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Heart failure biomarkers

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https://www.readbyqxmd.com/read/29673559/prognostic-value-of-the-urea-creatinine-ratio-in-decompensated-heart-failure-and-its-relationship-with-acute-kidney-damage
#1
C Josa-Laorden, A Sola, I Giménez-López, J Rubio-Gracia, V Garcés-Horna, J I Pérez-Calvo
BACKGROUND: Worsening renal function is associated with an adverse prognosis for patients with acute heart failure (AHF). Urea-creatinine ratio (U:C ratio) might be useful for measuring renal function and could help stratify patients with AHF. MATERIAL AND METHODS: An observational and prospective study was conducted to analyse the prognostic value of the U:C ratio, measured during the first 24-28 hours of admission, for patients hospitalised for decompensated Heart failure, and its relationship with estimated glomerular filtration rate (eGFR) and acute kidney injury (AKI)...
April 16, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29673259/exploring-potential-biomarkers-associated-with-health-related-quality-of-life-in-patients-with-coronary-artery-disease-and-heart-failure
#2
Nijole Kazukauskiene, Julius Burkauskas, Jurate Macijauskiene, Narseta Mickuviene, Julija Brozaitiene
OBJECTIVE: There has been a lack of research examining associations between biomarkers and health-related quality of life (HRQoL) in patients with coronary artery disease and heart failure. In patients with coronary artery disease and heart failure, we aimed to explore potential associations between biomarkers of health such as serum levels of thyroid hormones, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), inflammatory biomarkers and HRQoL. METHODS: In sum, 482 patients (75% male; mean age 58±10 years) with coronary artery disease and heart failure were evaluated for socio-demographic and clinical coronary artery disease risk factors...
April 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29672210/prognostic-utility-of-stress-testing-and-cardiac-biomarkers-in-menopausal-women-at-low-to-intermediate-risk-for-coronary-artery-disease-smart-study-5-year-outcome
#3
Sahar S Abdelmoneim, Caroline A Ball, Francesca Mantovani, Mary E Hagen, Susan Eifert-Rain, Susan Wilansky, Ramon Castello, Patricia A Pellikka, Patricia J M Best, Sharon L Mulvagh
BACKGROUND: In women with low to intermediate risk of coronary artery disease (CAD), prognostic detection strategies have been controversial. We present the follow-up data of the SMART trial in peri/postmenopausal women at low to intermediate risk of CAD. OBJECTIVES: To determine the value of contrast stress echocardiography (CSE), stress electrocardiogram (sECG), and serum biomarkers for prediction of cardiovascular events (CE) in peri/postmenopausal women at low to intermediate risk of CAD...
April 19, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29667356/early-identification-of-acute-heart-failure-at-the-time-of-presentation-do-natriuretic-peptides-make-the-difference
#4
Martin Möckel, Stephan von Haehling, Jörn O Vollert, Jan C Wiemer, Stefan D Anker, Alan Maisel
BACKGROUND: The early identification of patients with acute heart failure (AHF) is challenging as many other diseases lead to a clinical presentation with dyspnea. AIM: The aim of the study was to evaluate the impact of natriuretic peptides at common HF study cut-offs on the diagnosis of patients with dyspnea at admission. METHODS AND RESULTS: For this post hoc analysis, we analysed n = 726 European Union (EU) patients from the prospective BACH (Biomarkers in Acute Heart Failure) study...
April 18, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29667019/what-is-new-in-heart-failure-management-in-2017-update-on-acc-aha-heart-failure-guidelines
#5
REVIEW
Biykem Bozkurt
PURPOSE OF REVIEW: The goal of this paper is to provide a summary of the new recommendations in the most recent 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. The intent is to provide the background and the supporting evidence for the recommendations and to provide practical guidance for management strategies in treatment of heart failure patients...
April 17, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29663841/novel-heart-failure-biomarkers-why-do-we-fail-to-exploit-their-potential
#6
Arnold Piek, Weijie Du, Rudolf A de Boer, Herman H W Silljé
Plasma biomarkers are useful tools in the diagnosis and prognosis of heart failure (HF). In the last decade, numerous studies have aimed to identify novel HF biomarkers that would provide superior and/or additional diagnostic, prognostic, or stratification utility. Although numerous biomarkers have been identified, their implementation in clinical practice has so far remained largely unsuccessful. Whereas cardiac-specific biomarkers, including natriuretic peptides (ANP and BNP) and high sensitivity troponins (hsTn), are widely used in clinical practice, other biomarkers have not yet proven their utility...
April 17, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29663512/specific-biomarkers-of-myocardial-inflammation-and-remodeling-processes-as-predictors-of-mortality-in-high-risk-patients-undergoing-percutaneous-mitral-valve-repair-mitraclip
#7
Oliver Dörr, Claudia Walther, Christoph Liebetrau, Till Keller, Hannes Tabert, Niklas Boeder, Matthias Bayer, Pascal Bauer, Helge Möllmann, Luise Gaede, Christian Troidl, Sandra Voss, Timm Bauer, Christian W Hamm, Holger Nef
BACKGROUND: Specific matrix metalloproteinases (MMP-2, MMP-9) and inflammatory biomarkers (hsCRP, IL-6) were found to be consistently up-regulated in severe mitral valve regurgitation (MR) and are associated with mortality in heart failure patients. The aim of the present study was to examine the prognostic value of biomarkers of cardiac inflammation and remodeling processes in predicting mortality in patients with MR undergoing percutaneous mitral valve repair (PMVR). HYPOTHESIS: We hypothesize that increased cardiac inflammation and extracellular matrix turnover is predictive for mortality in patients with severe mitral regurgitation undergoing MitraClip...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29656848/the-discipline-of-epidemiology-engaging-in-the-full-breadth-of-population-health-science
#8
EDITORIAL
Harold I Feldman
This address was delivered by Harold I. Feldman, MD, MSCE, at the Annual Meeting of the American College of Epidemiology in New Orleans, Louisiana, on September 26, 2017. Dr. Feldman is George S. Pepper Professor of Public Health and Preventive Medicine, Professor of Epidemiology and Medicine, and Chair, Department of Biostatistics, Epidemiology, and Informatics at the Perelman School of Medicine at the University of Pennsylvania. He is recognized nationally and internationally for his expertise in kidney disease epidemiology...
March 21, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29655458/standardization-of-bnp-and-nt-probnp-immunoassays-in-light-of-the-diverse-and-complex-nature-of-circulating-bnp-related-peptides
#9
Alexander G Semenov, Evgeniya E Feygina
Brain natriuretic peptide (BNP) and the N-terminal fragment of the BNP precursor (NT-proBNP) are widely used as heart failure (HF) biomarkers. Since the discovery of BNP in 1988, much effort has been allocated to the precise detection of BNP and NT-proBNP levels for reliable HF diagnostics. As a result, measurements of these biomarkers are globally accepted and used in clinical practice for the diagnosis of acute and chronic HF, risk stratification, and monitoring response to therapy. Several immunoassays specific for BNP and NT-proBNP are currently commercially available...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29650706/pro-inflammatory-biomarkers-in-stable-versus-acutely-decompensated-heart-failure-with-preserved-ejection-fraction
#10
Abraham Abernethy, Sadi Raza, Jie-Lena Sun, Kevin J Anstrom, Russell Tracy, Johannes Steiner, Peter VanBuren, Martin M LeWinter
BACKGROUND: Underlying inflammation has been increasingly recognized in heart failure with a preserved ejection fraction (HFpEF). In this study we tested the hypothesis that pro-inflammatory biomarkers are elevated in patients with acutely decompensated HFpEF (AD-HFpEF) compared with patients with stable HFpEF (S-HFpEF). METHODS AND RESULTS: Using a post hoc analysis the serum biomarkers tumor necrosis factor-alpha, high-sensitivity C-reactive protein interleukin 6 and pentraxin 3 (PTX3) and clinical, demographic, echocardiographic-Doppler and clinical outcomes data were analyzed in HFpEF patients enrolled in NHLBI Heart Failure Research Network clinical trials which enrolled patients with either AD-HFpEF or S-HFpEF...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29650126/myocardial-interstitial-fibrosis-in-heart-failure-biological-and-translational-perspectives
#11
REVIEW
Arantxa González, Erik B Schelbert, Javier Díez, Javed Butler
Myocardial interstitial fibrosis contributes to left ventricular dysfunction leading to the development of heart failure. Basic research has provided abundant evidence for the cellular and molecular mechanisms behind this lesion and the pathways by which it imparts a detrimental impact on cardiac function. Translation of this knowledge, however, to improved diagnostics and therapeutics for patients with heart failure has not been as robust. This is partly related to the paucity of biomarkers to accurately identify myocardial interstitial fibrosis and to the lack of personalized antifibrotic strategies to treat it in an effective manner...
April 17, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29648475/alterations-in-plasma-l-arginine-and-methylarginines-in-heart-failure-and-after-heart-transplantation
#12
Jakob Lundgren, Anna Sandqvist, Mikael Hedeland, Ulf Bondesson, Gerhard Wikström, Göran Rådegran
OBJECTIVE: Endothelial function, including the nitric oxide (NO)-pathway, has previously been extensively investigated in heart failure (HF). In contrast, studies are lacking on the NO pathway after heart transplantation (HT). We therefore investigated substances in the NO pathway prior to and after HT in relation to hemodynamic parameters. DESIGN: 12 patients (median age 50.0 yrs, 2 females), heart transplanted between June 2012 and February 2014, evaluated at our hemodynamic lab, at rest, prior to HT, as well as four weeks and six months after HT were included...
April 12, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29644505/cardiotoxicity-of-immunotherapy-incidence-diagnosis-and-management
#13
REVIEW
Aarti Asnani
PURPOSE OF REVIEW: This review describes cardiotoxicity associated with adoptive T cell therapy and immune checkpoint blockade. RECENT FINDINGS: Cardiotoxicity is a rare but potentially fatal complication associated with novel immunotherapies. Both affinity-enhanced and chimeric antigen receptor T cells have been reported to cause hypotension, arrhythmia, and left ventricular dysfunction, typically in the setting of cytokine release syndrome. Immune checkpoint inhibitors are generally well-tolerated but have the potential to cause myocarditis, with clinical presentations ranging from asymptomatic cardiac biomarker elevation to heart failure, arrhythmia, and cardiogenic shock...
April 11, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29625179/proteostasis-in-epicardial-versus-subcutaneous-adipose-tissue-in-heart-failure-subjects-with-and-without-diabetes
#14
A Burgeiro, A C Fonseca, D Espinoza, L Carvalho, N Lourenço, M Antunes, E Carvalho
BACKGROUND: Cardiovascular diseases (CVDs) are leading cause of death and primary cause of morbidity and mortality in diabetic population. Epicardial adipose tissue (EAT) covers the heart's surface and is a source of biomolecules regulating heart and blood vessel physiology. The protective activation of the unfolded protein response (UPR) and autophagy allows the cardiomyocyte reticular network to restore energy and/or nutrient homeostasis and to avoid cell death. However, an excessive or prolonged UPR activation can trigger cell death...
April 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29623546/exercise-rehabilitation-in-ventricular-assist-device-recipients-a-meta-analysis-of-effects-on-physiological-and-clinical-outcomes
#15
REVIEW
Liza Grosman-Rimon, Spencer D Lalonde, Nina Sieh, Maureen Pakosh, Vivek Rao, Paul Oh, Sherry L Grace
Exercise rehabilitation in heart failure patients has been shown to improve quality of life (QoL) and survival. It is also recommended in clinical practice guidelines for ventricular assist device (VAD) recipients. However, there have only been two meta-analyses on the effects of exercise rehabilitation in VAD patients, on only two outcomes. The objective of the review was to quantitatively evaluate the effect of exercise rehabilitation in VAD recipients on functional capacity, exercise physiology parameters, chronotropic responses, inflammatory biomarkers and neurohormones, heart structure and function, and clinical outcomes...
April 6, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29619925/the-validity-of-the-diagnosis-of-heart-failure-i50-0-i50-9-in-the-danish-national-patient-register
#16
Joanna Delekta, Steen Møller Hansen, Karam Sadoon AlZuhairi, Christian Sørensen Bork, Albert Marni Joensen
INTRODUCTION: National discharge registers are important and cost-effective data sources for administrative and research purposes, but their value depends much on the validity of the registered data. The objective of this study was to assess the validity of heart failure (HF) diagnoses (ICD10: I50.0-I50.9) in the Danish National Patient Register (DNPR). METHODS: We reviewed medical records from a random sample of 500 patients with either a primary or a secondary discharge diagnosis of HF registered in the DNPR from any department in Northern Denmark in 2007...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29617523/effects-of-sacubitril-valsartan-on-physical-and-social-activity-limitations-in-patients-with-heart-failure-a-secondary-analysis-of-the-paradigm-hf-trial
#17
Alvin Chandra, Eldrin F Lewis, Brian L Claggett, Akshay S Desai, Milton Packer, Michael R Zile, Karl Swedberg, Jean L Rouleau, Victor C Shi, Martin P Lefkowitz, Tzvetana Katova, John J V McMurray, Scott D Solomon
Importance: Health-related quality of life (HRQL) of patients with heart failure is markedly reduced compared with that in patients with other chronic diseases, demonstrating substantial limitations in physical and social activities. In the Prospective Comparison of ARNI With an ACE-Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial, sacubitril/valsartan improved overall HRQL compared with enalapril, as determined by the Kansas City Cardiomyopathy Questionnaire (KCCQ)...
April 4, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29616374/heart-failure-with-recovered-ef-and-heart-failure-with-mid-range-ef-current-recommendations-and-controversies
#18
REVIEW
Peter Unkovic, Anupam Basuray
PURPOSE OF REVIEW: This review explores key features and potential management controversies in two emerging populations in heart failure: heart failure with recovered ejection fraction (HF-recovered EF) and heart failure with mid-range ejection fraction (HFmrEF). RECENT FINDINGS: While HF-recovered EF patients have better outcomes than heart failure with reduced ejection fraction (HFrEF), they continue to have symptoms, persistent biomarker elevations, and abnormal outcomes suggesting a continued disease process...
April 3, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29615435/association-of-biomarker-clusters-with-cardiac-phenotypes-and-mortality-in-patients-with-hiv-infection
#19
Rebecca Scherzer, Sanjiv J Shah, Eric Secemsky, Javed Butler, Carl Grunfeld, Michael G Shlipak, Priscilla Y Hsue
BACKGROUND: Although individual cardiac biomarkers are associated with heart failure risk and all-cause mortality in HIV-infected individuals, their combined use for prediction has not been well studied. METHODS AND RESULTS: Unsupervised k-means cluster analysis was performed blinded to the study outcomes in 332 HIV-infected participants on 8 biomarkers: ST2, NT-proBNP (N-terminal pro-B-type natriuretic peptide), hsCRP (high-sensitivity C-reactive protein), GDF-15 (growth differentiation factor 15), cystatin C, IL-6 (interleukin-6), D-dimer, and troponin...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29607528/changes-in-myocardial-iron-content-following-administration-of-intravenous-iron-myocardial-iron-study-design
#20
Gema Miñana, Ingrid Cardells, Patricia Palau, Pau Llàcer, Lorenzo Fácila, Luis Almenar, Maria Pilar López-Lereu, Jose V Monmeneu, Martina Amiguet, Jessika González, Alicia Serrano, Vicente Montagud, Raquel López-Vilella, Ernesto Valero, Sergio García-Blas, Vicent Bodí, Rafael de la Espriella-Juan, Juan Sanchis, Francisco J Chorro, Antoni Bayés-Genís, Julio Núñez
BRIEF TRIAL SUMMARY BACKGROUND: Treatment with intravenous ferric carboxymaltose (FCM) showed to improve symptoms, functional capacity, and quality of life in patients with heart failure (HF) and iron deficiency (ID). However, the underlying mechanisms for these beneficial effects remain undetermined. The aim of this study is to quantify cardiac magnetic resonance (CMR) changes in myocardial iron content after administration of intravenous FCM in patients with HF and ID and contrast them with parameters of HF severity...
April 1, 2018: Clinical Cardiology
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