keyword
MENU ▼
Read by QxMD icon Read
search

pediatric experimental study

keyword
https://www.readbyqxmd.com/read/27886579/a-cytokine-study-of-pediatric-tourette-s-disorder-without-obsessive-compulsive-disorder
#1
Seung-Min Yeon, Ju Hyung Lee, Daewon Kang, Hyuna Bae, Ki Yong Lee, Seohoon Jin, Jung Ryul Kim, Yong Woo Jung, Tae Won Park
It has been suggested that post-infectious inflammation in central nervous system is a cause of tic disorder including Tourette's disorder (TD). Since pro-inflammatory cytokines are important mediators inducing inflammation, the cytokine levels are regarded as one of the important indicators of inflammation. Several studies have investigated the relationship of autoimmunity and the pathogenesis of TD by measuring the inflammatory cytokine levels of blood. However, when using human samples, the experimental results can be affected by the factors like size of sample, comorbidity, medication that patients take and the severity of the diseases...
November 10, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27872050/experimental-systems-and-computational-approaches-to-understanding-the-microrna-mediated-reparative-potential-of-cardiac-progenitor-cell-derived-exosomes-from-pediatric-patients
#2
Udit Agarwal, Alex George, Srishti Bhutani, Shohini Ghosh-Choudhary, Josh T Maxwell, Milton E Brown, Yash Mehta, Manu O Platt, Yaxuan Liang, Susmita Sahoo, Michael E Davis
RATIONALE: Studies have demonstrated that exosomes can repair cardiac tissue post myocardial infarction (MI) and recapitulate the benefits of cellular therapy. OBJECTIVE: We evaluated the role of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes, in a rat model of ischemia reperfusion (IR) injury. METHODS AND RESULTS: Human CPCs from the right atrial appendages from children of different ages undergoing cardiac surgery for congenital heart defects were isolated and cultured under hypoxic or normoxic conditions...
November 21, 2016: Circulation Research
https://www.readbyqxmd.com/read/27859458/children-of-parents-with-bed-have-more-eating-behavior-disturbance-than-children-of-parents-with-obesity-or-healthy-weight
#3
Janet A Lydecker, Carlos M Grilo
OBJECTIVE: A limited literature suggests an association between parental eating disorders and child eating-disorder behaviors although this research has focused primarily on restrictive-type eating disorders and very little is known about families with binge-eating disorder (BED). METHODS: The current study focused on parents (N = 331; 103 fathers and 226 mothers), comparing parents with core features of BED (n = 63) to parents with obesity and no eating disorder (OB; n = 85) and parents with healthy-weight and no eating disorder (HW; n = 183)...
November 12, 2016: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/27845660/investigating-shear-wave-physics-in-a-generic-left-ventricular-model-via-in-vitro-experiments-and-finite-element-simulations
#4
Annette Caenen, Mathieu Pernot, Darya Shcherbakova, Luc Mertens, Mathias Kersemans, Patrick Segers, Abigail Swillens
Shear wave elastography (SWE) is a potentially valuable tool to non-invasively assess ventricular function in children with cardiac disorders, which could help in the early detection of abnormalities in muscle characteristics. Initial experiments demonstrated the potential of this technique in measuring ventricular stiffness, however, its performance remains to be validated as complicated shear wave (SW) propagation characteristics are expected to arise due to the complex non-homogeneous structure of the myocardium...
November 9, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27833115/transcriptome-assists-prognosis-of-disease-severity-in-respiratory-syncytial-virus-infected-infants
#5
Victor L Jong, Inge M L Ahout, Henk-Jan van den Ham, Jop Jans, Fatiha Zaaraoui-Boutahar, Aldert Zomer, Elles Simonetti, Maarten A Bijl, H Kim Brand, Wilfred F J van IJcken, Marien I de Jonge, Pieter L Fraaij, Ronald de Groot, Albert D M E Osterhaus, Marinus J Eijkemans, Gerben Ferwerda, Arno C Andeweg
Respiratory syncytial virus (RSV) causes infections that range from common cold to severe lower respiratory tract infection requiring high-level medical care. Prediction of the course of disease in individual patients remains challenging at the first visit to the pediatric wards and RSV infections may rapidly progress to severe disease. In this study we investigate whether there exists a genomic signature that can accurately predict the course of RSV. We used early blood microarray transcriptome profiles from 39 hospitalized infants that were followed until recovery and of which the level of disease severity was determined retrospectively...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27821622/interventions-for-reducing-parenting-stress-in-families-with-pediatric-conditions-an-integrative-review
#6
Nadya Golfenshtein, Einav Srulovici, Janet A Deatrick
Parenting stress increases in the presence of serious-acute or chronic pediatric health conditions, potentially triggering negative outcomes for families. Parenting stress reduction interventions have been widely disseminated. The current review describes the types, components, and outcomes of these interventions in diverse pediatric populations. A systematic literature search yielded 26 experimental and quasi-experimental studies describing such interventions. Quality assessment was conducted by two doctorally prepared nursing researchers using the Downs and Black's checklist for randomized and nonrandomized studies of health care interventions...
November 2016: Journal of Family Nursing
https://www.readbyqxmd.com/read/27810632/satisfaction-and-self-confidence-with-nursing-clinical-simulation-novice-learners-medium-fidelity-and-community-settings
#7
Jaclynn Lubbers, Carol Rossman
BACKGROUND: Simulation is fast becoming a normative pedagogy for a portion of clinical time in undergraduate nursing programs in the U.S. Studies have shown positive outcomes in increasing self-confidence and satisfaction with simulation. The questions remain as to which fidelity of simulation best matches which learners, how early can simulation begin with novice students, and in which contexts can simulation be best used for these early learners. This study was undertaken to find out if novice students were able to demonstrate increased satisfaction and self-confidence with medium fidelity simulation in community based roles, as these students have no knowledge of acute care skills at this point in their learning...
January 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27799905/cerebellar-and-spinal-direct-current-stimulation-in-children-computational-modeling-of-the-induced-electric-field
#8
Serena Fiocchi, Paolo Ravazzani, Alberto Priori, Marta Parazzini
Recent studies have shown that the specific application of transcranial direct current stimulation (tDCS) over the cerebellum can modulate cerebellar activity. In parallel, transcutaneous spinal DC stimulation (tsDCS) was found to be able to modulate conduction along the spinal cord and spinal cord functions. Of particular interest is the possible use of these techniques in pediatric age, since many pathologies and injuries, which affect the cerebellar cortex as well as spinal cord circuits, are diffuse in adults as well as in children...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27799065/a-case-study-of-an-integrative-genomic-and-experimental-therapeutic-approach-for-rare-tumors-identification-of-vulnerabilities-in-a-pediatric-poorly-differentiated-carcinoma
#9
Filemon S Dela Cruz, Daniel Diolaiti, Andrew T Turk, Allison R Rainey, Alberto Ambesi-Impiombato, Stuart J Andrews, Mahesh M Mansukhani, Peter L Nagy, Mariano J Alvarez, Andrea Califano, Farhad Forouhar, Beata Modzelewski, Chelsey M Mitchell, Darrell J Yamashiro, Lianna J Marks, Julia L Glade Bender, Andrew L Kung
BACKGROUND: Precision medicine approaches are ideally suited for rare tumors where comprehensive characterization may have diagnostic, prognostic, and therapeutic value. We describe the clinical case and molecular characterization of an adolescent with metastatic poorly differentiated carcinoma (PDC). Given the rarity and poor prognosis associated with PDC in children, we utilized genomic analysis and preclinical models to validate oncogenic drivers and identify molecular vulnerabilities...
October 31, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27763955/effectiveness-of-a-high-fidelity-simulation-based-training-program-in-managing-cardiac-arrhythmias-in-children-a-randomized-pilot-study
#10
Isabelle Bragard, Nesrine Farhat, Marie-Christine Seghaye, Oliver Karam, Arthur Neuschwander, Yasaman Shayan, Katharina Schumacher
OBJECTIVES: Pediatric cardiac arrest is a rare event. Its management requires technical (TSs) and nontechnical skills (NTSs). We assessed the effectiveness of a simulation-based training to improve these skills in managing life-threatening pediatric cardiac arrhythmias. METHODS: Four teams, each composed of 1 pediatric resident, 1 emergency medicine resident, and 2 pediatric nurses, were randomly assigned to the experimental group (EG) participating in 5 video-recorded simulation sessions with debriefing or to the control group (CG) assessed 2 times with video-recorded simulation sessions without debriefing at a 2-week interval...
October 18, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27749663/clinical-and-epidemiologic-features-of-visceral-leishmaniasis-in-children-in-southwestern-china-a-retrospective-analysis-from-2001-to-2015
#11
Ruixue Miao, Zhiling Wang, Qin Guo, Yang Wen, Qiong Liao, Yu Zhu, Min Shu, Chaomin Wan
BACKGROUND: Visceral Leishmaniasis (VL) is a life-threatening parasitic infection transmitted by phlebotomine sandflies. We undertook this study to analyze the clinical features of pediatric VL in a population of Chinese children. METHODS: A retrospective study was performed with pediatric patients (≤14years) diagnosed with VL based on bone-marrow biopsy, serology and diagnosis based on clinical manifestation and the improvement after the experimental drug when negative bone marrow and serology results were shown...
September 30, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27749435/implementation-of-a-sustainable-ventilator-associated-pneumonia-prevention-protocol-in-a-pediatric-intensive-care-unit-in-managua-nicaragua
#12
Kelsey Chinnadurai, Lindy Fenlason, Brian Bridges, Mana Espahbodi, Sivakumar Chinnadurai, Jane Blood-Siegfried
BACKGROUND: Ventilator-associated pneumonia (VAP) is a common nosocomial infection in pediatric intensive care units (ICUs). Ventilator-associated pneumonia protocols decrease the incidence of VAP; however, many components of these protocols are not feasible in all settings. This study was done in a large pediatric hospital in Nicaragua. OBJECTIVE: The aim of this study is to implement a sustainable evidence-based VAP protocol, in a different culture, for the purpose of decreasing VAP rates...
November 2016: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/27748332/implementation-of-a-pediatric-emergency-triage-system-in-xiamen-china
#13
Gang-Xi Lin, Yin-Ling Yang, Denise Kudirka, Colleen Church, Collin K K Yong, Fiona Reilly, Qi-Yi Zeng
BACKGROUND: Pediatric emergency rooms (PERs) in Chinese hospitals are perpetually full of sick and injured children because of the lack of sufficiently developed community hospitals and low access to family physicians. The aim of this study was to evaluate the clinical value of a new five-level Chinese pediatric emergency triage system (CPETS), modeled after the Canadian Triage System and Acuity Scale. METHODS: In this study, we compared CPETS outcomes in our PER relative to those of the prior two-level system...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27726071/the-relation-between-low-level-lead-exposure-and-oxidative-stress-a-review-of-the-epidemiological-evidence-in-children-and-non-occupationally-exposed-adults
#14
REVIEW
Aditi Roy, Katarzyna Kordas
Experimental studies in animals and observational studies in occupationally exposed adults indicate that higher lead exposure results in higher biomarkers of oxidative stress. However, this evidence cannot be extended to the general population who typically experience lower levels of lead exposure. This systematic review evaluates the epidemiological evidence on the association between lead and oxidative stress in non-occupationally exposed general population, with a particular focus on the pediatric population...
December 2016: Current Environmental Health Reports
https://www.readbyqxmd.com/read/27714658/a-systematic-review-on-the-adverse-health-effects-of-di-2-ethylhexyl-phthalate
#15
Maryam Zarean, Mojtaba Keikha, Parinaz Poursafa, Pooyan Khalighinejad, Mohammadmehdi Amin, Roya Kelishadi
Di (ethylhexyl) phthalate (DEHP) is a global environmental pollutant. This study aims to systematically review the literature on health effects of exposure to DEHP including effects on reproductive health, carcinogenesis, pregnancy outcome, and respiratory system. The literature search was done through Scopus, ISI Web of Science, Google Scholar, PubMed, Medline, and the reference lists of previous review articles to identify relevant articles published to June 2016 in each subject area. The inclusion criteria were as follows: original research, cross-sectional studies, case-control studies, cohort studies, interventional studies, and review articles...
October 6, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27713868/the-effect-of-the-family-empowerment-model-on-quality-of-life-in-children-with-chronic-renal-failure-children-s-and-parents-views
#16
Marzieh Sadat Minooei, Zohreh Ghazavi, Zahra Abdeyazdan, Alaleh Gheissari, Zeinab Hemati
BACKGROUND: Chronic renal failure (CRF) causes a gradual decline in kidney function to the extent that CRF patients need long-term clinical care, which affects the patients' family function and quality of life (QoL). OBJECTIVES: The present study was conducted to study the effects of the family-centered empowerment model on QoL in children with CRF during 2012-2013. PATIENTS AND METHODS: In this quasi-experimental study, 68 children with CRF and their parents were randomly assigned to two groups, intervention and control, via a random numbers table...
July 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27665781/flow-cytometric-analyses-of-the-viability-surface-marker-expression-and-function-of-lymphocytes-from-children-following-cryopreservation
#17
Xi Chen, Hui Zhang, Wenjun Mou, Zhan Qi, Xiaoya Ren, Guoliang Wang, Hong Jiao, Xiaohui Kong, Jingang Gui
Flow cytometric analysis is important for the investigation and clinical preparation of lymphocytes from children. However, the strict requirement of cell freshness and inter‑assay variability limits the application of this methodology for pediatric investigations. Therefore, it is necessary to identify a reliable cryopreservative method capable of maintaining high cell viability and proper cell function in lymphocytes from children. In the present study, eight commonly‑used cell cyropreservative methods were used, and their effects on cell viability, surface marker expression and cell function were examined...
September 26, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27648058/peer-interaction-and-group-education-for-adaptation-to-disease-in-adolescents-with-type-1-diabetes-mellitus
#18
Sebahat Altundag, Meral Bayat
OBJECTIVE: To evaluate the effects of group interaction and training in the adaptation process to disease in adolescents with type 1 diabetes mellitus (T1DM). METHODS: This experimental study with pre- and post-test control groups was conducted in the pediatric endocrine clinic at a university hospital. The data were collected through descriptive data form, social support assessment scale, self-esteem inventory and information form. The data collection forms were administered four times with 3-month intervals to the study and control groups...
July 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27638717/pathogenesis-of-cerebral-palsy-through-the-prism-of-immune-regulation-of-nervous-tissue-homeostasis-literature-review
#19
Natalya Lisovska, Zholtay Daribayev, Yevgeny Lisovskyy, Kenzhe Kussainova, Lana Austin, Sholpan Bulekbayeva
BACKGROUND: The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability. Though the great progress in the neuroscience has been recently achieved, the pathogenesis of cerebral palsy is still poorly understood. METHODS: In this work, we reviewed available experimental and clinical data concerning the role of immune cells in pathogenesis of cerebral palsy. Maintaining of homeostasis in nervous tissue and its transformation in case of periventricular leukomalacia were analyzed...
September 14, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27626486/toxicological-and-efficacy-assessment-of-post-transition-metal-indium-phthalocyanine-for-photodynamic-therapy-in-neuroblastoma
#20
Monica Neagu, Carolina Constantin, Mircea Tampa, Clara Matei, Andreea Lupu, Emilia Manole, Rodica-Mariana Ion, Concettina Fenga, Aristidis M Tsatsakis
Metallo-phthalocyanines due to their photophysical characteristics as high yield of triplet state and long lifetimes, appear to be good candidates for photodynamic therapy (PDT). Complexes with diamagnetic metals such as Zn2+, Al3+ Ga3+ and In3+meet such requirements and are recognized as potential PDT agents. Clinically, Photofrin® PDT in neuroblastoma therapy proved in pediatric subjects diagnosed with progressive/recurrent malignant brain tumors increased progression free survival and overall survival outcome...
September 10, 2016: Oncotarget
keyword
keyword
75873
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"