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https://www.readbyqxmd.com/read/29775676/malondialdehyde-modified-ldl-related-variables-are-associated-with-diabetic-kidney-disease-in-type-2-diabetes
#1
Shoko Furukawa, Hiroaki Suzuki, Kazuya Fujihara, Kazuto Kobayashi, Hitoshi Iwasaki, Yoko Sugano, Shigeru Yatoh, Motohiro Sekiya, Naoya Yahagi, Hitoshi Shimano
BACKGROUND AND AIMS: Oxidized low-density lipoprotein (oxLDL) causes the development of atherosclerosis and kidney injury. Although circulating oxLDL levels were reportedly increased in type 2 diabetic patients with macroalbuminuria, it remains unclear whether albuminuria or the reduced glomerular filtration rate (GFR) is independently associated with the circulating oxLDL level. This study aimed to elucidate the association between the stage of diabetic nephropathy and serum malondialdehyde-modified LDL (MDA-LDL) and the ratio of MDA-LDL to LDL-cholesterol (MDA-LDL/LDL)...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29772531/effects-of-oxidized-lipids-and-lipoproteins-on-cardiac-function
#2
Tahar Hajri
Oxidative modifications of lipids and lipoproteins have long been linked to the pathogenesis of cardiovascular diseases including atherosclerosis and coronary disease. Furthermore, overwhelming evidence indicate that oxidized lipids are also associated with myocardial dysfunction and cardiomyopathy. Oxidized lipid derivatives are generated by enzymatic and non-enzymatic reactions with unsaturated lipids in the cell and foods. In addition, blood LDL particles are prone to oxidation leading to the formation of oxidized LDL (oxLDL), which is often associated with obesity, diabetes and metabolic disease...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29766292/gut-derived-lipopolysaccharides-increase-post-prandial-oxidative-stress-via-nox2-activation-in-patients-with-impaired-fasting-glucose-tolerance-effect-of-extra-virgin-olive-oil
#3
Roberto Carnevale, Daniele Pastori, Cristina Nocella, Vittoria Cammisotto, Simona Bartimoccia, Marta Novo, Maria Del Ben, Alessio Farcomeni, Francesco Angelico, Francesco Violi
PURPOSE: Post-prandial phase is characterized by enhanced oxidative stress but the underlying mechanism is unclear. We investigated if gut-derived lipopolysaccharide (LPS) is implicated in this phenomenon and the effect of extra virgin olive oil (EVOO) in patients with impaired fasting glucose (IFG). METHODS: This is a randomized cross-over interventional study including 30 IFG patients, to receive a lunch with or without 10 g of EVOO. Serum LPS, Apo-B48, markers of oxidative stress such as oxidized LDL (oxLDL) and soluble Nox2-derived peptide (sNox2-dp), a marker of nicotinamide-adenine-dinucleotide-phosphate oxidase isoform Nox2 activation, and plasma polyphenols were determined before, 60 and 120 min after lunch...
May 16, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29742249/oxldl-plasma-levels-in-patients-with-alzheimer-s-disease
#4
Marina Felipe Grossi, Maria das Graças Carvalho, Josianne Nicácio Silveira, Gisele Santos Gonçalves, Karina Braga Gomes, Maria Aparecida Bicalho, Ieda de Fátima Oliveira Silva
OBJECTIVE: The objective of this study was to characterize the conventional lipid profile, oxLDL levels and ApoE polymorphism in patients with Alzheimer's disease (AD) and in elderly individuals without cognitive impairment. METHODS: Eighty elderly individuals were selected and the levels of oxLDL were determined using the ELISA kit, and ApoE gene polymorphism was investigated using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Significantly reduced levels of oxLDL were observed in patients with AD compared to the control group...
April 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29704538/in-vitro-oxidized-hdl-and-hdl-from-type-2-diabetes-patients-have-reduced-ability-to-efflux-oxysterols-from-thp-1-macrophages
#5
Yinan Chena, Maud Arnal-Levron, Françoise Hullin-Matsuda, Carole Knibbe, Philippe Moulin, Céline Luquain-Costaz, Isabelle Delton
Oxidized LDL (OxLDL) that are enriched in products of lipid peroxidation including oxysterols have been shown to induce cellular oxidative stress and cytotoxicity therefore accelerating atheroma plaque formation. Upon oxLDL exposure of THP-1 macrophages, intracellular oxidation of LDL derived-cholesterol as well as endogenous cholesterol was increased. The oxysterols intracellularly produced were efficiently exported to HDL whereas apolipoprotein A1 was inefficient. These findings prompted us to investigate the consequences of modification of HDL by oxidation and glycation as observed in type 2 diabetes with respect to oxysterol and cholesterol efflux...
April 26, 2018: Biochimie
https://www.readbyqxmd.com/read/29703160/shp2-inhibitor-phps1-protects-against-atherosclerosis-by-inhibiting-smooth-muscle-cell-proliferation
#6
Jia Chen, Zhiyong Cao, Jingshu Guan
BACKGROUND: Smooth muscle cells play an important role in the development of atherosclerosis. SHP2 is known to regulate the proliferation and migration of smooth muscle cells. The purpose of this study was to determine whether the SHP2 inhibitor PHPS1 has a pro-atherosclerotic or an atheroprotective effect in vivo and in vitro. METHODS: After exposure to a high-cholesterol diet for 4 weeks, LDL receptor-deficient (Ldlr-/- ) mice were exposed to the SHP2 inhibitor PHPS1 or vehicle...
April 27, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29682152/thrombomodulin-as-a-new-marker-of-endothelial-dysfunction-in-chronic-kidney-disease-in-children
#7
Dorota Drożdż, Monika Łątka, Tomasz Drożdż, Krystyna Sztefko, Przemko Kwinta
Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29664028/dyslipidaemia-oxidative-stress-in-patients-of-psoriasis-emerging-cardiovascular-risk-factors
#8
Kumari Asha, Archana Singal, Suman Bala Sharma, Vinod Kumar Arora, Amitesh Aggarwal
Background & objectives: Psoriasis is a recurrent hyper-proliferative skin disease which is often associated with free radical generation, abnormal lipid metabolism and increased inflammatory secretion that induce cardiovascular risk in these patients. The present study was intended to evaluate serum lipids, lipoprotein and oxidants-antioxidants status and to establish their relationship with atherogenic risk markers [oxidized low-density lipoprotein (oxLDL) and high-sensitivity C-reactive protein (hsCRP)] in patients with psoriasis...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29656494/oxidized-ldl-phagocytosis-during-foam-cell-formation-in-atherosclerotic-plaques-relies-on-a-pld2-cd36-functional-interdependence
#9
Ramya Ganesan, Karen M Henkels, Lucile E Wrenshall, Yasunori Kanaho, Gilbert Di Paolo, Michael A Frohman, Julian Gomez-Cambronero
The uptake of cholesterol carried by low-density lipoprotein (LDL) is tightly controlled in the body. Macrophages are not well suited to counteract the cellular consequences of excess cholesterol leading to their transformation into "foam cells," an early step in vascular plaque formation. We have uncovered and characterized a novel mechanism involving phospholipase D (PLD) in foam cell formation. Utilizing bone marrow-derived macrophages from genetically PLD deficient mice, we demonstrate that PLD2 (but not PLD1)-null macrophages cannot fully phagocytose aggregated oxidized LDL (Agg-Ox-LDL), which was phenocopied with a PLD2-selective inhibitor...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29619884/cardioprotective-effect-of-%C3%AE-d-mannuronic-acid-m2000-as-a-novel-nsaid-on-gene-expression-of-oxldl-scavenger-receptors-in-the-experimental-diabetic-model
#10
Seyed Shahabeddin Mortazavi-Jahromi, Shahab Alizadeh, Mohammad Hassan Javanbakht, Abbas Mirshafiey
CONTEXT: The investigations have shown that patients with diabetes have the elevated levels of glucose and oxLDL. These two play an important role in increased expression levels of oxLDL scavenger receptors on the surface of macrophages and endothelial cells that leads to deposition of oxLDL and macrophages in vascular walls. OBJECTIVE: The present study intends to show the effects of β-d-mannuronic acid (M2000) on the expression profile of ox-LDL scavenger receptors (including SR-A, LOX-1, CD36, and CD68) in an experimental model of diabetes...
April 5, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29617044/pcsk9-plays-a-novel-immunological-role-in-the-oxidized-ldl-induced-dendritic-cell-maturation-and-t-cell-activation-from-human-blood-and-atherosclerotic-plaque
#11
Anquan Liu, Johan Frostegård
BACKGROUND: Activated T cells and dendritic cells (DCs) occur in atherosclerotic plaques. Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR), and results in increased LDL-levels. We here investigate immune effects of PCSK9 on OxLDL induced DC maturation and T cell activation. METHODS: T cells were isolated from carotid specimens of patients undergoing carotid endarterectomy, or from peripheral blood of healthy individuals. Human peripheral blood monocytes were differentiated into DCs...
April 4, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29572081/ldl-oxidation-serum-uric-acid-kidney-function-and-pulse-wave-velocity-data-from-the-brisighella-heart-study-cohort
#12
Arrigo F G Cicero, Masanari Kuwabara, Richard Johnson, Marilisa Bove, Federica Fogacci, Martina Rosticci, Marina Giovannini, Sergio D'Addato, Claudio Borghi
BACKGROUND: Serum uric acid (SUA) and oxidized LDL (oxLDL) may be associated with arterial aging. The aim of our study was to evaluate the relationship between SUA, oxLDL and arterial stiffness in subjects with normal renal function and in patients with mild or moderate renal impairment. METHODS: From the database of the 2012 Brisighella Heart Study, we compared age-matched adult, non-smoker subjects without cardiovascular disease and with normal renal function (n = 205), subjects with stage II chronic kidney disease (CKD) (n = 118) and subjects with stage III CKD (n = 94)...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29522752/rna-helicase-ddx5-participates-in-oxldl-induced-macrophage-scavenger-receptor-1-expression-by-suppressing-mrna-degradation
#13
Wenting Zhao, Zhen Wang, Zewei Sun, Yuxian He, Dongdong Jian, Xiaotong Hu, Wang Zhang, Liangrong Zheng
The DEAD box protein DDX5, an ATP-dependent RNA helicase, plays an important role in transcriptional regulation and is associated with solid tumors and leukemia. However, its role in oxLDL-induced lipid uptake in macrophages remains unclear. In this study, we detected the expression of DDX5 mRNA and protein in oxidized low-density lipoprotein (oxLDL)-treated human primary macrophages that were induced from monocytes isolated from human peripheral blood with or without several chemical inhibitors using quantitative real-time PCR (qRT-PCR) or Western blotting...
May 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29521196/significance-of-oxidized-low-density-lipoprotein-in-body-fluids-as-a-marker-related-to-diseased-conditions
#14
Hiroyuki Itabe, Rina Kato, Naoko Sasabe, Takashi Obama, Matsuo Yamamoto
Oxidatively modified low-density lipoprotein (oxLDL) is known to be involved in various diseases, including cardiovascular diseases. The presence of oxLDL in the human circulatory system and in atherosclerotic lesions has been demonstrated using monoclonal antibodies. Studies have shown the significance of circulating oxLDL in various systemic diseases, including acute myocardial infarction and diabetic mellitus. Several different enzyme-linked immunosorbent assay (ELISA) procedures to measure oxLDL were utilized...
March 6, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29427237/differential-expression-of-lp-pla2-in-obesity-and-type-2-diabetes-and-the-influence-of-lipids
#15
Laura Jackisch, Warunee Kumsaiyai, Jonathan D Moore, Nasser Al-Daghri, Ioannis Kyrou, Thomas M Barber, Harpal Randeva, Sudhesh Kumar, Gyanendra Tripathi, Philip G McTernan
AIMS/HYPOTHESIS: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a circulatory macrophage-derived factor that increases with obesity and leads to a higher risk of cardiovascular disease (CVD). Despite this, its role in adipose tissue and the adipocyte is unknown. Therefore, the aims of this study were to clarify the expression of Lp-PLA2 in relation to different adipose tissue depots and type 2 diabetes, and ascertain whether markers of obesity and type 2 diabetes correlate with circulating Lp-PLA2...
May 2018: Diabetologia
https://www.readbyqxmd.com/read/29425936/oxidized-low-density-lipoproteins-the-bridge-between-atherosclerosis-and-autoimmunity-possible-implications-in-accelerated-atherosclerosis-and-for-immune-intervention-in-autoimmune-rheumatic-disorders
#16
REVIEW
Claudia Floriana Suciu, Marcella Prete, Piero Ruscitti, Elvira Favoino, Roberto Giacomelli, Federico Perosa
Atherosclerotic vasculopathy is a multifactorial process causing vessels damage and cardiovascular diseases, the leading causes of death worldwide. Atherosclerotic plaque is the asymptomatic primary, elementary, lesion of atherosclerotic vasculopathy. Accumulation of the oxidized low-density lipoprotein (oxLDL) at sub endothelial sites is now recognized as one of the major trigger events in plaque formation. The concomitant presence at the plaque site of cells belonging to either natural or adaptive immunity, the detection of autoantibodies to oxLDL, the cross-reactivity of oxLDL with anti-phospholipid antibodies, in addition to the clinical evidence of increased rates of cardiovascular events in several rheumatic diseases, has stimulated intensive research to define interconnections between the immune system and traditional risk factors at the molecular levels in order to explain accelerated atherosclerosis...
April 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29425557/low-density-lipoprotein-interferes-with-intracellular-signaling-of-monocytes-resulting-in-impaired-chemotaxis-and-enhanced-chemokinesis
#17
Kerstin Tjaden, Christina Adam, Rinesh Godfrey, Peter J Hanley, Evangelia Pardali, Johannes Waltenberger
BACKGROUND: Hypercholesterolemia (HC) is an important cardiovascular risk factor characterized by elevated low density lipoprotein-cholesterol (LDL-C) plasma levels. HC negatively affects monocyte function by reducing their chemotactic response towards different growth factors. We aimed to elucidate the molecular mechanisms by which LDL induces monocyte dysfunction. METHODS AND RESULTS: Human monocytes exposed to either native (nLDL) or oxidized LDL (oxLDL) in vitro showed reduced chemotactic responses towards vascular endothelial growth factor A (VEGFA) and monocyte chemotactic protein-1 (MCP-1), but displayed enhanced random migration (chemokinesis)...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29408168/relationship-between-postprandial-lipemia-and-atherogenic-factors-in-healthy-subjects-by-considering-gender-differences
#18
Asım Orem, Serap Ozer Yaman, Buket Altinkaynak, Birgül Vanizor Kural, Fulya Balaban Yucesan, Yahya Altinkaynak, Cihan Orem
BACKGROUND: Postprandial triglyceride concentrations are clinically significant and independent predictor of cardiovascular disease risk. The purpose of this study was to determine postprandial TG ranges in healthy subjects by considering gender differences. Secondly, assess the relationship between postprandial lipemia and atherogenic indicators. Finally, investigate the use of the postprandial 4h TG test instead of the area under the curve (AUC). METHODS: Postprandial lipemia was investigated using the standardized oral fat tolerance test (OFTT) in 96 healthy subjects (45 female/51 male)...
May 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29399922/ldl-dinitrosyl-iron-complex-a-new-transferrin-independent-route-for-iron-delivery-in-hepatocytes
#19
Hanna Lewandowska, Sylwia Męczyńska-Wielgosz, Katarzyna Sikorska, Jarosław Sadło, Jakub Dudek, Marcin Kruszewski
In view of the interrelations between NO, Fe, and LDL in the cardiovascular system it appears interesting to find out, if the lipoprotein particles undergo the process of iron-nitrosylation, commonly observed for other proteins and what is the biological fate of iron-nitrosylated LDL particles. Iron-nitrosylated LDL preparation containing Fe(NO)2 motif (DNICLDL) was obtained and characterized for the first time. In order to test its interactions with potential target cells, DNICLDL was administered to the hepatoma HepG2 cells...
March 2018: BioFactors
https://www.readbyqxmd.com/read/29383092/identification-of-the-histone-lysine-demethylase-kdm4a-jmjd2a-as-a-novel-epigenetic-target-in-m1-macrophage-polarization-induced-by-oxidized-ldl
#20
Xue Wang, Siqing Wang, Gang Yao, Dehai Yu, Kexin Chen, Qian Tong, Long Ye, Chuan Wu, Yue Sun, Haixia Li, Dirk M Hermann, Thorsten R Doeppner, Fengyan Jin, Yun Dai, Jiang Wu
Oxidized low density lipoprotein (oxLDL) induces macrophage activation, an event essential for atherosclerosis. Emerging evidence supports that epigenetic regulation plays important roles in macrophage activation and function. However, it remains unclear which epigenetic modulator is responsible for oxLDL-induced macrophage activation. Here, we identify for the first time KDM4A (JMJD2A) as an epigenetic modifying enzyme that controls oxLDL-induced pro-inflammatory M1 polarization of macrophages. OxLDL triggered M1 polarization of murine and human macrophages, characterized by expression of iNOS and robust production of inflammatory cytokines (e...
December 29, 2017: Oncotarget
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