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https://www.readbyqxmd.com/read/28088009/cardiac-output-and-systemic-vascular-resistance-clinical-assessment-compared-with-a-noninvasive-objective-measurement-in-children-with-shock
#1
Asma Razavi, Christopher J L Newth, Robinder G Khemani, Fernando Beltramo, Patrick A Ross
PURPOSE: To evaluate physician assessment of cardiac output and systemic vascular resistance in patients with shock compared with an ultrasonic cardiac output monitor (USCOM). To explore potential changes in therapy decisions if USCOM data were available using physician intervention answers. STUDY DESIGN: Double-blinded, prospective, observational study in a tertiary hospital pediatric intensive care unit. Forty children (<18years) admitted with shock, requiring ongoing volume resuscitation or inotropic support...
December 28, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28068857/abobotulinumtoxina-dysport-%C3%A2-improves-function-according-to-goal-attainment-in-children-with-dynamic-equinus-due-to-cerebral-palsy
#2
Ann Tilton, Barry Russman, Resa Aydin, Umit Dincer, Raul G Escobar, Sehim Kutlay, Zbigniew Lipczyk, Juan Carlos Velez, Anne-Sophie Grandoulier, Anissa Tse, Philippe Picaut, Mauricio R Delgado
This secondary analysis of a large (n = 241), randomized, double-blind study evaluated the efficacy of 2 doses of abobotulinumtoxinA + standard of care (SOC) versus placebo + SOC in enabling children with dynamic equinus due to cerebral palsy to achieve their functional goals using Goal Attainment Scaling. Most parents/caregivers selected goals targeting aspects of gait improvement as most relevant. Mean (95% confidence interval) Goal Attainment Scaling T scores at week 4 were higher for both abobotulinumtoxinA groups versus placebo (treatment difference vs placebo: 10 U/kg/leg: 5...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28063938/brincidofovir-for-asymptomatic-adenovirus-viremia-in-pediatric-and-adult-allogeneic-hematopoietic-cell-transplant-recipients-a-randomized-placebo-controlled-phase-ii-trial
#3
Michael S Grimley, Roy F Chemaly, Janet A Englund, Joanne Kurtzberg, Gregory Chittick, Thomas M Brundage, Andrew Bae, Marion E Morrison, Vinod K Prasad
Adenovirus infection in immunocompromised patients contributes to significant morbidity and mortality, especially after allogeneic hematopoietic cell transplantation (HCT). Brincidofovir (BCV, CMX001) is an orally bioavailable lipid conjugate of cidofovir that has in vitro activity against adenoviruses and other double-stranded DNA viruses. This randomized placebo-controlled phase II trial evaluated pre-emptive treatment with BCV for the prevention of adenovirus disease in pediatric and adult allogeneic HCT recipients with asymptomatic adenovirus viremia...
January 5, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28043488/development-of-the-food-supplement-nyaditum-resae-as-a-new-tool-to-reduce-the-risk-of-tuberculosis-development
#4
Nestani Tukvadze, Paula Cardona, Sergo Vashakidze, Natalia Shubladze, Zaza Avaliani, Cris Vilaplana, Pere-Joan Cardona
Nyaditum resae (NR) is a galenic preparation of heat-killed Mycobacterium manresensis (hkMn). This is a new species that belongs to the Mycobacterium fortuitum complex, and it is present in drinking water-thus, regulatorily speaking, it is considered a food supplement. Preclinical studies in the murine model of active tuberculosis (TB) in the C3HeB/FeJ strain have demonstrated that daily administration of NR containing 10(3)-10(6)hkMn for 14days was able to stop the progression toward active TB [1]. The mechanism of action was linked to the induction of low dose tolerance and was related to the increase of Tuberculin Purified Protein Derivative (PPD) memory-specific Tregs (CD4(+)CD25(+)CD39(+) cells) after ex vivo incubation of splenocytes for 7days...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28041747/autologous-fat-grafting-does-not-improve-burn-scar-appearance-a-prospective-randomized-double-blinded-placebo-controlled-pilot-study
#5
Shaili Gal, Jesus Ignacio Ramirez, Pirko Maguina
OBJECTIVE: It has been proposed that fat grafts can improve the appearance of mature burn scars. The pluripotent progenitor cells contained within autologous adipose tissue grafts are believed to induce skin repair and improve scar appearance. We conducted a prospective, randomized, double-blinded, placebo-controlled study to evaluate the effects of fat grafts on the appearance of mature burn scars. METHODS: Pediatric burn survivors with mature scars were recruited for this study...
December 29, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28012528/the-effect-of-iv-dexamethasone-versus-local-anesthetic-infiltration-technique-in-postoperative-nausea-and-vomiting-after-tonsillectomy-in-children-a-randomized-double-blind-clinical-trial
#6
Zoher Naja, Saleh Kanawati, Rania Al Khatib, Fouad Ziade, Zeina Z Naja, Ahmad Salah Naja, Mariam Rajab
BACKGROUND: Local anesthetic infiltration and corticosteroids had shown effectiveness in reducing post tonsillectomy nausea, vomiting and pain. OBJECTIVES: To compare the effect of intravenous dexamethasone versus pre-incision infiltration of local anesthesia in pediatric tonsillectomy on postoperative nausea and vomiting (PONV). The secondary objective was postoperative pain. METHODS: A randomized double-blind clinical trial was conducted at a tertiary care teaching hospital...
January 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28007665/cd25-blockade-delays-regulatory-t-cell-reconstitution-and-does-not-prevent-graft-versus-host-disease-after-allogeneic-hematopoietic-cell-transplantation
#7
Frederick L Locke, Joseph Pidala, Barry Storer, Paul J Martin, Michael A Pulsipher, Thomas R Chauncey, Niels Jacobsen, Nicolaus Kröger, Irwin Walker, Susan Light, Bronwen E Shaw, Francisca Beato, Ginna G Laport, Auayporn Nademanee, Armand Keating, Gerard Socie, Claudio Anasetti
Daclizumab, a humanized monoclonal antibody, binds CD25 and blocks formation of the IL-2 receptor on T cells. A study of daclizumab as acute graft-versus-host disease (GVHD) prophylaxis after unrelated bone marrow transplantation was conducted before the importance of CD25(+)FOXP3(+) regulatory T cells (Tregs) was recognized. Tregs can abrogate the onset of GVHD. The relation between Tregs and a graft-versus-malignancy effect is not fully understood. An international, multicenter, double-blind clinical trial randomized 210 adult or pediatric patients to receive 5 weekly doses of daclizumab at 0...
December 19, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28006041/efficacy-and-safety-of-ciprofloxacin-plus-fluocinolone-in-otitis-media-with-tympanostomy-tubes-in-pediatric-patients-a-randomized-clinical-trial
#8
Zorik Spektor, Felix Pumarola, Khaleed Ismail, Brent Lanier, Iftikhar Hussain, John Ansley, Henry F Butehorn, Kenneth Esterhuizen, John Byers, Franklin Douglis, Bryan Lansford, F Javier Hernández
Importance: Acute otitis media with tympanostomy tubes (AOMT) in children commonly presents with otorrhea and negatively affects their daily activities. Objective: To evaluate the efficacy and safety of topical ciprofloxacin, 0.3%, plus fluocinolone acetonide, 0.025%, otic solution relative to ciprofloxacin, 0.3%, otic solution alone and fluocinolone acetonide, 0.025%, otic solution alone in the treatment of AOMT in children. Design, Setting, and Participants: Two twin multicenter, randomized, double-blind clinical trials with identical designs were conducted from June 24, 2011, through June 23, 2014, at ear, nose, and throat pediatric practices, general practices, hospitals, and clinical research centers...
December 22, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28002391/starter-formula-enriched-in-prebiotics-and-probiotics-ensures-normal-growth-of-infants-and-promotes-gut-health-a-randomized-clinical-trial
#9
Michael Radke, Jean-Charles Picaud, Andrea Loui, Gilles Cambonie, Dirk Faas, Harry N Lafeber, Nanda de Groot, Sophie S Pecquet, Philippe G Steenhout, Jean-Michel Hascoet
BACKGROUND: Prebiotics and probiotics exert beneficial effects by modulating gut microbiota and immune system. This study evaluates efficacy and safety of an infant formula containing Bovine Milk-derived Oligosaccharides (BMOS) and B. lactis (CNCM I-3446) on incidence of diarrhea and febrile infections during the first year of life (primary outcome). METHODS: Full-term infants receiving Test or Control (without BMOS and B. lactis) formula were enrolled in a multi-center, randomized, controlled, double-blind trial with a reference breastfeeding group...
December 21, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27974224/social-emotional-development-of-toddlers-randomized-controlled-trial-of-an-office-based-intervention
#10
Donna Hallas, Mary Koslap-Petraco, Jason Fletcher
PURPOSE: During the toddler years, temper tantrums and impulsive behaviors are the norm. These behaviors can frustrate even the most experienced mothers. DESIGN AND METHODS: A prospective, double blind, randomized controlled trial using pre-test/post-test experimental design was used to examine the effectiveness of an office-based educational program to improve maternal confidence and the social-emotional development of toddlers. The Toddler Care Questionnaire (TCQ) was administered to all mothers as a pre and post intervention test...
December 11, 2016: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/27940664/inhaled-laninamivir-octanoate-as-prophylaxis-for-influenza-in-children
#11
Takashi Nakano, Naruhiko Ishiwada, Tokuhito Sumitani, Mitsutoshi Uemori, Koji Isobe
BACKGROUND: A single 20-mg dose of inhaled laninamivir octanoate is an effective treatment of influenza. However, the efficacy of laninamivir octanoate for the prevention of influenza in children <10 years of age has not yet been established. METHODS: We conducted a double-blind, multicenter, randomized, placebo-controlled study to determine whether the efficacy of a single 20-mg dose of inhaled laninamivir octanoate to prevent the development of influenza was superior to that of placebo as prophylaxis for influenza in pediatric (<10 years) household members of index cases...
December 2016: Pediatrics
https://www.readbyqxmd.com/read/27928238/conscious-sedation-efficacy-of-0-3-and-0-5-mg-kg-oral-midazolam-for-three-to-six-year-old-uncooperative-children-undergoing-dental-treatment-a-clinical-trial
#12
Masoud Fallahinejad Ghajari, Ghassem Ansari, Leila Hasanbeygi, Shahnaz Shayeghi
OBJECTIVES: Midazolam with variable dosages has been used to induce sedation in pediatric dentistry. The aim of this study was to compare the efficacy of two dosages of oral midazolam for conscious sedation of children undergoing dental treatment. MATERIALS AND METHODS: In this randomized crossover double blind clinical trial, 20 healthy children (ASA I) aged three to six years with definitely negative Frankl behavioral rating scale were evaluated. Half of the children received 0...
March 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27906800/lactobacillus-reuteri-dsm-17938-in-the-treatment-of-functional-abdominal-pain-in-children-rct-study
#13
Oleg Jadrešin, Iva Hojsak, Zrinjka Mišak, Alemka Jaklin Kekez, Tena Trbojević, Lana Ivković, Sanja Kolaček
OBJECTIVES: Beneficial therapeutic effect of probiotics has been reported in children with the irritable bowel syndrome (IBS) but not consistently in other functional abdominal pain-related disorders. The aim of this study was to investigate the effect of Lactobacillus (L.) reuteri DSM 17938 in the treatment of functional abdominal pain (FAP) and IBS in children. METHODS: Children (age 4-18 years) referred to pediatric gastroenterologist at Children's Hospital Zagreb from May 2012 to December 2014, diagnosed as FAP or IBS, were randomized to receive L...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27880811/oral-ondansetron-versus-domperidone-for-acute-gastroenteritis-in-pediatric-emergency-departments-multicenter-double-blind-randomized-controlled-trial
#14
Federico Marchetti, Maurizio Bonati, Alessandra Maestro, Davide Zanon, Francesca Rovere, Alberto Arrighini, Egidio Barbi, Paolo Bertolani, Paolo Biban, Liviana Da Dalt, Andrea Guala, Elisa Mazzoni, Anna Pazzaglia, Paolo Francesco Perri, Antonino Reale, Salvatore Renna, Antonio Francesco Urbino, Enrico Valletta, Antonio Vitale, Tiziana Zangardi, Antonio Clavenna, Luca Ronfani
The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in children with gastroenteritis. After failure of initial oral rehydration administration, children aged 1-6 years admitted for gastroenteritis to the pediatric emergency departments of 15 hospitals in Italy were randomized to receive one oral dose of ondansetron (0...
2016: PloS One
https://www.readbyqxmd.com/read/27875526/caphosol-for-prevention-of-oral-mucositis-in-pediatric-myeloablative-haematopoietic-cell-transplantation
#15
Nathaniel Treister, Michael Nieder, Christina Baggott, Ellen Olson, Lu Chen, Ha Dang, Mark Krailo, Amanda August, Lillian Sung
BACKGROUND: The primary objective was to determine whether topically administered Caphosol, rinsed orally four times daily at the initiation of conditioning, reduces the duration of severe oral mucositis (OM) compared with placebo among children and adolescents undergoing haematopoietic cell transplantation (HCT). METHODS: This was a Children's Oncology Group multicentre randomised double-blinded placebo-controlled clinical trial. Patients between the ages of 4 and 21 years who were scheduled to undergo myeloablative HCT for any indication were randomised to Caphosol or placebo saline rinses four times daily from initiation of conditioning through day +20...
January 3, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27872357/antipyretic-efficacy-and-safety-of-ibuprofen-versus-acetaminophen-suspension-in-febrile-children-results-of-2-randomized-double-blind-single-dose-studies
#16
Shyamalie Jayawardena, David Kellstein
Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7.5 mg/kg or acetaminophen (APAP) suspension 10 to 15 mg/kg. The primary efficacy parameter was time-weighted sum of temperature differences (TWSTD) from baseline through 8 hours for each study. Secondary end points included TWSTD from baseline through 6 hours, time to onset and duration of temperature control, and proportion with temperature control. Studies were pooled for post hoc analyses of efficacy and adverse event end points...
November 20, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27867308/effect-of-n-methyl-d-aspartate-receptor-antagonist-dextromethorphan-on-opioid-analgesia-in-pediatric-intensive-care-unit
#17
Mohammed Naeem, Hala Al Alem, Ali Al Shehri, Majed Al-Jeraisy
Objective. Pain control is an essential goal in the management of critical children. Narcotics are the mainstay for pain control. Patients frequently need escalating doses of narcotics. In such cases an adjunctive therapy may be beneficial. Dextromethorphan (DM) is NMDA receptor antagonist and may prevent tolerance to narcotics; however, its definitive role is still unclear. We sought whether dextromethorphan addition could decrease the requirements of fentanyl to control pain in critical children. Design. Double-blind, randomized control trial (RCT)...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/27859478/effect-of-a-new-treatment-protocol-called-functional-chewing-training-on-chewing-function-in-children-with-cerebral-palsy-a-double-blind-randomised-controlled-trial
#18
S Serel Arslan, N Demir, A A Karaduman
Cerebral palsy (CP) is a group of permanent sensorimotor impairments. Children with CP have various feeding difficulties including chewing disorder, which may affect their nutritional status. Functional Chewing Training (FuCT) was designed as a holistic approach to improve chewing function by providing postural alignment, sensory and motor training, and food and environmental adjustments. This study aimed to investigate the effect of FuCT on chewing function in children with CP. This study was designed as a double-blind, randomised controlled trial...
January 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27847704/treatment-of-postoperative-pain-in-pediatric-operations-comparing-the-efficiency-of-bupivacaine-bupivacaine-dexmedetomidine-and-bupivacaine-fentanyl-for-caudal-block
#19
Hashem Jarineshin, Fereydoon Fekrat, Aida Kargar Kermanshah
BACKGROUND: Caudal analgesia is a common method for postoperative pain management in pediatric patients. Additive agents such as opioids and α2 agonists have been used to enhance the analgesic effects of local anesthetics for caudal block. OBJECTIVES: The aim of this study was to compare the additive effects of dexmedetomidine and fentanyl on bupivacaine-induced caudal analgesia in pediatric patients who had undergone elective inguinal hernia repair. METHODS: This randomized, double-blind clinical trial included children aged 1 - 5 years who were divided into three groups: the bupivacaine group (Group B) received 0...
October 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27846055/a-phase-iii-randomized-double-blind-clinical-trial-of-an-investigational-hexavalent-vaccine-given-at-2-3-4-and-12-months
#20
Timo Vesikari, Thomas Becker, Andre F Vertruyen, Katleen Poschet, Sheryl A Flores, Marco F Pagnoni, Jin Xu, G Frank Liu, Jon E Stek, Florence Boisnard, Stéphane Thomas, Eddy Ziani, Andrew W Lee
BACKGROUND: Combination vaccines simplify vaccination visits and improve coverage and timeliness. DTaP5-HB-IPV-Hib is a new investigational, fully-liquid, combination vaccine containing a 5-antigen pertussis component and which is designed to protect against 6 infectious diseases. METHODS: In this multicenter, double-blind, comparator-controlled, Phase III study (NCT01341639) conducted in Finland, Germany, and Belgium, healthy infants were randomized 1:1 to receive one of two immunization regimens...
November 11, 2016: Pediatric Infectious Disease Journal
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