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https://www.readbyqxmd.com/read/29237773/a-subset-of-human-autoreactive-cd1c-restricted-t-cells-preferentially-expresses-trbv4-1-tcrs
#1
Tingxi Guo, Ming Yin Koo, Yuki Kagoya, Mark Anczurowski, Chung-Hsi Wang, Kayoko Saso, Marcus O Butler, Naoto Hirano
In humans, a substantial portion of T cells recognize lipids presented by the monomorphic CD1 proteins. Recent studies have revealed the molecular basis of mycobacterial lipid recognition by CD1c-restricted T cells. Subsets of CD1c-restricted T cells recognize self-lipids in addition to foreign lipids, which may have implications in human diseases involving autoimmunity and malignancy. However, the molecular identity of these self-reactive T cells remains largely elusive. In this study, using a novel CD1c+ artificial APC (aAPC)-based system, we isolated human CD1c-restricted autoreactive T cells and characterized them at the molecular level...
December 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29220154/set-of-multifunctional-azo-functionalized-semiconducting-cd-ii-mofs-showing-photoswitching-property-and-selective-co2-adsorption
#2
Dilip Kumar Maity, Arka Dey, Saheli Ghosh, Arijit Halder, Partha Pratim Ray, Debajyoti Ghoshal
Syntheses, structural characterizations, photoluminescence, and adsorption properties of three new azo-functionalized Cd(II)-MOFs, namely, {[Cd(azbpy)(msuc)]·2.5(H2O)}n (2), {[Cd(azbpy)(mglu)]·5(H2O)}n (3), and {[Cd1.5(azbpy)2(glu)]·(NO3)·MeOH}n (4) [where msuc2- = methylsuccinate; mglut2- = methylglutarate; glut2- = glutarate; azbpy = 4,4'-azobispyridine] have been reported. The compounds show different structures only with the variation of aliphatic dicarboxylates. The photoswitching behavior for the above-mentioned newly synthesized Cd(II)-MOFs along with one of our previously reported other azo-functionalized Cd(II)-MOF, namely, {[Cd(azbpy)(suc)]·2(H2O)}n (1), has been studied extensively...
December 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29218015/trimethylamine-n-oxide-supplementation-abolishes-the-cardioprotective-effects-of-voluntary-exercise-in-mice-fed-a-western-diet
#3
Hongqi Zhang, Jian Meng, Haiyan Yu
Excessive consumption of western diet (WD) induces obesity, resulting in cardiac dysfunction. Voluntary exercise ameliorates WD-induced obesity, but its effect on cardiac dysfunction remains unclear. Recent evidence suggests that elevated trimethylamine N-oxide (TMAO), a gut microbe-derived metabolite, can impair cardiac function in WD-induced obesity. We hypothesized that cardiac dysfunction in WD-induced obesity would be prevented by voluntary exercise but abolished by TMAO supplementation. Male CD1 mice fed a WD were assigned to sedentary, exercise or exercise with TMAO treatment for 8 weeks...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29207574/novel-carbazole-skeleton-based-photoinitiators-for-led-polymerization-and-led-projector-3d-printing
#4
Assi Al Mousawi, Patxi Garra, Frédéric Dumur, Thanh-Tuan Bui, Fabrice Goubard, Joumana Toufaily, Tayssir Hamieh, Bernadette Graff, Didier Gigmes, Jean Pierre Fouassier, Jacques Lalevée
Radical chemistry is a very convenient way to produce polymer materials. Here, an application of a particular photoinduced radical chemistry is illustrated. Seven new carbazole derivatives Cd1-Cd7 are incorporated and proposed as high performance near-UV photoinitiators for both the free radical polymerization (FRP) of (meth)acrylates and the cationic polymerization (CP) of epoxides utilizing Light Emitting Diodes LEDs @405 nm. Excellent polymerization-initiating abilities are found and high final reactive function conversions are obtained...
December 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29204304/langerhans-cell-histiocytosis-a-diagnostic-challenge-in-the-oral-cavity
#5
Mehmet Ali Altay, Alper Sindel, Öznur Özalp, Burak Kocabalkan, İrem Hicran Özbudak, Ramazan Erdem, Ozan Salim, Dale A Baur
Background: Langerhans cell histiocytosis (LCH) is a rare disorder of the reticuloendothelial system with unknown etiology. This report aims to present a case of LCH with diffuse involvement of the oral cavity and to raise awareness of the distinguishing features of this diagnostically challenging entity. Case Report: A 26-year-old male patient presented with complaints of teeth mobility, intense pain, and difficulty in chewing. Intraoral and radiological examinations revealed generalized gingival hyperplasia and severe teeth mobility with widespread alveolar bone loss...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/29187314/what-is-stressful-for-females-differential-effects-of-unpredictable-environmental-or-social-stress-in-cd1-female-mice
#6
Harold Dadomo, Laura Gioiosa, Jenny Cigalotti, Graziano Ceresini, Stefano Parmigiani, Paola Palanza
Stressful life events are a major factor in the etiology of several diseases, such as cardiovascular, inflammatory and psychiatric disorders (i.e., depression and anxiety), with the two sexes greatly differing in vulnerability. In humans and other animals, physiological and behavioral responses to stress are strongly dependent on gender, and conditions that are stressful for males are not necessarily stressful for females. Hence the need of an animal model of social chronic stress specifically designed for females...
November 26, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29177007/a-simplified-microwave-based-motion-detector-for-home-cage-activity-monitoring-in-mice
#7
Andreas Genewsky, Daniel E Heinz, Paul M Kaplick, Kasyoka Kilonzo, Carsten T Wotjak
Background: Locomotor activity of rodents is an important readout to assess well-being and physical health, and is pivotal for behavioral phenotyping. Measuring homecage-activity with standard and cost-effective optical methods in mice has become difficult, as modern housing conditions (e.g. individually ventilated cages, cage enrichment) do not allow constant, unobstructed, visual access. Resolving this issue either makes greater investments necessary, especially if several experiments will be run in parallel, or is at the animals' expense...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/29170618/bi2se3-van-der-waals-virtual-substrates-for-ii-vi-heterostructures
#8
Thor Axtmann Garcia, Vasilios Deligiannakis, Candice Forrester, Ido Levy, Maria C Tamargo
We report on the growth and characterization of optical quality multiple quantum well structures of Zn x Cd1-x Se/Zn x Cd y Mg1-x-y Se on an ultra-thin Bi2Se3/CdTe virtual substrate on c-plane Al2O3 (sapphire). Excellent quality highly oriented films grown along the (111) direction were achieved as evidenced by reflection high energy electron diffraction and X-ray diffraction studies. We also observed room temperature and 77 K photoluminescence emission with peak energies at 77 K of 2.407 eV and linewidths of 56 meV comparable to those achieved on structures grown on InP...
November 2017: Physica Status Solidi. B, Basic Solid State Physics: PSS
https://www.readbyqxmd.com/read/29152228/cd1-from-molecules-to-diseases
#9
REVIEW
D Branch Moody, Sara Suliman
The human cluster of differentiation (CD)1 system for antigen display is comprised of four types of antigen-presenting molecules, each with a distinct functional niche: CD1a, CD1b, CD1c, and CD1d. Whereas CD1 proteins were thought solely to influence T-cell responses through display of amphipathic lipids, recent studies emphasize the role of direct contacts between the T-cell receptor and CD1 itself. Moving from molecules to diseases, new research approaches emphasize human CD1-transgenic mouse models and the study of human polyclonal T cells in vivo or ex vivo in disease states...
2017: F1000Research
https://www.readbyqxmd.com/read/29142736/strain-differences-in-cuprizone-induced-demyelination
#10
Qili Yu, Ryan Hui, Jiyoung Park, Yangyang Huang, Alexander W Kusnecov, Cheryl F Dreyfus, Renping Zhou
Background: Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide. In terms of research in MS pathology, the cuprizone toxicity model is widely used. Here we investigated the contribution of genetic differences in response to cuprizone-induced demyelination in two genetically different mouse strains: CD1 and C57BL/6. Results: We demonstrate that exposure to a diet containing 0...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29133126/the-role-of-urotensin-ii-and-its-receptors-in-sepsis-induced-lung-injury-under-diabetic-conditions
#11
Rustem Anil Ugan, Elif Cadirci, Zekai Halici, Erdem Toktay, Irfan Cinar
This study aimed to investigate the potential role of urotensin-II receptors in sepsis-induced lung injury in diabetic mice using urotensin-II receptor agonists and antagonists. A total of 110 male CD1 mice were used in this study. Diabetes was induced by 200mg/kg streptozotocin. One month after diabetes induction, the cecal ligation and puncture-induced polymicrobial sepsis model was applied in the diabetic and non-diabetic mice. Low and high doses of human urotensin-II agonist (HU-II) and antagonist (palosuran) were administered one hour after sepsis induction...
November 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29130802/oral-immunotherapy-using-polymeric-nanoparticles-loaded-with-peanut-proteins-in-a-murine-model-of-fatal-anaphylaxis
#12
Carlos Gamazo, Maddi García-Azpíroz, Juliana De Souza Rebouças, Gabriel Gastaminza, Marta Ferrer, Juan M Irache
BACKGROUND: Peanut allergy is the most common cause of anaphylaxis and food-related death. However, there is currently no approved immunotherapy treatment. Hence, this warrants the need for relevant and convenient animal models to test for adequate immunotherapies. MATERIALS & METHODS: In this study, we compared three mouse strains: CD1, BALB/c and C57, to select a model of peanut allergy. After that, we conducted then a therapeutic study using an immunogenic peanut extract encapsulated in nanoparticles made with polymer Gantrez(®) following the solvent displacement method...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29129023/pathomechanisms-of-contact-sensitization
#13
REVIEW
Philipp R Esser, Stefan F Martin
Contact sensitization is the initial process involved in the development of an allergic reaction to xenobiotic environmental substances. Here, we briefly describe the differences between irritant and allergic contact dermatitis. Then, we highlight the essential steps involved in the development of an ACD reaction, i.e., the protein binding of haptens, genetic factors influencing the penetration of sensitizers into the skin, the different mechanisms driving the initial development of an inflammatory cytokine micromilieu enabling the full maturation of dendritic cells, the role of pre- and pro-haptens, antigen presentation and T cell activation via MHC and CD1 molecules, dendritic cell (DC) migration, and potential LC contribution as well as the different T cell subsets involved in ACD...
November 11, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29128611/intrathecal-administration-of-antisense-oligonucleotide-against-p38%C3%AE-but-not-p38%C3%AE-map-kinase-isoform-reduces-neuropathic-and-postoperative-pain-and-tlr4-induced-pain-in-male-mice
#14
Xin Luo, Bethany Fitzsimmons, Apoorva Mohan, Linlin Zhang, Niccolo Terrando, Holly Kordasiewicz, Ru-Rong Ji
p38 mitogen-activated protein kinase (MAPK) consists of two major isoforms: p38α and p38β; however, it remains unclear which isoform is more important for chronic pain development. Recently, we developed potent, long-lasting, and p38 MAPK subtype-specific antisense oligonucleotides (ASOs). We examined the therapeutic effects of isoform-specific ASOs in several chronic pain models following single intrathecal injection (300 μg/10 μl) in CD1 mice. In the chronic constriction injury (CCI) model, p38α MAPK ASO, given on post-operative day 5, reduced CCI-induced mechanical allodynia in male but not female mice...
November 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29125985/cadmium-toxicity-and-its-amelioration-by-kinetin-in-tomato-seedlings-vis-%C3%A3-vis-ascorbate-glutathione-cycle
#15
Shikha Singh, Anita Singh, Prabhat Kumar Srivastava, Sheo Mohan Prasad
The supplementation of plant hormones may enhance the tolerance capacity of plants against certain environmental stresses by increasing their physiological functioning and detoxification capacity. To answer the question that whether a phytohormone 'kinetin' (KN, 6-furfuylaminopurine), one of the artificial cytokinins could ameliorate the cadmium induced toxicity in tomato seedlings, the effect of KN was assessed in differentially cadmium (Cd1: 3mgkg(-1) sand and Cd2: 9mgkg(-1) sand) intoxicated tomato seedlings by estimating the changes in reactive oxygen species (ROS, viz...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29113870/molecular-features-of-lipid-based-antigen-presentation-by-group-1-cd1-molecules
#16
REVIEW
Jérôme Le Nours, Adam Shahine, Stephanie Gras
Lipids are now widely considered to play a variety of important roles in T-cell mediated immunity, including serving as antigens. Lipid-based antigens are presented by a specialised group of glycoproteins termed CD1. In humans, three classes of CD1 molecules exist: group 1 (CD1a, CD1b, CD1c), group 2 (CD1d), and group 3 (CD1e). While CD1d-mediated T-cell immunity has been extensively investigated, we have only recently gained insights into the structure and function of group 1 CD1 molecules. Structural studies have revealed how lipid-based antigens are presented by group 1 CD1 molecules, as well as shedding light on the molecular requirements for T-cell recognition...
November 4, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29104538/chronic-treatment-with-fluoxetine-induces-sex-dependent-analgesic-effects-and-modulates-hdac2-and-mglu2-expression-in-female-mice
#17
Magda Zammataro, Sara Merlo, Massimo Barresi, Carmela Parenti, Huijuan Hu, Maria A Sortino, Santina Chiechio
Gender and sex differences in pain recognition and drug responses have been reported in clinical trials and experimental models of pain. Among antidepressants, contradictory results have been observed in patients treated with selective serotonin reuptake inhibitors (SSRIs). This study evaluated sex differences in response to the SSRI fluoxetine after chronic administration in the mouse formalin test. Adult male and female CD1 mice were intraperitoneally injected with fluoxetine (10 mg/kg) for 21 days and subjected to pain assessment...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29100724/expression-of-the-gm2-activator-protein-in-mouse-testis
#18
Yu-Teh Li, Su-Chen Li, I-Li Chen
The GM2-activator protein (GM2-AP), revealed by Li et al. in 1973 in human liver, was initially identified as a protein cofactor that stimulated β-hexosaminidase A to hydrolyze N-acetylgalactosamine from GM2 ganglioside. This cofactor was found to be missing in human variant AB Tay-Sachs disease. Over the years, the GM2-AP has also been shown to be involved in kidney vesicular transport, lipid presentation by CD1 molecule to T-cells, and interaction of human sperm with zona pellucida. Since the expression of the GM2-AP via mRNA detection in mouse tissues was found to be the highest in testis, we became interested in the localization of the GM2-AP at cellular level in mouse testis during spermatogenesis...
October 31, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29098186/chronic-adolescent-%C3%AE-9-tetrahydrocannabinol-treatment-of-male-mice-leads-to-long-term-cognitive-and-behavioral-dysfunction-which-are-prevented-by-concurrent-cannabidiol-treatment
#19
Michelle Murphy, Sierra Mills, Joanna Winstone, Emma Leishman, Jim Wager-Miller, Heather Bradshaw, Ken Mackie
Introduction: The high prevalence of adolescent cannabis use, the association between this use and later psychiatric disease, and increased access to high-potency cannabis highlight the need for a better understanding of the long-term effects of adolescent cannabis use on cognitive and behavioral outcomes. Furthermore, increasing Δ(9)-tetrahydrocannabinol (THC) in high-potency cannabis is accompanied by a decrease in cannabidiol (CBD), thus an understanding of the interactions between CBD and THC in the neurodevelopmental effects of THC is also important...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29079502/inhibiting-12-15-lipoxygenase-to-treat-acute-stroke-in-permanent-and-tpa-induced-thrombolysis-models
#20
H Karatas, Joo Eun Jung, E H Lo, K van Leyen
12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, LOXBlock-1(LB1), in mice using a FeCl3-induced permanent distal MCAO model and FeCl3-induced ischemia/thrombolysis with tPA. In order to induce permanent distal MCAO, 30% FeCl3 was used in C57BL6 mice. LB1 or DMSO treatments were applied intraperitoneally 2hrs following MCAO. For FeCl3-induced ischemia/thrombolysis experiments, 10% FeCl3 was preferred so as to obtain reperfusion with tPA in CD1 mice...
October 24, 2017: Brain Research
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