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https://www.readbyqxmd.com/read/29932030/energy-metabolism-impairment-in-migraine
#1
Sabina Cevoli, Valentina Favoni, Pietro Cortelli
Migraine is a common disabling neurological disorder which is characterised by recurring headache associated with a variety of sensory and autonomic symptoms. The pathophysiology of migraine remains not entirely understood, although many mechanisms involving the central and peripheral nervous system are now becoming clear. In particular, it is widely accepted that migraine is associated with energy metabolic impairment of the brain. The purpose of this review is to present an update overview of the energy metabolism involvement in the migraine pathophysiology...
June 22, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29929022/risk-factors-for-surgical-site-infection-following-operative-treatment-of-ankle-fractures-a-systematic-review-and-meta-analysis
#2
REVIEW
Jiashen Shao, Huixin Zhang, Bing Yin, Jia Li, Yanbin Zhu, Yingze Zhang
BACKGROUND: This study aims to quantitatively summarize risk factors associated with surgical site infection after open reduction and internal fixation of ankle fractures. METHODS: Relevant original studies were searched in Medline, Embase, China National Knowledge Infrastructure, Wanfang database and Cochrane central database (all through April 2018). Studies eligible had to meet the quality assessment criteria by Newcastle-Ottawa Scale and to evaluate the risk factors for surgical site infection after open reduction and internal fixation of ankle fractures...
June 18, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29928908/advancement-in-the-treatment-of-haemophilia
#3
REVIEW
Rahul Bhardwaj, Goutam Rath, Amit K Goyal
Poor understanding of the pathophysiological mechanisms involved in Haemophilia is a major obstacle in accessing effective haemophilia disease management. Haemophilia is a life-frightening bleeding problem in which there are repeated bleeding episodes. Various approaches have been used, involves clotting factor replacement therapy for effective bleeding control in Haemophilia. Current advancements in the management of patients with haemophilia include altered pharmacokinetics clotting factor concentrates for better prophylaxis and management of haemophilia...
June 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29923176/augmented-nrf2-activation-protects-adult-sickle-mice-from-lethal-acute-chest-syndrome
#4
Samit Ghosh, Rimi Hazra, Chibueze A Ihunnah, Frances Weidert, Bethany Flage, Solomon F Ofori-Acquah
Acute chest syndrome (ACS) mortality in sickle cell disease (SCD) rises sharply in young adult patients and mechanism-based prophylaxis is lacking. In SCD, haem oxygenase-1 (HO-1) declines with age and ACS is associated with low HO-1. To test if enhanced HO-1 can reduce ACS mortality, young SCD mice were treated with D3T (3H-1,2-dithiole-3-thione), an activator of nuclear-factor erythroid 2 like 2, which controls HO-1 expression, for 3 months. Following haem-induced ACS, all vehicle-treated mice succumbed to severe lung injury, while D3T-treated mice had significantly improved survival...
June 19, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29912812/multicenter-review-of-current-practices-associated-with-venous-thromboembolism-prophylaxis-in-pediatric-patients-after-trauma
#5
Amee M Bigelow, Katherine T Flynn-O'Brien, Pippa M Simpson, Mahua Dasgupta, Sheila J Hanson
OBJECTIVES: Frequency of venous thromboembolism in pediatric trauma patients admitted to PICUs is not insignificant, ranging up to 6%. Risk factors have been identified in this population. However, there is little consensus of actual venous thromboembolism prophylaxis practice. We examined factors associated with venous thromboembolism prophylaxis in PICUs. DESIGN: A retrospective study evaluating associations with mechanical venous thromboembolism prophylaxis, pharmacologic venous thromboembolism prophylaxis, or dual therapy (DUAL) prophylaxis compared with no venous thromboembolism prophylaxis...
June 15, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29909659/-the-association-between-maternal-periodontal-health-and-adverse-pregnancy-outcomes
#6
István Gera
Data from epidemiological and clinical studies published in the past two decades indicate certain association between periodontal disease and increased risk for preterm birth or low birth weight. Although the strength of those observed associations is weak, periodontitis today is considered as one of the potentially modifiable risk factors for adverse pregnancy outcomes. The aims of the publication are to summarize the epidemiological and clinical evidence for the impact of periodontal disease on adverse pregnancy outcomes and to make an attempt to overview the potential biological mechanism behind this association...
June 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29903008/immunomodulatory-properties-of-quercetin-3-o-%C3%AE-l-rhamnopyranoside-from-rapanea-melanophloeos-against-influenza-a-virus
#7
Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O Aro, Jacobus N Eloff, Lyndy J McGaw, Folorunso O Fasina
BACKGROUND: Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases of this disease is widely recognized. Drug resistance and side effects of chemical treatments have been observed, resulting in increased interest in alternative use of herbal medications for prophylaxis against this infection. The South African medicinal plant, Rapanea melanophloeos (RM) (L.) Mez of the family Myrsinaceae was selected owing to its traditional use for the treatment of several diseases such as respiratory ailments and also previous preliminary studies of anti-influenza activity of its methanolic extract...
June 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29896667/glycoproteins-of-hhv-6a-and-hhv-6b
#8
Huamin Tang, Yasuko Mori
Recently, human herpesvirus 6A and 6B (HHV-6A and HHV-6B) were classified into distinct species. Although these two viruses share many similarities, cell tropism is one of their striking differences, which is partially because of the difference in their entry machinery. Many glycoproteins of HHV-6A/B have been identified and analyzed in detail, especially in their functions during entry process into host cells. Some of these glycoproteins were unique to HHV-6A/B. The cellular factors associated with these viral glycoproteins (or glycoprotein complex) were also identified in recent years...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29896017/impact-of-anesthesia-modality-and-mechanical-venous-thromboembolism-prophylaxis-on-the-incidence-of-symptomatic-deep-venous-thrombosis-after-tka
#9
Yoshinori Ishii, Hideo Noguchi, Junko Sato, Satoshi Takayama, Yui Okada, Shin-Ichi Toyabe
Background: Venous thromboembolic events (VTE) are a common complication of total knee arthroplasty (TKA). Prior studies have discussed the utility of mechanical VTE prophylaxis as a monotherapy for low-risk TKA patients. We assess the incidence of clinically significant deep venous thrombosis (DVT) or pulmonary embolism (PE) in low-risk TKA patients who receive mechanical VTE prophylaxis and undergo spinal, epidural, or general anesthesia for their surgery. Methods: A retrospective study was performed on consecutive low-risk patients who received a TKA between July 2002 and June 2015 with spinal anesthesia ( n  = 65), epidural and general anesthesia ( n  = 154), or general anesthesia alone ( n  = 152)...
April 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29895159/in-search-of-effective-h1n1-neuraminidase-inhibitor-by-molecular-docking-antiviral-evaluation-and-membrane-interaction-studies-using-nmr
#10
K Malbari, H Gonsalves, A Chintakrindi, D Gohil, M Joshi, S Kothari, S Srivastava, A Chowdhary, M Kanyalkar
Considering the need for discovery of new antiviral drugs, in view to combat the issue of resistance particularly to anti-influenza drugs, a series of 2'-amino, 3'-amino and 2', 4'-dihydroxy chalcone derivatives were designed. Structure-based drug design was used to design inhibitors of influenza virus - H1N1 neuraminidase enzyme. These were further optimized by a combination of iterative medicinal chemistry principles and molecular docking. Based on the best docking scores, some chalcone derivatives were synthesized and characterized by infrared spectroscopy (IR) and proton nuclear magnetic resonance (NMR)...
2018: Acta Virologica
https://www.readbyqxmd.com/read/29892322/thromboprophylaxis-in-head-and-neck-microvascular-reconstruction
#11
REVIEW
Manoj Abraham, Arvind Badhey, Shirley Hu, Sameep Kadakia, J K Rasamny, Augustine Moscatello, Yadranko Ducic
Head and neck patients undergoing microvascular reconstruction are at high risk for thromboembolism. While the prevention of thromboembolism has become an essential aspect of care, within the field of microsurgery, concern for anastomotic complications have hindered the creation of an accepted regimen. The aim of this review was to evaluate the risks and benefits of prophylactic agents for thromboprophylaxis. A literature search was conducted in MEDLINE, Cochrane Library, and PubMed/NCBI databases. Articles discussing thromboprophylaxis in otolaryngology, head and neck surgery, or microvascular reconstruction were considered in the review from the past 30 years...
June 2018: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29891258/epidemiology-of-lower-extremity-deep-venous-thrombosis-in-critically-ill-adolescents
#12
Edward Vincent S Faustino, Veronika Shabanova, Matthew G Pinto, Simon Li, Erin Trakas, Michael Miksa, Shira Gertz, Lee A Polikoff, Massimo Napolitano, Adele R Brudnicki, Joana A Tala, Cicero T Silva
OBJECTIVE: To determine the epidemiology of lower extremity deep venous thrombosis (DVT) in critically ill adolescents, which currently is unclear. STUDY DESIGN: We performed a multicenter, prospective, cohort study. Adolescents aged 13-17 years who were admitted to 6 pediatric intensive care units and were anticipated to receive cardiopulmonary support for at least 48 hours were eligible, unless they were admitted with DVT or pulmonary embolism or were receiving or anticipated to receive therapeutic anticoagulation...
June 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29880270/enriched-brain-omega-3-polyunsaturated-fatty-acids-confer-neuroprotection-against-microinfarction
#13
Chuanming Luo, Huixia Ren, Xiaoli Yao, Zhe Shi, Fengyin Liang, Jing X Kang, Jian-Bo Wan, Zhong Pei, Kuan-Pin Su, Huanxing Su
Cerebral microinfarcts have significant effects on the development of geriatric neurological disorders, including vascular dementia and Alzheimer's disease. However, little is known about the pathophysiological mechanisms involved in the evolution of microinfarcts and potential treatment and prevention against these microvascular ischemic lesions. In the present study, the "single cortical microinfarct model" generated via occluding a penetrating arteriole by femtosecond laser ablation and the "multiple diffuse microinfarcts model" induced by unilateral injection of cholesterol crystals through the internal carotid artery were established to investigate the pathophysiological mechanisms underlying the evolution of microinfarcts and the effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on alleviating microinfarct burdens and functional deficits...
June 4, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29878372/clinical-effect-of-enoxaparin-on-international-normalized-ratio-following-hepato-pancreatico-biliary-and-gastroesophageal-resection
#14
Matthew W Kelecy, Travis Shutt, Jack Rostas, Robert C G Martin
BACKGROUND AND OBJECTIVES: Enoxaparin inactivates factor Xa via a complex formed after binding to circulating anti-thrombin III. This mechanism is reported not to alter hemostatic measures such as clotting time, PT, or PTT. To date, no clinical trials have shown a causal relationship between the clinical/pharmacological effects of enoxaparin on international normalized ratio (INR). The aim of our study is to show the clinical effect of enoxaparin on INR. METHODS: Patients (N = 350) were reviewed from our prospective IRB approved databases undergoing gastroesophageal or hepatobiliary surgeries...
June 7, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29876127/incidence-of-deep-venous-thrombosis-following-periacetabular-and-derotational-femoral-osteotomy-a-case-for-mechanical-prophylaxis
#15
Matthew J Kraeutler, Sivashanmugam Raju, Tigran Garabekyan, Omer Mei-Dan
There are currently no established guidelines for appropriate antithrombotic prophylaxis following periacetabular osteotomy (PAO) or derotational femoral osteotomy (DFO). The purpose of this study was to determine the incidence of clinical deep venous thrombosis (DVT) following PAO and/or DFO wherein a portable, mechanical device and low-dose aspirin were used postoperatively for DVT prophylaxis. Patients who had undergone staged hip arthroscopy and primary PAO and/or DFO were prospectively reviewed. Following PAO/DFO, patients were prophylactically treated for thromboembolic disease with a portable, mechanical compression device for 3 weeks and low-dose aspirin for 4 weeks...
July 2018: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29874106/eubiotics-for-food-security-at-farm-level-yeast-cell-wall-products-and-their-antimicrobial-potential-against-pathogenic-bacteria
#16
Elisa Santovito, Donato Greco, Antonio F Logrieco, Giuseppina Avantaggiato
The population increase in the last century was the first cause of the industrialization of animal productions, together with the necessity to satisfy the high food demand and the lack of space and land for the husbandry practices. As a consequence, the farmers moved from extensive to intensive agricultural systems and introduced new practices, such as the administration of antimicrobial drugs. Antibiotics were then used as growth promoters and for disease prevention. The uncontrolled and continuous use of antibiotics contributed to the spread of antibiotic resistance in animals, and this had adverse impacts on human health...
June 6, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29873151/head-trauma-in-the-haemophilic-child-and-management-in-a-paediatric-emergency-department-descriptive-study
#17
P García Sánchez, M Á Molina Gutiérrez, J Martín Sánchez, L Inisterra Viu, S García García, M I Rivas Pollmar, M Martín Salces, M T Álvarez Román, V Jiménez Yuste
INTRODUCTION: Haemophilia is one of the most common inherited bleeding disorders in the Emergency Department (ED). The most dangerous site of bleeding is the central nervous system. AIMS: To describe the characteristics of haemophiliacs arrived to our ED following a head trauma and to analyse the incidence of intracranial haemorrhage (ICH). MATERIALS AND METHODS: Retrospective, analytical, observational study, conducted in a Paediatric ED...
June 6, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29871684/junctional-ectopic-tachycardia-following-tetralogy-of-fallot-repair-in-children-under-2-years
#18
Mohamed Fouad Ismail, Amr A Arafat, Tamer E Hamouda, Amira Esmat El Tantawy, Azzahra Edrees, Abdulbadee Bogis, Nashwa Badawy, Alaa B Mahmoud, Ahmed Farid Elmahrouk, Ahmed A Jamjoom
BACKGROUND: Junctional ectopic tachycardia is a serious arrhythmia that frequently occurs after tetralogy of Fallot repair. Arrhythmia prophylaxis is not feasible for all pediatric cardiac surgery patients and identification of high risk patients is required. The objectives of this study were to characterize patients with JET, identify its predictors and subsequent complications and the effect of various treatment strategies on the outcomes in selected TOF patients undergoing total repair before 2 years of age...
June 5, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29870417/venous-thromboembolism-prophylaxis-in-spine-surgery
#19
Christopher K Kepler, James McKenzie, Tyler Kreitz, Alexander Vaccaro
Venous thromboembolism (VTE) is a source of morbidity and mortality in patients undergoing orthopaedic surgery. A substantial body of literature supports the use of VTE prophylactic agents in patients undergoing lower extremity surgery. Treatment options include early mobilization, mechanical prophylaxis via pneumatic compression devices, pharmacologic agents, and venous filters. No consensus has been established regarding utilization or timing of VTE prophylaxis measures after spine surgery. The risk of VTE in patients undergoing spine surgery is not well characterized and varies substantially by the procedure and degree of neurologic compromise...
June 4, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29864630/guidelines-risk-assessment-recommendations-for-venous-thromboembolism-prophylaxis-a-comparison-and-implementability-appraisal
#20
M J Moesker, N L Damen, E E Volmeijer, D Dreesens, E M de Loos, R Vink, M Coppens, M J Kruip, K Meijer, M Langelaan, M C de Bruijne, C Wagner
INTRODUCTION: Venous thromboembolism (VTE) prophylaxis guidelines for non-surgical patients recommend VTE- and bleeding risk assessment to guide prophylactic strategies. These recommendations differ between guidelines and implementation is suboptimal. Assessing a guideline's implementability characteristics helps predicting the ease of implementation and reveals barriers. OBJECTIVES: We aimed to compare guidelines' risk assessment recommendations and critically appraise the implementability characteristics...
May 26, 2018: Thrombosis Research
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