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https://www.readbyqxmd.com/read/28918083/topical-fluorometholone-treatment-and-desiccating-stress-change-inflammatory-protein-expression-in-tears
#1
Janika Nättinen, Antti Jylhä, Ulla Aapola, Amalia Enríquez-de-Salamanca, José Pinto-Fraga, Alberto López-Miguel, María J González-García, Michael E Stern, Margarita Calonge, Lei Zhou, Matti Nykter, Hannu Uusitalo, Roger Beuerman
PURPOSE: It was hypothesized that tear protein biomarkers could predict the effects of topical steroid treatment and desiccating stress in patients with dry eye disease (DED). To test this concept, a randomized, double-masked, controlled clinical trial with 41 patients was conducted. METHODS: The patients were treated topically with either 0.1% fluorometholone (FML) or polyvinyl alcohol (PA). Tear samples were collected using 1 μl glass capillaries at recruitment into the study and after a 3-week treatment period, both before and after 2 h exposure to desiccating stress, in a controlled environment chamber...
September 13, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28913997/additive-effect-of-oral-steroid-with-topical-nonsteroidal-anti-inflammatory-drug-for-preventing-cystoid-macular-edema-after-cataract-surgery-in-patients-with-epiretinal-membrane
#2
Seonghwan Kim, Mee Kum Kim, Won Ryang Wee
PURPOSE: To investigate the additive effect of oral steroid with topical nonsteroidal anti-inflammatory drug (NSAID) on cystoid macular edema (CME) in patients with epiretinal membrane (ERM) after cataract surgery. METHODS: Medical records of subjects who underwent uneventful cataract surgery (n = 1,349) were retrospectively reviewed; among these patients, those with pre-existing ERM (n = 81) were included. Patients were divided into two groups: one group had postoperative administration of oral steroid for 1 week (n = 45) and the other group did not have oral steroid administration (n = 36)...
August 18, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28911799/effects-of-glucocorticoids-on-stratum-corneum-lipids-and-function-in-human-skin-a-detailed-lipidomic-analysis
#3
Mads A Røpke, Cristina Alonso, Sora Jung, Hanne Norsgaard, Claudia Richter, Maxim E Darvin, Thomas Litman, Annika Vogt, Jürgen Lademann, Ulrike Blume-Peytavi, Jan Kottner
BACKGROUND: Topical glucocorticoids (GCs) are known to induce atrophy of human skin including thinning of epidermal and dermal compartments by influencing keratinocyte proliferation and synthesis of extracellular matrix proteins. GCs are also known to reduce skin barrier integrity but little is known about the changes in lipid composition in human skin following topical administration of GCs. OBJECTIVE: This study investigated the effects of GCs on stratum corneum (SC) function and lipid profile of human skin in vivo...
August 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28906049/alitretinoin-treatment-of-lichen-amyloidosis
#4
Won Seon Koh, Eui Hyun Oh, Jeong Eun Kim, Young Suck Ro
Lichen amyloidosis (LA) is characterized by the deposition of amyloid that may respond to chronic scratching that may be secondary to atopic dermatitis, stasis dermatitis, or interface dermatitis. Despite the development of several therapeutic strategies, including topical steroids, oral antihistamines, cyclosporine, and retinoids, an effective treatment for LA has not been established. A 49-year-old woman who has been treated irregularly for atopic dermatitis for 7 years presented with localized brownish papules on the left forearm and right elbow...
September 14, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28905834/microsporidial-infection-masquerading-as-graft-rejection-post-descemet-s-stripping-automated-endothelial-keratoplasty
#5
Lumbini Devi, N Venkatesh Prajna, Muthiah Srinivasan, Naveen Radhakrishnan, Manoranjan Das
A 51-year-old immunocompetent male with a history of Fuchs' endothelial dystrophy and immature cataract who underwent Descemet's stripping automated endothelial keratoplasty with intraocular lens implantation in both eyes presented with redness and defective vision of 1-day duration in his left eye. Slit lamp examination revealed coarse superficial punctate lesions with graft edema. He was diagnosed with acute graft rejection and treated with topical steroids. Two days later, symptoms worsened in his left eye with the involvement of his right eye showing a similar clinical picture...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28900068/-efficacy-of-topical-agents-for-symptomatic-treatment-of-rotigotine-patch-induced-skin-disorders
#6
Yuki Yasutaka, Shinsuke Fujioka, Hirotomo Shibaguchi, Fumiaki Kiyomi, Koyomi Hara, Kentaro Ogata, Yoshio Tsuboi, Hidetoshi Kamimura
Since the effect of a percutaneous absorption-type dopamine agonist (DA) preparation, rotigotine patch, stably persists by once-a-day application, this dosage form is appropriate for Parkinson's disease patients showing levodopa induced wearing off phenomenon. On the other hand, skin disorders, mainly application site reaction, are characteristic problems associated with use of the patch. In this study, to clarify the influence of a topical agent used to prevent or treat rotigotine patch-induced skin disorder on continuation of the patch application, patients who started rotigotine patch application at our hospital were retrospectively surveyed...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28895668/concepts-and-controversies-in-the-treatment-of-cutaneous-lichen-planus-a-review
#7
Charles Puza, Adela R Cardones
Cutaneous lichen planus (CLP) is a chronic autoimmune disease classically associated with severely pruritic, polygonal, violaceous, flat-topped papules and plaques. Subtypes such as hypertrophic and bullous lichen planus and lichen planus pigmentosus have been described. Treatment can be challenging, and prospective controlled studies are lacking. Corticosteroids remain the major options for topical and systemic treatment, although some non-steroidal options exist. Phototherapy, especially with narrow band ultraviolet B (NB-UVB), is effective, but caution must be taken because of the risk of keobnerization...
September 12, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28895370/eosinophilic-esophagitis-current-evidence-based-diagnosis-and-treatment-in-children-and-adults
#8
Alfredo J Lucendo
Eosinophilic esophagitis (EoE) is a disease caused by an immune response to food antigens in contact with the esophageal mucosa that has arisen as a common disorder in current clinical practice. Its diagnosis is defined by the combination of symptoms of esophageal dysfunction and inflammation of the esophageal mucosa predominantly by eosinophils. Its chronic course and frequent progression to subepithelial fibrosis leading to strictures and narrow-caliber esophagus indicate the need for treatment. Information provided by recent clinical trials and systematic reviews allowed for the development of new clinical guidelines, endorsed by several European scientific societies...
September 11, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28895213/supramolecular-synthon-approach-in-developing-anti-inflammatory-topical-gel-for-in-vivo-self-delivery
#9
Parthasarathi Dastidar, Rajdip Roy
A new series of TBA salt of various non-steroidal-anti-inflammatory-drugs (NSAIDs) was synthesized and characterized. Nearly 90% of the salts displayed remarkable gelation ability with various solvents including methyl salicylate. SXRD revealed the existence of 1D PAM synthon in the gelator salts. Structure-property correlation studies based on SXRD and PXRD data established the presence of the 1D PAM synthon in the bulk salts as well as in the corresponding xerogels. A parallel series of salts derived from TRIS and the same set of NSAIDs displayed poor gelation ability (only 33% of the salts)...
September 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28895150/chemosensory-function-before-and-after-multimodal-treatment-in-chronic-rhinosinusitis-patients
#10
Ute Walliczek-Dworschak, Robert Pellegrino, Franziska Taube, Christian A Mueller, Boris Alexander Stuck, Philipp Dworschak, Christian Güldner, Silke Steinbach
OBJECTIVES/HYPOTHESIS: Olfactory dysfunction is common among the general population, with chronic rhinosinusitis (CRS) as one of the leading causes. Patients affected by CRS often report changes in taste sensations; however, quantitative measurements have not been performed to date. Therefore, the present study aimed to investigate gustatory and olfactory function in CRS patients prior to and after multimodal treatment. STUDY DESIGN: Prospective cohort study. METHODS: Twenty-one patients suffering from CRS with nasal polyps (14 male, seven female) with a mean age of 48 ± 15 years were included in the study...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28890990/child-with-allergies-or-allergic-reactions
#11
REVIEW
Reshma A, Arun K Baranwal
Incidence of allergic disorders in children has increased significantly over time due to environmental and life-style changes. These include allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergies, bronchial asthma, drug allergies, insect bites and anaphylaxis; most being IgE-mediated type 1 hypersensitivity reactions to common environmental and food antigens. Although most of them are self-limiting, they may adversely affect the quality of life and sometimes become life-threatening as well...
September 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28890236/adenovirus-initiative-study-in-epidemiology-advise-results-of-a-multicentric-epidemiology-study-in-spain
#12
A M Muñoz-Hernández, B Duquesroix, J M Benítez-Del-Castillo
OBJECTIVE: Non-interventional, observational, epidemiology study to assess clinical characteristics and frequency of adenovirus conjunctivitis diagnosed by AdenoPlus(®) in patients who presented with signs and symptoms of acute conjunctivitis. Safety aspects during use of the test were analyzed as well. METHOD: This analysis presents the data obtained from the 386 patients enrolled in Spain. Patients had to present with acute signs and symptoms of conjunctivitis ≤7days...
September 7, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28887823/variation-of-the-epidermal-expression-of-glucocorticoid-receptor-beta-as-potential-predictive-marker-of-bullous-pemphigoid-outcome
#13
Adrien Brulefert, Sébastien Le Jan, Julie Plée, Anne Durlach, Philippe Bernard, Frank Antonicelli, Aurélie Trussardi-Régnier
Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease in Western countries. Although topical and/or systemic glucocorticoids treatment efficacy is widely recognized, up to 30% of patients with BP may undergo a relapse during the first year of treatment. We investigated the protein expression of the total glucocorticoid receptor and GRβ isoform in the skin biopsy specimens from patients with BP, and wondered whether such investigation at baseline provided a tool to predict disease outcome...
September 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28884078/effects-of-topical-flurbiprofen-sodium-diclofenac-sodium-ketorolac-tromethamine-and-benzalkonium-chloride-on-corneal-sensitivity-in-normal-dogs
#14
Raquel de Araújo Cantarella, Juliana Kravetz de Oliveira, Daniel M Dorbandt, Fabiano Montiani-Ferreira
To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.5%) and benzalkonium chloride 0.01%. Six healthy mixed breed dogs from the same litter were used in two different stages. First, one drop of flurbiprofen sodium 0.03% and diclofenac sodium 0.1% in each eye; second, one drop of ketorolac tromethamine 0...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28874240/-review-of-online-prescriptions-of-topical-steroids-for-an-obese-boy-with-iatrogenic-cushing-s-syndrome
#15
Sina Dalby, Inge Østergaard
A 14-year-old boy with obesity developed iatrogenic Cushing's syndrome after having received topical steroid therapy for psoriasis. The diagnosis was suspected when he developed striae, moon face and stunted growth. A review of the Danish online registration of prescriptions: Shared Medicine Card, revealed that an amount of 5.1 kg topical steroids had been prescribed during a period of twelve months. Blood tests showed stunted cortisol release. Primary obesity in children is associated with increased growth...
August 28, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28867463/oral-lichen-sclerosus-a-review-of-clinical-presentation-treatment-and-clinical-outcomes
#16
REVIEW
Stephanie L Bevans, Jordan M Keeley, Naveed Sami
OBJECTIVE: The aim of this study was to evaluate the disease involvement, treatment and response, and malignant potential of oral lichen sclerosus (LS). STUDY DESIGN: We conducted a review of the literature of 37 cases of oral LS. We looked specifically for the following data: patient demographic characteristics, disease involvement, treatment, response to treatment, duration of follow-up, symptoms, risk factors for oral malignancy, and malignant transformation...
August 3, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28859690/targeted-anti-staphylococcal-therapy-with-endolysins-in-atopic-dermatitis-and-the-effect-on-steroid-use-disease-severity-and-the-microbiome-study-protocol-for-a-randomized-controlled-trial-maas-trial
#17
Joan Totté, Jill de Wit, Luba Pardo, Frank Schuren, Martijn van Doorn, Suzanne Pasmans
BACKGROUND: Atopic dermatitis (AD) is associated with reduced skin microbial diversity and overgrowth of Staphylococcus (S.) aureus. However, the importance of S. aureus colonisation in the complex pathogenesis remains unclear and studies on the effect of anti-staphylococcal therapy in non-infected AD show contradictory results. Long-term interventions against S. aureus might be needed to restore the microbial balance, but carry the risk of bacterial resistance induction. Staphefekt, an engineered bacteriophage endolysin, specifically kills S...
August 31, 2017: Trials
https://www.readbyqxmd.com/read/28853058/pharmacological-management-of-chronic-rhinosinusitis-current-and-evolving-treatments
#18
Daniel M Beswick, Stacey T Gray, Timothy L Smith
Chronic rhinosinusitis (CRS) is an inflammatory sinonasal condition with multiple etiologic factors that is associated with a vast economic cost. Treatment is most frequently pharmacologic and has centered on agents that ameliorate inflammation, decrease bacterial or pathogen load, and facilitate egress of mucus or purulence from the sinonasal cavity. Nasal saline irrigations, topical nasal steroids, certain antibiotics, and systemic steroids have shown some efficacy in the management of CRS. Recently, biologic therapeutics that target specific inflammatory pathways associated with subsets of CRS have been developed and evaluated...
August 29, 2017: Drugs
https://www.readbyqxmd.com/read/28837508/every-other-day-dosing-of-oral-viscous-budesonide-is-not-effective-in-the-management-of-eosinophlic-esophagitis
#19
Eitan Rubinstein, Elizabeth E Hait, Paul D Mitchell, John J Lee
INTRODUCTION: Eosinophilic esophagitis (EoE) is a clinicopathologic disorder characterized histologically by esophageal eosinophilia. Oral viscous budesonide (OVB) is an effective treatment with remission rates reported between 55 and 87%; however, topical corticosteroids are associated with increased risk of candidal esophagitis and adrenal suppression. Attempts to decrease the daily dose of topical steroids have resulted in disease relapse. The objective of this study was to determine whether or not reducing the frequency of OVB administration would be effective in controlling esophageal eosinophilia in children and adolescents...
August 23, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28837183/keratitis-in-association-with-herpes-zoster-and-varicella-vaccines
#20
A P Grillo, F W Fraunfelder
The objective of this review was to collect reports of keratitis in association with herpes zoster virus (HZV) or varicella zoster virus (VZV) vaccines. HZV vaccination is intended for at-risk adult populations and VZV vaccination is intended for all pediatric patients. We reviewed the literature and reports of keratitis in association with herpes zoster or varicella vaccine from the National Registry of Drug-Induced Ocular Side Effects and the World Health Organization. Twenty-four cases of unilateral keratitis in association with VZV vaccines were collected from the adverse reaction databases and literature...
July 2017: Drugs of Today
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