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IFN-gamma signaling

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https://www.readbyqxmd.com/read/29780381/interferon-gamma-at-the-crossroads-of-tumor-immune-surveillance-or-evasion
#1
REVIEW
Flávia Castro, Ana Patrícia Cardoso, Raquel Madeira Gonçalves, Karine Serre, Maria José Oliveira
Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases, despite its adverse effects. Although broad evidence implicating IFN-γ in tumor immune surveillance, IFN-γ-based therapies undergoing clinical trials have been of limited success. In fact, recent reports suggested that it may also play a protumorigenic role, namely, through IFN-γ signaling insensitivity, downregulation of major histocompatibility complexes, and upregulation of indoleamine 2,3-dioxygenase and of checkpoint inhibitors, as programmed cell-death ligand 1...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29774490/higher-activation-of-the-interferon-gamma-signaling-pathway-in-systemic-lupus-erythematosus-patients-with-a-high-type-i-ifn-score-relation-to-disease-activity
#2
Manman Liu, Junli Liu, Shumeng Hao, Ping Wu, Xiaoyan Zhang, Yichuan Xiao, Gengru Jiang, Xinfang Huang
Increased IFN-γ levels have been associated with systemic lupus erythematosus (SLE). However, the relationships among IFN-γ, type I interferons (IFNs) and clinical features have not been extensively studied. Peripheral blood samples from 44 SLE patients and 36 healthy donors (HDs) were collected. Quantitative real-time PCR was used to assess the mRNA expression of IFNG, type II IFN-inducible genes (IRF1, GBP1, CXCL9, CXCL10, and SERPING1, which are used for the type II IFN score), type I IFN-inducible genes (IRF7, MX1, ISG15, and ISG20, which are used for the type I IFN score), TBX21, and EOMES in peripheral blood mononuclear cells...
May 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29746817/arginine-inhibits-the-malignant-transformation-induced-by-interferon-gamma-through-the-nf-%C3%AE%C2%BAb-gcn2-eif2%C3%AE-signaling-pathway-in-mammary-epithelial-cells-in-vitro-and-in-vivo
#3
Wenbo Ren, Yang Li, Xiaojing Xia, Wenfei Guo, Taiyu Zhai, Yuting Jin, Yanyi Che, Haidi Gao, Xiumei Duan, Tinghao Huang, Jing Huang, Liancheng Lei
Breast cancer is the most common female malignant tumors in the world. It seriously affects women's physical and mental health and the leading cause of cancer death among women. Our previous study demonstrated that diet-derived IFN-γ promoted the malignant transformation of primary bovine mammary epithelial cells by accelerating arginine depletion. The current study aimed to explore whether arginine addition could inhibit the degree of malignant transformation and its molecular mechanism. The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-γ, including reducing cell proliferation, cell migration and colony formation, through the NF-κB-GCN2/eIF2α pathway...
May 7, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29715554/rehmannia-glutinosa-polysaccharide-promoted-activation-of-human-dendritic-cells
#4
Yuhua Wang, Minseok Kwak, Peter Chang-Whan Lee, Jun-O Jin
In our previous study, we showed that Rehmannia glutinosa polysaccharide (RGP) treatment induced maturation of dendritic cells (DCs) and that it had an anticancer effect in mice. The effect of RGP has not been studied in human DCs, including monocyte-derived DCs (MDDCs) and peripheral blood DCs (PBDCs). In this study, we examined DC activation by RGP in human cells. The dendritic morphology of RGP-treated MDDCs was substantially altered as compared with that of phosphate-buffered saline (PBS)-treated control cells...
April 28, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29710534/antiviral-effects-of-ma-huang-tang-against-h1n1-influenza-virus-infection-in-vitro-and-in-an-icr-pneumonia-mouse-model
#5
Wenyang Wei, Haitong Wan, Xueqian Peng, Huifen Zhou, Yiyu Lu, Yu He
Ma Huang Tang (MHT), a classical Chinese herbal decoction which has been used in clinic for thousands of years, was very effective in treating the upper respiratory tract infection. But its activity against influenza virus A, the anti-inflammatory effect and the underlying mechanisms have been poorly investigated in previous researches. In this study, the antiviral efficacy of MHT directly inhibiting influenza virus A was investigated in vitro in MDCK cells. In an ICR pneumonia mouse model infected with influenza virus A PR/8/34, MHT (8, 4 and 2 g/kg) were oral administrated for 7 days after viral challenge, to evaluate the effect of MHT on ameliorating viral pneumonia and decipher the underlying mechanisms...
April 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29696509/inhibiting-il-2-signaling-and-the-regulatory-t-cell-pathway-using-computationally-designed-peptides
#6
Tammy Price-Troska, Zhi-Zhang Yang, David Diller, Alexander Bayden, Mark Jarosinski, Joseph Audie, Stephen M Ansell
Background Increased serum levels of soluble interleukin-2 (IL-2) receptor alpha (sIL-2Rα) are an indicator of poor prognosis in patients with B-cell non-Hodgkin lymphoma (NHL). By binding to IL-2, sIL-2Rα upregulates Foxp3 expression and induces the development of regulatory T (Treg ) cells. Methods To inhibit the binding of IL-2 to sIL-2Rα with the goal of suppressing the induction of Foxp3 and decreasing Treg cell numbers, we developed peptides by structure-based computational design to disrupt the interaction between IL-2 and sIL-2Rα...
April 26, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29627530/an-enriched-environment-restores-hepatitis-b-vaccination-mediated-impairments-in-synaptic-function-through-ifn-%C3%AE-arginase1-signaling
#7
Fangfang Qi, Zejie Zuo, Saisai Hu, Yucen Xia, Dan Song, Jiechen Kong, Yang Yang, Yingying Wu, Xiao Wang, Junhua Yang, Dandan Hu, Qunfang Yuan, Juntao Zou, Kaihua Guo, Jie Xu, Zhibin Yao
Activation of the neonatal immune system may contribute to deficits in neuronal plasticity. We have reported that neonatal vaccination with a hepatitis B vaccine (HBV) transiently impairs mood status and spatial memory involving a systemic T helper (Th) 2 bias and M1 microglial activation. Here, an EE induced microglial anti-inflammatory M2 polarization, as evidenced by selectively enhanced expression of the Arginase1 gene (Arg-1) in the hippocampus. Interestingly, knock-down of the Arg-1 gene prevented the effects of EE on restoring the dendritic spine density...
April 5, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29619982/sting-dependent-interferon-%C3%AE-1-induction-in-ht29-cells-a-human-colorectal-cancer-cell-line-after-gamma-radiation
#8
Jianzhou Chen, Bostjan Markelc, Jakob Kaeppler, Vivian M L Ogundipe, Yunhong Cao, W Gillies McKenna, Ruth J Muschel
PURPOSE: To investigate the induction of type III interferons (IFNs) in human cancer cells by gamma-rays. METHODS AND MATERIALS: Type III IFN expression in human cancer cell lines after gamma-ray irradiation in vitro was assessed by reverse transcription-quantitative polymerase chain reaction and enzyme-linked immunosorbent assay. Signaling pathways mediating type III IFN induction were examined by a variety of means, including immunoblotting, flow cytometry, confocal imaging, and reverse transcription-quantitative polymerase chain reaction...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29616022/temporal-regulation-of-natural-killer-t-cell-interferon-gamma-responses-by-%C3%AE-catenin-dependent-and-independent-wnt-signaling
#9
Jessica C Kling, Margaret A Jordan, Lauren A Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T K Nguyen, Deepak Mittal, Rehan Villani, Raymond J Steptoe, Kiarash Khosrotehrani, Stuart P Berzins, Alan G Baxter, Dale I Godfrey, Antje Blumenthal
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity. Interferon gamma (IFN-γ) and IL-4 are key cytokines rapidly produced by NKT cells upon recognition of glycolipid antigens presented by antigen-presenting cells (APCs). It has previously been reported that the transcriptional coactivator β-catenin regulates NKT cell differentiation and functionally biases NKT cell responses toward IL-4, at the expense of IFN-γ production...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29615105/tbx21-predicts-prognosis-of-patients-and-drives-cancer-stem-cell-maintenance-via-the-tbx21-il-4-pathway-in-lung-adenocarcinoma
#10
Shuangtao Zhao, Wenzhi Shen, Jiangyong Yu, Luhua Wang
BACKGROUND: The Th1 cell-specific transcription factor TBX21 functions as a regulator of expression of a Th1 cytokine, interferon gamma (IFN-γ). However, the specific function of TBX21 correlated with cancer stemness remains unclear. METHODS: Using univariate and multivariate survival analysis, TBX21was identified as an independent predictive factor and was associated with poor prognosis in 1389 patients with lung adenocarcinoma (LUAD). Its mechanism in the prognosis was explored by functional enrichment analysis and validated in bioexperiments...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29576845/immunomodulatory-effects-of-diterpene-quinone-derivatives-from-the-roots-of-horminum-pyrenaicum-in-human-pbmc
#11
K Becker, S Schwaiger, B Waltenberger, D Fuchs, C K Pezzei, H Schennach, H Stuppner, J M Gostner
Several phytochemicals were shown to interfere with redox biology in the human system. Moreover, redox biochemistry is crucially involved in the orchestration of immunological cascades. When screening for immunomodulatory compounds, the two interferon gamma- (IFN- γ -) dependent immunometabolic pathways of tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) and neopterin formation by GTP-cyclohydrolase 1 (GTP-CH-I) represent prominent targets, as IFN- γ -related signaling is strongly sensitive to oxidative triggers...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29574308/the-influence-of-hypoxia-and-ifn-%C3%AE-on-the-proteome-and-metabolome-of-therapeutic-mesenchymal-stem-cells
#12
Holly M Wobma, Manuel A Tamargo, Shahar Goeta, Lewis M Brown, Raimon Duran-Struuck, Gordana Vunjak-Novakovic
Over the past 15 years, mesenchymal stem cells (MSCs) have been assessed for their capacity to suppress inflammation and promote tissue repair. Regardless of whether the cells are primed (exposed to instructive cues) before administration, their phenotype will respond to environmental signals present in the pathophysiological setting being treated. Since hypoxia and inflammation coexist in the settings of acute injury and chronic disease we sought to explore how the proteome and metabolome of MSCs changes when cells were exposed to 48 h of 1% oxygen, interferon gamma (IFN-γ), or both cues together...
June 2018: Biomaterials
https://www.readbyqxmd.com/read/29563896/screening-of-a-scfv-antibody-with-high-affinity-for-application-in-human-ifn-%C3%AE-immunoassay
#13
Hang Yang, Yanfang Zhong, Juncheng Wang, Qinghong Zhang, Xiulan Li, Sumei Ling, Shihua Wang, Rongzhi Wang
Interferon gamma (IFN-γ), a signal proinflammatory cytokine secreted by immune cell, and plays a critical role in the pathogenesis and progression of many diseases. It has been regarded as an important marker for determination of disease-specific immune responses. Therefore, it is urgent to develop a feasible and accurate method to detect IFN-γ in clinic real blood samples. Until now, the immunoassay based on singe chain variable fragment (scFv) antibody for human IFN-γ is still not reported. In the present study, an scFv antibody named scFv-A8 with high specificity was obtained by phage display and biopanning, with the affinity 2...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29555551/analysis-of-the-expression-patterns-of-the-cytokine-receptor-family-b-crfb-and-interferon-gamma-receptor-ifngr-in-dabry-s-sturgeon-acipenser-dabryanus
#14
Kai Luo, Shuhuan Zhang, Dongdong Tang, Lihai Xia, Weihua Gao, Guangming Tian, Zhitao Qi, Qiaoqing Xu, Wenbing Zhang
Teleost fish have more complex interferon receptor systems than mammals. In the present study, genes encoding four cytokine receptor family B (CRFBs) and two interferon gamma receptors (IFNGRs) in Dabry's sturgeon (Acipenser dabryanus) were identified by RNA-sequencing. Sequence analysis revealed that the Dabry's sturgeon CRFBs and IFNGRs contained several conserved characteristics features, including signal peptides and a transmembrane domain. Phylogenetic analysis suggested that they belong to the CRFB3, CRFB5, and IFNGR protein families, and were named CRFB3a, CRFB3b, CRFB5a, CRFB5b, IFNGR1, and IFNGR2...
July 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29523777/intracellular-desmoglein-2-cleavage-sensitizes-epithelial-cells-to-apoptosis-in-response-to-pro-inflammatory-cytokines
#15
Mark Yulis, Miguel Quiros, Roland Hilgarth, Charles A Parkos, Asma Nusrat
Desmosomal cadherins mediate intercellular adhesion and have also been shown to regulate homeostatic signaling in epithelial cells. We have previously reported that select pro-inflammatory cytokines induce Dsg2 ectodomain cleavage and shedding from intestinal epithelial cells (IECs). Dsg2 extracellular cleaved fragments (Dsg2 ECF) function to induce paracrine pro-proliferative signaling in epithelial cells. In this study, we show that exposure of IECs to pro-inflammatory cytokines interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) resulted in Dsg2 intracellular cleavage and generation of a ~55 kDa fragment (Dsg2 ICF)...
March 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29515106/a-dual-function-epidermal-growth-factor-receptor-pathway-substrate-8-eps8-derived-peptide-exhibits-a-potent-cytotoxic-t-lymphocyte-activating-effect-and-a-specific-inhibitory-activity
#16
Xiaoling Xie, Weijun Zhou, Yuxing Hu, Yiran Chen, Honghao Zhang, Yuhua Li
The identification and characterization of tumor-associated antigens (TAAs) that generate specific cytotoxic T lymphocytes (CTLs) are vital to the development of cancer immunotherapy. The epidermal growth factor receptor (EGFR) pathway substrate 8 gene (Eps8) is involved in regulating cancer progression and might be an ideal antigen. In this study, we searched for novel human leukocyte antigen (HLA)-A*2402-restricted epitopes derived from the Eps8 protein via the HLA-binding prediction algorithm. Among four candidates, peptides 327 (EFLDCFQKF), 534 (KYAKSKYDF) and 755 (LFSLNKDEL) induced peptide-specific CTLs to secrete higher levels of interferon-gamma (IFN-γ) and showed enhanced cytotoxic activity against malignant cancer cells...
March 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29510740/a-recombinant-fasciola-gigantica-14-3-3-epsilon-protein-rfg14-3-3e-modulates-various-functions-of-goat-peripheral-blood-mononuclear-cells
#17
Ai-Ling Tian, MingMin Lu, Guillermo Calderón-Mantilla, Evangelia Petsalaki, Tania Dottorini, XiaoWei Tian, YuJian Wang, Si-Yang Huang, Jun-Ling Hou, XiangRui Li, Hany M Elsheikha, Xing-Quan Zhu
BACKGROUND: The molecular structure of Fasciola gigantica 14-3-3 protein has been characterized. However, the involvement of this protein in parasite pathogenesis remains elusive and its effect on the functions of innate immune cells is unknown. We report on the cloning and expression of a recombinant F. gigantica 14-3-3 epsilon protein (rFg14-3-3e), and testing its effects on specific functions of goat peripheral blood mononuclear cells (PBMCs). METHODS: rFg14-3-3e protein was expressed in Pichia pastoris...
March 6, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29493231/small-molecular-weight-soybean-protein-derived-peptides-nutriment-attenuates-rat-burn-injury-induced-muscle-atrophy-by-modulation-of-ubiquitin-proteasome-system-and-autophagy-signaling-pathway
#18
Fen Zhao, Yonghui Yu, Wei Liu, Jian Zhang, Xinqi Liu, Lingying Liu, Huinan Yin
This article describes results of the effect of dietary supplementation with small molecular weight soybean protein-derived peptides on major rat burn injury-induced muscle atrophy. As protein nutrients have been previously implicated to play an important role in improving burn injury outcomes, optimized more readily absorbed small molecular weight soybean protein-derived peptides were evaluated. Thus, the quantity, sodium dodecyl sulfate polyacrylamide-gel electrophoresis patterns, molecular weight distribution, and composition of amino acids of the prepared peptides were analyzed, and a major full-thickness 30% total body surface area burn-injury rat model was utilized to assess the impact of supplementation with soybean protein-derived peptides on initial systemic inflammatory responses as measured by interferon-gamma (IFN-γ), chemokine (C-C motif) ligand 2 (CCL2, also known as MCP-1), chemokine (C-C motif) ligand 7 (CCL7, also known as MCP-3), and generation of muscle atrophy as measured by tibialis anterior muscle (TAM) weight relative to total body weight...
March 21, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29483826/aryl-hydrocarbon-receptor-activation-modulates-intestinal-epithelial-barrier-function-by-maintaining-tight-junction-integrity
#19
Min Yu, Qimeng Wang, Yuanhang Ma, Liangzi Li, Kun Yu, Zhicao Zhang, Guoqing Chen, Xiangsheng Li, Weidong Xiao, Pengyuan Xu, Hua Yang
Activation of Aryl hydrocarbon receptor (AhR) is involved in the control of intestinal mucosal homeostasis. Intestinal barrier dysfunction contributes to the development of many intestinal diseases, such as inflammatory bowel disease (IBD). In this study, we investigated the mechanisms of AhR activation in the maintenance of intestinal barrier function. Adult C57BL/6 mice were treated with dextran sulphate sodium (DSS) for 7 days, with or without 6-Formylindolo(3,2-b)carbazole (FICZ), a ligand of AhR. We found that AhR activation by FICZ attenuated the decreased TJ protein expression in the colonic mucosa of the DSS-induced mice...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29468178/retrograde-interferon-gamma-signaling-induces-major-histocompatibility-class-i-expression-in-human-induced-pluripotent-stem-cell-derived-neurons
#20
Benjamin D S Clarkson, Misha S Patel, Reghann G LaFrance-Corey, Charles L Howe
Objective: Injury-associated axon-intrinsic signals are thought to underlie pathogenesis and progression in many neuroinflammatory and neurodegenerative diseases, including multiple sclerosis (MS). Retrograde interferon gamma (IFN γ ) signals are known to induce expression of major histocompatibility class I (MHC I) genes in murine axons, thereby increasing the susceptibility of these axons to attack by antigen-specific CD8+ T cells. We sought to determine whether the same is true in human neurons...
February 2018: Annals of Clinical and Translational Neurology
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