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https://www.readbyqxmd.com/read/29348480/association-between-plasma-concentrations-of-branched-chain-amino-acids-and-adipokines-in-japanese-adults-without-diabetes
#1
Ryoko Katagiri, Atsushi Goto, Sanjeev Budhathoki, Taiki Yamaji, Hiroshi Yamamoto, Yumiko Kato, Motoki Iwasaki, Shoichiro Tsugane
Previous studies have consistently reported an association between circulating levels of branched-chain amino acids (BCAAs) or adipokines and insulin resistance; however, the association between BCAA and adipokine levels remains to be clarified. In this cross-sectional study involving 678 participants (435 men) without diabetes, plasma BCAA (valine, leucine, and isoleucine), adipokine (total and high molecular weight [HMW] adiponectin, leptin, and tumor necrosis factor-α [TNF-α]) concentrations, and an updated homeostasis model assessment of insulin resistance (HOMA2-IR) were measured...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321831/changes-in-smoking-prevalence-and-cessation-support-and-factors-associated-with-successful-smoking-cessation-in-swedish-patients-with-asthma-and-copd
#2
Marcus Stegberg, Mikael Hasselgren, Scott Montgomery, Karin Lisspers, Björn Ställberg, Christer Janson, Josefin Sundh
Introduction: Our aim was to investigate changes in smoking prevalence, smoking cessation support and factors associated with successful smoking cessation in patients with asthma and COPD. Methods: Questionnaires about available smoking cessation resources were completed by 54 primary health-care centers and 14 hospitals in central Sweden in 2005 and 2012. Patient data were collected using record reviews and patients questionnaires for two cohorts of randomly selected asthma and COPD patients in 2005 (n = 2306; with a follow up in 2012), and in 2014/2015 (n = 2620)...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29315968/cuffed-endotracheal-tubes-in-infants-less-than-3-kg-a-retrospective-cohort-study
#3
Rebecca E Thomas, Shripada C Rao, Corrado Minutillo, Bruce Hullett, Max K Bulsara
BACKGROUND: Cuffed endotracheal tubes are being increasingly used in infants; however, current evidence in the literature mostly includes infants ≥ 3-kg weight. AIMS: The aim of this observational study was to compare the short-term outcomes with the use of Microcuff® cuffed vs uncuffed endotracheal tubes in neonates < 3 kg. METHODS: We performed a retrospective cohort study in a single-centre, tertiary children's hospital neonatal intensive care unit...
January 9, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29279178/radiologic-discrepancies-in-children-with-special-healthcare-needs-in-a-pediatric-emergency-department
#4
Ara Festekjian, Karen Y Kwan, Todd P Chang, Hollie Lai, Margil Fahit, Danica B Liberman
BACKGROUND: After-hours radiologic interpretation by nonradiology attendings or resident radiologists introduces the risk of discrepancies. Clinical outcomes following radiologic discrepancies among pediatric emergency department (ED) patients are poorly described. In particular, children with special healthcare needs (CSHCN), have more opportunities for discrepancies and potential consequences than non- CSHCN. Our objective was to determine the rates and types of radiologic discrepancies, and to compare CSHCN to non-CSHCN...
December 21, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29189958/surgical-treatment-of-spinal-metastases-from-renal-cell-carcinoma-effects-of-preoperative-embolization-on-intraoperative-blood-loss
#5
Matthias Reitz, Klaus Christian Mende, Christopher Cramer, Theresa Krätzig, ZSuzsanna Nagy, Eik Vettorazzi, Sven Oliver Eicker, Marc Dreimann
The objective of this paper is analyzing the effects of preoperative embolization on intraoperative blood loss in spinal surgery for renal cell carcinoma (RCC) metastasis and identifying factors contributing to an increased blood loss in the surgical procedure. A retrospective analysis was performed in patients who were treated in for spinal metastasis from RCC between 2011 and 2016. Factors analyzed were reduction of tumor blush, timing of embolization, selective vs. superselective approach, surgical factors, and tumor volume and localization...
November 30, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29180125/clinical-and-microbiological-characteristics-of-the-infections-in-patients-treated-with-rituximab-for-autoimmune-and-or-malignant-hematological-disorders
#6
REVIEW
Jean-Jacques Tudesq, Guillaume Cartron, Sophie Rivière, David Morquin, Laura Iordache, Alfred Mahr, Valérie Martinez-Pourcher, Kada Klouche, Diane Cerutti, Alain Le Quellec, Philippe Guilpain
INTRODUCTION: Rituximab is commonly used for the treatment of hematological malignancies and autoimmune diseases. Despite a reputation for good tolerance, case-series and registries reported rituximab-related infections of variable severity including opportunistic infections. We aimed at describing the natural history of infectious events (IE) after treatment by rituximab providing clinical and microbiological features and outcome. PATIENTS AND METHODS: We retrospectively analyzed the medical records of patients treated with rituximab in an internal medicine department of a tertiary hospital between 2007 and 2015, and identified all iE after this therapy...
November 24, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29160159/reported-habitual-intake-of-breakfast-and-selected-foods-in-relation-to-overweight-status-among-seven-to-nine-year-old-swedish-children
#7
Bente B Nilsen, Agneta Yngve, Celia Monteagudo, Richard Tellström, Henrik Scander, Bo Werner
AIM: The aim of this study was to examine the reported frequency of breakfast intake and selected food and beverages in the investigated group of Swedish children in comparison with recommended intakes. Furthermore, the study analyses these food habits and some demographic and lifestyle factors in relation to overweight and obesity. METHODS: This cross-sectional study builds on data collected in 2008 and 2010. Measured anthropometric data and parent questionnaire data were collected...
August 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29157150/assessment-of-urinary-protein-composition-in-response-to-consecutive-days-of-wildland-firefighting
#8
Nobuo Yasuda, Brent C Ruby
The purpose of this study was to examine the pattern of urinary protein excretion induced by three consecutive days of wildland firefighting. Eighteen male active duty military personnel were served as the participants. All testing consisting of three consecutive days was conducted at a Northwestern USA fire camp. All participants consumed military-based foods containing 2620-2864 kcal/day. The work activity was evaluated with an accelerometer in association with body weight and hydration markers over the experimental period...
November 20, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29120285/women-s-satisfaction-and-perception-of-control-in-childbirth-in-three-arab-countries
#9
Tamar Kabakian-Khasholian, Hyam Bashour, Amina El-Nemer, Mayada Kharouf, Salah Sheikha, Nasser El Lakany, Rafik Barakat, Ohoud Elsheikh, Nadia Nameh, Rabih Chahine, Anayda Portela
Women's satisfaction and perceived control in childbirth are important attributes of the childbirth experience and quality of care indicators. This article presents findings from the pre-intervention phase of a multi-centre implementation study in Egypt, Lebanon and Syria, to introduce a labour companionship model in these countries. A sample of 2620 women giving birth in three public teaching hospitals from November 2014 to July 2015 in Beirut and Mansoura, and from November 2014 to April 2015 in Damascus were interviewed by trained field workers...
October 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29068678/efficient-and-accurate-born-oppenheimer-molecular-dynamics-for-large-molecular-systems
#10
Laurens D M Peters, Jörg Kussmann, Christian Ochsenfeld
An efficient scheme for the calculation of Born-Oppenheimer molecular dynamics (BOMD) simulations is introduced. It combines the corrected small basis set Hartree-Fock (HF-3c) method by Sure and Grimme [J. Comput. Chem. 2013, 43, 1672], extended Lagrangian BOMD (XL-BOMD) by Niklasson et al. [J. Chem. Phys. 2009, 130, 214109], and the calculation of the two electron integrals on graphics processing units (GPUs) [J. Chem. Phys. 2013, 138, 134114; J. Chem. Theory Comput. 2015, 11, 918]. To explore the parallel performance of our strong scaling implementation of the method, we present timings and extract, as its validation and first illustrative application, high-quality vibrational spectra from simulated trajectories of β-carotene, paclitaxel, and liquid water (up to 500 atoms)...
October 25, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29042306/cigarette-smoke-induces-mitochondrial-metabolic-reprogramming-in-lung-cells
#11
Hitendra S Solanki, Niraj Babu, Ankit Jain, Mohd Younis Bhat, Vinuth N Puttamallesh, Jayshree Advani, Remya Raja, Kiran K Mangalaparthi, Mahesh M Kumar, T S Keshava Prasad, Premendu Prakash Mathur, David Sidransky, Harsha Gowda, Aditi Chatterjee
Cellular transformation owing to cigarette smoking is due to chronic exposure and not acute. However, systematic studies to understand the molecular alterations in lung cells due to cigarette smoke are lacking. To understand these molecular alterations induced by chronic cigarette smoke exposure, we carried out tandem mass tag (TMT) based temporal proteomic profiling of lung cells exposed to cigarette smoke upto 12months. We identified 2620 proteins in total, of which 671 proteins were differentially expressed (1...
October 14, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28868182/assessment-of-serum-angiogenic-factors-as-a-diagnostic-aid-for-small-bowel-angiodysplasia-in-patients-with-obscure-gastrointestinal-bleeding-and-anaemia
#12
Grainne Holleran, Mary Hussey, Sinead Smith, Deirdre McNamara
AIM: To assess the use of serum levels of angiopoietin-1 (Ang1), Ang2 and tumor necrosis factor-α (TNFα) as predictive factors for small bowel angiodysplasia (SBA). METHODS: Serum samples were collected from patients undergoing capsule endoscopy for any cause of obscure gastrointestinal bleeding (OGIB) or anaemia. Based on small bowel findings patients were divided into 3 groups: (1) SBA; (2) other bleeding causes; and (3) normal, according to diagnosis. Using ELISA technique we measured serum levels of Ang1, Ang2 and TNFα and compared mean and median levels between the groups based on small bowel diagnosis...
August 15, 2017: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/28844670/goose-fmo3-gene-cloning-tissue-expression-profiling-polymorphism-detection-and-association-analysis-with-trimethylamine-level-in-the-egg-yolk
#13
Hang Zhong, Yi Luo, Jing Sun, Chao Wang, Qi-Gui Wang, Guang-Liang Gao, Ke-Shan Zhang, Qin Li, Hai-Wei Wang, Jing Li, Ming-Jun Chen, Yang-Ming Wang, Xian-Zhi Zhao
Flavin-containing monooxygenase 3 (FMO3) plays a critical role in catalyzing the conversion of trimethylamine (TMA) to trimethylamine-N-oxide (TMAO) in vivo. Despite the well-documented association between FMO3 mutations and a 'fishy' off-flavor eggs in chicken and quail, little information is available regarding the molecular characteristic of goose (Anser cygnoides) FMO3 and its relationship with the yolk TMA content. To fill these gaps, we cloned the full-length cDNA sequence of goose FMO3, which comprised 1851bp encoding 531 amino acids...
October 20, 2017: Gene
https://www.readbyqxmd.com/read/28843841/relationship-between-time-post-ovulation-and-progesterone-on-oocyte-maturation-and-pregnancy-in-canine-cloning
#14
Joung Joo Kim, Kang Bae Park, Eun Ji Choi, Sang Hwan Hyun, Nam-Hyung Kim, Yeon Woo Jeong, Woo Suk Hwang
Canine oocytes ovulated at prophase complete meiosis and continue to develop in presence of a high progesterone concentration in the oviduct. Considering that meiotic competence of canine oocyte is accomplished in the oviductal environment, we postulate that hormonal milieu resulting from the circulating progesterone concentration may affect oocyte maturation and early development of embryos. From 237 oocyte donors, 2620 oocytes were collected and their meiotic status and morphology were determined. To determine optimal characteristics of the mature oocytes subjected to nuclear transfer, a proportion of the meiotic status of the oocytes were classified in reference to time post-ovulation as well as progesterone (P4) level...
October 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28834851/incidence-and-fusion-of-os-trigonum-in-a-healthy-pediatric-population
#15
Derrick M Knapik, Sahejmeet S Guraya, Jessica A Jones, Daniel R Cooperman, Raymond W Liu
BACKGROUND: Accessory ossicles off the talus (os trigonum) are a common radiographic finding seen within the foot with variable symptomatology in adult and pediatric patients. Although most studies have examined the incidence of these anatomic variants in a retrospective manner, few have longitudinally followed the behavior of os trigonum over time. The aim of this study was to investigate the incidence, mean age of appearance and fusion, and fusion rate of os trigonum in a large cohort of asymptomatic pediatric patients...
August 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28753948/selective-detection-of-target-volatile-organic-compounds-in-contaminated-humid-air-using-a-sensor-array-with-principal-component-analysis
#16
Toshio Itoh Takafumi Akamatsu, Akihiro Tsuruta, Woosuck Shin
We investigated selective detection of the target volatile organic compounds (VOCs) nonanal, n-decane, and acetoin for lung cancer-related VOCs, and acetone and methyl i-butyl ketone for diabetes-related VOCs, in humid air with simulated VOC contamination (total concentration: 300 μg/m³). We used six "grain boundary-response type" sensors, including four commercially available sensors (TGS 2600, 2610, 2610, and 2620) and two Pt, Pd, and Au-loaded SnO₂ sensors (Pt, Pd, Au/SnO₂), and two "bulk-response type" sensors, including Zr-doped CeO₂ (CeZr10), i...
July 19, 2017: Sensors
https://www.readbyqxmd.com/read/28648543/seasonal-influenza-vaccine-effectiveness-against-laboratory-confirmed-influenza-hospitalizations-latin-america-2013
#17
Nathalie El Omeiri, Eduardo Azziz-Baumgartner, Mark G Thompson, Wilfrido Clará, Mauricio Cerpa, Rakhee Palekar, Sara Mirza, Alba María Ropero-Álvarez
BACKGROUND: Despite widespread utilization of influenza vaccines, effectiveness (VE) has not been routinely measured in Latin America. METHODS: We used a case test-negative control design to estimate trivalent inactivated influenza VE against laboratory-confirmed influenza among hospitalized children aged 6months-5years and adults aged ≥60years which are age-groups targeted for vaccination. We sought persons with severe acute respiratory infections (SARI), hospitalized at 71 sentinel hospitals in Argentina, Brazil, Chile, Colombia, Costa Rica, El Salvador, Honduras, Panama, and Paraguay during January-December 2013...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28549168/assessing-the-thermal-dissipation-sap-flux-density-method-for-monitoring-cold-season-water-transport-in-seasonally-snow-covered-forests
#18
Allison M Chan, David R Bowling
Productivity of conifers in seasonally snow-covered forests is high before and during snowmelt when environmental conditions are optimal for photosynthesis. Climate change is altering the timing of spring in many locations, and changes in the date of transition from winter dormancy can have large impacts on annual productivity. Sap flow methods provide a promising approach to monitor tree activity during the cold season and the winter-spring and fall-winter transitions. Although sap flow techniques have been widely used, cold season results are generally not reported...
July 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28467476/early-onset-hyperuricemia-is-a-prognostic-marker-for-kidney-graft-failure-propensity-score-matching-analysis-in-a-korean-multicenter-cohort
#19
MULTICENTER STUDY
Miyeun Han, Jung Pyo Lee, Seokwoo Park, Yunmi Kim, Yong Chul Kim, Curie Ahn, Duck Jong Han, Jongwon Ha, In Mok Jung, Chun Soo Lim, Yon Su Kim, Young Hoon Kim, Yun Kyu Oh
It remains inconclusive whether hyperuricemia is a true risk factor for kidney graft failure. In the current study, we investigated the association of hyperuricemia and graft outcome. We performed a multi-center cohort study that included 2620 kidney transplant recipients. The patients were classified as either normouricemic or hyperuricemic at 3 months after transplantation. Hyperuricemia was defined as a serum uric acid level ≥ 7.0 mg/dL in males or ≥ 6.0 mg/dL in females or based on the use of urate-lowering medications...
2017: PloS One
https://www.readbyqxmd.com/read/28403873/weight-change-during-chemotherapy-in-breast-cancer-patients-a-meta-analysis
#20
M M G A van den Berg, R M Winkels, J Th C M de Kruif, H W M van Laarhoven, M Visser, J H M de Vries, Y C de Vries, E Kampman
BACKGROUND: Weight gain during chemotherapy in women with breast cancer is commonly reported. However, there are important differences between studies that examined weight change during chemotherapy; e.g. type of chemotherapy, menopausal status, time between body weight measurements and sample size. The purpose of this meta-analysis was to quantify changes in body weight during chemotherapy for women with breast cancer, taking these differences into account. METHODS: We identified relevant studies using PubMed, Scopus and Embase databases...
April 12, 2017: BMC Cancer
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