Ali Farrokhi, Tanmaya Atre, Jenna Rever, Mario Fidanza, Wendy Duey, Samuel Salitra, Junia Myung, Meiyun Guo, Sumin Jo, Anuli Uzozie, Fatemeh Baharvand, Nina Rolf, Franziska Auer, Julia Hauer, Stephan A Grupp, Patrice Eydoux, Philipp F Lange, Alix E Seif, Christopher A Maxwell, Gregor S D Reid
The presence of supernumerary chromosomes is the only abnormality shared by all patients diagnosed with high-hyperdiploid B cell acute lymphoblastic leukemia (HD-ALL). Despite being the most frequently diagnosed pediatric leukemia, the lack of clonal molecular lesions and complete absence of appropriate experimental models have impeded the elucidation of HD-ALL leukemogenesis. Here, we report that for 23 leukemia samples isolated from moribund Eμ-Ret mice, all were characterized by non-random chromosomal gains, involving combinations of trisomy 9, 12, 14, 15, and 17...
March 22, 2024: Leukemia