Yoshifumi Takahashi, Hiroyuki Fujiwara, Kouji Yamamoto, Masashi Takano, Morikazu Miyamoto, Kosei Hasegawa, Maiko Miwa, Toyomi Satoh, Hiroya Itagaki, Takashi Hirakawa, Mayuyo Mori-Uchino, Tomonori Nagai, Yoshinobu Hamada, Soichi Yamashita, Hiroko Yano, Tomoyasu Kato, Keiichi Fujiwara, Mitsuaki Suzuki
OBJECTIVE: In Japan, perioperative prophylaxis of pulmonary embolism (PE) in gynecologic cancer patients with preoperative asymptomatic venous thromboembolism (VTE) has not been well established yet. The GOTIC-VTE trial was a prospective, multi-center, single-arm clinical trial to investigate the prevention of postoperative symptomatic PE onset by seamless anticoagulant therapy from the preoperative period to 4 weeks after surgery instead of using intermittent pneumatic compression. METHODS: Anticoagulant therapy was started immediately after asymptomatic VTE diagnosis and stopped preoperatively according to the rules of each institution...
January 1, 2024: Journal of Gynecologic Oncology