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Enza Lacivita, Madia Letizia Stama, Jun Maeda, Masayuki Fujinaga, Akiko Hatori, Ming-Rong Zhang, Nicola A Colabufo, Roberto Perrone, Makoto Higuchi, Tetsuya Suhara, Marcello Leopoldo
Here, we describe the very first attempt to visualize in vivo formyl peptide receptors (FPRs) in mouse brain by positron emission tomography (PET). FPRs are expressed in microglial cells where they mediate chemotactic activity of β-amyloid peptide in Alzheimer disease and, thus, are involved in neuroinflammatory processes. To this purpose, we have selected (2S)-3-(1H-Indol-3-yl)-2-{[(4-methoxyphenyl)carbamoyl]amino}-N-{[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl}propanamide ((S)-1), that we have previously identified as a potent non-peptidic FPR agonist...
July 2016: Chemistry & Biodiversity
Ali Taylan, Oguz Gurler, Burak Toprak, Ali Riza Sisman, Hulya Yalcin, Ayfer Colak, Ismail Sari
Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterised by periodic inflammatory attacks. We investigated changes in monocyte-granulocyte derived S10012A and chitotriosidase in both the attack and silent period of FMF for better estimation of inflammation. Endogenous resolvin was determined for utility to restrict inflammation. This study included 29 FMF patients (15 M/14 F) and 30 healthy controls (15 M/15 F). Serum levels of highly sensitive C-reactive protein, serum amiloid A (SAA), S100A12, chitotriosidase, and resolvin D1 were measured...
September 2015: Journal of Korean Medical Science
Ozturk Ozdemir, Mansur Kayatas, Selma Cetinkaya, Malik Ejder Yildirim, Fatma Silan, Hande Kucuk Kurtulgan, Binnur Koksal, Mine Urfali, Ferhan Candan
BACKGROUND AND AIM: There is an increased mortality risk in long-term hemodialysis patients of renal failure due to the chronic inflammation. The relationship between the chronic renal failure (CRF) and the role of familial genetic markers remains incompletely understood. In the current study, it was aimed to find out the prevalence of common MEFV gene mutations and BcII polymorphism in serum amyloid A1 (SAA1) gene in chronic renal patients (CRF) who require long-term hemodialysis. METHOD: Current cohort includes 242 CRF patients and 245 healthy individuals from the same population...
March 2015: Renal Failure
M Sit, O Catal, G Aktas, E E Yilmaz, M Tosun, H Savli
BACKGROUND: The diagnosis of acute appendicitis is based on medical history and physical examination. Serum (S) amiloid A (AA) levels are elevated in many inflammatory conditions. Omentin is a recently discovered adipokine showing decreased levels associated with inflammatory conditions. We aimed to measure SAA and omentin levels in patients with acute appendicitis. MATERIALS AND METHODS: 36 patients with a diagnosis of acute appendicitis and 30 healthy subjects were enrolled to this research study...
2014: La Clinica Terapeutica
Jesús A Mosquera
The receptor for advanced glycation end products (RAGE) is a transmembrane protein on the cellular surface that recognizes tridimensional molecules, instead of aminoacid sequences, making this molecule capable of interacting with diverse ligands. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including diabetes, atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases...
June 2010: Investigación Clínica
Consuelo Funes, Faustino Garcia-Candel, Maria Juliana Majado, Consuelo González-García, Agueda Bas, Eduardo Salido, Jose M Moraleda, Alfonso Morales
Splenic rupture (SR) is a rare adverse event observed in patients treated with G-CSF as a peripheral hematopoietic stem cell (PHSC) mobilizing agent, mostly in myeloma multiple and amiloidosis; to date, to our knowledge, it has not been previously described in plasma-cell leukemia (PCL). We report a case of a woman with PCL, who presented a SR after PHSC mobilization with Cyclophosphamide+G-CSF. The spleen removed showed hematopoietic foci and amiloid material. In the course of a second mobilization, 2 months after, the patient died from sepsis...
2010: Journal of Clinical Apheresis
Demet Etit, Mehmet Ali Uyaroglu, Nezahat Erdogan
Odontogenic tumors constitute a group of heterogeneous disease derived from epithelial, mesenchymal and/or ectomesenchymal elements. Ameloblastoma is the best known and the most frequent form of odontogenic tumors. Calcifying epithelial odontogenic tumor (CEOT), known as Pindborg tumor, is locally invasive lesion which has a characteristic amiloid deposition. Here a case of a peripheral ameloblastoma associated with CEOT is presented with clinical and morphological features.
January 2010: Indian Journal of Pathology & Microbiology
María Celeste Leal, Agata Fernandez Gamba, Laura Morelli, Eduardo M Castaño
The global increase in life expectancy turns Alzheimer's disease (AD) into a growing problem. One of the distinctive features of AD is the excessive accumulation of amyloid-b (Ab) peptide in the brain. In recent years, a concept that has gained strength is that degradation of Ab by proteases in situ is an important mechanism that prevents cerebral peptide accumulation. Biochemical and genetic data have shown that insulin-degrading enzyme (IDE) participates in Ab and insulin homeostasis. IDE expression and activity are significantly decreased in AD brains compared to age-matched controls...
2009: Medicina
Teresa Mairal, Joan Nieto, Marta Pinto, Maria Rosário Almeida, Luis Gales, Alfredo Ballesteros, José Barluenga, Juan J Pérez, Jesús T Vázquez, Nuria B Centeno, Maria Joao Saraiva, Ana M Damas, Antoni Planas, Gemma Arsequell, Gregorio Valencia
The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one of the 20 or so known amyloid diseases. TTR self assembles as a homotetramer leaving a central hydrophobic channel with two symmetrical binding sites. The aggregation pathway of TTR into amiloid fibrils is not yet well characterized but in vitro binding of thyroid hormones and other small organic molecules to TTR binding channel results in tetramer stabilization which prevents amyloid formation in an extent which is proportional to the binding constant...
2009: PloS One
M Romano, R Faggioni, M Sironi, S Sacco, B Echtenacher, E Di Santo, M Salmona, P Ghezzi
We used the mouse air pouch model of inflammation to study the interaction between cytokines, prostaglandin E(2) (PGE(2)) and cell migration during the various phases of acute local inflammation induced by carrageenan. In serum, the levels of interleukin 1 (IL-1), interleukin 6 (IL-6), tumour necrosis factor (TNF), serum amiloid-A (SAA) and Fe(++) were never different from controls, indicating that no systemic inflammatory changes were induced. Locally the exudate volume and the number of leukocytes recruited into the pouch increased progressively until 7 days after carrageenan...
1997: Mediators of Inflammation
Maurizio Benucci, Federica Maniscalchi, Mariangela Manfredi
Amyloidosis refers to the extracellular deposition of proteinaceous insoluble fibrils in various tissues, resulting in organ compromise. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, in which AA fibrils, derived from the acute phase protein, serum amyloid-A (SAA). We evaluated the prevalence of AA with lip biopsy on 106 rheumatoid arthritis patients (according to 1988 ARA criteria), asymptomaticwith regard to amyloidosis (90 females, 16 males). On histological salivary gland samples we evaluated the presence of AA by an immunohistochemical method [Anti Human Amiloid clone MC-1 (DAKO, Italy)]...
January 2007: Recenti Progressi in Medicina
F Contégal, S Bidot, C Thauvin, L Lévèque, P Soichot, P Gras, T Moreau, M Giroud
INTRODUCTION: Finnish amyloid variety is a rare familial amiloidosis polyneuropathy essentially observed in Finland. It concerns about six hundred people in the world in which five hundred reside in Finland. OBSERVATION: We report a case of a 58-year-old French woman with a 10-year history of lattice cornea dystrophy. She consulted in January 2004 for impaired swallowing, facial paralysis principally of the right superior territory and symptoms of arthritis which had developed a few months earlier...
October 2006: Revue Neurologique
Francisco José Vera Sempere, María Jose Artes Martínez, Beatriz Vera Sirera, Jaime Bonet Marco
Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic lesion that affects young patients, with female predominance, mainly in second decade, showing a radiolucent unilocular image associated with an unerupted tooth, usually a canine. In spite of previous and confusing denominations, such as adenoameloblastoma or adenomatoid ameloblastic tumor, AOT is a benign tumor with a very low rate of recurrence, that show a peculiar morphological picture (basaloid appearance with glandular-like structures, calcifying areas, and amiloid-like material) that allow its histopathological recognition...
July 2006: Medicina Oral, Patología Oral y Cirugía Bucal
L V Kozlovskaia, V V Rameev, E P Proskurneva, V I Osipenko, I A Sarkisova, A A Onoprienko
Here is an observation data on systemic AL-amiloidosis with primary lesion of lungs and vessels (a false hemorrhagic syndrome, ischemic insult in the region of middle cerebral artery). At the same time lesions of kidneys and heart became of minor significance. Amiloid lesion of lungs was characterized by unusual combination of symptoms: a galloping hydrothorax, a vast focus in the consolidation of pulmonary tissue with focuses of calcification, relapsing pneumothorax.
2002: Klinicheskaia Meditsina
D C Anthony, P Hughes, V H Perry
INTRODUCTION: At what stage in the pathogenesis of multiple sclerosis (MS) does the damage to axons occur, and why should there be any axon loss at all in what is thought to be principally an axon sparing demyelinating disease? A recently described new technique for investigating axon damage depends for its ability on the immunoreactivity of amiloid precursor protein (APP), which has been shown to be more sensitive than silver stains for detecting damaged axons. DEVELOPMENT: We used APP immunoreactivity as a method to investigate whether axon damage occurs in acute MS lesions...
June 16, 2000: Revista de Neurologia
L Gargiulo, M Bermejo, A Liras
INTRODUCTION: Alzheimer's disease is characterized by a general and progressive dementia and by the presence of beta-amiloide deposits. OBJECTIVE: The levels of neuronal nitric oxide synthase (NOS) and protein kinase C (PKC), and the relationship between these proteins, the free-radical theory and the high level of beta-amiloide in Alzheimer's disease, have been studied. MATERIAL AND METHODS: The study has been performed in samples of Alzheimer's disease (superior, medial and inferior regions of temporalis gyrus) from control individuals and patients...
February 16, 2000: Revista de Neurologia
E Monteiro, R Perdigoto, A L Furtado
Familiar Amyloid Polyneuropathy (FAP), an autosomal dominant inherited multisystemic disorder was first observed by Corino de Andrade, a Portuguese neurologist, in 1939. This disease of Portuguese origin was probably spread by fishermen, mainly to Sweden and Japan. It is characterized by a progressive peripheral polyneuropathy and autonomic neuropathy (erectile sexual disfunction, gastrointestinal disfunction, bladder dysfunction and cardio vascular disease) and malnutrition. There are neural and systemic amiloid deposits...
September 1998: Hepato-gastroenterology
S Berger, M Bleich, W Schmid, T J Cole, J Peters, H Watanabe, W Kriz, R Warth, R Greger, G Schütz
Mineralocorticoid receptor (MR)-deficient mice were generated by gene targeting. These animals had a normal prenatal development. During the first week of life, MR-deficient (-/-) mice developed symptoms of pseudohypoaldosteronism. They finally lost weight and eventually died at around day 10 after birth from dehydration by renal sodium and water loss. At day 8, -/- mice showed hyperkalemia, hyponatremia, and a strong increase in renin, angiotensin II, and aldosterone plasma concentrations. Methods were established to measure renal clearance and colonic transepithelial Na+ reabsorption in 8-day-old mice in vivo...
August 4, 1998: Proceedings of the National Academy of Sciences of the United States of America
E Nardelli, F Buonanno, L Onnis, N Rizzuto
A case of progressive myoclonic epilepsy (P.M.E.) is described. The clinical picture consisted of epileptic seizures, myoclonus and slight mental deterioration associated with a severe progressive cerebellar syndrome. The disease had a course of almost 20 years. Histological studies of the C.N.S. showed severe loss of Purkinje cells, sligth regressive changes in both dentate and olivary nuclei, nerve cells atrophy of anterior horn motoneurons, degeneration of Goll's and Burdach's spino-olivary and anterior spino-cerebellar tracts...
July 1975: Rivista di Patologia Nervosa e Mentale
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