keyword
MENU ▼
Read by QxMD icon Read
search

2620

keyword
https://www.readbyqxmd.com/read/29744818/real-world-clinical-effectiveness-and-cost-savings-of-liraglutide-versus-sitagliptin-in-treating-type-2-diabetes-for-1-and-2-years
#1
Qian Li, Rahul Ganguly, Michael L Ganz, Cory Gamble, Tam Dang-Tan
INTRODUCTION: This study compared the clinical and economic outcomes of long-term use of liraglutide versus sitagliptin for the treatment of type 2 diabetes (T2DM) in real-world practice in the USA. METHODS: We identified adult patients (≥ 18 years old) with T2DM who initiated liraglutide or sitagliptin in 2010-2014 using a large claims database. Quarterly glycemic control measures and annual healthcare costs were assessed during the 1st and 2nd years of persistent medication use...
May 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29723441/pharmacokinetic-and-pharmacodynamic-correlations-from-2-studies-evaluating-abuse-potential-of-hydrocodone-extended-release-tablets
#2
Kerri A Schoedel, Michael Gillespie, Naama Levy-Cooperman, Megan J Shram, Laura Rabinovich-Guilatt
Pharmacokinetic (PK)/pharmacodynamic (PD) correlations were explored in 2 human abuse potential studies of orally and intranasally administered hydrocodone extended-release (ER) 45 mg in healthy, nondependent opioid users. In a crossover study design, subjects received intact hydrocodone ER, finely milled hydrocodone ER, and hydrocodone powder in solution in the oral study and finely milled hydrocodone ER, hydrocodone powder, and finely milled Zohydro® ER in the intranasal study. Spearman ρ2 and Pearson r2 values were calculated for PD (maximum effect [Emax ] for "at the moment" Drug Liking, Overall Drug Liking, and Take Drug Again visual analog scales [VAS]) vs PK (partial area under the concentration-time curve [AUC], maximum drug concentration [Cmax ], time to Cmax [Tmax ], and abuse quotient [PK AQ; Cmax /Tmax ]) for all treatments...
May 3, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29667324/estimation-of-cost-savings-between-2011-and-2014-attributed-to-infliximab-biosimilar-in-the-south-korean-healthcare-market-real-world-evidence-using-a-nationwide-database
#3
Jiyoun Kim, Dongmun Ha, Inmyung Song, Haesun Park, Sang-Won Lee, Eui-Kyung Lee, Ju-Young Shin
AIM: The introduction of biosimilars is expected to reduce the cost of biologic drugs, but the actual cost savings have not yet been quantified in Korea. The aim of this study was to estimate the annual cost savings attributed to the introduction of infliximab biosimilar. METHODS: We conducted a retrospective analysis using data from the Health Insurance Review and Assessment Service-National Patients Sample (HIRA-NPS) between 2011 and 2014. The study subjects were patients who were treated with infliximab, adalimumab or etanercept...
April 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29595038/the-relationship-between-lower-urinary-tract-symptoms-and-irritable-bowel-syndrome-a-meta-analysis-of-cross-sectional-studies
#4
Zhihu Li, Wei Huang, Xiaoyan Wang, Yong Zhang
INTRODUCTION: While several epidemiologic studies have investigated the relationship between lower urinary tract symptoms (LUTS) and irritable bowel syndrome (IBS), it remains unclear. To investigate the relationship between IBS and LUTS, a systematic review and meta-analysis of cross-sectional studies were undertaken. EVIDENCE ACQUISITION: Online databases were searched up to 1, December, 2017 for cross-sectional studies that evaluated the association between IBS and the risk of LUTS...
March 28, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29408531/the-polymorphism-rs671-at-aldh2-associated-with-serum-uric-acid-levels-in-chinese-han-males-a-genome-wide-association-study
#5
Dandan Zhang, Min Yang, Dan Zhou, Zhenli Li, Libin Cai, Yuqian Bao, Hong Li, Zhongyan Shan, Juan Liu, Duo Lv, Yi Liu, Chunxiao Xu, Jie Ling, Yuyang Xu, Shuai Zhang, Qiong Huang, Yongyong Shi, Yimin Zhu, Maode Lai
Serum uric acid (SUA) levels are highly heritable and an increased SUA level is one of important risk factors for gout, diabetes, metabolic syndrome, and cardiovascular diseases. The genetic variants underlying SUA remains largely unexplored. The aim was to explore new genetic variants underlying SUA in Chinese Han. We performed a genome-wide association study of SUA levels in Han Chinese. The discovery set contained 1634 samples and subsequent replication was comprised of 1649 females and 1169 males. 2620 subjects were recruited in the detailed analysis of rs671, alcohol drinking and SUA...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29363771/determining-degree-of-roasting-in-cocoa-beans-by-artificial-neural-network-ann-based-electronic-nose-system-and-gas-chromatography-mass-spectrometry-gc-ms
#6
Juzhong Tan, William L Kerr
BACKGROUND: Roasting is a critical step in chocolate processing, where moisture content is decreased and unique flavors and texture are developed. The determination of the degree of roasting in cocoa beans is important to ensure the quality of chocolate. Determining the degree of roasting relies on human specialists or sophisticated chemical analyses that are inaccessible to small manufacturers and farmers. In this study, an electronic nose system was constructed consisting of an array of gas sensors and used to detect volatiles emanating from cocoa beans roasted for 0, 20, 30 and 40 min...
January 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29348480/association-between-plasma-concentrations-of-branched-chain-amino-acids-and-adipokines-in-japanese-adults-without-diabetes
#7
Ryoko Katagiri, Atsushi Goto, Sanjeev Budhathoki, Taiki Yamaji, Hiroshi Yamamoto, Yumiko Kato, Motoki Iwasaki, Shoichiro Tsugane
Previous studies have consistently reported an association between circulating levels of branched-chain amino acids (BCAAs) or adipokines and insulin resistance; however, the association between BCAA and adipokine levels remains to be clarified. In this cross-sectional study involving 678 participants (435 men) without diabetes, plasma BCAA (valine, leucine, and isoleucine), adipokine (total and high molecular weight [HMW] adiponectin, leptin, and tumor necrosis factor-α [TNF-α]) concentrations, and an updated homeostasis model assessment of insulin resistance (HOMA2-IR) were measured...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321831/changes-in-smoking-prevalence-and-cessation-support-and-factors-associated-with-successful-smoking-cessation-in-swedish-patients-with-asthma-and-copd
#8
Marcus Stegberg, Mikael Hasselgren, Scott Montgomery, Karin Lisspers, Björn Ställberg, Christer Janson, Josefin Sundh
Introduction : Our aim was to investigate changes in smoking prevalence, smoking cessation support and factors associated with successful smoking cessation in patients with asthma and COPD. Methods : Questionnaires about available smoking cessation resources were completed by 54 primary health-care centers and 14 hospitals in central Sweden in 2005 and 2012. Patient data were collected using record reviews and patients questionnaires for two cohorts of randomly selected asthma and COPD patients in 2005 ( n  = 2306; with a follow up in 2012), and in 2014/2015 ( n  = 2620)...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29315968/cuffed-endotracheal-tubes-in-infants-less-than-3-kg-a-retrospective-cohort-study
#9
Rebecca E Thomas, Shripada C Rao, Corrado Minutillo, Bruce Hullett, Max K Bulsara
BACKGROUND: Cuffed endotracheal tubes are being increasingly used in infants; however, current evidence in the literature mostly includes infants ≥ 3-kg weight. AIMS: The aim of this observational study was to compare the short-term outcomes with the use of Microcuff® cuffed vs uncuffed endotracheal tubes in neonates < 3 kg. METHODS: We performed a retrospective cohort study in a single-centre, tertiary children's hospital neonatal intensive care unit...
March 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29279178/radiologic-discrepancies-in-children-with-special-healthcare-needs-in-a-pediatric-emergency-department
#10
Ara Festekjian, Karen Y Kwan, Todd P Chang, Hollie Lai, Margil Fahit, Danica B Liberman
BACKGROUND: After-hours radiologic interpretation by nonradiology attendings or resident radiologists introduces the risk of discrepancies. Clinical outcomes following radiologic discrepancies among pediatric emergency department (ED) patients are poorly described. In particular, children with special healthcare needs (CSHCN), have more opportunities for discrepancies and potential consequences than non- CSHCN. Our objective was to determine the rates and types of radiologic discrepancies, and to compare CSHCN to non-CSHCN...
December 21, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29189958/surgical-treatment-of-spinal-metastases-from-renal-cell-carcinoma-effects-of-preoperative-embolization-on-intraoperative-blood-loss
#11
Matthias Reitz, Klaus Christian Mende, Christopher Cramer, Theresa Krätzig, ZSuzsanna Nagy, Eik Vettorazzi, Sven Oliver Eicker, Marc Dreimann
The objective of this paper is analyzing the effects of preoperative embolization on intraoperative blood loss in spinal surgery for renal cell carcinoma (RCC) metastasis and identifying factors contributing to an increased blood loss in the surgical procedure. A retrospective analysis was performed in patients who were treated in for spinal metastasis from RCC between 2011 and 2016. Factors analyzed were reduction of tumor blush, timing of embolization, selective vs. superselective approach, surgical factors, and tumor volume and localization...
November 30, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29180125/clinical-and-microbiological-characteristics-of-the-infections-in-patients-treated-with-rituximab-for-autoimmune-and-or-malignant-hematological-disorders
#12
REVIEW
Jean-Jacques Tudesq, Guillaume Cartron, Sophie Rivière, David Morquin, Laura Iordache, Alfred Mahr, Valérie Pourcher, Kada Klouche, Diane Cerutti, Alain Le Quellec, Philippe Guilpain
INTRODUCTION: Rituximab is commonly used for the treatment of hematological malignancies and autoimmune diseases. Despite a reputation for good tolerance, case-series and registries reported rituximab-related infections of variable severity including opportunistic infections. We aimed at describing the natural history of infectious events (IE) after treatment by rituximab providing clinical and microbiological features and outcome. PATIENTS AND METHODS: We retrospectively analyzed the medical records of patients treated with rituximab in an internal medicine department of a tertiary hospital between 2007 and 2015, and identified all IE after this therapy...
February 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29160159/reported-habitual-intake-of-breakfast-and-selected-foods-in-relation-to-overweight-status-among-seven-to-nine-year-old-swedish-children
#13
Bente B Nilsen, Agneta Yngve, Celia Monteagudo, Richard Tellström, Henrik Scander, Bo Werner
AIM: The aim of this study was to examine the reported frequency of breakfast intake and selected food and beverages in the investigated group of Swedish children in comparison with recommended intakes. Furthermore, the study analyses these food habits and some demographic and lifestyle factors in relation to overweight and obesity. METHODS: This cross-sectional study builds on data collected in 2008 and 2010. Measured anthropometric data and parent questionnaire data were collected...
December 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29157150/assessment-of-urinary-protein-composition-in-response-to-consecutive-days-of-wildland-firefighting
#14
Nobuo Yasuda, Brent C Ruby
The purpose of this study was to examine the pattern of urinary protein excretion induced by 3 consecutive days of wildland firefighting. Eighteen male active-duty military personnel served as the participants. All testing on the 3 consecutive days was conducted at a Northwestern USA fire camp. All participants consumed military-based foods containing 2620-2864 kcal/day. The work activity was evaluated with an accelerometer in association with body weight and hydration markers over the experimental period...
February 5, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29120285/women-s-satisfaction-and-perception-of-control-in-childbirth-in-three-arab-countries
#15
Tamar Kabakian-Khasholian, Hyam Bashour, Amina El-Nemer, Mayada Kharouf, Salah Sheikha, Nasser El Lakany, Rafik Barakat, Ohoud Elsheikh, Nadia Nameh, Rabih Chahine, Anayda Portela
Women's satisfaction and perceived control in childbirth are important attributes of the childbirth experience and quality of care indicators. This article presents findings from the pre-intervention phase of a multi-centre implementation study in Egypt, Lebanon and Syria, to introduce a labour companionship model in these countries. A sample of 2620 women giving birth in three public teaching hospitals from November 2014 to July 2015 in Beirut and Mansoura, and from November 2014 to April 2015 in Damascus were interviewed by trained field workers...
October 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29068678/efficient-and-accurate-born-oppenheimer-molecular-dynamics-for-large-molecular-systems
#16
Laurens D M Peters, Jörg Kussmann, Christian Ochsenfeld
An efficient scheme for the calculation of Born-Oppenheimer molecular dynamics (BOMD) simulations is introduced. It combines the corrected small basis set Hartree-Fock (HF-3c) method by Sure and Grimme [J. Comput. Chem. 2013, 43, 1672], extended Lagrangian BOMD (XL-BOMD) by Niklasson et al. [J. Chem. Phys. 2009, 130, 214109], and the calculation of the two electron integrals on graphics processing units (GPUs) [J. Chem. Phys. 2013, 138, 134114; J. Chem. Theory Comput. 2015, 11, 918]. To explore the parallel performance of our strong scaling implementation of the method, we present timings and extract, as its validation and first illustrative application, high-quality vibrational spectra from simulated trajectories of β-carotene, paclitaxel, and liquid water (up to 500 atoms)...
November 14, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29042306/cigarette-smoke-induces-mitochondrial-metabolic-reprogramming-in-lung-cells
#17
Hitendra S Solanki, Niraj Babu, Ankit P Jain, Mohd Younis Bhat, Vinuth N Puttamallesh, Jayshree Advani, Remya Raja, Kiran K Mangalaparthi, Mahesh M Kumar, T S Keshava Prasad, Premendu Prakash Mathur, David Sidransky, Harsha Gowda, Aditi Chatterjee
Cellular transformation owing to cigarette smoking is due to chronic exposure and not acute. However, systematic studies to understand the molecular alterations in lung cells due to cigarette smoke are lacking. To understand these molecular alterations induced by chronic cigarette smoke exposure, we carried out tandem mass tag (TMT) based temporal proteomic profiling of lung cells exposed to cigarette smoke for upto 12months. We identified 2620 proteins in total, of which 671 proteins were differentially expressed (1...
May 2018: Mitochondrion
https://www.readbyqxmd.com/read/28868182/assessment-of-serum-angiogenic-factors-as-a-diagnostic-aid-for-small-bowel-angiodysplasia-in-patients-with-obscure-gastrointestinal-bleeding-and-anaemia
#18
Grainne Holleran, Mary Hussey, Sinead Smith, Deirdre McNamara
AIM: To assess the use of serum levels of angiopoietin-1 (Ang1), Ang2 and tumor necrosis factor-α (TNFα) as predictive factors for small bowel angiodysplasia (SBA). METHODS: Serum samples were collected from patients undergoing capsule endoscopy for any cause of obscure gastrointestinal bleeding (OGIB) or anaemia. Based on small bowel findings patients were divided into 3 groups: (1) SBA; (2) other bleeding causes; and (3) normal, according to diagnosis. Using ELISA technique we measured serum levels of Ang1, Ang2 and TNFα and compared mean and median levels between the groups based on small bowel diagnosis...
August 15, 2017: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/28844670/goose-fmo3-gene-cloning-tissue-expression-profiling-polymorphism-detection-and-association-analysis-with-trimethylamine-level-in-the-egg-yolk
#19
Hang Zhong, Yi Luo, Jing Sun, Chao Wang, Qi-Gui Wang, Guang-Liang Gao, Ke-Shan Zhang, Qin Li, Hai-Wei Wang, Jing Li, Ming-Jun Chen, Yang-Ming Wang, Xian-Zhi Zhao
Flavin-containing monooxygenase 3 (FMO3) plays a critical role in catalyzing the conversion of trimethylamine (TMA) to trimethylamine-N-oxide (TMAO) in vivo. Despite the well-documented association between FMO3 mutations and a 'fishy' off-flavor eggs in chicken and quail, little information is available regarding the molecular characteristic of goose (Anser cygnoides) FMO3 and its relationship with the yolk TMA content. To fill these gaps, we cloned the full-length cDNA sequence of goose FMO3, which comprised 1851bp encoding 531 amino acids...
October 20, 2017: Gene
https://www.readbyqxmd.com/read/28843841/relationship-between-time-post-ovulation-and-progesterone-on-oocyte-maturation-and-pregnancy-in-canine-cloning
#20
Joung Joo Kim, Kang Bae Park, Eun Ji Choi, Sang Hwan Hyun, Nam-Hyung Kim, Yeon Woo Jeong, Woo Suk Hwang
Canine oocytes ovulated at prophase complete meiosis and continue to develop in presence of a high progesterone concentration in the oviduct. Considering that meiotic competence of canine oocyte is accomplished in the oviductal environment, we postulate that hormonal milieu resulting from the circulating progesterone concentration may affect oocyte maturation and early development of embryos. From 237 oocyte donors, 2620 oocytes were collected and their meiotic status and morphology were determined. To determine optimal characteristics of the mature oocytes subjected to nuclear transfer, a proportion of the meiotic status of the oocytes were classified in reference to time post-ovulation as well as progesterone (P4) level...
October 2017: Animal Reproduction Science
keyword
keyword
75885
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"