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Heart failure biomarkers

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https://www.readbyqxmd.com/read/29455180/takotsubo-syndrome-in-a-premenopausal-patient
#1
Maria Menezes, Daniela Marto, Isabel Marcão, Catarina Salvado
Takotsubo syndrome is a rare clinical condition, with a pathophysiology that is not fully understood. Characterised by an acute and usually reversible heart failure, the condition is often preceded by a stressful event. For the diagnosis of Takotsubo syndrome to be possible, the absence of coronary artery disease as a cause is required. We report a case of Takotsubo syndrome in a 47-year-old woman of fertile age. Electrical and echocardiographic presentations were classical in the patient. However, abnormally elevated cardiac biomarkers were registered...
February 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29454783/comparison-of-the-diastolic-stress-test-with-a-combined-resting-echocardiography-and-biomarker-approach-to-patients-with-exertional-dyspnea-diagnostic-and-prognostic-implications
#2
Wojciech Kosmala, Monika Przewlocka-Kosmala, Aleksandra Rojek, Thomas H Marwick
OBJECTIVES: This study sought to establish the diagnostic and prognostic value of a strategy for prediction of abnormal diastolic response to exercise (AbnDR) using clinical, biochemical, and resting echocardiographic markers in dyspneic patients with mild diastolic dysfunction. BACKGROUND: An AbnDR (increase in left ventricular filling pressure) may indicate heart failure with preserved ejection fraction as the cause of symptoms in dyspneic patients, despite a nonelevated noncardiac at rest...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29450407/changes-in-the-cardiac-ghsr1a-ghrelin-system-correlate-with-myocardial-dysfunction-in-diabetic-cardiomyopathy-in-mice
#3
Rebecca Sullivan, Rebecca McGirr, Shirley Hu, Alice Tan, Derek Wu, Carlie Charron, Tyler Lalonde, Edith Arany, Subrata Chakrabarti, Leonard Luyt, Savita Dhanvantari
Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are present in cardiac tissue. Activation of GHSR1a by ghrelin promotes cardiomyocyte contractility and survival, and changes in myocardial GHSR1a and circulating ghrelin track with end-stage heart failure, leading to the hypothesis that GHSR1a is a biomarker for heart failure. We hypothesized that GHSR1a could also be a biomarker for diabetic cardiomyopathy (DCM). We used two models of streptozotocin (STZ)-induced DCM: group 1, adult mice treated with 35 mg/kg STZ for 3 days; and group 2, neonatal mice treated with 70 mg/kg STZ at days 2 and 5 after birth...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29449366/use-of-serum-transthyretin-as-a-prognostic-indicator-and-predictor-of-outcome-in-cardiac-amyloid-disease-associated-with-wild-type-transthyretin
#4
Jacquelyn L S Hanson, Marios Arvanitis, Clarissa M Koch, John L Berk, Frederick L Ruberg, Tatiana Prokaeva, Lawreen H Connors
BACKGROUND: Wild-type transthyretin amyloidosis (ATTRwt), an underappreciated cause of heart failure in older adults, is challenging to diagnose and monitor in the absence of validated, disease-specific biomarkers. We examined the prognostic use and survival association of serum TTR (transthyretin) concentration in ATTRwt. METHODS AND RESULTS: Patients with biopsy-proven ATTRwt were retrospectively identified. Serum TTR, cardiac biomarkers, and echocardiographic parameters were assessed at baseline and follow-up evaluations...
February 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29448998/cardiac-amyloidosis-from-clinical-suspicion-to-morphological-diagnosis
#5
REVIEW
Pavla Flodrova, Patrik Flodr, Tomas Pika, Jiri Vymetal, Dusan Holub, Petr Dzubak, Marian Hajduch, Vlastimil Scudla
Amyloidosis is a heterogeneous group of diseases characterised by extracellular accumulation of amyloid in various tissues and organs of the body, leading to alteration and destruction of tissues. Heart involvement is the most important prognostic factor in patients with systemic amyloidosis and the diagnosis and typing of amyloid must be made properly. The clinical picture shows congestive heart failure with predominant right-sided heart failure symptoms in fully developed disease, various types of arrhythmias and characteristic electrocardiography and echocardiography findings...
February 12, 2018: Pathology
https://www.readbyqxmd.com/read/29438982/micrornas-associated-with-reverse-left-ventricular-remodeling-in-humans-identify-pathways-of-heart-failure-progression
#6
Ravi Shah, Olivia Ziegler, Ashish Yeri, Xiaojun Liu, Venkatesh Murthy, Dustin Rabideau, Chun Yang Xiao, Kristina Hanspers, Arianna Belcher, Michael Tackett, Anthony Rosenzweig, Alexander R Pico, James L Januzzi, Saumya Das
BACKGROUND: Plasma extracellular RNAs have recently garnered interest as biomarkers in heart failure (HF). Most studies in HF focus on single extracellular RNAs related to phenotypes and outcomes, and few describe their functional roles. We hypothesized that clusters of plasma microRNAs (miRNAs) associated with left ventricular (LV) remodeling in human HF would identify novel subsets of genes involved in HF in animal models. METHODS AND RESULTS: We prospectively measured circulating miRNAs in 64 patients with systolic HF (mean age, 64...
February 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29437599/-malignant-left-ventricular-hypertrophy-identifies-subjects-at-high-risk-for-progression-to-asymptomatic-left-ventricular-dysfunction-heart-failure-and-death-mesa-multi-ethnic-study-of-atherosclerosis
#7
Matthew N Peters, Stephen L Seliger, Robert H Christenson, Susie N Hong-Zohlman, Lori B Daniels, Joao A C Lima, James A de Lemos, Ian J Neeland, Christopher R deFilippi
BACKGROUND: As heart failure (HF)-associated morbidity and mortality continue to escalate, enhanced focus on prevention is increasingly important. "Malignant" left ventricular (LV) hypertrophy (LVH): LVH combined with an elevated cardiac biomarker reflecting either injury (high-sensitivity cardiac troponin T), or strain (amino-terminal pro-B-type natriuretic peptide) has predicted accelerated progression to HF. We sought to determine whether malignant LVH identified community-dwelling adults initially free of cardiovascular disease at high risk of asymptomatic decline in LV ejection fraction or a clinical cardiovascular event...
February 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29433967/role-of-myocardial-collagen-degradation-and-fibrosis-in-right-ventricle-dysfunction-in-transposition-of-the-great-arteries-after-atrial-switch
#8
Magalie Ladouceur, Stephanie Baron, Valérie Nivet-Antoine, Gérard Maruani, Gilles Soulat, Helena Pereira, Anne Blanchard, Pierre Boutouyrie, Jean Louis Paul, Elie Mousseaux
BACKGROUND: Heart failure is a serious event in patients with transposition of the great arteries (D-TGA) after atrial redirection surgery. We aimed to determine the association between myocardial fibrosis and systolic and diastolic systemic right ventricle (sRV) dysfunction. METHODS: Diastolic and systolic function of sRV was prospectively assessed using echocardiography and cardiac magnetic resonance imaging (CMR) in 48 patients with atrially switched D-TGA and 26 healthy subjects...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29431103/interaction-of-body-mass-index-on-the-association-between-n-terminal-pro-b-type-natriuretic-peptide-and-morbidity-and-mortality-in-patients-with-acute-heart-failure-findings-from-ascend-hf-acute-study-of-clinical-effectiveness-of-nesiritide-in-decompensated
#9
Ankeet S Bhatt, Lauren B Cooper, Andrew P Ambrosy, Robert M Clare, Adrian Coles, Emer Joyce, Arun Krishnamoorthy, Javed Butler, G Michael Felker, Justin A Ezekowitz, Paul W Armstrong, Adrian F Hernandez, Christopher M O'Connor, Robert J Mentz
BACKGROUND: Higher body mass index (BMI) is associated with lower circulating levels of N-terminal-pro-b-type natriuretic peptide (NT-proBNP). The Interaction between BMI and NT-proBNP with respect to clinical outcomes is not well characterized in patients with acute heart failure. METHODS AND RESULTS: A total of 686 patients from the biomarker substudy of the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated HF ) clinical trial with documented NT-proBNP levels at baseline were included in the present analysis...
February 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29430747/left-atrial-rather-than-left-ventricular-impaired-mechanics-are-associated-with-the-pro-fibrotic-st2-marker-and-outcomes-in-heart-failure-with-preserved-ejection-fraction
#10
A I Nagy, C Hage, B Merkely, E Donal, J-C Daubert, C Linde, L H Lund, A Manouras
AIMS: Left ventricular (LV) mechanics have been extensively investigated in heart failure with preserved ejection fraction (HFpEF) overshadowing for a long time the potential role of left atrium (LA) in that setting. Soluble suppression of tumorigenicity-2 receptor (ST2) is a novel biomarker of pro-fibrotic burden in HF. We hypothesized that due to the thinner LA wall, the fibrotic myocardial changes in HFpEF as indicated by elevated ST2 levels might more readily be reflected by impairments in the LA rather than the LV performance...
February 12, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29429401/evaluation-of-serum-neutrophil-gelatinase-associated-lipocalin-as-a-novel-biomarker-of-cardiorenal-syndrome-in-dogs
#11
Han-Byeol Jung, Min-Hee Kang, Hee-Myung Park
Worsening renal function and azotemia in patients with heart failure (HF) are strongly associated with disease severity and poor prognosis. Increasing interest in this correlation led to the description and classification of cardiorenal syndrome (CRS). We evaluated the role of neutrophil gelatinase-associated lipocalin (NGAL) in the early detection of CRS in dogs with HF. Ten healthy dogs and 31 dogs admitted with HF were included in our study. NGAL and troponin-I were measured on samples collected on the day of admission; creatinine was measured on admission and again on day 7...
February 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29428439/using-nt-probnp-for-eligibility-and%C3%A2-enrichment-in-trials-in-hfpef-hfmref-%C3%A2-and-hfref
#12
Gianluigi Savarese, Nicola Orsini, Camilla Hage, Ola Vedin, Francesco Cosentino, Giuseppe M C Rosano, Ulf Dahlström, Lars H Lund
OBJECTIVES: The purpose of this study was to assess the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiovascular (CV) versus non-CV events and between NT-proBNP and potential treatment effects in heart failure (HF) with preserved, mid-range, and reduced ejection fraction (HFpEF, HFmrEF, and HFrEF, respectively) and clinically relevant subgroups. BACKGROUND: Optimizing patient eligibility criteria in HF trials requires biomarkers that enrich for CV but not for non-CV events and select patients most likely to respond to the tested intervention...
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428199/elevated-soluble-st2-concentration-may-involve-in-the-progression-of-atrial-fibrillation
#13
Xu Ma, Hui Yuan, Hai-Xia Luan, Ya-Li Shi, Xiao-Li Zeng, Yan Wang
BACKGROUND: The aim of this study is to investigate the value of soluble suppression of tumorigenicity 2 (sST2) in Atrial fibrillation (AF) patients' risk prediction. METHODS: Healthy people (n = 60) and AF patients (n = 194) were consecutively enrolled into this project. RESULTS: In the health group, the mean age was 54 y (55% males). Serum median concentration of sST2 in healthy individuals was 17.04 ng/ml. In the AF patients group, the mean age was 61 years, and 64% were males...
February 8, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29425051/carbohydrate-antigen-125-a-promising-tool-for-risk-stratification-in-heart-diseases
#14
Felipe Falcão, Flávio R A de Oliveira, Flávio R A de Oliveira, Maria Cleide F C da Silva, Dário C Sobral Filho
All patients with heart diseases should undergo risk stratification to predict those who are at high risk for short- and long-term adverse outcomes. Carbohydrate antigen 125 (CA125) is a glycoprotein produced by mesothelium that has clinical role in ovarian cancer monitoring. However, as it is not specific for ovarian cells, CA125 could also be used in heart diseases to monitor congestion and inflammation. Pericarditis, atrial fibrillation, heart failure and coronary artery disease are some scenarios in which this biomarker was studied...
February 9, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29424484/acute-heart-failure-following-myocardial-infarction-complement-activation-correlates-with-the-severity-of-heart-failure-in-patients-developing-cardiogenic-shock
#15
Hilde L Orrem, Per H Nilsson, Søren E Pischke, Guro Grindheim, Peter Garred, Ingebjørg Seljeflot, Trygve Husebye, Pål Aukrust, Arne Yndestad, Geir Ø Andersen, Andreas Barratt-Due, Tom E Mollnes
AIMS: Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction. METHODS AND RESULTS: The LEAF trial (LEvosimendan in Acute heart Failure following myocardial infarction) evaluating 61 patients developing HF within 48 h after percutaneous coronary intervention-treated ST-elevation myocardial infarction herein underwent a post hoc analysis...
February 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29424483/the-glycoproteomics-mass-spectrometry-for-studying-glycosylation-in-cardiac-hypertrophy-and-heart-failure
#16
REVIEW
Shuang Yang, Subroto Chatterjee, John Cipollo
With recent advancements of analytical techniques and mass spectrometric instrumentations, proteomics has been widely exploited to study the regulation of protein expression associated with disease states. Many proteins may undergo abnormal change in response to the stimulants, leading to regulation of post-translationally modified proteins. In this review, we discuss the physiological and pathological roles of protein glycosylation in cardiac hypertrophy, and how the signal pathways regulate heart function and leading to heart failure...
February 9, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29417868/non-coding-rnas-as-therapeutic-targets-for-preventing-myocardial-ischemia-reperfusion-injury
#17
Sang-Bing Ong, Khairunnisa Katwadi, Xiu-Yi Kwek, Nur Izzah Ismail, Sang-Ging Ong, Kroekkiat Chinda, Derek J Hausenloy
New treatments are required to improve clinical outcomes in patients with acute myocardial infarction (AMI), for reduction of myocardial infarct (MI) size and preventing heart failure. Following AMI, acute ischemia/reperfusion injury (IRI) ensues, resulting in cardiomyocyte death and impaired cardiac function. Emerging studies have implicated a fundamental role for non-coding RNAs (microRNAs [miRNA], and more recently long non-coding RNAs [lncRNA]) in the setting of acute myocardial IRI. Areas covered: In this article, we discuss the roles of miRNAs and lncRNAs as potential biomarkers and therapeutic targets for the detection and treatment of AMI, review their roles as mediators and effectors of cardioprotection, particularly in the settings of interventions such as ischemic pre- and post-conditioning (IPC & IPost) as well as remote ischemic conditioning (RIC), and highlight future strategies for targeting ncRNAs to reduce MI size and prevent heart failure following AMI...
February 8, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29417184/galectin-3-is-independently-associated-with-progression-of-nephropathy-in-type-2-diabetes-mellitus
#18
Kathryn C B Tan, Ching-Lung Cheung, Alan C H Lee, Joanne K Y Lam, Ying Wong, Sammy W M Shiu
AIMS/HYPOTHESIS: Galectin-3 has been implicated in cardiac and renal fibrosis and serves as a prognostic clinical indicator in heart failure. The aim of the present study was to evaluate whether serum galectin-3 level is associated with progressive kidney disease in type 2 diabetes. METHODS: Galectin-3 was measured in baseline samples by ELISA in 1320 participants with type 2 diabetes with eGFR ≥30 ml min-1 1.73 m-2. The primary outcome was defined as doubling of serum creatinine and/or initiation of renal replacement therapy during follow-up...
February 7, 2018: Diabetologia
https://www.readbyqxmd.com/read/29415801/bio-profiling-and-bio-prognostication-of-chronic-heart-failure-with-mid-range-ejection-fraction
#19
Pedro Moliner, Josep Lupón, Jaume Barallat, Marta de Antonio, Mar Domingo, Julio Núñez, Elisabet Zamora, Amparo Galán, Javier Santesmases, Cruz Pastor, Antoni Bayes-Genis
BACKGROUND: Recent ESC guidelines on heart failure (HF) have introduced a new phenotype based on left ventricular ejection fraction (LVEF), called the mid-range (HFmrEF). This phenotype falls between the classical reduced (HFrEF) and preserved (HFpEF) HF phenotypes. We aimed to characterize the HFmrEF biomarker profile and outcomes. METHODS: 1069 consecutive ambulatory patients were included in the study (age 66.2 ± 12.8 years); 800 with HFrEF (74.8%), 134 with HFmrEF (12...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29411335/evolving-role-of-natriuretic-peptides-from-diagnostic-tool-to-therapeutic-modality
#20
Ines Pagel-Langenickel
Natriuretic peptides (NP) are widely recognized as key regulators of blood pressure, water and salt homeostasis. In addition, they play a critical role in physiological cardiac growth and mediate a variety of biological effects including antiproliferative and anti-inflammatory effects in other organs and tissues. The cardiac release of NPs ANP and BNP represents an important compensatory mechanism during acute and chronic cardiac overload and during the pathogenesis of heart failure where their actions counteract the sustained activation of renin-angiotensin-aldosterone and other neurohormonal systems...
February 7, 2018: Advances in Experimental Medicine and Biology
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