critical step in establishing the permanent organelle. Algal cells typically contain one or only a small number of chloroplasts that divide once per host cell cycle. This division is based partly on the S-phase-specific expression of nucleus-encoded proteins that constitute the chloroplast-division machinery. In this study, using the red alga Cyanidioschyzon merolae, we show that cell-cycle progression is arrested at the prophase when chloroplast division is blocked before the formation of the chloroplast-division machinery by the overexpression of Filamenting temperature-sensitive (Fts) Z2-1 (Fts72-1), but the cell cycle progresses when chloroplast division is blocked during division-site constriction by the overexpression of either FtsZ2-1 or a dominant-negative form of dynamin-related protein 5B (DRP5B)...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
Korneel H Cats, Bert M Weckhuysen
A novel laboratory setup for combined operando X-ray diffraction and Raman spectroscopy of catalytic solids with online product analysis by gas chromatography is presented. The setup can be used with a laboratory-based X-ray source, which results in important advantages in terms of time-on-stream that can be measured, compared to synchrotron-based experiments. The data quality was much improved by the use of a relatively high-energy MoKα radiation instead of the more conventional CuKα radiation. We have applied the instrument to study the long-term deactivation of Co/TiO2 Fischer-Tropsch synthesis (FTS) catalysts...
April 20, 2016: ChemCatChem
Xavier Dauchy, Virginie Boiteux, Cristina Bach, Adeline Colin, Jessica Hemard, Christophe Rosin, Jean-François Munoz
Although industrial sites producing perfluoroalkyl and polyfluoroalkyl substances (PFASs) may introduce these chemicals into the aquatic environment, they are rarely investigated. This study entailed measuring concentrations, mass flows and the fate of 51 PFASs in an industrial wastewater treatment plant receiving raw effluents from a fluorochemical manufacturing facility. Grab and 24-h composite samples were collected at various stages of wastewater treatment over four sampling campaigns. One perfluoroalkyl carboxylic acid (PFCA) and nine fluorotelomers (FTs) were systematically detected in the facility's raw effluent...
October 27, 2016: Science of the Total Environment
Behzad Sardari, Federico Davoli, Meriç Özcan
In this work a new broadband static Fourier transform spectrometer (static-FTS) configuration based on the division of the spectrum into multiple narrow-bands is proposed. This configuration not only decreases the spectrometer size but also allows operation in the traditional spectrometer wavelength range, namely, 400 nm-1100 nm with 1 cm(-1) or better resolution. This technique solves the Nyquist sampling rate issue and enables us to record high resolution spectrums with regular CCDs. An algorithm is developed to process the signal and calculate the Fourier transform of the recorded interferograms on the CCD camera...
October 2016: Review of Scientific Instruments
Bassem Refaat, Jawwad Ahmad, Shakir Idris, Fadi Fayez Kamfar, Ahmed Mohamed Ashshi, Sarah Abdullah Batwa, Faizah Ahmed Malibary
This is a prospective observational study that measures the expression of vitamin D (VD) metabolising and signalling molecules and Ca(2+) sensing receptor (CaSR) in human Fallopian tube (FT) during the menstrual cycle and ectopic pregnancy (EP). Fresh FTs were obtained during total abdominal hysterectomy at the follicular (n = 16) and midluteal (n = 16) phases. Specimens from remote and implantation sites as well as trophoblastic tissues were also freshly collected from each FT with EP (n = 10)...
October 22, 2016: Cell and Tissue Research
Yu-Tse Wu, Meng-Ting Cai, Chih-Wei Chang, Ching-Chi Yen, Mei-Chich Hsu
An analytical method entailing high-performance liquid chromatography coupled with electrochemical detection was developed for determining forsythiaside (FTS) in rat plasma. Rat plasma samples were prepared through efficient trichloroacetic acid deproteination. FTS and the internal standard were chromatographically separated on a reversed-phase core-shell silica C18 column (100 mm × 2.1 mm, i.d. 2.6 μm), with a mobile phase consisting of an acetonitrile-0.05-M phosphate solution (11.8:88.2, v/v), at a flow rate of 400 μL/min...
October 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ban Xuan Dong, Jojo A Amonoo, Geoffrey E Purdum, Yueh-Lin Loo, Peter F Green
Charge-carrier mobilities in poly(3-hexylthiophene) (P3HT) organic thin-film transistors (OTFTs) increase 5-fold when OTFTs composed of P3HT films on trichloro (1H, 1H, 2H, 2H-perfluorooctyl) silane (FTS) monolayers supported on SiO2 dielectric substrates (P3HT/FTS/SiO2/Si) are subjected to supercritical carbon dioxide (scCO2) processing. In contrast, carrier mobilities in P3HT/octadecyltrichlorosilane (OTS)/SiO2 OTFTs processed using scCO2 are comparable to mobilities measured in as-cast P3HT/OTS/SiO2/Si devices...
November 3, 2016: ACS Applied Materials & Interfaces
Guangxiang Wen, Qiang Wang, Riguang Zhang, Debao Li, Baojun Wang
The initiation, growth and termination mechanism of the C-C chain from syngas on the Co(0001) surface have been investigated using DFT calculations. Our results show that CHx (x = 1-3) formation is easier than CH3OH, both CH and CH2 species are the dominant forms of CHx (x = 1-3), both CH and CH2 species dominantly interact with CHO to form CHCHO and CH2CHO, and realizes the initial C-C chain formation. Then, CHCHO and CH2CHO prefer to be successively hydrogenated to CH3CHO, followed by C-O bond cleavage to give CH3CH; subsequently, CHO insertion into CH3CH can realize the further chain growth to form CH3CHCHO, followed by dissociation and hydrogenation to give CH3CHCH and CH3CH2CHO, respectively; further, CH3CHCH hydrogenation or CH3CH2CHO dissociation via the C-O bond cleavage can form the CH3CH-like species CH3CH2CH intermediate...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
Yueliang Zhao, Daming Fan, Beibei Ru, Ka-Wing Cheng, Shuting Hu, Jiangwen Zhang, Edmund T S Li, Mingfu Wang
6-C-(E-phenylethenyl)naringenin (6-CEPN) is a small molecule found in naringenin fortified fried beef. It has been shown to suppress colon cancer cell proliferation, but the underlying mechanisms are not fully understood. Here we demonstrate that 6-CEPN suppresses tumour cell proliferation through cell cycle arrest in G1 phase, induces necrotic cell death and autophagy in colon cancer cells. Blockade of autophagy by knockdown of the essential autophagy proteins, Atg7 or beclin-1, resulted in aggravated cell death in response to 6-CEPN treatment...
October 3, 2016: European Journal of Cancer
Wei Wang, Jiapin Chen, Aleksandar S Zivkovic, Huikai Xie
A Fourier transform spectrometer (FTS) that incorporates a closed-loop controlled, electrothermally actuated microelectromechanical systems (MEMS) micromirror is proposed and experimentally verified. The scan range and the tilting angle of the mirror plate are the two critical parameters for MEMS-based FTS. In this work, the MEMS mirror with a footprint of 4.3 mm × 3.1 mm is based on a modified lateral-shift-free (LSF) bimorph actuator design with large piston and reduced tilting. Combined with a position-sensitive device (PSD) for tilt angle sensing, the feedback controlled MEMS mirror generates a 430 µm stable linear piston scan with the mirror plate tilting angle less than ±0...
2016: Sensors
Jessica E Ackerman, Alayna E Loiselle
Tendon connects skeletal muscle and bone, facilitating movement of nearly the entire body. In the hand, flexor tendons (FTs) enable flexion of the fingers and general hand function. Injuries to the FTs are common, and satisfactory healing is often impaired due to excess scar tissue and adhesions between the tendon and surrounding tissue. However, little is known about the molecular and cellular components of FT repair. To that end, a murine model of FT repair that recapitulates many aspects of healing in humans, including impaired range of motion and decreased mechanical properties, has been developed and previously described...
2016: Journal of Visualized Experiments: JoVE
Kazumi Yamaguchi, Yusuke Niwa, Takakazu Nakabayashi, Hirotsugu Hiramatsu
Ras protein is involved in a signal transduction cascade in cell growth, and cluster formation of H-Ras and human galectin-1 (Gal-1) complex is considered to be crucial to achieve its physiological roles. It is considered that the complex is formed through interactions between Gal-1 and the farnesyl group (farnesyl-dependent model), post-translationally modified to the C-terminal Cys, of H-Ras. We investigated the role of farnesyl-bound Gal-1 in the cluster formation by analyzing the structure and properties of Gal-1 bound to farnesyl thiosalicylic acid (FTS), a competitive inhibitor of the binding of H-Ras to Gal-1...
2016: Scientific Reports
Vasileios I Metaxas, Gerasimos A Messaris, George D Gatzounis, George S Panayiotakis
Cervical discectomy and fusion (CDF) is a minimally invasive procedure, where the accurate placement of the implants is accomplished using fluoroscopic guidance. Therefore, the evaluation of the radiation dose becomes mandatory. The purpose of the current study was to assess patient dose during fluoroscopically guided anterior and/or posterior CDF procedures. Thirty-three patients undergoing single or multiple-level CDF were studied using a mobile C-arm system. Data regarding fluoroscopy time (FT), air kerma area product (KAP) and cumulative dose (CD) were recorded...
September 9, 2016: Radiation Protection Dosimetry
Marta Castro-Rodríguez, José A Carnicero, Francisco J Garcia-Garcia, Stephan Walter, John E Morley, Fernando Rodríguez-Artalejo, Alan J Sinclair, L Rodríguez-Mañas
OBJECTIVES: To assess the role of frailty in predicting death and incident disability in older adults with type 2 diabetes mellitus. DESIGN: Prospective cohort study. SETTING: Community dwelling. PARTICIPANTS: A total of 1825 individuals ≥65 years old recruited between June 2006 and September 2009 were followed for a median of 5.5 years for mortality and 4.98 years for incident functional disability in activities of daily living...
October 1, 2016: Journal of the American Medical Directors Association
Wei Wei, Meng Wang, Donghai Li, Min Zuo, Xiaoyi Wang
In this paper, synchronization of a three-dimensional energy resource chaotic system is considered. For the sake of achieving the synchronization between the drive and response systems, two different nonlinear control approaches, i.e. active control with known parameters and adaptive control with unknown parameters, have been designed. In order to guarantee the transient performance, finite-time boundedness (FTB) and finite-time stability (FTS) are introduced in the design of active control and adaptive control, respectively...
August 31, 2016: ISA Transactions
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"