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F Chen, K Gaitskell, M J Garcia, A Albukhari, J Tsaltas, A A Ahmed
BACKGROUND: Serous tubal intraepithelial carcinomas (STICs) have been documented in high-grade serous ovarian carcinomas (HGSOCs). However, the rate of association between STICs and HGSOCs and, therefore, the fraction of HGSOCs that are likely to have originated from the fallopian tube (FT), has remained unclear. OBJECTIVE: To appraise the literature describing the association between STICs and established HGSOCs. SEARCH STRATEGY: Ovid MEDLINE and EMBASE were searched...
February 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
R Liu, W Damman, M Reijnierse, J L Bloem, F R Rosendaal, M Kloppenburg
OBJECTIVE: To determine the association between bone marrow lesions (BMLs) and (teno)synovitis as assessed on magnetic resonance (MR) imaging in patients with pain in hand osteoarthritis (OA). METHODS: In 105 consecutive primary hand OA patients (83% women, mean age 59 years), who were diagnosed by rheumatologists and included in the HOSTAS (Hand OSTeoArthritis in Secondary care) cohort, contrast-enhanced MR imaging of right distal and proximal interphalangeal joints were obtained...
February 12, 2017: Osteoarthritis and Cartilage
Tim A Wezendonk, Quirinus S E Warringa, Vera P Santos, Adam Chojecki, Matthijs Ruitenbeek, Garry Meima, Michiel Makkee, Freek Kapteijn, Jorge Gascon
The structure and elementary composition of various commercial Fe-based MOFs used as precursors for Fischer-Tropsch synthesis (FTS) catalysts have a large influence on the high-temperature FTS activity and selectivity of the resulting Fe on carbon composites. The selected Fe-MOF topologies (MIL-68, MIL-88A, MIL-100, MIL-101, MIL-127, and Fe-BTC) differ from each other in terms of porosity, surface area, Fe and heteroatom content, crystal density and thermal stability. They are re-engineered towards FTS catalysts by means of simple pyrolysis at 500 °C under a N2 atmosphere and afterwards characterized in terms of porosity, crystallite phase, bulk and surface Fe content, Fe nanoparticle size and oxidation state...
February 14, 2017: Faraday Discussions
Pieter van Helden, Jan-Albert van den Berg, Melissa A Petersen, Werner Janse van Rensburg, Ionel M Ciobîcă, Jan van de Loosdrecht
A multi-site microkinetic model for the Fischer-Tropsch synthesis (FTS) reaction up to C2 products on a FCC cobalt catalyst surface is presented. This model utilizes a multi-faceted cobalt nanoparticle model for the catalyst, consisting of the two dominant cobalt surface facets Co(111) and Co(100), and a step site represented by the Co(211) surface. The kinetic parameters for the intermediates and transition states on these sites were obtained using plane-wave, periodic boundary condition density functional theory...
February 10, 2017: Faraday Discussions
Peng Zhai, Pei-Pei Chen, Jinglin Xie, Jin-Xun Liu, Huabo Zhao, Lili Lin, Bo Zhao, Hai-Yan Su, Qingjun Zhu, Wei-Xue Li, Ding Ma
Various carbonaceous species were controllably deposited on Co/Al2O3 catalysts using ethylene as carbon source during the activation process for Fischer-Tropsch synthesis (FTS). Atomic, polymeric and graphitic carbon were distinguished by Raman spectroscopy, thermoanalysis and temperature programmed hydrogenation. Significant changes occurred in both the catalytic activity and selectivity toward hydrocarbon products after ethylene treatment. The activity decreased along with an increase in CH4 selectivity, at the expense of a remarkable decrease of heavy hydrocarbon production, resulting in enhanced selectivity for the gasoline fraction...
February 10, 2017: Faraday Discussions
Liping Wu, Yilin Pang, Guiqi Qin, Gaina Xi, Shengnan Wu, Xiaoping Wang, Tongsheng Chen
Dihydroartemisinin (DHA) and artesunate (ARS), two artemisinin derivatives, have efficacious anticancer activities against human hepatocarcinoma (HCC) cells. This study aims to study the anticancer action of the combination treatment of DHA/ARS and farnesylthiosalicylic acid (FTS), a Ras inhibitor, in HCC cells (Huh-7 and HepG2 cell lines). FTS pretreatment significantly enhanced DHA/ARS-induced phosphatidylserine (PS) externalization, Bak/Bax activation, mitochondrial membrane depolarization, cytochrome c release, and caspase-8 and -9 activations, characteristics of the extrinsic and intrinsic apoptosis...
2017: PloS One
C J Weststrate, J W Niemantsverdriet
Monomeric forms of carbon play a central role in the synthesis of long chain hydrocarbons via the Fischer-Tropsch synthesis (FTS). We explored the chemistry of C1Hxad species on the close-packed surface of cobalt. Our findings on this simple model catalyst highlight the important role of surface hydrogen and vacant sites for product selectivity. We furthermore find that COad affects hydrogen in multiple ways. It limits the adsorption capacity for Had, lowers its adsorption energy and inhibits dissociative H2 adsorption...
February 7, 2017: Faraday Discussions
Eran Schmukler, Eya Wolfson, Zvulun Elazar, Yoel Kloog, Ronit Pinkas-Kramarski
High percentage of human cancers involves alteration or mutation in Ras proteins, including the most aggressive malignancies, such as lung, colon and pancreatic cancers. FTS (Salirasib) is a farnesylcysteine mimetic, which acts as a functional Ras inhibitor, and was shown to exert anti-tumorigenic effects in vitro and in vivo. Previously, we have demonstrated that short-term treatment with FTS also induces protective autophagy in several cancer cell lines. Drug resistance is frequently observed in cancer cells exposed to prolonged treatment, and is considered a major cause for therapy inefficiency...
2017: PloS One
Hsian-Jenn Wang, Lin-Gwei Wei, Chi-Hsien Wang, Ya-Chen Cheng, Junn-Liang Chang, Tai-Li Tsou, Chih-Hung Ku, Chun-Chang Li, Wen-Kuan Chiu, Chieh-Feng Chen
BACKGROUND: Although tendon-exposed or bone-exposed wounds can be resurfaced with flaps, such surgeries may not be feasible in patients with poor general or local conditions. Biosynthetic artificial skin is an alternative for critical wound coverage. We designed a new artificial skin bilayer to close difficult wounds permanently. AIM AND OBJECTIVES: This study compares incorporation and wound contraction between silicone acellular porcine dermis (SAPD) and the Integra graft (Integra Life Sciences Corp...
January 27, 2017: Annals of Plastic Surgery
Virginie Boiteux, Xavier Dauchy, Cristina Bach, Adeline Colin, Jessica Hemard, Véronique Sagres, Christophe Rosin, Jean-François Munoz
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are emerging contaminants that have been detected in the environment, biota and humans. Drinking water is a route of exposure for populations using water contaminated by PFAS discharges. This research entailed measuring concentrations, mass flows and investigating the fate of dozens PFASs in a river receiving effluents from a fluorochemical manufacturing facility. To measure the total concentration of perfluoroalkyl carboxylic acid (PFCA) precursors, an oxidative conversion method was used...
January 20, 2017: Science of the Total Environment
Zhiwen Yu, Zhiqiang Wang, Jane You, Jun Zhang, Jiming Liu, Hau-San Wong, Guoqiang Han
Nonparametric statistical analysis, such as the Friedman test (FT), is gaining more and more attention due to its useful applications in a lot of experimental studies. However, traditional FT for the comparison of multiple learning algorithms on different datasets adopts the naive ranking approach. The ranking is based on the average accuracy values obtained by the set of learning algorithms on the datasets, which neither considers the differences of the results obtained by the learning algorithms on each dataset nor takes into account the performance of the learning algorithms in each run...
October 3, 2016: IEEE Transactions on Cybernetics
O Lupan, V Postica, J Gröttrup, A K Mishra, N H de Leeuw, J F C Carreira, J Rodrigues, N Ben Sedrine, M R Correia, T Monteiro, V Cretu, I Tiginyanu, D Smazna, Y K Mishra, R Adelung
In this work, the exceptionally improved sensing capability of highly porous three-dimensional (3-D) hybrid ceramic networks toward reducing gases is demonstrated for the first time. The 3-D hybrid ceramic networks are based on doped metal oxides (MexOy and ZnxMe1-xOy, Me = Fe, Cu, Al) and alloyed zinc oxide tetrapods (ZnO-T) forming numerous junctions and heterojunctions. A change in morphology of the samples and formation of different complex microstructures is achieved by mixing the metallic (Fe, Cu, Al) microparticles with ZnO-T grown by the flame transport synthesis (FTS) in different weight ratios (ZnO-T:Me, e...
February 1, 2017: ACS Applied Materials & Interfaces
Ameya P Nayate, James E Schmitt, Suyash Mohan, Ilya M Nasrallah
RATIONALE AND OBJECTIVES: Fluoroscopy-guided lumbar puncture (FGLP) is an operator-dependent procedure that can contribute to lifetime cumulative radiation dose. Benchmark fluoroscopic times (FTs) have been published for ranges of body mass index (BMI), but trends in FT in FGLPs performed by neuroradiology trainees during their training have not been studied. The purpose of this study was to investigate the trends in FTs in FGLPs performed by neuroradiology fellows in an academic year...
January 16, 2017: Academic Radiology
Wei-Zhen Li, Jin-Xun Liu, Jun Gu, Wu Zhou, Si-Yu Yao, Rui Si, Yu Guo, Hai-Yan Su, Chun-Hua Yan, Wei-Xue Li, Ya-Wen Zhang, Ding Ma
Ruthenium is a promising low-temperature catalyst for Fischer-Tropsch synthesis (FTS). However, its scarcity and modest specific activity limit its widespread industrialization. We demonstrate here a strategy for tuning the crystal phase of catalysts to expose denser and active sites for a higher mass-specific activity. Density functional theory calculations show that upon CO dissociation there are a number of open facets with modest barrier available on the face-centered cubic (fcc) Ru but only a few step edges with a lower barrier on conventional hexagonal-closest packed (hcp) Ru...
February 2, 2017: Journal of the American Chemical Society
Qing Dong, Kai Zhang, Shouqiang Cao, Jian Cui
BACKGROUND: The aim of this study is to investigate the effects of fast-track surgery (FTS) on postoperative recovery, hospital stay, total medical costs, and the complications of pneumonectomy in patients with non-small cell lung cancer (NSCLC). METHODS: Studies were performed between June 2012 and March 2014 in 17 patients received FTS and 18 patients given conventional management (control) after pneumonectomy in the Department of Thoracic Surgery, the Fourth Affiliated Hospital of Harbin Medical University...
January 13, 2017: World Journal of Surgical Oncology
Zhenguo Sun, Xiquan Ke, Steven L Salzberg, Daehwan Kim, Valentin Antonescu, Yulan Cheng, Binbin Huang, Jee Hoon Song, John M Abraham, Sariat Ibrahim, Hui Tian, Stephen J Meltzer
BACKGROUND: Novel fusion transcripts (FTs) caused by chromosomal rearrangement are common factors in the development of cancers. In the current study, the authors used massively parallel RNA sequencing to identify new FTs in colon cancers. METHODS: RNA sequencing (RNA-Seq) and TopHat-Fusion were used to identify new FTs in colon cancers. The authors then investigated whether the novel FT nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 FT (KLHL29FT) was transcribed from a genomic chromosomal rearrangement...
January 12, 2017: Cancer
Jieni Xu, Xiaolan Zhang, Yichao Chen, Yixian Huang, Pengcheng Wang, Yuan Wei, Xiaochao Ma, Song Li
We have previously improved the bioactivity of PEG5k-FTS2 system by incorporating disulfide bond (PEG5k-S-S-FTS2) to facilitate the release of farnesyl thiosalicylic acid (FTS).1 Later, fluorenylmethyloxycarbonyl (Fmoc) moiety has been introduced to PEG5k-FTS2 system (PEG5k-Fmoc-FTS2) in order to enhance drug loading capacity (DLC) and formulation stability.2 In this study, we have brought in both disulfide linkage and Fmoc group to PEG5k-FTS2 to form a simple PEG5k-Fmoc-S-S-FTS2 micellar system. PEG5k-Fmoc-S-S-FTS2 conjugate formed filamentous micelles with a ∼10-fold decrease in critical micellar concentration (CMC)...
January 3, 2017: Molecular Pharmaceutics
Sandy Gim Ming Ong, Mallikarjun Chitneni, Kah Seng Lee, Long Chiau Ming, Kah Hay Yuen
The aim of the present study was to study the efficiency of different techniques used for nanosizing liposomes. Further, the aim was also to evaluate the effect of process parameters of extrusion techniques used for nanosizing liposomes on the size and size distribution of the resultant liposomes. To compare the efficiency of different nanosizing techniques, the following techniques were used to nanosize the liposomes: extrusion, ultrasonication, freeze-thaw sonication (FTS), sonication and homogenization. The extrusion technique was found to be the most efficient, followed by FTS, ultrasonication, sonication and homogenization...
December 21, 2016: Pharmaceutics
Michael C Grant, Dongjie Yang, Christopher L Wu, Martin A Makary, Elizabeth C Wick
OBJECTIVE: The aim of this study was to establish if enhanced recovery after surgery (ERAS) and fast track surgery (FTS) protocols are associated with reduction in healthcare-associated infection (HAIs). BACKGROUND: Evidence suggests that prevention strategies for HAIs should be multifaceted and transdisciplinary. ERAS and FTS protocols are collaborative approaches to perioperative care which reduce length of stay but may also be an effective strategy for reducing HAIs...
January 2017: Annals of Surgery
Ahmed Mohamed Ashshi
Cytomegalovirus (CMV) has recently been suggested as a potential risk factor for the development of ectopic pregnancy (EP) following upper genital tract infection in women. However, little is known about its associated underlying pathogenic mechanisms. This was a prospective case-control study that measured the prevalence of CMV infection in Fallopian tubes (FT) bearing an EP and its effects on the tubal expression of interleukin (IL)-6 and its signaling molecules, which are known to play significant roles in the immune response against CMV infection as well as embryo implantation...
December 2016: Virusdisease
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