Jingshu Hong, Yue Li, Lei Chen, Dengyang Han, Yitong Li, Xinning Mi, Kaixi Liu, Qian Wang, Yanan Song, Taotao Liu, Ning Yang, Yajie Liu, Zhengqian Li, Xiangyang Guo
Delayed neurocognitive recovery (dNCR) is a common complication in geriatric surgical patients. The impact of anesthesia and surgery on patients with neurodegenerative diseases, such as Parkinson's disease (PD) or prion disease, has not yet been reported. In this study, we aimed to determine the association between a pre-existing A53T genetic background, which involves a PD-related point mutation, and the development of postoperative dNCR. We observed that partial hepatectomy induced hippocampus-dependent cognitive deficits in 5-month-old A53T transgenic mice, a model of early-stage PD without cognitive deficits, unlike in age-matched wild-type (WT) mice...
May 3, 2024: Biochemical Pharmacology