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Bassem Refaat, Jawwad Ahmad, Shakir Idris, Fadi Fayez Kamfar, Ahmed Mohamed Ashshi, Sarah Abdullah Batwa, Faizah Ahmed Malibary
This is a prospective observational study that measures the expression of vitamin D (VD) metabolising and signalling molecules and Ca(2+) sensing receptor (CaSR) in human Fallopian tube (FT) during the menstrual cycle and ectopic pregnancy (EP). Fresh FTs were obtained during total abdominal hysterectomy at the follicular (n = 16) and midluteal (n = 16) phases. Specimens from remote and implantation sites as well as trophoblastic tissues were also freshly collected from each FT with EP (n = 10)...
October 22, 2016: Cell and Tissue Research
Yu-Tse Wu, Meng-Ting Cai, Chih-Wei Chang, Ching-Chi Yen, Mei-Chich Hsu
An analytical method entailing high-performance liquid chromatography coupled with electrochemical detection was developed for determining forsythiaside (FTS) in rat plasma. Rat plasma samples were prepared through efficient trichloroacetic acid deproteination. FTS and the internal standard were chromatographically separated on a reversed-phase core-shell silica C18 column (100 mm × 2.1 mm, i.d. 2.6 μm), with a mobile phase consisting of an acetonitrile-0.05-M phosphate solution (11.8:88.2, v/v), at a flow rate of 400 μL/min...
October 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ban Xuan Dong, Jojo A Amonoo, Geoffrey E Purdum, Yueh-Lin Loo, Peter F Green
Charge-carrier mobilities in poly(3-hexylthiophene) (P3HT) organic thin-film transistors (OTFTs) increase five-fold when OTFTs composed of P3HT films on trichloro (1H, 1H, 2H, 2H-perfluorooctyl) silane (FTS) monolayers supported on SiO2 dielectric substrates (P3HT/FTS/SiO2/Si) are subjected to supercritical carbon dioxide (scCO2) processing. In contrast, carrier mobilities in P3HT/octadecyltrichlorosilane (OTS)/SiO2 OTFTs processed using scCO2 are comparable to mobilities measured in as-cast P3HT/OTS/SiO2/Si devices...
October 17, 2016: ACS Applied Materials & Interfaces
Guangxiang Wen, Qiang Wang, Riguang Zhang, Debao Li, Baojun Wang
The initiation, growth and termination mechanism of the C-C chain from syngas on the Co(0001) surface have been investigated using DFT calculations. Our results show that CHx (x = 1-3) formation is easier than CH3OH, both CH and CH2 species are the dominant forms of CHx (x = 1-3), both CH and CH2 species dominantly interact with CHO to form CHCHO and CH2CHO, and realizes the initial C-C chain formation. Then, CHCHO and CH2CHO prefer to be successively hydrogenated to CH3CHO, followed by C-O bond cleavage to give CH3CH; subsequently, CHO insertion into CH3CH can realize the further chain growth to form CH3CHCHO, followed by dissociation and hydrogenation to give CH3CHCH and CH3CH2CHO, respectively; further, CH3CHCH hydrogenation or CH3CH2CHO dissociation via the C-O bond cleavage can form the CH3CH-like species CH3CH2CH intermediate...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
Yueliang Zhao, Daming Fan, Beibei Ru, Ka-Wing Cheng, Shuting Hu, Jiangwen Zhang, Edmund T S Li, Mingfu Wang
6-C-(E-phenylethenyl)naringenin (6-CEPN) is a small molecule found in naringenin fortified fried beef. It has been shown to suppress colon cancer cell proliferation, but the underlying mechanisms are not fully understood. Here we demonstrate that 6-CEPN suppresses tumour cell proliferation through cell cycle arrest in G1 phase, induces necrotic cell death and autophagy in colon cancer cells. Blockade of autophagy by knockdown of the essential autophagy proteins, Atg7 or beclin-1, resulted in aggravated cell death in response to 6-CEPN treatment...
October 3, 2016: European Journal of Cancer
Wei Wang, Jiapin Chen, Aleksandar S Zivkovic, Huikai Xie
A Fourier transform spectrometer (FTS) that incorporates a closed-loop controlled, electrothermally actuated microelectromechanical systems (MEMS) micromirror is proposed and experimentally verified. The scan range and the tilting angle of the mirror plate are the two critical parameters for MEMS-based FTS. In this work, the MEMS mirror with a footprint of 4.3 mm × 3.1 mm is based on a modified lateral-shift-free (LSF) bimorph actuator design with large piston and reduced tilting. Combined with a position-sensitive device (PSD) for tilt angle sensing, the feedback controlled MEMS mirror generates a 430 µm stable linear piston scan with the mirror plate tilting angle less than ±0...
2016: Sensors
Jessica E Ackerman, Alayna E Loiselle
Tendon connects skeletal muscle and bone, facilitating movement of nearly the entire body. In the hand, flexor tendons (FTs) enable flexion of the fingers and general hand function. Injuries to the FTs are common, and satisfactory healing is often impaired due to excess scar tissue and adhesions between the tendon and surrounding tissue. However, little is known about the molecular and cellular components of FT repair. To that end, a murine model of FT repair that recapitulates many aspects of healing in humans, including impaired range of motion and decreased mechanical properties, has been developed and previously described...
2016: Journal of Visualized Experiments: JoVE
Kazumi Yamaguchi, Yusuke Niwa, Takakazu Nakabayashi, Hirotsugu Hiramatsu
Ras protein is involved in a signal transduction cascade in cell growth, and cluster formation of H-Ras and human galectin-1 (Gal-1) complex is considered to be crucial to achieve its physiological roles. It is considered that the complex is formed through interactions between Gal-1 and the farnesyl group (farnesyl-dependent model), post-translationally modified to the C-terminal Cys, of H-Ras. We investigated the role of farnesyl-bound Gal-1 in the cluster formation by analyzing the structure and properties of Gal-1 bound to farnesyl thiosalicylic acid (FTS), a competitive inhibitor of the binding of H-Ras to Gal-1...
2016: Scientific Reports
Vasileios I Metaxas, Gerasimos A Messaris, George D Gatzounis, George S Panayiotakis
Cervical discectomy and fusion (CDF) is a minimally invasive procedure, where the accurate placement of the implants is accomplished using fluoroscopic guidance. Therefore, the evaluation of the radiation dose becomes mandatory. The purpose of the current study was to assess patient dose during fluoroscopically guided anterior and/or posterior CDF procedures. Thirty-three patients undergoing single or multiple-level CDF were studied using a mobile C-arm system. Data regarding fluoroscopy time (FT), air kerma area product (KAP) and cumulative dose (CD) were recorded...
September 9, 2016: Radiation Protection Dosimetry
Marta Castro-Rodríguez, José A Carnicero, Francisco J Garcia-Garcia, Stephan Walter, John E Morley, Fernando Rodríguez-Artalejo, Alan J Sinclair, L Rodríguez-Mañas
OBJECTIVES: To assess the role of frailty in predicting death and incident disability in older adults with type 2 diabetes mellitus. DESIGN: Prospective cohort study. SETTING: Community dwelling. PARTICIPANTS: A total of 1825 individuals ≥65 years old recruited between June 2006 and September 2009 were followed for a median of 5.5 years for mortality and 4.98 years for incident functional disability in activities of daily living...
October 1, 2016: Journal of the American Medical Directors Association
Wei Wei, Meng Wang, Donghai Li, Min Zuo, Xiaoyi Wang
In this paper, synchronization of a three-dimensional energy resource chaotic system is considered. For the sake of achieving the synchronization between the drive and response systems, two different nonlinear control approaches, i.e. active control with known parameters and adaptive control with unknown parameters, have been designed. In order to guarantee the transient performance, finite-time boundedness (FTB) and finite-time stability (FTS) are introduced in the design of active control and adaptive control, respectively...
August 31, 2016: ISA Transactions
Ahmed A M Abdel-Hamid, Yaser Mesbah, Mona F M Soliman
Letrozole (LTZ), one of the ovulation induction medications, is increasingly prescribed in various gynaecological conditions. Previous studies have demonstrated its potential hazardous effect on the ovarian surface epithelium (OSE) as well as on tubal epithelial cells (TEC). However, it is not clear whether this effect could be reversed by LTZ cessation. Therefore, the objective of our study was to investigate the effect of stoppage of LTZ on these cells after 12 cycles of ovarian stimulation. A total of 54 Sprague Dawley rats were used in this study, divided equally into control, LTZ12 and CES12 groups (received saline, 12 cycles of LTZ and 12 cycles of cessation post-LTZ12 respectively)...
August 2016: International Journal of Experimental Pathology
Sandy Gim Ming Ong, Long Chiau Ming, Kah Seng Lee, Kah Hay Yuen
The objective of the present study was to investigate the influence of the encapsulation efficiency and size of liposome on the oral bioavailability of griseofulvin-loaded liposomes. Griseofulvin-loaded liposomes with desired characteristics were prepared from pro-liposome using various techniques. To study the effect of encapsulation efficiency, three preparations of griseofulvin, namely, griseofulvin aqueous suspension and two griseofulvin-loaded liposomes with different amounts of griseofulvin encapsulated [i...
August 26, 2016: Pharmaceutics
Xiaoli Guo, Ginny G Farías, Rafael Mattera, Juan S Bonifacino
An open question in cell biology is how the general intracellular transport machinery is adapted to perform specialized functions in polarized cells such as neurons. Here we illustrate this adaptation by elucidating a role for the ubiquitous small GTPase Ras-related protein in brain 5 (Rab5) in neuronal polarity. We show that inactivation or depletion of Rab5 in rat hippocampal neurons abrogates the somatodendritic polarity of the transferrin receptor and several glutamate receptor types, resulting in their appearance in the axon...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
Jennifer B Korosi, Colin A Cooke, David C Eickmeyer, Linda E Kimpe, Jules M Blais
Most future growth in the Alberta bituminous sands will be based on thermal in-situ recovery technologies. To date, however, most attention on the environmental effects of bitumen recovery has focused on surface mining in the Athabasca region. Recent uncontrolled bitumen flow-to-surface incidents (FTS; appearance at the surface of bitumen emulsions from deep subsurface recovery zones) reported at the Cold Lake heavy oil fields highlight the need to better understand the potential role of in-situ extraction as a source of contaminants to landscapes and surface waters...
November 2016: Environmental Pollution
Prabakaran D Subramanian, Zhengzhe An, Jae-Ran Yu, Woo-Yoon Park
PURPOSE: Overexpression of epidermal growth factor receptor (EGFR) is related to chemo-/radioresistance and poor prognosis in many cancers. EGFR is activated by cisplatin, and this may lead to resistance to this drug. Fused toes homolog (FTS) is an E2 variant that lacks the active cysteine residue required for ubiquitin transfer. Previously, we reported that FTS interacts with EGFR and activates DNA-dependent protein kinase (DNA-PK) upon irradiation. Here, we investigated the role of FTS in cisplatin sensitivity in ME180 cervical cancer cells...
October 2016: Cancer Chemotherapy and Pharmacology
Jinhua Feng, Ka Li, Li Li, Xiaodong Wang, Mingjun Huang, Jie Yang, Yanjie Hu
OBJECTIVE: The objective of this study is to explore the effects of the fast-track surgery (FTS) program on inflammation and immunity in patients undergoing colorectal surgery. METHODS: From August 2014 to March 2015, a prospective and randomized controlled trial of 230 patients who underwent colorectal surgery was performed. The patients were randomly assigned to an FTS group (116 patients) or a traditional group (114 patients). Inflammatory mediators, immunological indicators, postoperative recovery indexes, and complications were compared between the two groups...
October 2016: International Journal of Colorectal Disease
Bassem Refaat, Ahmed Mohamed Ashshi, Sarah Abdullah Batwa, Jawwad Ahmad, Shakir Idris, Seham Yahia Kutbi, Faizah Ahmed Malibary, Fadi Fayez Kamfar
This was a prospective case-control study that measured the prevalence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG) by an IVD CE multiplex PCR kit in fresh Fallopian tubes (FT) obtained from 96 ectopic pregnancies (EP) and 61 controls in the midluteal phase of the cycle. We later measured the expression profile of IL-6, leukaemia inhibitory factor (LIF) and their signalling molecules, in respect to the type and number of infections, by immunohistochemistry, ELISA and quantitative RT-PCR...
October 2016: Innate Immunity
V-S Todorovic, M Vasovic, M Andric, L Todorovic, V Kokovic
BACKGROUND: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. MATERIAL AND METHODS: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study...
2016: Medicina Oral, Patología Oral y Cirugía Bucal
Ikuma Kato, Akihiko Yoshida, Masachika Ikegami, Tomotake Okuma, Akiko Tonooka, Shinichiro Horiguchi, Nobuaki Funata, Akira Kawai, Takahiro Goto, Tsunekazu Hishima, Ichiro Aoki, Toru Motoi
AIMS: Although desmoplastic fibroblastoma (DFB) and fibroma of tendon sheath (FTS) are well-established entities, they may show overlapping clinicopathological features. In addition, cytogenetic data showing a shared 11q12 rearrangement in a small number of cases suggest a close link between these entities. A recent microarray study revealed upregulation of FOSL1 mRNA in DFBs with 11q12 rearrangement. The aim of this study was to clarify the relationship between DFB and FTS. METHODS AND RESULTS: We tested 42 cases originally diagnosed as either DFBs or FTSs for interobserver concordance based on the existing histological criteria and correlated the diagnosis with FOSL1 immunohistochemistry...
July 21, 2016: Histopathology
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