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community-acquired pneumonia AND virus

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https://www.readbyqxmd.com/read/27852281/viral-bacterial-coinfection-affects-the-presentation-and-alters-the-prognosis-of-severe-community-acquired-pneumonia
#1
Guillaume Voiriot, Benoit Visseaux, Johana Cohen, Liem Binh Luong Nguyen, Mathilde Neuville, Caroline Morbieu, Charles Burdet, Aguila Radjou, François-Xavier Lescure, Roland Smonig, Laurence Armand-Lefèvre, Bruno Mourvillier, Yazdan Yazdanpanah, Jean-Francois Soubirou, Stephane Ruckly, Nadhira Houhou-Fidouh, Jean-François Timsit
BACKGROUND: Multiplex polymerase chain reaction (mPCR) enables recovery of viruses from airways of patients with community-acquired pneumonia (CAP), although their clinical impact remains uncertain. METHODS: Among consecutive adult patients who had undergone a mPCR within 72 hours following their admission to one intensive care unit (ICU), we retrospectively included those with a final diagnosis of CAP. Four etiology groups were clustered: bacterial, viral, mixed (viral-bacterial) and no etiology...
October 25, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27848998/fatal-community-acquired-pneumonia-in-children-caused-by-re-emergent-human-adenovirus-7d-associated-with-higher-severity-of-illness-and-fatality-rate
#2
Zhiwu Yu, Zhiwei Zeng, Jing Zhang, Yuxian Pan, Manjun Chen, Yonghui Guo, Nan Yu, James Chodosh, Ning Fu, Xiaoyan Che, Qiwei Zhang
Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), such as community-acquired pneumonia. HAdV-7d, a re-emergent genomic variant, has been recently reported in Asia and the United States after a several-decade absence. However, whether HAdV-7d is associated with higher severity than other types is currently unclear. In this study, the clinical and epidemiological investigation showed that fever, cough, and sore throat were the three most common respiratory symptoms of HAdV infections...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27846213/sensitivity-and-specificity-of-soluble-triggering-receptor-expressed-on-myeloid-cells-1-midregional-proatrial-natriuretic-peptide-and-midregional-proadrenomedullin-for-distinguishing-etiology-and-to-assess-severity-in-community-acquired-pneumonia
#3
Susanna Esposito, Maria Di Gangi, Fabio Cardinale, Eugenio Baraldi, Ilaria Corsini, Liviana Da Dalt, Pier Angelo Tovo, Antonio Correra, Alberto Villani, Oliviero Sacco, Laura Tenero, Piera Dones, Monia Gambino, Alberto Zampiero, Nicola Principi
STUDY DESIGN: This study aimed to evaluate the diagnostic accuracy of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), midregional proatrial natriuretic peptide (MR-proANP) and midregional proadrenomedullin (MR-proADM) to distinguish bacterial from viral community-acquired pneumonia (CAP) and to identify severe cases in children hospitalized for radiologically confirmed CAP. Index test results were compared with those derived from routine diagnostic tests, i.e., white blood cell (WBC) counts, neutrophil percentages, and serum C-reactive protein (CRP) and procalcitonin (PCT) levels...
2016: PloS One
https://www.readbyqxmd.com/read/27795341/serology-enhances-molecular-diagnosis-of-respiratory-virus-infections-other-than-influenza-in-children-and-adults-hospitalized-with-community-acquired-pneumonia
#4
Yange Zhang, Senthilkumar K Sakthivel, Anna Bramley, Seema Jain, Amber Haynes, James D Chappell, Weston Hymas, Noel Lenny, Anami Patel, Chao Qi, Krow Ampofo, Sandra R Arnold, Wesley H Self, Derek J Williams, David Hillyard, Evan J Anderson, Carlos G Grijalva, Yuwei Zhu, Richard G Wunderink, Kathryn M Edwards, Andrew T Pavia, Jonathan A McCullers, Dean D Erdman
Both molecular and serological assays have been used previously to determine the etiology of community-acquired pneumonia (CAP). However, the correlation of these methods and added diagnostic value of serology has not been fully evaluated. Using data from patients enrolled in the Centers for Disease Control and Prevention Etiology of Pneumonia in the Community (EPIC) study, we compared real-time RT-PCR and serology for diagnosis of respiratory syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza viruses 1-3 (PIV) and adenovirus (AdV) infections...
October 19, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27788254/microorganisms-causing-community-acquired-acute-bronchitis-the-role-of-bacterial-infection
#5
Ji Young Park, Sunghoon Park, Sun Hwa Lee, Myung Goo Lee, Yong Bum Park, Kil Chan Oh, Jae-Myung Lee, Do Il Kim, Ki-Hyun Seo, Kyeong-Cheol Shin, Kwang Ha Yoo, Yongchun Ko, Seung Hun Jang, Ki-Suck Jung, Yong Il Hwang
BACKGROUND: Although acute bronchitis is quite common, there is relatively limited information regarding the microorganisms that are involved in this illness. METHODS: We performed a prospective study of acute bronchitis at 31 hospitals and clinics in Korea from July 2011 to June 2012. Sputum specimens were collected for polymerase chain reaction (PCR) and culture of microorganisms. RESULTS: Of the 811 enrolled patients, 291 had acceptable sputum specimens that were included for analysis of the etiologic distribution...
2016: PloS One
https://www.readbyqxmd.com/read/27773623/-increasing-incidence-of-community-acquired-pneumonia-caused-by-atypical-microorganisms
#6
M A Tazón-Varela, H Alonso-Valle, P Muñoz-Cacho, J Gallo-Terán, X Piris-García, L A Pérez-Mier
INTRODUCTION: Knowing the most common microorganisms in our environment can help us to make proper empirical treatment decisions. The aim is to identify those microorganisms causing community-acquired pneumonia. PATIENTS AND METHODS: An observational, descriptive and prospective study was conducted, including patients over 14 years with a clinical and radiographic diagnosis of community-acquired pneumonia during a 383 consecutive day period. A record was made of sociodemographic variables, personal history, prognostic severity scales, progress, and pathogenic agents...
October 20, 2016: Semergen
https://www.readbyqxmd.com/read/27766169/microbial-etiology-of-community-acquired-pneumonia-among-infants-and-children-admitted-to-the-pediatric-hospital-ain-shams-university
#7
Magda Yehia El Seify, Eman Mahmoud Fouda, Hanan Mohamed Ibrahim, Maha Muhammad Fathy, Asmaa Al Husseiny Ahmed, Walaa Shawky Khater, Noha Nagi Mohammed Salah El Deen, Heba Galal Mohamed Abouzeid, Nancy Riyad Ahmed Hegazy, Heba Salah Sayed Elbanna
BACKGROUND: While recognizing the etiology of community-acquired pneumonia is necessary for formulating local antimicrobial guidelines, limited data is published about this etiology in Egyptian pediatric patients. OBJECTIVES: To determine the frequency of bacterial and viral pathogens causing community-acquired pneumonia (CAP) among immunocompetent Egyptian infants and preschool children. METHODS: Ninety infants and preschool-age children admitted to our hospital with CAP were prospectively included in the study...
September 29, 2016: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/27757026/vitamin-e-administration-may-decrease-the-incidence-of-pneumonia-in-elderly-males
#8
Harri Hemilä
BACKGROUND: Vitamin E has influenced the immune system in laboratory studies. Dozens of animal experiments have found that vitamin E offered protection against infections caused by viruses and bacteria. Previously, significant heterogeneity was found in the effect of vitamin E supplementation on pneumonia in humans. The aim of this study was to examine how the effect of vitamin E on pneumonia risk depends on age. METHODS: Secondary analysis of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study in Finland, 1985-1993, was performed...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27755118/community-acquired-pneumonia-in-the-post-13-valent-pneumococcal-conjugate-vaccine-era
#9
Erin E Shaughnessy, Erika L Stalets, Samir S Shah
PURPOSE OF REVIEW: This review covers the outpatient management of pediatric community-acquired pneumonia (CAP), discussing the changing microbiology of CAP since the introduction of the 13-valent pneumococcal conjugate vaccine in 2010, and providing an overview of national guideline recommendations for diagnostic evaluation and treatment. RECENT FINDINGS: Rates of invasive pneumococcal disease and pneumococcal antibiotic resistance have plummeted since widespread 13-valent pneumococcal conjugate vaccine immunization...
December 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27737646/maternal-vitamin-d-supplementation-during-pregnancy-and-lactation-to-prevent-acute-respiratory-infections-in-infancy-in-dhaka-bangladesh-mdari-trial-protocol-for-a-prospective-cohort-study-nested-within-a-randomized-controlled-trial
#10
Shaun K Morris, Lisa G Pell, Mohammed Ziaur Rahman, Michelle C Dimitris, Abdullah Mahmud, M Munirul Islam, Tahmeed Ahmed, Eleanor Pullenayegum, Tahmid Kashem, Shaila S Shanta, Jonathan Gubbay, Eszter Papp, Michelle Science, Stanley Zlotkin, Daniel E Roth
BACKGROUND: Early infancy is a high-risk period for severe acute respiratory infection (ARI), particularly in low-income countries with resource-limited health systems. Lower respiratory tract infection (LRTI) is commonly preceded by upper respiratory infection (URTI), and often caused by respiratory syncytial virus (RSV), influenza and other common community-acquired viral pathogens. Vitamin D status is a candidate modifiable early-life determinant of the host antiviral immune response and thus may influence the risk of ARI-associated morbidity in high-risk populations...
October 13, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27714467/is-the-role-of-rhinoviruses-as-causative-agents-of-pediatric-community-acquired-pneumonia-over-estimated
#11
Tatyana V Spichak, Svetlana B Yatsyshina, Lubov К Кatosova, Svetlana S Кim, Matti O Korppi
: The role that rhinoviruses, enteroviruses, parainfluenza viruses, coronaviruses and human bocavirus play in pediatric pneumonia is insufficiently studied. We used polymerase chain reaction (PCR) to study 9 virus groups, including 16 different viruses or viral strains, in 56 ambulatory children with radiologically confirmed community-acquired pneumonia (CAP). The same tests were carried out on 474 apparently healthy control children of the same age and sex. The mean age of children with CAP was 6...
October 6, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27681877/community-acquired-respiratory-virus-infections-in-cancer-patients-guideline-on-diagnosis-and-management-by-the-infectious-diseases-working-party%C3%A2-of-the-german-society-for-haematology-and-medical-oncology
#12
Marie von Lilienfeld-Toal, Annemarie Berger, Maximilian Christopeit, Marcus Hentrich, Claus Peter Heussel, Jana Kalkreuth, Michael Klein, Matthias Kochanek, Olaf Penack, Elke Hauf, Christina Rieger, Gerda Silling, Maria Vehreschild, Thomas Weber, Hans-Heinrich Wolf, Nicola Lehners, Enrico Schalk, Karin Mayer
BACKGROUND: Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly. METHODS: A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27659204/risk-factors-for-community-acquired-pneumonia-in-children-under-five-years-of-age-in-the-post-pneumococcal-conjugate-vaccine-era-in-brazil-a-case-control-study
#13
Eduardo Jorge da Fonseca Lima, Maria Júlia Gonçalves Mello, Maria de Fátima Pessoa Militão de Albuquerque, Maria Isabella Londres Lopes, George Henrique Cordeiro Serra, Debora Ellen Pessoa Lima, Jailson Barros Correia
BACKGROUND: Pneumonia plays an important role in children's morbidity and mortality. In Brazil, epidemiological and social changes occurred concomitantly with the universal introduction of the 10-valent pneumococcal conjugate vaccine. This study identified risk factors for pneumonia following the implementation of a pneumococcal vaccination program. METHODS: A hospital-based, case-control study involving incident cases of pneumonia in children aged 1-59 months was conducted between October 2010 and September 2013 at a tertiary hospital in northeastern Brazil...
September 22, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27649510/the-use-of-polymerase-chain-reaction-amplification-for-the-detection-of-viruses-and-bacteria-in-severe-community-acquired-pneumonia
#14
Wen Ting Siow, Evelyn Siew-Chuan Koay, Chun Kiat Lee, Hong Kai Lee, Venetia Ong, Wang Jee Ngerng, Hui Fang Lim, Adeline Tan, Julian Wei-Tze Tang, Jason Phua
BACKGROUND: Pathogens are often not identified in severe community-acquired pneumonia (CAP), and the few studies using polymerase chain reaction (PCR) techniques for virus detection are from temperate countries. OBJECTIVE: This study assesses if PCR amplification improves virus and bacteria detection, and if viral infection contributes to mortality in severe CAP in a tropical setting, where respiratory pathogens have less well-defined seasonality. METHODS: In this cohort study of patients with severe CAP in an intensive care unit, endotracheal aspirates for intubated patients and nasopharyngeal swabs for non-intubated patients were sent for PCR amplification for respiratory viruses...
September 21, 2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27627439/a-gexp-based-assay-for-simultaneous-detection-of-multiple-viruses-in-hospitalized-children-with-community-acquired-pneumonia
#15
Le Wang, Mengchuan Zhao, Zhongren Shi, Zhishan Feng, Weiwei Guo, Shuo Yang, Lanping Liu, Guixia Li
The GeXP-based assay has recently been developed for simultaneous detection of multiple pathogens. So far, the application of the GeXP assay to test larger clinical samples has hardly been reported. Community-acquired pneumonia (CAP) is the leading cause of death in children worldwide and a substantial proportion of childhood CAP is caused by viruses. Rapid and accurate diagnosis of virus infection is important for the clinical management of CAP. In this study, we explored the GeXP assay for simultaneous detection of 20 types/subtypes of viruses in hospitalized children with CAP...
2016: PloS One
https://www.readbyqxmd.com/read/27620382/birds-of-a-feather-an-uncommon-cause-of-pneumonia-and-meningoencephalitis
#16
Anne-Marie Ionescu, Divya Khare, Jay Kavi
A 61-year-old man was admitted with a 1-week history of influenza-like symptoms during a period of increased influenza virus activity. He soon developed type 2 respiratory failure and became increasingly drowsy. He later suffered a convulsive episode in the intensive care unit (ICU) which self-terminated. Initial clinical findings suggested community-acquired pneumonia and meningoencephalitis. However, a detailed history revealed that he was a pet bird-keeper, which raised a suspicion of ornithosis. Chlamydia psittaci DNA was detected in sputum by PCR...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27567093/clinical-practice-of-respiratory-virus-diagnostics-in-critically-ill-patients-with-a-suspected-pneumonia-a-prospective-observational-study
#17
Frank van Someren Gréve, David S Y Ong, Olaf L Cremer, Marc J M Bonten, Lieuwe D J Bos, Menno D de Jong, Marcus J Schultz, Nicole P Juffermans
BACKGROUND: Clinical guidelines suggest testing for respiratory viruses during the influenza season, but are unclear which categories of patients on the intensive care unit (ICU) should be tested. OBJECTIVE: We described the clinical practice of diagnostic testing for respiratory virus infections in patients presenting to ICU with suspected community-acquired pneumonia (CAP) or hospital-acquired pneumonia (HAP). STUDY DESIGN: Prospective observational study in consecutive CAP and HAP patients with an ICU stay of more than 24h in two tertiary care hospitals in The Netherlands, from 2011 to December 2013...
October 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27467538/graft-loss-and-clad-onset-is-hastened-by-viral-pneumonia-after-lung-transplantation
#18
Paul R Allyn, Erin L Duffy, Romney M Humphries, Patil Injean, S Samuel Weigt, Rajan Saggar, Michael Y Shino, Joseph P Lynch, Abbas Ardehali, Bernard Kubak, Chi-Hong Tseng, John A Belperio, David J Ross, Aric L Gregson
BACKGROUND: Community-acquired respiratory virus (CARV) infections occur frequently after lung transplantation and may adversely impact outcomes. We hypothesized that while asymptomatic carriage would not increase the risk of chronic lung allograft dysfunction (CLAD) and graft loss, severe infection would. METHODS: All lung transplant cases between January 2000 and July 2013 performed at our center were reviewed for respiratory viral samples. Each isolation of virus was classified according to clinical level of severity: asymptomatic, symptomatic without pneumonia, and viral pneumonia...
November 2016: Transplantation
https://www.readbyqxmd.com/read/27449898/comparison-of-the-frequency-of-bacterial-and-viral-infections-among-children-with-community-acquired-pneumonia-hospitalized-across-distinct-severity-categories-a-prospective-cross-sectional-study
#19
Amanda C Nascimento-Carvalho, Olli Ruuskanen, Cristiana M Nascimento-Carvalho
BACKGROUND: The comparison of the frequencies of bacterial and viral infections among children with community-acquired pneumonia (CAP) admitted in distinct severity categories, in an original study, is lacking in literature to-date. We aimed to achieve this goal. METHODS: Children aged 2-59-months-old hospitalized with CAP were included in this prospective study in Salvador, Brazil. Clinical data and biological samples were collected to investigate 11 viruses and 8 bacteria...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27439403/measurement-of-lipocalin-2-and-syndecan-4-levels-to-differentiate-bacterial-from-viral-infection-in-children-with-community-acquired-pneumonia
#20
Susanna Esposito, Sonia Bianchini, Monia Gambino, Barbara Madini, Giada Di Pietro, Giulia Umbrello, Maria Lory Presicce, Luca Ruggiero, Leonardo Terranova, Nicola Principi
BACKGROUND: In this study, we evaluated the lipocalin-2 (LIP2) and syndecan-4 (SYN4) levels in children who were hospitalized for radiologically confirmed CAP in order to differentiate bacterial from viral infection. The results regarding the LIP2 and SYN4 diagnostic outcomes were compared with the white blood cell (WBC) count and C reactive protein (CRP) levels. METHODS: A total of 110 children <14 years old who were hospitalized for radiologically confirmed CAP were enrolled...
2016: BMC Pulmonary Medicine
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