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https://www.readbyqxmd.com/read/29341484/nasal-ventilation-is-an-important-factor-in-evaluating-the-diagnostic-value-of-nasal-nitric-oxide-in-allergic-rhinitis
#1
Jing Hou, Hongfei Lou, Yang Wang, Fei He, Feifei Cao, Chengshuo Wang, Luo Zhang
BACKGROUND: The role of nasal nitric oxide (NO) in the diagnosis of allergic rhinitis (AR) is controversial. The aim of this study was to identify factors that may affect levels of nasal NO in AR patients and evaluate the role of nasal NO in the diagnosis of AR. METHODS: Seventy-five AR patients and 31 healthy controls were enrolled in this study. AR symptom scores were assessed using the visual analog scale. Eosinophil cationic protein (ECP) was detected by enzyme-linked immunoassay, nasal NO was measured using a chemiluminescence analyzer, and nasal airway resistance (NAR) was assessed by active anterior rhinomanometry...
January 17, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29317198/rhodomyrtone-rom-is-a-membrane-active-compound
#2
Jongkon Saising, Minh Thu Nguyen, Thomas Härtner, Patrick Ebner, Abdulla Al Mamun Bhuyan, Anne Berscheid, Melanie Muehlenkamp, Sina Schäkermann, Nimerta Kumari, Martin E Maier, Supayang P Voravuthikunchai, Julia Bandow, Florian Lang, Heike Brötz-Oesterhelt, Friedrich Götz
Particularly in Asia medicinal plants with antimicrobial activity are used for therapeutic purpose. One such plant-derived antibiotic is rhodomyrtone (Rom) isolated from Rhodomyrtus tomentosa leaves. Rom shows high antibacterial activity against a wide range of Gram-positive bacteria, however, its mode of action is still unclear. Reporter gene assays and proteomic profiling experiments in Bacillus subtilis indicate that Rom does not address classical antibiotic targets like translation, transcription or DNA replication, but acts at the cytoplasmic membrane...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29281699/association-of-flg-single-nucleotide-variations-with-clinical-phenotypes-of-atopic-dermatitis
#3
Myungshin Kim, Jaeeun Yoo, Jiyeon Kim, Joonhong Park, Eunhee Han, Woori Jang, Hyojin Chae, Ji Hyun Lee, Young Min Park, Yonggoo Kim
BACKGROUND: FLG encodes a large protein called profilaggrin, which plays a key role in maintaining an effective skin barrier against the environment. In this study, we identified FLG single nucleotide variations (FLG-SNVs) and evaluated the association of FLG-SNVs with clinical phenotypes including atopic dermatitis (AD)-associated minor clinical features, presence of specific allergic sensitization, and serum parameters. METHODS: Eighty-one Korean patients with AD were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/29255205/associations-between-self-rated-health-sickness-behaviour-and-inflammatory-markers-in-primary-care-patients-with-allergic-asthma-a-longitudinal-study
#4
Karin Lodin, Mats Lekander, Jörgen Syk, Kjell Alving, Anna Andreasson
Allergic asthma is a chronic inflammatory disorder associated with elevated levels of immunoglobulin E (IgE), serum eosinophilic cationic protein (S-ECP), plasma eosinophil-derived neurotoxin (P-EDN) and fraction of exhaled nitric oxide (FENO). Poor self-rated health and sickness behaviour has repeatedly been associated with inflammatory markers, but the nature of this relationship in chronic inflammatory disease is not known. Likewise, such findings largely rely on cross-sectional investigations. Self-rated health (How would you rate your general state of health?), sickness behaviour (mean rating of satisfaction with energy, sleep, fitness, appetite and memory), IgE, S-ECP, P-EDN, and FENO were assessed in 181 non-smoking primary care patients with asthma in a 1-year longitudinal study...
December 18, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29251378/the-physiological-differentiation-along-the-midgut-of-bombyx-mori-inspirations-from-proteomics-and-gene-expression-patterns-of-the-secreted-proteins-in-the-ectoperitrophic-space
#5
L Liu, M Qu, J Yang, Q Yang
The ectoperitrophic space (EcPS) between the insect midgut epithelial cells and the peritrophic matrix is an unexplored, clean resource for concentrated proteins secreted by the midgut epithelial cells, which offers an ideal opportunity to uncover the midgut functions. In this study, we used Bombyx mori as a model organism and performed comparative proteomic analyses of the secreted proteins in the EcPS at the feeding and wandering stages. A total of 372 proteins were identified from both stages and 70 proteins were predicted to be secreted...
December 18, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/29246065/a-new-generation-of-effective-core-potentials-for-correlated-calculations
#6
M Chandler Bennett, Cody A Melton, Abdulgani Annaberdiyev, Guangming Wang, Luke Shulenburger, Lubos Mitas
We outline ideas on desired properties for a new generation of effective core potentials (ECPs) that will allow valence-only calculations to reach the full potential offered by recent advances in many-body wave function methods. The key improvements include consistent use of correlated methods throughout ECP constructions and improved transferability as required for an accurate description of molecular systems over a range of geometries. The guiding principle is the isospectrality of all-electron and ECP Hamiltonians for a subset of valence states...
December 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29232640/decomposition-of-ibuprofen-in-water-via-an-electrochemical-process-with-nano-sized-carbon-black-coated-carbon-cloth-as-oxygen-permeable-cathode-integrated-with-ultrasound
#7
Reza Darvishi Cheshmeh Soltani, Masumeh Mashayekhi
The main aim of the present investigation was the treatment of ibuprofen (IBP)-polluted aquatic phase using a novel oxygen-permeable cathode (OPC)-equipped electrochemical process (ECP) integrated with ultrasound (US). According to kinetic modeling, the decomposition rate of IBP by the integrated process was 3.2 × 10-2 min-1 which was significant in comparison with the OPC-equipped ECP (1.4 × 10-2 min-1) and US alone (2.4 × 10-3 min-1). Increasing the current resulted in the enhanced generation of H2O2 and consequently, improved the degradation of IBP in the solution...
December 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29229196/impact-of-allergy-on-phenotypic-and-endotypic-profiles-of-nasal-polyposis
#8
G Mortuaire, I Gengler, M Balden, M Capron, G Lefèvre
OBJECTIVES: To assess the impact of allergy on clinical presentations (phenotypes) and inflammatory patterns (endotypes) of chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: A single-center prospective study was conducted over an 18-month period. Fifty-seven patients with refractory CRSwNP were included. The diagnosis of allergy was based on concordant skin prick tests and symptoms. Phenotypes were determined on symptom severity score, polyp size classification and Lund-Mackay CT staging...
December 8, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29222315/extracorporeal-photopheresis-cellular-therapy-for-the-treatment-of-acute-and-chronic-graft-versus-host-disease
#9
REVIEW
Jennifer Schneiderman
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative option for many disease states. Despite significant improvements in strategies used to prevent and treat acute and chronic graft-versus-host disease (a/cGVHD), they continue to negatively affect outcomes of HSCT significantly. Standard, first-line treatment consists of corticosteroids; beyond this, there is little consistency in therapeutic regimens. Current options include the addition of various immunosuppressive agents, the use of which puts patients at even higher risks for infection and other morbidities...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29217968/investigation-of-markers-of-allergic-sensitization-and-viral-infections-in-children-with-allergy-and-asthma
#10
Rūta Dubakienė, Vilija Rubinaitė, Malvina Petronytė, Indrė Dalgėdienė, Odilija Rudzevičienė, Dalia Dubakaitė, Palmira Rudalevičienė, Aurelija Žvirblienė
Background: Allergic diseases are the most prevalent chronic diseases in the developed countries. It is believed that early allergic sensitization and respiratory viral infections play an important role in the development of allergic diseases and asthma. Methods: The current study investigated the correlation between asthma, allergy, and various markers - allergen-specific IgE, IgG4 and IgA, ECP, IgM, and IgG antibodies against respiratory viruses hRSV and hPIV1-4 - in blood serum samples from 80 children (mean age 5...
2017: Acta medica Lituanica
https://www.readbyqxmd.com/read/29209850/theoretical-study-of-the-reactions-of-the-hydroselenyl-radical-hse%C3%A2-with-the-selenenic-radical-hseo%C3%A2
#11
Mauricio Angel Vega-Teijido, Martina Kieninger, Oscar N Ventura
The formation of selenium species in some biological processes involves the generation of ionic and radical intermediates such as RSe●, RSe-, RSeO●, and RSeO-, among others. We performed a theoretical study of the possible mechanisms for the reaction of the two simplest Se radicals-the hydroselenyl (HSe●) and selenenic (HSeO●) radicals, in which the possible products, intermediates, and transition-state structures were investigated. Density functional theory (DFT) was applied at the B3LYP/6-311++G(3df,3pd) level and the Ahlrichs Coulomb fitting basis sets were employed with an effective core potential (ECP) for both Se atoms...
December 5, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29200428/low-empathy-like-behaviour-in-male-mice-associates-with-impaired-sociability-emotional-memory-physiological-stress-reactivity-and-variations-in-neurobiological-regulations
#12
Giovanni Laviola, Francesca Zoratto, Danilo Ingiosi, Valentina Carito, Damien Huzard, Marco Fiore, Simone Macrì
Deficits in empathy have been proposed to constitute a hallmark of several psychiatric disturbances like conduct disorder, antisocial and narcissistic personality disorders. Limited sensitivity to punishment, shallow or deficient affect and reduced physiological reactivity to environmental stressors have been often reported to co-occur with limited empathy and contribute to the onset of antisocial phenotypes. Empathy in its simplest form (i.e. emotional contagion) is addressed in preclinical models through the evaluation of the social transmission of emotional states: mice exposed to a painful stimulus display a higher response if in the presence of a familiar individual experiencing a higher degree of discomfort, than in isolation...
2017: PloS One
https://www.readbyqxmd.com/read/29193271/extracorporeal-photopheresis-for-graft-versus-host-disease-identifying-a-clinical-pathway-and-associated-resource-utilization
#13
Swaroopa Yerrabothala, Laleh Talebian, Karen Klinker, Joshua Hickman, John M Hill, Christi Hayes, Christopher Lowrey, Zbigniew M Szczepiorkowski, Kenneth R Meehan
Extracorporeal photopheresis (ECP) is an established therapy for the treatment of graft-versus-host-disease (GVHD) following an allogeneic stem cell transplant. We performed a prospective analysis of patients receiving ECP treatment for GVHD to identify a clinical pathway and resource utilization of this process. The cohort included consecutive allogeneic stem cell recipients with GVHD. ECP was performed using the CELLEX Photopheresis System or the UVAR XTS Photopheresis System (Therakos, Inc, Exton, PA). A clinical pathway was developed and a time and motion study was conducted to define the resource utilization and costs associated with ECP...
November 28, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29192384/spin-states-of-mn-iii-meso-tetraphenylporphyrin-chloride-assessed-by-density-functional-methods
#14
Higo de Lima Bezerra Cavalcanti, Gerd Bruno Rocha
The present work assessed several exchange-correlation functionals (including GGA, meta-GGA and hybrid functionals), in combination with a variety of basis sets and effective core potentials (ECP) for their ability to predict the ground spin state of Mn(III) meso-tetraphenylporphyrin chloride complex, labeled Mn(III)TPPCl, for which experimental data support the quintet high spin state. Geometry optimization of Mn(III)TPPCl was performed for three possible spin states (singlet state, LS; triplet state, IS; and quintet state, HS) at the TPSSh level using the LANL2DZ ECP for Mn and the 6-311G(d) basis set for C, N, Cl and H...
November 30, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29191068/an-exploratory-cost-effectiveness-analysis-of-systemic-treatments-for-cutaneous-t-cell-lymphoma
#15
Larisa Geskin, Daniel C Malone
PURPOSE: To conduct an exploratory cost-effectiveness analysis of systemic treatment options for more advanced cutaneous T-cell lymphoma (CTCL). METHODS: A cost-effectiveness model compared systemic bexarotene, denileukin diftitox, interferon-α, methotrexate, pralatrexate, romidepsin, vorinostat, and extracorporeal photopheresis (ECP) treatment of CTCL. Treatment effectiveness data were extracted from published studies and/or US product labeling. Overall response, the primary effectiveness measure, was defined as the proportion of patients achieving complete or partial response...
December 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29166892/in-vitro-cytotoxic-activity-of-medicinal-plants-from-nigeria-ethnomedicine-on-rhabdomyosarcoma-cancer-cell-line-and-hplc-analysis-of-active-extracts
#16
Omonike O Ogbole, Peter A Segun, Adekunle J Adeniji
BACKGROUND: Cancer is a leading cause of death world-wide, with approximately 17.5 million new cases and 8.7 million cancer related deaths in 2015. The problems of poor selectivity and severe side effects of the available anticancer drugs, have demanded the need for the development of safer and more effective chemotherapeutic agents. The present study was aimed at determining the cytotoxicities of 31 medicinal plants extracts, used in Nigerian ethnomedicine for the treatment of cancer...
November 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29165707/inflammation-dynamics-after-praziquantel-treatment-of-schistosoma-haematobium-reflected-by-urinary-eosinophil-cationic-protein
#17
Chalotte Willemann Stecher, Hassan K M Fofana, Henry Madsen, Shona Wilson, Adama D Keita, Aly Landouré, Mamadou S Traoré, Birgitte J Vennervald, Claus M Reimert, Moussa Sacko
Background: This cohort study assessed urinary eosinophil cationic protein (ECP) as an indicator for urinary tract morbidity and inflammation indication related to single-dose or dual-dose praziquantel (PZQ) treatment. Methods: Urinary ECP was measured at baseline, 24 h and 9 weeks after treatment (baseline 305, follow-up 204 participants, ages 2-40 years). Results: ECP was significantly associated with the intensity of infection at baseline (p<0...
November 20, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29134658/-best-practice-for-extracorporeal-photopheresis-in-acute-and-chronic-graft-versus-host-disease-by-societa-italiana-di-emaferesi-and-manipolazione-cellulare-and-gruppo-italiano-trapianto-midollo-osseo-a-national-survey-to-ascertain-its-degree-of-application
#18
Luca Pierelli, Alberto Bosi, Attilio Olivieri
BACKGROUND: A recent "best practice" promoted and published by Gruppo Italiano Trapianto Midollo Osseo (GITMO) and Societa' Italiana di Emaferesi and Manipolazione Cellulare (SIDEM) on the use of extracorporeal photopheresis (ECP) in acute and chronic graft-versus-host disease (GVHD) has been tested for the degree of agreement and application among Italian transplant centers. STUDY DESIGN AND METHODS: Twenty-four Italian centers coordinating a pair number of transplant programs completed the Web-based survey within the fixed deadline, representing approximately 52% of those centers that have a GITMO-accredited allogeneic transplant program that routinely uses ECP in GVHD...
November 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29124710/ultraviolet-irradiation-of-blood-the-cure-that-time-forgot
#19
Michael R Hamblin
Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However with the development of antibiotics, UBI use declined and it has now been called "the cure that time forgot". Later studies were mostly performed by Russian workers and in other Eastern countries and the modern view in Western countries is that UBI remains highly controversial...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29121973/in-vitro-investigations-on-extracellular-proteins-secreted-by-aphanomyces-invadans-the-causative-agent-of-epizootic-ulcerative-syndrome
#20
Muhammad Majeed, Gokhlesh Kumar, Sarah Schlosser, Mansour El-Matbouli, Mona Saleh
BACKGROUND: Proteases produced by many microorganisms, including oomycetes, are crucial for their growth and development. They may also play a critical role in disease manifestation. Epizootic ulcerative syndrome is one of the most destructive fish diseases known. It is caused by the oomycete Aphanomyces invadans and leads to mass mortalities of cultured and wild fish in many countries. The areas of concern are Australia, China, Japan, South and Southeast Asian countries and the USA. Extracellular proteases produced by this oomycete are believed to trigger EUS pathogenesis in fish...
November 9, 2017: Acta Veterinaria Scandinavica
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