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https://www.readbyqxmd.com/read/28434208/dietary-interventions-for-adults-with-chronic-kidney-disease
#1
REVIEW
Suetonia C Palmer, Jasjot K Maggo, Katrina L Campbell, Jonathan C Craig, David W Johnson, Bernadet Sutanto, Marinella Ruospo, Allison Tong, Giovanni Fm Strippoli
BACKGROUND: Dietary changes are routinely recommended in people with chronic kidney disease (CKD) on the basis of randomised evidence in the general population and non-randomised studies in CKD that suggest certain healthy eating patterns may prevent cardiovascular events and lower mortality. People who have kidney disease have prioritised dietary modifications as an important treatment uncertainty. OBJECTIVES: This review evaluated the benefits and harms of dietary interventions among adults with CKD including people with end-stage kidney disease (ESKD) treated with dialysis or kidney transplantation...
April 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28433375/mosaicism-between-trophectoderm-and-inner-cell-mass
#2
REVIEW
Antonio Capalbo, Laura Rienzi
Defining the actual incidence and prevalence of mosaicism in human blastocysts still remains a difficult task. The small amount of evidence generated by animal and human studies does not support the existence of mechanisms involved in developmental arrest, clonal depletion, or aneuploidy rescue for abnormal cells in euploid/aneuploid embryos during preimplantation development. However, studies in humans are mainly descriptive and lack functional evidence. Understanding the biological mechanisms that beset preimplantation differentiation holds the potential to reveal the role of aneuploidies and gene dosage imbalances in cell fate decision, providing important clues on the origin and evolution of embryonic mosaicism...
April 19, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28432566/four-new-species-of-dactylogyrus-diesing-1850-monogenea-dactylogyridae-parasitising-the-gills-of-northern-moroccan-luciobarbus-heckel-cyprinidae-morphological-and-molecular-characterisation
#3
Imane Rahmouni, Eva Řehulková, Antoine Pariselle, Ouafae Berrada Rkhami, Andrea Šimková
Four new species of Dactylogyrus Diesing, 1850 are described from the gills of three species of Luciobarbus Heckel collected from various hydrographical basins in northern Morocco: Dactylogyrus scorpius n. sp. from Luciobarbus rifensis Doadrio, Casal-Lopez & Yahyaoui; D. benhoussai n. sp. from L. moulouyensis Pellegrin; and D. varius n. sp. and D. falsiphallus n. sp. from L. maghrebensis Doadrio, Perea & Yahyaoui. The descriptions of the new species are confirmed by molecular data (partial 18S rDNA, ITS1, and partial 28S rDNA sequences)...
April 21, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28431117/seeking-certainty-judicial-approaches-to-the-non-treatment-of-minimally-conscious-patients
#4
Richard Huxtable, Giles Birchley
A modest, but growing, body of case law is developing around the (non-)treatment of patients in the minimally conscious state. We sought to explore the approaches that the courts take to these decisions. Using the results of a qualitative analysis, we identify five key features of the rulings to date. First, the judges appear keen to frame the cases in such a way that these are rightly matters for judicial determination. Secondly, the judges appraise the types and forms of expertise that enter the courtroom, seeming to prefer the 'objective' and 'scientific', and particularly the views of the doctors...
April 18, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28430767/are-steroids-effective-in-toxic-epidermal-necrolysis-and-stevens-johnson-syndrome
#5
Rodrigo Meza, Gabriel Rada, Pablo Varas
Toxic epidermal necrolysis and Stevens-Johnson syndrome are severe adverse skin reactions to medications and infections. Steroids are described as a therapeutic alternative, but their use is still controversial. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple information sources. We identified four systematic reviews including 11 primary studies answering the question of interest. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
April 5, 2017: Medwave
https://www.readbyqxmd.com/read/28428036/giantcell-tumor-of-tendon-sheath-open-surgery-or-arthroscopic-synovectomy-a-systematic-review-of-the-literature
#6
REVIEW
Thibaut Noailles, Kevin Brulefert, Sylvain Briand, Pierre Marie Longis, Kevin Andrieu, Antoine Chalopin, François Gouin
PURPOSE: Giantcell tumor of tendon sheath(GCTTS)formelyknowned as pigmented villonodular synovitis (PVNS) is a benign, locally aggressive, proliferative disorder of the synovium involving a joint, bursa, or tendon sheath. Treatment ofGCTTSinvolves early surgical resection to limit articular destruction and the risk of recurrence. Synovectomy remains the treatment of choice forGCTTSbut without clear consensus to make an open or arthroscopic synovectomy andno certainty on the responsibility of surgery in the evolution towards the degenerative osteoarthritis...
April 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28424273/certainty-of-genuine-treatment-increases-drug-responses-among-intellectually-disabled-patients
#7
Karin B Jensen, Irving Kirsch, Moa Pontén, Annelie Rosén, Kathy Yang, Randy L Gollub, Vincent des Portes, Ted J Kaptchuk, Aurore Curie
OBJECTIVE: To determine the placebo component of treatment responses in patients with intellectual disability (ID). METHODS: A statistical meta-analysis comparing bias-corrected effect sizes (Hedges g) of drug responses in open-label vs placebo-controlled clinical trials was performed, as these trial types represent different certainty of receiving genuine treatment (100% vs 50%). Studies in fragile X, Down, Prader-Willi, and Williams syndrome published before June 2015 were considered...
April 19, 2017: Neurology
https://www.readbyqxmd.com/read/28421728/oral-pigmentations-in-physiologic-conditions-post-inflammatory-affections-and-systemic-diseases
#8
Martina Lambertini, Annalisa Patrizi, Giulia M Ravaioli, Emi Dika
Melanocytes are found throughout the oral mucosa but usually go unnoticed because of their relatively low level of pigment production. When focally or generally active in pigment production or proliferation they may be responsible for several affections in the oral mucosae ranging from physiologic pigmentation, systemic diseases to malignant neoplasms. The diagnosis of oral pigmentations (OP) is usually challenging for the physician, but a careful examination of the oral cavity may reveal the first manifestation of underlying systemic diseases...
April 19, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28421696/assessing-causality-in-drug-policy-analyses-how-useful-are-the-bradford-hill-criteria-in-analysing-take-home-naloxone-programs
#9
Anna Olsen, David McDonald, Simon Lenton, Paul M Dietze
The Bradford Hill criteria for assessing causality are useful in assembling evidence, including within complex policy analyses. In this paper, we argue that the implementation of take-home naloxone (THN) programs in Australia and elsewhere reflects sensible, evidence-based public health policy, despite the absence of randomised controlled trials. However, we also acknowledge that the debate around expanding access to THN would benefit from a careful consideration of causal inference and health policy impact of THN program implementation...
April 18, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28420178/how-older-adults-and-their-families-perceive-family-talk-about-aging-related-eol-issues-a-dialectical-analysis
#10
Nichole Egbert, Jeffrey T Child, Mei-Chen Lin, Carol Savery, Tammy Bosley
For older adults, approaching end-of-life (EOL) brings unique transitions related to family relationships. Unfortunately, most families greatly underestimate the need to discuss these difficult issues. For example, parents approaching EOL issues often struggle with receiving assistance from others, avoiding family conflict, and maintaining their sense of personhood. In addition, discussions of EOL issues force family members to face their parents' mortality, which can be particularly difficult for adult children to process emotionally...
April 17, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28414524/a-standardized-diagnostic-ontology-for-fibrotic-interstitial-lung-disease-an-international-working-group-perspective
#11
Christopher J Ryerson, Tamera J Corte, Joyce S Lee, Luca Richeldi, Simon L F Walsh, Jeffrey L Myers, Juergen Behr, Vincent Cottin, Sonye K Danoff, Kevin R Flaherty, David J Lederer, David A Lynch, Fernando J Martinez, Ganesh Raghu, William D Travis, Zarir Udwadia, Athol U Wells, Harold R Collard
Diagnosing fibrotic interstitial lung disease (ILD) requires multidisciplinary integration of clinical, radiological, and pathological features with assignment of a consensus classification. The current approach lacks a standardized ontology and therefore results in diagnostic heterogeneity. The objectives of this international working group perspective are to describe limitations of the current approach to fibrotic ILD diagnosis and to develop an ontological framework for standardizing the diagnostic classification...
April 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28412464/grade-equity-guidelines-1-health-equity-in-guideline-development-introduction-and-rationale
#12
Vivian A Welch, Elie A Akl, Gord Guyatt, Kevin Pottie, Javier Eslava-Schmalbach, Mohammed T Ansari, Hans de Beer, Matthias Briel, Tony Dans, Inday Dans, Monica Hultcrantz, Janet Jull, Srinivasa Vittal Katikireddi, Joerg Meerpohl, Rachael Morton, Annhild Mosdol, Jennifer Petkovic, Holger Schünemann, Ravi Sharaf, Jasvinder Singh, Roger Stanev, Thomy Tonia, Mario Tristan, Sigurd Vitols, Joseph Watine, Peter Tugwell
OBJECTIVES: This paper introduces the rationale and methods for explicitly considering health equity in the GRADE methodology for development of clinical, public health and health system guidelines. STUDY DESIGN AND SETTING: guidance for guideline development STUDY DESIGN AND SETTING: We searched for guideline methodology papers, conceptual papers about health equity and examples of guidelines which considered health equity explicitly. We held three meetings with GRADE working group members, and invited comments from the GRADE working group listserve RESULTS: We developed three papers on incorporating equity considerations into the overall approach to guideline development, rating certainty and assembling the evidence base and evidence to decision/recommendation...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28405374/evidence-for-a-genetic-sex-determination-in-cnidaria-the-mediterranean-red-coral-corallium-rubrum
#13
M Pratlong, A Haguenauer, S Chenesseau, K Brener, G Mitta, E Toulza, M Bonabaud, S Rialle, D Aurelle, P Pontarotti
Sexual reproduction is widespread among eukaryotes, and the sex-determining processes vary greatly among species. While genetic sex determination (GSD) has been intensively described in bilaterian species, no example has yet been recorded among non-bilaterians. However, the quasi-ubiquitous repartition of GSD among multicellular species suggests that similar evolutionary forces can promote this system, and that these forces could occur also in non-bilaterians. Studying sex determination across the range of Metazoan diversity is indeed important to understand better the evolution of this mechanism and its lability...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28400904/extensive-mobile-thrombus-of-the-internal-carotid-discovered-after-intravenous-thrombolysis-what-do-i-do-now
#14
Eugene L Scharf, Jennifer E Fugate, Sara E Hocker
This case report describes a rare presentation of ischemic stroke secondary to an extensive internal carotid artery thrombus, subsequent therapeutic dilemma, and clinical management. A 58-year-old man was administered intravenous (IV) thrombolysis for right middle cerebral artery territory ischemic stroke symptoms. A computed tomography angiogram of the head and neck following thrombolysis showed a longitudinally extensive internal carotid artery thrombus originating at the region of high-grade calcific stenosis...
April 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28400903/neurosarcoidosis-presenting-with-recurrent-strokes-a-case-report-and-literature-review
#15
Naheed Raza, Karisa C Schreck
Neurosarcoidosis is a rare but important cause of stroke as it is treatable. Cases reported thus far have primarily been in young people who are relatively healthy. Here we report the case of a 73-year-old woman presenting with recurrent strokes and high-grade intracranial stenosis caused by probable neurosarcoidosis. This is unique as neurosarcoidosis is not usually considered as an etiology for recurrent strokes in our patient's age-group. We review and categorize published cases of neurosarcoidosis causing stroke and describe a classification scheme for certainty of diagnosis...
April 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28398692/seven-versus-10-days-antibiotic-therapy-for-culture-proven-neonatal-sepsis-a-randomised-controlled-trial
#16
Smriti Rohatgi, Pooja Dewan, Mohammad Moonis Akbar Faridi, Ashwani Kumar, Rajeev Kumar Malhotra, Prerna Batra
AIM: Optimal duration of parenteral antibiotics for treating neonatal sepsis ranges from 7-14 days. We compared the efficacy of 7 versus 10 days duration of intravenous antibiotics for neonatal septicaemia. METHODS: We randomised blood culture-proven septic neonates (≥32 weeks and birth weight ≥1.5 kg) to receive either 7 or 10 days duration of intravenous antibiotics. We followed up neonates upto 28 days after stopping antibiotics for treatment failure defined by reappearance of clinical sepsis with a blood culture growing the same organism as cultured earlier, or in the absence of a positive culture, the presence of C-reactive protein and as adjudicated by an expert committee...
April 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28397180/measurement-of-mbf-by-pet-is-ready-for-prime-time-as-an-integral-part-of-clinical-reports-in-diagnosis-and-risk-assessment-of-patients-with-known-or-suspected-cad-for-prime-time-not-yet-need-impact-and-certainty
#17
Heinrich Schelbert
No abstract text is available yet for this article.
April 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28394955/-perceptions-about-the-elisa-test-of-people-diagnosed-at-the-aids-stage
#18
Paola Carrasco A, Alejandra X Araya G, Paula Vega, María Teresa Urrutia S, Miriam Rubio A, Claudio Trujillo G, María Jesús Lira S
BACKGROUND: The delay in the diagnosis of AIDS results in higher treatment costs. AIM: To reveal the experiences of people who were diagnosed in the AIDS stage about the access to the ELISA test. MATERIAL AND METHODS: In depth interviews were carried out to 15 participants from public hospitals who were in the AIDS stage at the moment of the diagnosis. The main questions asked were about the motivations to take the test, the barriers found and the help received from the health care personnel...
November 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28392995/a-computer-aided-diagnostic-system-for-kidney-disease
#19
Farzad Firouzi Jahantigh, Behnam Malmir, Behzad Aslani Avilaq
BACKGROUND: Disease diagnosis is complicated since patients may demonstrate similar symptoms but physician may diagnose different diseases. There are a few number of investigations aimed to create a fuzzy expert system, as a computer aided system for disease diagnosis. METHODS: In this research, a cross-sectional descriptive study conducted in a kidney clinic in Tehran, Iran in 2012. Medical diagnosis fuzzy rules applied, and a set of symptoms related to the set of considered diseases defined...
March 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28392363/stent-as-bridge-to-surgery-for-left-sided-malignant-colonic-obstruction-reduces-adverse-events-and-stoma-rate-compared-with-emergency-surgery-results-of-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Alberto Arezzo, Roberto Passera, Giacomo Lo Secco, Mauro Verra, Marco Augusto Bonino, Eduardo Targarona, Mario Morino
BACKGROUND AND AIMS: Twenty years after the first description of the technique, the debate is still open on role of self-expandable metallic stent (SEMS) placement as a bridge to elective surgery for symptomatic left-sided malignant colonic obstruction. The aim was to compare morbidity rates after colonic stenting bridge to surgery (SBTS) versus emergency surgery (ES) for left-sided malignant obstruction. METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) on SBTS or ES for acute symptomatic malignant left-sided large bowel obstruction...
April 6, 2017: Gastrointestinal Endoscopy
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