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Heart failure biomarkers

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https://www.readbyqxmd.com/read/28340049/cardiac-troponin-i-as-a-predictor-of-mortality-in-patients-with-first-episode-acute-atrial-fibrillation
#1
Mohammad E Naffaa, Roni Nasser, Elias Manassa, Maha Younis, Zaher S Azzam, Doron Aronson
Background: Recent-onset atrial fibrillation (AF) is a frequent cause for presentation to the emergency department. Recent studies proposed that the addition of biomarker information might improve the prediction of clinical outcomes by enabling identification of patients at high risk. Aim: We aimed to examine the role of cardiac troponin I as a predictor of clinical outcome in patients with first episode acute atrial fibrillation. Design: : Patients, 18 years or older, presenting to our hospital with a primary diagnosis of first episode acute atrial fibrillation were included in this retrospective study...
March 11, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28339818/refining-success-of-cardiac-resynchronization-therapy-using-a-simple-score-predicting-the-amount-of-reverse-ventricular-remodelling-results-from-the-markers-and-response-to-crt-marc-study
#2
Alexander H Maass, Kevin Vernooy, Sofieke C Wijers, Jetske van 't Sant, Maarten J Cramer, Mathias Meine, Cornelis P Allaart, Frederik J De Lange, Frits W Prinzen, Bart Gerritse, Erna Erdtsieck, Coert O S Scheerder, Michael R S Hill, Marcoen Scholten, Mariëlle Kloosterman, Iris A H Ter Horst, Adriaan A Voors, Marc A Vos, Michiel Rienstra, Isabelle C Van Gelder
Aims: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in systolic heart failure patients with ventricular conduction delay. Variability of individual response to CRT warrants improved patient selection. The Markers and Response to CRT (MARC) study was designed to investigate markers related to response to CRT. Methods and results: We prospectively studied the ability of 11 clinical, 11 electrocardiographic, 4 echocardiographic, and 16 blood biomarkers to predict CRT response in 240 patients...
February 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28332132/redefining-the-role-of-biomarkers-in-heart-failure-trials-expert-consensus-document
#3
REVIEW
Frank Kramer, Hani N Sabbah, James J Januzzi, Faiez Zannad, J Peter van Tintelen, Erik B Schelbert, Raymond J Kim, Hendrik Milting, Richardus Vonk, Brien Neudeck, Richard Clark, Klaus Witte, Wilfried Dinh, Burkert Pieske, Javed Butler, Mihai Gheorghiade
Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatments for heart failure. Biomarkers play an important role in patient selection and monitoring in drug trials and in clinical management. The present review gives an overview of the role of available molecular, imaging, and device-derived digital biomarkers in heart failure drug development and highlights capabilities and limitations of biomarker use in this context...
March 23, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28321399/renocardiovascular-biomarkers-from-the-perspective-of-managing-chronic-kidney-disease-and-cardiovascular-disease
#4
REVIEW
Shinichiro Niizuma, Yoshitaka Iwanaga, Takaharu Yahata, Shunichi Miyazaki
Mortality among the patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) remains high because of the very high incidence of cardiovascular disease (CVD) such as coronary artery disease, cardiac hypertrophy, and heart failure. Identifying CVD in patients with CKD/ESRD remains a significant hurdle and the early diagnosis and therapy for CVD is crucial in these patients. Therefore, it is necessary for the better management to identify and utilize cardiovascular (CV) biomarkers in profiling CVD risk and enabling stratification of early mortality...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28319523/plasma-levels-of-microrna-155-are-upregulated-with-long-term-left-ventricular-assist-device-support
#5
Teresa Wang, Emily C OʼBrien, Joseph G Rogers, Daniel L Jacoby, Michael E Chen, Jeffrey M Testani, Dawn E Bowles, Carmelo A Milano, G Michael Felker, Chetan B Patel, Pramod N Bonde, Tariq Ahmad
Left ventricular assist device (LVAD) therapy unloads the failing heart but exposes the human body to unique pathophysiological demands such as continuous blood-flow and complete univentricular support, which are associated with increased risk of adverse clinical outcomes. MiRNAs are 22-23 nucleotide RNAs involved in regulation of multiple biological processes including the pathogenesis of heart failure (HF). Thus, measurement of miRNAs may have potential in both diagnostics as circulating biomarkers, and in therapeutics for targeted interventions...
March 17, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28318874/metabolic-profile-provides-prognostic-value-better-than-galectin-3-in-patients-with-heart-failure
#6
Chao-Hung Wang, Mei-Ling Cheng, Min-Hui Liu, Li-Tang Kuo, Ming-Shi Shiao
BACKGROUND: Metabolic profiles have been shown to provide prognostic information in patients with heart failure (HF). Galectin-3 (Gal-3), indicating cardiac fibrosis, is a documented biomarker of prognosis in HF. It is unknown whether metabolic profiles provide prognostic value better than Gal-3. METHODS AND RESULTS: This study analyzed 212 hospitalized HF patients, measuring metabolic score (composed by butyrylcarnitine, dimethylarginine/arginine ratio, spermidine, and total essential amino acids) and Gal-3...
March 16, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28317477/circulating-biomarkers-of-collagen-metabolism-and-prognosis-of-heart-failure-with-reduced-or-mid-range-ejection-fraction
#7
Joana Moura Ferreira, Sara Moura Ferreira, Maria João Ferreira, Inês Falcão-Pires
BACKGROUND: Change in the architecture and composition of cardiac extracellular matrix is a key element in adverse cardiac remodeling that occurs during heart failure. Most of the times, the result is the development of fibrosis, which has a huge impact on the pathophysiology and clinical outcomes of heart failure syndromes. Several molecules related to collagen metabolism detectable in the blood have been proposed as biomarkers of myocardial fibrosis. Despite concerns regarding the true ability of these biomarkers to reflect quantitative and qualitative changes in myocardial collagen, a growing body of evidence suggests that they may play a potential role in several aspects of heart failure management...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28316175/-diagnostic-value-of-combining-serum-soluble-st2-and-interleukin-33-for-heart-failure-patients-with-preserved-left-ventricular-ejection-fraction
#8
N S Luo, H F Zhang, P M Liu, Y Q Lin, T C Huang, Y Yang, J F Wang
Objective: Diagnostic efficacy of serum markers is low for heart failure patients with preserved left ventricular ejection fraction (HF-pEF) as compared to heart failure patients with reduced left ventricular ejection fraction.We sought to explore the diagnostic value of serum levels of soluble ST2 (sST2) combined with interleukin-33 (IL-33) for the diagnosis of HF-pEF in this study. Methods: A total of 376 patients with HF-pEF (HF group), 376 matched-control patients without heart failure who shared similar clinical characteristics (non-HF group) were included in the study...
March 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28306681/anesthesia-in-adults-with-congenital-heart-disease
#9
Torsten Baehner, Richard K Ellerkmann
PURPOSE OF REVIEW: The current review focuses on patients with congenital heart disease (CHD) with regard to recent trends in global demographics, healthcare provision for noncardiac surgery, as well as anesthetic and perioperative care for these patients. RECENT FINDINGS: About 40 years after milestones of surgical innovation in CHD, the number of adults with CHD (ACHD) now surpasses those of children with CHD. This development leads to the fact that even patients with complex CHD managed for noncardiac surgery are not restricted to highly specialized centers...
March 16, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28306670/innovations-in-cardiac-transplantation
#10
Reema Hasan, Ashraf Abou El Ela, Daniel Goldstein
PURPOSE OF REVIEW: As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS: Preliminary studies into donation after cardiac death have indicated that this may be an effective means to increase the donor pool. Novel preservation techniques that include ex-vivo perfusion to improve donor metabolic stabilization prior to implantation may also expand the donor pool...
March 16, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28302916/advances-in-heart-failure-a-review-of-biomarkers-emerging-pharmacological-therapies-durable-mechanical-support-and-telemonitoring
#11
REVIEW
Yasbanoo Moayedi, Heather J Ross
The purpose of this review is to provide an overview of diagnosis, prognosis and management of heart failure (HF) with reduced ejection fraction (HFrEF). Specifically, this review is divided into three sections. The first section will address biomarkers. The discovery of biomarkers has allowed further understanding of the pathophysiology of HF and provides insight into potential therapeutic targets. This review will focus on novel applications of natriuretic peptides (NPs) in clinical trials. Next, emerging biomarkers of HF, such as ST2, galectin-3 and copeptin, will be discussed...
April 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28296139/measurement-of-troponin-and-natriuretic-peptides-shortly-after-admission-in-patients-with-heart-failure-does-it-add-useful-prognostic-information-an-analysis-of-the-value-of-endothelin-receptor-inhibition-with-tezosentan-in-acute-heart-failure-studies-veritas
#12
John G F Cleland, John R Teerlink, Beth A Davison, Ahmad Shoaib, Marco Metra, Stefanie Senger, Olga Milo, Gad Cotter, Robert C Bourge, John D Parker, Guillaume Jondeau, Henry Krum, Christopher M O'Connor, Guillermo Torre-Amione, Dirk J van Veldhuisen, John J V McMurray
OBJECTIVE: Plasma concentrations of B-type natriuretic peptide (BNP) and troponin are often measured for diagnostic purposes when patients are admitted with heart failure, but their prognostic value when measured soon after admission is uncertain. We aimed to investigate the added prognostic value of admission measurements of BNP and troponins in patients with acute heart failure. METHODS AND RESULTS: Multivariable prognostic models for death or any worsening heart failure (WHF) or rehospitalization for WHF by 30 days, 30-day death or rehospitalization for WHF, and 90-day mortality were constructed using baseline data from the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS) including BNP and troponin I...
March 10, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28296001/circulating-long-non-coding-rnas-nron-and-mhrt-as-novel-predictive-biomarkers-of-heart-failure
#13
Lina Xuan, Lihua Sun, Ying Zhang, Yuechao Huang, Yan Hou, Qingqi Li, Ying Guo, Bingbing Feng, Lina Cui, Xiaoxue Wang, Zhiguo Wang, Ye Tian, Bo Yu, Shu Wang, Chaoqian Xu, Mingyu Zhang, Zhimin Du, Yanjie Lu, Bao Feng Yang
This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for heart failure (HF). We measured the circulating levels of 13 individual lncRNAs which are known to be relevant to cardiovascular disease in the plasma samples from 72 HF patients and 60 non-HF control participants using real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) methods. We found that out of the 13 lncRNAs tested, non-coding repressor of NFAT (NRON) and myosin heavy-chain-associated RNA transcripts (MHRT) had significantly higher plasma levels in HF than in non-HF subjects: 3...
March 14, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28294871/-proton-transfer-reaction-mass-spectrometry-of-exhaled-breath-in-diagnostics-of-heart-failure
#14
Ph Yu Kopylov, A L Syrkin, P Sh Chomakhidze, A A Bykova, D Yu Shhekochihin, Yu R Shaltaeva, V V Belyakov, V S Pershenkov, N N Samotaev, A V Golovin, V K Vasil'ev, E K Malkin, E A Gromov, I A Ivanov, D Ju Lipatov, D Ju Yakovlev, V B Betelin
Exhaled breath analysis is one of directions in the search for novel biomarkers of chronic heart failure (CHF). According.
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28293796/low-circulating-microrna-levels-in-heart-failure-patients-are-associated-with-atherosclerotic-disease-and-cardiovascular-related-rehospitalizations
#15
Eline L Vegter, Ekaterina S Ovchinnikova, Dirk J van Veldhuisen, Tiny Jaarsma, Eugene Berezikov, Peter van der Meer, Adriaan A Voors
OBJECTIVE: Circulating microRNAs (miRNAs) have been implicated in both heart failure and atherosclerotic disease. The aim of this study was to examine associations between heart failure specific circulating miRNAs, atherosclerotic disease and cardiovascular-related outcome in patients with heart failure. METHODS: The levels of 11 heart failure-specific circulating miRNAs were compared in plasma of 114 heart failure patients with and without different manifestations of atherosclerotic disease...
March 14, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28292573/-use-of-micrornas-in-heart-failure-management
#16
Luis Alejandro Arias Sosa
Heart failure (HF) is a high impact disease that affects all human populations, demanding the development of new strategies and methods to manage this pathology. That's why microRNAs, small noncoding RNAs that regulate gene expression, appear as an important option in the diagnosis, prognosis and treatment of this disease. MiRNAs seems to have a future on HF handling, because can be isolated from body fluids such as blood, and changes in its levels can be associated with the presence, stage and specific disease features, which makes them an interesting option as biomarkers...
March 11, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28290833/-soluble-suppression-of-tumorogenicity-2-increases-opportunities-for-risk-stratification-after-acute-heart-failure-decompensation
#17
A A Skvortsov, V N Protasov, O Yu Narusov, D E Koshkina, S N Nasonova, V P Masenko, S N Tereschenko
PURPOSE: to evaluate the significance of soluble ST2-receptor (sST2) concentrations in patient (pts) risk stratification in with acute decompensated heart failure (ADHF) during long-term follow-up period. METHODS: In the prospective single-center study were included 159 pts with ADHF III-IV FC NYHA. Blood samples to determine NT-proBNP, sST2, hsTnT concentration were collected at the admission and at discharge from the hospital, and after 3, 6 and 12 months of follow-up...
January 2017: Kardiologiia
https://www.readbyqxmd.com/read/28288987/plasma-and-cardiac-galectin-3-in-patients-with-heart-failure-reflects-both-inflammation-and-fibrosis-implications-for-its-use-as-a-biomarker
#18
Christian Besler, David Lang, Daniel Urban, Karl-Philipp Rommel, Maximilian von Roeder, Karl Fengler, Stephan Blazek, Reinhard Kandolf, Karin Klingel, Holger Thiele, Axel Linke, Gerhard Schuler, Volker Adams, Philipp Lurz
BACKGROUND: Galectin (Gal)-3 is a β-galactoside-binding lectin and currently intensely studied as a biomarker in heart failure. Gal-3 also exerts proinflammatory effects, at least in extracardiac tissues. Objective of this study was to characterize the relationship of plasma and myocardial Gal-3 levels with cardiac fibrosis and inflammation in patients with nonischemic dilated cardiomyopathy and inflammatory cardiomyopathy (iCMP). METHODS AND RESULTS: Endomyocardial biopsies and blood samples were obtained from patients with newly diagnosed cardiomyopathy and clinical suspicion of myocarditis...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28287031/comparison-of-diverse-platelet-activation-markers-as-indicators-for-left-atrial-thrombus-in-atrial-fibrillation
#19
Daniel Tarnowski, David M Poitz, Lina Plichta, Felix M Heidrich, Stephan Wiedemann, Tobias Ruf, Johannes Mierke, Tobias Löhn, Stefanie Jellinghaus, Ruth H Strasser, Karim Ibrahim, Christian Pfluecke
Atrial fibrillation (AF) is well known for being a major risk factor of thromboembolic stroke. We could recently demonstrate an association of monocyte-platelet aggregates (MPAs) with the degree of thrombogenicity in patients with AF. This study investigated platelet activation markers, as potential biomarkers for the presence of left atrial (LA) thrombus in patients with AF. One hundred and eight patients with symptomatic AF underwent transesophageal echocardiography (TEE) before scheduled cardioversion or pulmonary vein isolation...
March 13, 2017: Platelets
https://www.readbyqxmd.com/read/28285269/cancer-antigen-125-plasma-level-as-a-biomarker-of-new-onset-atrial-fibrillation-in-postmenopausal-women
#20
Haruki Sekiguchi, Ken Shimamoto, Mayu Takano, Makiko Kimura, Yufuko Takahashi, Fujio Tatsumi, Eri Watanabe, Kentaro Jujo, Naoko Ishizuka, Masatoshi Kawana, Nobuhisa Hagiwara
OBJECTIVE: Plasma cancer antigen (CA)-125 is a tumour marker recently shown to be associated with systolic heart failure and new-onset atrial fibrillation (AF) after myocardial infarction. However, no reports have described the relationship between CA-125 and new-onset AF in healthy postmenopausal women. The aim of the present study was to evaluate the relationship between CA-125 and new-onset AF in postmenopausal women. METHODS: Between 2005 and 2015, 2086 women, including 1012 postmenopausal women, visited our hospital for annual health check-ups...
March 11, 2017: Heart: Official Journal of the British Cardiac Society
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