keyword
MENU ▼
Read by QxMD icon Read
search

IFN-gamma signaling

keyword
https://www.readbyqxmd.com/read/27927222/tollip-an-early-regulator-of-the-acute-inflammatory-response-in-the-substantia-nigra
#1
Marie Humbert-Claude, D Duc, D Dwir, L Thieren, J Sandström von Tobel, C Begka, F Legueux, D Velin, M H Maillard, K Q Do, F Monnet-Tschudi, L Tenenbaum
BACKGROUND: Tollip is a ubiquitously expressed protein, originally described as a modulator of the IL-1R/TLR-NF-κB signaling pathways. Although this property has been well characterized in peripheral cells, and despite some evidence of its expression in the central nervous system, the role of Tollip in neuroinflammation remains poorly understood. The present study sought to explore the implication of Tollip in inflammation in the substantia nigra pars compacta, the structure affected in Parkinson's disease...
December 7, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27926863/chronic-infection-depletes-hematopoietic-stem-cells-through-stress-induced-terminal-differentiation
#2
Katie A Matatall, Mira Jeong, Siyi Chen, Deqiang Sun, Fengju Chen, Qianxing Mo, Marek Kimmel, Katherine Y King
Chronic infections affect a third of the world's population and can cause bone marrow suppression, a severe condition that increases mortality from infection. To uncover the basis for infection-associated bone marrow suppression, we conducted repeated infection of WT mice with Mycobacterium avium. After 4-6 months, mice became pancytopenic. Their hematopoietic stem and progenitor cells (HSPCs) were severely depleted and displayed interferon gamma (IFN-γ) signaling-dependent defects in self-renewal. There was no evidence of increased HSPC mobilization or apoptosis...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27863906/post-translational-control-of-intracellular-pathogen-sensing-pathways
#3
REVIEW
Cindy Chiang, Michaela U Gack
Mammalian cells recognize virus-derived nucleic acids using a defined set of intracellular sensors including the DNA sensors cyclic GMP-AMP (cGAMP) synthase (cGAS) and interferon gamma (IFNγ)-inducible protein 16 (IFI16) as well as viral RNA receptors of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family. Following innate immune recognition, these sensors launch an immune response that is characterized by the transcriptional upregulation of many antiviral molecules, including proinflammatory cytokines, chemokines, and IFN-stimulated genes...
November 15, 2016: Trends in Immunology
https://www.readbyqxmd.com/read/27853137/cug-binding-protein-1-regulates-hsc-activation-and-liver-fibrogenesis
#4
Xingxin Wu, Xudong Wu, Yuxiang Ma, Fenli Shao, Yang Tan, Tao Tan, Liyun Gu, Yang Zhou, Beicheng Sun, Yang Sun, Xuefeng Wu, Qiang Xu
Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression is elevated in HSCs and positively correlates with liver fibrosis severity in human liver biopsies. Transforming growth factor-beta (TGF-β) selectively increases CUGBP1 expression in cultured HSCs in a p38 mitogen-activated protein kinase (MAPK)-dependent manner. Knockdown of CUGBP1 inhibits alpha smooth muscle actin (α-SMA) expression and promotes interferon gamma (IFN-γ) production in HSCs in vitro...
November 17, 2016: Nature Communications
https://www.readbyqxmd.com/read/27834206/stat1-signaling-in-astrocytes-is-essential-for-control-of-infection-in-the-central-nervous-system
#5
Shinya Hidano, Louise M Randall, Lucas Dawson, Hans K Dietrich, Christoph Konradt, Peter J Klover, Beena John, Tajie H Harris, Qun Fang, Bradley Turek, Takashi Kobayashi, Lothar Hennighausen, Daniel P Beiting, Anita A Koshy, Christopher A Hunter
: The local production of gamma interferon (IFN-γ) is important to control Toxoplasma gondii in the brain, but the basis for these protective effects is not fully understood. The studies presented here reveal that the ability of IFN-γ to inhibit parasite replication in astrocytes in vitro is dependent on signal transducer and activator of transcription 1 (STAT1) and that mice that specifically lack STAT1 in astrocytes are unable to limit parasite replication in the central nervous system (CNS)...
November 8, 2016: MBio
https://www.readbyqxmd.com/read/27825337/reno-protective-effect-and-mechanism-study-of-huang-lian-jie-du-decoction-on-lupus-nephritis-mrl-lpr-mice
#6
Xiaoli Nie, Rong Deng, Lei Xiang, Pingping Jiang, Qi Xue
BACKGROUND: Huang Lian Jie Du Decoction (HLJDD), a very famous traditional Chinese medicinal prescription, has been used for heat dissipation and detoxification in China. This study was aimed to evaluate the reno-protective effects of HLJDD against lupus nephritis (LN) in vivo in MRL/lpr mice. METHODS: Animals were administered orally every day for eight consecutive weeks except the mice of normal group and model group. Organ indexes, serum interleukin-6 (IL-6), interleukin-10 (IL-10), interferon-gamma (IFN-γ) and the anti-double stranded DNA (anti-dsDNA) antibody were tested, respectively...
November 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27824650/vsl-3-probiotic-stimulates-t-cell-protein-tyrosine-phosphatase-mediated-recovery-of-ifn-%C3%AE-induced-intestinal-epithelial-barrier-defects
#7
Moorthy Krishnan, Harrison M Penrose, Nilay N Shah, Ronald R Marchelletta, Declan F McCole
BACKGROUND: VSL#3 is a probiotic compound that has been used in the treatment of inflammatory bowel disease. T-cell protein tyrosine phosphatase (TCPTP) is the protein product of the inflammatory bowel disease candidate gene, PTPN2, and we have previously shown that it protects epithelial barrier function. The aim of this study was to investigate whether VSL#3 improves intestinal epithelial barrier function against the effects of the inflammatory bowel disease-associated proinflammatory cytokine, interferon-gamma (IFN-γ) through activation of TCPTP...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27817193/effect-of-microrna-155-on-the-interferon-gamma-signaling-pathway-in-biliary-atresia
#8
Yu-An Hsu, Chih-Hung Lin, Hui-Ju Lin, Chi-Chun Huang, Hsiu-Chu Lin, Ying-Chi Chen, Ching-Yao Chang, Su-Hua Huang, Jane-Ming Lin, Kuan-Rong Lee, Lei Wan
MicroRNAs (miRNAs) are ~22-nucleotide long RNAs that negatively regulate gene expression and inflammatory responses in eukaryotes. The aim of this work was to evaluate the roles of miRNA (miR)-155 on the interferon-γ (IFN-γ)-induced response in biliary atresia (BA), which is the most common form of pediatric chronic liver disease and a leading indication for pediatric liver transplantation. The expression of miR-155 and the suppressor of cytokine signaling 1 (SOCS1) gene in human and mice liver tissues of BA and healthy controls was evaluated...
December 31, 2016: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/27795415/irf-1-and-type-i-interferon-cooperate-to-control-acute-gammaherpesvirus-infection
#9
Wadzanai P Mboko, Michaela M Rekow, Mitchell P Ledwith, Philip T Lange, Kaitlin E Schmitz, Sean Anderson, Vera L Tarakanova
: Gammaherpesviruses are ubiquitous pathogens that establish life-long infection in >95% of adults worldwide, and are associated with a variety of malignancies. Coevolution of gammaherpesviruses with their hosts has resulted in an intricate relationship between the virus and the host immune system, and perturbation of the virus-host balance results in pathology. Interferon regulatory factor 1 (IRF-1) is a tumor suppressor that is also involved in the regulation of innate and adaptive immune responses...
October 26, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27784631/structural-and-functional-annotation-of-human-fam26f-a-multifaceted-protein-having-a-critical-role-in-the-immune-system
#10
Uzma Malik, Aneela Javed, Amjad Ali, Kashif Asghar
BACKGROUND: Human immune system is a complex amalgam of a greatly diverse ensemble comprising of various cellular and non-cellular components, including proteins. FAM26F (family with sequence similarity 26, member F) is a relatively recently identified gene reported to play important role in diverse immune responses. Numerous studies have reported FAM26F to be differentially expressed in several viral, bacterial and parasitic infections, in certain pathophysiological conditions such as heart and liver transplantation, and in several cancers...
January 15, 2017: Gene
https://www.readbyqxmd.com/read/27771055/induction-of-functional-interferon-alpha-and-gamma-responses-during-acute-infection-of-cattle-with-non-cytopathic-bovine-viral-diarrhea-virus
#11
Brenden Van Wyk, Marlene Snider, Erin Scruten, Sylvia van Drunen Littel-van den Hurk, Scott Napper
As a part of their pathogenic mechanism, many pathogens causing persistent infections, including bovine viral diarrhea virus (BVDV), immunosuppress their hosts, often by limiting the ability to either produce, or respond to, interferon. The objective of this study was to quantify the extent to which an acute infection of cattle with a non-cytopathic strain of BVDV induces interferon responses and to establish the functionality of these responses. Functionality of responses was investigated using a bovine specific peptide array to monitor kinase-mediated signal transduction activity within peripheral blood mononuclear cells (PBMCs) at time points corresponding to the interferon gamma (IFN-γ) and alpha (IFN-α) responsive phases of acute BVDV infection...
November 15, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27762732/epithelial-cells-secrete-interferon-%C3%AE-which-suppresses-expression-of-receptor-activator-of-nuclear-factor-kappa-b-ligand-in-human-mandibular-osteoblast-like-cells
#12
Pakchisa Khonsuphap, Prasit Pavasant, Rizky Aditya Irwandi, Chidchanok Leethanakul, Anjalee Vacharaksa
BACKGROUND: Prostaglandin E2 (PGE2) accumulates in inflamed periodontal tissue and induces the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK-osteoprotegerin (OPG) signaling associated with bone resorption. Although oral epithelial cells maintain tissue homeostasis, the role of these cells in RANKL regulation remains unknown. METHODS: To mimic inflamed condition, RANKL upregulation in human mandibular osteoblast-like cells (HMOBs) were stimulated with PGE2...
October 20, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27751819/a-fumigaclavine-c-isostere-alleviates-th1-mediated-experimental-colitis-via-competing-with-ifn-%C3%AE-for-binding-to-ifn-%C3%AE-receptor-1
#13
Yang Tan, Xingxin Wu, Jing Sun, Wenjie Guo, Fangyuan Gong, Fenli Shao, Tao Tan, Yi Cao, Bingfeng Zheng, Yanhong Gu, Yang Sun, Qiang Xu
Interferon gamma (IFN-γ) signaling in T cells plays an important role in developing T helper 1 (Th1)-mediated inflammation. Selective regulation of IFN-γ signaling is an attractive strategy for treating Th1-mediated immune diseases. In this study, we aimed to explore possible means of targeting IFN-γ signaling by using small molecule compound. A synthetic small molecule FC9 was identified as it selectively inhibited IFN-γ signaling in T cells without suppressing interleukin 4 (IL-4) signaling. Furthermore, FC9 inhibited IFN-γ-induced Janus kinase 2 (JAK2) activation via competing with IFN-γ for binding to IFN-γ receptor 1 (IFN-γ R1)...
October 14, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27734406/regulation-of-ifn-%C3%AE-expression
#14
John Fenimore, Howard A Young
Interferon gamma, referred to here as IFN-γ, is a major component in immunological cell signaling and is a critical regulatory protein for overall immune system function. First discovered in 1965 (Wheelock Science 149: (3681)310-311, 1965), IFN-γ is the only Type II interferon identified. Its expression is both positively and negatively controlled by different factors. In this chapter, we will review the transcriptional and post-transcriptional control of IFN-γ expression. In the transcriptional control part, the regular activators and suppressors are summarized, we will also focus on the epigenetic control, such as chromosome access, DNA methylation, and histone acetylation...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27733811/proinflammatory-cytokines-decrease-the-expression-of-genes-critical-for-rpe-function
#15
R Krishnan Kutty, William Samuel, Kaifa Boyce, Aswini Cherukuri, Todd Duncan, Cynthia Jaworski, Chandrasekharam N Nagineni, T Michael Redmond
PURPOSE: Proinflammatory cytokines interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and interleukin-1 beta (IL-1β) secreted by infiltrating lymphocytes or macrophages may play a role in triggering RPE dysfunction associated with age-related macular degeneration (AMD). Binding of these proinflammatory cytokines to their specific receptors residing on the RPE cell surface can activate signaling pathways that, in turn, may dysregulate cellular gene expression. The purpose of the present study was to investigate whether IFN-γ, TNF-α, and IL-1β have an adverse effect on the expression of genes essential for RPE function, employing the RPE cell line ARPE-19 as a model system...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27667782/interferon-gamma-modulation-of-disease-manifestation-and-the-local-antibody-response-to-alphavirus-encephalomyelitis
#16
Victoria K Baxter, Diane E Griffin
Infection of mice with Sindbis virus (SINV) produces encephalomyelitis and provides a model for examination of the central nervous system (CNS) immune response to alphavirus infection. Clearance of infectious virus is accomplished through a cooperative effort between SINV-specific antibody and IFN-γ, but the regulatory interactions are poorly understood. To determine the effects of IFN-γ on clinical disease and the antiviral immune response, C57BL/6 mice lacking IFN-γ (Ifng-/-) or IFN-γ receptor (Ifngr1-/-) were studied in comparison to WT mice...
November 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27647657/up-regulation-of-pkr-signaling-pathway-by-ethanol-displays-an-age-of-onset-dependent-relationship
#17
Jeremy W Duncan, Shakevia Johnson, Xiao Zhang, Baoying Zheng, Jia Luo, Xiao-Ming Ou, Craig A Stockmeier, Jun Ming Wang
BACKGROUND: Ethanol (EtOH) neurotoxicity can result in devastating effects on brain and behavior by disrupting homeostatic signaling cascades and inducing cell death. One such mechanism involves double-stranded RNA activated protein kinase (PKR), a primary regulator of protein translation and cell viability in the presence of a virus or other external stimuli. EtOH-mediated up-regulation of interferon-gamma (IFN-γ; the oxidative stress-inducible regulator of PKR), PKR, and its target, p53, are still being fully elucidated...
September 20, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27603577/conversion-of-nonproliferating-astrocytes-into-neurogenic-neural-stem-cells-control-by-fgf2-and-interferon-%C3%AE
#18
Susanne Kleiderman, Simon Gutbier, Kemal Ugur Tufekci, Felipe Ortega, João V Sá, Ana P Teixeira, Catarina Brito, Enrico Glaab, Benedikt Berninger, Paula M Alves, Marcel Leist
Conversion of astrocytes to neurons, via de-differentiation to neural stem cells (NSC), may be a new approach to treat neurodegenerative diseases and brain injuries. The signaling factors affecting such a cell conversion are poorly understood, and they are hard to identify in complex disease models or conventional cell cultures. To address this question, we developed a serum-free, strictly controlled culture system of pure and homogeneous "astrocytes generated from murine embryonic stem cells (ESC)." These stem cell derived astrocytes (mAGES), as well as standard primary astrocytes resumed proliferation upon addition of FGF...
September 7, 2016: Stem Cells
https://www.readbyqxmd.com/read/27590046/impact-of-heart-rate-variability-a-marker-for-cardiac-health-on-lupus-disease-activity
#19
Aikaterini Thanou, Stavros Stavrakis, John W Dyer, Melissa E Munroe, Judith A James, Joan T Merrill
BACKGROUND: Decreased heart rate variability (HRV) is associated with adverse outcomes in cardiovascular diseases and has been observed in patients with systemic lupus erythematosus (SLE). We examined the relationship of HRV with SLE disease activity and selected cytokine pathways. METHODS: Fifty-three patients from the Oklahoma Lupus Cohort were evaluated at two visits each. Clinical assessments included the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), British Isles Lupus Assessment Group (BILAG) index, physician global assessment (PGA), and Safety of Estrogens in Lupus Erythematosus National Assessment-SLEDAI Flare Index...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27577704/porphyromonas-gingivalis-induces-il-8-and-ifn-gamma-secretion-and-apoptosis-in-human-extravillous-trophoblast-derived-htr8-svneo-cells-via-activation-of-erk1-2-and-p38-signaling-pathways
#20
Hongyu Ren, Yuhong Li, Han Jiang, Minquan Du
INTRODUCTION: Preterm birth is a major cause for infant mortality and morbidity. A large number of studies have suggested a link between periodontal disease and preterm birth. The purpose of this study was to investigate the interaction between a periodontopathic bacterium Porphyromonas gingivalis and human extravillous trophoblast derived HTR8/SVneo cells. METHODS: Production of cytokines in HTR8 cells was measured via ELISA. Annexin V/PI flow cytometry was performed to assess apoptosis...
September 2016: Placenta
keyword
keyword
75939
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"