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https://www.readbyqxmd.com/read/27889121/increasing-estrus-expression-in-the-lactating-dairy-cow
#1
J A Sauls, B E Voelz, S L Hill, L G D Mendonça, J S Stevenson
Using an activity monitoring system (AMS) equipped with an accelerometer, 2 experiments were conducted to test the hypotheses that (1) enhancing progesterone before inducing luteolysis or (2) exposing cows to estradiol cypionate (ECP) or testosterone propionate (TP) after luteolysis would increase occurrence and intensity of estrus. Our goal was to determine if more cows could be detected in estrus by an AMS compared with other estrus-detection aids. In experiment 1, cows (n = 154) were fitted with both an AMS collar and a pressure-sensitive, rump-mounted device (HeatWatch; HW) and assigned to 3 treatments: (1) no CL + progesterone insert (CIDR) for 5 d, (2) CL only, or (3) CL + 2 CIDR inserts for 5 d to achieve a range in concentrations of progesterone...
November 23, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27714952/detection-of-5%C3%AE-androst-2-en-17-one-and-variants-identification-of-main-urinary-metabolites-in-human-urine-samples-by-gc-ms-and-nmr
#2
Christiane Ayotte, Alexandre Sylvestre, Alain Charlebois, Donald Poirier
Two steroids were identified in a supplement named D-2 following the detection of unknown compounds during the routine testing of an athlete's sample. The main glucuroconjugated metabolites were isolated from this urine by high performance liquid chromatography (HPLC) following enzymatic hydrolysis and identified by gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) analyses as being 2α-hydroxy-5α-androst-3-en-17-one (M1) and 2β,3α-dihydroxy-5α-androstan-17-one (M2). A third metabolite, 3α,4β-dihydroxy-5α-androstan-17-one (M3) was also detected, however in lower amounts...
November 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27568044/progesterone-based-fixed-time-artificial-insemination-protocols-for-dairy-cows-gonadotropin-releasing-hormone-versus-estradiol-benzoate-at-initiation-and-estradiol-cypionate-versus-estradiol-benzoate-at-the-end
#3
L F Melo, P L J Monteiro, R S Surjus, J N Drum, M C Wiltbank, R Sartori
Our objectives were to evaluate ovarian dynamics and fertility comparing 2 treatments at the start of a progesterone (P4)-based fixed-time artificial insemination (FTAI) protocol and 2 treatments at the end of the protocol. Thus, 1,035 lactating Holstein cows were assigned in a random phase of the estrous cycle to 1 of 4 treatments using a completely randomized design with a 2 × 2 factorial arrangement. At the beginning of the protocol (d -10), cows received GnRH or estradiol benzoate (EB) and, at the end, EB (d -1) or estradiol cypionate (ECP; d -2), resulting in 4 treatments: GnRH-EB, GnRH-ECP, EB-EB, and EB-ECP...
August 24, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27543363/ovulation-time-in-suckled-beef-cows-is-anticipated-by-use-of-low-doses-of-progesterone-and-temporary-calf-removal-on-fixed-timed-ai-protocol
#4
E R Carvalho, T Martins, G C Lamb, J L M Vasconcelos
This study was designed to evaluate the effect of concentrations of P4 during a fixed-time artificial insemination (TAI) protocol and 48 hours temporary calf removal (CR; i.e., calves were temporally weaned for 48 hours) or treatment with 300 IU of eCG on ovulation time in suckled beef cows. One hundred and fourteen Nellore cows were estrous synchronized by receiving an intravaginal P4 releasing device containing 1.9 g of P4 (CIDR) plus 2.0-mg estradiol benzoate on Day 0, 12.5-mg dinoprost tromethamine on Day 7, and CIDR removal plus 0...
July 25, 2016: Theriogenology
https://www.readbyqxmd.com/read/27536705/four-thrombotic-events-over-5-years-two-pulmonary-emboli-and-two-deep-venous-thrombosis-when-testosterone-hcg-therapy-was-continued-despite-concurrent-anticoagulation-in-a-55-year-old-man-with-lupus-anticoagulant
#5
Charles J Glueck, Kevin Lee, Marloe Prince, Vybhav Jetty, Parth Shah, Ping Wang
BACKGROUND: When exogenous testosterone or treatments to elevate testosterone (human chorionic gonadotropin [HCG] or Clomid) are prescribed for men who have antecedent thrombophilia, deep venous thrombosis and pulmonary embolism often occur and may recur despite adequate anticoagulation if testosterone therapy is continued. CASE PRESENTATION: A 55-year-old white male was referred to us because of 4 thrombotic events, 3 despite adequate anticoagulation over a 5-year period...
July 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/27474237/comparison-of-two-timed-artificial-insemination-system-schemes-to-synchronize-estrus-and-ovulation-in-nellore-cattle
#6
Marcos V C Ferraz Junior, Alexandre V Pires, Marcos V Biehl, Marcelo H Santos, José P R Barroso, José R S Gonçalves, Roberto Sartori, Michael L Day
The aim of this study was to evaluate the reproductive performance of 411 Nellore cows (198 nulliparous, 80 primiparous, and 133 multiparous) submitted to the 5dCO-Synch + P4 or 7dEB + P4 systems. The 5dCO-Synch + P4 system consisted of insertion of an intravaginal progesterone (P4) insert and 100 μg of GnRH (intramuscularly [i.m.]) on Day 0. On Day 5, the P4 insert was removed, and two doses of 25 mg of PGF2α (i.m.) were administered 6 hours apart. Cows not detected in estrus until 55 hours after insert removal received 100 μg of GnRH i...
November 2016: Theriogenology
https://www.readbyqxmd.com/read/27411960/effect-of-estradiol-cypionate-and-gnrh-treatment-on-plasma-estradiol-17%C3%AE-concentrations-synchronization-of-ovulation-and-on-pregnancy-rates-in-suckled-beef-cows-treated-with-ftai-based-protocols
#7
G Uslenghi, A Vater, S Rodríguez Aguilar, J Cabodevila, S Callejas
Two experiments were conducted to evaluate the effect of different ovulation inducers on E-17β plasma concentrations, synchronized ovulations and pregnancy rates. In Experiment 1, cows received a progesterone intravaginal device (PID) with 1 g of progesterone (P4) plus 2 mg of estradiol benzoate (EB) (day 0). At PID removal (day 8), cows received 0.150 mg of D-cloprostenol and were randomly assigned to four treatment groups (n = 10/treatment): Group ECP: 1 mg of estradiol cypionate at PID removal, Group EB: 1 mg of EB 24 hr after PID removal, Group GnRH: 10 μg of GnRH 48 hr after PID removal, Group ECP-GnRH: 1 mg of ECP at PID removal plus 10 μg of GnRH 48 hr later...
October 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27338150/bipolar-androgen-therapy-for-men-with-androgen-ablation-na%C3%A3-ve-prostate-cancer-results-from-the-phase-ii-batman-study
#8
Michael T Schweizer, Hao Wang, Brandon Luber, Rosa Nadal, Avery Spitz, D Marc Rosen, Haiyi Cao, Emmanuel S Antonarakis, Mario A Eisenberger, Michael A Carducci, Channing Paller, Samuel R Denmeade
BACKGROUND: We have previously documented a paradoxical anti-tumor effect when castration-resistant prostate cancer patients were treated with intermittent, high-dose testosterone (i.e., Bipolar Androgen Therapy; BAT). Because, an adaptive increase in androgen receptor expression following chronic androgen deprivation therapy (ADT) may underlie this effect, we tested whether men with hormone-sensitive (HS) prostate cancer (PC) would also respond to BAT if given following a 6-month ADT lead-in...
September 2016: Prostate
https://www.readbyqxmd.com/read/27141449/beyond-testosterone-cypionate-evidence-behind-the-use-of-nandrolone-in-male-health-and-wellness
#9
REVIEW
Michael M Pan, Jason R Kovac
Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medications have. The goal of this review is to highlight an anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) and illustrate prospective therapeutic applications for male health...
April 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/26944539/extending-the-duration-of-treatment-with-progesterone-and-equine-chorionic-gonadotropin-improves-fertility-in-suckled-beef-cows-with-low-body-condition-score-subjected-to-timed-artificial-insemination
#10
M G Bilbao, N Massara, S Ramos, L O Zapata, M F Farcey, J Pesoa, E Turic, M I Vázquez, J A Bartolome
The objective of this study was to evaluate the effect of an extended progesterone treatment on follicular development and fertility in postpartum, suckled beef cows subjected to timed artificial insemination (TAI). In experiment 1, cows (n = 24) with body condition score (BCS) ≥4.5 received either a 2-g progesterone intravaginal device on Day -23 or a 0.558-g progesterone intravaginal device on Day -9. Then, all cows received 2 mg of estradiol benzoate on Day -9; removal of the device, 1-mg estradiol cypionate, and PGF2α on Day -2; and TAI on Day 0...
July 15, 2016: Theriogenology
https://www.readbyqxmd.com/read/26909674/reversal-learning-in-gonadectomized-marmosets-with-and-without-hormone-replacement-are-males-more-sensitive-to-punishment
#11
Matthew LaClair, Agnès Lacreuse
This study examined sex differences in executive function in middle-aged gonadectomized marmosets (Callithrix jacchus) with or without hormonal replacement. We tested ten castrated male (mean age 5.5 years) marmosets treated with testosterone cypionate (T, n = 5) or vehicle (n = 5) on Reversal Learning, which contributes to cognitive flexibility, and the Delayed Response task, measuring working memory. Their performance was compared to that of 11 ovariectomized females (mean age = 3.7 years) treated with Silastic capsules filled with 17-β estradiol (E2, n = 6) or empty capsules (n = 5), previously tested on the same tasks (Lacreuse et al...
May 2016: Animal Cognition
https://www.readbyqxmd.com/read/26812346/impacts-of-meloxicam-administration-before-temporary-calf-weaning-on-physiological-and-reproductive-responses-of-beef-cows
#12
R F Cooke, R F G Peres, R S Cipriano, T A Guarnieri Filho, R S Marques, M C Rodrigues, R S Carvalho, D W Bohnert, J L M Vasconcelos
The objective of this experiment was to evaluate temperament, physiological, and reproductive variables in beef cows assigned to an estrus synchronization + timed AI protocol including eCG administration, 48-h temporary calf weaning (TCW), or TCW + meloxicam administration. A total of 943 lactating, multiparous, nonpregnant Nelore cows, allocated into 8 groups of approximately 120 cows each, were assigned to the experiment. Groups were maintained in individual pastures and assigned to the following estrus synchronization + timed AI protocol: a 2-mg injection of estradiol benzoate and an intravaginal progesterone-releasing device (CIDR) on d 0, a 12...
January 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/26549492/an-analysis-of-the-influence-of-sex-hormones-on-balb-c-mice-infected-with-plasmodium-berghei
#13
Letícia Nobre Lopes, Felipe Augusto Folha Santos, Louize Caroline Marques Oliveira, Marialva Tereza Ferreira Araujo, Carina Guilhon Sequeira, Rosana Maria Feio Libonati, Ana Maria Revoredo da Silva Ventura
Sex steroids can determine several responses in the clinical evolution of malaria. Seventy Balb-c mice were randomly distributed into 7 groups (10 mice per group): G1 to G6 corresponding to castrated females, castrated females that received estradiol cypionate, uncastrated females, castrated males, castrated males that received intramuscular testosterone decanoate and uncastrated males infected with Plasmodium berghei, and G7, the control group. The mice were evaluated with regard to survival, parasitemia, temperature, body weight, hemoglobin level (anemia) and splenic index...
January 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/26464342/comparative-efficacy-of-exogenous-ecg-and-progesterone-on-endogenous-progesterone-and-pregnancy-in-holstein-cows-submitted-to-timed-artificial-insemination
#14
RANDOMIZED CONTROLLED TRIAL
P C Sampaio, N G Alves, J C Souza, J N S Sales, R J Carvalho, R R Lima, A A Teixeira, G P Nogueira, I J Ascari
The objectives were to evaluate the effects of the administration of either eCG or progesterone (P4) alone or combined on endogenous P4 concentrations and pregnancy per AI in lactating dairy cows. Cows received a P4-releasing intravaginal device (PRID) and estradiol benzoate on D-8. The PRID was removed and a PGF2α injection was given on D-3. An estradiol cypionate was given on D-2 and TAI was performed on D0. On D-2, cows were randomly allocated to treatments in a 2×2 factorial design: Control-saline solution on the D-2 and D+3 (n=104), eCG - 400IU eCG on D-2 (n=93), P4 - 600mg of P4 on D+3 (n=106), and eCG+P4 - 400IU eCG on D-2 and 600mg of P4 on D+3 (n=95)...
November 2015: Animal Reproduction Science
https://www.readbyqxmd.com/read/26403540/inducing-ovulation-with-oestradiol-cypionate-allows-flexibility-in-the-timing-of-insemination-and-removes-the-need-for-gonadotrophin-releasing-hormone-in-timed-ai-protocols-for-dairy-cows
#15
R M Ferreira, H Ayres, L U Gimenes, F P Torres, F A Lima, M B Veras, T G Guida, R V Sala, P S Baruselli
The effects of addition of gonadotrophin-releasing hormone (GnRH) to a progesterone plus oestradiol-based protocol and timing of insemination in Holstein cows treated for timed AI (TAI) were evaluated. Cows (n = 481) received a progesterone device and 2 mg oestradiol benzoate. After 8 days, the device was removed and 25 mg dinoprost was administered. Cows were allocated to one of three (Study 1; n = 57) or four (Study 2; n = 424) groups, accordingly to ovulation inducer alone (Study 1; oestradiol cypionate (EC), GnRH or both) or ovulation inducer (EC alone or combined with GnRH) and timing of insemination (48 or 54 h after device removal; Study 2)...
September 25, 2015: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/26200763/untargeted-metabolomics-in-doping-control-detection-of-new-markers-of-testosterone-misuse-by-ultrahigh-performance-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry
#16
Montse Raro, María Ibáñez, Rubén Gil, Andreu Fabregat, Eva Tudela, Koen Deventer, Rosa Ventura, Jordi Segura, Josep Marcos, Aristotelis Kotronoulas, Jesús Joglar, Magi Farré, Sheng Yang, Yanyi Xing, Peter Van Eenoo, Elena Pitarch, Félix Hernández, Juan Vicente Sancho, Óscar J Pozo
The use of untargeted metabolomics for the discovery of markers is a promising and virtually unexplored tool in the doping control field. Hybrid quadrupole time-of-flight (QTOF) and hybrid quadrupole Orbitrap (Q Exactive) mass spectrometers, coupled to ultrahigh pressure liquid chromatography, are excellent tools for this purpose. In the present work, QTOF and Q Exactive have been used to look for markers for testosterone cypionate misuse by means of untargeted metabolomics. Two different groups of urine samples were analyzed, collected before and after the intramuscular administration of testosterone cypionate...
August 18, 2015: Analytical Chemistry
https://www.readbyqxmd.com/read/26169688/impact-of-progesterone-and-estradiol-treatment-before-the-onset-of-the-breeding-period-on-reproductive-performance-of-bos-indicus-beef-heifers
#17
RANDOMIZED CONTROLLED TRIAL
M F Sá Filho, L F T Nasser, L Penteado, R Prestes, M O Marques, B G Freitas, B M Monteiro, R M Ferreira, L U Gimenes, P S Baruselli
The present aimed to develop a hormonal therapy based on the insertion of a progesterone (P4) insert (PI) during 10 d plus an estradiol injection (E2) at PI removal before the onset of breeding of beef heifers. In Exp. 1, the plasma P4 profile of prepubertal heifers showed that the insertion of a PI or 24 d previously used P4 insert (UPI) sustained plasma P4 above 1 ng/mL for at least the first 7 d of the treatment. In Exp. 2 there was no positive effect of additional estradiol benzoate (EB) administered at the insertion of UPI on the proportion of heifers with a corpus luteum (CL/Treated) 30 d after UPI removal [UPI + EB = 85...
September 2015: Animal Reproduction Science
https://www.readbyqxmd.com/read/26022231/effects-of-preovulatory-estradiol-on-embryo-survival-and-pregnancy-establishment-in-beef-cows
#18
RANDOMIZED CONTROLLED TRIAL
Crystal A Madsen, George A Perry, Christina L Mogck, Russell F Daly, Michael D MacNeil, Thomas W Geary
The role of preovulatory estradiol on post-fertilization embryo survival and pregnancy establishment has not been well characterized in beef cows. We hypothesized that preovulatory estradiol is important for embryo survival and pregnancy establishment in beef cows. Twenty-four ovariectomized multiparous cows were used in a replicated 3×3 Latin Square design. Cows received estradiol cypionate (ECP) 36h, estradiol benzoate (EB) 12h, or no estradiol (CON) before a gonadotropin-releasing hormone (d 0) induced LH surge...
July 2015: Animal Reproduction Science
https://www.readbyqxmd.com/read/25864049/increasing-estradiol-benzoate-pretreatment-with-gonadotropin-releasing-hormone-and-impediments-for-successful-estradiol-based-fixed-time-artificial-insemination-protocols-in-dairy-cattle
#19
P L J Monteiro, M Borsato, F L M Silva, A B Prata, M C Wiltbank, R Sartori
With the objective to optimize fixed-time artificial insemination (FTAI) protocols based on estradiol benzoate (EB) and progesterone (P4), we performed 2 experiments (Exp.) in dairy cows. In Exp. 1 (n=44), we hypothesized that increased EB (EB3=3 mg vs. EB2=2 mg) on d 0 would improve synchronization of ovarian follicle wave emergence. Likewise, in Exp. 2 (n=82), we hypothesized that a GnRH treatment on d -3 (early in a follicular wave on d 0) versus d -7 (presence of a dominant follicle on d 0) would better synchronize wave emergence...
June 2015: Journal of Dairy Science
https://www.readbyqxmd.com/read/25733291/androgen-supplementation-in-rats-increases-the-inflammatory-response-and-prolongs-urethral-healing
#20
Matthias D Hofer, Earl Y Cheng, Matthew I Bury, Wei Xu, Seok Jong Hong, William E Kaplan, Arun K Sharma
OBJECTIVE: To describe the effects of androgens on urethral wound healing, we compared the urethral healing process in castrated Sprague-Dawley rats with and without testosterone supplementation. METHODS: Of 30 castrated male Sprague-Dawley rats, 15 received testosterone cypionate (3 mg/kg; T+ rats). All rats underwent an urethroplasty procedure and were sacrificed at postoperative days 5, 10, and 20. Neutrophils, macrophages, vessels, myofibroblasts, Ki67+ cells, collagen, and cytokines were quantified with immunofluorescence and real-time polymerase chain reaction...
March 2015: Urology
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