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https://www.readbyqxmd.com/read/28237491/homozygosity-for-the-cd1e-02-allele-is-associated-with-a-resistance-to-plasmodium-falciparum-malaria-infection-in-gabonese-school-children
#1
Landry-Erik Mombo, Francine Ntoumi, Cyrille Bisseye, Rajendranath Ramasawmy, Pascal Millet, Ryad Tamouza
OBJECTIVE: To explore the possible association between polymorphisms in CD1 genes and both asymptomatic and mild Plasmodium falciparum infection. METHODS: Two clusters of 85 school children, from the village of Dienga (Gabon) were investigated. The first group was analysed for the prevalence and the multiplicity of asymptomatic P. falciparum infection, whereas the second group was screened for the frequency of malarial attacks. RESULTS: Our findings showed that homozygosity for the CD1E*02 allele was associated with a low frequency of malarial attacks...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28229279/immune-dysfunction-and-increased-oxidative-stress-state-in-diet-induced-obese-mice-are-reverted-by-nutritional-supplementation-with-monounsaturated-and-n-3-polyunsaturated-fatty-acids
#2
Caroline Hunsche, Oskarina Hernandez, Alina Gheorghe, Ligia Esperanza Díaz, Ascensión Marcos, Mónica De la Fuente
PURPOSE: Obesity is associated with impaired immune defences and chronic low levels of inflammation and oxidation. In addition, this condition may lead to premature aging. The aim of the study was to evaluate the effects of a nutritional supplementation with monounsaturated and n-3 polyunsaturated fatty acids on several functions and oxidative stress parameters in peritoneal immune cells of obese mice, as well as on the life span of these animals. METHODS: Obesity was induced in adult female ICR/CD1 by the administration of a high-fat diet (HFD) for 14 weeks...
February 23, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28222836/presumptive-spontaneous-lysosomal-storage-like-disease-in-a-crl-cd1-icr-mouse
#3
Krista M Hernon, Tiffany L Whitcomb, Lori Davis, Timothy K Cooper
A clinically unremarkable 4.5-mo-old female Crl:CD1(ICR) VAF/Elite mouse was euthanized for scheduled sentinel processing. Gross necropsy findings included significant hepatosplenomegaly and visceral lymphadenomegaly, resulting in a preliminary gross diagnosis of lymphoma. Histology revealed florid accumulations of large, 'foamy' macrophages present in the bone marrow, small intestines, and viscera including liver, spleen, lymph nodes, thymus, uterus, and ovaries. The cytoplasm of these cells was abundant, stained pale blue with Wright-Giemsa and was periodic acid-Schiff positive...
February 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28221804/semiconductor-seeded-nanorods-with-graded-composition-exhibiting-high-quantum-yield-high-polarization-and-minimal-blinking
#4
Ido Hadar, John Patrick Philbin, Yossef Efraim Panfil, Shany Neyshtadt, Itai Lieberman, Hagai Eshet, Sorin Lazar, Eran Rabani, Uri Banin
Seeded semiconductor nanorods represent a unique family of quantum confined materials that manifest characteristics of mixed dimensionality. They show polarized emission with high quantum yield and fluorescence switching under an electric field, features that are desirable for use in display technologies and other optical applications. So far, their robust synthesis has been limited mainly to CdSe/CdS heterostructures, thereby constraining the spectral tunability to the red region of the visible spectrum. Herein we present a novel synthesis of CdSe/Cd1-xZnxS seeded nanorods with radially graded composition that show bright and highly polarized green emission with minimal intermittency, as confirmed by ensemble and single nanorods optical measurements...
February 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28219986/functional-analysis-of-the-transmembrane-and-cytoplasmic-domains-of-pcdh15a-in-zebrafish-hair-cells
#5
Reo Maeda, Itallia V Pacentine, Timothy Erickson, Teresa Nicolson
Protocadherin 15 (PCDH15) is required for mechanotransduction in sensory hair cells as a component of the tip link. Isoforms of PCDH15 differ in their cytoplasmic domains (CD1, CD2, and CD3), but share the extracellular and transmembrane (TMD) domains, as well as an intracellular domain known as the common region (CR). In heterologous expression systems, both the TMD and CR of PCDH15 have been shown to interact with members of the mechanotransduction complex. The in vivo significance of these protein-protein interaction domains of PCDH15 in hair cells has not been determined...
February 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28215680/production-of-sperm-from-porcine-fetal-testicular-tissue-after-cryopreservation-and-grafting-into-nude-mice
#6
Hiroyuki Kaneko, Kazuhiro Kikuchi, Nguyen Thi Men, Michiko Nakai, Junko Noguchi, Naomi Kashiwazaki, Junya Ito
A major goal of testicular xenografting is to salvage germ cells from immature animals that cannot be used for reproduction and generate their offspring. In this study, we investigated whether porcine fetal testicular tissue would acquire the ability to produce sperm with full developmental competence after they had been cryopreserved and grafted into nude mice. Testicular fragments from fetuses at 35, 55 and 90 days postartificial insemination (dpi) were vitrified and stored in liquid nitrogen. Immediately after warming, testicular fragments at each fetal stage were transplanted under the back skin of castrated nude mice (Crlj:CD1-Foxn1(nu)) (35-, 55- and 90-dpi groups, respectively) (day 0 = grafting)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28214969/attached-and-suspended-denitrifier-communities-in-pristine-limestone-aquifers-harbor-high-fractions-of-potential-autotrophs-oxidizing-reduced-iron-and-sulfur-compounds
#7
M Herrmann, S Opitz, R Harzer, K U Totsche, K Küsel
Oxygen and nitrate availability as well as the presence of suitable organic or inorganic electron donors are strong drivers of denitrification; however, the factors influencing denitrifier abundance and community composition in pristine aquifers are not well understood. We explored the denitrifier community structure of suspended and attached groundwater microorganisms in two superimposed limestone aquifer assemblages with contrasting oxygen regime in the Hainich Critical Zone Exploratory (Germany). Attached communities were retrieved from freshly crushed parent rock material which had been exposed for colonization in two groundwater wells (12...
February 18, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28213294/a-low-cost-simplified-and-scaleable-pneumotachograph-and-face-mask-for-neonatal-mouse-respiratory-measurements
#8
Jenny J Sun, Roshan Nanu, Russell S Ray
INTRODUCTION: Neonatal respiratory disorders are a leading cause of perinatal mortality due to complications resulting from premature births and prenatal exposure to drugs of abuse, but optimal treatments for these symptoms are still unclear due to a variety of confounds and risk factors. Mouse models present an opportunity to study the underlying mechanisms and efficacy of potential treatments of these conditions with controlled variables. However, measuring respiration in newborn mice is difficult and commercial components are expensive and often require modification, creating a barrier and limiting our understanding of the short and long-term effects of birth complications on respiratory function...
February 15, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28205317/oxidative-stress-and-immunosenescence-in-spleen-of-obese-mice-can-be-reversed-by-2-hydroxyoleic-acid
#9
Alina Gheorghe, Fátima Pérez de Heredia, Caroline Hunsche, Noemí Redondo, Ligia Esperanza Díaz, Oskarina Hernández, Ascensión Marcos, Mónica De la Fuente
We aimed to investigate the effects of obesity on oxidative stress and leukocyte function in spleen of mice, and to assess whether supplementation with 2-hydroxyoleic acid (2-OHOA) or n-3 polyunsaturated fatty acids (PUFA) could reverse those effects. Female ICR/CD1 mice (8 weeks old, n = 24) received an obesogenic diet (22% fat for 4 weeks and 60% fat for 14 weeks). After 6 weeks, mice were split in three groups (n = 8/group): no supplementation, 2-OHOA supplementation (1500 mg kg(-1) ) and n-3 PUFA supplementation (EPA + DHA, 3000 mg kg(-1) diet)...
February 15, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28195949/a-preclinical-translational-study-of-the-cardioprotective-effects-of-plasma-derived-alpha-1-anti-trypsin-in-acute-myocardial-infarction
#10
Adolfo G Mauro, Eleonora Mezzaroma, Carlo Marchetti, Pratyush Narayan, Marco Del Buono, Marialessia Capuano, Andrea Prestamburgo, Simone Catapano, Fadi N Salloum, Antonio Abbate, Stefano Toldo
BACKGROUND: The area of myocardial infarction continues to expand for hours after reperfusion. The injured but viable myocardium may be salvaged if the signals leading to cell death are interrupted. Activation of the caspase-1 inflammasome in the heart shortly after ischemia-reperfusion contributes to the final infarct size. Plasma derived α-1 anti-trypsin (AAT) has shown to inhibit inflammasome formation in vitro and in vivo. To explore the potential translational clinical value of AAT as a therapeutic, we conducted a series of preclinical experiments designed to simulate clinically relevant scenarios...
February 13, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28179403/evaluation-of-pvceltos-as-a-pre-erythrocytic-p-vivax-vaccine
#11
Eduardo Alves, Ahmed M Salman, Fabiana Leoratti, Cesar Lopez-Camacho, Martha Eva Viveros-Sandoval, Amar Lall, Aadil El-Turabi, Martin F Bachmann, Adrian V S Hill, Chris J Janse, Shahid M Khan, Arturo Reyes-Sandoval
Four different vaccine platforms each targeting the human malaria parasite Plasmodium vivax cell-traversal protein for ookinetes and sporozoites (PvCelTOS) were generated and assessed for protective efficacy. These platforms consisted of a recombinant chimpanzee adenoviral vector ChAd63-PvCelTOS (Ad); a recombinant MVA-PvCelTOS (MVA); a bacteriophage Qβ-PvCelTOS virus-like particle (VLP); and recombinant PvCelTOS protein expressed in eukaryotic HEK293T cells (protein). Inbred BALB/c and outbred CD-1 mice were immunized using the following prime/boost regimens: Ad-MVA, Ad-VLP and Ad-protein...
February 8, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28178429/variations-in-histiocytic-differentiation-of-cell-lines-from-canine-cerebral-and-articular-histiocytic-sarcomas
#12
A Thongtharb, K Uchida, J K Chambers, H Nakayama
Two newly established canine histiocytic sarcoma (HS) cell lines, designated as PWC-HS01 and FCR-HS02, were obtained from brain and articular tumors, respectively. These 2 HS cell lines had phagocytic ability and modal chromosome aberrations. Although morphologic features of both HS cells were similar, immunocytochemical examinations revealed that the PWC-HS01 cell line expressed both dendritic cell (ie, S100, CD208, CD1, and CD4) and macrophage (ie, CD68, CD163, and CD204) markers. In contrast, the FCR-HS02 cell line was immunonegative for CD204 and CD68 but consistently positive for the dendritic cell markers...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28176522/stability-of-cd1-xznxoys1-y-quaternary-alloys-assessed-with-first-principles-calculations
#13
Joel B Varley, Xiaoqing He, Angus Rockett, Vincenzo Lordi
One route to decreasing the absorption in CdS buffer layers in Cu(In,Ga)Se2 and Cu2ZnSn(S,Se)4 thin-film photovoltaics is by alloying. Here we use first-principles calculations based on hybrid functionals to assess the energetics and stability of quaternary Cd, Zn, O, and S (Cd1-xZnxOyS1-y) alloys within a regular solution model. Our results identify that full miscibility of most Cd1-xZnxOyS1-y compositions and even binaries like Zn(O,S) is outside typical photovoltaic processing conditions. The results suggest that the tendency for phase separation of the oxysulfides may drive the nucleation of other phases such as sulfates that have been increasingly observed in oxygenated CdS and ZnS...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28169376/surface-passivation-of-cdse-quantum-dots-in-all-inorganic-amorphous-solid-by-forming-cd1-xznxse-shell
#14
Mengling Xia, Chao Liu, Zhiyong Zhao, Jing Wang, Changgui Lin, Yinsheng Xu, Jong Heo, Shixun Dai, Jianjun Han, Xiujian Zhao
CdSe quantum dots (QDs) doped glasses have been widely investigated for optical filters, LED color converter and other optical emitters. Unlike CdSe QDs in solution, it is difficult to passivate the surface defects of CdSe QDs in glass matrix, which strongly suppress its intrinsic emission. In this study, surface passivation of CdSe quantum dots (QDs) by Cd1-xZnxSe shell in silicate glass was reported. An increase in the Se/Cd ratio can lead to the partial passivation of the surface states and appearance of the intrinsic emission of CdSe QDs...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28154523/effects-of-systemic-metabolic-fuels-on-glucose-and-lactate-levels-in-the-brain-extracellular-compartment-of-the-mouse
#15
Alexandria Béland-Millar, Jeremy Larcher, Justine Courtemanche, Tina Yuan, Claude Messier
Classic neuroenergetic research has emphasized the role of glucose, its transport and its metabolism in sustaining normal neural function leading to the textbook statement that it is the necessary and sole metabolic fuel of the mammalian brain. New evidence, including the Astrocyte-to-Neuron Lactate Shuttle hypothesis, suggests that the brain can use other metabolic substrates. To further study that possibility, we examined the effect of intraperitoneally administered metabolic fuels (glucose, fructose, lactate, pyruvate, ß-hydroxybutyrate, and galactose), and insulin, on blood, and extracellular brain levels of glucose and lactate in the adult male CD1 mouse...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28153096/hiv-1-conserved-mosaics-delivered-by-regimens-with-integration-deficient-dc-targeting-lentiviral-vector-induce-robust-t-cells
#16
Edmund G Wee, Beatrice Ondondo, Peter Berglund, Jacob Archer, Andrew J McMichael, David Baltimore, Jan H Ter Meulen, Tomáš Hanke
To be effective against HIV type 1 (HIV-1), vaccine-induced T cells must selectively target epitopes, which are functionally conserved (present in the majority of currently circulating and reactivated HIV-1 strains) and, at the same time, beneficial (responses to which are associated with better clinical status and control of HIV-1 replication), and rapidly reach protective frequencies upon exposure to the virus. Heterologous prime-boost regimens using virally vectored vaccines are currently the most promising vaccine strategies; nevertheless, induction of robust long-term memory remains challenging...
February 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28127028/natural-killer-t-cells-in-atherosclerosis
#17
REVIEW
Godfrey S Getz, Catherine A Reardon
Atherosclerosis is a chronic inflammatory disorder that develops in response to hyperlipidaemia. Cells from both the innate and adaptive immune systems contribute to the development of atherosclerotic lesions. The role of natural killer T (NKT) cells in response to microbial pathogens and inflammatory disorders such as atherosclerosis has received increasing attention in the past 10-15 years. Endogenous self-lipid antigens and exogenous lipid antigens, including those on microorganisms can activate NKT cells...
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28116384/effect-of-zn-substitution-on-the-magnetic-and-magnetocaloric-properties-of-cd1-xznxcr2se4-spinel
#18
M Bouhbou, R Moubah, W Belayachi, A Belayachi, H Lassri
The influence of Zn substitution on the magnetic and magnetocaloric properties of Cd1-xZnxCr2Se4 (0.35 ≤ x ≤ 0.45) spinel was investigated. All the samples exhibited two successive magnetic transitions associated with the reentrant spin glass at a freezing temperature (Tf) and Curie temperature (TC). It was demonstrated that Tf changed slightly with the Zn content; however, the TC value decreased with increasing Zn content due to the decrease of lattice constant. The magnetic entropy variation (-ΔSM) was found to exhibit two maxima at TC and Tf, which have an opposite trend as a function of Zn content...
January 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28115591/type-ii-nkt-cells-and-their-emerging-role-in-health-and-disease
#19
REVIEW
Madhav V Dhodapkar, Vipin Kumar
NKT cells recognize lipid Ags presented by a class I MHC-like molecule CD1d, a member of the CD1 family. Although most initial studies on NKT cells focused on a subset with semi-invariant TCR termed invariant NKT cells, the majority of CD1d-restricted lipid-reactive human T cells express diverse TCRs and are termed type II NKT cells. These cells constitute a distinct population of circulating and tissue-resident effector T cells with immune-regulatory properties. They react to a growing list of self- as well as non-self-lipid ligands, and share some properties with both invariant NKT and conventional T cells...
February 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28106145/cd1-and-cd1-porcine-blood-dendritic-cells-are-enriched-for-the-orthologues-of-the-two-major-mammalian-conventional-subsets
#20
Jane C Edwards, Helen E Everett, Miriam Pedrera, Helen Mokhtar, Emanuele Marchi, Ferran Soldevila, Daryan A Kaveh, Philip J Hogarth, Helen L Johns, Javier Nunez-Garcia, Falko Steinbach, Helen R Crooke, Simon P Graham
Conventional dendritic cells (cDC) are professional antigen-presenting cells that induce immune activation or tolerance. Two functionally specialised populations, termed cDC1 and cDC2, have been described in humans, mice, ruminants and recently in pigs. Pigs are an important biomedical model species and a key source of animal protein; therefore further understanding of their immune system will help underpin the development of disease prevention strategies. To characterise cDC populations in porcine blood, DC were enriched from PBMC by CD14 depletion and CD172a enrichment then stained with lineage mAbs (Lin; CD3, CD8α, CD14 and CD21) and mAbs specific for CD172a, CD1 and CD4...
January 20, 2017: Scientific Reports
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