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PASK AND Glp-1

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https://www.readbyqxmd.com/read/24445950/pas-kinase-is-a-nutrient-and-energy-sensor-in-hypothalamic-areas-required-for-the-normal-function-of-ampk-and-mtor-s6k1
#1
VerĂ³nica Hurtado-Carneiro, Isabel Roncero, Sascha S Egger, Roland H Wenger, Enrique Blazquez, Carmen Sanz, Elvira Alvarez
The complications caused by overweight, obesity and type 2 diabetes are one of the main problems that increase morbidity and mortality in developed countries. Hypothalamic metabolic sensors play an important role in the control of feeding and energy homeostasis. PAS kinase (PASK) is a nutrient sensor proposed as a regulator of glucose metabolism and cellular energy. The role of PASK might be similar to other known metabolic sensors, such as AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR)...
October 2014: Molecular Neurobiology
https://www.readbyqxmd.com/read/23765195/pas-kinase-as-a-nutrient-sensor-in-neuroblastoma-and-hypothalamic-cells-required-for-the-normal-expression-and-activity-of-other-cellular-nutrient-and-energy-sensors
#2
VerĂ³nica Hurtado-Carneiro, Isabel Roncero, Enrique Blazquez, Elvira Alvarez, Carmen Sanz
PAS kinase (PASK) is a nutrient sensor that is highly conserved throughout evolution. PASK-deficient mice reveal a metabolic phenotype similar to that described in S6 kinase-1 S6K1-deficient mice that are protected against obesity. Hypothalamic metabolic sensors, such as AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR), play an important role in feeding behavior, the homeostasis of body weight, and energy balance. These sensors respond to changes in nutrient levels in the hypothalamic areas involved in feeding behavior and in neuroblastoma N2A cells, and we have recently reported that those effects are modulated by the anorexigenic peptide glucagon-like peptide-1 (GLP-1)...
December 2013: Molecular Neurobiology
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