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https://www.readbyqxmd.com/read/28528079/the-lateral-habenula-and-the-serotonergic-system
#1
REVIEW
Martin Metzger, Debora Bueno, Leandro B Lima
The habenula (Hb) is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). After decades of relative neglect, interest in the Hb resurged when it was demonstrated that LHb neurons play a key role in encoding disappointments and expectation of punishments. Consistent with such a role, the LHb has been implicated in a broad array of functions and pathologic conditions, notably in mechanisms of stress and pain, as well as in the pathophysiology of mood disorders...
May 17, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28527717/inhibition-of-the-lateral-habenular-camk%C3%A2-abolishes-naloxone-precipitated-conditioned-place-aversion-in-morphine-dependent-mice
#2
Jing Wang, Min Li, Ping Wang, Yunhong Zha, Zhi He, Zicheng Li
Addictive substances mediate positive and negative states promoting compulsive drug use. However, substrates for aversive effects of drugs are not fully understood. We found that inactivation of the lateral habenula (LHb) by microinjection of tetrodotoxin (TTX) abolished naloxone-precipitated conditioned place aversion (CPA) in morphine-dependent mice. We also found that lateral habenular administration of KN-62, a specific inhibitor for calcium/calmodulin dependent protein kinase II (CaMKII), abolished naloxone-precipitated CPA in morphine-dependent mice...
May 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28507317/elevation-of-p11-in-lateral-habenula-mediates-depression-like-behavior
#3
J-S Seo, P Zhong, A Liu, Z Yan, P Greengard
The lateral habenula (LHb) is a key brain region involved in the pathophysiology of depression. It is activated by stimuli associated with negative experiences and is involved in encoding aversive signals. Hyperactivity of LHb is found in both rodent models of depression and human patients with depression. However, little is known about the underlying molecular mechanisms. Here we show that in LHb neurons, p11, a multifunctional protein implicated in depression, is significantly upregulated by chronic restraint stress...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28499809/an-emerging-role-for-the-lateral-habenula-in-aggressive-behavior
#4
REVIEW
Meghan Flanigan, Hossein Aleyasin, Aki Takahashi, Sam A Golden, Scott J Russo
Inter-male aggression is an essential component of social behavior in organisms from insects to humans. However, when expressed inappropriately, aggression poses significant threats to the mental and physical health of both the aggressor and the target. Inappropriate aggression is a common feature of numerous neuropsychiatric disorders in humans and has been hypothesized to result from the atypical activation of reward circuitry in response to social targets. The lateral habenula (LHb) has recently been identified as a major node of the classical reward circuitry and inhibits the release of dopamine from the midbrain to signal negative valence...
May 9, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28490656/role-of-habenula-and-amygdala-dysfunction-in-parkinson-disease-patients-with-punding
#5
Vladana Markovic, Federica Agosta, Elisa Canu, Alberto Inuggi, Igor Petrovic, Iva Stankovic, Francesca Imperiale, Tanja Stojkovic, Vladimir S Kostic, Massimo Filippi
OBJECTIVE: To assess whether a functional dysregulation of the habenula and amygdala, as modulators of the reward brain circuit, contributes to Parkinson disease (PD) punding. METHODS: Structural and resting-state functional MRI were obtained from 22 patients with PD punding, 30 patients with PD without any impulsive-compulsive behavior (ICB) matched for disease stage and duration, motor impairment, and cognitive status, and 30 healthy controls. Resting-state functional connectivity of the habenula and amygdala bilaterally was assessed using a seed-based approach...
May 10, 2017: Neurology
https://www.readbyqxmd.com/read/28474551/role-of-dopamine-signaling-in-drug-addiction
#6
Wan Chen, Zhihuan Nong, Yaoxuan Li, Jianping Huang, Chunxia Chen, Luying Huang
Addiction is a chronic, relapsing disease of the brain that includes drug-induced compulsive seeking behavior and consumption of drugs. Dopamine (DA) is considered to be critical in drug addiction due to reward mechanisms in the midbrain. In this article, we review the major animal models in addictive drug experiments in vivo and in vitro. We discuss the relevance of the structure and pharmacological function of DA receptors. To improve the understanding of the role of DA receptors in reward pathways, specific brain regions, including the Ventral tegmental area, Nucleus accumbens, Prefrontal cortex, and Habenula, are highlighted...
May 3, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28473012/circuits-regulating-pleasure-and-happiness-evolution-and-role-in-mental-disorders
#7
Anton J M Loonen, Svetlana A Ivanova
Taking the evolutionary development of the forebrain as a starting point, the authors developed a biological framework for the subcortical regulation of human emotional behaviour which may offer an explanation for the pathogenesis of the principle symptoms of mental disorders. Appetitive-searching (reward-seeking) and distress-avoiding (misery-fleeing) behaviour are essential for all free-moving animals to stay alive and to have offspring. Even the oldest ocean-dwelling animal creatures, living about 560 million years ago and human ancestors, must therefore have been capable of generating these behaviours...
May 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28442765/the-gpr139-reference-agonists-1a-and-7c-and-tryptophan-and-phenylalanine-share-a-common-binding-site
#8
Anne Cathrine Nøhr, Willem Jespers, Mohamed A Shehata, Leonard Floryan, Vignir Isberg, Kirsten Bayer Andersen, Johan Åqvist, Hugo Gutiérrez-de-Terán, Hans Bräuner-Osborne, David E Gloriam
GPR139 is an orphan G protein-coupled receptor expressed in the brain, in particular in the habenula, hypothalamus and striatum. It has therefore been suggested that GPR139 is a possible target for metabolic disorders and Parkinson's disease. Several surrogate agonist series have been published for GPR139. Two series published by Shi et al. and Dvorak et al. included agonists 1a and 7c respectively, with potencies in the ten-nanomolar range. Furthermore, Isberg et al. and Liu et al. have previously shown that tryptophan (Trp) and phenylalanine (Phe) can activate GPR139 in the hundred-micromolar range...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432009/the-lateral-hypothalamus-to-lateral-habenula-projection-but-not-the-ventral-pallidum-to-lateral-habenula-projection-regulates-voluntary-ethanol-consumption
#9
Chandni Sheth, Teri M Furlong, Kristen A Keefe, Sharif A Taha
The lateral habenula (LHb) is an epithalamic brain region implicated in aversive processing via negative modulation of midbrain dopamine (DA) and serotonin (5-HT) systems. Given the role of the LHb in inhibiting DA and 5-HT systems, it is thought to be involved in various psychiatric pathologies, including drug addiction. In support, it has been shown that LHb plays a critical role in cocaine- and ethanol-related behaviors, most likely by mediating drug-induced aversive conditioning. In our previous work, we showed that LHb lesions increased voluntary ethanol consumption and operant ethanol self-administration and blocked yohimbine-induced reinstatement of ethanol self-administration...
April 19, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28423013/mapping-the-co-localization-of-the-circadian-proteins-per2-and-bmal1-with-enkephalin-and-substance-p-throughout-the-rodent-forebrain
#10
Ariana Frederick, Jory Goldsmith, Nuria de Zavalia, Shimon Amir
Despite rhythmic expression of clock genes being found throughout the central nervous system, very little is known about their function outside of the suprachiasmatic nucleus. Determining the pattern of clock gene expression across neuronal subpopulations is a key step in understanding their regulation and how they may influence the functions of various brain structures. Using immunofluorescence and confocal microscopy, we quantified the co-expression of the clock proteins BMAL1 and PER2 with two neuropeptides, Substance P (SubP) and Enkephalin (Enk), expressed in distinct neuronal populations throughout the forebrain...
2017: PloS One
https://www.readbyqxmd.com/read/28420875/down-regulation-of-cholinergic-signaling-in-the-habenula-induces-anhedonia-like-behavior
#11
Seungrie Han, Soo Hyun Yang, Jin Yong Kim, Seojung Mo, Esther Yang, Ki Myung Song, Byung-Joo Ham, Naguib Mechawar, Gustavo Turecki, Hyun Woo Lee, Hyun Kim
Dysfunction of cholinergic signaling in the brain has long been believed to be associated with depressive disorders. However, the functional impact of habenular cholinergic signaling on the specified depressive behaviors is not well understood. Here, we demonstrated that the expression levels of cholinergic signaling genes (CHAT, VACHT, CHT, CHRNA3, CHRNB3 and CHRNB4) were down-regulated in a chronic restraint stress (CRS) rat model of depression, in which rats display depression-like behaviors such as anhedonia and mood despair...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28411158/intrinsic-membrane-properties-and-cholinergic-modulation-of-mouse-basal-forebrain-glutamatergic-neurons-in-vitro
#12
Chun Yang, James T McKenna, Ritchie E Brown
The basal forebrain (BF) controls sleep-wake cycles, attention and reward processing. Compared to cholinergic and GABAergic neurons, BF glutamatergic neurons are less well understood, due to difficulties in identification. Here, we use vesicular glutamate transporter 2 (vGluT2)-tdTomato mice, expressing a red fluorescent protein (tdTomato) in the major group of BF glutamatergic neurons (vGluT2+) to characterize their intrinsic electrical properties and cholinergic modulation. Whole-cell, patch-clamp recordings were made from vGluT2+ neurons in coronal BF slices...
June 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28387937/specific-connections-of-the-interpeduncular-subnuclei-reveal-distinct-components-of-the-habenulopeduncular-pathway
#13
Lely A Quina, Julie Harris, Hongkui Zeng, Eric E Turner
The habenulopeduncular pathway consists of the medial habenula (MHb), its output tract, the fasciculus retroflexus, and its principal target, the interpeduncular nucleus (IP). Several IP subnuclei have been described, but their specific projections and relationship to habenula inputs are not well understood. Here we have used viral, transgenic, and conventional anterograde and retrograde tract-tracing methods to better define the relationship between the dorsal and ventral MHb, the IP, and the secondary efferent targets of this system...
April 7, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28387223/ethanol-withdrawal-drives-anxiety-related-behaviors-by-reducing-m-type-potassium-channel-activity-in-the-lateral-habenula
#14
Seungwoo Kang, Jing Li, Wanhong Zuo, Rao Fu, Danielle Gregor, Kresimir Krnjevic, Alex Bekker, Jiang-Hong Ye
Alcohol use disorders (AUDs) and anxiety disorders (ADs) are often seen concurrently, but their underlying cellular basis is unclear. For unclear reasons, the lateral habenula (LHb), a key brain region involved in the pathophysiology of ADs, becomes hyperactive after ethanol withdrawal. M-type K(+) channels (M-channels), important regulators of neuronal activity, are abundant in the LHb, yet little is known about their role in AUDs and associated ADs. We report here that in rats at 24 h withdrawal from systemic ethanol administration (either by intraperitoneal injection, 2 g/kg, twice/day, for 7 days; or intermittent drinking 20% ethanol in a two-bottle free choice protocol for 8 weeks), the basal firing rate and the excitability of LHb neurons in brain slices was higher, whereas the amplitude of medium afterhyperpolarization and M-type K(+) currents were smaller, when compared to ethanol naïve rats...
April 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28384468/genetically-distinct-parallel-pathways-in-the-entopeduncular-nucleus-for-limbic-and-sensorimotor-output-of-the-basal-ganglia
#15
Michael L Wallace, Arpiar Saunders, Kee Wui Huang, Adrienne C Philson, Melissa Goldman, Evan Z Macosko, Steven A McCarroll, Bernardo L Sabatini
The basal ganglia (BG) integrate inputs from diverse sensorimotor, limbic, and associative regions to guide action-selection and goal-directed behaviors. The entopeduncular nucleus (EP) is a major BG output nucleus and has been suggested to channel signals from distinct BG nuclei to target regions involved in diverse functions. Here we use single-cell transcriptional and molecular analyses to demonstrate that the EP contains at least three classes of projection neurons-glutamate/GABA co-releasing somatostatin neurons, glutamatergic parvalbumin neurons, and GABAergic parvalbumin neurons...
April 5, 2017: Neuron
https://www.readbyqxmd.com/read/28382659/increased-firing-of-lateral-habenula-neurons-mediates-ethanol-aversion-potential-implications-for-substance-use-disorders
#16
Gabor Egervari, Tanni Rahman
No abstract text is available yet for this article.
April 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28340505/afferent-and-efferent-connections-of-the-interpeduncular-nucleus-with-special-reference-to-circuits-involving-the-habenula-and-raphe-nuclei
#17
Leandro B Lima, Debora Bueno, Fernanda Leite, Stefani Souza, Luciano Gonçalves, Isadora C Furigo, Jose Donato, Martin Metzger
The habenula is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). Recently, MHb together with its primary target, the interpeduncular nucleus (IP), have been identified as major players in mediating the aversive effects of nicotine. However, structures downstream of the MHb-IP axis, including the median (MnR) and caudal dorsal raphe nucleus (DRC), may contribute to the behavioral effects of nicotine. The afferent and efferent connections of the IP have hitherto not been systematically investigated with sensitive tracers...
March 24, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28334072/the-lateral-habenula-as-a-relay-of-cortical-information-to-process-working-memory
#18
Victor Mathis, Alexandra Barbelivien, Monique Majchrzak, Chantal Mathis, Jean-Christophe Cassel, Lucas Lecourtier
Working memory is a cognitive ability allowing the temporary storage of information to solve problems or adjust behavior. While working memory is known to mainly depend on the medial prefrontal cortex (mPFC), very few is known about how cortical information are relayed subcortically. By its connectivity, the lateral habenula (lHb) might act as a subcortical relay for cortical information. Indeed, the lHb receives inputs from several mPFC subregions, and recent findings suggest a role for the lHb in online processing of spatial information, a fundamental aspect of working memory...
October 13, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/28324234/damage-induced-alarm-cues-influence-lateralized-behaviour-but-not-the-relationship-between-behavioural-and-habenular-asymmetry-in-convict-cichlids-amatitlania-nigrofasciata
#19
Michele K Moscicki, Peter L Hurd
Cerebral lateralization, the partitioning of functions into a certain hemisphere of the brain, is ubiquitous among vertebrates. Evidence suggests that the cognitive processing of a stimulus is performed with a specific hemisphere depending in part upon the emotional valence of the stimulus (i.e. whether it is appetitive or aversive). Recent work has implicated a predominance of right-hemisphere processing for aversive stimuli. In fish with laterally placed eyes, the preference to view an object with a specific eye has been used as a proxy for assessing cerebral lateralization...
March 21, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28270756/role-of-the-lateral-habenula-in-pain-associated-depression
#20
Yanhui Li, Yumeng Wang, Chengluan Xuan, Yang Li, Lianhua Piao, Jicheng Li, Hua Zhao
Patients with chronic pain have significantly higher incidences of depression and anxiety than the average person. However, the mechanism underlying this link has not been elucidated in terms of how chronic pain causes significant mood changes and further develops into severe anxiety or depression. The serotonergic system in the raphe nuclei is an important component in both pain processing and the pathogenesis of depression. Since the lateral habenular nucleus (LHb) controls the raphe nuclei, it may participate in the regulation of pain-associated depression...
2017: Frontiers in Behavioral Neuroscience
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