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Rasoul Vafazadeh, Mansoor Namazian, Behnoosh Shahpoori-Arani, Anthony C Willis, Paul D Carr
The mononuclear Ni(II) complexes [Ni(en)2(H2O)2](MAA)2 (1) and [Ni(pn)2(MAA)2] (2), where MAA, en and pn are methacrylate, ethylendiamine and 1,3-propylendiamine, respectively, have been synthesized and characterized by elemental analysis, FT-IR and UV�Vis spectroskopy. Structures of the complexes have been determined by single-crystal X-ray diffraction analyses. In the nickel(II) complexes 1 and 2 nickel(II) ion is six-coordinate and has a distorted octahedral geometry. Ni(II) is bonded to four nitrogen atoms of the two diamines and additionally to two oxygen atoms of aqua ligand in 1, and two oxygen atoms of methacrylate ligands in 2...
June 2018: Acta Chimica Slovenica
Monia Chebbi, Youssef Arfaoui
The N-alkylation reaction of pyrazole derivatives with halomethanes was studied using density functional theory (DFT). The hybrid method B3LYP was employed, along with an ECP basis set such as LANL2DZ for halogen atoms (X = Cl, Br, I) and the 6-311 + G(d,p) basis set for all other atoms. In order to predict the specific site at which the pyrazole derivatives interact with halomethanes, local reactivity descriptors such as the Fukui functions were calculated. Detailed analysis of transition-state energies showed that alkylation occurred at the nitrogen atom N2 in the pyrazole derivatives, in agreement with the chemical reactivity results...
July 9, 2018: Journal of Molecular Modeling
Alice Vianello, Elisa Vencato, Maurizio Cantini, Giovanni Zanconato, Erminia Manfrin, Alberto Zamo, Francesco Zorzi, Filippo Mazzi, Nicola Martinelli, Elena Cavaliere, Francesca Monari, Donatella Venturelli, Francesca Ferrara, Oliviero Olivieri, Lucia De Franceschi
BACKGROUND: The desire for pregnancy in sickle cell disease (SCD) women has become a true challenge for hematologists, requiring a multidisciplinary approach. Erythrocytapheresis (ECP) is an important therapeutic tool in SCD, but only limited data on starting time and the effects of ECP during pregnancy are available. STUDY DESIGN AND METHODS: This is a double-center retrospective cross-sectional study on a total of 46 single pregnancies in SCD women from January 2008 to June 2017...
July 8, 2018: Transfusion
William R Miranda, Darrell B Newman, Lawrence J Sinak, Raul E Espinosa, Nandan S Anavekar, Kashish Goel, Jae K Oh
Aims: To review 2D and Doppler findings in patients diagnosed with effusive-constrictive pericarditis (ECP) and compare these to patients with cardiac tamponade and patients with surgically-proven constrictive pericarditis (CP). Methods and results: We identified 22 patients diagnosed with ECP at Mayo Clinic, MN, USA between 2002 and 2016 who had persistent elevation of jugular venous pressure post-pericardiocentesis. We compared them to 30 patients with CP and 30 patients with cardiac tamponade who had normalization of venous pressure post-pericardiocentesis...
July 5, 2018: European Heart Journal Cardiovascular Imaging
Jocelyn S Gandelman, D Joanne Song, Heidi Chen, Brian G Engelhardt, Yi-Bin Chen, William B Clark, Cynthia R Giver, Edmund K Waller, Dae Kwang Jung, Madan Jagasia
Extracorporeal Photopheresis (ECP) is an accepted treatment for chronic-graft-versus-host disease (cGVHD), however, the mechanism of action is unclear. We conducted a prospective multicenter clinical trial to assess ECP response rates using the 2005 NIH consensus criteria, as well as the relationship between regulatory T cells (Tregs) and treatment response (NCT01324908). 83 patients with any NIH subtype of cGVHD were enrolled, irrespective of number of prior lines of treatment, and 6 were subsequently excluded due to of absence of follow-up from cancer relapse, infection or study withdrawal...
July 5, 2018: Biology of Blood and Marrow Transplantation
Andrey M Kuznetsov, Alexey N Masliy, Gregory V Korshin
Thermodynamic and structural aspects of the hydration of Pb(II) ions were explored based on DFT calculations combined with the supermolecular/continuum solvent model. Hydration of Pb(II) was considered as the formation of Pb(H2 O)n 2+ aqua complexes (n=6-9) from the gas phase Pb(II) ion. Hexa- and hepta-aqua Pb(II) complexes were shown to exhibit the hemidirected symmetry, while those containing eight and nine water molecules are characterized by the holodirected symmetry. The calculations showed that because Pb(H2 O)n 2+ complexes with six to nine water molecules have comparable thermodynamic stabilities, such complexes are likely to coexist in aqueous solutions...
July 4, 2018: Journal of Molecular Modeling
S A Soto-Rodriguez, R Lozano-Olvera, M T Garcia-Gasca, S M Abad-Rosales, B Gomez-Gil, J Ayala-Arellano
Aeromonas dhakensis (Ad) CAIM 1873 growth was evaluated at different conditions and antibiotic susceptibility. Mortality and histopathological damages in hybrid tilapia Oreochromis niloticus × O. mossambicus, and virulence factors caused by Ad bacterial cells and extracellular products (ECPs) were evaluated, and the whole genome was obtained. Ad grew between 0.0 and 5.5% NaCl at a pH of between 4 and 10 and from 4 to 37°C. The lowest minimum inhibitory concentration was found for enrofloxacin (<5 µg ml-1), and bacteria were resistant to erythromycin, amoxicillin and ampicillin...
July 4, 2018: Diseases of Aquatic Organisms
Peida Zhan, Wen-Chung Wang, Hong Jiao, Yufang Bian
Existing cognitive diagnosis models conceptualize attribute mastery status discretely as either mastery or non-mastery. This study proposes a different conceptualization of attribute mastery as a probabilistic concept, i.e., the probability of mastering a specific attribute for a person, and developing a probabilistic-input, noisy conjunctive (PINC) model, in which the probability of mastering an attribute for a person is a parameter to be estimated from data. And a higher-order version of the PINC model is used to consider the associations among attributes...
2018: Frontiers in Psychology
Shinichiro Okamoto, Takanori Teshima, Mizuha Kosugi-Kanaya, Kaoru Kahata, Naomi Kawashima, Jun Kato, Takehiko Mori, Yukiyasu Ozawa, Koichi Miyamura
There are few established therapies for chronic graft-versus-host disease (cGVHD) refractory to first-line treatment with steroids. We evaluated the efficacy and safety of extracorporeal photopheresis (ECP) with a third-generation TC-V device in Japanese patients with cGVHD. Fifteen patients with steroid-resistant or -intolerant cGVHD after allogeneic hematopoietic stem cell transplantation participated in this multicenter open-label study. Extracorporeal photopheresis was conducted on days 1-3, week 1; days 1-2, weeks 2-12; and days 1-2, weeks 16, 20, and 24...
June 29, 2018: International Journal of Hematology
Kimberly W Sanford, Jennifer Anderson, Susan Roseff, Richard A McPherson
Objective: To describe the indicidence and severity of iron deficiency anemia (IDA) in patients who have received extracorporeal photopheresis (ECP) treatment of cutaneous T-cell lymphoma (CTCL). Methods: We performed a retrospective study during a 9-year period of patients with CTCL who were treated with ECP. ECP was performed with UVAR XTS and CELLEX (Therakos Inc). IDA was defined by a drop in hemoglobin (Hb), mean cell volume (MCV), and increased red blood cell distribution width (RDW)...
June 28, 2018: Laboratory Medicine
Elvis Robles-Marín, Alexander Mondragón, Paulina R Martínez-Alanis, Gabriel Aullón, Marcos Flores-Alamo, Ivan Castillo
Iron and molybdenum complexes supported by a pincer-type dianionic [NS2]2- donor were prepared to compare their structural, spectroscopic, and electrochemical properties. The versatility of the [NS2]2Mo(iv) complex (2) to access different oxidation states was evidenced in the activation of methanol and isopropanol, oxidising them to formaldehyde or acetone with concomitant reduction and protonation to afford [NHS2]2Mo(ii), complex (3). This redox behaviour contrasts with the null reactivity observed for the analogous ferric complex [NS2][NHS2]Fe(iii) (1)...
June 28, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Xiaoping Yi, Hang Cao, Haiyun Tang, Guanghui Gong, Zhongliang Hu, Weihua Liao, Lunquan Sun, Bihong T Chen, Xuejun Li
OBJECTIVES: To retrospectively review the radiological and clinicopathological features of gliosarcoma (GSM) and differentiate it from glioblastoma multiforme (GBM). METHODS: The clinicopathological data and imaging findings (including VASARI analysis) of 48 surgically and pathologically confirmed GSM patients (group 1) were reviewed in detail, and were compared with that of other glioblastoma (GBM) cases in our hospital (group 2). RESULTS: There were 28 men and 20 women GSM patients with a median age of 52...
June 12, 2018: European Radiology
Anuradha Narayanan, Shuba Kumar, Krishna Kumar Ramani
Purpose: Compliance to spectacle wear is vital to elimination of avoidable blindness among schoolchildren. This study aims to understand the barriers to compliance and strategies to overcome the barriers from the perspectives of the service providers of the school vision-screening model. Methods: A snapshot qualitative study using focus group discussions (FGDs) was conducted among the service providers including eye care professionals (ECPs) and social workers that are part of the school screening program...
July 2018: Indian Journal of Ophthalmology
Bowen Tian, Bin Zhao, Fei Feng, Fan Luo, Haimei Zhou, Xiaohong Ge, Wu Yanhong, Xinxin Li
In this paper, a novel embeded elliptic cylindrical posts (ECPs) with large surface area and wide effective width, which could support more stationary phase and decrease the pressure drop, is applied on the micro-fabricated gas chromatographic (μGC) column. Compared with μGC column with cylindrical posts (CPs), the surface area and effective width of μGC column with ECPs are increased by 29% and 30%. Separation experiments are performed under the same head pressure at column inlet: in experiments of separating mixture 1, the column efficiency of the μGC column with ECPs for C9 has a 76% improvement, and the separation resolution between C8 and C9 also has a 34% improvement; in experiments of separating mixture 2, seven kinds of analytes can be identified by the μGC column with ECPs less than ten minutes, while, only six kinds can be identified by the μGC column with CPs in almost the same time...
June 20, 2018: Journal of Chromatography. A
Farhad Heshmati
This manuscript highlights a new ANSM (French security agency for food & drug) approved method of ECP in order to render ECP easier and more secure for children and adults, with shorter time of procedure and lower final volume of cells (100 ml) and lower injected 8-MOP. This modified procedure is appropriately called "a Low Volume ECP (LV-ECP)".
June 16, 2018: Transfusion and Apheresis Science
Ramires Alsamir Tibana, Nuno Manuel Frade de Sousa, Gabriel Veloso Cunha, Jonato Prestes, James W Navalta, Fabricio Azevedo Voltarelli
This case report describes an instance of exercise-induced rhabdomyolysis caused by an extreme conditioning program (ECP) competition. A 35-year-old female presented with abdominal pain and soreness, which began one day after she completed two days of ECPcompetition composed of five workouts. Three days after competition, creatine kinase (CK) was 77,590 U/L accompanied by myalgia and abnormal liver function tests, while renal function was normal and this resulted in a diagnosis of rhabdomyolysis. A follow-up examination revealed that her serum level of CK was still elevated to 3034 U/L on day 10 and 1257 U/L on day 25 following the ECP competition...
April 26, 2018: Sports
Jing Ren, Yong Sun, Gang Li, Xiao-Jue Zhu, Jin-Guo Cui
BACKGROUND: Bronchial asthma (BA) is a common chronic respiratory disease that has exhibited a rising global incidence in recent years. Glucocorticoids are used for the treatment of BA. Emerging evidence has demonstrated the roles of tumor necrosis factor (TNF-α), interleukin-8 (IL-8) and eosinophil cationic protein (ECP) in BA. The present study investigated whether TNF-α, IL-8 and ECP were associated with the clinical stages and severity of BA and the efficacy of glucocorticoids in the treatment of BA...
June 13, 2018: Respiratory Physiology & Neurobiology
Maria Maddalena Sirufo, Massimo De Martinis, Lia Ginaldi
RATIONALE: Atopic dermatitis is a frequent, relapsing, chronic inflammatory skin condition with a deep negative impact on quality of life. Three are the major pathological factors driving its complex pathogenesis: the skin barrier disruption, the altered Th2 cell response and itching. Current management of the disease is often unsatisfactory, unable to induce a complete resolution of signs and symptoms or at least a significant clinical improvement with adequate patient satisfaction. PATIENT CONCERNS: We report the case of a 57-year-old man with severe chronic atopic dermatitis for at least 40 years irresponsive to traditional therapies...
June 2018: Medicine (Baltimore)
Lin Lin, Zheng Chen, Xinyue Tang, Fei Dai, Jinjin Wei, Guangbin Sun
BACKGROUND: 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent eosinophil chemoattractant and activator that is synthesized not only in inflammatory cells but also in bronchial epithelial cells. The purpose of this study is to clarify whether 5-oxo-ETE can promote the production of eosinophil cation protein (ECP) by eosinophils in nasal polyps (NP) in vitro, and whether normal nasal epithelial cells can produce this lipid mediator in response to oxidative stress. MATERIALS AND METHODS: Nasal biopsy samples were obtained from normal subjects or subjects with chronic rhinosinusitis with NP...
June 13, 2018: International Archives of Allergy and Immunology
Andrea Matucci, Francesco Liotta, Emanuele Vivarelli, Laura Dies, Francesco Annunziato, Marie Pierre Piccinni, Francesca Nencini, Sara Pratesi, Enrico Maggi, Alessandra Vultaggio
Gleich's syndrome (GS) is characterized by recurrent episodes of angioedema, increase in body weight, fever, hypereosinophilia, and elevated serum IgM. The exact etiology remains unclear. Currently, the only treatment strategy is the administration of high dose of steroids during the acute phases. We report the case of a 37-year-old man suffering from GS with recurrent episodes of angioedema, fever, hypereosinophilia [6,000/mm3 (45%)], and high eosinophil cationic protein (ECP) (>200 μg/l), treated with oral steroids during the acute phase (prednisone 50-75 mg/day), the dose of maintenance being 25 mg/day...
2018: Frontiers in Immunology
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