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warfarin pharmacogenomic education

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https://www.readbyqxmd.com/read/27143951/potential-utility-of-precision-medicine-for-older-adults-with-polypharmacy-a-case-series-study
#1
Joseph Finkelstein, Carol Friedman, George Hripcsak, Manuel Cabrera
Pharmacogenomic (PGx) testing has been increasingly used to optimize drug regimens; however, its potential in older adults with polypharmacy has not been systematically studied. In this hypothesis-generating study, we employed a case series design to explore potential utility of PGx testing in older adults with polypharmacy and to highlight barriers in implementing this methodology in routine clinical practice. Three patients with concurrent chronic heart and lung disease aged 74, 78, and 83 years and whose medication regimen comprised 26, 17, and 18 drugs, correspondingly, served as cases for this study...
2016: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/25729462/a-patient-centered-approach-to-the-development-and-pilot-of-a-warfarin-pharmacogenomics-patient-education-tool-for-health-professionals
#2
Megan R Barajas, Christine M Formea, Jennifer B McCormick, Ahmed D Abdalrhim, Leona C Han, Robert D McBane, Alexander S Fiksdal, Iftikhar J Kullo
OBJECTIVE: To describe an exploratory project to develop and pilot a novel patient educational tool that explains the concept of pharmacogenomics and its impact on warfarin dosing that can be utilized by health professionals providing patient counseling. METHODS: A pharmacogenomics educational tool prototype was developed by an interdisciplinary team. During the pilot of the tool, focus group methodology was used to elicit input from patients based upon their perspectives and experiences with warfarin...
March 2015: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/22591350/personalized-medicine-potential-barriers-and-contemporary-issues
#3
REVIEW
Michael J Sorich, Ross A McKinnon
Personalized medicine has gained significant attention over the last decade as technologies for understanding biological differences between individuals have advanced dramatically. There are many potential benefits of personalized medicine including minimizing risk of drug toxicity, increasing benefit from drugs used, contributing to the sustainability of the healthcare system and facilitating drug discovery and development programs. Unfortunately there are also many barriers such as cost, complexity, high quality evidence requirements, and the need for further education that have limited the clinical translation of pharmacogenomic tests to date...
September 1, 2012: Current Drug Metabolism
https://www.readbyqxmd.com/read/21365388/clinical-applications-of-pharmacogenomics-guided-warfarin-dosing
#4
REVIEW
Pramod Mahajan, Kristin S Meyer, Geoffrey C Wall, Heidi J Price
AIM OF THE REVIEW: To assess the state of the literature concerning pharmacogenomic testing in patients requiring vitamin K antagonists, specifically warfarin. METHOD: We conducted a literature search of MEDLINE and International Pharmaceutical Abstracts using the following words: warfarin, pharmacogenetic, and pharmacogenomic. The search results were reviewed by the authors and papers concerning pharmacogenomic testing in warfarin dosing were procured and reviewed...
February 2011: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/21052837/clinical-applications-of-pharmacogenomics-guided-warfarin-dosing
#5
REVIEW
Pramod Mahajan, Kristin S Meyer, Geoffrey C Wall, Heidi J Price
AIM OF THE REVIEW: To assess the state of the literature concerning pharmacogenomic testing in patients requiring vitamin K antagonists, specifically warfarin. METHOD: We conducted a literature search of MEDLINE and International Pharmaceutical Abstracts using the following words: warfarin, pharmacogenetic, and pharmacogenomic. The search results were reviewed by the authors and papers concerning pharmacogenomic testing in warfarin dosing were procured and reviewed...
June 2013: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/20831298/comparative-effectiveness-research-and-personalized-medicine-catalyzing-or-colliding
#6
Robert S Epstein, J Russell Teagarden
Comparative effectiveness research (CER) is generating intense attention as interest grows in finding new and better drug technology assessment processes. The federal government is supporting the expansion of CER through funding made available in the American Recovery and Reinvestment Act of 2009 (ARRA) and by establishing the Patient-Centered Outcomes Research Institute through the Patient Protection and Affordable Care Act of 2010. At the same time, personalized medicine is generating debate about its place in clinical medicine, and so, naturally, how CER can or cannot play a role in personalized medicine is part of these debates...
2010: PharmacoEconomics
https://www.readbyqxmd.com/read/20368146/pharmacogenomics-bridging-the-gap-between-science-and-practice
#7
REVIEW
Kelly C Lee, Joseph D Ma, Grace M Kuo
OBJECTIVE: To educate pharmacists about principles and concepts in pharmacogenomics, clinical applications of pharmacogenomic information, and the social, ethical, and legal aspects of pharmacogenomics and to describe a Centers for Disease Control and Prevention (CDC)-supported pharmacogenomics education program for pharmacists and other health professionals. DATA SOURCES: Primary literature from PubMed, recommendations from the Food and Drug Administration and Evaluation of Genomic Applications in Practice and Prevention Working Group, prescribing information, websites of government agencies and professional organizations, and relevant textbooks...
January 2010: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/19544663/evolution-of-pharmacogenomics
#8
REVIEW
Andrew Somogy
Pharmacogenetics dates back more than 2,000 years to observations by Pythagoras, however it was not until the 1950s when some enzyme polymorphisms (e.g., N-acetyltransferase, G6PD) were discovered that the term was coined by Vogel. Pharmacogenetics then went into decline as being too esoteric a subject. In the 1970s the discovery of the CYP2D6 polymorphism and its resultant effect on drug toxicity and response led to many observations of pharmacogenetic-based variations in pharmacokinetics. These and other discoveries and the subsequent ability to genotype led to the term pharmacogenomics...
2008: Proceedings of the Western Pharmacology Society
https://www.readbyqxmd.com/read/18424351/pharmacogenetics-in-critical-care-atrial-fibrillation-as-an-exemplar
#9
REVIEW
Cynthia A Prows, Theresa A Beery
Pharmacogenetic testing is currently not routine in critical care settings but recent changes in the warfarin label are likely to lead to critical care nurses encountering physician or nurse practitioner orders for such testing. Although the science for pharmacogenetics is complex, the components of patient teaching are not beyond that which nurses already provide about other laboratory, disease, and treatment-based information. It is reasonable to expect that as the science of pharmacogenetics and pharmacogenomics expands and discoveries are translated in clinical settings, the additional information from pharmacogenetic test results will help prescribers select or adjust medication doses to reduce the risk for adverse drug reactions and improve the chances of achieving therapeutic targets in a timely fashion...
June 2008: Critical Care Nursing Clinics of North America
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