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community-acquired pneumonia AND virus

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https://www.readbyqxmd.com/read/29237789/community-acquired-pneumonia-in-children-the-challenges-of-microbiological-diagnosis
#1
C M C Rodrigues, H Groves
Community-acquired pneumonia (CAP) is the leading cause of mortality in children under five years of age, globally. To improve the management of CAP, we must distinguish CAP from other common paediatric conditions and develop better diagnostic methods to detect the causative organism, so to best direct appropriate resources in both industrialised and developing countries. Here, we review the diagnostic modalities available for identifying viruses and bacteria in the upper and lower respiratory tract of children, with a discussion of their utility and limitations in diagnosing CAP in children...
December 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29228381/the-etiology-and-impact-of-co-infections-in-children-hospitalized-with-community-acquired-pneumonia
#2
Vikki G Nolan, Sandra R Arnold, Anna M Bramley, Krow Ampofo, Derek J Williams, Carlos G Grijalva, Wesley H Self, Evan J Anderson, Richard G Wunderink, Kathryn M Edwards, Andrew T Pavia, Seema Jain, Jonathan A McCullers
Background: Recognition that co-infections are common in children with community-acquired pneumonia (CAP) is increasing, but gaps remain in our understanding of their frequency and importance. Methods: We analyzed data from 2219 children hospitalized with CAP and compared demographics, clinical characteristics, and outcomes between groups with viruses alone, bacteria alone, or co-infections. We also assessed the frequency of selected pairings of co-detected pathogens and their clinical characteristics...
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29209590/risk-factors-for-community-acquired-pneumonia-among-adults-in-kenya-a-case-control-study
#3
Esther Muthumbi, Brett S Lowe, Cyprian Muyodi, Esther Getambu, Fergus Gleeson, J Anthony G Scott
Background: Pneumonia is a leading cause of morbidity and mortality among adults worldwide; however, the risk factors for community-acquired pneumonia in Africa are not well characterized. Methods: The authors recruited 281 cases of community-acquired pneumonia and 1202 hospital controls among patients aged ≥15 years who attended Kilifi District Hospital/Coast Provincial General Hospital in Kenya between 1994 and 6. Cases were admissions with an acute illness with ≥2 respiratory signs and evidence of consolidation on a chest radiograph...
2017: Pneumonia
https://www.readbyqxmd.com/read/29208015/molecular-etiological-profile-of-atypical-bacterial-pathogens-viruses-and-coinfections-among-infants-and-children-with-community-acquired-pneumonia-admitted-to-a-national-hospital-in-lima-peru
#4
Juana Del Valle-Mendoza, Wilmer Silva-Caso, Angela Cornejo-Tapia, Fiorella Orellana-Peralta, Eduardo Verne, Claudia Ugarte, Miguel Angel Aguilar-Luis, María Del Carmen De Lama-Odría, Ronald Nazario-Fuertes, Mónica Esquivel-Vizcarra, Verónica Casabona-Ore, Pablo Weilg, Luis J Del Valle
OBJECTIVE: The main objective of this study was to detect the presence of 14 respiratory viruses and atypical bacteria (Mycoplasma pneumoniae, Chlamydia pneumoniae), via polymerase chain reaction in patients under 18 years old hospitalized due to community-acquired pneumonia (CAP) from Lima, Peru. RESULTS: Atypical pathogens were detected in 40% (58/146); viral etiologies in 36% (52/146) and coinfections in 19% (27/146). The most common etiological agent was M...
December 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29166922/herpes-simplex-type-1-pneumonitis-and-acute-respiratory-distress-syndrome-in-a-patient-with-chronic-lymphatic-leukemia-a-case-report
#5
Miriam Luginbuehl, Alexander Imhof, Alexander Klarer
BACKGROUND: Pulmonary pathogenicity of herpes simplex virus type 1 in patients in intensive care without classic immunosuppression as well as the necessity of antiviral treatment in the case of herpes simplex virus detection in respiratory specimens in these patients is controversial. We present a case of acute respiratory distress syndrome in a patient with stable chronic lymphatic leukemia not requiring treatment, in whom we diagnosed herpes simplex virus type 1 bronchopneumonitis based on herpes simplex virus type 1 detection in bronchoalveolar lavage fluid and clinical response to antiviral treatment...
November 23, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29158922/hypoxemic-respiratory-failure-from-acute-respiratory-distress-syndrome-secondary-to-leptospirosis
#6
Shannon M Fernando, Pierre Cardinal, Peter G Brindley
Acute respiratory distress syndrome (ARDS), characterized by hypoxemic respiratory failure, is associated with a mortality of 30-50% and is precipitated by both direct and indirect pulmonary insults. Treatment is largely supportive, consisting of lung protective ventilation and thereby necessitating Intensive Care Unit (ICU) admission. The most common precipitant is community-acquired bacterial pneumonia, but other putative pathogens include viruses and fungi. On rare occasions, ARDS can be secondary to tropical disease...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29158121/systemic-cytokines-and-chemokines-on-admission-of-children-hospitalized-with-community-acquired-pneumonia
#7
Ângela G Vasconcellos, Jorge Clarêncio, Daniela Andrade, Maria-Regina A Cardoso, Aldina Barral, Cristiana M Nascimento-Carvalho
Community-acquired pneumonia (CAP) is the main cause of death in children under-5 years worldwide and Streptococcus pneumoniae is the most common bacterial agent. However, it is difficult to identify pneumococcal infection among children with CAP. We aimed to assess association between any cytokine/chemokine and pneumococcal infection in childhood CAP. Furthermore, we evaluated the diagnostic value of cytokine/chemokine for pneumococcal infection. This prospective study was conducted at an Emergency Room, in Salvador, Brazil...
November 17, 2017: Cytokine
https://www.readbyqxmd.com/read/29096010/macrolides-in-children-with-community-acquired-pneumonia-panacea-or-placebo
#8
Christopher C Blyth, Jeffrey S Gerber
Pneumonia, most often caused by a respiratory virus, is common in childhood. Mycoplasma pneumoniae also is detected frequently, particularly in older children in the era of pneumococcal conjugate vaccination. Despite recommendations for β-lactam antibiotics, macrolide antibiotics, including erythromycin, clarithromycin, and azithromycin, are prescribed frequently to children with acute lower respiratory infection. However, the significance of detecting "atypical" pathogens, including M pneumoniae, in children remains contentious...
October 31, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29094629/infectious-diseases-and-immunological-markers-associated-with-patients-with-non-hodgkin-lymphoma-treated-with-rituximab
#9
Kleber Jordão de Souza, Rodrigo Sala Ferro, Luiz Euribel Prestes-Carneiro, Paula Andreia Martins Carrilho, Dewton de Moraes Vasconcelos
BACKGROUND: The use of rituximab (RTX) is increasing, even in developing countries. It has become the first-line therapy or adjuvant to chemotherapy (CHOP; cyclophosphamide, hydroxydaunorubicin, oncovin and prednisone) for various diseases, including B cell lymphoma and autoimmune diseases. AIM: We describe the infectious diseases and immunological markers associated with RTX treatment of patients with non-Hodgkin lymphoma (NHL). METHODS: Serum immunoglobulins were determined before and after intravenous immunoglobulin (IVIg) administration...
November 2, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29071842/-literature-study-on-prevention-and-treatment-of-community-acquired-pneumonia-by-traditional-chinese-medicine
#10
De-Min Li, Shi-Huan Tang, Qiang Liao, Wei Chen, Hong-Chun Zhang
Among the literatures of the prevention and treatment of community-acquired pneumonia (CAP) published in recent years, there were 16 kinds of classic prescription, including 52 RCTs about Maxingshigan Decoction, 21Chinese patent medicines. There are eight kinds of indications for the drug specification, among which the literatures of Tan Reqing injection accounted for the most about 136 RCTs; There were literatures about non-drug treatment, including: acupuncture, Chinese medicine paste, enema, Chinese medicine ionization, Chinese medicine fumigation, bamboo cans and so on...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29050992/the-impact-of-13-valent-pneumococcal-conjugate-vaccination-on-virus-associated-community-acquired-pneumonia-in-elderly-exploratory-analysis-of-the-capita-trial
#11
S M Huijts, F E J Coenjaerts, M Bolkenbaas, C H van Werkhoven, D E Grobbee, M J M Bonten
OBJECTIVES: Our objective was to evaluate whether vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) prevents the incidence of community-acquired pneumonia (CAP) caused by influenza (influenza-associated CAP, IA-CAP) or other respiratory viruses in the elderly. METHODS: This analysis was part of the Community-Acquired Pneumonia immunization Trial in Adults (CAPiTA); a double blind, randomized, placebo-controlled trial in 84 496 immunocompetent individuals aged ≥65 years...
October 16, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29043419/computed-tomography-in-children-with-community-acquired-pneumonia
#12
REVIEW
Savvas Andronikou, Pierre Goussard, Erich Sorantin
Diagnostic imaging plays a significant role in both the diagnosis and treatment of complications of pneumonia in children and chest radiography is the imaging modality of choice. Computed tomography (CT) on the other hand, is not currently a first-line imaging tool for children with suspected uncomplicated community-acquired pneumonia and is largely reserved for when complications of pneumonia are suspected or there is difficulty in differentiating pneumonia from other pathology. This review outlines the situations where CT needs to be considered in children with pneumonia, describes the imaging features of the parenchymal and pleural complications of pneumonia, discusses how CT may have a wider role in developing countries where human immunodeficiency virus (HIV) and tuberculosis are prevalent, makes note of the role of CT scanning for identifying missed foreign body aspiration and, lastly, addresses radiation concerns...
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29036724/etiology-and-clinical-characteristics-of-community-acquired-pneumonia-with-airway-malacia-in-children
#13
Wang Yu-Qing, Hao Chuang-Li, Ji Wei, Chen Zheng-Rong, Zhang Xin-Xin, Gu Wen-Jing
Objective: The objective of this article is to study the etiology of community-acquired pneumonia in children with airway malacia. Methods: We retrospectively reviewed the medical records of 428 pneumonia patients. All patients underwent bronchoscopy, and bronchoalveolar lavage samples were processed for microbiological assessment. Results: In a total of 428 cases reviewed, 60 were found to have airway malacia. Pathogens were identified in 44 of the 60 specimens (73...
September 27, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29031867/influenza-is-more-common-than-middle-east-respiratory-syndrome-coronavirus-mers-cov-among-hospitalized-adult-saudi-patients
#14
Jaffar A Al-Tawfiq, Ali A Rabaan, Kareem Hinedi
BACKGROUND: Since the initial description of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), we adopted a systematic process of screening patients admitted with community acquired pneumonia. Here, we report the result of the surveillance activity in a general hospital in Saudi Arabia over a four year period. MATERIALS AND METHODS: All admitted patients with community acquired pneumonia from 2012 to 2016 were tested for MERS-CoV. In addition, testing for influenza viruses was carried out starting April 2015...
October 12, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29028159/serologically-diagnosed-acute-human-bocavirus-1-infection-in-childhood-community-acquired-pneumonia
#15
Amanda C Nascimento-Carvalho, Ana-Luisa Vilas-Boas, Maria-Socorro H Fontoura, Man Xu, Tytti Vuorinen, Maria Söderlund-Venermo, Olli Ruuskanen, Cristiana M Nascimento-Carvalho
AIM: To assess the role of human bocavirus 1 (HBoV1) as a causative agent of non-severe community-acquired pneumonia (CAP) in children. METHODS: Patients aged 2-59 months with non-severe CAP (respiratory complaints and radiographic pulmonary infiltrate/consolidation) attending a University Hospital in Salvador, Brazil were enrolled in a prospective cohort. From 820 recruited children in a clinical trial (ClinicalTrials.gov NCT01200706), nasopharyngeal aspirate (NPA), and acute and convalescent serum samples were obtained from 759 (92...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29018819/the-clinical-significance-of-filmarray-respiratory-panel-in-diagnosing-community-acquired-pneumonia
#16
Huanzhu Chen, Huilan Weng, Meirui Lin, Ping He, Yazhen Li, Qingdong Xie, Changwen Ke, Xiaoyang Jiao
AIM: FilmArray Respiratory Panel (FilmArray RP) test is an emerging diagnostic method in fast detecting multiple respiratory pathogens; the methodology and clinical significance of FilmArray RP in community-acquired pneumonia (CAP) diagnosis were evaluated in this study. METHODS: Specimens from 74 patients with CAP were analyzed and compared using FilmArray RP, traditional multiple PCR assay, bacterial (or fungal) culture, and serological detection. RESULTS: FilmArray RP and multiplex PCR showed 100% coincidence rate in detecting coronaviruses 229E, OC43, HKU1, and NL63, human metapneumovirus, influenza A and B, and parainfluenza viruses (PIV1, PIV2, and PIV4)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28975629/etiology-of-community-acquired-pneumonia-in-1500-hospitalized-children
#17
Hao Oumei, Wang Xuefeng, Liu Jianping, Shen Kunling, Ma Rong, Cui Zhenze, Deng Li, Yan Huimin, Wang Lining, Liu Zhaolan, Li Xinmin, Xu Hua, Jiang Zhiyan, Li Yanning, Huang Yan, Zhang Baoqing, Feng Xiaochun, He Chunhui, Jiang Yonghong, Zhao Xue, Wei Wei, Wang Zi
Childhood community-acquired pneumonia (CAP) is a common illness; however, comprehensive studies of hospitalizations for CAP among children in China based on prospective and multicenter data collection are limited. The aim of this investigation was to determine the respiratory pathogens responsible for CAP in hospitalized children. From January to December 2015, oropharyngeal swabs and blood serum were collected from hospitalized children with CAP symptoms ranging in age from 6 months to 14 years at 10 hospitals across China...
October 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28944408/etiology-of-childhood-pneumonia-what-we-know-and-what-we-need-to-know-based-on-5th-dr-ic-verma-excellence-oration-award
#18
Joseph L Mathew
Childhood community acquired pneumonia continues to be an important clinical problem at the individual, institutional and community levels. Determination of microbial etiology is critical to develop evidence-based management (therapeutic and prophylactic) decisions. For decades, the approach to this relied on culture of lung aspirate specimens obtained from children with radiographically confirmed pneumonia, before administering antibiotics. Such studies revealed the major bacteria associated with pneumonia, prompting the World Health Organization to develop a highly sensitive clinical definition of pneumonia and advocate empiric antibiotic therapy; in order to save lives (focusing on community settings lacking resources for diagnostic tests)...
September 25, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28934425/human-bocavirus-capsid-messenger-rna-detection-in-children-with-pneumonia
#19
MULTICENTER STUDY
Robert Schlaberg, Krow Ampofo, Keith D Tardif, Chris Stockmann, Keith E Simmon, Weston Hymas, Steven Flygare, Brett Kennedy, Anne Blaschke, Karen Eilbeck, Mark Yandell, Jon A McCullers, Derek J Williams, Kathryn Edwards, Sandra R Arnold, Anna Bramley, Seema Jain, Andrew T Pavia
Background: The role of human bocavirus (HBoV) in respiratory illness is uncertain. HBoV genomic DNA is frequently detected in both ill and healthy children. We hypothesized that spliced viral capsid messenger RNA (mRNA) produced during active replication might be a better marker for acute infection. Methods: As part of the Etiology of Pneumonia in the Community (EPIC) study, children aged <18 years who were hospitalized with community-acquired pneumonia (CAP) and children asymptomatic at the time of elective outpatient surgery (controls) were enrolled...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28929964/-investigation-of-bacterial-and-viral-etiology-in-community-acquired-central-nervous-system-infections-with-molecular-methods
#20
Hasip Kahraman, Alper Tünger, Şebnem Şenol, Hörü Gazi, Meltem Avcı, Bahar Örmen, Nesrin Türker, Sabri Atalay, Şükran Köse, Sercan Ulusoy, Meltem Işıkgöz Taşbakan, Oğuz Reşat Sipahi, Tansu Yamazhan, Zeynep Gülay, Sema Alp Çavuş, Hüsnü Pullukçu
In this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (PCR) methods. Patients hospitalized with central nervous system infections between April 2012 and February 2014 were enrolled in the study. Demographic and clinical information of the patients were collected prospectively. Cerebrospinal fluid (CSF) samples of the patients were examined by standart bacteriological culture methods, bacterial multiplex PCR (Seeplex meningitis-B ACE Detection (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Listeria monocytogenes, Group B streptococci) and viral multiplex PCR (Seeplex meningitis-V1 ACE Detection kits herpes simplex virus-1 (HSV1), herpes simplex virus-2 (HSV2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein Barr virus (EBV) and human herpes virus 6 (HHV6)) (Seeplex meningitis-V2 ACE Detection kit (enteroviruses))...
July 2017: Mikrobiyoloji Bülteni
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