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https://www.readbyqxmd.com/read/28431983/comparison-of-extracorporeal-photopheresis-and-alemtuzumab-for-the-treatment-of-chronic-lung-allograft-dysfunction
#1
Anna Moniodis, Keri Townsend, Alexander Rabin, Obadah Aloum, Jessica Stempel, Patrick Burkett, Phillip Camp, Miguel Divo, Souheil El-Chemaly, Hari Mallidi, Ivan Rosas, Anne Fuhlbrigge, Sophia Koo, Hilary J Goldberg
BACKGROUND: Survival after lung transplantation is limited by chronic lung allograft dysfunction (CLAD). Immunomodulatory therapies such as extracorporeal photopheresis (ECP) and alemtuzumab (AL) have been described for refractory CLAD, but comparative outcomes are not well defined. METHODS: We retrospectively reviewed spirometric values and clinical outcomes after therapy with ECP, AL, or no treatment (NT) in patients with CLAD who underwent transplant between January 2005 and December 2014...
March 24, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28419561/a-transition-from-using-multi-step-procedures-to-a-fully-integrated-system-for-performing-extracorporeal-photopheresis-a-comparison-of-costs-and-efficiencies
#2
Nabih Azar, Veronique Leblond, Maya Ouzegdouh, Paul Button
INTRODUCTION: The Pitié Salpêtrière Hospital Hemobiotherapy Department, Paris, France, has been providing extracorporeal photopheresis (ECP) since November 2011, and started using the Therakos(®) CELLEX(®) fully integrated system in 2012. This report summarizes our single-center experience of transitioning from the use of multi-step ECP procedures to the fully integrated ECP system, considering the capacity and cost implications. MATERIALS AND METHODS: The total number of ECP procedures performed 2011-2015 was derived from department records...
April 17, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28416382/isolation-pathogenicity-and-characterization-of-a-novel-bacterial-pathogen-streptococcus-uberis-from-diseased-mandarin-fish-siniperca-chuatsi
#3
Xia Luo, Xiaozhe Fu, Guoli Liao, Ouqin Chang, Zhibin Huang, Ningqiu Li
In recent years, mandarin fish had a high mortality rate associated with abnormal swimming, exophthalmia, corneal opacity and eye hemorrhage on a fish farm located at Foshan city, Guangdong province, China. Three isolates of Gram-positive, chain-forming cocci were recovered from moribund fish, and designated as SS131025-1, SS131025-2, and SS131025-3. These isolates were identified as Streptococcus uberis according to their morphologic and physio-biochemical characteristics as well as phylogenetic analysis based on their 16S rRNA and GapC gene sequences...
April 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28410721/microbypass-stent-implantation-with-cataract-extraction-and-endocyclophotocoagulation-versus-microbypass-stent-with-cataract-extraction-for-glaucoma
#4
Tanner J Ferguson, Russell Swan, Ramu Sudhagoni, John P Berdahl
PURPOSE: To compare the outcomes of combined microbypass stent implantation, cataract extraction, and endocyclophotocoagulation (ECP) with those of implantation of the same microbypass stent with concomitant cataract surgery in patients with open-angle glaucoma (OAG). SETTING: Private Practice, Sioux Falls, South Dakota, USA. DESIGN: Retrospective consecutive case series. METHODS: Patients from January 2015 to August 2016 were included...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28407513/effects-of-cyanobacteria-synechocystis-spp-in-the-host-parasite-model-crassostrea-gasar-perkinsus-marinus
#5
Fernando Ramos Queiroga, Luis Fernando Marques-Santos, Hélène Hégaret, Roberto Sassi, Natanael Dantas Farias, Lucas Nunes Santana, Patricia Mirella da Silva
Perkinsosis is a disease caused by protozoan parasites from the Perkinsus genus. In Brazil, two species, P. beihaiensis and P. marinus, are frequently found infecting native oysters (Crassostrea gasar and C. rhizophorae) from cultured and wild populations in several states of the Northeast region. The impacts of this disease in bivalves from Brazil, as well as the interactions with environmental factors, are poorly studied. In the present work, we evaluated the in vitro effects of the cyanobacteria Synechocystis spp...
March 27, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28407269/clinical-functional-and-inflammatory-characteristics-in-patients-with-pauci-granulocytic-stable-asthma-comparison-with-different-sputum-phenotypes
#6
Polyxeni Ntontsi, Stelios Loukides, Petros Bakakos, Konstantinos Kostikas, Georgios Papatheodorou, Evgenia Papathanassiou, Georgios Hillas, Nikolaos Koulouris, Spyros Papiris, Andriana I Papaioannou
BACKGROUND: According to induced sputum cell count, four different asthma phenotypes have been recognised(eosinophilic, neutrophilic, mixed and pauci-granulocytic). The aim of the present study was to detect functional and inflammatory characteristics of patients with pauci-granulocytic asthma. METHODS: 240 asthmatic patients were categorised in the four phenotypes according to cell counts in induced sputum. All patients underwent pulmonary function tests, and measurement of FeNO...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28399677/elevated-serum-levels-of-tnf-%C3%AE-il-8-and-ecp-can-be-involved-in-the-development-and-progression-of-bronchial-asthma
#7
Xiao-Gang Jiang, Xu-Dong Yang, Zhe Lv, Peng-Hui Zhuang
OBJECTIVE: This study aimed to explore the value of elevated serum levels of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and eosinophil cationic protein (ECP) in the diagnosis of bronchial asthma (BA). METHODS: Totally 170 patients with BA (case group, 85 patients in acute attack and 85 patients in clinical remission) and 150 healthy individuals (control group). Enzyme-linked immunosorbent assay (ELISA) and receiver operating characteristic (ROC) curves were calculated for the contents and diagnostic values of serum TNF-α, IL-8, and ECP in BA...
April 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28398635/serum-periostin-relates-to-type-2-inflammation-and-lung-function-in-asthma-data-from-the-large-population-based-cohort-swedish-ga-2-len
#8
Anna James, Christer Janson, Andrei Malinovschi, Cecile Holweg, Kjell Alving, Junya Ono, Shoichiro Ohta, Alexandra Ek, Roelinde Middelveld, Barbro Dahlén, Bertil Forsberg, Kenji Izuhara, Sven-Erik Dahlén
BACKGROUND: Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type-2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear. AIM: To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics...
April 11, 2017: Allergy
https://www.readbyqxmd.com/read/28396189/external-counterpulsation-increases-beat-to-beat-heart-rate-variability-in-patients-with-ischemic-stroke
#9
Li Xiong, Ge Tian, Li Wang, Wenhua Lin, Xiangyan Chen, Thomas Wai Hong Leung, Yannie Oi Yan Soo, Lawrence Ka Sing Wong
BACKGROUND AND PURPOSE: External counterpulsation (ECP) is a noninvasive method used to augment cerebral perfusion in ischemic stroke. However, the response of beat-to-beat heart rate variability (HRV) in patients with ischemic stroke during ECP remains unknown. METHODS: Forty-eight patients with unilateral ischemic stroke at the subacute stage and 14 healthy controls were recruited. Beat-to-beat heart rate before, during, and after ECP was monitored. The frequency components of HRV were calculated using power spectral analysis...
April 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28392150/factual-reflections-and-recommendations-on-extracorporeal-photopheresis-in-pediatrics
#10
REVIEW
Irena Sniecinski, Jerard Seghatchian
One of the biggest challenges in evaluating available literature on extracorporeal photopheresis (ECP) practices in pediatric patients is the marked heterogeneity of approaches to the patient evaluation, procedural aspects and apheresis product analysis. These issues are most relevant in ECP management in children with graft versus host disease (GVHD) after hematopoietic stem cell transplantation. Extracorporeal photopheresis in pediatric patients is considered relatively safe with few adverse effects reported from retrospective or observational studies...
March 22, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28391980/histamine-h1-and-h4-receptor-expression-on-the-ocular-surface-of%C3%A2-patients-with-chronic-allergic-conjunctival-diseases
#11
Noriko Inada, Jun Shoji, Yukiko Shiraki, Hiroshi Aso, Satoru Yamagami
BACKGROUND: This study investigated the histamine H1 and H4 receptors mRNA (H1R and H4R, respectively) expression on the ocular surface of patients with chronic forms of allergic conjunctival diseases to determine whether they can serve as biomarkers for allergic inflammation in the conjunctiva. METHODS: We examined 19 patients with vernal or atopic keratoconjunctivitis (AKC/VKC group) and 15 healthy volunteers (control group). The AKC/VKC group was divided into active and stable stage subgroups...
April 5, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28360963/assessing-eosinophilic-cationic-protein-as-a-biomarker-for-monitoring-patients-with-eosinophilic-esophagitis-treated-with-specific-exclusion-diets
#12
Joan Doménech Witek, Vicente Jover Cerdà, Vicente Gil Guillén, Juan Bautista Doménech Clar, Ramón Rodríguez Pacheco
BACKGROUND: Eosinophilic esophagitis (EoE) is a complex pathology. Attempts have been made in order to relate EoE with the intake of certain food. The problem is to establish which foods are really involved in the pathophysiology of this condition and to objectify a reliable inflammation biomarker for the follow-up of patients undergoing pharmacological treatment and/or diets. Our aim is to assess the food sensitization profile of patients with objective diagnosis of EoE and objectify the utility of ECP as an inflammation biomarker for the follow-up of patients with EoE treated with specific diets, based on the hypothesis that we will observe a decrease and clinical improvement after maintenance of these diets...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28359604/extra-corporeal-photochemotherapy-in-steroid-refractory-graft-versus-host-disease-a-review-of-guidelines-and-recommendations
#13
REVIEW
Saeed Mohammadi, Ashraf Malek Mohammadi, Amir Hossein Norooznezhad, Farhad Heshmati, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Regardless of remarkable progresses in prevention and treatment approaches, graft versus host disease (GVHD) remains a major impediment for successful allogeneic hematopoietic stem cells transplantation (HSCT) and leads to morbidity and mortality in transplanted patients. Corticosteroids are the standard therapy for GVHD; however, a great number of patients will not respond sufficiently and others will be significantly affected by adverse effects of steroids. Extracorporeal photochemotherapy (ECP), as one of the numerous second line therapies, through modulation of immune cells may improves GVHD affected organ function in steroid-refractory forms...
February 16, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28352257/a-novel-pan-genome-reverse-vaccinology-approach-employing-a-negative-selection-strategy-for-screening-surface-exposed-antigens-against-leptospirosis
#14
LingBing Zeng, Dongliang Wang, NiYa Hu, Qing Zhu, Kaishen Chen, Ke Dong, Yan Zhang, YuFeng Yao, XiaoKui Guo, Yung-Fu Chang, YongZhang Zhu
Reverse vaccinology (RV) has been widely used for screening of surface-exposed proteins (PSEs) of important pathogens, including outer membrane proteins (OMPs), and extracellular proteins (ECPs) as potential vaccine candidates. In this study, we applied a novel RV negative strategy and a pan-genome analysis for screening of PSEs from 17 L. interrogans strains covering 11 predominately epidemic serovars and 17 multilocus typing (MLST) sequence types (STs) worldwide. Our results showed, for instance, out of a total of 633 predicted PSEs in strain 56601, 92...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28349341/knowledge-and-opinion-of-pharmacists-on-emergency-contraceptive-pills-in-hungary
#15
Melinda Vanya, Maria Matuz, Ria Benko, Reka Viola, Attila Horvath-Sziklai, Gyongyvér Soos, Gyorgy Bartfai
Background Emergency contraceptive pills (ECPs) are used to prevent unintended pregnancy. There is a worldwide intention to improve access to ECPs; therefore, identifying potential barriers to introducing over-the counter (OTC) access is of utmost importance. As pharmacists are the key personnel to convey accurate drug information, their knowledge and attitude on ECPs is important. Objective We aimed to conduct a nationwide study to assess pharmacists' knowledge on ECPs and to survey their opinion on sales category change of ECPs (i...
March 27, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28345056/arctic-sea-ice-eurasia-snow-and-extreme-winter-haze-in-china
#16
Yufei Zou, Yuhang Wang, Yuzhong Zhang, Ja-Ho Koo
The East China Plains (ECP) region experienced the worst haze pollution on record for January in 2013. We show that the unprecedented haze event is due to the extremely poor ventilation conditions, which had not been seen in the preceding three decades. Statistical analysis suggests that the extremely poor ventilation conditions are linked to Arctic sea ice loss in the preceding autumn and extensive boreal snowfall in the earlier winter. We identify the regional circulation mode that leads to extremely poor ventilation over the ECP region...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28338261/extracorporeal-photopheresis-for-the-treatment-of-early-stage-mycosis-fungoides
#17
Daniel J Lewis, Madeleine Duvic
Extracorporeal photopheresis (ECP) has been used for nearly 30 years in the treatment of cutaneous T-cell lymphoma. However, current clinical practice largely reserves ECP for patients with late-stage mycosis fungoides (MF) or Sézary syndrome or for those who are refractory to other therapies. We briefly describe a 48-year-old male who experienced long-term complete remission of his patch MF disease with ECP, and we suggest a role for ECP in the treatment of early-stage MF given evidence of its efficacy, safety, and tolerability...
March 24, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28327742/pair-natural-orbital-and-canonical-coupled-cluster-reaction-enthalpies-involving-light-to-heavy-alkali-and-alkaline-earth-metals-the-importance-of-sub-valence-correlation
#18
Yury Minenkov, Giovanni Bistoni, Christoph Riplinger, Alexander A Auer, Frank Neese, Luigi Cavallo
In this work, we tested canonical and domain based pair natural orbital coupled cluster methods (CCSD(T) and DLPNO-CCSD(T), respectively) for a set of 32 ligand exchange and association/dissociation reaction enthalpies involving ionic complexes of Li, Be, Na, Mg, Ca, Sr, Ba and Pb(ii). Two strategies were investigated: in the former, only valence electrons were included in the correlation treatment, giving rise to the computationally very efficient FC (frozen core) approach; in the latter, all non-ECP electrons were included in the correlation treatment, giving rise to the AE (all electron) approach...
March 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28325114/complexes-of-dna-bases-and-watson-crick-base-pairs-interaction-with-neutral-silver-agn-n-8-10-12-clusters-a-dft-and-tddft-study
#19
Ruby Srivastava
We study the binding of the neutral Agn (n = 8, 10, 12) to the DNA base- adenine (A), guanine (G) and Watson-Crick -adenine-thymine (AT), guanine-cytosine (GC) pairs. Geometries of complexes were optimized at the DFT level using the hybrid B3LYP functional. LANL2DZ effective core potential (ECP) was used for silver and 6-31+G(**) was used for all other atoms. NBO charges were analyzed using the Natural population analysis. The absorption properties of Agn-A,G/WC complexes were also studied using time-dependent density functional theory (TDDFT)...
March 21, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28304115/extracorporeal-photopheresis-in-pediatric-patients-practical-and-technical-considerations
#20
Robert A DeSimone, Joseph Schwartz, Jennifer Schneiderman
In adults, extracorporeal photopheresis (ECP) is widely utilized for a variety of indications, most commonly cutaneous T-cell lymphoma, acute or chronic graft-versus-host disease (GVHD), solid organ transplant rejection, and other autoimmune and T-cell-mediated disorders. In pediatric patients, the majority of case series and reports have focused on its use in the management of acute and chronic GVHD. Currently utilized ECP technologies were designed for adult patients and there are several challenges in adapting these technologies for use in children...
March 17, 2017: Journal of Clinical Apheresis
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