keyword
MENU ▼
Read by QxMD icon Read
search

Certainty

keyword
https://www.readbyqxmd.com/read/28545155/rapid-diagnostic-tests-for-typhoid-and-paratyphoid-enteric-fever
#1
REVIEW
Lalith Wijedoru, Sue Mallett, Christopher M Parry
BACKGROUND: Differentiating both typhoid (Salmonella Typhi) and paratyphoid (Salmonella Paratyphi A) infection from other causes of fever in endemic areas is a diagnostic challenge. Although commercial point-of-care rapid diagnostic tests (RDTs) for enteric fever are available as alternatives to the current reference standard test of blood or bone marrow culture, or to the widely used Widal Test, their diagnostic accuracy is unclear. If accurate, they could potentially replace blood culture as the World Health Organization (WHO)-recommended main diagnostic test for enteric fever...
May 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28544874/the-relative-safety-of-paternal-maternal-and-traditional-foster-care-placements
#2
Jesse J Helton, Brian B Boutwell, Michael DiBernardo
When children are placed into foster care the caseworker must give preference to an adult relative, many of whom are grandparents, over an unrelated caregiver. This kinship preference is based in evolutionary biology, which suggests that the imperative to care for a child should be greater for kin versus non-kin. However, not all kin are related to a child in the same way, and level of paternity uncertainty may influence level of care provided. For instance, maternal grandparents can be assured that they share genetic material with their grandchild, while paternal grandparents may not have the same level of certainty...
May 22, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28542796/interleukin-2-as-an-adjunct-to-antiretroviral-therapy-for-hiv-positive-adults
#3
REVIEW
Jennifer Onwumeh, Charles I Okwundu, Tamara Kredo
BACKGROUND: Human immunodeficiency virus (HIV) continues to be a leading cause of morbidity and mortality, particularly in sub-Saharan Africa. Although antiretroviral drugs have helped to improve the quality of life and life expectancy of HIV-positive individuals, there is still a need to explore other interventions that will help to further reduce the disease burden. One potential strategy is the use of interleukin-2 (IL-2) in combination with antiretroviral therapy (ART). IL-2 is a cytokine that regulates the proliferation and differentiation of lymphocytes and may help to boost the immune system...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28542194/using-g6pd-tests-to-enable-the-safe-treatment-of-plasmodium-vivax-infections-with-primaquine-on-the-thailand-myanmar-border-a-cost-effectiveness-analysis
#4
Angela Devine, Minnie Parmiter, Cindy S Chu, Germana Bancone, François Nosten, Ric N Price, Yoel Lubell, Shunmay Yeung
BACKGROUND: Primaquine is the only licensed antimalarial for the radical cure of Plasmodium vivax infections. Many countries, however, do not administer primaquine due to fear of hemolysis in those with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In other settings, primaquine is given without G6PD testing, putting patients at risk of hemolysis. New rapid diagnostic tests (RDTs) offer the opportunity to screen for G6PD deficiency prior to treatment with primaquine. Here we assessed the cost-effectiveness of using G6PD RDTs on the Thailand-Myanmar border and provide the model as an online tool for use in other settings...
May 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28538161/that-certain-something-focusing-on-similarities-reduces-judgmental-uncertainty
#5
Ann-Christin Posten, Thomas Mussweiler
Comparative thinking is an efficient cognitive strategy that reduces judgmental uncertainty. However, comparisons may be conducted with a focus on similarities or differences. Similarity-focused comparisons seem to facilitate information-transfer, which has been suggested to drive the uncertainty-reducing effect of comparisons. This implies that similarity-focused comparisons reduce uncertainty more than dissimilarity-focused comparisons. Two experiments examine this assumption. In Study 1, a similarity-focus (compared to a difference-focus and a neutral control condition) increased judgmental certainty when the comparison was based on confident standard-knowledge...
May 21, 2017: Cognition
https://www.readbyqxmd.com/read/28537982/selective-cannabinoids-for-chronic-neuropathic-pain-a-systematic-review-and-meta-analysis
#6
Howard Meng, Bradley Johnston, Marina Englesakis, Dwight E Moulin, Anuj Bhatia
BACKGROUND: There is a lack of consensus on the role of selective cannabinoids for the treatment of neuropathic pain (NP). Guidelines from national and international pain societies have provided contradictory recommendations. The primary objective of this systematic review and meta-analysis (SR-MA) was to determine the analgesic efficacy and safety of selective cannabinoids compared to conventional management or placebo for chronic NP. METHODS: We reviewed randomized controlled trials that compared selective cannabinoids (dronabinol, nabilone, nabiximols) with conventional treatments (eg, pharmacotherapy, physical therapy, or a combination of these) or placebo in patients with chronic NP because patients with NP may be on any of these therapies or none if all standard treatments have failed to provide analgesia and or if these treatments have been associated with adverse effects...
May 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28535104/measuring-the-value-of-new-drugs-validity-and-reliability-of-4-value-assessment-frameworks-in-the-oncology-setting
#7
Tanya G K Bentley, Joshua T Cohen, Elena B Elkin, Julie Huynh, Arnab Mukherjea, Thanh H Neville, Matthew Mei, Ronda Copher, Russell Knoth, Ioana Popescu, Jackie Lee, Jenelle M Zambrano, Michael S Broder
BACKGROUND: Several organizations have developed frameworks to systematically assess the value of new drugs. OBJECTIVE: To evaluate the convergent validity and interrater reliability of 4 value frameworks to understand the extent to which these tools can facilitate value-based treatment decisions in oncology. METHODS: Eight panelists used the American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), Institute for Clinical and Economic Review (ICER), and National Comprehensive Cancer Network (NCCN) frameworks to conduct value assessments of 15 drugs for advanced lung and breast cancers and castration-refractory prostate cancer...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28534040/elsberg-syndrome-a-rarely-recognized-cause-of-cauda-equina-syndrome-and-lower-thoracic-myelitis
#8
Filippo Savoldi, Timothy J Kaufmann, Eoin P Flanagan, Michel Toledano, Brian G Weinshenker
OBJECTIVE: Elsberg syndrome (ES) is an established but often unrecognized cause of acute lumbosacral radiculitis with myelitis related to recent herpes virus infection. We defined ES, determined its frequency in patients with cauda equina syndrome (CES) with myelitis, and evaluated its clinical, radiologic, and microbiologic features and outcomes. METHODS: We searched the Mayo Clinic medical records for ES and subsequently for combinations of index terms to identify patients with suspected CES and myelitis...
July 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28532354/the-road-to-certainty-and-back
#9
Gerald Westheimer
The author relates his intellectual journey from eye-testing clinician to experimental vision scientist. Starting with the quest for underpinning in physics and physiology of vague clinical propositions and of psychology's acceptance of thresholds as "fuzzy-edged," and a long career pursuing a reductionist agenda in empirical vision science, his journey led to the realization that the full understanding of human vision cannot proceed without factoring in an observer's awareness, with its attendant uncertainty and open-endedness...
October 14, 2016: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28530675/reevaluation-of-snp-heritability-in-complex-human-traits
#10
Doug Speed, Na Cai, Michael R Johnson, Sergey Nejentsev, David J Balding
SNP heritability, the proportion of phenotypic variance explained by SNPs, has been reported for many hundreds of traits. Its estimation requires strong prior assumptions about the distribution of heritability across the genome, but current assumptions have not been thoroughly tested. By analyzing imputed data for a large number of human traits, we empirically derive a model that more accurately describes how heritability varies with minor allele frequency (MAF), linkage disequilibrium (LD) and genotype certainty...
May 22, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28529188/grade-guidelines-17-assessing-the-risk-of-bias-associated-with-missing-participant-outcome-data-in-a-body-of-evidence
#11
Gordon H Guyatt, Shanil Ebrahim, Pablo Alonso-Coello, Bradley C Johnston, Alexander G Mathioudakis, Matthias Briel, Reem A Mustafa, Xin Sun, Stephen D Walter, Diane Heels-Ansdell, Ignacio Neumann, Lara A Kahale, Alfonso Iorio, Joerg Meerpohl, Holger J Schünemann, Elie A Akl
OBJECTIVE: To provide GRADE guidance for assessing risk of bias across an entire body of evidence consequent on missing data for systematic reviews of both binary and continuous outcomes. STUDY DESIGN: Systematic survey of published methodological research, iterative discussions, testing in systematic reviews, and feedback from the GRADE Working Group. RESULTS: Approaches begin with a primary meta-analysis using a complete case analysis followed by sensitivity meta-analyses imputing, in each study, data for those with missing data, and then pooling across studies...
May 18, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28529184/the-grade-working-group-clarifies-the-construct-of-certainty-of-evidence
#12
Monica Hultcrantz, David Rind, Elie A Akl, Shaun Treweek, Reem A Mustafa, Alfonso Iorio, Brian S Alper, Joerg J Meerpohl, M Hassan Murad, Mohammed T Ansari, Srinivasa Vittal Katikireddi, Pernilla Östlund, Sofia Tranæus, Robin Christensen, Gerald Gartlehner, Jan Brozek, Ariel Izcovich, Holger Schünemann, Gordon Guyatt
OBJECTIVE: To clarify the GRADE (grading of recommendations assessment, development and evaluation) definition of certainty of evidence and suggest possible approaches to rating certainty of the evidence for systematic reviews, health technology assessments and guidelines. STUDY DESIGN AND SETTING: This work was carried out by a project group within the GRADE Working Group, through brainstorming and iterative refinement of ideas, using input from workshops, presentations, and discussions at GRADE Working Group meetings to produce this document, which constitutes official GRADE guidance...
May 18, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28528816/vertical-transmission-of-microcystins-to-nile-crocodile-crocodylus-niloticus-eggs
#13
Alukhethi Singo, Jan G Myburgh, Peter N Laver, Elizabeth A Venter, Gezina C H Ferreira, Gertruida M Rösemann, Christo J Botha
Cyanobacteria or blue green algae are known for their extensive and highly visible blooms in eutrophic, stagnant freshwater bodies. Climate change and global warming have also contributed to a rise in toxic cyanobacterial blooms. One of the most important cyanobacteria is Microcystis aeruginosa, which can synthesize various microcystins that can affect the health of terrestrial and aquatic animals. Commercial Nile crocodile (Crocodylus niloticus) farming in South Africa is based on keeping breeders (adult males and females) in big dams on farms (captive-bred approach)...
May 18, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28526043/management-of-rare-diseases-of-the-head-neck-and-teeth-results-of-a-french-population-based-prospective-8-year-study
#14
Lisa Friedlander, Rémy Choquet, Eva Galliani, Myriam de Chalendar, Claude Messiaen, Amélie Ruel, Marie-Paule Vazquez, Ariane Berdal, Corinne Alberti, Muriel De La Dure Molla
BACKGROUND: In the last ten years, national rare disease networks have been established in France, including national centres of expertise and regional ones, with storage of patient data in a bioinformatics tool. The aim was to contribute to the development and evaluation of health strategies to improve the management of patients with rare diseases. The objective of this study has been to provide the first national-level data concerning rare diseases of the head, neck and teeth and to assess the balance between demand and supply of care in France...
May 19, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28525528/sevelamer-versus-calcium-based-phosphate-binders-for-chronic-kidney-disease
#15
Gonzalo A Bravo-Soto, Trinidad Madrid
Chronic kidney disease-mineral and bone disorder is prevalent. There is controversy regarding whether calcium-based phosphate binders or sevelamer - a non-calcium phosphate binder – constitute a better therapeutic alternative. Searching in Epistemonikos database, which is maintained by screening multiple information sources, we identified 12 systematic reviews comprising 61 studies of which 41 correspond to randomized trials addressing the question of this article. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach...
May 12, 2017: Medwave
https://www.readbyqxmd.com/read/28522102/retrospective-multicenter-matched-case-control-study-on-the-risk-factors-for-narcolepsy-with-special-focus-on-vaccinations-including-pandemic-influenza-vaccination-and-infections-in-germany
#16
Doris Oberle, Jutta Pavel, Geert Mayer, Peter Geisler, Brigitte Keller-Stanislawski
OBJECTIVE: Studies associate pandemic influenza vaccination with narcolepsy. In Germany, a retrospective, multicenter, matched case-control study was performed to identify risk factors for narcolepsy, particularly regarding vaccinations (seasonal and pandemic influenza vaccination) and infections (seasonal and pandemic influenza) and to quantify the detected risks. METHODS: Patients with excessive daytime sleepiness who had been referred to a sleep center between April 2009 and December 2012 for multiple sleep latency test (MSLT) were eligible...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28521647/a-qualitative-investigation-of-lay-perspectives-of-diagnosis-and-self-management-strategies-employed-by-people-with-progressive-multiple-sclerosis
#17
Julia Frost, Jane Grose, Nicky Britten
This article explores how people with progressive multiple sclerosis give meaning to their experiences. It builds upon the self-management literature, which has captured the tension between the desire for retaining normalcy and the increasing burden of self-management associated with chronic disease progression. This repeat interview study is empirically grounded in 28 interviews with 14 people with progressive multiple sclerosis. We identified gender differences in diagnosis-seeking which impacted subsequent sense-making...
May 2017: Health (London)
https://www.readbyqxmd.com/read/28521316/introduction-of-complementary-foods-to-infants
#18
Christina West
While earlier food allergy prevention strategies implemented avoidance of allergenic foods in infancy, the current paradigm is shifting from avoidance to controlled exposure. This review focuses on the outcome of recent randomized controlled trials, which have examined the early introduction of allergenic foods for allergy prevention, and discusses the implementation of results in clinical practice. In infants at high risk of allergic disease, there is now direct evidence that regular early peanut consumption will reduce the prevalence of peanut allergy, compared to avoidance...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28518221/micronutrient-supplementation-in-adults-with-hiv-infection
#19
REVIEW
Marianne E Visser, Solange Durao, David Sinclair, James H Irlam, Nandi Siegfried
BACKGROUND: Micronutrient deficiencies are common among adults living with HIV disease, particularly in low-income settings where the diet may be low in essential vitamins and minerals. Some micronutrients play critical roles in maintenance of the immune system, and routine supplementation could therefore be beneficial. This is an update of a Cochrane Review previously published in 2010. OBJECTIVES: To assess whether micronutrient supplements are effective and safe in reducing mortality and HIV-related morbidity of HIV-positive adults (excluding pregnant women)...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28516513/evaluating-an-educational-intervention-to-alleviate-distress-amongst-men-with-newly-diagnosed-prostate-cancer-and-their-partners
#20
Lindsay Hedden, Richard Wassersug, Sarah Mahovlich, Phil Pollock, Monita Sundar, Robert H Bell, Larry Goldenberg, Celestia S Higano
OBJECTIVE: To determine whether an education session alleviates distress for both patients with prostate cancer and their partners; and whether their partner's attendance at the session; and disease, treatment, and sociodemographic characteristics affect changes in distress levels. PATIENTS, SUBJECTS AND METHODS: We identified men with untreated prostate cancer at the Vancouver Prostate Centre between February 2015 and March 2016 who agreed to attend our education session...
May 17, 2017: BJU International
keyword
keyword
75934
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"