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https://www.readbyqxmd.com/read/28440193/neurocognitive-correlates-in-driving-under-the-influence-of-cannabis
#1
Francesco Paolo Busardò, Manuela Pellegrini, Julia Klein, Natale Mario di Luca
Delta (9)-tetrahydrocannabinol is the main psychoactive compound in cannabis and is commonly identified in blood samples from arrested drivers assumed to drive under the influence of drugs. Changing social norms towards cannabis and higher acceptability towards the drug emphasize the need for comprehensive understanding of the severe neurocognitive and psychomotor effects caused by cannabis and how these effects are correlated to driving skills and performance. In this review, PubMed, Cochrane Central, Scopus, Web of Science, Science Direct and EMBASE databases were used to identify and select publications up to January 2017 dealing with acute and chronic neurocognitive effects induced by cannabis and ability to drive...
April 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28439544/quantifying-the-negative-impact-of-brain-drain-on-the-integration-of-european-science
#2
Omar A Doria Arrieta, Fabio Pammolli, Alexander M Petersen
The 2004/2007 European Union (EU) enlargement by 12 member states offers a unique opportunity to quantify the impact of EU efforts to expand and integrate the scientific competitiveness of the European Research Area (ERA). We apply two causal estimation schemes to cross-border collaboration data extracted from millions of academic publications from 1996 to 2012, which are disaggregated across 14 subject areas and 32 European countries. Our results illustrate the unintended consequences following the 2004/2007 enlargement, namely, its negative impact on cross-border collaboration in science...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28435116/chiari-malformation-type-1-a-systematic-review-of-natural-history-and-conservative-management
#3
REVIEW
Benjamin Langridge, Edward Phillips, David Choi
OBJECTIVE: Chiari type 1 malformations (CM-1) are variations of hind-brain development which can sometimes occur in asymptomatic individuals. Conventional treatment is surgical decompression, but little is known about the natural history of patients who do not undergo surgical management. Appreciation of this information is critical to determine how these patients should be managed. We conducted a systematic review of the literature to determine the natural history of CM-1 particularly in patients who did not undergo surgery, and in asymptomatic individuals, to help inform patients and doctors when surgery is likely to be beneficial...
April 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28431843/on-the-complex-interaction-between-mathematics-and-the-sciences-of-living-systems-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding-affective-evaluative
#4
https://www.readbyqxmd.com/read/28430672/lamotrigine-uses-in-psychiatric-practice-beyond-bipolar-prophylaxis-a-hope-or-hype
#5
Ahmed Naguy, Najah Al-Enezi
BACKGROUND: Lamotrigine (LAM), an antiepileptic, with panoply of indications and uses in neurology, is FDA approved, in psychiatry, for bipolar prophylaxis. Apart from this indication, trend of its use in psychiatry is on the rise addressing a multitude of disorders. STUDY QUESTION: LAM remains one of only few psychotropic drugs with antiglutamate activity. This might render LAM a potential therapeutic option in treatment-resistant major psychiatric disorders. We reviewed LAM pharmacology and its diverse indications while examining the extant evidence...
April 19, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28430363/cerebrolysin-for-acute-ischaemic-stroke
#6
REVIEW
Liliya Eugenevna Ziganshina, Tatyana Abakumova, Ludivine Vernay
BACKGROUND: Cerebrolysin is a mixture of low-molecular-weight peptides and amino acids derived from pigs' brain tissue, which has potential neuroprotective and neurotrophic properties. It is widely used in the treatment of acute ischaemic stroke in Russia, Eastern Europe, China, and other Asian and post-Soviet countries. OBJECTIVES: To assess the benefits and risks of cerebrolysin for treating acute ischaemic stroke. SEARCH METHODS: In May 2016 we searched the Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, Embase, Web of Science Core Collection, with Science Citation Index, LILACS, OpenGrey, and a number of Russian Databases...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28429473/surgery-for-limited-stage-small-cell-lung-cancer
#7
REVIEW
Hayley Barnes, Katharine See, Stephen Barnett, Renée Manser
BACKGROUND: Current treatment guidelines for limited-stage small-cell lung cancer (SCLC) recommend concomitant platinum-based chemo-radiotherapy plus prophylactic cranial irradiation, based on the premise that SCLC disseminates early, and is chemosensitive. However, although there is usually a favourable initial response, relapse is common and the cure rate for limited-stage SCLC remains relatively poor. Some recent clinical practice guidelines have recommended surgery for stage 1 (limited) SCLC followed by adjuvant chemotherapy, but this recommendation is largely based on the findings of observational studies...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28429459/nitric-oxide-donors-nitrates-l-arginine-or-nitric-oxide-synthase-inhibitors-for-acute-stroke
#8
REVIEW
Philip Mw Bath, Kailash Krishnan, Jason P Appleton
BACKGROUND: Nitric oxide (NO) has multiple effects that may be beneficial in acute stroke, including lowering blood pressure, and promoting reperfusion and cytoprotection. Some forms of nitric oxide synthase inhibition (NOS-I) may also be beneficial. However, high concentrations of NO are likely to be toxic to brain tissue. This is an update of a Cochrane review first published in 1998, and last updated in 2002. OBJECTIVES: To assess the safety and efficacy of NO donors, L-arginine, and NOS-I in people with acute stroke...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28426957/emerging-global-initiatives-in-neurogenetics-the-enhancing-neuroimaging-genetics-through-meta-analysis-enigma-consortium
#9
Carrie E Bearden, Paul M Thompson
The Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) Consortium is a global team science effort, now including over 800 scientists spread across 340 institutions in 35 countries, with the shared goal of understanding disease and genetic influences on the brain. This "crowdsourcing" approach to team neuroscience has unprecedented power for advancing our understanding of both typical and atypical human brain development.
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28426908/clinically-useful-brain-imaging-for-neuropsychiatry-how-can-we-get-there
#10
REVIEW
Michael P Milham, R Cameron Craddock, Arno Klein
Despite decades of research, visions of transforming neuropsychiatry through the development of brain imaging-based "growth charts" or "lab tests" have remained out of reach. In recent years, there is renewed enthusiasm about the prospect of achieving clinically useful tools capable of aiding the diagnosis and management of neuropsychiatric disorders. The present work explores the basis for this enthusiasm. We assert that there is no single advance that currently has the potential to drive the field of clinical brain imaging forward...
April 20, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28426839/medical-history-in-the-hellenic-journal-of-nuclear-medicine
#11
EDITORIAL
Andreas Otte, Byeong Cheol Ahn
The Hellenic Journal of Nuclear Medicine is about to celebrate its 20th anniversary end of 2017. On board of the editorial team since 2003, this journal has influenced me like a good friend over the many past years. From time to time, the journal has published interesting and valuable historical notes. They show that nuclear medicine has a history and that medicine is its basis. They also teach us today, and some of the ancient perspectives and approaches are still valid. The reader of HJNM may be interested in these historical contributions, as they are timeless...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28414713/less-fear-more-diversity
#12
Gregory J Quirk
Fear is an instinctual response that's adaptive and critical for survival when it is short-lived but can lead to anxiety disorders when chronic. Studying how the brain controls our fears helps us understand the mechanisms required to recover from traumatic experiences and what goes wrong when we don't. Research in rodents has identified neural circuits and molecular mechanisms regulating fear expression. Rodent work has been amenable to translation to humans and has led to improvements in clinical therapies for anxiety disorders...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28409914/the-chemistry-of-thought-the-role-of-the-measurement-sciences-in-brain-research
#13
Anne Milasincic Andrews, Rohit Bhargava, Robert Kennedy, Lingjun Li, Jonathan V Sweedler
No abstract text is available yet for this article.
April 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28408740/multi-component-quantitative-magnetic-resonance-imaging-by-phasor-representation
#14
Frank J Vergeldt, Alena Prusova, Farzad Fereidouni, Herbert van Amerongen, Henk Van As, Tom W J Scheenen, Arjen N Bader
Quantitative magnetic resonance imaging (qMRI) is a versatile, non-destructive and non-invasive tool in life, material, and medical sciences. When multiple components contribute to the signal in a single pixel, however, it is difficult to quantify their individual contributions and characteristic parameters. Here we introduce the concept of phasor representation to qMRI to disentangle the signals from multiple components in imaging data. Plotting the phasors allowed for decomposition, unmixing, segmentation and quantification of our in vivo data from a plant stem, a human and mouse brain and a human prostate...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28405215/the-american-psychosomatic-society-integrating-mind-brain-body-and-social-context-in-medicine-since-1942
#15
REVIEW
Christoph Herrmann-Lingen
BACKGROUND: The American Psychosomatic Society is one of the oldest and probably the most influential scientific society in psychosomatic/biopsychosocial research worldwide. The current article delineates the historical development and current strategic orientation of the society. METHOD: Review of published literature, archived materials and current documents of the society. RESULTS: The American Psychosomatic Society (APS) was founded in 1942, originally named the "American Society for Research in Psychosomatic Problems "...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28404830/implications-of-plan-based-generalization-in-sensorimotor-adaptation
#16
Samuel David McDougle, Krista M Bond, Jordan A Taylor
Generalization is a fundamental aspect of behavior, allowing for the transfer of knowledge from one context to another. The details of this transfer are thought to reveal how the brain represents what it learns. Generalization has been a central focus in studies of sensorimotor adaptation, and its pattern has been well-characterized: learning of new dynamic and kinematic transformations in one region of space tapers off in a Gaussian-like fashion to neighboring untrained regions, echoing tuned population codes in the brain...
April 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28397140/separating-the-effect-of-reward-from-corrective-feedback-during-learning-in-patients-with-parkinson-s-disease
#17
Michael Freedberg, Jonathan Schacherer, Kuan-Hua Chen, Ergun Y Uc, Nandakumar S Narayanan, Eliot Hazeltine
Parkinson's disease (PD) is associated with procedural learning deficits. Nonetheless, studies have demonstrated that reward-related learning is comparable between patients with PD and controls (Bódi et al., Brain, 132(9), 2385-2395, 2009; Frank, Seeberger, & O'Reilly, Science, 306(5703), 1940-1943, 2004; Palminteri et al., Proceedings of the National Academy of Sciences of the United States of America, 106(45), 19179-19184, 2009). However, because these studies do not separate the effect of reward from the effect of practice, it is difficult to determine whether the effect of reward on learning is distinct from the effect of corrective feedback on learning...
April 10, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28397076/neural-evidence-for-predictive-coding-in-auditory-cortex-during-speech-production
#18
Kayoko Okada, William Matchin, Gregory Hickok
Recent models of speech production suggest that motor commands generate forward predictions of the auditory consequences of those commands, that these forward predications can be used to monitor and correct speech output, and that this system is hierarchically organized (Hickok, Houde, & Rong, Neuron, 69(3), 407--422, 2011; Pickering & Garrod, Behavior and Brain Sciences, 36(4), 329--347, 2013). Recent psycholinguistic research has shown that internally generated speech (i.e., imagined speech) produces different types of errors than does overt speech (Oppenheim & Dell, Cognition, 106(1), 528--537, 2008; Oppenheim & Dell, Memory & Cognition, 38(8), 1147-1160, 2010)...
April 10, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28396096/what-does-semantic-tiling-of-the-cortex-tell-us-about-semantics
#19
Lawrence W Barsalou
Recent use of voxel-wise modeling in cognitive neuroscience suggests that semantic maps tile the cortex. Although this impressive research establishes distributed cortical areas active during the conceptual processing that underlies semantics, it tells us little about the nature of this processing. While mapping concepts between Marr's computational and implementation levels to support neural encoding and decoding, this approach ignores Marr's algorithmic level, central for understanding the mechanisms that implement cognition, in general, and conceptual processing, in particular...
April 7, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28394031/degeneration-of-rapid-eye-movement-sleep-circuitry-underlies-rapid-eye-movement-sleep-behavior-disorder
#20
REVIEW
Dillon McKenna, John Peever
During healthy rapid eye movement sleep, skeletal muscles are actively forced into a state of motor paralysis. However, in rapid eye movement sleep behavior disorder-a relatively common neurological disorder-this natural process is lost. A lack of motor paralysis (atonia) in rapid eye movement sleep behavior disorder allows individuals to actively move, which at times can be excessive and violent. At first glance this may sound harmless, but it is not because rapid eye movement sleep behavior disorder patients frequently injure themselves or the person they sleep with...
April 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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