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https://www.readbyqxmd.com/read/28078443/double-stenting-with-silicone-and-metallic-stents-for-malignant-airway-stenosis
#1
Keitaro Matsumoto, Naoya Yamasaki, Tomoshi Tsuchiya, Takuro Miyazaki, Ryotaro Kamohara, Go Hatachi, Takeshi Nagayasu
For severe malignant airway stenosis, there are several types of commercially available airway stents, and each has its own advantages and disadvantages. We herein describe the safety and efficacy of combination stenting with silicone and metallic stents for patients with extended malignant airway stenosis. Seven patients with malignant airway stenosis were treated via combination stenting with a silicone stent and a metallic stent for extended airway stenosis from the central to peripheral airways. Five patients were diagnosed with advanced esophageal cancer, two of whom had tracheoesophageal fistulas...
January 11, 2017: Surgery Today
https://www.readbyqxmd.com/read/28070470/assessing-the-need-for-adjuvant-chemotherapy-after-stereotactic-body-radiation-therapy-in-early-stage-non-small-cell-lung-carcinoma
#2
Raphaël Jumeau, Houda Bahig, Édith Filion, Marie-Pierre Campeau, Louise Lambert, David Roberge, Andrei-Bogdan Gorgos, Toni Vu
PURPOSE: Surgery remains the standard treatment for medically operable patients with early-stage non-small cell lung carcinoma (NSCLC). Following surgical resection, adjuvant chemotherapy is recommended for large tumors >4 cm. For unfit patients, stereotactic body radiation therapy (SBRT) has emerged as an excellent alternative to surgery. This study aims to assess patterns of recurrence and discuss the role of chemotherapy after SBRT for NSCLC. METHODS: We reviewed patients treated with SBRT for primary early-stage NSCLC between 2009 and 2015...
November 29, 2016: Curēus
https://www.readbyqxmd.com/read/28057967/massive-thymoma-of-the-mid-posterior-mediastinum-an-unprecedented-case-in-a-young-adult
#3
Karen Fernandes de Oliveira, Marcio Maciel Rodrigues, Gesner Pereira Lopes, Renan Sandoval de Almeida, Juliana Lopes Lusvarghi, João Paulo Vieira Dos Santos
We report an unprecedented case of ectopic thymoma in a young adult. A 33-year-old male presented with a 10-day history of non-productive cough and fever. Investigation revealed mediastinal widening without pulmonary involvement. Computed tomography showed a large mass-14.8 × 10.8 × 8.4 cm-in the mid-posterior mediastinum, and a biopsy obtained by video-assisted thoracoscopy indicated that the mass was a tumor. Immunohistochemistry showed combined thymoma type AB1. Because of the considerable proportions of the tumor and its close proximity to major structures, the patient was treated with chemotherapy...
November 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/28054283/mediastinal-seminoma-associated-with-multilocular-thymic-cyst
#4
Masato Inui, Jun-Ichi Nitadori, Shogo Tajima, Takahusa Yoshioka, Noriko Hiyama, Takeyuki Watadani, Aya Shinozaki-Ushiku, Kazuhiro Nagayama, Masaki Anraku, Masaaki Sato, Masashi Fukayama, Jun Nakajima
An asymptomatic 26-year-old man received an annual medical check-up, and chest X-ray showed a protrusion of the aortopulmonary window. Chest computed tomography (CT) revealed an anterior mediastinal tumor and cysts with thin wall and septum enhancement. The preoperative diagnosis was cystic thymoma or malignant lymphoma. We performed total resection of the tumor through a median sternotomy. The pathological findings revealed seminoma, positive for c-kit stain, and multilocular thymic cysts. Cysts were lined by normal squamous epithelium and no seminoma cells were located on their surface...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28053696/invasive-thymoma-with-pure-red-cell-aplasia-and-amegakaryocytic-thrombocytopenia
#5
Takuya Onuki, Yusuke Kiyoki, Sho Ueda, Masatoshi Yamaoka, Seiich Shimizu, Masaharu Inagaki
We here describe a case involving a 67-yearold female patient who was referred to our hospital due to severe anemia (hemoglobin, 5.0 g/dL), thrombocytopenia (platelet count, 0.6 × 10(4)/μL), and a mediastinal shadow with calcification noted on X-ray. On admission, an anterior mediastinal tumor was detected, and bone marrow biopsy revealed few megakaryocytes and severely reduced numbers of erythroid cells. The diagnosis was thymoma with pure red cell aplasia (PRCA) and acquired amegakaryocytic thrombocytopenia (AAMT)...
November 2, 2016: Hematology Reports
https://www.readbyqxmd.com/read/28048184/su-f-j-95-impact-of-shape-complexity-on-the-accuracy-of-gradient-based-pet-volume-delineation
#6
M Dance, G Wu, Y Gao, S Pirozzi, A Nelson, S Das, J Lian
PURPOSE: Explore correlation of tumor complexity shape with PET target volume accuracy when delineated with gradient-based segmentation tool. METHODS: A total of 24 clinically realistic digital PET Monte Carlo (MC) phantoms of NSCLC were used in the study. The phantom simulated 29 thoracic lesions (lung primary and mediastinal lymph nodes) of varying size, shape, location, and (18) F-FDG activity. A program was developed to calculate a curvature vector along the outline and the standard deviation of this vector was used as a metric to quantify a shape's "complexity score"...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046973/su-f-r-14-pet-based-radiomics-to-predict-outcomes-in-patients-with-hodgkin-lymphoma
#7
J Lee, M Aristophanous, M Akhtari, S Milgrom, D Bouthaina, C Pinnix, S Narang, A Rao, L Court, G Smith
PURPOSE: To identify PET-based radiomics features associated with high refractory/relapsed disease risk for Hodgkin lymphoma patients. METHODS: A total of 251 Hodgkin lymphoma patients including 19 primary refractory and 9 relapsed patients were investigated. All patients underwent an initial pre-treatment diagnostic FDG PET/CT scan. All cancerous lymph node regions (ROIs) were delineated by an experienced physician based on thresholding each volume of disease in the anatomical regions to SUV>2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044001/resection-of-giant-mediastinal-liposarcoma-via-%C3%A2-shape-incision
#8
Wei Huang, Ge Ning Jiang
Primary mediastinal liposarcomas are extremely rare conditions often resected through standard median sternotomy or lateral thoracotomy. However, the management of a very huge mediastinal tumor involving hemithorax through these two common surgical approaches is always challenging. Herein, we report a case of applying median sternotomy with a sternum transection plus a right fourth intercostal thoracotomy ('⊣ shape' incision) to resect a giant primary anterior mediastinal liposarcoma extending into the whole right thorax...
January 2, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28039533/western-strategy-for-egj-carcinoma
#9
Simone Giacopuzzi, Maria Bencivenga, Jacopo Weindelmayer, Giuseppe Verlato, Giovanni de Manzoni
In this paper, the epidemiological and clinicobiological behavior of esophagogastric junction (EGJ) adenocarcinoma in the West is compared and contrasted to that in the East, and an overview is provided of current therapeutic strategies employed for this type of tumor in Western countries. It is well known that multimodal treatment is the therapeutic standard in locally advanced EGJ adenocarcinoma, but whether neoadjuvant/perioperative chemotherapy (CT) or neoadjuvant chemoradiotherapy (CRT) is the optimal approach is still debated...
December 30, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/28033203/outcomes-of-extracorporeal-life-support-during-surgery-for-the-critical-airway-stenosis
#10
Seon Hee Kim, Seunghwan Song, Yeong Dae Kim, Hoseok I, Jeong Su Cho, Hyo Yeong Ahn, Jonggeun Lee, Do Hyung Kim, Bong Soo Son
Anesthetic management of critical airway stenosis is often very challenging. Extracorporeal membrane oxygenation (ECMO) may provide adequate respiratory support when conventional approaches fail. We report our experience of ECMO support for critical airway surgery. Between April 2012 and March 2015, nine patients underwent ECMO-supported airway operation. The reason for surgery was tracheal stenosis in nine patients, and tracheomalacia, tracheal tumor, and external tracheal compression by mediastinal mass in one patient each...
January 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28033154/malignant-melanoma-in-association-with-a-thymic-nevus-in-a-patient-with-a-giant-congenital-nevus
#11
Yulia Shvartser-Beryozkin, Alexander Yakobson, Daniel Benharroch, Milton Saute, Meora Feinmesser
Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28029320/pulmonary-infiltrates-in-a-patient-with-advanced-melanoma
#12
Charles A Powell
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28025474/mediastinal-tuberculous-lymphadenitis-diagnosed-by-endosonographic-fine-needle-aspiration
#13
Joonhwan Kim, Youngwoo Jang, Kyung Oh Kim, Yoon Jae Kim, Dong Kyun Park, Dong Hae Chung, Eun Young Kim, Jun Won Chung
Isolated mediastinal tuberculous lymphadenitis is clinically rare. Its clinical presentation may mimic an esophageal submucosal tumor by extrinsic compression. A 26-year-old woman was referred to our hospital for an esophageal subepithelial tumor. A 15×10 mm sized subepithelial lesion was found 30 cm from the upper incisors on esophagogastroduodenoscopy. We diagnosed the lesion as a submucosal tumor, and performed endoscopic ultrasonography-guided fine needle aspiration for a pathologic diagnosis. The histologic examination revealed granulomatous inflammation consistent with tuberculosis...
December 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28008897/-surgical-treatment-of-thyroid-cancer-metastases-in-the-7th-retrosternal-group-of-lymph-nodes
#14
I V Reshetov, A K Golubtsov, F E Sevryukov, A A Shevalgin
: The incidence of thyroid cancer (TC) is being significantly increased. A significant percentage consists of metastatic cancer (MCP) in particular in the anterior-superior mediastinal lymph nodes (Group 7). MATERIAL AND METHODS: 153 out of 324 patients with metastatic TC underwent video-assisted lymphadenectomy of group 7 of lymph nodes. The operations were combined with interventions on the primary tumor or on cervical lymph nodes in case of recurrence. RESULTS: The possibility of long-term survival (over 10 years) was studied in more than 80% of cases...
2016: Khirurgiia
https://www.readbyqxmd.com/read/28007263/thymic-and-mediastinal-lymph-node-metastasis-of-colon-cancer
#15
Yoko Yamamoto, Ken Kodama, Yoshihito Ide, Masashi Takeda
Most anterior mediastinal tumors are thymomas. Thymic metastasis from other primary cancers is extremely rare. We report the case of a 72-year-old man who developed thymic and mediastinal lymph node metastases of cecum cancer. He had undergone laparoscopic ileocecal resection with regional lymph node dissection for primary cecum cancer 15 months previously. Follow-up computed tomography revealed tumors in the anterior mediastinum. Fluorodeoxyglucose positron emission tomography showed positive uptake in the tumors...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28003760/comparison-of-the-clinical-features-and-hematopoietic-stem-cell-transplantation-outcomes-of-mediastinal-malignant-germ-cell-tumors-with-nonmediastinal-extragonadal-placements
#16
Nesrin Ocal, Birol Yildiz, Nuri Karadurmus, Deniz Dogan, Sukru Ozaydin, Ramazan Ocal, Mustafa Ozturk, Fikret Arpaci, Hayati Bilgic
OBJECTIVE: Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantation between mediastinal and nonmediastinal malignant EGCTs. METHOD: Data of the patients with EGCT who were treated and underwent hematopoietic stem cell transplantation at our hospital between 1988 and 2015 were retrieved retrospectively...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27994685/intra-patient-variability-of-fdg-standardized-uptake-values-in-mediastinal-blood-pool-liver-and-myocardium-during-r-chop-chemotherapy-in-patients-with-diffuse-large-b-cell-lymphoma
#17
Soo Jeong Kim, Hyun Kyung Yi, Chae Hong Lim, Young Seok Cho, Joon Young Choi, Yearn Seong Choe, Kyung-Han Lee, Byung-Tae Kim, Seung Hwan Moon
PURPOSE: (18)F-fluorodeoxyglucose (FDG) PET/CT is useful for staging and evaluating treatment response in patients with diffuse large B-cell lymphoma (DLBCL). A five-point scale model using the mediastinal blood pool (MBP) and liver as references is a recommended method for interpreting treatment response. We evaluated the variability in standardized uptake values (SUVs) of the MBP, liver, and myocardium during chemotherapy in patients with DLBCL. METHODS: We analyzed 60 patients with DLBCL who received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) treatment and underwent baseline, interim, and final FDG PET/CT scans...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27993806/impact-of-primary-metastatic-bone-disease-in-germ-cell-tumors-results-of-an-international-global-germ-cell-tumor-collaborative-group-g3-registry-study
#18
C Oing, K Oechsle, A Necchi, Y Loriot, U De Giorgi, A Fléchon, G Daugaard, M Fedyanin, E Faré, C Bokemeyer
BACKGROUND: Bone metastases (BM) are rare in germ cell tumor (GCT) patients. Systematic data on risk factors, treatment and outcome are largely lacking. PATIENTS AND METHODS: A database created by an international consortium including 123 GCT patients with BM at primary diagnosis was retrospectively analyzed. Survival estimates were calculated by the method of Kaplan-Meier and compared by log-rank testing. Cox regression analysis was applied for risk factor analyses...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27991022/-minimal-invasive-esophageal-resection-with-anastomosis-on-the-neck-mckeown-our-experiences-after-20-cases
#19
Elemér Mohos, Attila Nagy, György Szabados, György Réti, Tamás Kovács, Zoltán Jánó, Csaba Berki, József Mohay, Lóránt Szabó, Krisztina Bene, Gábor Bognár, Myroslav Horzov, Petra Mohos, Gábor Sándor, Gábor Tornai, Péter Szenkovits, Tibor Nagy, Csaba Orbán, Vivien Herpai
OBJECTIVE: Esophageal resection is a traumatic intervention usually performed on patients with poor condition, resulting high mortality and morbidity. To improve the high incidence of complications, minimal invasive interventions were introduced. The results of the thoracoscopically and laparoscopically performed esophageal resection (McKeown) was investigated after 20 cases and the technical details of the surgical intervention are presented. PATIENTS AND METHOD: 20 thoracoscopic esophageal resection with laparoscopic gastric tube formation (sec...
December 2016: Magyar Sebészet
https://www.readbyqxmd.com/read/27974110/-clinical-features-and-outcomes-of-neuroblastoma-patients-aged-above-5-years
#20
Yi Zhang, Wei-Ling Zhang, Dong-Sheng Huang, Tao Han, Tian Zhi, Jing Li, You Yi, Yuan Wen, Fan Li, Yan-Yan Mei, Yan-Yan DU
OBJECTIVE: To investigate the clinical features and outcomes of neuroblastoma (NB) children aged above 5 years, and to provide a theoretical basis for improving prognosis. METHODS: A retrospective analysis was performed for the clinical data of 54 previously untreated NB children, and their clinical features and outcome were analyzed. The Kaplan-Meier method was used for survival analysis. RESULTS: Among the 54 children, there were 36 boys and 18 girls, and all of them had stage 3 or 4 NB...
December 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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