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https://www.readbyqxmd.com/read/29771451/modulation-of-inflammatory-and-hormonal-parameters-in-response-to-testosterone-therapy-effects-on-the-ventral-prostate-of-adult-rats
#1
Leonardo O Mendes, Anthony C S Castilho, Cristiane F Pinho, Bianca F Gonçalvez, Eduardo M Razza, Luiz Gustavo A Chuffa, Janete A Anselmo-Franci, Wellerson R Scarano, Francisco E Martinez
Testosterone is often recommended in the treatment of several aging-related conditions. However, there are still questions about the consequences of this therapy in terms of hormonal and inflammatory parameters that are crucial for prostate homeostasis.Thus, we investigate if the testosterone therapy (TT) modulates the hormone receptors and inflammatory cytokines in the ventral prostate of adult rats. Wistar rats aging 150 days were divided into two experimental groups(n = 10/group): T: received subcutaneous injections of testosterone cypionate (5mg/kg body weight) diluted in corn oil every other day for 4 weeks; and C: received corn oil as vehicle...
May 17, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29704577/food-drug-interaction-anabolic-steroids-aggravate-hepatic-lipotoxicity-and-nonalcoholic-fatty-liver-disease-induced-by-trans-fatty-acids
#2
Jamili D B Santos, Andrea A S Mendonça, Rafaela C Sousa, Thaiany G S Silva, Solange M Bigonha, Eliziária C Santos, Reggiani V Gonçalves, Romulo D Novaes
Remains unknown if dietary lipids and anabolic steroids (AS) can interact to modify energy metabolism, hepatic structure and function. We investigated the impact of AS on gene expression, lipid profile, redox status and the development of nonalcoholic fatty liver disease (NAFLD) in mice treated with a diet rich in trans fatty acids. Seventy-two C57BL/6 mice were equally randomized into six groups and treated with a standard diet (SD) or high-fat diet (HFD) alone or combined with testosterone cypionate (10 or 20 mg/kg) for 12 weeks...
April 25, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29653388/synchronization-treatments-previous-to-natural-breeding-anticipate-and-improve-the-pregnancy-rate-of-postpartum-primiparous-beef-cows
#3
R M Ferreira, T L Conti, R L Gonçalves, L A Souto, J N S Sales, M F Sá Filho, F M Elliff, P S Baruselli
Timed AI has become a potential tool to bypass postpartum acyclicity, yet only a small percentage of the world bovine herd is inseminated. Most females are still subjected to bull mating; therefore, the frequent occurrence of postpartum anestrus may compromise their reproductive efficiency. Thus, the aim of this study was to develop an approach that allows the early conception of postpartum primiparous beef cows that are exposed to natural breeding (NB). For this purpose, 350 primiparous Nelore cows 35-65 d postpartum were allocated into three groups: Control (no hormonal treatment), TNB (hormonal protocol for timed-NB without equine chorionic gonadotropin; eCG) and TNB + eCG (hormonal protocol for TNB with eCG) groups...
April 4, 2018: Theriogenology
https://www.readbyqxmd.com/read/29626739/hormonal-strategy-to-reduce-suckled-beef-cow-handling-for-timed-artificial-insemination-with-sex-sorted-semen
#4
M A V Silva, C S Santos, I G França, H G Pereira, M F Sá Filho, B G Freitas, B M Guerreiro, A Faquim, P S Baruselli, J R S Torres-Júnior
Two experiments were conducted to assess a hormonal strategy developed to reduce animal handling for timed artificial insemination (TAI) with sex-sorted semen. Four-hundred ninety-one (491) suckled beef cows received a progesterone (P4) intravaginal device and 2 mg intramuscular (im) injection of estradiol benzoate (EB) on a randomly chosen day of the estrus cycle (Day 0) in Experiment 1. Cows were treated with 500 μg of sodic cloprostenol (PGF2α) and with 300 IU of eCG at P4 device removal (Day 8); these cows were also randomly assigned to receive 1 mg of estradiol cypionate (EC) administered at P4 device removal (treatment EC-0h) or 1 mg of EB 24 h after P4 device removal (treatment EB-24h)...
March 21, 2018: Theriogenology
https://www.readbyqxmd.com/read/29521667/estradiol-suppresses-ingestive-response-evoked-by-activation-of-5-ht1a-receptors-in-the-lateral-hypothalamus-of-ovariectomized-rats
#5
Ana P D Taschetto, Brunno R Levone, Larissa Kochenborger, Eduardo S da Silva, Rafael A Flores, Moacir S Faria, Marta A Paschoalini
The present study investigated the effects of estradiol (E2) on ingestive behavior after activation of 5-HT1A receptors in the lateral hypothalamus (LH) of female rats habituated to eat a wet mash diet. Ovariectomized rats treated with corn oil (OVX) or estradiol cypionate (OVX+E) received local injections into the LH of vehicle or an agonist of 5-HT1A receptors, 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT; at a dose of 6 nmol). To determine the involvement of these receptors in food intake, some animals were pretreated with N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide maleate (WAY-100635, a 5-HT1A receptor full antagonist, at a dose of 0...
March 8, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29510085/anabolic-effects-of-chrysin-on-the-ventral-male-prostate-and-female-prostate-of-adult-gerbils-meriones-unguiculatus
#6
Mônica S Campos, Naiara C S Ribeiro, Rodrigo F de Lima, Mariana B Santos, Patrícia S L Vilamaior, Luis O Regasini, Manoel F Biancardi, Sebastião R Taboga, Fernanda C A Santos
Chrysin is a bioflavonoid found in fruits, flowers, tea, honey and wine, which has antioxidant, anti-inflammatory, antiallergic and anticarcinogenic properties. This flavone has also been considered as beneficial for reproduction due its testosterone-boosting potential. Thus, the aim of this study was to evaluate the effects of chrysin on the prostate and gonads of male and female adult gerbils. In addition, a comparative analysis of the effects of testosterone on these same organs was conducted. Ninety-day-old male and female gerbils were treated with chrysin (50mgkg-1day-1) or testosterone cypionate (1mgkg-1week-1) for 21 days...
March 7, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29469650/prenatal-androgen-exposure-causes-hypertension-and-gut-microbiota-dysbiosis
#7
Shermel Sherman, Nadeen Sarsour, Marziyeh Salehi, Allen Schroering, Blair Mell, Bina Joe, Jennifer W Hill
BACKGROUND: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant...
February 22, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29436172/population-pharmacokinetic-pharmacodynamic-modeling-of-depot-testosterone-cypionate-in-healthy-male-subjects
#8
Youwei Bi, Paul J Perry, Michael Ellerby, Daryl J Murry
A randomized, double-blind clinical trial was conducted to investigate long-term abuse effects of testosterone cypionate (TC). Thirty-one healthy men were randomized into a dose group of 100, 250, or 500 mg/wk and received 14 weekly injections of TC. A pharmacokinetic/pharmacodynamic (PK/PD) model was developed to characterize testosterone concentrations and link exposure to change in luteinizing hormone and spermatogenesis following long-term TC administration. A linear one-compartment model best described the concentration-time profile of total testosterone...
April 2018: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29428845/decreasing-from-9-to-7-days-the-permanence-of-progesterone-inserts-make-possible-their-use-up-to-5-folds-in-suckled-nellore-cows
#9
Marcelo H Santos, Marcos Vinicius C Ferraz Junior, Daniel M Polizel, José Paulo R Barroso, Alexandre A Miszura, André S Martins, Analisa V Bertoloni, Gabriela B Oliveira, Alexandre V Pires
This study aimed to evaluate the effects of decreasing permanence period of progesterone (P4) inserts from 9 (9d) to 7 (7d) days in timed-AI (TAI) protocol, as well as their reuse on pregnancy per AI (P/AI) during 7d protocol. At the beginning of all protocols, cows received 2 mg of estradiol benzoate (EB) and a vaginal insert containing 1.9 g of P4. In the 7d protocol, the P4 insert was removed, and cows were given 25 mg of prostaglandin F2α, 0.6 mg of estradiol cypionate and 300 IU of eCG 7 days later...
April 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29428844/effect-of-different-chorionic-gonadotropins-on-final-growth-of-the-dominant-follicle-in-bos-indicus-cows
#10
Alexandre B Prata, Jéssica N Drum, Leonardo F Melo, Estela R Araujo, Roberto Sartori
The aim of this study was to evaluate the effect of eCG or hCG on the final growth of the dominant follicle in Nelore (Bos indicus) cows submitted to fixed-time AI (FTAI). Eighty-four lactating cows with body condition score (BCS) of 2.9 (range 1-5) were used. At a random day of the estrous cycle (D0) cows received 2 mg estradiol benzoate and a reused intravaginal progesterone device (1.9 g). At D8, when the device was removed, 0.5 mg cloprostenol and 1 mg estradiol cypionate was given i.m., and cows were randomly assigned to receive on D8 one of the following treatments: Control (no treatment; n = 17), eCG (300 IU i...
April 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29428754/follicular-dynamics-circulating-progesterone-and-fertility-in-holstein-cows-synchronized-with-reused-intravaginal-progesterone-implants-that-were-sanitized-by-autoclave-or-chemical-disinfection
#11
L F Melo, P L J Monteiro, A B Nascimento, J N Drum, C Spies, A B Prata, M C Wiltbank, R Sartori
This experiment aimed to compare circulating progesterone (P4), follicular dynamics, and fertility during reuse of intravaginal P4 implants that were sanitized by autoclave or chemical disinfection in lactating Holstein cows submitted to fixed-time artificial insemination (FTAI). For this, 123 primiparous and 226 multiparous cows from 2 farms, averaging (mean ± standard deviation) 163.9 ± 141.9 d in milk, 35.7 ± 11.3 kg of milk/d, and a body condition score of 2.9 ± 0.5, were enrolled in the study. Cows were randomly assigned to 1 of 2 treatments using a completely randomized design and each cow received a reused implant (1...
April 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29408965/impacts-of-estrus-expression-and-intensity-during-a-timed-ai-protocol-on-variables-associated-with-fertility-and-pregnancy-success-in-bos-indicus-influenced-beef-cows
#12
A D Rodrigues, R F Cooke, R S Cipriano, L G T Silva, R L A Cerri, L H Cruppe, M Meneghetti, K G Pohler, J L M Vasconcelos
This experiment evaluated the impacts of estrus expression and intensity, estimated by physical activity during a timed-AI protocol, on reproductive performance of Bos indicus-influenced beef cows. A total of 290 lactating, primiparous, and multiparous nonpregnant Nelore × Angus cows received a 2 mg injection of estradiol benzoate and an intravaginal progesterone (P4) releasing device (CIDR) on d -11, a 12.5 mg injection of PGF2α on d -4, CIDR removal in addition to 0.6 mg injection of estradiol cypionate and 300 IU injection of eCG on d -2, and timed-AI on d 0...
February 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29367424/pharmacokinetics-safety-and-patient-acceptability-of-subcutaneous-versus-intramuscular-testosterone-injection-for-gender-affirming-therapy-a-pilot-study
#13
David M Wilson, Tony K L Kiang, Mary H H Ensom
PURPOSE: Results of a study comparing testosterone exposure and tolerability with subcutaneous versus i.m. administration are presented. METHODS: In a prospective, open-label, crossover study, adult participants already on stable i.m. testosterone gender-affirming therapy self-injected testosterone cypionate or enanthate i.m. for 3 weeks followed by subcutaneous injections for 8 weeks. Trough serum testosterone concentrations were determined weekly, and serial total serum testosterone (TST) concentrations were determined on postinjection days 1, 3, and 5 of weeks 3 and 11...
January 24, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29166551/evaluation-of-markers-out-of-the-steroid-profile-for-the-screening-of-testosterone-misuse-part-ii-intramuscular-administration
#14
Aristotelis Kotronoulas, Àlex Gomez-Gómez, Andreu Fabregat, Jordi Segura, Sheng Yang, Yanyi Xing, Wu Moutian, Josep Marcos, Jesús Joglar, Rosa Ventura, Oscar J Pozo
In the fight against doping, the introduction of alternative markers to the steroid profile can be considered as an effective approach to improve the screening capabilities for the detection of testosterone (T) misuse. The aim of this study was to evaluate the potential of several T metabolites (cysteinyl conjugated and glucuronoconjugated resistant to enzymatic hydrolysis) to detect both the transdermal and the intramuscular administration of T. In Part I of the study, we studied the potential of these metabolites for the detection of T transdermal administration...
November 22, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29132837/prepubertal-chrysin-exposure-upregulates-either-ar-in-male-ventral-prostate-or-ar-and-er%C3%AE-in-skene-s-paraurethral-gland-of-pubertal-and-adult-gerbils
#15
Naiara C S Ribeiro, Mônica S Campos, Mariana B Santos, Gabriela M Ayusso, Patrícia S L Vilamaior, Luis O Regasini, Sebastião R Taboga, Manoel F Biancardi, Ana P S Perez, Fernanda C A Santos
Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone...
January 2018: Fitoterapia
https://www.readbyqxmd.com/read/29118976/impact-of-hormonal-modulation-at-proestrus-on-ovarian-responses-and-uterine-gene-expression-of-suckled-anestrous-beef-cows
#16
Manoel Francisco de Sá Filho, Angela Maria Gonella-Diaza, Mariana Sponchiado, Marcio Ferreira Mendanha, Guilherme Pugliesi, Roney Dos Santos Ramos, Sónia Cristina da Silva Andrade, Gustavo Gasparin, Luiz Lehmann Coutinho, Marcelo Demarchi Goissis, Fernando Silveira Mesquita, Pietro Sampaio Baruselli, Mario Binelli
Background: This study evaluated the impact of hormonal modulation at the onset of proestrus on ovarian response and uterine gene expression of beef cows. Methods: A total of 172 anestrous beef cows were assigned to one of four groups according to the treatment with estradiol cypionate (ECP) and/or equine chorionic gonadotropin (eCG) [CON ( n  = 43), ECP (n = 43), eCG ( n  = 44) and ECP + eCG ( n  = 42)]. Results: ECP-treated cows (ECP and ECP + eCG groups) presented greater occurrence of estrus (44...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28846912/impact-of-estradiol-cypionate-prior-to-tai-and-progesterone-supplementation-at-initial-diestrus-on-ovarian-and-fertility-responses-in-beef-cows
#17
T Martins, J P Talamoni, M Sponchiado, J R G Maio, G P Nogueira, G Pugliesi, M Binelli
In cattle, early diestrus progesterone (P4) supplementation modulates endometrial function to exert pro- and anti-pregnancy establishment effects; specifically, P4 stimulates conceptus growth, but also induces early onset of luteolysis. This paradoxical effect is frequently related to the inconsistent fertility outcomes that result from P4 supplementation experiments. Aim was to investigate the impact of exogenous estradiol (E2) treatment at the end of timed fixed AI (TAI) on frequency of early luteolysis and pregnancy of beef cows supplemented with P4...
August 19, 2017: Theriogenology
https://www.readbyqxmd.com/read/28792796/clinical-response-and-side-effects-associated-with-testosterone-cypionate-for-urinary-incontinence-in-male-dogs
#18
Jean-Sébastien Palerme, Allison Mazepa, Rae G Hutchins, Vincent Ziglioli, Shelly L Vaden
Urethral sphincter mechanism incompetence (USMI) is reported much more seldom in male dogs than in female dogs. The few existing reports evaluating the efficacy of medical therapy in controlling USMI in males have demonstrated limited success. In this case series, we report the effect of testosterone cypionate, given at a median dose of 1.5 mg/kg intramuscularly every 4 wk, in eight male dogs with USMI. Response was evaluated through the review of medical records and telephone interviews with the clients. Based on owners' assessments, a good to excellent response was reported in three of eight dogs (38%), a slight response was reported in one of eight dogs (12%), and a poor response was reported in four of eight dogs (50%)...
August 9, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28780109/comparison-of-2-protocols-to-increase-circulating-progesterone-concentration-before-timed-artificial-insemination-in-lactating-dairy-cows-with-or-without-elevated-body-temperature
#19
M H C Pereira, M C Wiltbank, T G Guida, F R Lopes, J L M Vasconcelos
Two treatments designed to increase circulating progesterone concentration (P4) during preovulatory follicle development were compared. One treatment used 2 intravaginal P4 implants (controlled internal drug-releasing inserts; CIDR) and the other used a GnRH treatment at beginning of the protocol. Lactating Holstein cows that had been diagnosed as nonpregnant were randomly assigned to receive timed artificial insemination (TAI) following 1 of 2 treatments (n = 1,638 breedings): (1) GnRH: CIDR+ 2 mg of estradiol (E2) benzoate + 100 µg of GnRH on d -11, PGF2α on d -4, CIDR withdrawal + 1...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28755579/estradiol-cypionate-aided-treatment-for-experimentally-induced-ascending-placentitis-in-mares
#20
Bruna R Curcio, Igor F Canisso, Fernanda M Pazinato, Luciana A Borba, Lorena S Feijó, Vitoria Muller, Ilusca S Finger, Ramiro E Toribio, Carlos E W Nogueira
The overall goal of this study was to assess the efficacy of various therapeutic combinations of estradiol cypionate (ECP, a long-acting estrogen) and altrenogest (ALT, a long-acting progestin) in addition to basic treatment for placentitis with trimethoprim-sulfamethoxazole (TMS) and flunixin meglumine (FM). Specific outcomes measured in this experiment were (i) time from induction of bacterial placentitis to delivery, and foal parameters (high-risk, survival, and birth weight); and (ii) serum steroid concentrations (progesterone, 17α-hydroxyprogesterone, 17β-estradiol, and cortisol) in response to treatment...
October 15, 2017: Theriogenology
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