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https://www.readbyqxmd.com/read/29218314/endoscopic-pancreatic-balloon-sphincteroplasty-for-difficult-to-treat-pancreatic-stones-and-strictures-experience-in-80-patients
#1
Rinkesh Kumar Bansal, Gaurav Kumar Patil, Rajesh Puri, Narendra S Choudhary, Saurabh R Patle, Zubin D Sharma, Randhir Sud
Background and aim:  There is paucity of data about endoscopic pancreatic sphincteroplasty (EPS) after endoscopic pancreatic sphincterotomy (EPST) in the treatment of chronic pancreatitis. The aim of this study was to establish the indications for EPS, complications related to it, and to examine its effectiveness in managing chronic pancreatitis after a year of follow-up. Methods:  We evaluated the safety and efficacy of pancreatic balloon dilation coupled with sphincterotomy for the treatment of chronic pancreatitis...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29213027/-autoimmune-pancreatitis-and-igg4-related-hepatic-inflammatory-pseudotumor-complicated-by-an-impacted-pancreatic-stone-at-the-major-papilla-during-steroid-treatment
#2
Kunio Kataoka, Koichi Achiwa
A 79-year-old male presented to our hospital with abdominal discomfort and was diagnosed with mass-forming pancreatitis. During follow-up, pancreatic stones and a hepatic mass with peripheral bile duct dilation were discovered. Serum IgG4 level was elevated, and a liver tumor biopsy revealed numerous IgG4-positive plasma cells and fibrosis. Chronic pancreatitis with the suspected involvement of autoimmune pancreatitis (AIP) and IgG4-related hepatic inflammatory pseudotumor (IgG4-HIP) was diagnosed. Therefore, a steroid treatment was initiated...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29212476/the-role-of-endoscopic-ultrasound-in-children-with-pancreatobiliary-and-gastrointestinal-disorders-a-single-center-series-and-review-of-the-literature
#3
Alessandro Fugazza, Barbara Bizzarri, Federica Gaiani, Marco Manfredi, Alessia Ghiselli, Pellegrino Crafa, Maria Clotilde Carra, Nicola de'Angelis, Gian Luigi de'Angelis
BACKGROUND: The role of endoscopic ultrasound (EUS) in the management of pancreatobiliary and digestive diseases is well established in adults, but it remains limited in children. The aim of this study was to evaluate the feasibility, safety, and clinical impact of EUS use in children. METHODS: This is a retrospective analysis of a prospectively acquired database of consecutive pediatric (< 18 years) patients presenting an indication for EUS for pancreatobiliary and gastrointestinal disorders...
December 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29204517/proteomic-analysis-of-aqp11-null-kidney-proximal-tubular-type-polycystic-kidney-disease
#4
Tatsuya Saito, Yasuko Tanaka, Yoshiyuki Morishita, Kenichi Ishibashi
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by the mutation of polycystins (PC-1 or PC-2), in which cysts start from the collecting duct to extend to all nephron segments with eventual end stage renal failure. The cyst development is attenuated by a vasopressin V2 receptor antagonist tolvaptan which, however, will not affect proximal tubule cysts devoid of V2 receptor. Aquaporin-11 (AQP11) is expressed selectively in the proximal tubule of the kidney and AQP11-null kidneys have a disruptive PC-1 trafficking to the plasma membrane to develop polycystic kidneys...
March 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29201486/gallstone-pancreatitis-a-common-but-often-overlooked-cause-of-abdominal-pain-in-post-liver-transplant-patients
#5
Napatt Kanjanahattakij, Kamolyut Lapumnuaypol, Sanna Fatima, Eyob Feyssa
Introduction: In general population, gallstone pancreatitis is the most common cause of pancreatitis. However, there are very few literatures that address this topic in post-liver-transplant patients. Clinical Case: A 69-year-old female who had a liver transplant in 2015 due to hepatocellular carcinoma and nonalcoholic steatohepatitis (NASH) cirrhosis. She had a recent episode of acute cellular rejection that was treated with high dose methylprednisolone 1 week prior to admission...
2017: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29173301/targeted-gene-next-generation-sequencing-in-chinese-children-with-chronic-pancreatitis-and-acute-recurrent-pancreatitis
#6
Yuan Xiao, Wentao Yuan, Bo Yu, Yan Guo, Xu Xu, Xinqiong Wang, Yi Yu, Yi Yu, Biao Gong, Chundi Xu
OBJECTIVE: To identify causal mutations in certain genes in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). STUDY DESIGN: After patients were enrolled (CP, 55; ARP, 14) and their clinical characteristics were investigated, we performed next-generation sequencing to detect nucleotide variations among the following 10 genes: cationic trypsinogen protease serine 1 (PRSS1), serine protease inhibitor, Kazal type 1 (SPINK1), cystic fibrosis transmembrane conductance regulator gene (CFTR), chymotrypsin C (CTRC), calcium-sensing receptor (CASR), cathepsin B (CTSB), keratin 8 (KRT8), CLAUDIN 2 (CLDN2), carboxypeptidase A1 (CPA1), and ATPase type 8B member 1 (ATP8B1)...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29147123/acute-necrotizing-pancreatitis-following-coronary-artery-angiography-a-case-report
#7
Majid Hajimaghsoudi, Faezeh Zeinali, Mehrdad Mansouri, Mohammad Hosein Dehghani
BACKGROUND: Acute pancreatitis has different etiologies from biliary stone to metabolic disturbances. Coronary angiography is one of the newly understood etiologies. CASE REPORT: This paper is about a women suffering from acute pancreatitis after coronary angiography. CONCLUSION: Embolization of cholesterol crystals due to vessel wall trauma during coronary angiography as well as contrast medium are responsible for such side effect.
May 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29145338/pancreatogenic-choledocholithiasis-in-common-bile-duct-stump-after-roux-en-y-hepaticojejunostomy-a-case-report
#8
Yuan-Hui Jiang, An-Hong Zhang, Shao-Jun Zhou
RATIONALE: Choledocholithiasis in common bile duct (CBD) stump after Roux-en-Y hepaticojejunostomy (RYHJ) is incredibly rare and its pathophysiology is poorly understood. PATIENT CONCERNS: A 79-year-old woman was admitted to our hospital with upper abdominal pain radiating through to the back in November 2016. DIAGNOSES: Abdominal computed tomography (CT) scan and magnetic resonance cholangiopancreatography (MRCP) revealed filling defects in CBD stump, chronic pancreatitis, and dilatation of CBD stump and main pancreatic duct (MPD)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132521/gallbladder-dysfunction-cholecystitis-choledocholithiasis-cholangitis-and-biliary-dyskinesia
#9
REVIEW
Thad Wilkins, Edward Agabin, Jason Varghese, Asif Talukder
The prevalence of gallstones is 10% to 15% in adults. Individuals with acute cholecystitis present with right upper quadrant pain, fever, and leukocytosis. Management includes supportive care and cholecystectomy. The prevalence of choledocholithiasis is 10% to 20%, and serious complications include cholangitis and gallstone pancreatitis. The goal of management in individuals with choledocholithiasis consists of clearing common bile duct stones. Acute ascending cholangitis is a life-threatening condition involving acute inflammation and infection of the common bile duct...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29117728/different-pattern-of-risk-factors-for-post-ercp-pancreatitis-in-patients-with-biliary-stricture
#10
Liang Zheng, Xiangping Wang, Qin Tao, Shuhui Liang, Biaoluo Wang, Hui Luo, Rongchun Zhang, Liyue Zheng, Shengye Yang, Jie Chen, Yanglin Pan, Xuegang Guo
OBJECTIVE: To identify possible risk factors associated with post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in biliary stricture (BS), common bile duct stone (CBDS) and unselected patients. MATERIALS AND METHODS: Consecutive ERCP patients with native papilla from January 2010 to December 2014 in Xijing Hospital were eligible. Patient-related and procedure-related parameters were collected retrospectively. The primary outcome was PEP...
November 9, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29112097/predictive-factors-for-long-operative-duration-in-patients-undergoing-laparoscopic-cholecystectomy-after-endoscopic-retrograde-cholangiography-for-combined-choledochocystolithiasis
#11
Ryukyung Lee, Heontak Ha, Young Seok Han, Min Kyu Jung, Jae Min Chun
PURPOSE: Choledochocystolithiasis and its associated complications such as cholangitis and pancreatitis are managed by endoscopic retrograde cholangiography (ERC), with endoscopic stone extraction followed by laparoscopic cholecystectomy (LC). However, affected patients present with complex conditions linked to operative difficulties in performing LC. The aim of this study was to elucidate the predictive factors for a prolonged LC procedure following ERC for treating patients with choledochocystolithiasis...
November 3, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29096689/rectally-administered-indomethacin-to-prevent-post-eswl-pancreatitis-ripep-study-protocol-for-a-randomized-controlled-trial
#12
Yang-Yang Qian, Hui Chen, Xin-Ying Tang, Xi Jiang, Wei Qian, Wen-Bin Zou, Lei Xin, Bo Li, Yan-Fen Qi, Liang-Hao Hu, Duo-Wu Zou, Zhen-Dong Jin, Dong Wang, Yi-Qi Du, Luo-Wei Wang, Feng Liu, Zhao-Shen Li, Zhuan Liao
BACKGROUND: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is the first-line therapy for large pancreatic duct stones. Although it is a highly effective and safe procedure for the fragmentation of pancreatic stones, it is still not complication-free. Just like endoscopic retrograde cholangiopancreatography (ERCP), pancreatitis is the most common complication. To date, nonsteroidal anti-inflammatory drugs (NSAIDs) have proven to be the only effective prophylactic medication for post-ERCP pancreatitis and the European, American and Japanese Society for Gastrointestinal Endoscopy guidelines have recommended prophylactic rectally administered indomethacin for all patients undergoing ERCP...
November 2, 2017: Trials
https://www.readbyqxmd.com/read/29091592/procalcitonin-and-pancreatic-stone-protein-function-as-biomarkers-in-early-diagnosis-of-pediatric-acute-osteomyelitis
#13
Chunmiao Cui, Muyong Fu, Boqian Gao
BACKGROUND High plasma levels of procalcitonin (PCT) are typically seen in children with severe bacterial infection, particularly in cases of septic shock or bacteremia. Similarly, pancreatic stone protein (PSP) is associated with inflammation, infection, and other disease-related stimuli. However, the prognostic value of PSP in critically ill pediatric patients is unknown. This study investigated the early diagnostic value of PCT and PSP in pediatric acute osteomyelitis. MATERIAL AND METHODS A total of 187 patients with suspected acute osteomyelitis and 80 healthy control children were enrolled...
November 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29090241/multicenter-retrospective-and-comparative-study-of-5-minute-versus-15-second-endoscopic-papillary-balloon-dilation-for-removal-of-bile-duct-stones
#14
Ryunosuke Hakuta, Tsuyoshi Hamada, Yousuke Nakai, Hiroyuki Isayama, Hirofumi Kogure, Suguru Mizuno, Takahara Naminatsu, Hiroshi Yagioka, Osamu Togawa, Saburo Matsubara, Yukiko Ito, Natsuyo Yamamoto, Takeshi Tsujino, Kazuhiko Koike
BACKGROUND AND STUDY AIMS:  Endoscopic papillary balloon dilation (EPBD) is a method of bile duct stone removal that has a better long-term outcome but a high risk of post-ERCP pancreatitis (PEP). Recent studies have suggested that 5-minute EPBD can reduce the incidence of PEP. This study aimed to examine the safety and effectiveness of longer duration EPBD compared with shorter duration EPBD (5 minutes vs. 15 seconds after disappearance of the waist of a dilation catheter). PATIENTS AND METHODS:  Patients without a history of endoscopic sphincterotomy or EPBD who underwent EPBD to remove bile duct stones were selected retrospectively from five centers...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29069604/duct-and-acinar-derived-pancreatic-ductal-adenocarcinomas-show-distinct-tumor-progression-and-marker-expression
#15
Rute M M Ferreira, Rocio Sancho, Hendrik A Messal, Emma Nye, Bradley Spencer-Dene, Richard K Stone, Gordon Stamp, Ian Rosewell, Alberto Quaglia, Axel Behrens
The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophysiology and marker expression dependent on cell of origin. Whereas acinar-derived tumors exhibited low AGR2 expression and were preceded by pancreatic intraepithelial neoplasias (PanINs), duct-derived tumors displayed high AGR2 and developed independently of a PanIN stage via non-mucinous lesions...
October 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/29062619/choledocholithiasis-treatment-options-in-a-tertiary-care-setup-in-pakistan
#16
Ramlah Ghazanfor, Naeem Liaqat, Mehwish Changeez, Maham Tariq, Sara Malik, Khawaja R Ghazanfar, Jahangir S Khan
Introduction Among patients with cholelithiasis, choledocholithiasis may also be present in about 18% of cases. They can be treated through various endoscopic, laparoscopic, and open surgical procedures. Objective The objective of this study was to determine the outcome of patients with choledocholithiasis being treated in our setup. Methods This descriptive case series was conducted at Holy Family Hospital, Rawalpindi, Pakistan over two years from January 2015 to December 2016. All patients with choledocholithiasis admitted to Surgical Unit 1 were included in this study...
August 21, 2017: Curēus
https://www.readbyqxmd.com/read/29043861/nasobiliary-drainage-can-reduce-the-incidence-of-post-ercp-pancreatitis-after-papillary-large-balloon-dilation-plus-endoscopic-biliary-sphincterotomy-a-randomized-controlled-trial
#17
Qiang Huang, Feng Shao, Chen Wang, Wei Qi, Lu Jun Qiu, Zheng Liu
BACKGROUND AND AIMS: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis can be reduced following endoscopic papillary balloon dilation with the placement of an endoscopic nasobiliary drainage (ENBD) catheter. The aim of this study was to determine whether the placement of an ENBD reduces the risk of post-ERCP pancreatitis following endoscopic papillary large balloon dilation together with endoscopic biliary sphincterotomy. METHODS: A total of 160 patients with bile duct stones were randomly assigned (1:1) to an ENBD group or no-ENBD group...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29019098/gallstone-ileus-monocentric-experience-looking-for-the-adequate-approach
#18
Vincenzo Scuderi, Vincenzo Adamo, Marco Naddeo, William Di Natale, Ljevin Boglione, Sebastiano Cavalli
Common complications of biliary lithiasis are cholecystitis, bile duct lithiasis, and acute biliary pancreatitis. Gallstone ileus is uncommon complications often requiring surgical approach. It is a mechanical bowel obstruction caused by a biliary calculus usually originating from a bilioenteric fistula. Because of the limited number of reported cases, the optimal surgical method of treatment has been the subject of ongoing debate. A retrospective, observational, descriptive study was conduct on patients diagnosed with non-neoplastic bowel occlusion...
October 10, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28944336/development-of-acute-cholecystitis-following-laparoscopic-partial-cholecystectomy
#19
Oktay Karaköse, Mehmet Zafer Sabuncuoğlu, Mehmet Fatih Benzin, Girayhan Çelik, Mahmut Bülbül, Hüseyin Pülat
In cases where the dissection of Calot's triangle is difficult during laparoscopic cholecystectomy, laparoscopic partial cholecystectomy is an alternative to total cholecystectomy to prevent bile duct damage. However, recurrent symptoms and bile duct problems associated with the remaining gallbladder tissue may develop in patients over time. The case of a 45-year-old male who underwent laparoscopic partial cholecystectomy one year previously is presented here. In the postoperative period, as a result of tests for the continuing symptoms of cholecystitis, stones and surrounding abscess were detected in the remaining gallbladder tissue, so open completion cholecystectomy was applied...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/28944138/surgical-treatments-for-patients-with-recurrent-bile-duct-stones-and-oddis-sphincter-laxity
#20
REVIEW
Boxuan Zhou, Jinxiong Hu, Yuesi Zhong
Recurrent bile duct stones is the most common complication after gallstone surgery and the incidence is about 4-24%. Sphincter of Oddi laxity will lead to duodenal content flow into the bile or pancreatic duct. Patients with recurrent bile duct stones and Oddis sphincter laxity were intractable. Here we sought to present the possible and helpful surgical treatments for such patients. Prospective randomized clinical trial are needed for evaluating the outcome of surgical treatments.
August 2017: Intractable & Rare Diseases Research
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