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https://www.readbyqxmd.com/read/29235438/acoustic-stimulation-can-induce-a-selective-neural-network-response-mediated-by-piezoelectric-nanoparticles
#1
Camilo Andres Rojas Cifuentes, Mariateresa Tedesco, Paolo Massobrio, Attilio Marino, Gianni Ciofani, Sergio Martinoia, Roberto Raiteri
OBJECTIVE: We aim at developing novel non-invasive or minimally invasive methods for neural stimulation to be applied in the study and treatment of brain (dys)functions and neurological disorders. APPROACH: We investigate the electrophysiological response of in vitro neuronal networks when subjected to low intensity pulsed acoustic stimulation mediated by piezoelectric nanoparticles adsorbed on the neuronal membrane. MAIN RESULTS: We show that the presence of piezoelectric barium titanate nanoparticles induces, in a reproducible way, an increase in the network activity when excited by stationary ultrasound waves in the MHz regime...
December 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29229974/ensemble-modeling-approach-targeting-heterogeneous-rna-seq-data-application-to-melanoma-pseudogenes
#2
Enrico Capobianco, Camilo Valdes, Samanta Sarti, Zhijie Jiang, Laura Poliseno, Nicolas F Tsinoremas
We studied the transcriptome landscape of skin cutaneous melanoma (SKCM) using 103 primary tumor samples from TCGA, and measured the expression levels of both protein coding genes and non-coding RNAs (ncRNAs). In particular, we emphasized pseudogenes potentially relevant to this cancer. While cataloguing the profiles based on the known biotypes, all the employed RNA-Seq methods generated just a small consensus of significant biotypes. We thus designed an approach to reconcile the profiles from all methods following a simple strategy: we selected genes that were confirmed as differentially expressed by the ensemble predictions obtained in a regression model...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229697/temporal-proteomics-of-inducible-rnai-lines-of-clp-protease-subunits-identifies-putative-protease-substrates
#3
Juan Camilo Moreno Beltran, Silvia Martinez-Jaime, Joram Schwartzmann, Daniel Karcher, Michael Tillich, Alexander Graf, Ralph Bock
The Clp protease in the chloroplasts of plant cells is a large complex composed of at least 13 nucleus-encoded subunits and one plastid-encoded subunit which are arranged in several ring-like structures. The proteolytic P-ring and the structurally similar R-ring form the core complex that contains the proteolytic chamber. Chaperones of the HSP100 family help with substrate unfolding and additional accessory proteins are believed to assist with Clp complex assembly and/or promote complex stability. Although structure and function of the Clp protease have been studied in great detail in both bacteria and chloroplasts, the identification of bona fide protease substrates has been very challenging...
December 11, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29226598/the-time-has-come-for-dimensional-personality-disorder-diagnosis
#4
Christopher J Hopwood, Roman Kotov, Robert F Krueger, David Watson, Thomas A Widiger, Robert R Althoff, Emily B Ansell, Bo Bach, R Michael Bagby, Mark A Blais, Marina A Bornovalova, Michael Chmielewski, David C Cicero, Christopher Conway, Barbara De Clerq, Filip De Fruyt, Anna R Docherty, Nicholas R Eaton, John F Edens, Miriam K Forbes, Kelsie T Forbush, Michael P Hengartner, Masha Y Ivanova, Daniel Leising, W John Livesley, Mark R Lukowitsky, Donald R Lynam, Kristian E Markon, Joshua D Miller, Leslie C Morey, Stephanie N Mullins-Sweatt, J Hans Ormel, Christopher J Patrick, Aaron L Pincus, Camilo Ruggero, Douglas B Samuel, Martin Sellbom, Tim Slade, Jennifer L Tackett, Katherine M Thomas, Timothy J Trull, David D Vachon, Irwin D Waldman, Monika A Waszczuk, Mark H Waugh, Aidan G C Wright, Mathew M Yalch, David H Zald, Johannes Zimmermann
No abstract text is available yet for this article.
December 11, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/29226456/cigarette-smoke-extract-induces-oral-squamous-cell-carcinoma-cell-invasion-in-a-receptor-for-advanced-glycation-end-products-dependent-manner
#5
Steven Chapman, Madison Mick, Parker Hall, Camilo Mejia, Stephanie Sue, Bihishta Abdul Wase, Margaret A Nguyen, Evan C Whisenant, Shalene H Wilcox, Duane Winden, Paul R Reynolds, Juan A Arroyo
Oral squamous cell carcinoma (OSCC) affects approximately 30,000 people and is associated with tobacco use. Little is known about the mechanistic effects of second-hand smoke in the development of OSSC. The receptor for advanced glycation end-products (RAGE) is a surface receptor that is upregulated by second-hand smoke and inhibited by semi-synthetic glycosaminoglycan ethers (SAGEs). Our objective was to determine the role of RAGE during cigarette smoke extract-induced cellular responses and to use SAGEs as a modulating factor of Ca9-22 OSCC cell invasion...
December 11, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29225652/repair-of-iatrogenic-furcal-perforation-with-mineral-trioxide-aggregate-a-seven-year-follow-up
#6
Jardel Camilo do Carmo Monteiro, Mateus Rodrigues Tonetto, Matheus Coêlho Bandeca, Alvaro Henrique Borges, José Cláudio Martins Segalla, Keren Cristina Fagundes Jordão-Basso, Cristian Fernando Sanchez-Puetate, Milton Carlos Kuga
Teeth with furcal perforation present difficult resolution and dubious prognosis. Several materials have been proposed and calcium silicate-based cements such as mineral trioxide aggregate (MTA) are the most recommended. However, its long-term clinical behavior still remains poorly understood. The present study reports a clinical case of furcal perforation repair using Angelus MTA, with a 7-year follow-up. Patient sought treatment 2 months after iatrogenic accident. First lower right molar presented clinical signs such as fistula and bone loss between mesial and distal roots...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29223404/computer-assisted-total-knee-arthroplasty-is-there-a-difference-between-image-based-and-imageless-techniques
#7
Reza M Tabatabaee, Mohammad R Rasouli, Mitchell G Maltenfort, Robert Fuino, Camilo Restrepo, Ali Oliashirazi
BACKGROUND: Image-based and imageless computer-assisted total knee arthroplasty (CATKA) has become increasingly popular. This study aims to compare outcomes, including perioperative complications and transfusion rate, between CATKA and conventional total knee arthroplasty (TKA), as well as between image-based and imageless CATKA. METHODS: Using the 9th revision of the International Classification of Diseases codes, we queried the Nationwide Inpatient Sample database from 2005 to 2011 to identify unilateral conventional TKA, image-based, and imageless CATKAs as well as in-hospital complications and transfusion rates...
November 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29223120/de-icing-salt-contamination-reduces-urban-tree-performance-in-structural-soil-cells
#8
Camilo Ordóñez-Barona, Vadim Sabetski, Andrew A Millward, James Steenberg
Salts used for de-icing roads and sidewalks in northern climates can have a significant impact on water quality and vegetation. Sub-surface engineering systems, such as structural soil cells, can regulate water runoff and pollutants, and provide the necessary soil volume and irrigation to grow trees. However, the ability of such systems to manage de-icing salt contamination, and the impact of this contamination on the trees growing in them, have not been evaluated. We report on an field investigation of de-icing salt contamination in structural cells in two street-revitalization projects in Toronto, Canada, and the impact of this contamination on tree performance...
December 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29214196/structural-and-biochemical-data-of-trichoderma-harzianum-gh1-%C3%AE-glucosidases
#9
Renata N Florindo, Valquiria P Souza, Hemily S Mutti, Lívia R Manzine Margarido, Cesar Camilo, Sandro R Marana, Igor Polikarpov, Alessandro S Nascimento
Here the statistics concerning X-ray data processing and structure refinement are given, together with the substrate preference analysis for ThBgl1 and ThBgl2. Finally, the analysis of the influence of temperature and pH on the activities of both enzymes are shown.
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29208910/author-correction-temperature-dependence-of-protein-water-interactions-in-a-gated-yeast-aquaporin
#10
Camilo Aponte-Santamaría, Gerhard Fischer, Petra Båth, Richard Neutze, Bert L de Groot
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207380/body-mass-index-and-olfactory-fossa-depth-in-patients-with-and-without-spontaneous-cerebrospinal-fluid-leaks
#11
Christopher J Ito, Camilo Reyes-Gelves, Clayton Perry, Stilianos E Kountakis
BACKGROUND/AIMS: Spontaneous cerebrospinal fluid (SCSF) leaks are associated with a high body mass index (BMI) and an expanded skull base. The purpose of this study is to determine if a correlation exists between BMI and olfactory fossa depth (OFD) in patients with SCSF leaks and those without. METHODS: This is a cross-sectional study evaluating the correlation between OFD and BMI in patients with and without SCSF leaks. OFD was measured on computed tomography obtained in temporal proximity to the BMI...
December 6, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29204794/thoracic-aortic-aneurysm-unlocking-the-silent-killer-secrets
#12
Ayman A Saeyeldin, Camilo A Velasquez, Syed Usman B Mahmood, Adam J Brownstein, Mohammad A Zafar, Bulat A Ziganshin, John A Elefteriades
Thoracic aortic aneurysm (TAA) is an increasingly recognized condition that is often diagnosed incidentally. This review discusses ten of the most relevant epidemiological and clinical secrets of this disease; (1) the difference in pathogenesis between ascending and descending TAAs. TAAs at these two sites act as different diseases, which is related to the different embryologic origins of the ascending and descending aorta. (2) The familial pattern and genetics of thoracic aneurysms. Syndromic TAAs only explain 5% of the pattern of inheritance...
December 4, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29203900/intracellular-immunization-against-hiv-infection-with-an-intracellular-antibody-that-mimics-hiv-integrase-binding-to-the-cellular-ledgf-protein
#13
Leyuan Bao, Clare Hannon, Abimael Cruz-Mignoni, Denis Ptchelkine, Mei-Yi Sun, Ami Miller, Wilawan Bunjobpol, Camilo E Quevedo, Mariliza Derveni, Jennifer Chambers, Alison Simmons, Simon E V Phillips, Terence H Rabbitts
Preventing the protein-protein interaction of the cellular chromatin binding protein Lens Epithelium-Derived Growth Factor (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible strategy for anti-viral treatment for AIDS. We have used Intracellular Antibody Capture technology to isolate a single VH antibody domain that binds to LEDGF. The crystal structure of the LEDGF-VH complex reveals that the single domain antibody mimics the effect of binding of HIV integrase to LEDGF which is crucial for HIV propagation...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29201465/a-reliable-and-reproducible-model-for-assessing-the-effect-of-different-concentrations-of-%C3%AE-solanine-on-rat-bone-marrow-mesenchymal-stem-cells
#14
Adriana Ordóñez-Vásquez, Lorenza Jaramillo-Gómez, Camilo Duran-Correa, Erandi Escamilla-García, Myriam Angélica De la Garza-Ramos, Fernando Suárez-Obando
Αlpha-solanine (α-solanine) is a glycoalkaloid present in potato (Solanum tuberosum). It has been of particular interest because of its toxicity and potential teratogenic effects that include abnormalities of the central nervous system, such as exencephaly, encephalocele, and anophthalmia. Various types of cell culture have been used as experimental models to determine the effect of α-solanine on cell physiology. The morphological changes in the mesenchymal stem cell upon exposure to α-solanine have not been established...
2017: Bone Marrow Research
https://www.readbyqxmd.com/read/29194804/the-use-of-ultrasonography-in-the-reproductive-evaluation-of-boars
#15
R O Pinho, B S Camilo, Dma Lima, Fac Villadiego, Jcm Vergara, H H Shiomi, R E Cardoso, P S Lopes, Sef Guimarães, J D Guimarães
The objective was to study the use of ultrasound as a complementary test in the breeding soundness evaluation in male pigs and study the pattern of echogenicity of the testicular parenchyma in boars of different racial groups. Twenty-six adult boars from four different racial groups were used, 10 from the Piau breed (group 1), four from the commercial and finishing group (group 2), six Pietrain breed (group 3) and six from the Duroc breed (group 4). All animals were evaluated for breeding soundness evaluation and the ultrasound examination of the testicles...
December 1, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29191474/chikungunya-related-erosive-arthritis-case-report-and-literature-review
#16
Francisco Castro-Domínguez, Tarek Carlos Salman-Monte, Fabiola Ojeda, Patricia Corzo, Irene Carrión-Barberá, Ivan Camilo Garcia-Duitama, Jordi Monfort
Chikungunya virus infection (CHIKV) is associated with joint involvement in half of the cases. This can lead to erosive arthritis which, given the high intervariability of clinical and serological presentations, and the probable role of genetic conditioning in the severity and chronification of the condition, represents a great diagnostic and therapeutic challenge. There is an important lack of scientific evidence that would enable us to characterize the variability of the patient and choose the most appropriate approach...
November 27, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29189567/transfusion-of-red-blood-cells-stored-more-than-28-days-is-associated-with-increased-morbidity-following-spine-surgery
#17
Taylor E Purvis, C Rory Goodwin, Camilo A Molina, Steven M Frank, Daniel M Sciubba
STUDY DESIGN: Retrospective study. OBJECTIVE: To describe the association between storage duration of packed red blood cells (PRBCs) and perioperative adverse events in patients undergoing spine surgery at a tertiary care center. SUMMARY OF BACKGROUND DATA: Despite retrospective studies that have shown that longer PRBC storage duration worsens patient outcomes, randomized clinical trials have found no difference in outcomes. However, no studies have examined the impact of giving the oldest blood (28 days-old or more) on morbidity within spine surgery...
November 17, 2017: Spine
https://www.readbyqxmd.com/read/29185164/extracellular-chromone-derivatives-in-cell-cultures-of-pimpinella-anisum-influence-of-elicitation-with-methyl-jasmonate-and-2%C3%AE-methyl-cyclodextrins
#18
Camilo Soto-Argel, Diego Hidalgo, Javier Palazon, Purificación Corchete
OBJECTIVES: To explore the potentiality of undifferentiated Pimpinella anisum L. cell cultures for the production of secondary metabolites by means of elicitation. RESULTS: Two chromone compounds were secreted to the medium of undifferentiated cultures of P. anisum: 4-methoxyfuro[3,2-g]chromen-7-one, known as bergapten, which is constitutive to anise, and 5-hydroxy-7-methoxy-2-methylchromen-4-one, the rare chromone eugenin, not yet described in P. anisum. Caffeoyl quinic acid species were also identified in the biomass...
November 28, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29184197/mixed-selectivity-morphs-population-codes-in-prefrontal-cortex
#19
Aishwarya Parthasarathy, Roger Herikstad, Jit Hon Bong, Felipe Salvador Medina, Camilo Libedinsky, Shih-Cheng Yen
The prefrontal cortex maintains working memory information in the presence of distracting stimuli. It has long been thought that sustained activity in individual neurons or groups of neurons was responsible for maintaining information in the form of a persistent, stable code. Here we show that, upon the presentation of a distractor, information in the lateral prefrontal cortex was reorganized into a different pattern of activity to create a morphed stable code without losing information. In contrast, the code in the frontal eye fields persisted across different delay periods but exhibited substantial instability and information loss after the presentation of a distractor...
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29179631/bulimic-symptomatology-among-male-collegiate-athletes-a-test-of-an-etiological-model
#20
Justine Chatterton, Trent A Petrie, Keke L Schuler, Camilo Ruggero
We tested Petrie and Greenleaf's psychosocial model in relation to male athletes' bulimic symptomatology. Through structural equation modeling, we cross-sectionally examined the direct and indirect effects of general and sport-specific appearance pressures, internalization, body satisfaction, drive for muscularity, negative affect, and dietary restraint on bulimic symptomatology. Participants were U.S. male collegiate athletes (N = 698; Mage = 19.87 years) representing 17 sports. With minor respecifications, the model had acceptable fit, and the psychosocial variables explained 48% of the bulimic symptomatology variance...
November 28, 2017: Journal of Sport & Exercise Psychology
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