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https://www.readbyqxmd.com/read/29764491/does-a-low-fodmaps-diet-reduce-symptoms-of-functional-abdominal-pain-disorders-a-systematic-review-in-adult-and-paediatric-population-on-behalf-of-italian-society-of-pediatrics
#1
REVIEW
Rossella Turco, Silvia Salvatore, Erasmo Miele, Claudio Romano, Gian Luigi Marseglia, Annamaria Staiano
BACKGROUND: Despite the rising of the Functional Gastrointestinal Disorders (FGIDs)' incidence in the last years, the etio-pathogenesis of FGIDs remains unclear. The diet seems to play an important role in these disorders. Indeed, at least two thirds of adult patients with Irritable Bowel Syndrome (IBS) and of children with FGIDs perceive their GI symptoms to be food-related. In particular, in the last years, more interest has been focused in the low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyol (FODMAPs) diet...
May 15, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29759424/lung-ultrasound-findings-undetectable-by-chest-radiography-in-children-with-community-acquired-pneumonia
#2
Giulio Iorio, Maria Capasso, Salvatore Prisco, Giuseppe De Luca, Carlo Mancusi, Bruno Laganà, Maria Antonietta Piscopo, Vincenzo Comune
The purpose of our study was to evaluate any differences between lung ultrasonography and chest radiography (CR) images in children with a diagnosis of community-acquired pneumonia (CAP) and, if there are any, to analyze the reasons and possible clinical implications. We reviewed the medical records of patients admitted to the pediatric ward from January 2014 to December 2016 and selected only cases discharged with a diagnosis of CAP who had undergone performed lung ultrasound (LUS) and CR within 24 h of each other...
May 11, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29757016/icatibant-for-the-treatment-of-hereditary-angioedema-with-c1-inhibitor-deficiency-in-adolescents-and-in-children-aged-over-2-years
#3
Henriette Farkas, Kinga Viktória Kőhalmi
Hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) is a rare disorder with life-threatening complications if untreated. It begins during childhood, and reduces the patient's quality of life. Therefore, the availability of an easily administered agent to relieve unpredictable HAE episodes is indispensable for this age group. Areas covered: Randomized, double-blind, placebo-controlled, open-label extensions and prospective observational studies have proven the safety and efficacy of the subcutaneously administered bradykinin B2 receptor antagonist, icatibant, in the acute treatment of HAE episodes in adult C1-INH-HAE patients...
May 14, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29752853/dexmedetomidine-for-the-reduction-of-emergence-delirium-in-children-undergoing-tonsillectomy-with-propofol-anesthesia-a-double-blind-randomized-study
#4
Adelais G Tsiotou, Anna Malisiova, Elena Kouptsova, Maria Mavri, Maria Anagnostopoulou, Evagelia Kalliardou
BACKGROUND: Postanesthesia emergence delirium is a motor agitation state complicating pediatric anesthesia. We investigated the efficacy of dexmedetomidine in reducing emergence delirium in children undergoing tonsillectomy with and without adenoidectomy using total intravenous anesthesia with propofol. METHODS: This was a prospective, single-center, double-blind, randomized study. The primary outcome was the presence or absence of emergence delirium with and without dexmedetomidine...
May 12, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29737796/pancreatic-enzyme-replacement-therapy-pert-in-children-with-persistent-diarrhea-avoidance-of-elemental-diet-need-accessibility-and-costs
#5
Ariani Dewi Widodo, Rianto Setiabudy, Ina S Timan, Saptawati Bardosono, Widdy Winarta, Agus Firmansyah
BACKGROUND AND OBJECTIVES: Persistent diarrhea has been proven to cause pancreatic exocrine insufficiency, due to decreased stimulation to the pancreas caused by prolonged mucosal injury. Pancreatic enzyme replacement therapy (PERT) given in conjunction to regular treatment is thought to be beneficial in replacing this pancreatic enzyme deficiency, avoiding the need of elemental diet. This study aims to evaluate the benefit of PERT in chil-dren with persistent diarrhea. METHODS AND STUDY DESIGN: This is a randomized, two double-blind parallel group, placebo-controlled clinical trial to evaluate the effects of pancreatic enzyme supplementation in persistent diar-rhea...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29727048/multicenter-randomized-double-blind-controlled-trial-to-evaluate-the-efficacy-of-laser-therapy-for-the-treatment-of-severe-oral-mucositis-induced-by-chemotherapy-in-children-lampo-rct
#6
Margherita Gobbo, Federico Verzegnassi, Luca Ronfani, Davide Zanon, Fraia Melchionda, Simone Bagattoni, Alessandra Majorana, Elena Bardellini, Rosamaria Mura, Alessandra Piras, Maria Grazia Petris, Maria Livia Mariuzzi, Angelica Barone, Elisabetta Merigo, Nunzia Decembrino, Marina Consuelo Vitale, Massimo Berger, Patrizia Defabianis, Matteo Biasotto, Giulia Ottaviani, Giulio Andrea Zanazzo
OBJECTIVES: To demonstrate the efficacy of laser photobiomodulation (PBM) compared to that of placebo on severe oral mucositis (OM) in pediatric oncology patients. The primary objective was the reduction of OM grade (World Health Organization [WHO] scale) 7 days after starting PBM. Secondary objectives were reduction of pain, analgesic consumption, and incidence of side effects. METHODS: One hundred and one children with WHO grade > 2 chemotherapy-induced OM were enrolled in eight Italian hospitals...
May 4, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29712666/randomized-phase-2-trial-of-monthly-vitamin-d-to-prevent-respiratory-complications-in-children-with-sickle-cell-disease
#7
Margaret T Lee, Meyer Kattan, Ilene Fennoy, Stephen M Arpadi, Rachel L Miller, Serge Cremers, Donald J McMahon, Jeri W Nieves, Gary M Brittenham
In sickle cell disease, respiratory infection and asthma may lead to respiratory complications that are a leading cause of morbidity and mortality. Vitamin D has anti-infective and immunomodulatory effects that may decrease the risk for respiratory infections, asthma, and acute chest syndrome. We conducted a randomized double-blind active-controlled clinical trial to determine whether monthly oral vitamin D3 can reduce the rate of respiratory events in children with sickle cell disease. Seventy sickle cell subjects, ages 3-20 years, with baseline records of respiratory events over 1 year before randomization, underwent screening...
May 8, 2018: Blood Advances
https://www.readbyqxmd.com/read/29707018/efficacy-of-pre-medication-with-ibuprofen-on-post-operative-pain-after-pulpotomy-in-primary-molars
#8
Lili Shafie, Sara Esmaili, Masoud Parirokh, Abbas Pardakhti, Nouzar Nakhaee, Paul V Abbott, Hamide Barghi
Introduction: Pain management following dental procedures, particularly pulpotomies and extraction, is of great importance in pediatric dentistry. The aim of this study was to investigate the efficacy of pre-treatment with ibuprofen on post-operative pain following pulpotomy of primary molars. Methods and Materials: In a split mouth double-blinded randomized clinical trial, 49 children aging between 6-10 years old were given either ibuprofen or a placebo 45 min prior to the treatment...
2018: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29703354/50-years-ago-in-the-journal-of-pediatrics-comparison-of-orally-absorbable-and-nonabsorbable-antibiotics-in-shigellosis-a-double-blind-study-with-ampicillin-and-neomycin
#9
https://www.readbyqxmd.com/read/29664721/effect-of-adaptive-compression-and-fast-acting-wdrc-strategies-on-sentence-recognition-in-noise-in-mandarin-speaking-pediatric-hearing-aid-users
#10
Haihong Liu, Yuanhu Liu, Ying Li, Xin Jin, Jing Li, Yi Zhou, Wentong Ge, Xin Ni
BACKGROUND: Wide dynamic range compression (WDRC) has been widely used in hearing aid technology. However, several reports indicate that WDRC may improve audibility at the expense of speech intelligibility. As such, a modified amplification compression scheme, named adaptive compression, was developed. However, the effect of compression strategies on speech perception in pediatric hearing aid users has not been clearly reported. PURPOSE: The purpose of the present study was to investigate the effect of adaptive compression and fast-acting WDRC processing strategies on sentence recognition in noise with Mandarin, pediatric hearing aid users...
April 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29629048/prophylactic-effect-of-riboflavin-on-pediatric-migraine-a-randomized-double-blind-placebo-controlled-trial
#11
Ahmad Talebian, Babak Soltani, Hamid Reza Banafshe, Gholam Abbas Moosavi, Motahhareh Talebian, Siamak Soltani
Background and aim: Riboflavin may have an acceptable effect on migraine among children. This study was carried out to determine the prophylactic effect of riboflavin on migraine in children. Methods: This randomized clinical trial study was performed at Shahid Beheshti Hospital in Kashan, Iran from December 2012 to February 2015. Ninety children with migraine were allocated randomly into 3 groups (placebo, low-dose and high-dose riboflavin). The outcomes (frequency, intensity and duration of headaches) were measured at baseline and 12 weeks of medication in each group, and the decrease of them were compared...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29628550/effect-of-pregabalin-premedication-on-emergence-agitation-in-children-after-sevoflurane-anesthesia-a-randomized-controlled-study
#12
Hesham Mohamed Marouf
Background: Emergence agitation (EA) is common in pediatrics after sevoflurane anesthesia. Aims: We intended to study the effect of preoperative pregabalin on EA in pediatrics after sevoflurane anesthesia. Settings and Design: This study design was a prospective randomized controlled double-blinded study. Patients and Methods: Sixty children with American Society of Anesthesiologists physical status Classes I-II, aged 4-10 years, prepared for adenotonsillectomy under sevoflurane anesthesia were randomized to two equal groups (control Group C and pregabalin Group P)...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29619786/comparative-study-of-levobupivacaine-and-bupivacaine-for-bilateral-maxillary-nerve-block-during-pediatric-primary-cleft-palate-surgery-a-randomized-double-blind-controlled-study
#13
Mohamed F Mostafa, Ragaa Herdan, Mohamed Elshazly
BACKGROUND: Cleft lip and palate are common major congenital anomalies. Cleft palate (CP) repair causes pain and needs large doses of intravenous opioids. The risk of postoperative airway obstruction or respiratory depression is high, requiring continuous and vigilant monitoring. The primary outcome was to evaluate the efficacy of using different local anesthetics during bilateral maxillary nerve block (MNB) with general anesthesia on quality of recovery after primary CP repair. We hypothesized that levobupivacaine would be better than bupivacaine...
April 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29598883/effect-of-vitamin-d-and-omega-3-on-nocturnal-enuresis-of-7-15-year-old-children
#14
E Rahmani, M H Eftekhari, M H Fallahzadeh, M Fararouei, S J Massoumi
INTRODUCTION: Nocturnal enuresis is known to be a common urinary bladder complication in children. Recent studies have associated vitamin D and omega-3 insufficiency with nocturnal enuresis. AIM: This was a 2-month randomized, placebo-controlled, double-blind trial to measure the effects of vitamin D, omega-3 supplements, and their combination on nocturnal enuresis among 7-15-year-old children. MATERIALS AND METHODS: Participants (180 children with nocturnal enuresis) were selected from children referred to the Pediatric ward of Imam Reza Clinic in Shiraz, Iran...
February 5, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29573143/the-safety-and-efficacy-of-quadrivalent-live-attenuated-influenza-vaccine-in-japanese-children-aged-2-18-years-results-of-two-phase-3-studies
#15
Raburn M Mallory, Jing Yu, Sachiko Kameo, Michio Tanaka, Ki Rito, Yohji Itoh, Filip Dubovsky
BACKGROUND: Quadrivalent live attenuated influenza vaccine (Q/LAIV) has not been assessed in Japanese children. OBJECTIVES: Evaluate safety and efficacy of Q/LAIV in Japanese children. PATIENTS/METHODS: Two Phase 3 studies were conducted in the 2014-2015 influenza season. Study 1 was an open-label, uncontrolled single arm, multicenter study of Q/LAIV safety in subjects aged 2-6 years. Study 2 was a randomized, double-blind, placebo-controlled multicenter study of Q/LAIV safety and efficacy; subjects aged 7-18 years were randomized 2:1 to receive Q/LAIV or placebo...
March 23, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29560377/placebo-controlled-crossover-assessment-of-mecasermin-for-the-treatment-of-rett-syndrome
#16
Heather M O'Leary, Walter E Kaufmann, Katherine V Barnes, Kshitiz Rakesh, Kush Kapur, Daniel C Tarquinio, Nicole G Cantwell, Katherine J Roche, Suzanne A Rose, Alexandra C Walco, Natalie M Bruck, Grace A Bazin, Ingrid A Holm, Mark E Alexander, Lindsay C Swanson, Lauren M Baczewski, Juan M Mayor Torres, Charles A Nelson, Mustafa Sahin
Objective: To measure the efficacy of mecasermin (recombinant human insulin-like growth factor 1, rhIGF-1), for treating symptoms of Rett syndrome (RTT) in a pediatric population using a double-blind crossover study design. Methods: Thirty girls with classic RTT in postregression stage were randomly assigned to placebo or rhIGF-1 in treatment period 1 and crossed over to the opposite assignment for period 2 (both 20 weeks), separated by a 28-week washout period...
March 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29544738/a-randomized-double-blinded-placebo-controlled-study-of-the-use-of-viscous-oral-cromolyn-sodium-for-the-treatment-of-eosinophilic-esophagitis
#17
Jay Adam Lieberman, Jie Zhang, John Whitworth, Cary Cavender
BACKGROUND: There is a need for effective, nonsteroid pharmacologic therapies for eosinophilic esophagitis (EoE). Cromolyn sodium offers an option because mast cells have been implicated in the symptomatology of EoE and cromolyn has been shown to have some anti-eosinophilic properties. OBJECTIVE: To evaluate the efficacy of cromolyn in decreasing esophageal eosinophilia in patients with EoE. Secondary outcomes included symptom improvement and adverse effects. METHODS: We conducted a randomized, double-blinded, placebo-controlled trial of viscous oral cromolyn for EoE in pediatric patients...
May 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29538368/bifidobacterium-longum-subsp-infantis-cect7210-supplemented-formula-reduces-diarrhea-in-healthy-infants-a-randomized-controlled-trial
#18
Joaquin Escribano, Natalia Ferré, Mariona Gispert-Llaurado, Veronica Luque, Carmen Rubio-Torrents, Marta Zaragoza-Jordana, Isabel Polanco, Francisco M Codoñer, Empar Chenoll, Mireia Morera, Jose Antonio Moreno-Muñoz, Montserrat Rivero, Ricardo Closa-Monasterolo
BackgroundIntestinal microbiota of breast-fed infants is plenty of beneficial bifidobacteria. We aimed to determine whether an infant formula supplemented with probiotic Bifidobacterium longum subsp. infantis CECT7210 (B. infantis IM1) is effective at reducing diarrhea incidence in healthy term infants.MethodsDouble-blinded, randomized, multicenter, controlled clinical trial, where formula-fed infants (<3 months) received an infant formula supplemented (Probiotic) or not (Control) with 107  cfu/g of B...
May 2, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29538053/prevention-of-low-cardiac-output-syndrome-after-pediatric-cardiac-surgery-a-double-blind-randomized-clinical-pilot-study-comparing-dobutamine-and-milrinone
#19
Anna Cavigelli-Brunner, Maja I Hug, Hitendu Dave, Oskar Baenziger, Christoph Buerki, Dominique Bettex, Vincenzo Cannizzaro, Christian Balmer
OBJECTIVES: Dobutamine and milrinone are commonly used after open-heart surgery to prevent or treat low cardiac output syndrome. We sought to compare efficacy and safety of these drugs in pediatric patients. DESIGN: Prospective, single-center, double-blinded, randomized clinical pilot study. SETTING: Tertiary-care university children's hospital postoperative pediatric cardiac ICU. PATIENTS: After written consent, 50 consecutive patients (age, 0...
March 13, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29532087/the-changing-landscape-of-pediatric-migraine-therapy-a-review
#20
Carlyn Patterson-Gentile, Christina L Szperka
Importance: Migraine is a disabling and prevalent condition that affects the pediatric and adolescent population. This review describes current acute and preventive migraine pharmacologic therapies for the pediatric and adolescent population. Observations: Multiple pharmacotherapies that have been used in the treatment of acute headache and prevention in pediatric migraine are reviewed. There have been recent advances in the management of migraines among pediatric and adolescent patients, including US Food and Drug Administration approval of triptans for acute management in children as young as 6 years, and the first prospective, randomized, double-blind, placebo-controlled comparative study of preventive pharmacotherapy in pediatric migraine...
March 12, 2018: JAMA Neurology
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