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https://www.readbyqxmd.com/read/29334762/altered-redox-state-modulates-endothelial-kca2-3-and-kca3-1-levels-in-normal-pregnancy-and-preeclampsia
#1
Shinkyu Choi, Ji Aee Kim, Hai-Yan Li, Sae-Jin Lee, Ye Seon Seok, Tae Hun Kim, Ki-Hwan Han, Mi Hye Park, Geum Joon Cho, Suk Hyo Suh
AIMS: Altered redox state has been related to the development of normal pregnancy (NP) and preeclampsia (PE). Endothelial KCa2.3 and KCa3.1 (KCas) play an important role in vasodilation, and KCas levels are affected by oxidative stress. We investigated the mechanisms of oxidative stress-mediated KCas expression modulation during NP and PE. RESULTS: Human uterine microvascular endothelial cells were incubated in serum from normal non-pregnant women (n=13) and women with NP (n=24) or PE (n=15), or in VEGF, oxidized low-density lipoprotein (ox-LDL), progesterone, or estradiol-17-containing medium for 24 hours...
January 15, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29329335/immunization-with-gingipain-a-hemagglutinin-domain-of-porphyromonas-gingivalis-induces-igm-antibodies-binding-to-malondialdehyde-acetaldehyde-modified-low-density-lipoprotein
#2
Mikael Kyrklund, Outi Kummu, Jari Kankaanpää, Ramin Akhi, Antti Nissinen, S Pauliina Turunen, Pirkko Pussinen, Chunguang Wang, Sohvi Hörkkö
Treatment of periodontitis has beneficial effects on systemic inflammation markers that relate to progression of atherosclerosis. We aimed to investigate whether immunization with A hemagglutinin domain (Rgp44) of Porphyromonas gingivalis (Pg), a major etiologic agent of periodontitis, would lead to an antibody response cross-reacting with oxidized low-density lipoprotein (OxLDL) and how it would affect the progression of atherosclerosis in low-density lipoprotein receptor-deficient (LDLR-/-) mice. The data revealed a prominent IgM but not IgG response to malondialdehyde-acetaldehyde modified LDL (MAA-LDL) after Rgp44 and Pg immunizations, implying that Rgp44/Pg and MAA adducts may share cross-reactive epitopes that prompt IgM antibody production and consequently confer atheroprotection...
2018: PloS One
https://www.readbyqxmd.com/read/29328492/exosomes-derived-from-oxidized-ldl-stimulated-macrophages-attenuate-the-growth-and-tube-formation-of-endothelial-cells
#3
Chaoyang Huang, Yuan Huang, Yijiang Zhou, Wencheng Nie, Xiangyuan Pu, Xiaolei Xu, Jianhua Zhu
Oxidized low-density lipoprotein (oxLDL) has a critical role in the development of atherosclerosis. The participation of oxLDL‑stimulated macrophages has been well‑established in atherosclerosis, however the underlying mechanisms are unclear. Macrophage‑derived exosomes are actively released and are involved in numerous physiological and pathological processes. However, the function of exosomes secreted by oxLDL‑stimulated macrophages in atherosclerosis remains unknown. Exosomes from oxLDL‑treated macrophages and controls were co‑cultured with endothelial cells and the exosomes were taken up by endocytosis...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29298513/andrographolide-inhibits-oxidized-ldl-induced-cholesterol-accumulation-and-foam-cell-formation-in-macrophages
#4
Hung-Chih Lin, Chong-Kuei Lii, Hui-Chun Chen, Ai-Hsuan Lin, Ya-Chen Yang, Haw-Wen Chen
oxLDL is involved in the pathogenesis of atherosclerotic lesions through cholesterol accumulation in macrophage foam cells. Andrographolide, the bioactive component of Andrographis paniculata, possesses several biological activities such as anti-inflammatory, anti-oxidant, and anticancer functions. Scavenger receptors (SRs), including class A SR (SR-A) and CD36, are responsible for the internalization of oxLDL. In contrast, receptors for reverse cholesterol transport, including ABCA1 and ABCG1, mediate the efflux of cholesterol from macrophage foam cells...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29297961/serum-antibodies-against-oxidized-ldl-in-children-and-adolescents-with-and-without-hypercholesterolemia
#5
Anastasia Garoufi, Antonios Marmarinos, Venetia-Maria Vraila, Stamatina Dimou, Athanasia Pagoni, Styliani Vorre, Irene Paraskakis, Dimitrios Gourgiotis
BACKGROUND: The oxidative modification of LDL (oxLDL) appears to play a key role in the early developmental stages of atherosclerosis. Increased serum antibodies against the oxLDL (anti-oxLDL antibodies) have been found in adults with atherosclerotic diseases, as well as in healthy ones. However, the clinical significance and its precise role, atherogenic or atheroprotective, have not been yet clarified. This study aims in evaluating anti-oxLDL antibodies in healthy children and adolescents with- and without hypercholesterolemia...
January 3, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29277441/iga-antibodies-to-phosphocholine-associate-with-long-term-cardiovascular-disease-risk
#6
Jari Kankaanpää, Maritta Sämpi, Risto Bloigu, Chunguang Wang, Ramin Akhi, Y Antero Kesäniemi, Anne M Remes, Olavi Ukkola, Sohvi Hörkkö
BACKGROUND AND AIMS: Antibodies to phosphocholine and oxidized LDL (oxLDL) are proposed to modify progression of atherosclerosis. We investigated the prognostic value of antibodies to phosphocholine (PCho), Streptococcus pneumoniae cell wall polysaccharide (CWPS) and oxLDL in defining long-term CVD survival. METHODS: CVD incidence was followed for 18 years and analyzed with baseline plasma IgM, IgG and IgA antibody levels to PCho, CWPS and oxLDL in 1044 subjects of Oulu Project Elucidating Risk of Atherosclerosis study (OPERA)...
December 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29215758/plin5-deficiency-promotes-atherosclerosis-progression-through-accelerating-inflammation-apoptosis-and-oxidative-stress
#7
Peng-Li Zhou, Min Li, Xin-Wei Han, Yong-Hua Bi, Wen-Guang Zhang, Zheng-Yang Wu, Gang Wu
Excessive plasma triglyceride and cholesterol levels promote the progression of several prevalent cardiovascular risk factors, including atherosclerosis, which is a leading death cause. Perilipin 5 (Plin5), an important perilipin protein, is abundant in tissues with very active lipid catabolism, and is involved in the regulation of oxidative stress. Although, in?ammation and oxidative stress play a critical role in atherosclerosis development, the underlying mechanisms are complex and not completely understood...
December 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29197506/cadmium-exposure-exacerbates-severe-hyperlipidemia-and-fatty-liver-changes-in-zebrafish-via-impairment-of-high-density-lipoproteins-functionality
#8
Jae-Yong Kim, Suk-Jeong Kim, Myung Ae Bae, Jae-Ryong Kim, Kyung-Hyun Cho
Cadmium (Cd) is a heavy metal with several toxicities that have destructive effect on most organ systems. However, its toxic effects on human lipoproteins are largely remained unknown especially in hyperlipidemic zebrafish model. Treatment of human high-density lipoprotein (HDL) with cadmium chloride (CdCl2, final 12 and 24μM) caused spontaneous formation of multimeric apoA-I as well as increased production of glycated extent products. Cd-HDL3 accelerated uptake of oxidized LDL (oxLDL) into macrophages and induced severe senescence in human dermal fibroblast (HDF) cells...
November 29, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29195136/oxidized-ldl-triggers-changes-in-oxidative-stress-and-inflammatory-biomarkers-in-human-macrophages
#9
Oscar J Lara-Guzmán, Ángel Gil-Izquierdo, Sonia Medina, Edison Osorio, Rafael Álvarez-Quintero, Natalia Zuluaga, Camille Oger, Jean-Marie Galano, Thierry Durand, Katalina Muñoz-Durango
Oxidized low-density lipoprotein (oxLDL) is a well-recognized proatherogenic particle that functions in atherosclerosis. In this study, we established conditions to generate human oxLDL, characterized according to the grade of lipid and protein oxidation, particle size and oxylipin content. The induction effect of the cellular proatherogenic response was assessed in foam cells by using an oxLDL-macrophage interaction model. Uptake of oxLDL, reactive oxygen species production and expression of oxLDL receptors (CD36, SR-A and LOX-1) were significantly increased in THP-1 macrophages...
November 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/29171157/bioavailability-of-terpenes-and-postprandial-effect-on-human-antioxidant-potential-an-open-label-study-in-healthy-subjects
#10
Efstathia Papada, Aristea Gioxari, Vincent Brieudes, Charalampia Amerikanou, Maria Halabalaki, Alexios Leandros Skaltsounis, Ilias Smyrnioudis, Andriana C Kaliora
SCOPE: To assess bioavailability of terpenes in human plasma and their effect on oxidative stress biomarkers. METHODS AND RESULTS: In this open-label and single arm postprandial trial, seventeen healthy male volunteers (20-40 years old) followed a low-phytochemical diet for 5 days. Next, after overnight fasting, volunteers consumed Mastiha powder (a natural resin rich in terpenes) dispersed in water. Blood samples were collected on time-points 0h (before ingestion) and 0...
November 23, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29161690/catechins-blunt-the-effects-of-oxldl-and-its-primary-metabolite-phosphatidylcholine-hydroperoxide-on-endothelial-dysfunction-through-inhibition-of-oxidative-stress-and-restoration-of-enos-in-rats
#11
Hao-Hsiang Chang, Chen-Yen Chien, Kuo-Hsin Chen, Shih-Chung Huang, Chiang-Ting Chien
BACKGROUND/AIMS: We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hydroperoxide (PCOOH) induced oxidative injury in cultured endothelial cell line and rats. METHODS: We used endothelial cell line and male Wistar rats to determine the effect of catechins on oxLDL or PCOOH induced oxidative injury including apoptosis, H2O2 level, vascular responses and urinary 8-isoprostane and nitrite/nitrate concentration...
November 22, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29118901/impacts-of-berberine-on-oxidized-ldl-induced-proliferation-of-human-umbilical-vein-endothelial-cells
#12
Rui-Xia Xu, Xian-Chang Sun, Chun-Yan Ma, Yu-Hong Yao, Xiao-Lin Li, Yuan-Lin Guo, Yan Zhang, Sha Li, Jian-Jun Li
Berberine (BBR), a Chinese medicine extracted from natural plant, has been demonstrated to improve lipid disorders. Oxidized low-density lipoprotein (oxLDL), a proatherogenic lipoprotein, has been shown to be involved in vascular endothelial cell dysfunction such as excessive or abnormal proliferation. The purpose of the present study was to investigate the impacts of BBR on cell proliferations as well as potential involving signal pathways. HUVECs were stimulated with oxLDL and co-cultured with BBR at a variety of concentrations in different time points...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29104665/synergistic-enhancement-of-matrix-metalloproteinase-9-expression-and-pro-inflammatory-cytokines-by-influenza-virus-infection-and-oxidized-ldl-treatment-in-human-endothelial-cells
#13
Yun Wu, He Huang
Oxidized low-density lipoprotein (oxLDL) has been reported to contribute to the development and progression of atherosclerosis, which is also stimulated by viral infections, such as influenza. However, the mechanism underlining the promotion of atherosclerosis by both risk factors remains unclear. In the present study, we investigated the expression of matrix metalloproteinase-9 (MMP-9), which is one of key mediators of atherosclerosis progression, in oxLDL-treated human umbilical vein endothelial cells (HUVEC)-C cells...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29078142/electronegative-l5-ldl-induces-the-production-of-g-csf-and-gm-csf-in-human-macrophages-through-lox-1-involving-nf-%C3%AE%C2%BAb-and-erk2-activation
#14
Tzu-Ching Yang, Po-Yuan Chang, Tzu-Ling Kuo, Shao-Chun Lu
BACKGROUND AND AIMS: Circulating levels of granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) are associated with the severity of acute myocardial infarction (AMI). However, what causes increases in G-CSF and GM-CSF is unclear. In this study, we investigated whether L5-low-density lipoprotein (LDL), a mildly oxidized LDL from AMI, can induce G-CSF and GM-CSF production in human macrophages. METHODS: L1-LDL and L5-LDL were isolated through anion-exchange chromatography from AMI plasma...
October 14, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29077566/relations-between-oxidized-low-density-lipoproteins-and-fat-soluble-vitamin-concentrations-in-obese-children-preliminary-study
#15
Joanna Gajewska, Jadwiga Ambroszkiewicz, Halina Weker, Magdalena Chełchowska
INTRODUCTION: Although lipid peroxidation products are formed during normal cell metabolism, they appear mostly in pathological conditions via producing an excess of free radicals that can react with unsaturated fatty acids, in particular low-density lipoprotein (LDL). The aim of this study was to investigate the relations between oxidized LDL (oxLDL), the fat-soluble vitamin status and the anthropometric parameters in prepubertal obese children. MATERIAL AND METHODS: Thirty-two obese (SDS-BMI >2) and 25 non-obese children (SDS-BMI <-1+1>) were included in the study...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/29054360/enhanced-radical-scavenging-activity-of-a-procyanidin-b3-analogue-comprised-of-a-dimer-of-planar-catechin
#16
Mirei Mizuno, Ikuo Nakanishi, Ken-Ichiro Matsumoto, Kiyoshi Fukuhara
Proanthocyanidins are oligomers of catechins that exhibit potent antioxidative activity and inhibit binding of oxidized low-density lipoprotein (OxLDL) to the lectin-like oxidized LDL receptor (LOX-1), which is involved in the onset and development of arteriosclerosis. Previous attempts aimed at developing proanthocyanidin derivatives with more potent antioxidative activity and stronger inhibition for LOX-1 demonstrated the synthesis of a novel proanthocyanidin derivative (1), in which the geometry of one catechin molecule in procyanidin B3 was constrained to a planar orientation...
November 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29016810/mir-30c-5p-regulates-macrophage-mediated-inflammation-and-pro-atherosclerosis-pathways
#17
Giulio Ceolotto, Alessandra Giannella, Mattia Albiero, Maniselvan Kuppusamy, Claudia Radu, Paolo Simioni, Katia Garlaschelli, Andrea Baragetti, Alberico Luigi Catapano, Elisabetta Iori, Gian Paolo Fadini, Angelo Avogaro, Saula Vigili de Kreutzenberg
Aims: Atherosclerosis is an inflammatory disease wherein cholesterol-loaded macrophages play a major role. MicroRNAs and microparticles propagate inflammatory pathways and are involved in cardiovascular disease. We aimed to screen and validate circulating microRNAs correlated with atherosclerosis development in humans, and to dissect the molecular mechanisms associated with atherogenesis using in vitro and in vivo approaches. Methods and results: A panel of 179 secreted microRNAs was screened in plasma samples of patients with and without atherosclerosis, and validated cross-sectionally and prospectively in patients followed for up to 11 years...
November 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28983628/long-intergenic-noncoding-rna-p21-mediates-oxidized-ldl%C3%A2-induced-apoptosis-and-expression-of-lox%C3%A2-1-in-human-coronary-artery-endothelial-cells
#18
Tao Zhou, Xiaofang Chen
Atherosclerosis is the most common pathological cause of cardiovascular diseases, and endothelial dysfunction has a vital role. It has been suggested that inhibiting endothelial cell apoptosis induced by oxidized low‑density lipoprotein (ox‑LDL), an essential atherosclerotic factor, is a potential novel therapeutic strategy against atherosclerosis. Previous studies have revealed that endothelial lectin‑like ox‑LDL receptor‑1 (LOX‑1) and long intergenic noncoding RNA p21 (lincRNA‑p21) may serve as therapeutic targets for atherosclerosis and associated cardiovascular disorders...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28959869/-binding-of-glycoprotein-%C3%AE-%C3%A2-gpi-with-oxidized-low-density-lipoprotein
#19
He Zhang, Jingda Li, Amei Chen, Qingping Liu
We analyzed the binding of P.rβ₂-GPI-DV with ox-LDL by fluorescence, molecular simulation and circular dichroism. We used SDS-PAGE and Western blotting to identify the purity of P.rβ₂-GPI-DV, fluorescence, circular dichroism spectroscopy and molecular docking simulation to analyze the binding between P.rβ₂-GPI-DV and oxLDL. P.rβ₂-GPI-DV was specifically recognized by anti-His antibody at 12 kDa position. The chromophoric groups, the changes of secondary structure and the molecular docking simulations revealed that the active pocket formed by Cys281-Lys-Asn-Lys-Glu-Lys-Lys287 and Leu313-Ala-Phe-Trp316 of P...
January 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28947858/psoriasis-and-cardiovascular-risk-do-promising-new-biomarkers-have-clinical-impact
#20
REVIEW
Sirje Kaur, Külli Kingo, Mihkel Zilmer
Epidemiological studies suggest an increased prevalence of cardiovascular disease (CVD) in patients with psoriasis (PS). Therefore, emphasis has lately been laid on the necessity for clinical evaluation of the risk of CVD in these patients. The systemic inflammatory markers C-reactive protein (CRP) and interleukin- (IL-) 6, which have long been used to predict future CVD in the general population, are increased manyfold in patients with PS. Lipid abnormalities characterized by elevated triglycerides, low HDL cholesterol, and higher concentrations of LDL cholesterol and its oxidized form are also prevalent in patients...
2017: Mediators of Inflammation
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